T2D_r2_10_4054_4668_+ FIG00000223 119 21 120 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_r2_31_5023_5937_- FIG00001189 156 28 157 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_52_8820_9047_+ FIG00002716 12 2 13 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_r2_96_1148_1291_+ FIG00001932 37 5 37 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_130_5374_5568_+ FIG00011382 4 2 5 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_r2_143_9121_9447_+ FIG00030688 11 3 12 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_r2_173_936_1079_+ FIG00001385 12 2 13 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_186_10094_10408_- FIG00132994 3 2 4 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_191_12657_12989_+ FIG00001088 86 12 86 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_217_14110_14634_+ FIG00059211 57 11 58 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_291_9054_9338_+ FIG00340292 4 3 5 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_311_1_391_+ FIG00000441 110 15 110 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_403_814_1041_+ FIG00075970 4 2 6 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_420_6107_6781_+ FIG00064110 13 7 17 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_429_10925_11077_- FIG00003460 14 3 15 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_463_894_1967_- FIG00001522 52 13 54 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_r2_463_1973_2359_- FIG00001522 19 4 21 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_r2_463_2813_3088_- FIG00149566 19 4 20 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_463_3227_4033_- FIG01176807 15 6 17 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_467_5943_6188_- FIG00002049 12 3 14 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_488_3978_4253_- FIG00000314 6 2 8 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_r2_490_869_1036_+ FIG00004078 28 5 29 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_549_4537_5040_+ FIG00051161 17 5 20 3'-phosphoadenosine 5'-phosphosulfate sulfurtransferase DndC DNA phosphorothioation 1 T2D_r2_578_1531_1722_- FIG00001548 50 7 50 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_604_526_906_- FIG00000101 51 9 52 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_r2_635_9344_9704_+ FIG00001189 81 12 82 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_636_4958_5125_- FIG00001088 30 5 30 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_716_5466_5948_- FIG00501923 13 4 15 N-Acetyl-D-glucosamine ABC transport system, permease protein 2 Chitin and N-acetylglucosamine utilization 2 T2D_r2_784_8758_8919_- FIG00139262 34 5 34 Poly(glycerol-phosphate) alpha-glucosyltransferase (EC 2.4.1.52) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_808_7795_8016_+ FIG00000482 21 4 22 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_824_8293_8604_+ FIG00019251 13 5 14 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_973_6519_7019_+ FIG00005547 20 8 21 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_r2_1003_158_931_- FIG00000395 20 6 24 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_1003_994_1320_- FIG00000395 22 6 24 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_1003_4952_5233_- FIG00134342 28 5 29 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_r2_1030_3836_4117_- FIG00050603 15 3 16 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_1048_7581_7802_+ FIG00075702 27 4 29 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_1107_1958_2902_- FIG00132617 121 24 124 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_1138_506_652_- FIG00002344 10 3 11 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r2_1172_946_1371_- FIG00007339 8 3 10 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_r2_1288_6830_7024_+ FIG00138468 15 4 16 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_1306_1_670_+ FIG00002718 41 10 43 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_1306_4999_5466_+ FIG00077620 3 2 4 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_1364_5777_6052_+ FIG00000103 16 3 18 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_1562_5969_6514_- FIG00000185 89 16 91 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_1641_4969_5199_- FIG00543846 3 2 6 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_r2_1727_1_983_- FIG00067248 128 28 132 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_1727_1346_2119_+ FIG00007079 31 8 32 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_1747_5955_6184_- FIG00002344 18 5 19 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r2_1791_2499_3032_+ FIG01956038 8 4 11 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_r2_1807_952_1800_- FIG00001189 104 22 106 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_1807_3864_4043_+ FIG00004843 7 2 8 Protein YidD Cell Division Subsystem including YidCD 1 T2D_r2_1831_5599_5961_- FIG00008490 18 8 50 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_1874_5779_5988_- FIG00000166 9 2 10 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_r2_1877_4958_5146_- FIG00136522 25 5 27 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_r2_1914_3064_3672_+ FIG00000380 11 4 13 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_1927_3083_3295_+ FIG00093352 4 2 5 CRISPR-associated RecB family exonuclease Cas4a CRISPRs 1 T2D_r2_1956_5352_5486_+ FIG00000471 13 4 13 LSU ribosomal protein L34p Cell Division Subsystem including YidCD 1 T2D_r2_1962_3420_4229_+ FIG00006691 3 6 8 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_1962_4314_5006_+ FIG00002049 15 7 17 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_1962_5027_5386_+ FIG00002049 11 5 13 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_1962_5454_5840_+ FIG00018865 3 3 4 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_1999_1_498_- FIG00004021 30 7 31 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_r2_2021_2974_3843_- FIG00064110 159 27 160 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_2024_4904_5050_+ FIG00017190 5 2 6 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_2026_3926_4903_- FIG00006463 14 9 16 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_2067_1075_1428_+ FIG00000047 54 10 55 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_2243_2969_3106_- 26 4 27 Biotin synthesis protein BioC Biotin biosynthesis 1X T2D_r2_2281_4857_5072_+ FIG00134167 9 3 10 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_2282_4973_5393_- FIG01260980 102 16 103 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_2286_764_940_- FIG00000280 17 3 19 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_2345_1_957_- FIG00088067 55 10 63 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_r2_2349_1316_2140_+ FIG00085740 21 7 30 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_2434_1_208_- FIG00018865 14 3 16 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_2434_223_936_- FIG00002049 40 13 41 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_2434_1931_2137_- FIG00006691 5 2 6 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_2506_1078_2310_+ FIG00132801 20 6 24 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_r2_2506_2316_3158_+ FIG00000350 7 5 9 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_2587_1_792_- FIG00003788 20 6 24 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_2587_3977_4960_- FIG00002470 38 11 40 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_2617_1392_2018_+ FIG00007957 37 11 41 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_2640_1967_2407_- FIG00130344 37 8 39 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_2640_3986_4612_- FIG00000056 92 16 93 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_r2_2640_4659_4949_- FIG00009229 20 5 21 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_r2_2683_4008_4349_+ FIG00011537 10 4 11 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_2698_2287_2448_+ FIG00003460 9 4 11 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_2720_1818_2747_- FIG00007514 22 9 26 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_2782_3069_3413_+ FIG00137389 11 3 13 Hydroxypyruvate isomerase (EC 5.3.1.22) Glycerate metabolism 4 T2D_r2_2782_4410_4902_+ FIG00000370 6 3 7 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_2847_1094_1564_- FIG00000288 21 7 23 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_r2_2874_691_1029_+ FIG01228918 83 12 83 ErfK/YbiS/YcfS/YnhG family protein Copper homeostasis 12 T2D_r2_2897_1_374_- FIG00000822 40 7 41 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_r2_2944_2993_3859_- FIG00014000 29 8 33 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_r2_2982_3865_4242_- FIG00000070 43 8 44 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_3012_3779_4709_- FIG00000147 80 17 82 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_3014_3334_3858_- FIG01260980 60 13 62 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_3052_2899_3939_- FIG00001294 255 38 255 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_r2_3052_3972_4670_- FIG00001294 177 25 177 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_r2_3131_1031_1762_+ FIG00004021 28 11 32 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_r2_3175_1970_2938_- FIG01260980 225 34 226 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_3175_2962_3318_- FIG01260980 50 9 51 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_3209_1_621_- FIG00001902 60 15 63 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_3209_1101_1421_- FIG00005329 4 2 5 V-type ATP synthase subunit F (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_3209_3162_3650_- FIG00003998 74 14 75 V-type ATP synthase subunit K (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_3209_3961_4536_- FIG00140555 13 5 15 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_3243_1_349_- FIG00001871 76 13 76 Glycerol-3-phosphate ABC transporter, permease protein UgpE (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_3261_1950_2102_- FIG00000200 28 4 28 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_r2_3313_1041_1328_+ FIG00005698 11 6 15 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_r2_3313_4033_4466_+ FIG00008556 7 5 9 L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_3357_3758_4012_+ FIG00000333 15 4 17 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_3383_1007_1489_- FIG01280345 22 7 23 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_r2_3383_2975_3736_- FIG00034392 95 17 96 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_3430_2038_2421_+ FIG00038814 34 7 36 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_r2_3443_766_978_- FIG01260980 59 8 59 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_3486_3744_4052_+ FIG00008490 36 7 38 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_3529_1681_2916_- FIG01260980 68 18 72 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_3529_3914_4317_- FIG01260980 15 3 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_3538_4004_4311_+ FIG00000803 7 2 9 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_r2_3622_929_1195_- FIG01583289 44 7 46 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_r2_3637_3020_3637_+ FIG00000365 65 14 67 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_3761_642_1043_+ FIG00000165 71 12 72 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r2_3780_987_1142_- FIG00000130 6 2 8 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_3850_1972_2115_- FIG00001237 30 4 30 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_r2_3865_1332_2018_+ FIG00001088 177 26 178 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_3867_925_1803_- FIG00001548 24 7 27 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_3867_1920_2783_- FIG00001548 10 3 11 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_3938_2103_2273_+ FIG00000243 10 3 11 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_3995_3078_3512_+ FIG00000323 88 16 89 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_4072_1150_1500_- FIG00003845 20 7 21 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_r2_4151_520_1023_+ FIG00719736 19 6 22 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_4210_1_611_- FIG00031250 4 4 7 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_4212_2496_3920_+ FIG00000803 8 3 10 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_r2_4375_1_1022_+ FIG00051439 83 19 85 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_4375_1816_2475_- FIG00003460 5 3 7 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_4385_1092_1946_- FIG00002239 16 5 19 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_4452_1_294_+ FIG00000025 9 2 10 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_4452_2034_2171_+ FIG00000261 14 3 15 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_4483_2996_3493_- FIG00077620 58 11 60 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_4514_984_1469_- FIG00009044 138 19 138 Thiol-activated cytolysin Listeria Pathogenicity Island LIPI-1 extended 2 T2D_r2_4514_1477_1803_- FIG00009044 84 13 84 Thiol-activated cytolysin Listeria Pathogenicity Island LIPI-1 extended 2 T2D_r2_4526_1_748_+ FIG00000084 115 23 117 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_r2_4526_3445_3799_+ FIG00028461 14 4 15 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_4539_1204_2034_+ FIG00000011 8 7 10 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_4542_1_1095_+ FIG00000372 39 13 41 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_4555_1_1005_+ FIG00000404 120 25 122 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_4564_2985_3161_- FIG00000542 22 4 22 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_4616_3587_3751_+ FIG00059124 24 5 25 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_r2_4663_971_1123_- FIG00005283 3 2 4 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_r2_4710_3225_3700_+ FIG00000341 38 10 39 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_4724_2012_2260_+ FIG00026750 3 2 5 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_r2_4747_2399_3007_+ FIG00000235 20 6 22 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_4751_1227_1922_- FIG00012814 10 6 16 Spore cortex-lytic enzyme, N-acetylglucosaminidase SleL (EC 3.2.1.-) Spore germination 1 T2D_r2_4760_1980_2762_- FIG00000165 120 23 123 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r2_4776_947_1219_- FIG00026137 25 5 26 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_4786_2551_2727_- FIG00000053 10 3 10 LSU ribosomal protein L33p Ribosome LSU bacterial 9 T2D_r2_4889_1_637_- FIG00036320 176 25 176 Alpha-1,4-N-acetylgalactosamine transferase PglJ (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_4946_1061_2053_+ FIG00000504 10 5 12 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_4993_1_456_+ FIG01955818 9 3 11 Pyruvate:ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_r2_4993_2106_2516_+ FIG00719736 38 9 40 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_5014_786_926_- FIG00002818 32 5 32 Inner membrane protein translocase component YidC, long form Cell Division Subsystem including YidCD 1 T2D_r2_5014_962_1975_- FIG00002818 267 39 267 Inner membrane protein translocase component YidC, long form Cell Division Subsystem including YidCD 1 T2D_r2_5014_1978_2433_- FIG00002818 9 5 12 Inner membrane protein translocase component YidC, long form Cell Division Subsystem including YidCD 1 T2D_r2_5014_2461_2691_- FIG00004843 64 9 64 Protein YidD Cell Division Subsystem including YidCD 1 T2D_r2_5027_3026_3579_+ FIG00031969 151 22 151 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_r2_5040_1_280_+ FIG00001269 52 9 53 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_5045_1020_1493_+ FIG00000402 44 11 46 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_5045_1537_2076_+ FIG00000402 9 2 10 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_5115_1_242_- FIG00001269 40 7 41 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_5117_1_323_- FIG00000212 14 4 16 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_r2_5117_382_714_- FIG00075970 11 4 12 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_5157_2243_2902_- FIG00000721 9 6 11 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_5178_2494_2967_- FIG00104848 39 10 41 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_5240_1846_2073_+ FIG00001980 9 3 10 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_r2_5266_305_1006_+ FIG00007941 32 9 38 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_r2_5270_1953_2087_- FIG00000392 15 3 16 Transcription termination factor Rho Transcription factors bacterial 1 T2D_r2_5276_1119_1583_- FIG00002944 5 3 6 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_r2_5304_557_1135_+ FIG00129616 42 10 43 GTP-binding protein EngA Universal GTPases 2 T2D_r2_5304_1162_1881_+ FIG00129616 65 16 67 GTP-binding protein EngA Universal GTPases 2 T2D_r2_5304_3015_3473_+ FIG00000309 59 12 61 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_r2_5441_1819_2052_+ FIG00028461 13 5 14 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_5462_2403_3059_+ FIG00000395 83 17 84 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_5462_3074_3413_+ FIG00000395 40 8 41 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_5465_3211_3408_+ FIG00130344 41 6 42 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_5485_251_991_- FIG00002968 22 7 25 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_r2_5548_2358_2849_- FIG00007957 61 12 63 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_5607_1_669_- FIG00004014 57 13 59 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_r2_5607_2097_3357_+ FIG00000210 4 6 8 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_r2_5621_258_1082_+ FIG00000578 42 11 44 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_5638_1283_1861_- FIG00139150 23 6 25 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit B p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_5638_1876_2724_- FIG00139150 35 12 36 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit B p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_5646_593_970_- FIG00007495 16 5 18 Spore maturation protein B Spore Core Dehydration 1.1 T2D_r2_5646_1110_1688_- FIG00003439 11 5 14 Spore maturation protein A Spore Core Dehydration 1.1 T2D_r2_5707_3010_3324_+ FIG00000441 36 8 38 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_5734_1803_2867_- FIG00000404 71 19 72 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_5811_2919_3291_- FIG01304818 16 4 18 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_r2_5816_2026_2235_+ FIG00543846 45 7 45 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_r2_5844_1_886_+ FIG00052605 22 8 26 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_5848_330_1013_+ FIG00141373 152 24 153 Regulatory protein SusR Cellulosome 1.x T2D_r2_5861_1_602_+ FIG00000043 14 5 17 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_5861_925_1812_- FIG00007147 21 8 23 Glycosyltransferase LafB, responsible for the formation of Gal-Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_r2_5865_1_1041_+ FIG00000116 67 19 69 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_5919_553_1104_+ FIG00000208 53 9 54 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_r2_6004_2170_2967_- FIG00059211 26 11 29 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_6013_2600_3001_+ FIG00122441 108 15 108 Two-component sensor kinase SA14-24 Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_6016_683_1012_+ FIG00000089 74 12 74 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_r2_6017_2895_3044_+ FIG00067562 13 3 13 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_6030_2822_3230_- FIG00000395 6 2 8 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_6049_1580_1864_- FIG00000377 7 2 8 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_6049_1990_2457_- FIG00000377 14 5 16 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_6082_2989_3216_- FIG00001469 7 3 9 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_6116_587_2158_+ FIG00000001 19 7 37 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_6131_1996_2214_+ FIG00007658 10 4 11 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_r2_6136_1171_1422_+ FIG00002020 18 6 19 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_6247_1_198_- FIG00000226 46 8 46 GTP cyclohydrolase I (EC 3.5.4.16) type 1 Zinc regulated enzymes 1 T2D_r2_6250_1_772_- FIG01303880 126 25 127 Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex (EC 1.8.1.4) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_6269_1_461_- FIG00008736 12 3 14 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_6299_1976_2980_- FIG00001269 82 20 85 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_6387_917_1126_+ FIG01955774 16 3 17 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_r2_6418_2957_3129_- FIG01260980 30 5 31 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_6431_2862_3126_- FIG00016888 33 5 35 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_r2_6444_1123_1554_- FIG00010844 33 6 35 Flavodoxin Flavodoxin 1 T2D_r2_6456_1_611_- FIG00000555 17 5 21 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_6456_925_1458_- FIG00000208 23 8 25 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_r2_6456_1985_2854_- FIG00000446 43 12 45 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_6474_686_1099_+ FIG00009628 24 8 26 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_r2_6513_2886_3104_+ FIG00002300 8 2 10 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_r2_6591_174_1100_+ FIG00000188 44 13 50 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_r2_6658_1982_2530_- FIG00010134 44 9 47 Methionine transporter MetT Methionine Degradation 3 T2D_r2_6697_1943_2767_- FIG00000372 114 23 116 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_6712_2670_2966_- FIG00000241 57 10 57 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_6744_1526_1939_- FIG00001106 70 12 71 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_r2_6744_1996_2388_- FIG00001106 72 11 73 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_r2_6744_2627_2842_- FIG00051439 25 6 26 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_6766_2327_3010_+ FIG00031250 20 7 22 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_6791_1_724_+ FIG00001834 34 11 37 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_6791_1984_2946_+ FIG00004453 21 7 24 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_r2_6834_2298_2732_+ FIG00095112 24 8 25 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) DNA-replication 4 T2D_r2_6834_2800_3003_+ FIG00000314 7 2 9 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_r2_6912_1_275_- FIG00000782 19 4 20 Exonuclease SbcD DNA repair, bacterial 3 T2D_r2_6991_2480_2992_- FIG00018865 33 8 34 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_7052_2026_2975_+ FIG00001902 79 18 81 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_7122_977_1354_- FIG00007957 20 5 23 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_7153_732_1025_+ FIG00000001 20 4 21 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_7176_1650_1892_- FIG00013626 66 9 66 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_r2_7218_149_1069_+ FIG00038343 11 5 13 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_r2_7265_1_564_+ FIG00132617 38 10 40 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_7265_1322_2104_+ FIG00001819 104 21 105 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_r2_7265_2134_2655_+ FIG00000202 45 13 47 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_7294_2404_2640_- FIG00015476 12 2 13 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_r2_7434_2125_2628_+ FIG00000476 58 11 59 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_7455_1977_2288_- FIG00010844 7 4 8 Flavodoxin Flavodoxin 1 T2D_r2_7499_2348_2548_+ FIG00000621 11 4 12 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_7571_1971_2870_- FIG00000001 67 18 70 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_7592_649_1194_+ FIG00000365 52 9 54 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_7626_1_1014_+ FIG00028461 90 21 91 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_7669_1_405_- FIG00000081 22 5 23 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_7670_468_1049_+ FIG00001750 85 15 85 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_7685_2081_2425_- FIG00000557 16 5 17 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_r2_7686_2290_2826_+ FIG00000015 15 6 17 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_7730_84_1004_+ FIG00000279 54 15 59 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_7768_2665_2829_- FIG00019497 7 2 8 Beta-ureidopropionase (EC 3.5.1.6) Hydantoin metabolism 4 T2D_r2_7776_2661_2827_- FIG00018369 22 5 23 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_7784_1_210_+ FIG00002041 9 3 10 Flagellar motor switch protein FliN Bacterial Chemotaxis 9 T2D_r2_7830_327_1022_+ FIG00080955 6 3 8 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_7862_1996_2379_+ FIG00000252 8 4 10 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_r2_7862_2549_2810_+ FIG00000040 17 4 18 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r2_7967_1_654_+ FIG00049433 14 6 18 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_7969_1116_2114_+ FIG00005216 142 27 143 Sulfate permease Cysteine Biosynthesis 2.17 T2D_r2_7991_451_957_- FIG00088533 43 9 46 Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Cobalamin synthesis 2 T2D_r2_7995_139_1011_+ FIG00000420 13 7 16 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_7995_2400_2784_+ FIG00000442 46 12 47 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_7998_978_1835_- FIG00001548 241 34 242 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_8028_304_582_+ FIG00000394 36 7 38 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_8028_753_1088_+ FIG01266244 30 7 31 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_8105_2090_2494_+ FIG00001408 3 2 5 Rrf2 family transcriptional regulator Rrf2 family transcriptional regulators 4 T2D_r2_8136_2187_2759_- FIG00001166 6 5 14 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_8298_1430_2200_+ FIG00006092 9 3 11 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_8307_1967_2728_- FIG00000317 42 8 44 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_8375_87_917_- FIG00000659 179 31 180 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_8375_1058_2017_+ FIG00000420 240 36 241 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_8443_2109_2252_+ FIG00136866 11 3 12 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_r2_8538_1537_2079_+ FIG00004453 128 18 128 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_r2_8581_349_1137_+ FIG00000770 21 7 27 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_r2_8653_2049_2668_+ FIG00046929 76 16 77 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_8704_1917_2267_- FIG00001548 11 5 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_8712_1_167_- FIG00001550 10 2 11 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_r2_8715_776_955_- FIG00001834 43 6 43 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_8764_1845_2609_- FIG00137389 7 4 9 Hydroxypyruvate isomerase (EC 5.3.1.22) Glycerate metabolism 4 T2D_r2_8772_1_197_- FIG00001550 23 6 24 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_r2_8893_1_392_- FIG00013994 13 5 15 Short chain fatty acids transporter Polyhydroxybutyrate metabolism 5.6 T2D_r2_8906_2393_2630_+ FIG00033206 15 3 16 Enoyl-CoA hydratase (EC 4.2.1.17) Polyhydroxybutyrate metabolism 5.6 T2D_r2_8911_1_1024_+ FIG00009149 136 29 141 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_8911_1027_1221_+ FIG00009149 9 3 13 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_8924_1_197_- FIG00009564 15 4 16 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_r2_8994_1975_2616_- FIG00003844 7 4 9 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_r2_9201_1973_2161_- FIG00013638 16 4 18 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_9293_1129_1329_+ FIG01260980 48 7 48 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_9314_35_337_- FIG00009156 34 7 35 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_r2_9344_2130_2559_+ FIG00000414 75 14 76 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_r2_9345_1983_2559_- FIG00000793 56 14 58 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_9362_1815_2048_+ FIG00002020 51 7 51 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_9374_1_629_- FIG00000822 27 8 29 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_r2_9383_1_410_- FIG00129130 36 8 38 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_r2_9432_1496_1924_- FIG00008490 51 10 53 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_9436_2285_2548_- FIG00003715 3 3 6 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_9469_1975_2543_- FIG00000038 29 9 30 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_9471_1_937_- FIG00018699 4 5 7 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_9550_1_420_- FIG00000177 44 8 45 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_r2_9662_201_953_- FIG00945384 166 28 166 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_9664_1324_1935_- FIG00000358 40 9 42 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_r2_9673_2130_2512_+ FIG00000111 51 11 52 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_9690_1_231_- FIG00001798 50 9 50 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_r2_9703_376_546_+ FIG00001676 16 5 17 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_9731_2155_2505_- FIG00003175 66 10 68 Pyruvate:ferredoxin oxidoreductase, beta subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_r2_9743_102_260_- FIG01955902 19 4 19 Rubredoxin Rubrerythrin 2 T2D_r2_9769_111_674_- FIG00001636 133 21 133 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_r2_9796_479_940_- FIG00001020 5 3 6 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_9869_1898_2484_- FIG00000793 17 6 19 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_9954_1857_2141_- FIG00000477 28 5 29 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_9984_658_1038_+ FIG00000584 7 5 9 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_10050_1853_2035_+ FIG00000420 11 3 13 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_10057_1176_2042_+ FIG00000539 68 15 72 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_10071_969_1637_- FIG00000235 59 16 60 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_10079_928_1287_- FIG00054694 8 3 9 Predicted rhamnose oligosaccharide ABC transport system, substrate-binding component L-rhamnose utilization 1 T2D_r2_10085_1973_2457_- FIG00018561 42 11 44 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_10086_1514_1993_- FIG00000113 21 5 23 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_10090_1830_2024_+ FIG01260980 38 6 39 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_10096_1123_1302_+ FIG00049433 6 2 6 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_10105_1977_2455_- FIG00117785 16 5 18 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_r2_10108_599_1036_+ FIG00000449 68 12 70 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_r2_10150_1937_2448_- FIG00016566 37 8 39 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_r2_10236_1806_2042_+ FIG00000494 8 4 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_10251_652_1092_+ FIG00013525 16 3 18 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_r2_10251_2100_2432_+ FIG00016836 19 4 20 Transcription termination protein NusB Transcription factors bacterial 1 T2D_r2_10280_992_2140_+ FIG00129130 201 32 202 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_r2_10292_1_777_- FIG00018457 10 7 12 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_10293_1974_2427_- FIG00001865 26 7 28 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_r2_10294_1167_1901_- FIG00719736 19 9 21 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_10304_2238_2426_- FIG00000452 6 2 8 Chemotaxis protein methyltransferase CheR (EC 2.1.1.80) Bacterial Chemotaxis 9 T2D_r2_10323_445_1002_+ FIG00047509 130 21 130 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_10323_1056_1319_+ FIG00047509 64 10 64 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_10323_1347_2315_+ FIG00006151 99 20 101 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_10435_1140_1631_- FIG00000328 22 10 24 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_r2_10552_994_1602_- FIG00000207 48 11 50 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_10634_2174_2385_- FIG01260980 45 7 45 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_10700_2046_2376_+ FIG00031250 7 3 8 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_10723_1989_2374_- FIG00001347 31 7 32 Chitinase (EC 3.2.1.14) Chitin and N-acetylglucosamine utilization 2 T2D_r2_10777_1908_2367_- FIG00000395 18 4 19 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_10788_1417_1989_- FIG00000825 65 13 68 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_10854_1558_2010_+ FIG00005893 22 7 23 ATPase component STY3233 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_r2_10879_1247_1912_- FIG00130344 78 14 80 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_10982_1_1020_+ FIG00001269 69 17 71 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_11094_1_347_- FIG00016663 15 4 17 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_11100_1977_2330_- FIG00561498 6 2 8 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_11121_1974_2327_- FIG00008736 26 7 27 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_11133_1158_2000_+ FIG00453259 3 4 5 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_r2_11278_734_1879_- FIG01176807 76 16 81 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_11336_1972_2303_- FIG00049154 21 4 22 Spore maturation protein A-like protein Spore Core Dehydration 1.1 T2D_r2_11339_2172_2303_- FIG00000102 32 5 32 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_11360_1_758_- FIG00340292 53 11 55 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_11360_773_943_- FIG00010442 10 3 11 Transmembrane component BL0694 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_11360_952_1437_- FIG00010442 17 4 18 Transmembrane component BL0694 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_11361_705_1004_+ FIG00006463 6 2 7 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_11377_1966_2298_- FIG00000341 25 6 26 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_11385_1_1156_- FIG00001044 160 30 163 Respiratory nitrate reductase alpha chain (EC 1.7.99.4) Nitrate and nitrite ammonification 1 T2D_r2_11403_1_713_+ FIG00010478 8 3 11 Phosphonate ABC transporter permease protein phnE2 (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_r2_11437_565_927_- FIG00006463 7 4 8 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_11437_966_1853_- FIG00006463 27 10 28 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_11469_1959_2286_- FIG00000147 50 8 51 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_11470_1_1878_+ FIG00000147 49 23 140 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_11651_1_360_- FIG00719736 9 4 11 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_11654_1226_1957_- FIG00000176 86 17 87 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_11772_1990_2251_- FIG00093180 60 10 61 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_11779_716_1099_- FIG00001719 33 8 37 Co-activator of prophage gene expression IbrB IbrA and IbrB: co-activators of prophage gene expression 1 T2D_r2_11783_1173_1559_+ FIG00000185 29 7 31 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_11839_1_479_- FIG00000260 57 10 59 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_11850_351_632_- FIG00015476 20 4 21 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_r2_11871_1063_1443_+ FIG00017454 83 14 83 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_11871_1457_2029_+ FIG00042781 142 21 142 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_11916_1283_1570_+ FIG00000025 51 10 51 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_11919_1_817_+ FIG00000552 11 7 16 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_r2_11934_2037_2236_+ FIG00000673 20 5 22 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_r2_12002_1887_2228_- FIG00000681 54 8 55 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_r2_12003_1416_2096_+ FIG00143531 154 23 155 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_r2_12119_125_856_+ FIG00008490 93 16 94 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_12144_2078_2213_+ FIG00011114 29 4 29 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_12150_1654_2133_+ FIG00001656 74 13 76 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_r2_12170_1_934_- FIG00021289 92 21 94 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_12182_1_733_- FIG00001583 8 5 10 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_r2_12186_1_704_+ FIG00000175 6 4 9 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_r2_12189_1916_2210_- FIG01260980 55 8 55 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_12192_1_402_+ FIG00018699 113 16 113 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_12194_598_1095_+ FIG00016514 53 11 54 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_12231_947_1351_- FIG00122145 14 5 16 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_12302_1467_2039_+ FIG00007957 28 7 30 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_12310_932_1366_+ FIG00009628 32 5 33 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_r2_12339_1_882_+ FIG00010508 38 11 40 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_12359_1058_1660_+ FIG00000148 81 15 82 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_r2_12383_1_1002_+ FIG00001168 56 18 59 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_12383_1299_2190_+ FIG00002470 29 7 33 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_12388_1_419_- FIG00001719 14 5 16 Co-activator of prophage gene expression IbrB IbrA and IbrB: co-activators of prophage gene expression 1 T2D_r2_12388_944_2029_- FIG00001798 47 14 49 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_r2_12405_105_1031_+ FIG00007079 17 5 20 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_12408_1972_2187_- FIG00001647 52 7 52 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_r2_12413_1007_1528_+ FIG00001818 76 14 78 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_r2_12414_951_1187_- FIG00005893 5 2 7 ATPase component STY3233 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_r2_12442_493_1146_+ FIG00554193 10 4 12 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_12479_1569_1961_- FIG00025086 24 6 25 Xanthine permease Purine Utilization 1 T2D_r2_12484_1_272_+ FIG00000025 16 4 18 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_12484_1047_1541_+ FIG00047056 20 5 22 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_r2_12484_1606_2115_+ FIG00034392 20 6 22 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_12505_1_509_+ FIG00000241 18 6 20 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_12505_580_1053_+ FIG00132617 3 3 4 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_12520_592_1017_+ FIG00012945 4 5 6 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_12567_1964_2146_- FIG00000532 23 5 23 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_12582_1_306_+ FIG00003472 24 6 26 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_12585_315_923_- FIG00001518 10 4 12 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_r2_12624_1868_2137_- FIG00000263 19 4 20 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_12630_244_441_- FIG00001133 6 2 7 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_r2_12679_1958_2158_- FIG00000147 35 6 36 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_12701_988_1668_- FIG01260980 123 20 123 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_12767_1_586_+ FIG00000065 94 15 95 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_12767_830_1648_- FIG00008507 16 7 19 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_r2_12795_1_211_- FIG00023946 26 4 27 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_12849_806_1111_+ FIG00001642 10 2 11 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_12849_1923_2142_- FIG00001076 7 3 9 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_12862_1976_2141_- FIG00000268 14 2 14 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_12889_1810_2034_+ FIG00000377 19 5 20 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_12932_240_935_- FIG00133744 9 6 15 Nitric oxide reductase activation protein NorQ Flavohaemoglobin 1 T2D_r2_12976_490_798_- FIG00000184 16 3 17 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_12985_646_939_- FIG00002470 74 11 74 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_12998_1_569_- FIG00000343 59 12 60 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_13094_1516_1992_- FIG00000464 15 9 18 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_13121_1988_2117_- FIG00719736 18 4 19 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_13145_1_276_- FIG00016265 45 8 45 Carboxynorspermidine dehydrogenase, putative (EC 1.1.1.-) Polyamine Metabolism 2 T2D_r2_13170_1747_1980_- FIG00002395 5 2 7 Cysteinyl-tRNA synthetase related protein CBSS-261594.1.peg.788 1 T2D_r2_13197_401_1081_+ FIG00004568 16 6 19 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Alkanesulfonate assimilation 9.? T2D_r2_13205_1_977_- FIG00010771 255 39 255 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_13280_949_1125_- FIG00000897 16 3 17 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_r2_13331_997_1257_+ FIG01318274 51 9 51 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_13416_988_1758_- FIG00000001 46 13 49 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_13454_949_1257_- FIG00007960 73 10 74 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_13519_1_346_+ FIG00000372 98 14 98 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_13531_961_1152_- FIG00000047 24 5 25 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_13532_1_710_- FIG00010454 19 5 21 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_13537_1_398_+ FIG00064110 40 11 42 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_13554_1223_2005_+ FIG00003881 124 22 127 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_r2_13593_1_938_- FIG00000372 34 9 37 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_13593_1133_1513_+ FIG00007997 7 2 8 Beta-lactamase repressor BlaI Beta-lactamase 1 T2D_r2_13596_1851_2074_- FIG00046929 12 3 13 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_13598_1225_2074_+ FIG00000476 56 10 58 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_13602_1165_2074_- FIG00002320 30 12 33 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_r2_13606_1_621_+ FIG00000380 66 13 69 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_13614_1_211_+ FIG00003387 29 6 30 ABC transporter multidrug efflux pump, fused ATP-binding domains ATP-dependent efflux pump transporter Ybh 1 T2D_r2_13614_1603_2072_+ FIG00042275 86 14 87 ABC transport system, permease component YbhR ATP-dependent efflux pump transporter Ybh 1 T2D_r2_13625_1682_2071_- FIG00340292 4 2 5 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_13645_1884_2012_+ FIG00001577 9 4 10 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_r2_13743_1_380_- FIG00002320 5 4 8 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_r2_13762_1_546_+ FIG00093352 32 9 34 CRISPR-associated RecB family exonuclease Cas4a CRISPRs 1 T2D_r2_13775_383_607_+ FIG00000122 15 3 16 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_13783_1054_1485_+ FIG00024401 86 15 87 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_13783_1486_2055_+ FIG00000221 120 18 121 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_13920_1_801_- FIG00046358 172 27 184 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_13924_1359_2039_+ FIG00024401 29 9 31 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_14018_1285_1992_- FIG00002914 65 15 85 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_14031_1751_2026_+ FIG00050603 29 5 30 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_14187_1820_2028_- FIG00022976 7 2 8 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_14200_1148_2014_+ FIG00011382 44 10 47 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_r2_14204_1_236_- FIG00000387 25 5 26 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_r2_14229_563_1108_- FIG00000542 100 15 103 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_14229_1801_2022_+ FIG00000117 50 8 51 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_14232_1_283_+ FIG00000834 34 7 35 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_r2_14266_1359_2022_+ FIG00093180 3 3 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_14273_1161_1637_+ FIG00077620 12 5 13 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_14351_1143_2016_- FIG00138258 27 7 30 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_14399_426_884_+ FIG00052802 78 13 91 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_r2_14462_393_1001_+ FIG00000463 71 16 73 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_14523_1299_2002_+ FIG00018369 27 7 30 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_14536_445_849_- FIG00030174 3 3 5 Predicted arginine uptake transporter Arginine Biosynthesis extended 1.0 T2D_r2_14568_885_1355_- FIG00063189 32 7 33 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_r2_14610_1_1012_+ FIG00001649 116 24 117 N-methylhydantoinase A (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_r2_14626_1_1011_+ FIG00000147 86 21 87 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_14657_960_1319_- FIG00000157 42 9 44 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_14692_234_1172_+ FIG00000365 58 16 62 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_14772_637_915_- FIG00000962 27 7 28 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_14776_1_801_- FIG00000025 51 12 54 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_14821_1_887_+ FIG00006151 37 11 39 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_14821_1710_1981_+ FIG00047509 13 5 15 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_14841_991_1302_- FIG00031250 6 3 7 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_14867_1109_1477_+ FIG00000376 17 3 19 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_14900_928_1140_- FIG00023943 9 4 11 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_r2_14945_1_765_- FIG00022899 16 8 21 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_15045_1_490_+ FIG00001504 27 7 29 Serine--glyoxylate aminotransferase (EC 2.6.1.45) Serine-glyoxylate cycle 1 T2D_r2_15048_1_1190_+ FIG00000011 83 22 85 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_15137_1_232_+ FIG00000317 22 4 23 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_15149_1616_1959_+ FIG00001505 86 12 86 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_15178_1_894_- FIG00001469 63 17 65 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_15212_1_880_+ FIG00001307 34 8 36 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_r2_15212_1049_1953_+ FIG00031250 57 13 59 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_15297_1_476_+ FIG01955977 8 4 10 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Alkanesulfonate assimilation 9.? T2D_r2_15335_542_1159_+ FIG01016270 34 10 36 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_r2_15383_1_692_- FIG00000114 188 26 188 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_15383_708_887_- FIG00016836 30 6 30 Transcription termination protein NusB Transcription factors bacterial 1 T2D_r2_15389_1_666_+ FIG00018699 12 5 14 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_15515_447_1286_+ FIG00002470 27 7 30 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_15551_1214_1930_- FIG00028694 136 22 137 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_r2_15659_1_283_- 60 10 60 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_r2_15661_260_808_- FIG00080231 121 18 122 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_r2_15684_665_1922_- FIG00001932 13 6 16 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_15705_1027_1740_+ FIG00134135 26 7 27 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_15726_1493_1919_+ FIG00004744 87 14 88 Rare lipoprotein A precursor Peptidoglycan Biosynthesis 1.9 T2D_r2_15730_1_690_+ FIG00006542 10 6 12 FIG006542: Phosphoesterase CBSS-257314.1.peg.676 4.x T2D_r2_15764_1350_1916_+ FIG00000793 82 15 83 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_15767_1572_1916_+ FIG00006151 12 4 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_15771_523_1110_+ FIG00010738 100 16 101 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_r2_15771_1153_1915_+ FIG00000258 183 28 183 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_r2_15817_78_935_- FIG00000323 64 15 66 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_15817_941_1168_- FIG00000323 8 2 9 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_15861_1067_1909_+ FIG00000113 124 25 125 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_16003_1709_1900_+ FIG00000388 8 3 9 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_16129_1_284_+ FIG00009156 3 2 4 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_r2_16133_1_810_+ FIG00129130 64 22 67 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_r2_16133_1018_1891_+ FIG00129130 42 15 43 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_r2_16146_1_169_- FIG00003435 40 6 40 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_16222_987_1886_- FIG00000156 228 34 232 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_16261_101_796_- FIG00000038 34 7 38 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_16335_864_1028_+ FIG00001732 32 5 32 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_r2_16391_1520_1875_- FIG01318274 11 5 12 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_16447_1097_1872_+ FIG00028203 58 16 60 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_16458_946_1871_+ FIG00000122 157 27 159 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_16462_988_1392_- FIG00000156 82 13 83 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_16470_1_1042_+ FIG00018396 31 12 47 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_16501_1_440_- FIG00000174 119 17 119 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_r2_16520_1660_1867_+ FIG00000601 19 5 20 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_16541_1_552_+ FIG00073301 6 2 8 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_16553_501_791_+ FIG00002148 45 9 46 Aspartate carbamoyltransferase regulatory chain (PyrI) De Novo Pyrimidine Synthesis 1 T2D_r2_16570_1_913_- FIG00130339 207 34 207 Cytochrome c heme lyase subunit CcmF Copper homeostasis 12 T2D_r2_16570_1470_1864_- FIG00003069 82 13 83 Cytochrome c-type biogenesis protein CcmE, heme chaperone Copper homeostasis 12 T2D_r2_16571_1054_1572_+ FIG00000118 68 13 70 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_r2_16577_1_504_+ FIG00000089 54 11 56 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_r2_16577_509_1096_+ FIG00000036 51 12 54 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_16577_1114_1260_+ FIG00000036 8 3 9 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_16606_1156_1861_+ FIG00055715 174 27 174 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_16623_1_187_- FIG00004169 19 4 21 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_16648_223_828_- FIG00093180 150 24 151 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_16650_1_206_- FIG00001022 3 2 4 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_16700_965_1162_- FIG00000116 19 3 20 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_16832_1325_1675_+ FIG00001802 3 2 4 FIG001802: Putative alkaline-shock protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_16834_427_882_- FIG00000243 15 6 17 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_16845_1643_1845_+ FIG00003712 3 2 4 Fe-S-cluster-containing hydrogenase components 1 Anaerobic respiratory reductases 3 T2D_r2_16878_1168_1806_+ FIG00000404 111 19 113 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_16892_859_1230_- FIG00000121 5 4 6 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_r2_16982_783_1394_- FIG00000015 13 6 16 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_17045_389_886_- FIG00004528 17 5 18 Di-/tripeptide transporter Proton-dependent Peptide Transporters 1 T2D_r2_17055_949_1413_- FIG00002385 6 3 7 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_17081_1008_1832_+ FIG00095822 21 9 23 Pseudouridine kinase (EC 2.7.1.83) Pseudouridine Metabolism 9 T2D_r2_17142_302_1129_+ FIG00000402 104 16 106 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_17200_1357_1824_- FIG00028203 75 14 76 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_17296_1_804_+ FIG00000434 132 18 133 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_17299_1_347_- FIG00017454 11 3 14 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_17340_1_566_- FIG00002049 8 5 10 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_17340_974_1468_- FIG00006691 5 3 7 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_17403_829_1047_+ FIG00000329 37 7 38 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_17404_21_1121_- FIG00034392 36 11 40 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_17404_1410_1813_- FIG00000025 75 13 75 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_17458_1_1039_+ FIG00000341 22 8 24 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_17523_101_625_- FIG00000081 45 10 47 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_17550_1057_1398_+ FIG00000899 33 10 35 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_r2_17566_1_318_+ FIG00000025 10 6 20 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_17601_1019_1802_+ FIG00000243 12 9 15 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_17608_116_331_- FIG00002453 51 8 51 Carbon storage regulator Carbon Starvation 1.21 T2D_r2_17620_1_410_+ FIG00055715 13 4 14 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_17638_534_1052_+ FIG00000578 68 15 70 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_17659_1157_1797_+ FIG00012746 168 25 168 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_17694_631_951_- FIG00000185 37 7 38 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_17708_1103_1795_+ FIG00135025 17 5 19 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_17712_1_999_- FIG00051001 175 31 176 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Biotin biosynthesis 1X T2D_r2_17837_1_369_+ FIG01955111 35 7 35 Peptidyl-prolyl cis-trans isomerase ppiA precursor (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_r2_17854_746_1057_+ FIG00007339 5 4 6 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_r2_17904_1203_1427_- FIG00008080 9 3 10 YafQ toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_r2_17921_1223_1782_- FIG00007957 20 6 22 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_17925_415_906_- FIG00001170 37 8 38 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_r2_17928_1430_1782_+ FIG00000578 84 13 85 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_17948_1063_1449_+ FIG00000793 24 7 26 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_17948_1487_1781_+ FIG00453259 50 8 51 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_r2_18055_986_1534_- FIG00000402 21 5 22 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_18137_356_892_- FIG00031250 24 7 26 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_18155_1160_1770_+ FIG00000279 78 15 81 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_18221_1474_1766_+ FIG00003090 79 11 79 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_r2_18250_1473_1764_+ FIG00021289 13 3 14 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_18275_923_1255_- FIG01007502 12 3 15 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_18327_1_366_+ FIG00002026 19 5 20 Nucleotidase YfbR, HD superfamily Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_18378_415_915_- FIG00000863 11 4 14 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_r2_18424_1_525_+ FIG00067248 27 9 30 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_18460_1_448_- FIG00000202 58 12 60 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_18470_1102_1753_+ FIG00168885 87 14 89 Cellobiose phosphorylase (EC 2.4.1.-) Beta-Glucoside Metabolism 2.bc T2D_r2_18545_141_821_- FIG00019251 4 2 6 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_18600_882_1337_- FIG00001269 45 10 46 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_18605_1165_1704_+ FIG00028694 12 6 15 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_r2_18671_825_1040_+ FIG00846773 36 6 37 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_18791_907_1737_- FIG00025216 14 6 18 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_18839_1_772_- FIG00000782 101 17 102 Exonuclease SbcD DNA repair, bacterial 3 T2D_r2_18844_935_1396_- FIG00007373 45 9 47 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_r2_18846_1099_1734_+ FIG00064110 14 3 16 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_18869_967_1443_- FIG00002130 16 4 18 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_18916_428_1024_+ FIG00000368 148 22 148 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_r2_18920_290_820_- FIG00067300 43 10 44 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_r2_18920_855_1202_- FIG00067300 8 2 10 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_r2_18955_1409_1729_- FIG00004334 7 3 8 CRISPR-associated protein Cas2 CRISPRs 1 T2D_r2_18972_1363_1728_- FIG00006551 20 8 21 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_18974_1135_1728_+ FIG00002947 4 2 6 Chemotaxis protein CheC -- inhibitor of MCP methylation Bacterial Chemotaxis 9 T2D_r2_18991_1000_1727_+ FIG00064110 71 15 76 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_19047_1359_1723_- FIG00000025 20 6 25 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_19117_1121_1719_+ FIG01310319 6 5 11 Exoenzymes regulatory protein AepA in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_r2_19154_1305_1716_+ FIG00060517 28 5 29 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_19200_191_409_+ FIG00002958 12 4 13 FIG002958: hypothetical protein Hypothetical Coupled to RecF 1 T2D_r2_19200_573_1004_+ FIG00000412 9 3 10 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_19319_799_1008_+ FIG00004764 33 6 33 Ammonium transporter Ammonia assimilation 1 T2D_r2_19363_281_886_- FIG00000355 29 9 31 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_19404_1023_1704_+ FIG00000364 131 21 133 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) Coenzyme A Biosynthesis A.191 T2D_r2_19405_2_772_- FIG00003881 75 19 77 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_r2_19418_921_1703_- FIG00138468 32 10 34 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_19423_1_1095_+ FIG00001269 130 28 132 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_19469_1152_1700_- FIG00048014 128 20 128 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_19497_941_1204_- FIG00040817 54 8 55 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_19525_692_1099_+ FIG00001550 16 5 17 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_r2_19535_1464_1697_- FIG00132801 38 7 38 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_r2_19541_555_830_- FIG00000560 5 2 6 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_r2_19661_559_1071_+ FIG00000317 37 10 39 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_19661_1122_1690_+ FIG00000317 5 4 7 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_19667_1441_1690_+ FIG00000532 47 8 48 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_19739_1434_1687_+ FIG00001712 29 6 30 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_r2_19751_457_924_- FIG00007079 12 4 13 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_19825_967_1683_- FIG00002803 27 11 29 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_19845_949_1164_- FIG00000212 13 4 14 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_r2_19968_1_569_+ FIG00018536 57 10 58 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_20039_126_1031_+ FIG01304636 34 10 37 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_r2_20057_1285_1673_- FIG00000022 70 13 74 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_r2_20114_1_394_- FIG00000967 90 14 90 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_r2_20114_477_902_- FIG00000025 45 13 47 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_20114_923_1603_- FIG00000025 18 6 21 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_20118_583_1011_- FIG00008556 9 4 11 L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_20146_1297_1669_- FIG00000494 80 12 81 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_20192_1264_1667_- FIG00127025 92 14 92 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_r2_20205_1_938_- FIG00041382 261 36 261 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_20205_950_1667_- FIG00041382 67 12 69 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_20210_263_880_- FIG00001168 34 13 37 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_20210_913_1440_- FIG00001168 67 13 68 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_20218_571_900_- FIG00000001 12 5 13 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_20218_927_1666_- FIG00000001 49 11 51 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_20227_961_1665_- FIG01546819 56 13 57 TPP-requiring enzyme co-localized with putative O-antigen rfb gene cluster Acetoin, butanediol metabolism 5 T2D_r2_20302_465_977_- FIG00000289 70 13 70 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_20363_961_1224_- FIG00023946 29 4 30 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_20385_1453_1657_- FIG00126843 11 3 13 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_20443_1_698_- FIG00074225 192 28 192 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_20456_1482_1654_+ FIG00000555 25 4 26 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_20517_1405_1569_- FIG00132839 5 2 6 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_20542_1373_1650_+ FIG00003715 3 3 4 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_20638_1_1060_+ FIG01303880 150 27 159 Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex (EC 1.8.1.4) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_20648_910_1380_- FIG00000621 30 9 32 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_20711_1011_1643_- FIG00008230 57 14 59 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_r2_20791_1_322_- FIG00000370 88 12 88 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_20795_1172_1447_+ FIG00000477 27 5 28 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_20813_825_1004_+ FIG00034392 18 4 18 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_20824_1_942_+ FIG00002451 33 5 34 CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_20834_1_285_+ FIG00000017 44 9 46 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_20854_883_1023_+ FIG00000441 19 3 19 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_20854_1026_1636_+ FIG00000441 102 18 104 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_20869_344_973_- FIG01007502 70 16 70 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_20901_1041_1520_+ FIG00013638 28 8 30 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_20939_962_1632_- FIG00001667 9 2 12 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_r2_20945_1_969_- FIG00010771 11 7 15 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_20969_1361_1631_- FIG00057840 30 8 31 Imidazolonepropionase (EC 3.5.2.7) Histidine Degradation 1.100 T2D_r2_20984_1_913_- FIG00000355 36 9 56 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_21081_1_1217_+ FIG00040870 252 38 253 CoB--CoM heterodisulfide reductase subunit A (EC 1.8.98.1) Anaerobic respiratory reductases 3 T2D_r2_21082_986_1626_+ FIG00001189 133 20 135 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_21109_1217_1625_+ FIG00021289 40 9 41 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_21134_1_308_- FIG00000573 14 5 15 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_21162_1_890_+ FIG00000208 79 15 82 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_r2_21171_902_1192_- FIG00000149 41 7 42 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_r2_21238_1038_1619_+ FIG00000522 98 18 99 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_21245_959_1246_- FIG00003555 5 2 6 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_21254_1_347_+ FIG00229257 13 4 15 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_r2_21334_80_373_- FIG00005329 9 4 10 V-type ATP synthase subunit F (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_21341_1_723_- FIG00002049 16 10 20 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_21356_419_757_- FIG01304998 30 7 30 RND efflux system, membrane fusion protein CmeA Multidrug Resistance Efflux Pumps 1.12 T2D_r2_21413_1013_1611_+ FIG00000304 116 20 117 GTP-binding protein HflX Hfl operon 1.111 T2D_r2_21418_273_494_- FIG00000080 8 3 12 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_21429_1_294_- FIG00005547 7 4 9 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_r2_21429_1125_1610_- FIG00000025 106 15 107 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_21450_747_1058_+ FIG00040870 49 9 50 CoB--CoM heterodisulfide reductase subunit A (EC 1.8.98.1) Anaerobic respiratory reductases 3 T2D_r2_21471_1_364_+ FIG00002049 8 4 9 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_21471_367_1029_+ FIG00018865 19 9 21 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_21471_1044_1328_+ FIG00018865 6 3 8 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_21573_1_598_- FIG00136447 7 5 10 Hypothetical nudix hydrolase YeaB Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_21601_992_1213_- FIG00010524 48 8 48 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_21693_1016_1599_+ FIG00133515 19 8 20 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_21707_1_579_- FIG00001750 105 19 106 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_21714_1_474_+ FIG00138258 81 15 82 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_21721_1110_1577_+ FIG00034392 22 6 24 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_21723_1_343_- FIG00008370 86 12 86 Creatinine amidohydrolase (EC 3.5.2.10) Creatine and Creatinine Degradation 4.0 T2D_r2_21752_1_194_- FIG00005172 22 5 24 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_21810_529_912_- FIG00000040 42 8 43 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r2_21810_942_1593_- FIG00000040 90 18 91 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r2_21825_649_927_- FIG00133034 10 3 11 Excinuclease ABC subunit A paralog of unknown function DNA repair, UvrABC system 1 T2D_r2_21825_993_1593_- FIG00133034 47 10 50 Excinuclease ABC subunit A paralog of unknown function DNA repair, UvrABC system 1 T2D_r2_21833_1430_1592_- FIG00006632 15 3 16 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_r2_21859_990_1591_- FIG00001750 145 22 145 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_21884_4_897_- FIG00063325 139 20 141 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (EC 3.5.4.27) One-carbon metabolism by tetrahydropterines 5 T2D_r2_21889_1297_1590_- FIG00001667 4 3 6 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_r2_21901_1_180_+ FIG00001269 34 6 35 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_21927_702_1064_+ FIG00019415 11 4 13 Putative activity regulator of membrane protease YbbK CBSS-316057.3.peg.659 1 T2D_r2_21932_979_1572_- FIG00007960 53 12 54 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_21963_1_442_- FIG00034392 16 4 19 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_21973_1_516_+ FIG00000221 26 7 28 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_22089_542_1099_+ FIG00002511 124 18 125 Ni/Fe-hydrogenase 2 B-type cytochrome subunit Hydrogenases 2 T2D_r2_22158_989_1240_- FIG00000289 21 4 22 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_22158_1242_1579_- FIG00000069 36 9 38 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_22212_1032_1499_+ FIG00000325 58 9 59 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_22227_689_1009_+ FIG00001676 10 4 12 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_22227_1018_1509_+ FIG00001676 27 10 28 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_22273_1_923_- FIG00080955 117 21 120 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_22341_964_1203_- FIG00000377 11 3 13 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_22382_34_453_- FIG00001132 94 15 95 LSU ribosomal protein L16p (L10e) Ribosome LSU bacterial 9 T2D_r2_22391_1_600_+ FIG00016514 25 7 26 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_22429_1121_1569_+ FIG00005243 46 10 51 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_22455_904_1191_+ FIG00000423 8 3 9 Dethiobiotin synthetase (EC 6.3.3.3) Biotin biosynthesis 1X T2D_r2_22462_755_1012_+ FIG00000001 12 4 13 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_22497_877_1566_- FIG00034392 12 4 14 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_22506_1_486_- FIG00031250 3 4 5 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_22531_1_230_- FIG00000624 14 4 15 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_22538_622_843_- FIG00001133 4 2 5 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_r2_22538_882_1564_- FIG00000168 81 15 83 Transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_22547_1181_1483_+ FIG00000243 23 7 24 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_22565_693_1073_+ FIG00031250 32 7 33 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_22591_1_725_- FIG00140555 182 28 182 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_22629_1_431_- FIG00000098 35 8 36 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_22645_592_768_- FIG00000551 29 6 29 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_22645_867_1559_- FIG00000551 150 22 151 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_22652_1067_1559_- FIG00000234 29 7 31 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_22680_1_566_- FIG00046929 27 10 28 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_22791_1342_1554_- FIG01297554 23 6 24 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_r2_22874_1_758_+ FIG00005723 4 7 8 Benzoate transport protein Benzoate degradation 3 T2D_r2_22959_1_1037_- FIG00002470 32 10 35 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_22987_1_924_- FIG00000680 216 34 216 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_r2_22987_936_1546_- FIG00000680 123 20 124 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_r2_23010_1127_1545_+ FIG00001712 38 8 40 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_r2_23060_1162_1542_+ FIG00041038 33 9 35 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_23085_1_484_- FIG00140555 29 6 31 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_23092_668_931_- FIG00018561 43 8 44 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_23093_1_460_+ FIG00016818 7 4 8 Putative polyribitolphosphotransferase Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_23122_1_759_- FIG00000329 209 31 209 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_23138_1_446_- FIG00006933 3 2 4 Alpha-1,4-N-acetylgalactosamine transferase PglH (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_23148_1110_1539_- FIG00029916 89 14 90 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_r2_23182_760_1044_+ FIG00004078 63 9 64 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_23182_1047_1537_+ FIG00004078 133 19 133 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_23191_1_806_- FIG00000329 157 26 158 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_23206_359_1102_+ FIG00001269 87 18 89 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_23206_1174_1537_+ FIG00001269 30 7 32 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_23260_1_425_+ FIG00125395 22 4 24 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_23260_447_1007_+ FIG00001824 47 12 49 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_23310_1042_1332_+ FIG00000184 15 3 16 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_23326_1_313_- FIG00009496 17 7 20 Predicted endonuclease distantly related to archaeal Holliday junction resolvase CBSS-160492.1.peg.550 1 T2D_r2_23336_1_1018_+ FIG00016768 206 37 207 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_23336_1045_1531_+ FIG00016768 120 19 120 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_23359_1_846_- FIG00020766 169 27 170 Oligosaccharyltransferase PglB (EC 2.4.1.119) N-linked Glycosylation in Bacteria 2.0 T2D_r2_23359_921_1530_- FIG00020766 68 12 86 Oligosaccharyltransferase PglB (EC 2.4.1.119) N-linked Glycosylation in Bacteria 2.0 T2D_r2_23405_103_834_+ FIG00000047 152 27 153 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_23409_1_165_+ FIG00000234 14 3 15 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_23412_971_1529_- FIG00000838 17 8 19 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_23431_1_285_- FIG00006551 45 8 45 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_23452_1_252_- FIG00007658 12 3 13 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_r2_23467_1_951_- FIG00473043 28 11 33 Similar to CDP-glucose 4,6-dehydratase (EC 4.2.1.45) Acetoin, butanediol metabolism 5 T2D_r2_23477_1_442_+ FIG00001067 64 14 65 Rubrerythrin Oxidative stress 1.2 T2D_r2_23478_704_1063_+ FIG00000578 75 12 76 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_23492_815_1066_+ FIG00005022 5 2 7 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_23522_963_1169_+ FIG00009628 4 2 5 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_r2_23561_1_392_+ FIG00000531 39 9 41 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_23668_854_1520_- FIG00017431 120 19 121 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_r2_23737_521_1066_+ FIG00010844 5 2 6 Flavodoxin Flavodoxin 1 T2D_r2_23782_1_1077_+ FIG01260980 284 39 285 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_23782_1095_1515_+ FIG01260980 118 16 118 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_23872_929_1512_- FIG00000038 32 6 34 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_23880_60_1037_+ FIG00001469 25 12 30 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_23942_1_1056_+ FIG00002695 278 40 279 Biosynthetic arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_23942_1062_1510_+ FIG00002695 101 16 101 Biosynthetic arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_23947_1_196_+ FIG00073301 12 4 13 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_23951_1047_1406_+ FIG00002847 84 14 84 HflK protein Hfl operon 1.111 T2D_r2_23963_952_1508_- FIG00000134 24 8 27 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_24003_1_235_+ FIG00000076 13 3 14 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_24064_1234_1504_- FIG00130344 43 8 44 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_24066_760_915_- FIG00074196 9 2 10 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_24079_940_1504_- FIG00002020 38 11 40 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_24088_1_464_- FIG00047509 43 8 44 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_24092_500_1111_+ FIG00774823 21 4 23 Conservative hypothetical protein probably involved in hydantoin, pyrimidine utilization Hydantoin metabolism 4 T2D_r2_24099_956_1503_- FIG01260980 8 5 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_24122_1_434_- FIG00000056 64 11 66 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_r2_24122_489_782_- FIG00009229 18 6 19 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_r2_24125_1076_1372_+ FIG00000209 60 10 61 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_24126_986_1502_+ FIG00001388 8 8 27 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_r2_24196_662_1012_+ FIG01304385 7 3 8 Ribose ABC transport system, periplasmic ribose-binding protein RbsB (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_24264_1_702_- FIG00000434 150 25 151 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_24291_956_1496_- FIG00000280 55 10 56 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_24292_964_1284_- FIG00000352 34 8 36 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r2_24317_95_343_- FIG00002689 19 4 20 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_24336_1_994_- FIG00018536 234 38 236 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_24338_1052_1494_+ FIG00046929 3 3 11 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_24345_939_1073_- FIG00000578 5 2 6 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_24366_1_366_+ FIG00000107 16 5 17 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_r2_24408_1012_1492_- FIG00000388 14 4 15 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_24410_1243_1492_+ FIG00000188 13 4 14 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_r2_24428_551_1045_+ FIG01270039 43 8 44 Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_r2_24455_480_974_- FIG00001253 36 9 37 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_r2_24652_1_355_- FIG00000402 11 4 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_24668_1_846_+ FIG00022300 181 29 183 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_24766_1_820_- FIG00007079 18 5 23 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_24766_862_1236_- FIG00007079 18 4 20 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_24788_1044_1478_+ FIG00034293 41 11 42 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_24813_944_1478_- FIG00000402 51 12 53 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_24849_1_244_+ FIG00016836 7 3 9 Transcription termination protein NusB Transcription factors bacterial 1 T2D_r2_24849_248_1057_+ FIG00000323 134 25 135 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_24884_557_943_- FIG00011987 17 5 18 Stage III sporulation protein AD Sporulation Cluster III A 1.x T2D_r2_24907_1_953_- FIG00000243 148 26 149 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_25108_956_1468_- FIG00006609 61 13 62 Nickel transport ATP-binding protein NikE (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_r2_25121_958_1467_+ FIG00000065 66 13 68 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_25124_1102_1467_+ FIG00135056 94 14 94 Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2) Anaerobic respiratory reductases 3 T2D_r2_25174_971_1465_- FIG00003788 5 3 7 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_25330_299_592_+ FIG00061313 21 5 22 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_r2_25336_968_1460_- FIG00000080 76 15 77 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_25357_619_1149_+ FIG00002914 10 5 13 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_25370_12_1046_+ FIG00001307 261 39 261 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_r2_25451_1_1026_- FIG00001269 245 37 246 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_25466_1_947_- FIG00007137 29 5 32 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_25471_1144_1455_+ FIG00022631 59 10 59 Acetyl-coenzyme A synthetase (EC 6.2.1.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_25474_1_362_- FIG00003535 91 14 91 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_25525_1042_1281_+ FIG01260980 53 8 53 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_25580_285_578_- FIG00009229 21 5 22 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_r2_25645_1008_1449_+ FIG00000573 23 8 25 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_25718_87_968_- FIG00007960 23 9 28 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_25789_1_963_- FIG00000241 114 25 115 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_25789_996_1409_- FIG00000241 24 7 25 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_25812_1_1019_+ FIG00028203 83 24 84 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_25812_1152_1445_+ FIG00000080 7 4 9 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_25840_1_229_+ FIG00000877 40 8 40 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_25850_1_678_- FIG01960218 34 11 37 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_25875_338_847_- FIG00003881 83 14 85 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_r2_25877_883_1254_- FIG00000114 27 5 28 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_25930_940_1188_- FIG00000015 48 7 49 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_26057_191_577_- FIG00000540 16 5 17 Holo-[acyl-carrier protein] synthase (EC 2.7.8.7) CBSS-176299.4.peg.1292 3 T2D_r2_26188_590_1138_+ FIG00000175 22 7 24 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_r2_26379_573_899_- FIG00004764 12 3 15 Ammonium transporter Ammonia assimilation 1 T2D_r2_26379_923_1427_- FIG00004764 18 6 20 Ammonium transporter Ammonia assimilation 1 T2D_r2_26450_1_916_- FIG00000080 183 30 183 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_26452_401_1075_+ FIG00000273 147 23 148 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_r2_26459_943_1425_- FIG00093180 6 5 7 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_26484_247_1023_+ FIG00107349 202 30 203 Glycine/sarcosine/betaine reductase component C chain 1 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_26514_1_713_- FIG00000372 6 3 9 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_26518_1_793_+ FIG00030191 3 2 4 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_26522_323_1039_+ FIG00047414 133 20 134 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_26522_1054_1275_+ FIG00047414 54 8 54 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_26547_990_1422_- FIG00001932 7 3 10 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_26548_448_1176_+ FIG00116638 11 4 13 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_r2_26555_1_584_- FIG00846773 48 11 49 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_26570_1111_1407_+ FIG00052605 16 4 17 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_26631_1_203_+ FIG00000624 23 5 24 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_26631_964_1419_- FIG00000168 88 15 90 Transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_26643_1066_1419_+ FIG00000351 16 4 17 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_r2_26656_962_1393_+ FIG00846773 59 9 60 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_26759_882_1415_- FIG00006151 12 5 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_26870_1018_1412_- FIG00006463 32 9 33 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_26930_1_1015_+ FIG00020897 37 11 40 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_r2_26930_1018_1206_+ FIG00020897 3 2 4 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_r2_26934_1_518_- FIG00000314 41 11 43 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_r2_26934_523_987_- FIG00004229 40 11 41 Heptaprenyl diphosphate synthase component I (EC 2.5.1.30) Isoprenoid scratch 1 T2D_r2_27033_1_749_- FIG00000185 184 26 186 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_27034_320_826_- FIG00000145 9 5 11 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_r2_27081_1_1018_+ FIG00001088 8 3 10 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_27127_992_1404_- FIG00000343 30 7 31 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_27137_1063_1404_+ FIG00000011 33 8 35 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_27213_607_972_- FIG00022300 37 8 39 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_27216_1_830_+ FIG00000962 197 29 197 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_27254_1_995_+ FIG00023943 25 10 30 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_r2_27287_504_941_- FIG00139238 23 7 24 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_r2_27320_1_375_- FIG01303734 77 14 77 Cysteine desulfurase (EC 2.8.1.7), NifS subfamily Alanine biosynthesis A.123 T2D_r2_27320_1203_1397_- FIG00000621 53 7 53 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_27344_1_275_- FIG00000206 34 7 35 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_r2_27382_1214_1395_- FIG00022300 43 7 43 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_27428_1_348_+ FIG00012945 3 3 5 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_27430_471_989_- FIG00000370 11 7 13 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_27430_995_1354_- FIG00000370 4 3 5 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_27444_1101_1393_+ FIG01260980 85 12 85 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_27475_1_960_- FIG00000402 76 19 78 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_27506_1_741_+ FIG00031969 4 4 6 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_r2_27702_1_1024_+ FIG00000011 40 12 42 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_27722_1158_1385_+ FIG00006151 47 8 47 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_27728_1_236_- FIG00000721 21 4 22 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_27728_239_916_- FIG00002541 135 22 136 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_27735_1_396_+ FIG00000022 108 15 108 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_r2_27741_1_562_- FIG00016768 137 21 138 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_27807_124_1110_+ FIG00005204 35 12 39 Inner membrane component of tripartite multidrug resistance system Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 1 T2D_r2_27910_564_920_- FIG00001505 4 2 5 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_27910_923_1165_- FIG00001505 8 2 9 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_27920_1_173_- FIG00135315 41 6 41 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_27979_352_1122_+ FIG00000402 20 4 21 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_27979_1125_1377_+ FIG00000402 3 3 4 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_27987_1144_1377_- FIG00001358 65 9 65 Error-prone, lesion bypass DNA polymerase V (UmuC) DNA repair, bacterial UmuCD system 3 T2D_r2_28051_1_179_- FIG00000235 19 4 20 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_28090_1_723_+ FIG00018699 189 28 189 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_28098_1005_1373_+ FIG00000847 87 13 87 Allophanate hydrolase 2 subunit 1 (EC 3.5.1.54) EC699-706 1 T2D_r2_28156_234_782_+ FIG00001306 18 6 19 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_r2_28160_1_958_- FIG00006128 154 25 156 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_28160_985_1371_- FIG00006128 46 9 47 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_28246_1056_1369_+ FIG01260980 33 7 34 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_28286_1_1053_- FIG01260980 266 39 266 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_28302_1014_1367_+ FIG00044622 38 8 39 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_28314_1_287_+ FIG00000578 73 11 73 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_28356_1098_1365_+ FIG00001635 21 6 22 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_28358_1_314_- FIG00044735 3 2 4 Aminopeptidase S (Leu, Val, Phe, Tyr preference) (EC 3.4.11.24) EC 3.4.11.- Aminopeptidases 1 T2D_r2_28386_1_372_+ FIG00000343 21 6 23 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_28388_1047_1310_+ FIG00003672 28 4 30 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_r2_28395_203_1108_- FIG00561498 11 6 13 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_28434_964_1363_- FIG00010194 15 5 17 Cell wall surface anchor family protein Sortase 1.12 T2D_r2_28465_1_698_- FIG00007714 35 10 38 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_r2_28496_948_1217_- FIG00561498 18 3 20 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_28503_1_599_- FIG00001469 5 3 6 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_28509_1015_1361_+ FIG00094401 12 3 14 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_28540_854_1360_+ FIG00000176 65 10 66 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_28565_961_1284_+ FIG00132839 37 7 38 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_28609_749_1358_- FIG00138468 45 10 46 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_28671_100_468_- FIG00455853 82 13 82 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_28676_293_892_- FIG00000402 19 7 21 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_28709_1_756_+ FIG00000070 43 14 45 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_28728_1097_1355_+ FIG00018699 12 3 13 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_28732_1_313_- FIG00008941 66 10 67 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_28777_1129_1354_+ FIG00024851 15 4 16 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_28799_104_1000_- FIG00018865 19 8 22 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_28916_674_1012_+ FIG00028476 16 4 18 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_28986_599_1349_+ FIG00003784 36 15 106 Cytochrome c nitrite reductase, small subunit NrfH Nitrate and nitrite ammonification 1 T2D_r2_29006_1029_1348_+ FIG00046929 72 11 73 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_29011_229_939_- FIG00058830 137 24 139 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_29030_1137_1348_+ FIG00000243 21 5 22 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_29044_1009_1347_- FIG00003555 18 6 20 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_29075_732_1091_+ FIG00000494 9 2 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_29088_373_1128_+ FIG00000023 49 13 52 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_r2_29127_626_1120_+ FIG00000283 22 6 24 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_29188_1_1003_+ FIG00000990 84 18 86 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_29201_42_923_+ FIG00000065 132 23 133 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_29223_1101_1343_+ FIG00067681 30 7 31 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_29255_1_642_- FIG00041038 51 12 52 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_29266_787_1167_+ FIG00058830 14 3 16 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_29266_1206_1342_+ FIG00058830 13 4 14 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_29291_1065_1341_+ FIG00003086 7 3 8 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_r2_29305_385_966_- FIG00018536 28 6 29 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_29306_478_933_- FIG00000325 25 8 27 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_29342_1071_1223_+ FIG00003270 6 2 7 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_r2_29415_1_816_+ FIG00001932 87 19 91 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_29442_1_1114_+ FIG00010454 52 17 56 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_29470_872_1336_- FIG00044622 42 7 43 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_29567_1_421_+ FIG00018865 67 14 69 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_29588_1_1046_+ FIG00007960 277 39 279 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_29606_961_1200_- FIG00005172 48 8 49 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_29735_1_812_- FIG00000404 47 12 49 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_29749_1_757_+ FIG00000979 5 3 7 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_r2_29771_945_1328_- FIG00000001 13 4 15 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_29811_1043_1327_+ FIG00088067 7 2 8 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_r2_29812_655_903_- FIG00135554 63 9 63 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_r2_29815_409_999_- FIG00000426 55 16 59 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY Bacterial Chemotaxis 9 T2D_r2_29827_399_890_+ FIG00001105 5 4 6 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_r2_29844_1_1008_+ FIG00041382 286 39 286 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_29857_1_142_- FIG00000446 6 2 7 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_29911_1059_1205_+ FIG00000279 6 2 7 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_29960_921_1323_- FIG00018561 38 10 39 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_29973_1_660_+ FIG00000097 95 17 97 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_29973_703_1005_+ FIG00000401 29 8 30 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_29973_1032_1322_+ FIG00000401 52 9 53 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_29989_1_255_+ FIG00032749 13 4 17 Protein YicC CBSS-323097.3.peg.2594 1 T2D_r2_29989_313_921_+ FIG00000131 32 9 34 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_30000_209_913_- FIG00003596 39 8 41 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_r2_30034_953_1321_- FIG00000402 21 5 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_30044_430_837_- FIG00000522 77 15 77 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_30046_1_830_- FIG00001004 25 18 123 Threonine dehydratase biosynthetic (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_30046_851_1321_- FIG00001004 40 8 42 Threonine dehydratase biosynthetic (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_30065_1_483_- FIG00066425 118 19 118 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_r2_30065_941_1320_- FIG00000441 42 7 48 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_30067_974_1320_- FIG00000085 64 11 65 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_30102_528_1001_- FIG00000365 117 19 119 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_30106_650_1048_+ FIG00000824 34 7 36 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_r2_30136_1_328_+ FIG00000542 43 9 44 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_30136_497_1318_+ FIG00000001 19 6 22 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_30169_1_795_+ FIG00135554 25 10 29 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_r2_30176_1_177_+ FIG00041038 20 6 21 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_30243_575_955_- FIG00135025 7 4 8 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_30303_754_966_- FIG00000464 15 4 16 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_30303_990_1314_- FIG00000464 26 7 28 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_30348_944_1313_- FIG00001547 31 5 32 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_30419_1_1021_- FIG00010454 21 7 23 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_30443_947_1311_- FIG01261528 4 4 6 Na+/H+ antiporter NhaD type Na(+) H(+) antiporter 1 T2D_r2_30463_946_1310_- FIG00554193 19 4 21 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_30549_899_1123_- FIG00002504 17 4 18 DNA-damage-inducible protein J Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_r2_30555_1_444_+ FIG00009782 7 4 9 Putative dihydroxyacetone kinase (EC 2.7.1.29), dihydroxyacetone binding subunit Dihydroxyacetone kinases 3 T2D_r2_30606_905_1306_- FIG01260980 74 10 74 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_30636_1074_1305_+ FIG00000134 59 9 59 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_30679_594_1055_+ FIG00000070 31 10 34 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_30681_1_433_- FIG00000521 14 6 16 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_r2_30726_881_1144_+ FIG00005283 6 2 7 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_r2_30752_136_951_- FIG00066575 124 21 127 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_30793_144_833_+ FIG00004744 124 21 126 Rare lipoprotein A precursor Peptidoglycan Biosynthesis 1.9 T2D_r2_30812_937_1302_- FIG00229199 50 9 51 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_r2_30824_156_722_- FIG00001253 57 11 58 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_r2_30858_943_1300_- FIG00000356 4 2 7 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_30880_941_1300_- FIG00067681 22 4 24 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_30930_1087_1299_+ FIG00031969 31 6 32 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_r2_30933_252_476_+ FIG00000435 4 3 5 Exodeoxyribonuclease VII small subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_30940_71_520_- FIG00000261 122 18 122 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_30940_610_951_- FIG00005547 68 13 70 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_r2_30940_972_1160_- FIG00005547 27 5 27 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_r2_30957_111_740_+ FIG00000396 4 5 7 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_r2_30977_922_1298_+ FIG00000388 45 8 48 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_30990_626_967_- FIG00000352 56 9 57 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r2_30990_973_1297_- FIG00000352 48 9 49 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r2_31034_1_370_+ FIG00000376 17 5 19 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_31041_1_969_+ FIG00000560 70 17 77 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_r2_31092_51_983_- FIG00121768 48 14 54 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_31165_392_1216_+ FIG01303866 91 18 93 DNA repair exonuclease family protein YhaO DNA repair, bacterial 3 T2D_r2_31180_990_1293_- FIG00001269 30 7 31 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_31187_962_1138_- FIG00018396 27 5 27 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_31208_794_1000_+ FIG00005216 11 2 12 Sulfate permease Cysteine Biosynthesis 2.17 T2D_r2_31211_1_306_+ FIG00052605 16 3 17 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_31237_836_1054_+ FIG00561498 23 4 24 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_31255_928_1291_- FIG00007059 3 3 5 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_r2_31286_1_632_- FIG00010675 17 5 19 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_r2_31286_925_1290_- FIG00004169 37 6 39 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_31355_1_967_- FIG00000279 34 9 35 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_31391_1_1180_+ FIG00000116 222 36 235 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_31395_794_1030_+ FIG00003555 18 4 19 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_31395_1072_1286_+ FIG00003555 11 3 12 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_31447_1_212_- FIG00006128 41 7 41 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_31459_737_904_- FIG00004743 11 3 12 Lactoylglutathione lyase (EC 4.4.1.5) Methylglyoxal Metabolism 3.x T2D_r2_31459_937_1104_- FIG00004743 9 3 10 Lactoylglutathione lyase (EC 4.4.1.5) Methylglyoxal Metabolism 3.x T2D_r2_31516_1_554_- FIG00003520 58 12 59 Phage tail fiber protein Phage tail fiber proteins 2 T2D_r2_31526_1_162_+ FIG00037431 15 5 16 DNA repair protein RadC DNA repair, bacterial 3 T2D_r2_31614_899_1281_- FIG00006151 8 3 11 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_31636_649_1050_+ FIG00000243 9 5 10 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_31636_1083_1280_+ FIG00000243 18 6 19 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_31730_871_1089_- FIG00139589 11 2 13 Probable L-ascorbate-6-phosphate lactonase UlaG (EC 3.1.1.-) (L-ascorbate utilization protein G) L-ascorbate utilization (and related gene clusters) 29 T2D_r2_31746_1099_1277_+ FIG00561498 17 3 18 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_31764_718_1071_+ FIG00003086 85 11 86 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_r2_31817_1_566_- FIG00006997 24 6 27 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_r2_31817_939_1276_- FIG00005705 41 7 43 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_r2_31881_957_1274_- FIG00001642 18 6 20 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_31888_973_1236_- FIG00052605 12 3 14 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_31912_921_1273_- FIG00001548 65 10 66 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_31945_1031_1273_+ FIG00000578 52 9 52 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_31962_1_166_- FIG00002914 31 5 31 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_31992_789_1103_+ FIG00000834 47 8 48 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_r2_32061_1_427_- FIG00000001 4 3 6 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_32154_969_1217_- FIG00000412 49 7 50 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_32201_940_1267_- FIG00006699 22 6 24 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_r2_32247_1_645_+ FIG01955850 168 26 168 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_32336_1_172_- FIG00008507 16 3 17 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_r2_32352_1_434_- FIG00000070 23 8 24 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_32357_1_428_- FIG00032749 11 4 13 Protein YicC CBSS-323097.3.peg.2594 1 T2D_r2_32357_545_865_- FIG00000387 8 3 10 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_r2_32357_979_1263_- FIG00000387 41 8 43 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_r2_32363_1_925_- FIG00009682 67 11 68 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_32363_949_1263_- FIG00009682 40 9 40 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_32417_561_938_- FIG00052730 16 4 17 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_r2_32435_695_1063_+ FIG00000773 53 9 54 Glutamyl-tRNA synthetase (EC 6.1.1.17) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_32435_1123_1261_+ FIG00000773 27 5 27 Glutamyl-tRNA synthetase (EC 6.1.1.17) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_32457_1_819_+ FIG00000113 197 31 199 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_32534_1_788_- FIG00000404 28 6 30 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_32534_869_1259_- FIG00000404 10 3 12 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_32543_595_1023_+ FIG00134135 19 7 20 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_32543_1035_1259_+ FIG00134135 11 3 12 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_32556_1_594_- FIG00022976 32 12 33 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_32565_615_1031_+ FIG00000011 83 14 83 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_32565_1043_1258_+ FIG00000011 51 8 51 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_32638_396_1031_+ FIG00018561 61 14 63 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_32705_1_1081_- FIG00000025 7 6 10 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_32708_1_149_- FIG00130900 38 6 38 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_r2_32708_283_516_- FIG00004843 66 9 66 Protein YidD Cell Division Subsystem including YidCD 1 T2D_r2_32708_528_1001_- FIG00092649 79 12 81 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_r2_32779_884_1030_+ FIG00026006 28 4 28 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_32808_1_694_+ FIG00044622 105 19 108 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_32808_1040_1253_+ FIG00000897 10 4 11 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_r2_32809_1_349_+ FIG00001025 3 2 5 Urease accessory protein UreF Urease subunits 1.x T2D_r2_32819_1_728_- FIG00001354 151 23 156 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_r2_32821_1_299_+ FIG00002252 7 3 9 Galactose/methyl galactoside ABC transport system, D-galactose-binding periplasmic protein MglB (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_32822_11_973_- FIG00133978 16 9 18 Ureidoglycolate dehydrogenase (EC 1.1.1.154) Allantoin Utilization X T2D_r2_32822_1005_1253_- FIG00031250 45 8 45 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_32852_428_928_- FIG00005698 14 5 15 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_r2_32853_524_976_- FIG00030191 7 3 10 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_32862_1050_1252_+ FIG00006463 3 3 4 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_32898_1_265_+ FIG00044622 24 6 25 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_32937_160_999_- FIG00000825 188 30 190 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_32944_1_1209_+ FIG00000392 169 30 170 Transcription termination factor Rho Transcription factors bacterial 1 T2D_r2_32947_45_1022_- FIG00459778 86 16 94 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_32957_45_884_- FIG00028694 56 17 58 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_r2_32957_905_1250_- FIG00028694 11 3 12 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_r2_32974_1_1066_+ FIG00001294 26 8 28 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_r2_33033_1_643_- FIG00000287 158 24 158 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_33056_1_228_- FIG00041382 30 5 31 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_33058_1_1247_+ FIG00001385 271 40 272 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_33079_872_1012_+ FIG00001065 8 3 8 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_33178_21_491_+ FIG00000209 115 18 115 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_33212_1_1035_+ FIG00000102 121 25 153 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_33221_994_1244_- FIG00109688 12 2 13 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_r2_33225_1_958_- FIG00000866 58 16 60 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r2_33225_970_1244_- FIG00000866 7 2 8 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r2_33232_1_616_+ FIG00000117 170 24 170 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_33245_460_1167_+ FIG00000555 32 7 34 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_33264_628_978_- FIG00000770 89 13 89 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_r2_33284_1_175_- FIG00017454 36 6 36 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_33294_1067_1242_+ FIG00011114 39 6 39 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_33355_1_174_+ FIG00000380 45 7 45 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_33356_1_269_+ FIG00000065 27 6 28 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_33369_6_893_+ FIG00059426 184 28 185 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_r2_33402_453_926_- FIG00000777 29 8 31 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_33461_1_845_+ FIG00000097 205 31 209 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_33487_873_1238_- FIG00106663 30 6 31 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_33567_1_946_+ FIG00003587 232 37 232 Radical SAM domain heme biosynthesis protein Heme biosynthesis orphans 3 T2D_r2_33570_1_426_- FIG00000224 30 7 31 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r2_33570_436_987_- FIG00001960 113 16 115 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_r2_33584_1_216_- FIG00080955 5 3 7 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_33647_1_303_+ FIG00000370 28 8 29 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_33665_532_900_- FIG00000260 38 8 39 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_33665_927_1235_- FIG00000260 34 7 35 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_33672_1_170_+ FIG00000206 37 6 37 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_r2_33713_366_1001_+ FIG00000877 36 9 45 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_33715_96_725_+ FIG00044013 139 19 140 Low molecular weight protein-tyrosine-phosphatase Wzb (EC 3.1.3.48) Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_r2_33715_1047_1233_+ FIG00006955 43 7 43 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_r2_33727_1_250_- FIG00000216 38 7 38 LSU ribosomal protein L20p Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins) 1 T2D_r2_33744_968_1233_- FIG00000782 15 4 16 Exonuclease SbcD DNA repair, bacterial 3 T2D_r2_33797_1_552_- FIG00143645 165 22 165 Pup ligase PafA' paralog, possible component of postulated heterodimer PafA-PafA' Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_r2_33959_125_880_- FIG00138208 127 23 127 Glycolate dehydrogenase (EC 1.1.99.14), subunit GlcD Glycolate, glyoxylate interconversions ? T2D_r2_34005_362_982_- FIG00000404 132 22 133 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_34023_341_631_- FIG00001011 5 2 7 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_r2_34049_905_1227_- FIG00005727 38 7 39 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_34062_1_389_+ FIG00134060 28 7 30 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_34068_1_165_- FIG00005628 9 3 11 KH domain RNA binding protein YlqC KH domain RNA binding protein YlqC 1.11 T2D_r2_34068_190_438_- FIG00000193 25 7 26 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_r2_34068_960_1226_- FIG00000113 23 5 24 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_34082_959_1226_- FIG00133139 11 4 12 Superoxide dismutase [Fe] (EC 1.15.1.1) Oxidative stress 1.2 T2D_r2_34111_8_580_+ FIG00133515 29 6 30 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_34111_613_1008_+ FIG00001054 35 10 37 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_34111_1095_1225_+ FIG00001054 6 2 7 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_34159_1067_1224_- FIG01260980 30 5 30 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_34357_1005_1220_+ FIG00023369 3 2 6 Chaperone protein DnaK Protein chaperones 2.0 T2D_r2_34397_390_887_- FIG00000176 67 12 68 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_34404_187_1077_+ FIG00000824 182 30 183 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_r2_34461_900_1217_- FIG00024930 19 3 21 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_34506_949_1216_- FIG00024401 14 3 15 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_34516_1_330_+ FIG00000287 36 7 39 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_34522_155_961_- FIG00001170 9 2 12 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_r2_34522_979_1122_- FIG00001170 6 2 7 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_r2_34534_782_1015_+ FIG00000036 14 3 15 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_34569_1_517_- FIG00008736 4 4 7 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_34584_548_1215_+ FIG00000456 30 8 31 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_r2_34593_616_978_- FIG00001636 40 7 40 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_r2_34617_1_252_- FIG00024930 32 6 36 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_34641_1_1213_+ FIG00138205 280 40 281 Uptake hydrogenase large subunit (EC 1.12.99.6) Hydrogenases 2 T2D_r2_34691_1011_1212_+ FIG00001642 13 5 14 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_34753_27_1013_+ FIG00000084 260 38 261 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_r2_34767_1_528_+ FIG00000134 34 9 36 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_34770_1_675_- FIG00000402 69 13 71 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_34845_1_785_- FIG00001280 173 28 173 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_r2_34858_799_1029_+ FIG00001667 26 5 27 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_r2_34858_1059_1209_+ FIG00001667 20 5 20 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_r2_34921_1_816_- FIG00019251 196 31 196 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_34921_828_1208_- FIG00019251 51 7 52 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_34990_523_960_- FIG01954097 4 3 6 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_35054_1_205_- FIG00018369 7 2 8 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_35085_1029_1203_+ FIG00133325 10 3 12 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_r2_35113_865_1203_- FIG00000011 16 4 20 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_35155_431_961_- FIG01343192 17 5 24 Polysaccharide ABC transporter, ATP-binding protein Rhamnose containing glycans 4.1 T2D_r2_35198_272_877_- FIG00000260 45 11 47 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_35239_580_903_- FIG00047509 31 8 33 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_35270_987_1200_- FIG00007960 57 8 57 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_35279_945_1200_- FIG00125395 50 8 51 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_35316_1_803_+ FIG01290653 126 24 126 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_35395_189_1031_+ FIG00002130 17 6 19 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_35422_893_1024_+ FIG00000080 5 2 7 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_35422_1054_1196_+ FIG00000080 4 2 4 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_35431_1_222_+ FIG00032749 15 3 16 Protein YicC CBSS-323097.3.peg.2594 1 T2D_r2_35431_233_496_+ FIG00003307 21 4 22 FIG003307: hypothetical protein CBSS-323097.3.peg.2594 1 T2D_r2_35431_520_1020_+ FIG00000131 23 5 24 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_35527_575_1153_+ FIG00132839 55 9 57 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_35594_1_539_+ FIG00133515 73 14 73 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_35604_756_1016_+ FIG00007960 10 4 12 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_35634_1_924_- FIG01290464 101 17 103 Flagellar motor switch protein FliM Bacterial Chemotaxis 9 T2D_r2_35656_240_1085_- FIG00001168 127 25 140 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_35658_378_1022_+ FIG00000069 42 12 45 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_35677_1_200_- FIG00000967 16 4 17 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_r2_35677_401_832_+ FIG00106663 3 2 4 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_35681_106_936_- FIG01955967 179 30 179 L-alanine-DL-glutamate epimerase Muconate lactonizing enzyme family 1 T2D_r2_35696_1_690_+ FIG00019212 6 2 9 Cobalt-precorrin-6x reductase (EC 1.3.1.54) Cobalamin synthesis 2 T2D_r2_35697_1_683_+ FIG00006151 54 15 55 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_35721_1_452_+ FIG00088996 86 14 87 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_r2_35728_1_269_+ FIG00000189 29 7 30 LSU ribosomal protein L27p CBSS-176279.3.peg.868 1.x T2D_r2_35732_1_365_+ FIG00000283 69 11 70 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_35790_391_669_+ FIG00002412 19 5 21 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_r2_35816_980_1188_- FIG00000165 14 4 15 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r2_35892_1_947_- FIG01260980 47 15 48 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_35892_977_1186_- FIG01260980 8 4 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_35894_1_292_+ FIG00000476 25 6 26 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_35993_398_940_+ FIG00000103 53 10 56 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_36057_1_248_+ FIG00002463 5 2 7 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_r2_36100_1_212_- FIG00000040 49 8 49 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r2_36100_1025_1182_+ FIG00000245 6 2 8 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_36110_1_316_- FIG00001036 71 11 71 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_r2_36143_1_1182_+ FIG00026918 19 9 27 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_36164_1_1181_- FIG00003433 20 5 22 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_r2_36282_461_766_+ FIG00000198 6 4 7 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_r2_36282_799_1035_+ FIG00000174 27 6 28 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_r2_36355_960_1178_- FIG00001385 3 2 4 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_36358_718_999_- FIG00000387 14 5 15 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_r2_36411_645_995_- FIG00030006 97 14 97 ATP-dependent DNA helicase SCO5183 DNA repair, bacterial RecBCD pathway 3 T2D_r2_36426_965_1176_+ FIG00011114 4 2 6 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_36428_1_486_- FIG00009682 39 12 41 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_36435_1_327_- FIG00132994 82 12 82 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_36447_1_202_- FIG00005860 14 2 15 SusD, outer membrane protein Cellulosome 1.x T2D_r2_36532_962_1174_- FIG00024401 18 4 20 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_36566_1_1107_+ FIG00006699 45 14 47 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_r2_36599_527_883_- FIG00135554 58 10 59 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_r2_36641_586_1065_+ FIG00003881 53 10 56 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_r2_36658_856_1171_- FIG00000521 23 5 24 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_r2_36672_1_432_+ FIG00058830 20 6 23 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_36678_20_616_- FIG00000190 71 15 73 Recombination protein RecR DNA processing cluster 1.1 T2D_r2_36678_632_916_- FIG00000557 31 7 32 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_r2_36716_1_485_- FIG00001146 125 19 125 GTP cyclohydrolase I (EC 3.5.4.16) type 2 Zinc regulated enzymes 1 T2D_r2_36716_494_1170_- FIG00001771 102 16 104 Nickel responsive regulator NikR Transport of Nickel and Cobalt 7 T2D_r2_36749_1_865_- FIG00000333 75 20 76 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_36753_1042_1170_+ FIG00139262 31 5 31 Poly(glycerol-phosphate) alpha-glucosyltransferase (EC 2.4.1.52) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_36766_622_1134_+ FIG00001134 29 6 30 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_r2_36788_1_508_- FIG00459778 114 18 115 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_36830_1037_1168_- FIG01031896 6 3 7 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_r2_36840_950_1168_- FIG00001548 12 3 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_36961_424_951_- FIG00000038 40 10 42 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_36961_975_1166_- FIG00000038 15 4 18 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_37046_911_1164_- FIG00076542 34 5 35 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_r2_37153_498_803_- FIG00000504 79 11 79 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_37175_1_456_- FIG00018536 14 6 16 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_37222_781_1161_- FIG00009628 49 8 51 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_r2_37245_24_737_- FIG00018699 90 17 92 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_37287_666_890_- FIG00002214 4 2 5 Xylose activator XylR (AraC family) Xylose utilization 1 T2D_r2_37314_94_747_- FIG00002561 43 10 45 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_37326_1_1056_+ FIG00018457 3 4 6 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_37359_655_1038_+ FIG00018392 19 5 24 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_r2_37442_667_1157_+ FIG00002464 54 11 56 NAD-dependent formate dehydrogenase beta subunit Formate hydrogenase 3.1?? T2D_r2_37467_840_1010_+ FIG00000422 8 2 9 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_37503_1_981_+ FIG00002194 183 34 184 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_r2_37543_1_594_- FIG00000494 27 8 29 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_37577_1006_1154_+ FIG00070513 4 2 5 phosphotransbutyrylase (EC 2.3.1.19) Acetyl-CoA fermentation to Butyrate A T2D_r2_37578_121_621_+ FIG00002823 10 3 11 L-proline glycine betaine binding ABC transporter protein ProX (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_37585_998_1154_+ FIG00000395 14 2 15 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_37613_643_975_- FIG00007960 18 4 20 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_37613_981_1154_- FIG00007960 20 4 21 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_37635_853_990_- FIG00001932 8 2 9 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_37670_237_1153_- FIG00008490 101 22 112 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_37674_1_299_+ FIG00000055 15 5 16 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_r2_37680_1_909_+ FIG00106663 35 11 37 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_37694_1_913_- FIG00004518 163 29 164 tRNA nucleotidyltransferase, A-adding (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_37755_1_278_+ FIG00000070 16 4 18 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_37815_1_1064_+ FIG00021407 45 13 47 (R)-citramalate synthase (EC 2.3.1.182) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_37848_242_517_+ FIG00001269 15 4 17 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_37878_1_149_- FIG00000380 24 5 25 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_37898_398_1048_+ FIG00002920 17 5 19 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_r2_37941_1_620_- FIG00000043 64 14 65 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_37948_1_715_+ FIG00017431 18 4 22 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_r2_37956_705_1007_+ FIG00134167 24 7 26 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_37958_1_679_- FIG00041382 169 25 169 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_38020_161_1146_+ FIG00003435 159 27 161 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_38115_460_1059_+ FIG00009149 3 4 7 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_38140_1_241_+ FIG00001366 4 2 6 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_r2_38222_927_1143_- FIG00000080 38 6 39 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_38236_1_227_- FIG00004453 46 7 46 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_r2_38275_1_790_+ FIG00000084 124 21 140 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_r2_38276_1_216_+ FIG00004334 10 2 11 CRISPR-associated protein Cas2 CRISPRs 1 T2D_r2_38460_734_1084_+ FIG00076285 60 10 61 Substrate-specific component STY3230 of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_r2_38489_940_1138_- FIG00475203 5 2 6 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_r2_38547_1_431_- FIG00010844 110 16 110 Flavodoxin Flavodoxin 1 T2D_r2_38671_967_1135_- FIG00000165 29 5 30 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r2_38676_938_1135_- FIG00000028 20 5 21 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r2_38704_326_889_- FIG00085033 23 7 26 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_r2_38717_411_1109_+ FIG00035893 3 4 8 Nickel ABC transporter, periplasmic nickel-binding protein NikA (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_r2_38725_974_1134_- FIG01955899 6 2 7 Cellobiose phosphotransferase system YdjC-like protein Beta-Glucoside Metabolism 2.bc T2D_r2_38784_118_1071_+ FIG00043259 11 5 14 Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18) Inositol catabolism 5.x T2D_r2_38806_1_238_- FIG00000621 22 6 24 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_38822_1_997_- FIG00061313 97 25 164 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_r2_38855_1_1132_- FIG00437351 10 8 13 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_r2_38904_1_1119_+ FIG00132839 204 34 205 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_38920_1_1047_- FIG00002066 40 13 44 Cytoplasmic alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_38925_528_1094_+ FIG00134135 34 8 35 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_38942_1_398_- FIG00019251 18 5 19 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_38954_614_859_- FIG00001020 6 3 7 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_39040_1_171_- FIG00000556 22 4 23 2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55) Chorismate Synthesis 1 T2D_r2_39067_1_430_+ FIG00000069 40 8 41 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_39086_1_958_- FIG00136692 227 34 227 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_39088_946_1128_- FIG00034293 23 4 24 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_39110_772_1023_+ FIG00001676 18 3 19 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_39290_979_1124_- FIG00059211 19 4 20 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_39292_1_1113_+ FIG00132839 278 39 279 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_39311_1_909_- FIG00009149 4 4 6 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_39328_1_243_+ FIG00000193 59 9 59 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_r2_39328_617_961_+ FIG00000312 52 8 53 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_r2_39366_648_1123_- FIG00024073 7 3 9 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_39436_389_835_- FIG00000510 11 4 16 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_r2_39443_212_1063_- FIG00000962 42 10 43 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_39477_377_667_+ FIG01285094 10 2 12 Lysine decarboxylase (EC 4.1.1.18) Lysine degradation 1.0 T2D_r2_39530_1_806_- FIG00133229 3 3 5 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_r2_39551_1_1016_+ FIG00000548 97 23 136 3-polyprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_39570_11_271_+ FIG00000834 17 5 18 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_r2_39589_1_1119_+ FIG00000114 108 24 116 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_39664_987_1118_- FIG01260980 11 3 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_39692_412_789_+ FIG00000832 22 5 25 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_r2_39708_1_883_+ FIG00002034 18 5 20 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_r2_39719_435_968_- FIG00004172 17 4 19 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_39780_1_145_- FIG00000409 23 4 23 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_r2_39780_149_661_- FIG00000155 124 20 124 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_r2_39780_663_965_- FIG00000200 64 11 64 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_r2_39803_493_1116_- FIG00140555 17 4 19 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_39860_1_517_+ FIG00132994 133 19 135 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_39881_358_966_- FIG00067681 140 21 141 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_39889_89_913_- FIG00000877 78 19 80 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_39900_1_1114_+ FIG00047414 170 29 172 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_39903_923_1114_- FIG00000578 12 3 13 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_39974_1_530_+ FIG00000226 54 11 55 GTP cyclohydrolase I (EC 3.5.4.16) type 1 Zinc regulated enzymes 1 T2D_r2_39997_1_170_+ FIG00598409 5 2 11 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_r2_40000_80_991_- FIG00016768 205 34 207 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_40103_1_966_- FIG00016768 250 38 250 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_40126_721_963_- FIG00001106 11 2 12 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_r2_40131_1_382_+ FIG00002920 25 8 26 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_r2_40133_131_1090_+ FIG01304636 222 33 222 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_r2_40140_165_1004_+ FIG00000268 120 23 121 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_40157_267_1013_+ FIG00002847 184 28 184 HflK protein Hfl operon 1.111 T2D_r2_40158_340_1002_+ FIG00044622 49 8 51 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_40275_1_141_- FIG00000433 28 5 28 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_40312_1_522_- FIG00024401 27 8 28 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_40337_250_417_+ FIG00011272 46 6 46 Prolyl endopeptidase (EC 3.4.21.26) EC 3.4.21.- Serine endopeptidase 1 T2D_r2_40350_1_331_- FIG00000314 5 3 6 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_r2_40374_1_918_- FIG00080955 62 12 66 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_40385_179_1042_+ FIG00006764 230 32 231 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_r2_40397_60_992_- FIG00133292 224 34 224 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_40408_19_216_- FIG00000155 17 4 18 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_r2_40421_400_873_- FIG00000261 16 5 17 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_40447_378_1040_+ FIG00000672 121 21 123 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_40496_705_1022_+ FIG00007025 5 3 6 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_40500_1_913_- FIG00000380 13 3 15 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_40545_111_443_+ FIG00001311 8 2 9 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_r2_40546_1_219_+ FIG00121768 5 3 6 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_40550_571_1002_+ FIG00001469 11 2 13 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_40578_93_1043_+ FIG00023004 54 14 55 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_40598_1_274_- FIG00000659 19 6 20 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_40625_1_455_+ FIG00133227 5 2 6 N-acetylneuraminate lyase (EC 4.1.3.3) Sialic Acid Metabolism 1.x T2D_r2_40645_740_1009_- FIG00002161 62 10 62 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_r2_40676_855_1010_+ FIG00000482 15 4 15 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_40680_871_1101_- FIG00044622 17 3 18 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_40693_409_1101_- FIG00000404 48 11 51 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_40714_910_1100_- FIG00066425 10 2 11 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_r2_40717_1_473_- FIG00000147 47 11 48 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_40768_1_656_- FIG01260980 68 15 69 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_40813_1_1003_+ FIG00000402 94 22 96 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_40815_1_992_- FIG00000532 63 17 66 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_40826_1_936_- FIG00067681 133 23 134 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_40858_1_372_- FIG00503691 84 13 85 Cadmium-transporting ATPase (EC 3.6.3.3) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_40949_1_266_+ FIG00000834 5 3 7 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_r2_40991_683_1095_+ FIG01260980 79 12 80 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_41058_1_188_- FIG00001088 43 7 43 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_41074_1_294_+ FIG00011102 13 4 15 Nitrite reductase probable electron transfer 4Fe-S subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_r2_41085_842_1093_- FIG00000268 32 6 33 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_41122_1_441_+ FIG00003672 35 8 36 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_r2_41150_1_496_+ FIG00020185 106 17 106 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_41150_558_1092_+ FIG00006551 77 14 79 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_41161_626_1018_+ FIG00000621 32 8 33 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_41297_1_1045_+ FIG00000132 122 23 124 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_41316_1_302_- FIG00000542 63 11 64 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_41341_1_1089_+ FIG00018457 11 7 13 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_41373_787_1088_+ FIG00000463 7 3 8 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_41380_1_828_+ FIG00000985 27 7 30 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_r2_41410_1_402_+ FIG00062547 19 5 21 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_r2_41423_105_665_- FIG00000277 3 2 5 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_r2_41572_934_1085_- FIG00000542 8 2 9 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_41643_861_1084_- FIG00000245 28 5 29 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_41670_293_478_+ FIG00000017 33 5 34 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_41688_190_1084_+ FIG01176807 206 32 219 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_41694_406_621_+ FIG00945384 5 3 6 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_41713_523_1083_+ FIG00003472 49 12 50 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_41730_684_1034_+ FIG01280345 22 4 23 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_r2_41775_481_1008_+ FIG00000358 59 13 60 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_r2_41881_1_371_- FIG00000494 17 5 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_41881_437_1080_- FIG00000494 28 6 31 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_41933_1_1020_+ FIG00000080 189 32 191 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_42045_1_413_+ FIG00001893 8 3 10 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_r2_42054_1_444_+ FIG00000261 26 8 28 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_42083_257_1077_+ FIG00001188 53 14 55 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_r2_42190_876_1010_+ FIG00006463 18 4 19 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_42229_1_612_+ FIG00023946 16 4 19 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_42230_1_386_+ FIG00009628 46 9 47 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_r2_42288_527_1074_- FIG00000317 33 7 35 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_42320_1_907_+ FIG00073301 74 19 76 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_42385_1_1005_+ FIG00000011 72 16 99 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_42420_1_1072_- FIG00002470 30 10 34 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_42506_1_581_- FIG00001209 44 10 63 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_42508_359_661_- FIG00000422 73 10 75 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_42527_1_830_+ FIG00121995 53 14 55 L-lactate dehydrogenase (EC 1.1.2.3) L-rhamnose utilization 1 T2D_r2_42580_1_334_- FIG00077620 18 6 21 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_42597_1_435_+ FIG00745599 37 8 40 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_r2_42622_1_732_- FIG00059211 29 8 32 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_42625_1_196_+ FIG00000764 3 2 4 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_r2_42634_227_880_+ FIG00000538 168 25 169 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_r2_42644_492_980_- FIG00130344 67 13 68 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_42797_1_377_- FIG00006463 33 10 34 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_42802_1_185_- FIG00003596 12 2 13 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_r2_42808_612_1067_+ FIG00001385 5 5 7 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_42838_580_924_+ FIG00000163 5 2 7 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_42928_732_1065_- FIG00011106 70 10 71 BatE CBSS-345072.3.peg.1318 1 T2D_r2_42929_1_594_- FIG00075702 73 16 75 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_42936_1_213_+ FIG00001642 12 3 13 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_42948_58_1014_+ FIG00016187 45 14 48 Arginine utilization protein RocB Arginine and Ornithine Degradation 1.34 T2D_r2_42999_1_1064_+ FIG00007957 168 32 169 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_43004_1_372_- FIG00132715 7 5 13 Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9) Polyhydroxybutyrate metabolism 5.6 T2D_r2_43015_1_485_+ FIG00002224 3 4 5 protein from nitrogen regulatory protein P-II (GLNB) family, ortholog YAAQ B. subtilis CBSS-393133.3.peg.2787 1 T2D_r2_43051_865_1063_+ FIG00006151 14 3 15 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_43053_706_1002_+ FIG00020185 35 8 36 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_43095_1_266_- FIG01956356 30 8 31 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_r2_43143_95_964_- FIG00000350 11 6 12 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_43178_1_744_+ FIG00024999 9 5 11 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Alkanesulfonate assimilation 9.? T2D_r2_43190_246_833_+ FIG00000151 36 8 38 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_r2_43200_695_1012_+ FIG00000086 31 5 32 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_r2_43224_1_183_+ FIG00041382 16 4 17 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_43224_209_553_+ FIG00003712 30 7 32 Fe-S-cluster-containing hydrogenase components 1 Anaerobic respiratory reductases 3 T2D_r2_43250_1_254_+ FIG00135056 43 6 43 Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2) Anaerobic respiratory reductases 3 T2D_r2_43250_374_613_+ FIG00590542 51 7 51 Adenylylsulfate reductase beta-subunit (EC 1.8.99.2) Anaerobic respiratory reductases 3 T2D_r2_43267_1_602_+ FIG00004453 175 24 175 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_r2_43309_527_1059_- FIG00000139 84 15 88 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_43314_921_1059_- FIG00000356 9 2 10 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_43315_67_678_+ FIG00003090 172 24 172 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_r2_43358_1_429_- FIG00067681 12 3 13 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_43382_1_360_+ FIG00034392 10 6 12 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_43384_1_1058_+ FIG00063189 59 20 111 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_r2_43419_1_311_- FIG01260980 12 5 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_43433_1_447_- FIG00000350 11 5 13 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_43490_1_341_+ FIG00004021 30 6 31 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_r2_43497_39_389_+ FIG00014907 6 3 7 Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_43538_1_991_- FIG00034293 166 29 167 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_43565_1_988_- FIG00136193 249 38 249 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_r2_43597_1_483_+ FIG00025216 89 16 90 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_43604_1_737_- FIG00000456 25 8 28 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_r2_43630_1_518_- FIG00000184 45 7 46 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_43673_730_1054_- FIG00936929 19 3 20 Putative phosphate ABC transporter, phosphate-binding component High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_43744_292_873_- FIG00002026 38 10 40 Nucleotidase YfbR, HD superfamily Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_43756_844_1052_+ FIG01280345 10 2 11 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_r2_43781_880_1052_+ FIG00000185 13 3 14 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_43787_1_156_+ FIG00000601 4 2 5 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_43792_123_1004_+ FIG00067681 14 5 16 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_43808_838_1051_- FIG00001656 10 3 14 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_r2_43965_759_1049_- FIG00000164 3 3 4 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_r2_44036_1_1023_+ FIG00046929 114 20 125 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_44063_1_420_+ FIG00002541 11 3 12 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_44063_463_708_+ FIG00002541 11 3 13 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_44063_789_1048_+ FIG00000721 20 4 23 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_44068_1_393_- FIG00000290 60 9 62 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_r2_44068_590_1048_- FIG00007957 35 8 37 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_44090_54_1047_+ FIG00000165 143 27 144 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r2_44184_845_1046_+ FIG00034293 36 6 37 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_44196_1_328_- FIG00002954 42 8 43 Phosphonopyruvate decarboxylase (EC 4.1.1.82) Phosphonate metabolism 1 T2D_r2_44394_1_308_- FIG00060517 24 6 25 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_44419_1_357_- FIG00000395 71 11 73 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_44431_606_1042_- FIG00000504 68 12 69 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_44478_816_1042_- FIG00126843 8 2 9 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_44511_1_1041_- FIG00001022 89 18 92 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_44513_185_772_- FIG00000001 29 8 37 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_44531_1_1008_+ FIG00000139 210 33 212 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_44569_551_1040_- FIG00058189 6 2 8 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_r2_44638_1_767_- FIG00000147 97 21 99 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_44696_1_970_- FIG00002344 76 20 78 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r2_44716_275_937_+ FIG00003555 159 24 159 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_44723_636_1004_+ FIG00000258 53 11 55 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_r2_44732_287_1038_- FIG00000448 145 26 145 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_44768_1_726_- FIG00031250 4 4 7 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_44776_1_720_+ FIG00001548 210 29 210 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_44853_391_666_+ FIG00002412 19 7 21 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_r2_44883_1_340_+ FIG00000264 70 12 70 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_r2_44914_127_1035_+ FIG00000842 24 9 27 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_r2_44963_1_426_- FIG00000122 55 13 56 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_44967_1_747_- FIG00059211 74 15 78 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_45029_1_1033_- FIG00000289 42 13 45 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_45037_1_153_- FIG00000191 26 5 26 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_45081_1_432_+ FIG00133778 63 11 64 Putative TolA protein Ton and Tol transport systems 2 T2D_r2_45094_43_534_- FIG00024073 18 4 19 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_45137_493_723_+ FIG00001469 8 3 10 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_45139_888_1032_- FIG00024851 25 4 25 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_45159_1_1031_- FIG00035175 235 36 235 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_45260_1_135_+ FIG00000141 5 3 6 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_r2_45354_1_598_+ FIG00002803 12 6 13 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_45354_624_1004_+ FIG00000449 30 8 31 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_r2_45377_398_949_+ FIG00000459 76 15 78 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_45415_132_668_- FIG00000367 20 8 22 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_r2_45418_1_424_- FIG00017454 111 17 111 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_45433_1_437_+ FIG00022300 49 12 50 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_45491_1_1027_- FIG00008370 77 11 79 Creatinine amidohydrolase (EC 3.5.2.10) Creatine and Creatinine Degradation 4.0 T2D_r2_45602_446_1026_+ FIG00135469 7 3 8 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_r2_45610_576_1010_- FIG00001146 125 17 125 GTP cyclohydrolase I (EC 3.5.4.16) type 2 Zinc regulated enzymes 1 T2D_r2_45648_652_1025_+ FIG00002489 11 5 13 Spore germination protein GerKA Spore germination 1 T2D_r2_45661_1_392_- FIG00001054 52 10 54 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_45724_1_150_- FIG00000069 20 4 20 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_45822_1_713_- FIG00011659 7 7 11 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_r2_45827_782_1022_+ FIG00031250 14 4 15 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_45840_26_829_+ FIG00024851 199 28 199 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_45842_1_803_- FIG00000402 25 7 28 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_45851_568_1022_+ FIG00000001 23 7 25 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_45927_1_878_- FIG00000333 128 23 130 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_45951_1_1021_+ FIG00000056 191 33 192 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_r2_45974_508_1002_+ FIG00000877 74 14 76 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_45988_1_1020_+ FIG00030191 85 18 86 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_45997_816_968_- FIG00002148 3 2 4 Aspartate carbamoyltransferase regulatory chain (PyrI) De Novo Pyrimidine Synthesis 1 T2D_r2_46016_632_1020_- FIG00007586 3 2 5 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_46041_528_1019_- FIG00554193 53 10 54 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_46099_864_1018_+ FIG00553949 26 5 27 H(+)/Cl(-) exchange transporter ClcA Flavohaemoglobin 1 T2D_r2_46102_81_1018_+ FIG00004764 67 19 69 Ammonium transporter Ammonia assimilation 1 T2D_r2_46119_1_524_+ FIG00000212 22 7 23 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_r2_46129_1_470_- FIG00004518 88 16 89 tRNA nucleotidyltransferase, A-adding (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_46129_807_1018_+ FIG00000017 8 2 9 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_46150_330_1018_- FIG00018369 121 21 122 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_46207_818_1017_+ FIG00000279 45 7 45 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_46362_1_320_- FIG00077620 54 10 55 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_46390_1_197_+ FIG00000641 9 2 10 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_46429_829_1014_+ FIG00138171 42 6 42 Queuosine biosynthesis QueD, PTPS-I Zinc regulated enzymes 1 T2D_r2_46456_222_1014_- FIG00023943 201 30 201 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_r2_46460_1_1014_+ FIG00000056 239 38 239 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_r2_46503_1_606_- FIG00018865 15 7 17 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_46539_232_924_+ FIG00001237 56 12 58 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_r2_46602_361_1012_- FIG00001522 66 11 67 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_r2_46610_1_542_+ FIG00000312 15 5 16 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_r2_46789_215_1009_- FIG00017311 11 5 15 Capsular polysaccharide export system periplasmic protein KpsD Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_r2_46791_641_1009_+ FIG00007328 94 13 94 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_46795_360_929_- FIG00002161 8 4 12 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_r2_46811_209_412_- FIG00007828 26 6 26 Cold shock protein CspG Cold shock, CspA family of proteins 1 T2D_r2_46814_385_1009_+ FIG00024851 17 3 18 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_46875_273_1008_+ FIG00126843 81 15 84 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_47023_608_1006_- FIG00000962 45 11 46 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_47025_588_1006_+ FIG00138004 41 9 42 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_47047_1_161_+ FIG00451095 14 5 15 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_47055_1_423_+ FIG00000892 18 5 19 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_47144_611_1004_+ FIG00012746 67 11 68 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_47244_1_1003_+ FIG00030688 269 39 269 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_r2_47317_1_1002_+ FIG01306512 42 12 44 ATP-dependent protease La (EC 3.4.21.53) LonB Type I Proteasome bacterial 1 T2D_r2_47413_65_1001_+ FIG00132666 8 5 12 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_47443_1_706_+ FIG00106349 143 22 144 Putative N-acetylgalactosaminyl-diphosphoundecaprenol glucuronosyltransferase Teichuronic acid biosynthesis 9 T2D_r2_47601_1_335_+ FIG00000335 75 12 75 Twin-arginine translocation protein TatC Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_r2_47601_492_863_+ FIG00001182 98 14 98 [NiFe] hydrogenase nickel incorporation protein HypA NiFe hydrogenase maturation 1 T2D_r2_47601_866_999_+ FIG00001210 30 5 30 [NiFe] hydrogenase nickel incorporation-associated protein HypB NiFe hydrogenase maturation 1 T2D_r2_47637_243_788_- FIG00054478 147 22 147 Ribosomal-protein-L7p-serine acetyltransferase Ribosomal protein S5p acylation 1 T2D_r2_47709_703_998_+ FIG00011114 22 6 23 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_47757_1_242_- FIG00000355 27 6 28 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_47793_186_997_+ FIG01304636 28 10 29 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_r2_47833_1_821_+ FIG00000404 133 23 134 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_47900_1_400_- FIG00106663 10 4 15 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_47920_1_903_- FIG00002914 92 16 95 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_47923_778_995_+ FIG00006151 12 3 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_47951_644_995_+ FIG00013534 14 4 16 Substrate-specific component BL0695 of predicted ECF transporter ECF class transporters 345678 T2D_r2_47993_1_994_+ FIG00000113 104 24 107 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_48036_148_994_- FIG00000717 43 10 44 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_r2_48042_1_737_- FIG00034392 70 14 71 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_48127_1_593_+ FIG00016663 97 15 98 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_48206_1_495_- FIG00013525 10 3 13 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_r2_48217_1_991_- FIG00005992 11 6 15 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_48263_1_991_+ FIG00041038 77 21 78 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_48298_1_226_+ FIG00000260 58 9 58 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_48439_1_434_+ FIG00035701 109 17 109 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_r2_48439_443_988_+ FIG00002449 140 20 140 Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48) Exopolysaccharide Biosynthesis 1.0 T2D_r2_48441_169_756_- FIG00000601 91 17 93 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_48446_1_242_+ FIG00005547 7 4 9 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_r2_48446_272_730_+ FIG00000261 57 12 59 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_48519_1_715_+ FIG00041382 8 4 9 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_48534_607_987_- FIG00001175 33 6 36 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_48557_1_318_- FIG00000151 71 12 71 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_r2_48596_1_631_- FIG00001469 20 8 23 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_48654_1_986_- FIG00004172 251 38 252 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_48693_46_957_- FIG00000163 112 21 116 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_48744_1_578_+ FIG00016768 96 17 97 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_48752_1_720_+ FIG00013638 62 14 64 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_48774_1_910_+ FIG00016110 99 23 101 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_48868_381_983_- FIG00000532 93 16 95 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_48870_187_819_+ FIG00001067 8 3 10 Rubrerythrin Oxidative stress 1.2 T2D_r2_48892_1_933_+ FIG00028203 203 33 204 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_49149_1_479_- FIG00001449 121 19 121 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_r2_49205_164_978_- FIG01306479 15 7 17 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_49330_541_976_- FIG00000130 38 12 39 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_49332_1_976_+ FIG00000116 22 9 24 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_49360_1_317_- FIG00000001 12 4 13 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_49419_1_198_- FIG00134135 28 6 29 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_49448_75_755_+ FIG00055520 17 5 19 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_49496_1_783_+ FIG00025086 32 11 34 Xanthine permease Purine Utilization 1 T2D_r2_49556_1_283_- FIG00067562 4 2 6 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_49556_811_974_- FIG00140555 41 6 41 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_49636_130_972_+ FIG00000365 77 15 79 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_49674_458_972_+ FIG00004021 27 6 29 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_r2_49768_1_971_- FIG00001882 27 8 32 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_r2_49774_431_971_- FIG00093180 3 2 4 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_49823_192_818_- FIG00000997 90 18 113 Protein RtcB RNA 3'-terminal phosphate cyclase 2 T2D_r2_49836_256_933_+ FIG00007339 13 4 16 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_r2_49839_1_758_+ FIG00000990 141 19 141 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_49842_35_691_- FIG00080955 55 12 59 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_49901_1_311_- FIG00000434 25 8 26 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_49911_1_315_- FIG00010844 3 2 4 Flavodoxin Flavodoxin 1 T2D_r2_49940_272_895_- FIG00000013 139 24 140 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_49976_712_968_- FIG00229216 19 4 20 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_50060_1_582_+ FIG00036983 33 7 34 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_50090_1_967_- FIG00003757 12 7 15 L-arabinose transport ATP-binding protein AraG (TC 3.A.1.2.2) L-Arabinose utilization 1 T2D_r2_50126_427_699_- FIG00000189 75 11 75 LSU ribosomal protein L27p CBSS-176279.3.peg.868 1.x T2D_r2_50142_1_898_- FIG00005510 208 32 208 RND efflux system, outer membrane lipoprotein, NodT family Multidrug Resistance Efflux Pumps 1.12 T2D_r2_50148_27_383_- FIG00034293 27 5 28 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_50158_513_966_- FIG00000601 45 10 47 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_50207_1_965_- FIG00000372 23 5 26 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_50213_663_965_+ FIG00018369 9 4 10 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_50336_1_914_- FIG00000595 12 4 16 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_r2_50363_414_674_- FIG00006169 38 8 39 YoeB toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_r2_50363_677_963_- FIG00006338 28 7 30 YefM protein (antitoxin to YoeB) Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_r2_50493_1_907_+ FIG00005216 188 33 189 Sulfate permease Cysteine Biosynthesis 2.17 T2D_r2_50528_1_256_+ FIG00000990 13 4 14 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_50534_1_400_- FIG00000402 13 3 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_50548_654_961_- FIG00000065 58 10 59 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_50571_1_961_- FIG00051439 57 16 59 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_50606_1_155_- FIG00132617 3 2 3 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_50666_1_960_+ FIG00132839 142 25 144 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_50671_829_960_- FIG00013156 3 2 4 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_50719_216_959_- FIG00846773 12 5 14 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_50750_1_506_- FIG00000076 28 8 30 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_50750_800_959_- FIG00054459 10 3 11 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_50847_1_424_- FIG00001675 10 5 11 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_50972_1_882_- FIG00060517 39 11 41 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_50987_1_869_- FIG00000402 101 16 104 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_50991_97_956_- FIG00229257 234 33 234 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_r2_51101_1_317_+ FIG00000271 27 7 29 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_r2_51101_432_955_+ FIG00000223 78 13 80 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_r2_51126_1_954_- FIG00066643 22 7 25 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_51186_1_382_+ FIG00132801 19 5 20 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_r2_51186_507_953_+ FIG00000782 21 6 23 Exonuclease SbcD DNA repair, bacterial 3 T2D_r2_51199_572_953_- FIG00002541 34 8 36 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_51200_1_373_- FIG00001871 15 3 16 Glycerol-3-phosphate ABC transporter, permease protein UgpE (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_51267_455_952_- FIG00000191 70 12 71 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_51281_1_238_+ FIG00000102 14 5 20 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_51282_460_795_- FIG00000219 41 8 42 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_r2_51329_794_951_- FIG00000130 19 5 20 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_51331_430_951_+ FIG00000372 11 4 12 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_51338_1_345_+ FIG00021445 82 13 82 Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_51421_476_951_- FIG00000017 50 10 52 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_51437_1_950_+ FIG00140555 26 7 29 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_51508_79_950_+ FIG00008273 88 21 130 N-acetylneuraminate synthase (EC 2.5.1.56) Sialic Acid Metabolism 1.x T2D_r2_51511_1_351_+ FIG01297554 43 9 44 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_r2_51511_379_950_+ FIG00001354 43 10 44 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_r2_51583_28_405_- FIG00056617 3 2 6 PTS system, fructose- and mannose-inducible IIC component (EC 2.7.1.69) Fructose and Mannose Inducible PTS 2 T2D_r2_51583_576_949_+ FIG00000551 57 9 58 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_51691_1_631_- FIG00138208 116 19 117 Glycolate dehydrogenase (EC 1.1.99.14), subunit GlcD Glycolate, glyoxylate interconversions ? T2D_r2_51701_1_850_+ FIG00058830 63 16 65 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_51795_1_470_+ FIG00014849 16 3 18 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_r2_51795_475_831_+ FIG00135315 15 7 16 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_51821_211_636_+ FIG00000542 37 10 38 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_51868_1_361_+ FIG00028461 3 2 5 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_51868_426_945_+ FIG00000476 4 2 5 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_51869_1_740_- FIG00000163 41 11 43 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_51898_193_945_+ FIG00108342 102 19 103 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_51915_1_945_- FIG00093180 31 13 35 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_52037_1_569_+ FIG00001253 23 7 25 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_r2_52082_1_563_- FIG00000695 70 13 71 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_52136_1_135_+ FIG00018865 3 2 4 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_52186_246_407_- FIG00000126 13 3 14 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_52207_1_152_- FIG00044478 25 4 25 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_52219_1_235_+ FIG00132617 22 7 23 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_52238_1_153_- FIG00000243 32 6 32 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_52238_156_941_- FIG00046929 195 31 195 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_52295_1_432_+ FIG00004764 80 13 80 Ammonium transporter Ammonia assimilation 1 T2D_r2_52352_1_602_+ FIG00451095 162 24 162 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_52352_780_940_+ FIG00004788 34 6 34 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_r2_52377_800_939_+ FIG00000775 26 5 26 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_52562_276_937_- FIG00037273 67 13 72 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_r2_52571_1_937_+ FIG00018457 4 4 10 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_52601_1_315_- FIG00019415 7 3 8 Putative activity regulator of membrane protease YbbK CBSS-316057.3.peg.659 1 T2D_r2_52655_1_936_+ FIG00459778 254 36 258 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_52670_578_936_+ FIG00000476 6 2 7 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_52737_581_935_- FIG00126843 11 3 12 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_52763_1_513_+ FIG01956071 7 3 9 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_r2_52893_1_933_- FIG00010454 42 11 44 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_52916_38_933_- FIG00002332 97 19 99 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_r2_52945_630_932_+ FIG00009628 28 6 30 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_r2_52951_1_670_- FIG00000056 20 4 21 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_r2_53008_711_932_+ FIG00000303 17 5 20 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_r2_53028_434_859_+ FIG00080955 51 11 53 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_53073_194_931_+ FIG00129130 61 12 67 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_r2_53105_154_930_- FIG00146664 49 11 51 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_53381_1_514_+ FIG00000242 46 11 49 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_53405_1_316_- FIG00132586 56 10 57 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_r2_53490_1_516_- FIG00006092 142 20 142 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_53573_611_925_- FIG00133227 81 12 81 N-acetylneuraminate lyase (EC 4.1.3.3) Sialic Acid Metabolism 1.x T2D_r2_53620_1_924_+ FIG00000672 58 16 62 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_53621_210_924_- FIG00052802 176 26 177 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_r2_53647_1_924_- FIG00132839 165 27 166 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_53665_1_924_- FIG00001269 165 26 166 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_53669_1_856_+ FIG00000301 174 28 175 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_r2_53693_1_380_- FIG00001264 88 14 88 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_53778_1_401_+ FIG00005728 9 3 11 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_r2_53854_1_922_+ FIG00000356 59 13 64 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_53895_1_443_- FIG00001712 31 8 33 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_r2_53898_1_766_- FIG00024999 96 21 97 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Alkanesulfonate assimilation 9.? T2D_r2_53898_773_921_- FIG00515041 34 5 34 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Alkanesulfonate assimilation 9.? T2D_r2_53931_1_380_- FIG00006463 51 11 52 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_53938_83_532_+ FIG00023943 10 4 12 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_r2_53952_268_540_- FIG00026137 62 10 62 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_53952_606_921_- FIG00000132 26 4 27 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_54002_1_659_+ FIG00135469 32 10 34 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_r2_54018_1_920_- FIG00075970 71 18 72 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_54020_411_920_- FIG00001294 25 7 28 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_r2_54056_579_920_+ FIG00000368 55 11 56 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_r2_54130_1_248_+ FIG00005329 5 2 6 V-type ATP synthase subunit F (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_54150_1_573_+ FIG00000412 139 22 139 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_54214_1_918_+ FIG00073301 238 36 238 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_54271_1_262_- FIG00009194 18 4 19 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_54466_647_915_+ FIG00007694 12 3 13 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_r2_54516_514_849_+ FIG00000126 34 8 35 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_54543_526_915_+ FIG00000017 105 15 105 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_54627_1_914_+ FIG00004172 97 24 98 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_54687_1_913_+ FIG00000532 235 34 235 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_54724_718_913_- FIG00001642 6 2 7 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_54762_654_912_+ FIG00007328 60 10 60 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_54778_120_912_+ FIG01304601 160 25 161 Exonuclease SbcC DNA repair, bacterial 3 T2D_r2_54833_607_911_+ FIG00006151 45 8 45 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_54836_1_168_+ FIG00023004 7 3 9 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_54887_1_911_- FIG00000476 112 22 115 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_54906_132_911_+ FIG00001504 161 26 162 Serine--glyoxylate aminotransferase (EC 2.6.1.45) Serine-glyoxylate cycle 1 T2D_r2_54927_1_347_- FIG00009194 92 14 92 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_54965_745_910_- FIG00010759 5 2 6 Putative dihydroxyacetone kinase (EC 2.7.1.29), ADP-binding subunit Dihydroxyacetone kinases 3 T2D_r2_54998_1_127_+ FIG00047056 12 2 13 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_r2_55044_1_909_- FIG01260980 193 33 194 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_55106_460_909_+ FIG00001803 26 8 32 Polyferredoxin NapH (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_r2_55107_1_650_- FIG00052300 5 4 10 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_55198_1_368_+ FIG00010844 5 2 6 Flavodoxin Flavodoxin 1 T2D_r2_55215_204_614_+ FIG00000212 36 9 37 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_r2_55247_570_907_+ FIG01260980 19 6 21 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_55313_323_906_+ FIG00000056 110 18 111 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_r2_55325_314_906_+ FIG00000578 95 18 96 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_55345_1_495_- FIG00130344 40 10 45 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_55425_660_905_- FIG00000258 18 5 19 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_r2_55461_1_905_- FIG00001269 116 23 118 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_55546_1_449_+ FIG01260980 114 17 116 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_55580_100_903_- FIG00000402 52 14 54 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_55605_1_752_- FIG00000348 83 18 85 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_r2_55741_1_667_+ FIG00022300 139 22 140 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_55817_1_505_+ FIG00075702 36 9 37 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_55908_352_720_+ FIG00000557 11 4 13 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_r2_55958_1_371_- FIG00002273 44 9 45 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_r2_56021_1_890_+ FIG00000221 25 7 28 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_56090_447_898_+ FIG00014596 15 5 17 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_r2_56127_310_898_- FIG00133978 133 21 133 Ureidoglycolate dehydrogenase (EC 1.1.1.154) Allantoin Utilization X T2D_r2_56214_1_288_+ FIG00000111 17 6 18 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_56255_36_897_+ FIG00025216 48 14 51 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_56266_1_525_- FIG00016663 3 2 5 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_56331_542_896_+ FIG00058830 39 7 41 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_56367_1_568_+ FIG00000380 8 3 10 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_56405_190_895_+ FIG00070513 4 3 7 phosphotransbutyrylase (EC 2.3.1.19) Acetyl-CoA fermentation to Butyrate A T2D_r2_56466_144_467_+ FIG00148406 76 12 76 TTE0858 replicon stabilization protein (antitoxin to TTE0859) Toxin-antitoxin replicon stabilization systems 1 T2D_r2_56466_515_793_+ FIG01273570 77 10 77 TTE0859 replicon stabilization toxin Toxin-antitoxin replicon stabilization systems 1 T2D_r2_56524_203_757_+ FIG00058998 30 9 31 Vancomycin response regulator VanR Resistance to Vancomycin X T2D_r2_56545_68_646_- FIG00000573 89 16 90 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_56567_1_751_- FIG00010478 6 4 10 Phosphonate ABC transporter permease protein phnE2 (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_r2_56595_349_893_+ FIG00000118 129 21 129 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_r2_56665_554_892_+ FIG00002574 25 7 28 2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37) Phosphonate metabolism 1 T2D_r2_56721_1_688_+ FIG00041038 51 13 56 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_56754_1_423_+ FIG00024851 40 7 42 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_56756_1_445_- FIG00000163 22 6 24 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_56756_507_891_- FIG00001065 10 5 13 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_56767_253_768_+ FIG00001550 78 15 79 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_r2_56776_481_891_+ FIG00001022 19 7 22 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_56795_1_361_- FIG01260980 9 4 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_56830_751_891_+ FIG00000395 15 3 16 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_56845_66_890_+ FIG00034851 75 14 77 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_56850_1_890_+ FIG01260980 192 32 193 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_56894_492_890_- FIG00034392 30 8 33 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_56909_1_287_- FIG00026137 28 7 29 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_57001_450_889_- FIG00000540 13 6 15 Holo-[acyl-carrier protein] synthase (EC 2.7.8.7) CBSS-176299.4.peg.1292 3 T2D_r2_57089_1_246_- FIG00000377 59 8 59 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_57112_201_887_+ FIG00129616 112 20 113 GTP-binding protein EngA Universal GTPases 2 T2D_r2_57114_1_307_- FIG00000624 53 9 54 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_57124_303_752_+ FIG00000289 5 4 8 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_57150_1_609_- FIG00000397 21 9 23 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_r2_57207_1_159_+ FIG00000141 32 6 32 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_r2_57267_213_542_- FIG01273570 3 2 5 TTE0859 replicon stabilization toxin Toxin-antitoxin replicon stabilization systems 1 T2D_r2_57269_354_886_- FIG00001253 113 18 116 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_r2_57305_1_493_- FIG00000190 39 9 41 Recombination protein RecR DNA processing cluster 1.1 T2D_r2_57355_548_885_+ FIG00000017 24 7 25 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_57375_692_885_- FIG00089051 15 4 16 Small acid-soluble spore protein, beta-type SASP Small acid-soluble spore proteins 1 T2D_r2_57408_49_885_- FIG00002320 13 5 15 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_r2_57413_1_584_- FIG00002974 5 2 7 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_r2_57425_751_884_+ FIG00000531 9 3 10 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_57461_1_780_- FIG00451095 4 3 5 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_57563_1_160_+ FIG00133569 4 2 5 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_r2_57729_1_487_- FIG00138523 126 19 126 Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_r2_57735_695_881_- FIG00000147 18 4 19 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_57804_1_881_+ FIG00000422 70 16 75 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_57816_1_287_- FIG00000145 35 8 37 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_r2_57840_704_880_- FIG00000264 16 4 17 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_r2_57924_87_656_+ FIG00000103 17 4 18 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_58010_1_194_- FIG00001518 25 6 26 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_r2_58025_1_878_+ FIG00002470 244 35 244 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_58086_1_695_- FIG00023879 132 22 133 Anaerobic glycerol-3-phosphate dehydrogenase subunit B (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_58086_721_878_- FIG00001915 24 4 24 Anaerobic glycerol-3-phosphate dehydrogenase subunit A (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_58100_1_316_- FIG00058830 14 3 17 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_58136_1_444_- FIG00000877 89 15 90 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_58142_1_464_+ FIG00024401 8 2 10 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_58173_1_621_+ FIG00047056 14 5 16 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_r2_58230_438_740_+ FIG00005329 11 3 13 V-type ATP synthase subunit F (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_58230_745_876_+ FIG00001902 9 2 10 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_58261_58_522_+ FIG00000174 86 15 87 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_r2_58294_1_726_+ FIG00000283 129 21 130 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_58438_1_761_+ FIG00000494 17 6 20 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_58452_1_722_- FIG00022976 31 11 33 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_58506_155_873_+ FIG00000032 65 15 67 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_58567_666_872_- FIG00000494 12 3 13 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_58620_74_421_- FIG00092649 16 7 19 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_r2_58675_1_872_+ FIG00009564 4 4 7 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_r2_58709_1_152_- FIG00001548 10 2 11 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_58752_595_871_+ FIG00005243 11 3 12 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_58794_1_198_- FIG00021407 41 7 41 (R)-citramalate synthase (EC 2.3.1.182) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_58832_1_870_- FIG00000571 75 19 78 Signal transduction histidine kinase CheA (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_r2_58892_1_869_+ FIG00000392 131 25 132 Transcription termination factor Rho Transcription factors bacterial 1 T2D_r2_58908_65_862_+ FIG00869624 21 7 24 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_r2_58940_1_439_- FIG00010454 30 10 32 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_58960_196_869_+ FIG00004763 43 12 45 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_59075_615_868_+ FIG00001206 61 10 61 N-acetylglutamate synthase (EC 2.3.1.1) Arginine Biosynthesis extended 1.0 T2D_r2_59080_1_224_+ FIG00001578 43 7 43 Glycine cleavage system transcriptional antiactivator GcvR Orphan regulatory proteins 1 T2D_r2_59124_1_582_- FIG00000134 30 6 31 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_59124_613_867_+ FIG00001406 20 4 22 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_59134_1_550_+ FIG00001548 29 6 31 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_59151_1_480_+ FIG00000130 43 12 45 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_59153_81_867_- FIG00000280 121 22 122 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_59161_4_867_- FIG01304818 156 28 158 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_r2_59194_1_452_+ FIG00000380 18 5 19 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_59250_1_705_- FIG00016768 15 3 17 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_59260_108_866_- FIG00004764 166 29 166 Ammonium transporter Ammonia assimilation 1 T2D_r2_59268_1_631_- FIG00001134 150 23 150 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_r2_59283_280_866_- FIG00003495 17 4 19 Rhodanese-like domain protein Glutaredoxins 1 T2D_r2_59320_1_189_+ FIG00000145 6 2 7 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_r2_59363_445_696_+ FIG00000308 15 4 16 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_r2_59445_1_325_+ FIG00031250 13 5 14 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_59476_1_209_- FIG00000560 22 4 22 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_r2_59554_716_863_+ FIG00028461 17 4 18 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_59629_413_863_+ FIG00007514 21 8 22 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_59667_1_579_+ FIG00010600 3 2 7 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_r2_59700_259_862_- FIG00001577 56 13 62 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_r2_59707_82_862_+ FIG00000372 18 7 20 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_59792_28_861_+ FIG00031250 21 9 24 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_59804_1_861_- FIG00096593 220 33 220 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_59820_669_861_+ FIG00615494 43 7 43 DNA-binding protein HU DNA structural proteins, bacterial 1.1100 T2D_r2_59843_1_860_+ FIG00080231 75 15 77 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_r2_59904_1_593_- FIG01290653 97 20 98 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_59911_1_438_+ FIG00007941 24 4 25 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_r2_59996_1_319_- FIG00109688 10 3 11 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_r2_60036_1_176_+ FIG00010508 10 4 11 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_60036_208_859_+ FIG00018561 55 15 57 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_60071_1_561_+ FIG00000151 52 11 53 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_r2_60103_1_858_- FIG00048014 217 34 217 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_60117_238_813_+ FIG00010508 53 12 55 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_60133_1_705_+ FIG00000163 35 7 37 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_60175_1_304_- FIG00006151 12 5 29 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_60189_468_611_- FIG00000430 10 2 11 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_r2_60200_66_857_- FIG00000309 168 28 170 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_r2_60254_51_856_+ FIG00009194 20 6 24 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_60274_296_856_- FIG00003810 5 3 7 Arginase (EC 3.5.3.1) Arginine and Ornithine Degradation 1.34 T2D_r2_60280_1_400_- FIG00000191 93 15 93 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_60280_660_856_- FIG00037273 46 7 46 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_r2_60332_1_539_+ FIG00001406 67 12 68 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_60347_42_431_+ FIG00077620 7 3 8 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_60391_621_855_- FIG00019652 13 4 14 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_r2_60414_1_314_- FIG00032196 24 7 24 Formate hydrogenlyase transcriptional activator Formate hydrogenase 3.1?? T2D_r2_60442_326_855_+ FIG00005510 61 9 62 RND efflux system, outer membrane lipoprotein, NodT family Multidrug Resistance Efflux Pumps 1.12 T2D_r2_60449_348_855_- FIG00132770 35 8 37 Prephenate and/or arogenate dehydrogenase (unknown specificity) (EC 1.3.1.12)(EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_r2_60453_430_855_+ FIG00000116 13 5 15 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_60465_1_427_- FIG00000522 85 13 86 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_60465_647_855_+ FIG00003472 40 7 40 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_60556_1_455_- FIG00000283 50 11 53 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_60600_321_853_- FIG00002414 3 5 11 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_r2_60650_533_853_+ FIG00561498 18 4 22 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_60660_1_383_+ FIG00000372 30 8 32 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_60722_1_347_+ FIG00000365 57 11 59 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_60811_531_851_+ FIG00003439 36 7 37 Spore maturation protein A Spore Core Dehydration 1.1 T2D_r2_60909_312_818_- FIG00000159 9 6 11 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_r2_60945_1_269_- FIG00001676 14 3 15 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_60945_515_850_- FIG00025216 22 3 23 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_60986_1_850_- FIG00041038 25 12 27 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_60987_1_397_+ FIG00000822 35 9 37 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_r2_61021_565_849_+ FIG00014907 23 4 24 Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_61047_306_849_- FIG00000402 7 2 9 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_61068_30_849_- FIG00000001 15 7 17 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_61136_75_404_- FIG00108342 3 2 4 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_61147_1_372_+ FIG00005089 4 3 6 Spore cortex-lytic enzyme, lytic transglycosylase SleB Spore germination 1 T2D_r2_61162_1_229_+ FIG00000191 45 7 46 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_61190_1_248_+ FIG00003715 16 4 17 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_61192_1_848_- FIG00022300 176 28 177 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_61221_344_847_- FIG00000107 5 3 7 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_r2_61241_1_472_- FIG00128809 116 18 116 Heme biosynthesis protein related to NirL and NirH Heme biosynthesis orphans 3 T2D_r2_61258_257_682_+ FIG00000234 26 4 28 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_61299_299_847_- FIG00009682 29 8 31 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_61335_308_697_+ FIG00001166 54 9 55 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_61378_626_846_+ FIG00000412 12 4 13 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_61403_1_259_+ FIG00000459 15 4 17 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_61415_356_846_+ FIG00030029 23 4 24 3-demethylubiquinone-9 3-methyltransferase (EC 2.1.1.64) Ubiquinone Biosynthesis 2.x T2D_r2_61450_381_845_- FIG00001269 73 12 74 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_61478_1_506_+ FIG00009544 4 3 5 Late competence protein ComEA, DNA receptor Gram Positive Competence 3100 T2D_r2_61484_1_468_- FIG00023369 119 17 120 Chaperone protein DnaK Protein chaperones 2.0 T2D_r2_61516_94_845_- FIG00000437 26 10 28 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_61528_285_844_+ FIG00022300 43 11 45 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_61594_1_757_+ FIG00133515 183 27 184 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_61779_1_353_- FIG00013638 23 4 25 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_61791_1_376_+ FIG00000157 13 4 15 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_61802_547_842_+ FIG00000075 13 4 14 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_r2_61813_1_422_- FIG00000717 51 11 54 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_r2_61859_1_319_- FIG00028203 26 7 27 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_61868_37_216_- FIG00000409 25 5 26 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_r2_61882_188_841_- FIG00000402 30 9 32 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_61886_1_367_+ FIG00092649 17 4 18 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_r2_61910_1_363_+ FIG00000401 56 11 57 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_61910_365_841_+ FIG00002803 29 7 30 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_62005_1_425_- FIG00000269 110 17 110 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_r2_62012_1_840_- FIG00001311 230 32 230 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_r2_62077_576_839_- FIG00006551 32 8 33 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_62123_530_839_+ FIG00000463 25 6 27 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_62156_1_226_- FIG00019251 25 5 26 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_62186_15_344_+ FIG00006165 9 3 10 Uracil-DNA glycosylase, family 4 Uracil-DNA glycosylase 1 T2D_r2_62213_1_838_+ FIG00146664 95 19 97 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_62227_157_738_- FIG00000028 110 19 111 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r2_62281_1_838_+ FIG00561498 30 9 33 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_62305_14_837_- FIG01954244 5 3 7 putative polysialic acid transport protein Rhamnose containing glycans 4.1 T2D_r2_62421_314_836_+ FIG00001548 99 16 100 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_62511_1_444_- FIG00138468 70 12 71 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_62512_1_836_+ FIG00000011 36 9 37 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_62537_1_213_+ FIG00000200 20 5 21 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_r2_62613_443_835_+ FIG00004296 102 15 102 Amino acid-binding ACT Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_62623_1_416_- FIG00000721 78 12 79 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_62646_1_834_+ FIG00059426 38 11 41 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_r2_62662_607_834_- FIG00000209 56 9 56 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_62713_633_834_- FIG00000636 45 7 45 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_62766_1_268_+ FIG00042616 17 4 18 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_62766_471_761_+ FIG00021289 7 3 8 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_62792_517_833_+ FIG00007079 44 8 46 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_62833_507_833_+ FIG00003788 96 13 96 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_62837_1_201_+ FIG00006151 14 5 15 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_62874_1_568_- FIG00104848 7 3 9 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_62874_674_832_- FIG00011114 21 5 22 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_62891_1_595_- FIG00002560 152 24 152 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_62891_617_832_- FIG00067562 21 4 23 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_62912_557_832_+ FIG00020185 61 10 61 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_62919_1_687_+ FIG00036983 26 8 29 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_62962_1_832_- FIG00000404 195 32 197 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_62976_1_293_- FIG00000522 50 10 51 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_63100_1_362_- FIG00455853 11 4 12 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_63119_640_816_+ FIG00001798 9 2 10 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_r2_63147_1_830_+ FIG00000476 13 6 17 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_63148_1_150_- FIG00000131 17 3 18 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_63196_1_572_- FIG00001166 149 23 149 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_63229_1_797_+ FIG00002541 13 5 16 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_63231_1_575_+ FIG00000122 53 14 54 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_63481_1_827_+ FIG00001094 73 18 121 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_63527_1_530_- FIG00133515 59 13 61 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_63572_1_185_+ FIG00132617 10 4 11 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_63611_182_826_- FIG00000118 78 14 80 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_r2_63643_382_826_+ FIG01266244 60 12 61 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_63661_1_274_- FIG00000280 42 8 43 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_63692_1_360_- FIG00016663 6 4 9 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_63702_1_198_+ FIG00002914 4 2 5 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_63709_1_432_- FIG00007514 52 11 54 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_63899_570_824_+ FIG00132717 10 4 12 ATP-dependent protease La (EC 3.4.21.53) Type II Proteasome bacterial 1 T2D_r2_63924_1_823_+ FIG00060517 27 8 29 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_63935_92_823_+ FIG00000811 172 26 177 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_r2_63965_1_412_+ FIG00036224 102 16 102 Sialidase (EC 3.2.1.18) Sialic Acid Metabolism 1.x T2D_r2_63967_496_823_+ FIG00016110 7 3 9 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_63979_540_823_+ FIG00023946 41 8 42 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_64015_677_823_- FIG00000194 24 4 25 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_r2_64018_1_702_- FIG00000659 56 14 58 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_64025_1_823_+ FIG00001750 21 8 22 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_64086_1_822_+ FIG00010285 158 26 159 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_r2_64156_1_822_+ FIG00000176 108 20 110 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_64158_1_642_+ FIG00001803 156 24 156 Polyferredoxin NapH (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_r2_64186_576_821_- FIG00007495 8 3 9 Spore maturation protein B Spore Core Dehydration 1.1 T2D_r2_64188_466_821_+ FIG00000187 89 14 89 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_r2_64198_1_384_- FIG00000283 94 15 94 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_64280_350_821_+ FIG00000899 45 10 47 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_r2_64291_669_821_+ FIG00002914 23 5 23 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_64359_1_333_- FIG00000290 12 5 14 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_r2_64383_1_699_+ FIG00109688 173 25 174 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_r2_64416_1_740_- FIG00001054 72 16 73 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_64475_643_819_+ FIG00000445 23 4 24 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_r2_64490_385_819_- FIG00000782 5 2 6 Exonuclease SbcD DNA repair, bacterial 3 T2D_r2_64500_1_511_- FIG00129616 120 18 120 GTP-binding protein EngA Universal GTPases 2 T2D_r2_64504_1_563_+ FIG00067248 67 14 68 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_64525_1_819_- FIG00000356 114 22 116 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_64615_69_818_+ FIG00132994 21 6 23 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_64630_422_712_- FIG00000271 71 11 71 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_r2_64633_579_818_- FIG00018536 17 3 18 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_64640_1_818_- FIG00000824 33 12 36 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_r2_64642_1_489_+ FIG00006418 16 6 20 ABC transporter, predicted N-acetylneuraminate transport system permease protein 2 Sialic Acid Metabolism 1.x T2D_r2_64659_1_257_- FIG00007256 66 10 66 FIG139598: Potential ribosomal protein CBSS-176279.3.peg.868 1.x T2D_r2_64671_1_453_+ FIG01310319 13 3 15 Exoenzymes regulatory protein AepA in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_r2_64684_222_704_+ FIG00139491 5 3 9 NAD-reducing hydrogenase subunit HoxE (EC 1.12.1.2) Hydrogenases 2 T2D_r2_64689_208_817_+ FIG00002718 55 13 57 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_64691_1_817_+ FIG00085033 24 7 25 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_r2_64769_1_816_+ FIG00000308 135 24 137 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_r2_64771_1_816_+ FIG00001088 44 14 46 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_64780_231_816_- FIG00000343 159 24 159 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_64785_1_212_- FIG00000001 5 2 6 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_64785_261_816_+ FIG00066575 67 12 76 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_64786_1_336_+ FIG00000241 75 11 75 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_64875_1_362_+ FIG00041038 95 14 95 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_64875_374_815_+ FIG00000404 120 18 120 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_64910_1_358_- FIG00000402 14 4 15 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_64924_22_669_- FIG00000815 156 24 157 Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE Biogenesis of c-type cytochromes 1.1 T2D_r2_64956_1_815_+ FIG00041038 65 17 66 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_64974_1_815_+ FIG00021289 49 12 51 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_64977_1_790_+ FIG00018369 45 13 47 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_65058_1_506_- FIG00024851 33 10 35 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_65058_560_814_- FIG00013638 5 2 7 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_65103_1_639_+ FIG00000263 84 15 85 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_65162_439_813_- FIG00016514 51 8 53 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_65180_640_813_- FIG00000017 13 2 13 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_65211_1_312_+ FIG00006997 77 12 77 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_r2_65287_1_250_+ FIG00000899 28 6 29 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_r2_65304_1_211_+ FIG00134889 12 4 14 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_65309_1_335_- FIG00038814 80 13 80 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_r2_65343_1_812_+ FIG00006128 13 11 18 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_65396_1_763_+ FIG00006092 194 29 194 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_65413_1_811_- FIG00032178 7 6 12 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_65447_1_765_- FIG00000402 66 15 70 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_65448_1_491_- FIG00050603 3 3 5 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_65456_595_811_- FIG00055520 12 3 13 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_65460_300_557_- FIG00003307 10 5 11 FIG003307: hypothetical protein CBSS-323097.3.peg.2594 1 T2D_r2_65509_1_437_+ FIG00092649 12 3 13 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_r2_65520_1_810_+ FIG00000139 81 15 85 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_65539_584_810_+ FIG00001562 35 6 35 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_r2_65670_585_809_- FIG00000584 13 3 14 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_65735_14_808_- FIG00000329 94 16 95 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_65741_1_701_+ FIG00561498 3 2 5 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_65762_1_808_- FIG00085033 52 13 54 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_r2_65771_1_808_- FIG00126843 89 19 90 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_65801_1_225_+ FIG00452446 52 9 52 COG0028: Thiamine pyrophosphate-requiring enzymes Acetoin, butanediol metabolism 5 T2D_r2_65878_1_807_- FIG00061313 6 7 14 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_r2_65945_1_528_+ FIG00000241 76 15 77 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_65980_282_734_+ FIG00011659 68 11 69 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_r2_66013_1_439_+ FIG00021289 54 11 55 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_66066_1_806_- FIG00007941 37 13 39 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_r2_66073_113_580_+ FIG00000209 88 15 89 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_66133_1_328_+ FIG00085740 9 3 10 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_66144_1_632_+ FIG00074225 10 4 12 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_66144_639_805_+ FIG00086697 7 3 8 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_r2_66175_108_805_+ FIG00054888 128 21 128 CoB--CoM heterodisulfide reductase subunit D (EC 1.8.98.1) Anaerobic respiratory reductases 3 T2D_r2_66190_1_606_- FIG00006699 10 6 12 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_r2_66193_390_805_+ FIG00000578 11 3 14 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_66194_44_346_+ FIG00000477 9 3 10 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_66261_1_804_+ FIG00000111 99 21 137 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_66262_357_804_- FIG00138208 97 16 97 Glycolate dehydrogenase (EC 1.1.99.14), subunit GlcD Glycolate, glyoxylate interconversions ? T2D_r2_66267_138_804_- FIG00003472 57 15 60 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_66314_1_499_- FIG00104848 121 19 121 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_66333_1_803_- FIG00000069 10 6 12 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_66360_1_232_+ FIG00002049 62 9 62 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_66360_298_803_+ FIG00018865 67 12 67 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_66398_1_552_+ FIG00000288 20 4 22 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_r2_66470_1_264_+ FIG00016663 75 10 75 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_66531_1_462_- FIG01954097 19 8 21 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_66531_562_802_- FIG00006128 3 2 4 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_66542_449_801_+ FIG00001750 59 10 59 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_66551_1_773_+ FIG00000717 21 9 23 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_r2_66552_146_801_- FIG00000036 174 25 174 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_66558_457_801_- FIG00000182 83 13 83 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_r2_66653_480_800_- FIG00018457 8 2 9 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_66750_1_799_- FIG00000434 128 24 130 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_66788_1_799_- FIG00138258 34 11 36 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_66794_1_799_- FIG00000268 119 24 120 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_66795_1_791_+ FIG00016888 22 9 23 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_r2_66839_1_799_- FIG00000163 62 13 65 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_66869_451_799_+ FIG00038456 10 5 11 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_66876_1_753_+ FIG00000329 148 27 149 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_66877_1_549_+ FIG00004172 108 19 108 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_66884_1_255_- FIG00001824 39 8 42 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_66884_268_447_- FIG00125395 45 7 45 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_66888_1_146_+ FIG00000015 4 2 5 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_66910_1_798_- FIG00010454 11 7 14 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_66915_331_798_- FIG00000070 21 5 22 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_66918_1_390_- FIG00000088 21 7 23 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_66999_316_797_- FIG00002110 107 16 108 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_r2_67000_481_797_+ FIG00000131 51 9 52 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_67004_652_797_- FIG00000641 35 5 35 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_67056_257_797_+ FIG00229386 57 12 59 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_67147_206_796_+ FIG00000128 135 21 137 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_67188_1_796_+ FIG00059426 20 8 22 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_r2_67235_1_796_+ FIG00000085 210 30 210 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_67269_1_795_+ FIG00018561 103 22 106 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_67306_660_795_- FIG00000441 11 2 12 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_67314_336_795_+ FIG00001170 4 5 12 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_r2_67349_151_699_+ FIG00008304 57 10 62 Aspartate 1-decarboxylase (EC 4.1.1.11) Coenzyme A Biosynthesis A.191 T2D_r2_67372_1_794_+ FIG00000147 140 24 141 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_67418_301_794_+ FIG00000036 95 17 96 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_67444_312_794_+ FIG00046358 112 18 112 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_67456_609_794_- FIG00000440 17 3 18 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_r2_67458_287_794_+ FIG00000365 118 17 119 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_67466_117_794_- FIG00005237 113 19 115 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_r2_67478_1_453_+ FIG00011468 95 16 96 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_r2_67582_439_793_+ FIG00623809 45 8 46 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_67647_1_792_+ FIG00005727 104 19 106 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_67666_520_792_- FIG00000323 23 5 24 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_67679_182_792_+ FIG00007514 10 5 16 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_67737_1_662_- FIG00001065 40 11 42 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_67873_1_790_- FIG00001869 23 7 27 Exoribonuclease II (EC 3.1.13.1) RNA processing and degradation, bacterial 1 T2D_r2_67875_221_790_- FIG00007714 3 3 8 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_r2_67932_1_289_- FIG00000441 65 9 66 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_67932_590_790_- FIG00000108 39 7 40 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_67940_1_447_- FIG00000221 7 4 9 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_67940_448_790_- FIG00024401 12 4 14 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_68002_323_789_+ FIG00031250 80 15 80 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_68007_1_353_- FIG00000145 5 2 7 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_r2_68009_320_789_+ FIG00026137 73 13 74 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_68087_1_789_+ FIG00001209 58 14 60 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_68088_1_408_- FIG00000348 97 14 98 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_r2_68251_1_740_- FIG00003195 170 27 170 L-idonate 5-dehydrogenase (EC 1.1.1.264) D-gluconate and ketogluconates metabolism 1.3 T2D_r2_68283_425_787_- FIG00000445 23 7 24 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_r2_68296_542_787_+ FIG00001550 21 6 22 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_r2_68316_1_628_- FIG00000287 12 5 14 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_68317_1_721_- FIG00083946 58 14 59 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_68360_1_786_- FIG00000038 91 19 92 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_68366_1_425_- FIG00108342 105 17 105 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_68368_1_328_- FIG00029322 8 4 9 Aerobic C4-dicarboxylate transporter for fumarate, L-malate, D-malate, succunate Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_68414_1_141_- FIG00018396 36 5 36 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_68414_183_575_- FIG01955919 58 10 60 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_68443_15_785_- FIG00018392 16 4 17 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_r2_68451_1_785_- FIG00000863 6 4 8 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_r2_68489_157_785_+ FIG00133005 173 25 173 Lysophospholipase L2 (EC 3.1.1.5) Triacylglycerol metabolism 7 T2D_r2_68494_1_504_+ FIG00136922 128 19 129 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_68494_563_785_+ FIG00026006 45 8 45 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_68496_366_785_+ FIG00035701 12 6 14 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_r2_68510_354_785_- FIG00132630 25 8 26 Ferric uptake regulation protein FUR Oxidative stress 1.2 T2D_r2_68582_638_784_- FIG00005022 3 2 4 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_68657_159_784_- FIG00000494 6 4 7 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_68679_1_133_- FIG00000139 8 2 8 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_68681_1_783_- FIG00136922 213 31 213 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_68686_256_783_- FIG01307086 78 14 78 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_r2_68710_1_707_- FIG00006032 33 8 34 Cobalamin synthase Cobalamin synthesis 2 T2D_r2_68727_1_783_+ FIG00000241 112 21 113 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_68745_1_783_+ FIG00000793 219 32 219 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_68757_1_392_- FIG00002541 4 3 5 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_68826_1_543_+ FIG00136692 141 21 141 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_68828_306_782_- FIG00013347 101 16 101 Stage II sporulation protein related to metaloproteases (SpoIIQ) Sporulation-related Hypotheticals 2.x T2D_r2_68875_60_782_- FIG00074196 27 8 29 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_68932_1_781_+ FIG00007941 141 23 141 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_r2_68958_1_193_+ FIG00008507 12 4 14 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_r2_68975_391_781_+ FIG00521220 20 5 21 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_r2_68992_1_781_- FIG01959876 173 28 173 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_69040_452_780_+ FIG00004410 29 6 40 Aspartate racemase (EC 5.1.1.13) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_69046_1_659_- FIG00067681 20 4 21 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_69065_1_780_+ FIG00000140 11 2 13 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_69155_1_779_- FIG00000303 60 15 71 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_r2_69159_1_779_- FIG00001129 24 7 26 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_r2_69164_232_543_- FIG00000276 25 8 26 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_r2_69173_1_344_- FIG00000200 34 9 37 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_r2_69191_1_570_- FIG00011537 41 10 43 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_69202_1_406_- FIG00000308 50 9 51 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_r2_69222_162_779_+ FIG00598409 12 6 15 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_r2_69308_1_778_+ FIG00001712 67 16 68 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_r2_69309_96_608_+ FIG00000892 59 12 60 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_69315_1_269_+ FIG00096593 64 10 64 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_69315_272_778_+ FIG00000390 108 19 108 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_69333_1_559_+ FIG00034392 135 21 135 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_69350_1_440_- FIG00002020 9 3 10 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_69392_1_642_- FIG00021445 48 8 52 Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_69411_1_434_+ FIG00010844 69 14 70 Flavodoxin Flavodoxin 1 T2D_r2_69420_1_777_- FIG01260980 19 7 20 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_69429_415_777_- FIG00052605 41 9 42 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_69473_479_777_- FIG00001292 17 4 19 D-alanine aminotransferase (EC 2.6.1.21) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_69527_1_776_- FIG00018457 6 3 9 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_69529_179_776_- FIG01954097 38 11 39 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_69570_1_776_- FIG00000134 138 26 140 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_69630_1_386_+ FIG00004170 16 4 17 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_r2_69670_1_775_+ FIG00001547 18 6 20 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_69671_360_775_+ FIG00000441 4 2 5 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_69733_1_775_+ FIG00135554 30 8 33 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_r2_69756_497_774_- FIG00001642 66 11 66 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_69773_1_774_- FIG01266244 158 26 160 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_69826_1_774_- FIG00001547 8 3 9 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_69837_1_774_- FIG00032196 170 27 170 Formate hydrogenlyase transcriptional activator Formate hydrogenase 3.1?? T2D_r2_69850_345_774_- FIG00000434 100 16 100 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_69902_118_714_- FIG00003484 9 3 11 Lactaldehyde reductase (EC 1.1.1.77) L-rhamnose utilization 1 T2D_r2_69930_1_773_+ FIG00019251 13 5 15 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_69938_1_409_- FIG00000441 10 3 13 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_69946_1_257_- FIG00000069 5 3 6 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_69962_414_773_+ FIG01271998 20 5 22 Possible hypoxanthine oxidase XdhD (EC 1.-.-.-) Purine conversions 4.1118100 T2D_r2_69973_453_773_- FIG00081580 5 2 6 Arsenic efflux pump protein Arsenic resistance 1 T2D_r2_69988_494_682_+ FIG00007960 3 2 4 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_70006_1_772_- FIG00075970 16 5 18 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_70036_1_445_- FIG00006997 56 10 58 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_r2_70112_1_752_- FIG00001642 43 10 44 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_70219_8_771_- FIG00001022 117 21 119 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_70244_139_771_- FIG00066575 7 3 9 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_70284_1_770_- FIG00024401 18 5 22 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_70287_1_770_+ FIG00000069 54 16 55 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_70323_73_770_+ FIG00001635 49 14 51 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_70332_58_597_- FIG00000151 54 11 55 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_r2_70341_485_770_- FIG00013638 25 7 27 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_70342_150_770_+ FIG00000207 59 13 62 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_70379_1_770_+ FIG00000147 122 22 124 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_70435_642_769_+ FIG00001528 5 2 6 Cobalt-precorrin-3b C17-methyltransferase Cobalamin synthesis 2 T2D_r2_70531_292_768_- FIG00013156 4 3 6 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_70569_519_768_- FIG00001824 9 4 10 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_70585_104_574_- FIG00000209 69 16 70 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_70590_290_768_+ FIG00026137 73 13 75 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_70657_1_378_- FIG00132666 95 14 95 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_70665_1_350_+ FIG00024401 16 3 18 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_70683_444_767_+ FIG00000641 26 7 27 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_70751_375_767_- FIG00000298 15 4 16 GTP-binding protein EngB Universal GTPases 2 T2D_r2_70799_449_766_- FIG00137824 19 5 20 Iron compound ABC uptake transporter substrate-binding protein PiuA Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_70801_1_766_- FIG00000176 34 13 64 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_70826_269_766_+ FIG00005111 11 3 14 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_r2_70885_339_766_+ FIG00073301 12 4 13 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_70904_558_766_+ FIG00000102 7 3 9 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_70928_449_766_+ FIG00000328 8 2 10 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_r2_70973_1_765_- FIG00058830 43 12 45 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_70998_1_169_- FIG00000624 31 6 32 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_71022_1_765_- FIG01304860 181 29 181 [Ni/Fe] hydrogenase, group 1, small subunit Hydrogenases 2 T2D_r2_71043_475_765_- FIG00059211 3 3 4 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_71064_1_765_- FIG00008273 182 29 182 N-acetylneuraminate synthase (EC 2.5.1.56) Sialic Acid Metabolism 1.x T2D_r2_71079_59_765_- FIG00000962 180 26 181 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_71086_1_305_- FIG00133292 4 3 6 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_71088_338_764_+ FIG00000395 45 8 46 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_71156_321_764_+ FIG00023369 97 15 97 Chaperone protein DnaK Protein chaperones 2.0 T2D_r2_71161_481_764_+ FIG00005529 64 11 64 Nitrate/nitrite transporter Nitrate and nitrite ammonification 1 T2D_r2_71202_355_764_+ FIG00010508 32 9 35 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_71280_118_456_- FIG00005111 92 13 92 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_r2_71280_469_763_- FIG00004764 67 11 67 Ammonium transporter Ammonia assimilation 1 T2D_r2_71282_1_508_+ FIG00001306 24 6 26 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_r2_71333_1_447_- FIG00000013 4 4 5 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_71336_153_446_+ FIG00138004 27 5 28 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_71480_1_761_+ FIG00001712 74 16 75 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_r2_71489_1_605_+ FIG00001065 131 20 132 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_71542_1_761_+ FIG00000116 73 16 75 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_71543_1_651_- FIG00000157 160 24 160 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_71576_271_761_+ FIG00048580 16 3 17 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_r2_71591_341_760_- FIG00131476 26 5 27 RecD-like DNA helicase Atu2026 DNA repair, bacterial RecBCD pathway 3 T2D_r2_71615_614_760_+ FIG00010285 12 3 13 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_r2_71619_1_760_+ FIG00000911 77 12 79 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_71644_1_760_+ FIG00006117 182 28 182 Agmatine/putrescine antiporter, associated with agmatine catabolism Polyamine Metabolism 2 T2D_r2_71648_287_760_+ FIG00945384 23 6 25 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_71673_1_671_+ FIG00003406 79 17 81 AmpG permease Recycling of Peptidoglycan Amino Acids 1 T2D_r2_71682_388_760_- FIG00122145 88 14 88 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_71717_496_759_- FIG00108342 29 9 30 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_71772_19_759_- FIG00051439 49 15 51 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_71840_357_758_- FIG00003715 86 14 86 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_71896_1_647_- FIG00093180 15 4 16 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_71938_1_501_+ FIG00000482 46 11 47 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_71951_1_758_+ FIG00080231 92 18 94 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_r2_71987_1_758_- FIG00001166 6 4 8 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_72041_1_680_+ FIG00067248 160 25 160 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_72042_1_757_+ FIG00022899 38 16 40 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_72100_346_757_+ FIG00022899 17 4 18 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_72136_237_757_- FIG00000187 35 11 36 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_r2_72188_1_756_+ FIG00000280 150 26 168 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_72212_609_756_+ FIG00022899 20 4 21 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_72248_1_756_+ FIG00000001 9 10 28 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_72257_528_756_+ FIG00042627 53 8 53 Magnesium and cobalt efflux protein CorC Copper homeostasis: copper tolerance 3 T2D_r2_72288_416_756_+ FIG01306479 11 5 14 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_72319_1_527_- FIG00000156 144 21 144 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_72320_1_572_- FIG00002920 48 10 49 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_r2_72373_1_755_- FIG00018699 5 5 7 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_72376_21_668_- FIG00003555 30 9 31 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_72400_280_573_- FIG00000095 6 2 9 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_72400_615_755_- FIG00026918 8 2 9 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_72421_580_755_+ FIG00001449 24 6 25 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_r2_72437_1_755_+ FIG00004078 16 5 18 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_72548_1_208_+ FIG00000287 6 3 7 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_72588_489_753_+ FIG00000244 57 9 57 Ketol-acid reductoisomerase (EC 1.1.1.86) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_72591_1_753_+ FIG00034851 174 29 176 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_72613_342_753_- FIG00763261 10 4 11 DNA replication protein DnaC DNA-replication 4 T2D_r2_72681_1_558_+ FIG01266244 113 19 114 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_72723_1_752_- FIG00055715 98 20 99 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_72747_158_752_+ FIG00000132 145 22 145 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_72788_331_669_+ FIG00091606 85 13 85 Methionine synthase activation domain (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_72825_52_752_- FIG00000897 8 5 12 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_r2_72837_432_751_+ FIG00058830 11 4 13 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_72851_1_280_+ FIG00002968 15 3 18 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_r2_72888_1_588_+ FIG00007373 16 4 18 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_r2_72893_474_751_- FIG00000720 43 8 44 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_r2_72912_429_751_- FIG00229257 87 12 87 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_r2_72915_1_492_- FIG00132586 7 2 9 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_r2_72915_495_751_- FIG00022568 8 3 9 Phosphonate ABC transporter ATP-binding protein (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_r2_72924_411_716_+ FIG00000578 54 10 56 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_72926_1_470_- FIG01304818 16 4 18 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_r2_72927_266_751_+ FIG00000017 31 9 32 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_73016_478_660_+ FIG00000409 42 7 42 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_r2_73018_227_750_- FIG00000315 129 20 130 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_r2_73076_77_750_+ FIG00006551 133 22 133 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_73092_241_621_- FIG00062547 37 10 38 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_r2_73096_1_697_+ FIG00007881 154 23 155 Cytochrome c551 peroxidase (EC 1.11.1.5) Protection from Reactive Oxygen Species 1 T2D_r2_73131_1_719_- FIG00000268 176 28 177 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_73180_1_749_- FIG00229386 91 20 93 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_73185_288_749_+ FIG00007073 21 6 23 Exopolysaccharide biosynthesis glycosyltransferase EpsF (EC 2.4.1.-) Exopolysaccharide Biosynthesis 1.0 T2D_r2_73191_74_670_- FIG00009156 45 11 48 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_r2_73196_1_425_- FIG00034293 47 12 48 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_73232_1_146_- FIG00000555 16 3 17 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_73251_565_748_- FIG00001105 31 5 31 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_r2_73265_1_748_- FIG00022300 223 30 223 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_73268_1_244_+ FIG00000323 5 2 7 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_73290_1_323_- FIG00059211 25 5 26 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_73314_1_748_- FIG00085740 37 9 39 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_73318_1_481_+ FIG00013638 19 6 21 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_73336_509_748_- FIG00138209 33 5 33 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_73368_1_560_+ FIG00016768 113 20 114 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_73368_597_747_+ FIG00000614 38 6 38 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_r2_73380_1_490_+ FIG00022300 62 12 63 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_73398_63_747_+ FIG00057709 165 24 165 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_73462_590_747_+ FIG00074225 5 3 6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_73483_1_747_- FIG00093180 21 4 22 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_73491_133_492_+ FIG00008572 38 10 40 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_r2_73507_1_428_- FIG00010134 15 4 17 Methionine transporter MetT Methionine Degradation 3 T2D_r2_73507_449_643_- FIG00084255 23 4 24 Stage III sporulation protein AC Sporulation Cluster III A 1.x T2D_r2_73554_1_218_- FIG00013638 46 8 46 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_73575_67_414_- FIG01280345 77 12 78 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_r2_73604_191_746_- FIG00000552 30 8 32 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_r2_73621_4_510_- FIG00001555 114 17 114 Cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Putative oxidase COG2907 9 T2D_r2_73646_1_343_+ FIG00018699 13 3 15 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_73690_1_745_- FIG00000877 108 21 109 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_73741_1_252_- FIG00013994 12 3 14 Short chain fatty acids transporter Polyhydroxybutyrate metabolism 5.6 T2D_r2_73750_504_745_- FIG00022300 68 9 68 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_73812_1_745_+ FIG00000672 145 23 146 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_73848_539_744_+ FIG00000184 50 8 50 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_73850_210_581_- FIG00000047 20 4 22 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_73885_588_744_+ FIG00521176 10 4 11 fructose response regulator of fruA and EII fructose/mannose Fructose and Mannose Inducible PTS 2 T2D_r2_73897_1_680_- FIG00000352 94 18 96 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r2_73932_1_744_+ FIG00000494 13 6 15 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_73970_1_668_+ FIG00041382 189 27 189 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_73985_257_743_- FIG00000209 69 14 70 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_74004_1_252_- FIG00000200 30 6 31 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_r2_74004_276_743_- FIG00001577 57 13 58 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_r2_74008_124_441_- FIG01955919 78 12 79 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_74011_217_743_+ FIG00088533 7 4 12 Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Cobalamin synthesis 2 T2D_r2_74027_1_743_- FIG00011537 133 22 134 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_74045_1_743_+ FIG00003751 76 17 78 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_r2_74082_522_743_+ FIG00229386 17 4 18 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_74102_1_743_- FIG00001269 105 21 106 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_74128_1_742_- FIG00002914 46 8 51 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_74152_1_390_- FIG00009775 27 8 28 Glycosyl transferase, group 1 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_74168_1_742_+ FIG00130344 65 15 67 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_74179_78_563_- FIG00000892 51 10 54 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_74180_1_742_+ FIG00000038 59 14 60 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_74205_1_143_- FIG00001675 13 3 14 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_74279_342_741_- FIG00000695 10 5 11 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_74300_1_741_- FIG00006128 49 12 51 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_74327_1_356_+ FIG00000076 22 7 24 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_74327_434_741_+ FIG00000624 28 5 29 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_74477_73_740_+ FIG00229257 8 3 10 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_r2_74478_444_740_+ FIG01954097 9 3 11 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_74490_1_740_+ FIG01304892 52 12 56 Betaine aldehyde dehydrogenase (EC 1.2.1.8) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_74513_1_740_+ FIG00046929 9 5 16 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_74559_1_739_+ FIG00024930 52 11 54 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_74565_1_739_+ FIG00000812 44 11 46 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_r2_74639_424_738_+ FIG00002194 29 6 30 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_r2_74648_1_237_+ FIG00001020 53 9 53 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_74648_381_738_+ FIG00000477 17 5 19 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_74727_234_647_- FIG01255877 53 11 54 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_r2_74856_364_737_+ FIG00003460 90 14 90 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_74864_1_737_+ FIG00000268 199 29 200 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_74906_136_737_- FIG00000721 73 15 75 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_74936_1_504_- FIG00006953 21 4 23 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_r2_74967_1_736_- FIG00000395 68 14 69 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_74987_1_736_+ FIG00036983 32 9 35 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_75042_1_736_- FIG00002742 17 6 19 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_75060_1_735_+ FIG00000504 186 29 186 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_75237_1_734_+ FIG00000422 192 29 193 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_75247_1_734_+ FIG00042267 46 11 48 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_r2_75343_450_734_- FIG00000017 45 8 47 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_75386_1_733_- FIG00007041 46 14 48 Chemotaxis protein CheV (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_r2_75404_1_241_- FIG00006151 27 6 29 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_75420_1_733_+ FIG00001094 166 28 166 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_75431_1_498_+ FIG00001818 64 13 65 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_r2_75505_1_732_- FIG00561498 47 11 49 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_75524_56_661_- FIG00000973 6 5 8 RNA polymerase sigma factor RpoE Transcription initiation, bacterial sigma factors 1 T2D_r2_75591_470_732_+ FIG00002332 7 3 8 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_r2_75666_470_731_+ FIG00047509 8 3 10 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_75704_212_731_+ FIG00134135 114 18 114 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_75722_59_253_- FIG00138313 40 7 40 Twin-arginine translocation protein TatA Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_r2_75745_1_731_- FIG00079740 4 4 6 Xyloside transporter XynT Xylose utilization 1 T2D_r2_75749_1_731_+ FIG00000351 28 8 30 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_r2_75753_1_240_- FIG00009265 28 7 29 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) Selenocysteine metabolism 1.1 T2D_r2_75761_1_291_+ FIG00013638 11 4 12 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_75767_1_731_+ FIG00000032 187 29 188 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_75808_1_730_- FIG00137374 198 29 199 ATP-dependent DNA helicase SCO5184 DNA repair, bacterial RecBCD pathway 3 T2D_r2_75820_384_730_+ FIG00459778 41 8 43 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_75861_191_730_+ FIG01304860 115 20 115 [Ni/Fe] hydrogenase, group 1, small subunit Hydrogenases 2 T2D_r2_75916_392_730_+ FIG00000621 53 10 54 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_75933_1_729_- FIG00018457 14 5 16 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_75936_260_541_+ FIG00015476 44 7 45 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_r2_75987_1_729_+ FIG00006128 63 12 66 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_76065_1_490_- FIG00001306 80 15 82 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_r2_76066_372_728_- FIG00001377 28 6 29 Pyruvate oxidase [ubiquinone, cytochrome] (EC 1.2.2.2) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_76092_1_234_+ FIG00000263 8 3 9 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_76092_285_530_+ FIG00000271 21 5 22 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_r2_76092_555_728_+ FIG00000223 15 4 16 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_r2_76102_100_728_+ FIG00000446 21 9 23 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_76263_1_727_+ FIG00136193 33 11 36 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_r2_76310_1_727_+ FIG00002718 23 10 25 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_76344_385_727_+ FIG00000025 4 2 5 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_76356_1_298_- FIG00000402 11 4 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_76395_1_222_+ FIG00026137 14 4 15 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_76400_1_726_+ FIG00561498 85 15 88 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_76468_1_726_- FIG01304601 6 3 8 Exonuclease SbcC DNA repair, bacterial 3 T2D_r2_76478_1_726_- FIG00083946 157 26 157 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_76557_1_725_- FIG00018699 202 28 202 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_76562_78_644_+ FIG00009156 15 5 17 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_r2_76586_1_501_+ FIG00000695 21 5 23 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_76623_1_725_- FIG00089870 74 15 75 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_r2_76650_388_725_+ FIG00085033 19 5 21 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_r2_76701_202_725_+ FIG00000132 56 14 58 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_76712_1_724_+ FIG00038343 10 4 13 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_r2_76737_1_724_+ FIG00132617 168 26 169 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_76794_1_724_+ FIG01260980 212 29 212 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_76796_530_724_+ FIG00000088 47 7 47 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_76859_579_724_+ FIG00000433 27 5 27 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_76959_1_254_- FIG00031250 28 6 29 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_76988_150_380_+ FIG00000551 46 8 46 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_77004_1_268_+ FIG00000148 21 5 22 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_r2_77029_1_722_- FIG00026918 22 8 23 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_77041_1_722_+ FIG00000185 34 9 36 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_77055_455_722_+ FIG00001960 60 9 60 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_r2_77162_45_722_- FIG00000838 13 4 16 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_77187_1_721_- FIG00000001 46 15 47 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_77259_251_511_+ FIG00001133 5 3 7 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_r2_77307_1_721_- FIG00063189 100 21 102 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_r2_77323_92_721_- FIG00133219 7 3 8 Thiamin biosynthesis lipoprotein ApbE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_77376_1_720_- FIG00018699 27 7 28 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_77392_1_720_+ FIG00000476 31 7 32 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_77405_86_658_- FIG00000028 20 8 21 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r2_77424_379_720_+ FIG00009544 8 3 9 Late competence protein ComEA, DNA receptor Gram Positive Competence 3100 T2D_r2_77431_509_720_- FIG00001384 31 5 32 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_77455_273_701_+ FIG00000188 18 5 19 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_r2_77501_1_719_+ FIG00132617 53 13 55 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_77508_1_719_- FIG00000990 156 26 158 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_77519_1_719_+ FIG00196963 200 29 200 Two-component sensor kinase, associated with ferric iron transporter, SPy1061 homolog Iron acquisition in Streptococcus 1 T2D_r2_77544_402_719_+ FIG00006764 10 3 11 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_r2_77562_1_719_- FIG00016303 10 3 12 Hyaluronan synthase (EC 2.4.1.212) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_77570_157_719_+ FIG00018396 135 21 135 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_77581_426_719_- FIG00003955 70 11 70 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_r2_77584_412_719_+ FIG00001635 16 5 19 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_77610_1_719_+ FIG00024401 12 4 15 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_77627_1_719_+ FIG00000283 179 28 179 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_77654_1_596_+ FIG00001385 123 21 123 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_77678_1_422_- FIG00064110 6 2 8 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_77694_589_718_+ FIG00002695 28 4 28 Biosynthetic arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_77739_1_409_+ FIG00001062 72 11 73 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_r2_77840_1_368_+ FIG00000025 8 3 9 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_77871_139_717_- FIG00000380 87 15 88 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_77919_1_194_+ FIG00001132 25 5 26 LSU ribosomal protein L16p (L10e) Ribosome LSU bacterial 9 T2D_r2_77919_410_717_+ FIG00000202 26 6 30 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_78042_1_384_- FIG00000350 39 7 40 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_78059_1_716_+ FIG00001168 8 9 23 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_78063_511_716_- FIG00000177 34 6 34 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_r2_78104_1_621_- FIG00002273 8 2 9 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_r2_78107_1_715_+ FIG00000343 55 13 57 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_78109_271_639_- FIG00000036 26 5 27 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_78135_457_715_- FIG01955902 9 2 10 Rubredoxin Rubrerythrin 2 T2D_r2_78171_1_267_+ FIG00001280 46 8 46 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_r2_78171_457_715_+ FIG00008708 63 10 63 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_r2_78180_1_715_- FIG01260980 15 8 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_78187_140_610_- FIG00000555 7 3 9 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_78229_1_528_+ FIG00000824 101 19 102 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_r2_78229_552_715_+ FIG00018865 17 4 18 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_78369_102_714_- FIG00093180 168 24 168 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_78436_159_713_+ FIG00007941 31 6 33 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_r2_78501_1_277_- FIG00077620 10 4 11 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_78501_335_713_- FIG00000659 5 3 7 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_78529_1_494_+ FIG00006128 143 20 143 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_78529_553_713_+ FIG00945384 24 6 24 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_78545_1_713_+ FIG00000476 44 13 49 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_78573_288_712_+ FIG00001824 28 6 30 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_78584_1_472_+ FIG00000103 96 15 98 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_78588_1_342_- FIG00050603 37 8 39 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_78611_1_327_+ FIG00000840 11 4 12 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_r2_78648_1_712_+ FIG00083946 115 24 116 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_78712_429_712_+ FIG00002412 16 3 18 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_r2_78723_1_711_+ FIG00000317 15 4 17 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_78813_1_264_- FIG00010600 16 6 18 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_r2_78846_1_711_- FIG00000114 146 23 147 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_78848_1_477_+ FIG00003955 74 13 75 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_r2_78871_1_320_- FIG00000011 9 5 11 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_78953_1_260_- FIG00000395 24 5 25 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_78955_1_588_+ FIG01290653 13 6 14 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_78958_1_592_- FIG00095288 5 2 6 Cell wall endopeptidase, family M23/M37 Glutaredoxins 1 T2D_r2_78966_49_710_+ FIG00000437 18 6 20 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_78986_1_334_+ FIG00057709 85 13 85 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_79140_1_249_+ FIG00006542 17 4 18 FIG006542: Phosphoesterase CBSS-257314.1.peg.676 4.x T2D_r2_79140_297_638_+ FIG01303866 3 2 4 DNA repair exonuclease family protein YhaO DNA repair, bacterial 3 T2D_r2_79164_1_340_+ FIG00000368 101 14 101 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_r2_79185_1_141_+ FIG00092649 10 3 11 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_r2_79185_153_365_+ FIG00004843 15 4 16 Protein YidD Cell Division Subsystem including YidCD 1 T2D_r2_79193_1_708_- FIG00034851 106 21 106 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_79228_430_708_+ FIG00002300 25 5 26 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_r2_79259_1_708_+ FIG00011537 130 23 131 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_79323_1_708_- FIG00001548 14 3 16 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_79329_1_576_+ FIG00025216 33 10 62 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_79330_1_312_+ FIG00000276 78 12 78 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_r2_79332_89_708_- FIG00059211 153 23 154 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_79353_1_462_+ FIG00001635 29 10 51 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_79357_1_464_- FIG01304601 100 16 101 Exonuclease SbcC DNA repair, bacterial 3 T2D_r2_79378_419_707_- FIG00018457 4 2 5 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_79384_1_707_- FIG00000402 35 12 37 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_79390_1_433_+ FIG00034392 55 12 56 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_79508_16_707_+ FIG00021644 176 27 176 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_79531_214_706_+ FIG00003997 113 18 113 Protein with similarity to RtcB Translation termination factors bacterial 1.13 T2D_r2_79533_1_551_- FIG00000532 131 20 131 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_79539_1_350_- FIG00077620 4 3 6 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_79559_210_706_+ FIG00000474 125 19 125 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_r2_79599_404_706_- FIG00024930 39 7 40 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_79629_56_262_- FIG00034392 8 2 9 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_79647_152_706_- FIG00000584 110 19 111 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_79697_239_705_- FIG00000234 44 10 46 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_79698_25_705_- FIG00000402 4 3 6 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_79735_444_705_+ FIG00000155 18 4 19 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_r2_79747_1_351_+ FIG01956071 5 2 6 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_r2_79757_1_705_- FIG00030191 17 8 18 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_79853_169_704_- FIG00000494 25 6 27 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_79873_1_443_- FIG00011114 76 14 77 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_79873_481_704_- FIG00083946 24 5 26 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_79907_1_704_- FIG00000279 14 6 16 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_79944_105_329_- FIG00006764 22 4 23 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_r2_79993_1_435_+ FIG00016145 53 12 56 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_80051_254_703_- FIG00719736 8 4 11 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_80102_421_703_+ FIG00006128 18 4 22 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_80129_1_703_+ FIG00000287 107 17 109 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_80151_385_703_+ FIG00019652 22 6 23 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_r2_80158_1_703_+ FIG00561498 33 12 35 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_80160_1_365_+ FIG00052300 51 9 52 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_80177_528_702_+ FIG00000897 16 4 19 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_r2_80183_1_702_+ FIG00000390 152 25 153 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_80186_1_702_- FIG00000085 41 13 43 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_80196_1_392_+ FIG00000268 26 8 52 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_80292_282_702_- FIG00044622 68 11 69 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_80391_348_701_- FIG00031250 9 7 11 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_80409_527_701_- FIG00031250 47 7 47 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_80463_1_243_+ FIG00000164 20 4 21 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_r2_80463_350_701_+ FIG00002194 13 4 14 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_r2_80469_282_701_- FIG01955782 106 16 106 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_r2_80507_1_565_- FIG00004172 139 21 140 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_80554_453_700_+ FIG00146582 8 3 9 Putative glycogen debranching enzyme, archaeal type, TIGR01561 Glycogen metabolism 3 T2D_r2_80587_551_700_- FIG00003955 11 3 12 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_r2_80607_1_391_+ FIG00002110 53 11 54 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_r2_80640_2_700_- FIG00007957 21 10 23 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_80652_1_684_+ FIG00034392 52 13 55 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_80667_335_699_- FIG00052802 7 3 8 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_r2_80691_502_699_- FIG01304275 50 7 50 Ferrichrome transport ATP-binding protein FhuC (TC 3.A.1.14.3) Hemin transport system 1 T2D_r2_80742_1_479_- FIG00000434 44 11 47 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_80747_515_699_- FIG00000471 27 5 27 LSU ribosomal protein L34p Cell Division Subsystem including YidCD 1 T2D_r2_80748_1_271_+ FIG00000069 14 5 16 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_80846_511_698_- FIG00007957 4 2 5 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_80902_1_698_- FIG00002034 47 10 48 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_r2_80965_1_191_+ FIG00001189 7 2 8 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_81004_1_697_+ FIG00000700 65 16 69 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_r2_81007_1_697_- FIG00000329 123 22 125 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_81011_1_697_+ FIG00003844 29 9 31 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_r2_81118_1_696_- FIG00000113 32 6 35 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_81139_1_308_- FIG00000289 25 6 26 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_81150_178_696_+ FIG00005840 43 10 44 Phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_81173_1_616_+ FIG00134342 28 7 29 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_r2_81200_1_696_+ FIG00067248 132 23 133 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_81208_215_696_+ FIG00000793 54 9 55 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_81222_1_696_- FIG00018699 11 4 14 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_81237_484_696_+ FIG00000835 3 2 4 NAD-dependent malic enzyme (EC 1.1.1.38) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_81299_1_211_+ FIG00019652 10 3 11 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_r2_81366_130_603_+ FIG00010844 41 9 43 Flavodoxin Flavodoxin 1 T2D_r2_81374_1_695_- FIG00007960 201 28 201 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_81376_1_480_+ FIG00104852 14 4 15 Predicted D-lactate dehydrogenase, Fe-S protein, FAD/FMN-containing Lactate utilization 3 T2D_r2_81399_1_695_- FIG00067681 103 20 104 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_81459_1_694_+ FIG00000210 3 4 6 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_r2_81478_113_694_- FIG00000114 98 18 99 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_81506_1_456_+ FIG00000263 37 7 40 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_81506_513_694_+ FIG00000271 20 5 21 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_r2_81510_1_667_+ FIG00060517 174 25 175 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_81562_1_694_- FIG00000279 153 26 154 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_81707_1_651_- FIG00000402 55 13 56 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_81714_1_693_+ FIG00000287 93 16 97 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_81800_61_692_+ FIG01955902 6 3 7 Rubredoxin Rubrerythrin 2 T2D_r2_81833_1_692_- FIG00000402 27 11 29 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_81852_341_692_+ FIG00064110 34 8 35 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_81869_1_645_+ FIG00041038 97 20 98 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_81886_314_692_- FIG00001331 7 3 8 PTS system, galactitol-specific IIA component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_r2_81900_1_692_+ FIG01007502 75 15 78 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_81908_1_333_- FIG00000532 78 13 78 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_81908_335_691_- FIG00106349 94 14 94 Putative N-acetylgalactosaminyl-diphosphoundecaprenol glucuronosyltransferase Teichuronic acid biosynthesis 9 T2D_r2_81961_551_691_- FIG00139238 4 2 5 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_r2_81975_400_691_- FIG00059124 41 7 42 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_r2_81976_120_691_+ FIG00000155 3 2 4 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_r2_81996_47_691_- FIG00000241 128 23 129 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_82006_1_337_- FIG00000185 30 7 32 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_82013_499_691_+ FIG00000527 32 6 33 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_r2_82027_1_472_- FIG00000065 124 18 125 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_82038_1_153_- FIG00067681 33 6 33 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_82048_165_691_- FIG00002914 97 18 97 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_82064_1_690_- FIG00000157 186 28 186 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_82066_1_650_- FIG01260980 11 3 13 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_82075_83_690_+ FIG00000080 25 6 27 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_82088_1_690_+ FIG00004788 194 28 194 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_r2_82112_1_207_- FIG00000032 12 3 13 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_82179_184_690_- FIG00561498 21 5 26 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_82191_1_690_- FIG00093180 4 2 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_82255_1_489_- FIG00002049 18 9 19 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_82255_509_689_- FIG00006691 6 2 7 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_82316_1_689_- FIG00130344 73 15 74 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_82324_1_689_- FIG00000070 149 25 152 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_82335_521_689_- FIG00000624 21 4 22 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_82372_1_689_- FIG00018396 153 25 154 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_82387_414_689_+ FIG00001168 52 10 52 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_82399_1_688_+ FIG00000343 170 27 170 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_82415_1_688_- FIG00011414 4 5 17 hydrogenase, subunit gamma related protein Hydrogenases 2 T2D_r2_82425_1_626_- FIG00003555 32 10 34 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_82458_92_688_- FIG00004021 42 9 45 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_r2_82470_1_509_- FIG00027226 5 3 7 DnaJ-class molecular chaperone CbpA Protein chaperones 2.0 T2D_r2_82487_1_688_- FIG00008736 5 2 7 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_82512_312_688_+ FIG00000131 85 14 85 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_82514_302_688_- FIG00074225 11 4 13 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_82517_1_688_+ FIG00000477 84 14 86 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_82533_399_688_- FIG00000531 20 6 22 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_82561_1_191_- FIG00000434 24 5 25 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_82565_1_688_- FIG00000025 3 4 5 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_82575_1_232_- FIG00073301 4 2 5 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_82578_1_616_- FIG00000151 84 16 86 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_r2_82592_1_290_+ FIG01304530 36 9 37 Phage terminase, large subunit Phage head and packaging 1 T2D_r2_82604_1_217_+ FIG00000184 9 4 10 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_82625_223_687_- FIG00000040 22 5 23 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r2_82651_1_316_+ FIG00067681 9 3 10 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_82682_1_687_- FIG00067248 155 24 156 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_82686_1_213_- FIG00001106 37 7 38 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_r2_82688_1_687_- FIG00000146 118 21 119 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_82754_1_684_+ FIG00093180 185 27 186 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_82779_16_686_+ FIG00006691 3 4 8 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_82785_202_555_+ FIG00000770 34 7 37 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_r2_82802_1_264_- FIG00003751 26 6 27 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_r2_83008_1_489_+ FIG00138613 8 3 10 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.13.3) Aromatic Amin Catabolism 7 T2D_r2_83062_1_515_+ FIG00000114 114 19 115 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_83082_68_684_- FIG00000025 15 8 18 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_83092_1_684_+ FIG00026137 193 28 193 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_83116_1_472_+ FIG00007508 18 5 19 Nitrite reductase probable [NAD(P)H] subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_r2_83204_373_684_- FIG00002049 20 4 21 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_83210_1_684_- FIG00139058 178 26 178 Putrescine/proton symporter, putrescine/ornithine antiporter PotE Polyamine Metabolism 2 T2D_r2_83248_92_683_- FIG00000803 115 20 116 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_r2_83279_143_683_- FIG00001168 14 5 17 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_83304_1_260_- FIG00010738 9 3 11 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_r2_83310_1_683_- FIG00049915 59 14 62 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_r2_83341_278_683_- FIG00000408 90 15 90 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_r2_83347_1_249_- FIG00133139 15 5 16 Superoxide dismutase [Fe] (EC 1.15.1.1) Oxidative stress 1.2 T2D_r2_83347_349_683_+ FIG00001067 11 3 13 Rubrerythrin Oxidative stress 1.2 T2D_r2_83357_1_405_+ FIG00136692 9 4 11 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_83357_420_683_+ FIG00000433 32 7 34 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_83385_1_632_+ FIG00005237 10 3 12 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_r2_83386_1_639_+ FIG00010771 140 24 141 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_83461_1_231_+ FIG00000762 6 3 7 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_r2_83472_1_413_- FIG00000221 47 11 49 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_83472_415_682_- FIG00046929 31 7 32 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_83512_1_682_- FIG00002470 53 10 54 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_83521_1_682_+ FIG00006235 150 24 150 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_r2_83533_1_682_+ FIG00000116 28 8 32 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_83544_1_343_- FIG00000387 50 10 51 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_r2_83570_1_682_+ FIG00026918 24 9 29 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_83597_1_318_- FIG00076542 32 7 33 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_r2_83616_1_681_+ FIG00000365 181 28 183 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_83645_194_681_+ FIG00133292 19 6 22 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_83692_1_681_- FIG00000221 19 6 23 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_83744_1_254_- FIG00000131 18 4 19 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_83776_264_680_+ FIG00008490 68 13 69 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_83797_152_680_+ FIG00004170 7 3 9 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_r2_83799_1_641_- FIG00003520 54 12 59 Phage tail fiber protein Phage tail fiber proteins 2 T2D_r2_83801_1_546_+ FIG00020185 49 13 51 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_83801_551_680_+ FIG00006551 6 2 7 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_83807_1_424_+ FIG00000156 25 6 27 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_83845_1_680_- FIG00067681 137 24 139 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_83859_219_680_- FIG00018369 57 11 58 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_83876_1_190_+ FIG00003435 9 3 10 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_83969_1_651_+ FIG00043720 34 9 35 Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) Arginine and Ornithine Degradation 1.34 T2D_r2_83988_53_472_- FIG01955919 10 4 11 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_84077_1_209_- FIG00000202 10 4 11 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_84179_249_678_+ FIG00000317 11 5 12 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_84251_54_678_- FIG00000173 120 22 121 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_r2_84269_1_677_- FIG00028882 151 25 151 D-glycerate transporter (predicted) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_84367_1_677_- FIG00000402 49 13 51 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_84385_1_677_- FIG00006151 66 12 71 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_84416_204_542_- FIG00000219 89 13 89 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_r2_84474_369_676_+ FIG00000380 29 7 31 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_84493_419_676_+ FIG00000659 73 10 73 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_84495_1_490_- FIG00018865 23 8 25 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_84538_1_676_+ FIG00083946 72 16 74 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_84592_70_676_- FIG00019251 6 5 8 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_84615_1_271_+ FIG00000303 19 5 20 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_r2_84640_330_675_+ FIG00000711 85 13 85 Phosphoenolpyruvate carboxylase (EC 4.1.1.31) Serine-glyoxylate cycle 1 T2D_r2_84687_1_484_+ FIG00028476 41 9 44 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_84776_1_675_+ FIG00028461 22 6 25 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_84788_1_420_+ FIG00023004 38 7 39 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_84796_1_193_+ FIG00018369 17 5 19 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_84820_1_674_- FIG00006128 3 2 5 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_84869_1_395_+ FIG00001088 9 3 10 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_84953_1_241_- FIG00010454 20 4 21 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_84957_1_674_- FIG00000377 10 2 12 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_84977_1_674_+ FIG00000329 112 20 114 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_84987_182_673_- FIG00000601 125 19 125 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_85032_1_503_+ FIG00000055 115 20 115 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_r2_85054_1_522_+ FIG00000456 13 5 15 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_r2_85060_1_673_+ FIG00000365 50 14 52 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_85074_1_673_+ FIG00000838 27 9 28 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_85100_350_673_+ FIG00000194 24 7 25 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_r2_85146_456_673_+ FIG01280345 8 4 10 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_r2_85160_97_672_+ FIG00058998 32 7 34 Vancomycin response regulator VanR Resistance to Vancomycin X T2D_r2_85163_1_637_+ FIG00000080 29 7 32 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_85185_1_672_+ FIG00001385 178 26 178 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_85189_1_672_+ FIG00000289 68 17 71 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_85249_1_149_+ FIG00000645 33 5 33 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_r2_85290_1_672_+ FIG00089870 16 6 20 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_r2_85312_297_672_+ FIG00000425 19 5 24 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_r2_85325_1_397_+ FIG00006032 87 15 88 Cobalamin synthase Cobalamin synthesis 2 T2D_r2_85344_1_671_+ FIG00034851 3 4 5 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_85357_397_671_+ FIG00001170 25 6 26 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_r2_85385_518_671_+ FIG00006151 18 5 18 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_85433_120_671_- FIG00000985 6 2 8 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_r2_85443_1_671_- FIG00034392 35 9 36 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_85494_362_670_+ FIG00000234 44 9 45 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_85530_1_670_- FIG00014764 87 13 89 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_r2_85534_88_670_- FIG00042275 6 2 8 ABC transport system, permease component YbhR ATP-dependent efflux pump transporter Ybh 1 T2D_r2_85543_19_670_+ FIG00001670 17 5 20 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_r2_85570_1_670_+ FIG00000333 71 16 73 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_85573_1_670_- FIG00010454 29 12 31 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_85575_1_670_- FIG00561498 32 8 34 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_85623_1_544_- FIG00000380 41 9 43 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_85657_1_272_- FIG00001076 74 10 74 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_85696_1_627_+ FIG00000280 37 13 39 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_85699_1_183_- FIG00001406 17 5 19 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_85704_15_575_+ FIG00000402 18 6 21 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_85711_1_366_- FIG00006092 81 13 81 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_85737_264_669_+ FIG00064110 26 9 29 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_85749_1_669_+ FIG00051439 118 20 119 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_85801_1_282_+ FIG00003715 4 3 6 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_85840_1_668_+ FIG00010134 56 14 59 Methionine transporter MetT Methionine Degradation 3 T2D_r2_85910_1_668_+ FIG01955975 165 26 165 [Ni/Fe] hydrogenase, group 1, large subunit Hydrogenases 2 T2D_r2_85972_1_668_+ FIG00000139 7 3 9 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_85999_1_270_- FIG00009014 41 7 42 Anaerobic sulfite reductase subunit C (EC 1.8.1.-) Anaerobic respiratory reductases 3 T2D_r2_86022_1_167_+ FIG00003555 30 6 30 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_86022_174_667_+ FIG01297554 81 14 83 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_r2_86023_1_667_- FIG00080955 169 26 169 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_86040_1_376_+ FIG00002041 92 14 92 Flagellar motor switch protein FliN Bacterial Chemotaxis 9 T2D_r2_86171_1_465_- FIG00023071 3 2 5 Multiple sugar metabolism regulator Streptococcus pyogenes recombinatorial zone 8 T2D_r2_86193_1_666_+ FIG00451095 6 4 9 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_86235_1_424_+ FIG00000219 18 5 20 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_r2_86300_410_666_+ FIG00000449 18 7 19 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_r2_86323_144_666_- FIG00000328 40 9 42 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_r2_86328_1_630_+ FIG00000391 36 9 40 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_r2_86334_451_666_+ FIG00000155 27 6 28 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_r2_86345_1_240_- FIG00002716 14 3 16 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_r2_86347_1_381_+ FIG00041038 14 6 16 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_86350_1_241_+ FIG00000132 12 3 13 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_86401_1_665_+ FIG00022996 28 8 31 Aconitate hydratase (EC 4.2.1.3) Serine-glyoxylate cycle 1 T2D_r2_86421_1_207_- FIG00000015 42 7 43 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_86421_318_665_- FIG00000214 89 13 89 LSU ribosomal protein L19p Ribosome LSU bacterial 9 T2D_r2_86445_421_665_- FIG00846773 55 9 55 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_86454_195_665_- FIG00001088 17 6 19 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_86486_1_399_+ FIG00006868 99 15 99 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_r2_86495_1_404_+ FIG00006151 70 13 71 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_86495_406_665_+ FIG00045144 40 8 41 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_r2_86514_1_487_+ FIG00000015 35 10 37 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_86535_37_664_+ FIG00018369 177 24 177 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_86689_1_307_+ FIG00000055 8 3 10 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_r2_86741_51_521_+ FIG00000209 57 12 58 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_86749_1_506_+ FIG00000089 127 19 127 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_r2_86784_1_255_+ FIG00000243 10 5 12 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_86806_1_663_+ FIG00000672 63 12 65 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_86834_1_545_+ FIG00000343 51 10 53 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_86837_1_345_- FIG00000641 3 2 5 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_86847_1_470_+ FIG00032483 17 6 20 PTS system, fructose- and mannose-inducible IID component (EC 2.7.1.69) Fructose and Mannose Inducible PTS 2 T2D_r2_86877_1_655_+ FIG00023004 24 5 28 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_87012_1_483_+ FIG01306479 42 8 43 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_87014_1_619_+ FIG00000402 127 20 128 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_87030_1_411_+ FIG00018396 97 15 97 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_87038_1_662_+ FIG00000350 83 16 84 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_87048_1_229_- FIG01007502 6 2 8 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_87102_1_343_- FIG00000383 9 4 11 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_r2_87133_1_411_+ FIG00066264 4 2 5 ATP-dependent DNA helicase UvrD/PcrA, clostridial paralog 2 DNA repair, bacterial UvrD and related helicases 1 T2D_r2_87150_384_661_+ FIG00066575 68 11 68 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_87170_1_189_+ FIG01303788 9 2 10 3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 4.1.99.12) riboflavin to FAD 1 T2D_r2_87363_307_660_+ FIG00001106 28 8 29 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_r2_87382_1_660_+ FIG00000116 36 8 38 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_87390_378_660_- FIG00000065 46 9 48 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_87474_1_323_- FIG00000445 61 11 62 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_r2_87474_378_659_- FIG00136692 32 8 35 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_87480_1_659_- FIG01292786 171 26 171 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_r2_87491_1_174_+ FIG00000815 37 6 37 Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE Biogenesis of c-type cytochromes 1.1 T2D_r2_87507_1_498_+ FIG00455853 11 6 13 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_87521_1_498_+ FIG00000185 4 3 5 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_87574_135_659_+ FIG00010844 16 4 19 Flavodoxin Flavodoxin 1 T2D_r2_87647_351_658_+ 4 3 18 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_87810_1_220_- FIG00000101 10 4 12 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_r2_87823_1_539_+ FIG00025216 16 5 19 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_87857_1_657_+ FIG00041382 178 25 178 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_87884_1_657_- FIG00002416 45 12 47 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_r2_87885_469_657_+ FIG00000243 44 7 44 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_87926_357_657_+ FIG00093180 14 3 15 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_87933_285_539_- FIG00000325 3 2 4 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_87939_170_657_- FIG00002561 124 19 127 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_87970_102_584_+ FIG00001331 11 4 13 PTS system, galactitol-specific IIA component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_r2_88015_1_614_- FIG00000241 66 13 68 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_88034_1_323_- FIG00001175 6 3 8 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_88044_1_471_- FIG00003002 9 4 12 HtrA protease/chaperone protein Periplasmic Stress Response 1.1 T2D_r2_88113_43_656_- FIG00042781 36 10 38 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_88186_1_656_+ FIG00623809 101 16 103 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_88226_1_245_+ FIG00000401 61 9 61 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_88295_512_655_+ FIG00003090 5 2 7 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_r2_88356_1_655_- FIG01583289 29 8 33 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_r2_88358_476_655_+ FIG00066643 12 3 12 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_88373_474_655_+ FIG00075970 41 6 41 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_88450_1_580_- FIG00093180 10 4 11 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_88451_167_421_+ FIG00001133 28 7 30 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_r2_88454_1_654_+ FIG00003788 145 23 146 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_88554_1_544_+ FIG00229199 39 8 41 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_r2_88657_1_232_+ FIG00041038 5 2 6 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_88684_26_508_- FIG00000494 83 14 84 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_88729_1_398_+ FIG00000913 93 15 93 Ribonuclease E (EC 3.1.26.12) RNA processing and degradation, bacterial 1 T2D_r2_88789_272_652_- FIG00945384 22 7 23 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_88849_1_571_+ FIG00140555 88 15 89 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_88853_107_598_+ FIG00621884 20 5 22 Hydrogenase maturation protease (EC 3.4.24.-) Hydrogenases 2 T2D_r2_88904_1_406_+ FIG00001893 38 8 39 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_r2_88910_1_359_- FIG00138523 28 6 29 Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_r2_88972_445_651_- FIG00000055 14 4 15 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_r2_88995_71_400_- FIG00229199 32 6 33 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_r2_88996_1_480_- FIG00000459 112 17 114 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_89049_265_651_- FIG00046929 17 6 19 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_89054_1_651_+ FIG00004764 104 18 105 Ammonium transporter Ammonia assimilation 1 T2D_r2_89099_1_200_+ FIG00047414 34 6 36 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_89099_208_651_+ FIG00000013 5 3 8 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_89100_1_651_- FIG00000173 158 23 160 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_r2_89147_225_650_+ FIG00006700 18 5 20 RNA binding protein, contains ribosomal protein S1 domain Cell division-ribosomal stress proteins cluster 1 T2D_r2_89148_216_650_+ FIG00000001 98 15 98 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_89156_1_474_+ FIG00000402 5 4 6 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_89193_450_650_- FIG00030797 45 7 45 C4-type zinc finger protein, DksA/TraR family Zinc regulated enzymes 1 T2D_r2_89204_1_650_- FIG00000395 37 9 39 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_89227_112_650_+ FIG00000243 16 5 18 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_89261_1_650_- FIG00042616 24 6 27 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_89292_1_650_- FIG00001209 106 20 107 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_89295_311_650_+ FIG00000131 21 5 22 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_89346_1_649_- FIG00003435 9 6 12 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_89392_1_220_+ FIG00904859 4 2 5 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_r2_89425_314_502_+ FIG00006632 7 4 9 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_r2_89453_1_649_- FIG01299858 156 25 156 Energy-conserving hydrogenase (ferredoxin), subunit A NiFe hydrogenase maturation 1 T2D_r2_89474_1_334_- FIG00000695 12 3 14 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_89474_380_649_- FIG00000695 4 2 5 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_89530_1_648_- FIG00028461 8 3 11 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_89548_1_648_- FIG00001548 61 13 62 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_89552_1_520_+ FIG00006691 17 6 19 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_89554_1_171_+ FIG00000352 18 4 19 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r2_89556_1_648_- FIG00031723 22 6 24 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_r2_89581_58_648_- FIG00066643 38 8 39 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_89673_1_647_+ FIG00000404 72 14 73 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_89717_25_647_+ FIG00006955 173 25 173 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_r2_89726_1_342_+ FIG00229199 17 6 18 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_r2_89768_245_556_- FIG00000276 78 12 78 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_r2_89795_281_647_- FIG00004172 67 12 67 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_89802_1_647_+ FIG00000793 81 14 83 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_89810_1_647_+ FIG00093180 16 8 19 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_89830_1_147_+ FIG00032749 37 6 37 Protein YicC CBSS-323097.3.peg.2594 1 T2D_r2_89886_387_646_- FIG00000426 16 5 17 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY Bacterial Chemotaxis 9 T2D_r2_89897_476_646_+ FIG01955919 36 6 36 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_89953_1_646_- FIG00000402 55 14 56 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_89963_266_646_+ FIG00083946 22 6 24 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_90127_319_645_- FIG00000032 31 7 32 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_90187_129_449_+ FIG00007373 16 3 17 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_r2_90217_1_645_+ FIG00000672 36 10 38 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_90241_1_317_+ FIG00000539 33 7 35 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_90265_1_335_- FIG00000659 25 6 26 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_90300_1_587_- FIG00000863 45 11 47 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_r2_90451_1_643_+ FIG00138468 26 8 27 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_90476_1_643_+ FIG00000741 167 24 167 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_r2_90490_1_333_- FIG00001750 70 11 70 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_90514_1_643_- FIG00537822 13 5 15 Heavy-metal-associated domain (N-terminus) and membrane-bounded cytochrome biogenesis cycZ-like domain, possible membrane copper tolerance protein Biogenesis of cbb3-type cytochrome c oxidases 9 T2D_r2_90535_1_395_+ FIG00002240 97 15 97 Transcriptional regulatory protein CitB, DpiA CitAB 1 T2D_r2_90548_1_175_+ FIG00015729 24 5 25 LSU ribosomal protein L29p (L35e) Ribosome LSU bacterial 9 T2D_r2_90552_1_513_+ FIG00000343 18 5 19 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_90581_1_643_- FIG00002974 16 6 19 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_r2_90587_1_336_+ FIG00004078 97 13 97 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_90615_1_643_+ FIG00229386 17 6 21 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_90647_194_642_+ FIG00000601 51 12 52 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_90682_1_642_+ FIG00008230 21 8 23 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_r2_90685_1_642_- FIG00034392 124 22 125 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_90702_183_599_+ FIG00092649 7 2 8 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_r2_90744_1_397_- FIG00000261 24 7 25 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_90750_1_440_+ FIG00017311 17 5 20 Capsular polysaccharide export system periplasmic protein KpsD Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_r2_90755_1_642_- FIG00001354 102 19 105 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_r2_90834_1_261_+ FIG00001932 18 3 19 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_90858_1_312_+ FIG00002342 76 11 77 Muconolactone isomerase (EC 5.3.3.4) Benzoate degradation 3 T2D_r2_90879_1_641_- FIG00062054 105 16 110 Putative glycosyltransferase protein CBSS-258594.1.peg.3339 1 T2D_r2_90911_117_641_- FIG00132617 56 13 58 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_90947_1_134_- FIG00000412 30 5 30 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_90947_311_517_- FIG00002958 51 8 51 FIG002958: hypothetical protein Hypothetical Coupled to RecF 1 T2D_r2_90954_1_641_+ FIG00002541 112 20 114 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_90961_1_641_- FIG00554193 47 11 49 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_91019_1_205_+ FIG00000770 20 3 21 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_r2_91040_356_640_- FIG00000372 3 2 5 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_91150_1_232_+ FIG00051313 52 8 52 ATPase component NikO of energizing module of nickel ECF transporter ECF class transporters 345678 T2D_r2_91150_291_640_+ FIG01007502 3 4 6 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_91231_171_639_- FIG00060517 16 6 17 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_91252_1_639_- FIG00034293 30 7 32 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_91335_22_639_+ FIG00001670 45 12 48 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_r2_91362_1_411_+ FIG00001029 42 7 44 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_r2_91378_1_639_- FIG00000531 67 13 80 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_91416_1_638_+ FIG01955844 157 24 157 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_91444_1_638_+ FIG00000402 41 10 42 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_91474_1_133_- FIG01961546 7 2 8 DNA repair protein RadC DNA repair, bacterial 3 T2D_r2_91482_1_551_+ FIG00035893 131 21 131 Nickel ABC transporter, periplasmic nickel-binding protein NikA (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_r2_91537_1_359_+ FIG01266244 8 3 10 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_91579_1_638_+ FIG00000412 27 7 29 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_91586_76_638_- FIG00004172 3 2 4 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_91596_1_366_- FIG00009544 4 2 5 Late competence protein ComEA, DNA receptor Gram Positive Competence 3100 T2D_r2_91600_441_638_- FIG01260980 39 7 40 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_91609_174_638_- FIG00017190 8 2 10 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_91653_1_505_+ FIG00010524 39 9 41 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_91659_1_637_+ FIG00000264 154 25 154 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_r2_91663_267_637_+ FIG00000273 36 9 37 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_r2_91677_1_637_+ FIG00001530 11 5 17 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_r2_91735_1_637_- FIG00001406 126 22 128 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_91743_50_637_+ FIG01304043 6 3 8 Competence/damage-inducible protein CinA CBSS-257314.1.peg.676 4.x T2D_r2_91772_1_637_- FIG00021289 11 5 14 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_91819_1_636_+ FIG00046929 67 15 70 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_91829_353_636_- FIG00002332 19 4 20 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_r2_91873_1_636_+ FIG00000838 62 12 63 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_91889_1_636_+ FIG01583289 7 3 9 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_r2_91965_1_636_+ FIG00031250 122 19 133 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_91989_385_636_- FIG00126843 19 5 20 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_92017_1_635_- FIG00024851 108 18 109 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_92024_15_413_- FIG00000402 12 3 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_92130_1_299_- FIG00044478 20 4 21 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_92182_1_635_- FIG00005710 138 23 138 Beta-lactamase class A Beta-lactamase 1 T2D_r2_92185_1_477_- FIG00104848 36 7 37 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_92234_1_347_- FIG00000446 42 10 43 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_92264_185_634_+ FIG00036406 8 3 11 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_r2_92266_343_634_- FIG00000202 22 6 23 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_92290_1_311_- FIG00006254 12 3 13 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) L-ascorbate utilization (and related gene clusters) 29 T2D_r2_92317_1_634_- FIG00000145 85 17 86 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_r2_92343_1_260_+ FIG00000430 16 4 17 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_r2_92343_271_634_+ FIG00000022 6 3 8 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_r2_92360_1_280_- FIG00007495 8 2 9 Spore maturation protein B Spore Core Dehydration 1.1 T2D_r2_92360_282_634_- FIG00003439 12 3 13 Spore maturation protein A Spore Core Dehydration 1.1 T2D_r2_92397_1_323_+ FIG00000421 26 8 28 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_r2_92435_1_633_+ FIG00134060 59 15 61 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_92439_1_389_- FIG00046358 28 8 29 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_92465_1_633_+ FIG00008736 18 7 21 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_92475_425_633_+ FIG00001824 46 7 46 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_92489_1_313_- FIG00000402 39 8 41 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_92496_447_633_- FIG00000301 16 5 17 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_r2_92507_1_309_+ FIG00000420 24 5 25 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_92512_163_633_- FIG00001170 12 3 14 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_r2_92538_1_358_- FIG00000437 4 3 5 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_92538_364_633_- FIG00000420 6 2 8 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_92634_1_614_- FIG00001882 127 20 129 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_r2_92649_171_632_- FIG01266244 36 7 38 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_92651_1_227_- FIG00002803 13 4 14 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_92651_255_632_- FIG00000401 11 5 12 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_92654_1_189_+ FIG00134167 29 5 30 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_92678_1_319_+ FIG00001011 15 3 16 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_r2_92744_1_632_- FIG00003410 18 6 20 Tagatose-6-phosphate kinase AgaZ (EC 2.7.1.144) N-Acetyl-Galactosamine and Galactosamine Utilization B.x T2D_r2_92763_1_632_+ FIG00036983 96 18 120 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_92789_448_632_- FIG00000103 23 4 25 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_92899_1_631_- FIG00001932 29 7 32 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_92927_24_631_- FIG00011114 98 19 100 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_92955_1_521_- FIG00623809 29 7 30 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_93019_1_630_+ FIG00000858 104 18 105 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_r2_93030_1_207_+ FIG00002799 56 8 56 Phosphoheptose isomerase 1 (EC 5.3.1.-) Capsular heptose biosynthesis 1 T2D_r2_93049_248_630_+ FIG00000510 44 11 45 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_r2_93060_1_156_- FIG00058830 12 3 13 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_93083_1_630_+ FIG00000176 176 26 176 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_93091_38_630_+ FIG00000040 153 22 153 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r2_93111_39_473_+ FIG00000621 118 17 118 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_93152_8_630_+ FIG00001642 18 6 20 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_93235_1_629_+ FIG00002489 14 6 17 Spore germination protein GerKA Spore germination 1 T2D_r2_93243_1_629_- FIG00001621 4 2 6 FIG001621: Zinc protease CBSS-257314.1.peg.676 4.x T2D_r2_93290_1_629_+ FIG00002320 6 3 8 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_r2_93345_1_629_+ FIG00000122 166 25 167 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_93350_1_629_+ FIG00000695 69 12 77 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_93474_273_628_+ FIG00000355 26 7 28 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_93519_339_628_- FIG00000351 36 8 37 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_r2_93530_34_628_- FIG00000402 30 8 33 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_93542_259_628_- FIG00004761 9 3 10 Formate dehydrogenase O gamma subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_r2_93600_1_627_+ FIG00000080 81 18 83 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_93606_488_627_+ FIG00000156 37 5 37 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_93620_306_627_- FIG00013534 13 2 15 Substrate-specific component BL0695 of predicted ECF transporter ECF class transporters 345678 T2D_r2_93692_1_496_+ FIG00602994 15 5 17 Predicted glycolate dehydrogenase, 2-subunit type (EC 1.1.99.14), iron-sulfur subunit GlcF Glycolate, glyoxylate interconversions ? T2D_r2_93752_1_627_- FIG01260980 184 25 184 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_93762_1_627_- FIG00001469 37 10 38 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_93842_1_626_- FIG00080955 51 11 52 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_93873_482_626_- FIG00000430 20 3 20 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_r2_93892_1_626_- FIG00042616 84 17 86 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_93916_1_626_+ FIG00001547 9 4 11 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_93991_329_625_- FIG00018369 31 6 32 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_94004_1_625_- FIG00000762 30 11 32 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_r2_94008_1_243_+ FIG00028203 39 7 39 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_94067_16_327_- FIG00000380 40 7 41 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_94071_353_625_- FIG00028694 28 5 29 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_r2_94149_393_625_- FIG00000103 15 3 16 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_94164_1_534_- FIG00002689 4 2 6 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_94182_1_625_+ FIG00010508 54 13 55 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_94203_1_624_+ FIG00044622 107 14 109 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_94213_1_624_+ FIG00000146 157 23 157 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_94266_324_624_+ FIG00016663 9 4 11 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_94314_20_574_- FIG00000494 11 7 13 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_94328_121_624_+ FIG00028694 28 7 29 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_r2_94333_112_624_+ FIG00133569 9 4 12 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_r2_94357_264_624_+ FIG00000402 13 5 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_94389_1_415_+ FIG00008656 107 16 108 Regulatory protein (induces abgABT, used to catabolize p-aminobenzoyl-glutamate) p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_94390_1_480_+ FIG00020185 97 17 99 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_94390_482_624_+ FIG00006551 23 4 23 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_94393_192_623_- FIG00000721 5 2 6 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_94399_1_448_+ FIG00017454 115 17 116 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_94439_1_598_+ FIG00001088 14 4 15 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_94516_1_623_+ FIG00129616 69 15 71 GTP-binding protein EngA Universal GTPases 2 T2D_r2_94553_1_196_- FIG00000402 40 7 40 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_94559_1_270_+ FIG00000098 51 9 52 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_94572_1_515_+ FIG00000111 77 16 79 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_94591_1_622_- FIG00066504 37 12 39 Glucarate dehydratase (EC 4.2.1.40) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_94599_1_622_- FIG01318398 26 6 29 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_94604_1_622_+ FIG00046929 57 13 59 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_94643_1_622_- FIG00017431 183 25 183 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_r2_94658_165_622_- FIG00945384 41 8 45 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_94664_273_622_- FIG00135554 17 5 19 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_r2_94714_1_622_+ FIG00000176 80 16 81 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_94766_1_282_- FIG00008348 26 6 27 Predicted transcriptional regulator of N-Acetylglucosamine utilization, GntR family Chitin and N-acetylglucosamine utilization 2 T2D_r2_94768_1_227_- FIG00000358 25 6 26 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_r2_94772_1_597_+ FIG00051313 5 5 8 ATPase component NikO of energizing module of nickel ECF transporter ECF class transporters 345678 T2D_r2_94813_238_621_- FIG00000081 10 4 11 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_94941_1_582_+ FIG00134135 44 10 48 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_94986_1_621_- FIG00042781 33 9 34 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_94987_1_581_- FIG00000268 79 16 80 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_94996_1_620_+ FIG00137374 140 23 140 ATP-dependent DNA helicase SCO5184 DNA repair, bacterial RecBCD pathway 3 T2D_r2_95000_1_620_- FIG00002194 15 5 17 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_r2_95001_1_344_+ FIG00037273 48 9 49 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_r2_95001_405_620_+ FIG00000191 31 8 33 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_95035_394_620_- FIG00000143 53 8 53 Translation initiation factor 1 Translation initiation factors bacterial 1.111 T2D_r2_95048_1_620_- FIG00008474 4 7 11 ABC-type tungstate transport system, permease protein ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_95073_1_620_- FIG00451095 20 8 21 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_95078_1_388_+ FIG00122145 69 13 71 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_95078_405_620_+ FIG00000076 20 5 21 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_95131_1_311_- FIG00081563 6 3 7 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_r2_95143_1_344_- FIG00007960 14 5 16 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_95166_1_203_- FIG00000221 19 5 21 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_95170_1_620_- FIG00028476 5 3 7 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_95204_1_620_+ FIG00001548 173 24 173 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_95223_336_619_+ FIG00000314 12 2 13 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_r2_95231_401_619_+ FIG00002848 6 2 7 Nicotinamide phosphoribosyltransferase (EC 2.4.2.12) NAD and NADP cofactor biosynthesis global E T2D_r2_95311_1_619_+ FIG00061313 12 5 14 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_r2_95326_1_507_+ FIG00001385 7 2 8 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_95335_1_569_+ FIG00000126 42 13 44 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_95360_1_307_- FIG00000200 40 7 42 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_r2_95448_1_618_+ FIG00000087 154 23 154 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_r2_95471_1_438_- FIG00006235 3 2 4 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_r2_95480_1_209_- FIG00132617 13 3 14 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_95480_355_618_- FIG00074225 26 6 28 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_95492_1_485_+ FIG00000395 17 6 19 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_95502_205_618_- FIG01955782 17 4 19 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_r2_95515_1_188_- FIG00009149 3 3 4 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_95554_264_618_+ FIG00134943 88 14 88 Periplasmic [Fe] hydrogenase small subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_95674_1_215_- FIG00000207 44 7 45 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_95697_1_557_+ FIG00000258 64 13 65 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_r2_95732_94_617_+ FIG00013811 124 18 125 Periplasmic thiol:disulfide interchange protein DsbA Periplasmic disulfide interchange 1 T2D_r2_95747_1_483_+ FIG00031250 6 3 7 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_95773_1_617_+ FIG00000011 9 4 11 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_95793_1_617_+ FIG00002695 167 23 168 Biosynthetic arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_95829_1_610_+ FIG00021517 17 5 20 Cell division protein FtsQ Cell Division Cluster 1.x T2D_r2_95870_29_616_- FIG01955857 119 20 119 Sensor protein of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_95879_227_616_+ FIG00035175 22 6 24 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_95890_1_515_- FIG00003672 12 5 13 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_r2_95988_135_616_- FIG00046929 33 9 35 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_96041_160_616_- FIG00000116 22 6 23 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_96109_1_531_+ FIG00010194 5 2 7 Cell wall surface anchor family protein Sortase 1.12 T2D_r2_96165_1_615_+ FIG00031723 9 4 11 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_r2_96197_300_615_- FIG00048580 12 3 13 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_r2_96224_1_217_+ FIG00008490 40 8 41 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_96240_220_615_+ FIG00000208 56 9 57 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_r2_96269_417_614_- FIG00598409 14 4 16 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_r2_96320_1_171_+ FIG00138538 34 7 34 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_r2_96323_1_614_- FIG00029916 162 24 163 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_r2_96369_1_330_+ FIG00050603 5 2 7 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_96369_385_614_+ FIG00000504 10 2 11 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_96421_278_544_+ FIG00000659 4 3 7 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_96462_124_318_- FIG00084255 7 2 8 Stage III sporulation protein AC Sporulation Cluster III A 1.x T2D_r2_96535_1_613_+ FIG01255877 22 8 25 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_r2_96539_145_613_- FIG00001635 20 8 23 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_96563_1_536_- FIG00058830 98 18 99 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_96570_1_613_+ FIG00041038 15 6 17 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_96635_1_329_+ FIG00003751 15 3 17 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_r2_96660_1_613_- FIG00133578 144 23 144 Uptake hydrogenase small subunit precursor (EC 1.12.99.6) Hydrogenases 2 T2D_r2_96693_1_612_- FIG00000380 12 4 14 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_96694_1_360_- FIG00001000 46 8 48 Sulfate and thiosulfate binding protein CysP Cysteine Biosynthesis 2.17 T2D_r2_96704_99_612_+ FIG00000140 87 15 88 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_96723_424_612_- FIG00000235 37 6 38 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_96727_1_612_- FIG00000434 66 14 67 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_96768_1_612_+ FIG00051439 38 11 40 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_96801_1_602_+ FIG00000695 16 6 19 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_96822_1_289_+ FIG00018536 77 11 77 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_96822_290_612_+ FIG00022976 81 12 81 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_96824_1_231_+ FIG00006691 3 2 4 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_96838_366_612_- FIG00000235 13 2 14 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_96902_1_572_- FIG00000865 33 8 36 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_r2_96957_1_611_+ FIG00000086 7 4 8 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_r2_97000_236_490_+ FIG00000394 17 4 20 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_97011_1_611_- FIG00079822 24 7 27 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_97015_409_611_+ FIG00561498 13 3 15 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_97030_145_611_+ FIG00126843 9 5 11 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_97054_1_611_- FIG00000402 27 9 30 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_97109_384_611_- FIG00000897 18 4 20 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_r2_97110_1_611_+ FIG00000101 81 17 82 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_r2_97156_160_610_- FIG01260980 11 5 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_97157_60_610_- FIG01304998 3 3 5 RND efflux system, membrane fusion protein CmeA Multidrug Resistance Efflux Pumps 1.12 T2D_r2_97208_1_395_- FIG00050603 107 16 107 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_97228_1_222_- FIG00004037 4 3 5 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_97228_251_610_- FIG00007514 29 6 30 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_97236_1_610_- FIG00000107 53 11 55 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_r2_97239_1_610_- FIG00028461 55 12 56 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_97252_1_234_+ FIG00000121 8 2 10 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_r2_97297_1_610_+ FIG00719736 85 16 87 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_97314_1_610_- FIG00018396 52 14 53 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_97321_1_365_- FIG00018369 97 14 97 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_97389_1_273_+ FIG00000028 39 7 41 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r2_97389_283_609_+ FIG00000241 29 7 31 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_97392_1_159_+ FIG00340292 6 2 7 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_97421_1_286_+ FIG00000762 73 10 73 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_r2_97443_154_504_- FIG00001635 36 6 37 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_97457_1_609_- FIG00046929 9 6 11 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_97520_1_609_- FIG00138258 155 23 155 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_97623_1_608_- FIG00000402 33 10 35 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_97650_1_345_+ FIG00001449 12 4 13 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_r2_97657_1_608_- FIG00041038 17 6 19 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_97709_243_608_- FIG00080955 13 4 14 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_97727_1_608_+ FIG00058830 63 13 65 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_97780_143_592_+ FIG00001548 118 16 118 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_97856_1_607_- FIG00009194 19 6 20 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_97863_1_165_+ FIG00002541 42 6 42 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_97902_1_607_- FIG00000395 37 8 39 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_97907_1_434_- FIG00135048 39 10 41 Polysulfide reductase, subunit B, putative Anaerobic respiratory reductases 3 T2D_r2_97975_155_606_+ FIG00719736 112 16 113 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_97990_1_383_- FIG00000614 3 2 5 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_r2_98082_1_606_- FIG00079521 16 7 19 TRAP dicarboxylate transporter, DctM subunit, unknown substrate 8 CBSS-49338.1.peg.459 1 T2D_r2_98114_283_606_+ FIG00000832 69 12 69 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_r2_98132_1_606_+ FIG00003002 109 18 110 HtrA protease/chaperone protein Periplasmic Stress Response 1.1 T2D_r2_98135_70_606_- FIG00000840 15 6 17 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_r2_98181_56_605_+ FIG00001818 72 15 73 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_r2_98194_1_605_+ FIG00003299 33 7 35 L-arabinose-binding periplasmic protein precursor AraF (TC 3.A.1.2.2) L-Arabinose utilization 1 T2D_r2_98206_1_243_+ FIG00000296 56 9 56 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_r2_98315_1_605_+ FIG00000102 17 5 19 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_98375_1_254_- FIG00003894 22 6 23 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_98375_291_551_+ FIG00013339 3 2 4 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_98384_1_605_- FIG01304601 9 5 11 Exonuclease SbcC DNA repair, bacterial 3 T2D_r2_98387_1_605_+ FIG00000242 55 12 57 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_98420_1_604_+ FIG00059211 98 18 99 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_98440_56_505_+ FIG00003270 71 14 72 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_r2_98444_1_287_- FIG00000395 39 8 40 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_98497_1_604_+ FIG00002646 3 3 5 Transcriptional activator of acetoin dehydrogenase operon AcoR Acetoin, butanediol metabolism 5 T2D_r2_98630_1_603_+ FIG00000102 72 13 74 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_98673_185_603_+ FIG00095112 17 5 19 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) DNA-replication 4 T2D_r2_98716_1_342_+ FIG00000146 54 9 55 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_98734_265_603_- FIG00009682 6 2 7 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_98738_1_412_+ FIG00002239 14 4 16 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_98792_1_603_- FIG00000365 41 10 43 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_98797_72_603_- FIG00134135 84 15 85 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_98819_1_602_+ FIG00000111 145 24 145 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_98820_1_602_+ FIG00002541 172 24 172 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_98893_1_602_- FIG00001029 19 6 21 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_r2_98951_1_489_- FIG00002332 5 5 8 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_r2_98992_1_602_- FIG00719736 138 22 138 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_99030_1_601_- FIG00044478 97 16 99 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_99066_1_358_+ FIG00000395 10 5 11 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_99069_1_601_- FIG00004568 141 21 142 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Alkanesulfonate assimilation 9.? T2D_r2_99075_1_601_- FIG01955818 70 15 74 Pyruvate:ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_r2_99107_1_482_+ FIG00001528 13 5 14 Cobalt-precorrin-3b C17-methyltransferase Cobalamin synthesis 2 T2D_r2_99117_87_601_- FIG00000288 121 19 122 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_r2_99135_1_601_- FIG01304087 21 5 22 CRISPR-associated helicase Cas3, protein CRISPRs 1 T2D_r2_99207_1_260_+ FIG00000132 57 9 57 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_99240_1_429_- FIG00109688 32 8 33 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_r2_99244_401_601_- FIG00043259 40 7 40 Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18) Inositol catabolism 5.x T2D_r2_99281_1_488_- FIG00001719 50 12 52 Co-activator of prophage gene expression IbrB IbrA and IbrB: co-activators of prophage gene expression 1 T2D_r2_99294_185_600_- FIG00000383 10 3 13 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_r2_99304_1_423_- FIG00000450 35 9 37 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_99341_1_437_+ FIG00010771 118 17 118 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_99389_39_600_+ FIG00033847 55 10 56 Na(+)-translocating NADH-quinone reductase subunit B (EC 1.6.5.-) Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_99407_1_517_- FIG00051439 25 9 27 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_99411_26_600_- FIG00140555 71 13 72 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_99425_1_600_+ FIG00083946 39 14 43 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_99426_275_600_- FIG00003555 12 4 14 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_99427_1_600_- FIG00006463 8 4 10 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_99444_1_558_- FIG00000838 6 3 8 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_99475_1_471_- FIG00073301 124 18 125 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_99518_1_599_- FIG00000380 20 4 23 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_99523_1_529_+ FIG00000043 21 5 23 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_99577_1_599_- FIG00001547 18 6 21 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_99613_1_599_- FIG00437351 49 13 50 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_r2_99641_1_198_+ FIG00000283 7 3 8 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_99681_190_599_+ FIG00000482 41 11 42 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_99698_367_599_- FIG00001548 66 9 66 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_99727_53_598_- FIG00025759 32 8 33 Orotate phosphoribosyltransferase (EC 2.4.2.10) De Novo Pyrimidine Synthesis 1 T2D_r2_99784_1_554_- FIG00000482 55 14 57 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_99829_1_383_- FIG00064110 28 9 30 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_99852_1_598_+ FIG01260980 4 3 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_99857_1_598_- FIG00001029 65 12 66 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_r2_99897_1_314_+ FIG00138258 20 5 22 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_99925_141_320_+ FIG00002574 16 3 17 2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37) Phosphonate metabolism 1 T2D_r2_99978_37_597_+ FIG00059211 47 10 49 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_100026_1_597_+ FIG00077620 27 7 31 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_100027_1_597_+ FIG00006128 137 22 138 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_100052_6_597_- FIG00000793 158 24 158 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_100094_1_597_- FIG00000555 46 13 48 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_100128_1_261_- FIG00004826 22 5 23 L-rhamnose-proton symporter L-rhamnose utilization 1 T2D_r2_100139_1_482_- FIG00002954 47 10 48 Phosphonopyruvate decarboxylase (EC 4.1.1.82) Phosphonate metabolism 1 T2D_r2_100147_1_373_+ FIG00011537 10 3 11 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_100156_1_392_- FIG00007514 50 9 51 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_100165_1_126_+ FIG00000404 26 5 26 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_100174_1_596_- FIG00006953 29 6 31 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_r2_100215_1_596_+ FIG00034293 27 8 29 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_100231_104_596_- FIG00001750 47 7 48 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_100284_72_566_- FIG00000159 58 12 59 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_r2_100301_1_512_+ FIG00000892 30 9 32 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_100320_1_596_- FIG00025216 44 11 45 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_100332_1_596_+ FIG00064110 118 22 118 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_100348_1_596_+ FIG00001547 6 2 9 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_100450_1_595_- FIG00000224 26 9 28 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r2_100498_1_211_+ FIG00001676 53 8 53 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_100536_1_327_+ FIG00000532 82 13 82 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_100657_1_594_- FIG00003086 9 5 10 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_r2_100696_275_594_- FIG00000111 9 4 11 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_100748_454_594_+ FIG00138171 5 3 6 Queuosine biosynthesis QueD, PTPS-I Zinc regulated enzymes 1 T2D_r2_100876_1_439_+ FIG00002561 10 3 12 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_100906_1_593_+ FIG00001307 59 10 62 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_r2_100947_1_580_+ FIG01304195 89 17 90 ABC transporter involved in cytochrome c biogenesis, ATPase component CcmA Biogenesis of c-type cytochromes 1.1 T2D_r2_100973_1_160_- FIG00132994 8 2 8 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_100995_457_593_+ FIG00002328 15 3 16 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_101087_1_592_+ FIG00016110 67 15 68 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_101092_455_592_- FIG00044478 8 2 9 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_101124_1_172_- FIG00000098 7 2 8 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_101138_166_592_+ FIG00000328 98 15 98 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_r2_101210_1_592_- FIG00000503 33 9 35 Cobalt-zinc-cadmium resistance protein CzcD Cobalt-zinc-cadmium resistance 1.26 T2D_r2_101230_1_212_- FIG00024999 35 7 35 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Alkanesulfonate assimilation 9.? T2D_r2_101241_1_337_+ FIG00000198 11 5 12 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_r2_101250_1_592_+ FIG00023943 44 13 47 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_r2_101278_1_354_- FIG00000224 50 8 51 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r2_101286_241_591_- FIG00000402 28 6 29 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_101287_1_591_+ FIG00001088 6 3 9 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_101304_1_591_- FIG00136922 4 2 5 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_101361_1_591_- FIG00034392 64 14 67 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_101378_1_591_- FIG00024930 173 23 173 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_101401_1_200_+ FIG00000309 4 3 6 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_r2_101444_38_591_- FIG00018865 27 9 28 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_101454_254_591_+ FIG00000202 31 7 33 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_101456_1_591_- FIG00052605 55 12 56 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_101468_1_591_- FIG00018699 115 20 116 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_101499_203_591_- FIG00001237 102 15 102 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_r2_101531_1_380_+ FIG00018865 13 6 14 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_101551_1_319_+ FIG00005111 52 10 54 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_r2_101685_1_590_- FIG00002449 7 4 9 Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48) Exopolysaccharide Biosynthesis 1.0 T2D_r2_101704_212_590_+ FIG00000764 15 5 16 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_r2_101728_1_590_- FIG00008230 59 11 60 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_r2_101866_1_589_+ FIG00006691 7 6 10 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_102012_1_235_- FIG00001366 51 8 51 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_r2_102065_1_588_+ FIG00005727 44 11 45 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_102090_24_527_- FIG00000312 5 4 6 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_r2_102099_317_588_+ FIG00001469 10 4 13 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_102105_1_443_- FIG00000532 20 7 23 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_102114_1_588_+ FIG00007960 53 11 55 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_102127_1_127_- FIG00042781 8 3 9 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_102127_145_588_- FIG00017454 45 8 47 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_102301_1_583_+ FIG00475203 14 5 16 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_r2_102302_1_426_+ FIG00000207 51 10 57 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_102313_1_587_- FIG00000825 62 14 90 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_102338_1_587_- FIG00001269 57 13 61 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_102380_13_459_+ FIG00001298 26 5 28 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_102391_1_587_- FIG00000402 36 11 38 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_102393_1_413_- FIG00000011 101 16 101 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_102396_1_587_- FIG00080955 76 18 77 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_102477_1_313_- FIG00004021 16 5 20 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_r2_102495_25_586_- FIG00001065 41 13 43 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_102521_384_586_+ FIG00024401 46 7 46 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_102526_423_586_+ FIG00016514 20 3 21 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_102531_1_586_- FIG00005728 8 4 13 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_r2_102539_363_586_- FIG00073301 6 3 7 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_102545_1_168_- FIG01260980 3 2 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_102563_1_586_- FIG00002300 34 8 35 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_r2_102593_1_494_+ FIG00022300 5 3 9 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_102595_398_586_- FIG00006632 10 3 11 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_r2_102605_1_258_- FIG00002300 54 9 57 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_r2_102627_1_586_- FIG00042616 95 17 97 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_102637_298_586_- FIG00054459 16 6 17 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_102645_1_586_- FIG00000343 23 5 24 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_102682_1_509_+ FIG00000811 38 10 40 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_r2_102733_1_293_+ FIG00000017 17 5 18 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_102733_298_585_+ FIG00000112 24 7 25 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_r2_102734_119_585_+ FIG00000402 109 16 109 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_102764_1_585_+ FIG00000117 108 17 109 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_102775_30_585_- FIG00001280 32 7 35 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_r2_102791_273_585_- FIG00001307 6 4 7 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_r2_102799_1_585_- FIG00001094 61 11 61 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_102818_1_332_- FIG00719736 4 2 7 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_102855_1_174_+ FIG00000146 5 2 6 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_102896_1_585_+ FIG00561498 28 7 30 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_102947_1_585_- FIG00598409 47 12 48 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_r2_102974_1_308_+ FIG01955809 67 11 68 Cytoplasmic copper homeostasis protein cutC Copper homeostasis: copper tolerance 3 T2D_r2_102977_1_201_+ FIG00000211 7 3 8 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_r2_102994_182_584_+ FIG00138031 11 3 12 Iron compound ABC uptake transporter permease protein Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_103018_1_584_+ FIG00017190 153 23 153 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_103033_178_584_+ FIG00138960 105 15 105 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_r2_103053_1_344_- FIG00899307 9 3 10 Monofunctional biosynthetic peptidoglycan transglycosylase (EC 2.4.2.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_103069_1_508_+ FIG00085740 43 10 46 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_103172_1_473_+ FIG00001548 15 6 17 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_103180_1_584_- FIG00719736 57 11 58 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_103212_1_583_+ FIG00003769 14 5 16 Stage III sporulation protein AE Sporulation Cluster III A 1.x T2D_r2_103251_1_583_+ FIG00000381 5 2 7 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_r2_103252_1_583_- FIG00001522 23 8 25 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_r2_103268_271_583_- FIG00121768 72 12 72 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_103306_1_339_- FIG00013534 82 13 84 Substrate-specific component BL0695 of predicted ECF transporter ECF class transporters 345678 T2D_r2_103307_19_583_- FIG00000289 3 3 4 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_103308_1_583_- FIG00052730 6 3 8 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_r2_103348_1_583_+ FIG00010194 54 10 56 Cell wall surface anchor family protein Sortase 1.12 T2D_r2_103350_1_245_- FIG00000036 15 4 16 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_103350_278_583_- FIG00000089 19 6 21 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_r2_103378_1_149_- FIG00846773 17 3 18 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_103381_295_583_- FIG00000147 6 2 8 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_103435_252_582_- FIG00000494 13 5 15 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_103462_333_582_+ FIG00006868 66 10 66 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_r2_103497_1_582_- FIG00034851 103 18 104 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_103498_220_582_- FIG00004058 6 3 7 Aminopeptidase Y (Arg, Lys, Leu preference) (EC 3.4.11.15) EC 3.4.11.- Aminopeptidases 1 T2D_r2_103515_1_582_+ FIG00008591 74 15 76 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_r2_103550_404_582_- FIG00000081 6 2 7 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_103552_1_582_- FIG00000191 38 11 40 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_103559_1_582_+ FIG00000309 66 15 68 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_r2_103587_182_582_- FIG00000450 21 6 22 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_103591_1_406_+ FIG00018699 4 3 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_103609_91_582_- FIG00090765 4 2 9 Lactose and galactose permease, GPH translocator family Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_103612_36_455_- FIG00000219 29 7 30 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_r2_103635_246_582_+ FIG00136692 38 8 39 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_103675_1_581_+ FIG00006128 135 21 137 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_103733_172_339_- FIG00001505 7 3 8 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_103747_432_581_+ FIG00024546 4 2 6 Phosphonoacetaldehyde hydrolase (EC 3.11.1.1) Phosphonate metabolism 1 T2D_r2_103796_348_581_+ FIG00000156 50 8 51 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_103799_1_581_+ FIG00005860 28 8 32 SusD, outer membrane protein Cellulosome 1.x T2D_r2_103848_329_581_+ FIG00000672 8 2 9 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_103851_1_227_- FIG00000422 20 6 22 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_103889_153_580_+ FIG01304818 6 2 8 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_r2_103934_302_580_- FIG00687285 22 5 24 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_r2_103940_1_580_- FIG00002470 21 7 25 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_103957_1_580_- FIG00000117 116 18 117 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_103979_1_580_- FIG00745599 131 20 132 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_r2_104029_1_492_+ FIG00000510 32 7 34 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_r2_104078_370_580_+ FIG00001824 24 5 25 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_104097_1_580_+ FIG00561498 56 14 58 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_104137_1_580_+ FIG00000402 148 23 148 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_104149_1_580_+ FIG00136522 7 5 9 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_r2_104191_1_470_- FIG00001572 114 18 114 Galactitol-1-phosphate 5-dehydrogenase (EC 1.1.1.251) D-Tagatose and Galactitol Utilization 1.x T2D_r2_104230_1_579_+ FIG00132717 12 5 14 ATP-dependent protease La (EC 3.4.21.53) Type II Proteasome bacterial 1 T2D_r2_104247_1_579_+ FIG00001750 44 12 45 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_104276_452_579_- FIG00006632 10 2 11 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_r2_104337_1_503_- FIG00000025 6 2 8 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_104414_160_579_+ FIG00020613 21 6 23 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_r2_104461_398_578_+ FIG00000397 17 4 18 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_r2_104476_13_261_- FIG00000202 29 7 39 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_104503_1_327_- FIG00133325 31 7 33 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_r2_104512_328_578_+ FIG00000283 15 4 16 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_104514_1_269_- FIG00000022 9 3 11 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_r2_104523_1_578_- FIG00019251 5 4 8 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_104532_35_578_+ FIG00000370 130 21 130 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_104564_222_578_- FIG00719736 17 5 18 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_104676_1_360_+ FIG00028461 9 4 10 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_104704_1_577_+ FIG01304601 10 2 11 Exonuclease SbcC DNA repair, bacterial 3 T2D_r2_104756_1_406_+ FIG00013096 41 8 43 Streptococcal cell surface hemoprotein receptor Shr Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_104756_427_577_+ FIG00019881 30 5 30 Cell surface protein Shp, transfers heme from hemoglobin to apo-SiaA/HtsA Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_104778_1_473_+ FIG00000645 81 15 82 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_r2_104787_1_249_+ FIG00000422 28 5 29 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_104805_360_577_- FIG00002689 23 5 24 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_104832_1_177_+ FIG00000482 3 2 4 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_104864_72_416_+ FIG00003251 48 9 50 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_r2_104873_1_577_+ FIG00000539 95 17 97 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_105000_1_156_- FIG00000504 12 2 13 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_105021_1_357_- FIG00000261 81 13 81 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_105085_1_335_+ FIG00002049 66 11 66 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_105089_1_342_+ FIG00000146 18 6 20 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_105108_1_576_+ FIG00132617 40 13 41 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_105123_348_576_+ FIG00001572 6 2 7 Galactitol-1-phosphate 5-dehydrogenase (EC 1.1.1.251) D-Tagatose and Galactitol Utilization 1.x T2D_r2_105150_1_576_+ FIG00006691 5 4 8 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_105156_1_576_- FIG00000069 8 5 9 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_105185_1_568_+ FIG00138538 110 19 111 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_r2_105191_53_514_+ FIG00000892 36 10 38 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_105194_1_575_+ FIG00000402 63 13 64 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_105198_12_575_- FIG01276112 3 3 6 Xylose ABC transporter, permease component Xylose utilization 1 T2D_r2_105285_212_508_+ FIG01583289 16 4 17 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_r2_105288_1_420_- FIG00000402 24 6 25 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_105303_1_575_- FIG00010771 11 6 16 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_105367_1_575_- FIG00000793 32 11 33 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_105372_42_575_- FIG00000241 95 17 96 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_105377_1_575_+ FIG01260980 171 23 171 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_105399_1_463_- FIG00006165 24 6 25 Uracil-DNA glycosylase, family 4 Uracil-DNA glycosylase 1 T2D_r2_105456_47_574_+ FIG00132617 3 4 5 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_105457_203_574_- FIG00005727 7 3 8 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_105486_1_213_- FIG00000140 46 8 46 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_105497_1_265_- FIG00000017 73 10 73 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_105497_400_574_- FIG00000531 27 5 29 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_105513_1_574_- FIG00012683 8 6 24 NLP/P60 family protein CBSS-393121.3.peg.2760 1 T2D_r2_105549_1_574_- FIG00000395 25 6 27 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_105560_1_273_+ FIG00133325 24 5 25 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_r2_105598_1_256_+ FIG00000986 22 5 22 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_r2_105598_266_574_+ FIG00133196 15 5 17 L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-) L-ascorbate utilization (and related gene clusters) 29 T2D_r2_105614_1_574_- FIG00018457 7 4 8 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_105666_1_426_- FIG00001264 4 2 6 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_105687_54_371_+ FIG00077620 5 2 6 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_105690_1_573_+ FIG01260980 5 3 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_105697_1_290_- FIG00013339 21 6 23 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_105730_1_573_+ FIG00002385 157 22 158 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_105735_1_573_- FIG00473043 31 11 36 Similar to CDP-glucose 4,6-dehydratase (EC 4.2.1.45) Acetoin, butanediol metabolism 5 T2D_r2_105804_1_389_+ FIG00000487 32 8 33 ATP-dependent protease HslV (EC 3.4.25.-) Proteasome bacterial 1 T2D_r2_105819_1_413_+ FIG00009194 4 2 6 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_105821_41_573_- FIG00033206 13 5 15 Enoyl-CoA hydratase (EC 4.2.1.17) Polyhydroxybutyrate metabolism 5.6 T2D_r2_105860_29_573_- FIG00207095 111 19 111 Membrane fusion protein of RND family multidrug efflux pump Multidrug Resistance Efflux Pumps 1.12 T2D_r2_105919_1_256_+ FIG01016270 24 5 25 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_r2_106004_172_572_+ FIG00001384 4 2 6 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_106034_1_572_- FIG00018699 153 22 153 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_106062_1_572_+ FIG00000474 17 6 18 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_r2_106111_1_181_- FIG00000282 23 4 24 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_106135_1_572_+ FIG00034293 3 3 5 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_106138_243_572_+ FIG00000036 53 9 54 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_106146_1_260_- FIG00000085 17 4 18 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_106154_208_572_+ FIG00002020 4 3 6 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_106155_1_572_- FIG00025216 9 6 11 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_106160_1_572_+ FIG00000601 57 16 59 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_106192_1_572_+ FIG00000520 20 4 22 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_106252_1_454_- FIG00003090 100 16 100 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_r2_106260_1_571_+ FIG00022300 71 14 72 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_106277_1_571_+ FIG00000673 45 10 47 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_r2_106349_1_571_+ FIG00134889 60 14 61 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_106370_1_571_+ FIG00001036 131 21 132 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_r2_106373_198_571_+ FIG00000391 99 14 99 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_r2_106376_1_519_+ FIG00001065 15 6 18 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_106404_1_571_+ FIG00132617 120 20 121 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_106409_1_571_+ FIG00039969 5 2 7 CRISPR-associated protein, Csm5 family CRISPR-associated cluster 1 T2D_r2_106421_1_571_+ FIG00028461 50 12 55 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_106433_1_571_+ FIG00000380 41 8 43 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_106437_1_571_- FIG00000464 26 8 28 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_106456_1_570_- FIG00000011 13 4 15 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_106457_1_242_- FIG00846773 3 2 4 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_106457_315_570_- FIG00041038 26 6 28 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_106501_1_570_- FIG00000681 3 4 5 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_r2_106565_1_570_- FIG00138182 158 22 158 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_r2_106635_1_139_- FIG00000450 5 2 6 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_106681_1_270_+ FIG00001569 3 2 4 LysR family regulatory protein CidR Murein hydrolase regulation and cell death 1.2 T2D_r2_106689_1_570_- FIG00002161 106 18 107 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_r2_106718_128_569_+ FIG00000396 94 16 94 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_r2_106864_48_569_- FIG01304860 118 19 119 [Ni/Fe] hydrogenase, group 1, small subunit Hydrogenases 2 T2D_r2_106878_1_340_- FIG00129616 34 9 36 GTP-binding protein EngA Universal GTPases 2 T2D_r2_106881_46_569_- FIG00000047 47 12 49 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_106917_1_569_+ FIG00004763 42 11 44 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_106925_1_569_- FIG00000838 138 21 138 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_106951_27_197_+ FIG00451095 5 3 8 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_106956_191_568_- FIG00013554 98 14 98 Stage III sporulation protein AB Sporulation Cluster III A 1.x T2D_r2_106987_154_537_+ FIG00014760 6 3 8 Dimeric dUTPase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_106989_1_568_- FIG00006279 13 11 59 LysR family transcriptional regulator YhjC DNA-binding regulatory proteins, strays 1 T2D_r2_106999_1_394_+ FIG00073301 30 6 31 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_107005_1_298_- FIG00132770 4 2 5 Prephenate and/or arogenate dehydrogenase (unknown specificity) (EC 1.3.1.12)(EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_r2_107027_90_568_+ FIG00000101 39 12 41 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_r2_107055_1_568_+ FIG00000025 19 6 20 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_107072_1_568_+ FIG00002344 24 8 26 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r2_107096_1_381_- FIG00000487 21 7 23 ATP-dependent protease HslV (EC 3.4.25.-) Proteasome bacterial 1 T2D_r2_107146_21_568_+ FIG00000539 57 12 58 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_107229_50_567_- FIG00000085 5 3 7 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_107246_144_567_+ FIG01290653 3 3 5 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_107253_1_567_- FIG00051001 4 3 7 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Biotin biosynthesis 1X T2D_r2_107269_344_567_+ FIG00000343 49 8 49 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_107271_1_441_+ FIG00006551 36 10 37 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_107338_1_384_- FIG00134135 97 14 98 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_107371_1_567_- FIG00455853 18 8 21 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_107373_1_567_- FIG00000308 58 13 59 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_r2_107387_1_567_+ FIG00041382 19 7 20 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_107409_47_567_- FIG00000235 39 10 40 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_107419_1_567_+ FIG00006151 18 4 20 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_107525_1_238_- FIG00000323 30 7 31 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_107557_216_566_- FIG00035627 89 13 90 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_107561_1_437_+ FIG00001675 49 11 50 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_107598_1_566_+ FIG00000372 9 8 20 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_107670_19_566_+ FIG00052605 141 21 142 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_107719_337_566_- FIG00000260 9 2 10 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_107721_1_566_+ FIG00041038 45 13 46 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_107785_1_565_- FIG00000234 86 18 88 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_107812_1_353_+ FIG00000467 36 7 38 Biotin synthase (EC 2.8.1.6) Biotin biosynthesis 1X T2D_r2_107916_1_165_+ FIG00037431 11 3 13 DNA repair protein RadC DNA repair, bacterial 3 T2D_r2_107970_1_565_- FIG00130344 41 9 43 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_107998_73_565_+ FIG00002914 3 3 9 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_108027_1_564_+ FIG00003788 17 6 19 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_108042_1_564_+ FIG00135469 151 21 152 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_r2_108092_43_564_- FIG00002239 8 4 9 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_108124_240_564_+ FIG00023946 8 2 9 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_108126_1_564_+ FIG00000401 139 22 140 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_108134_1_564_+ FIG00059211 14 3 16 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_108188_1_564_+ FIG00001385 6 4 8 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_108189_146_448_+ FIG00000777 8 3 10 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_108246_1_564_- FIG00067248 14 6 16 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_108279_1_430_- FIG00009682 38 8 40 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_108304_81_440_+ FIG00001802 90 14 90 FIG001802: Putative alkaline-shock protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_108341_277_563_- FIG00010454 5 4 7 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_108361_1_563_- FIG00010454 60 12 61 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_108473_1_336_+ FIG00032749 50 10 51 Protein YicC CBSS-323097.3.peg.2594 1 T2D_r2_108503_117_563_+ FIG00000245 76 12 76 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_108515_1_456_+ FIG00000118 125 18 125 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_r2_108521_1_563_+ FIG00000717 110 19 111 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_r2_108539_1_562_+ FIG00000070 30 9 31 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_108560_1_562_+ FIG00000043 11 7 13 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_108593_242_562_- FIG00000132 73 11 73 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_108597_1_562_+ FIG00136193 8 2 10 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_r2_108616_1_562_+ FIG00016132 4 3 9 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_r2_108622_304_562_+ FIG00126843 51 8 52 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_108624_1_486_+ FIG00000494 15 4 16 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_108677_1_562_+ FIG00038611 113 20 113 Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_r2_108704_1_562_+ FIG00004078 151 22 151 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_108768_1_562_+ FIG00075702 43 13 44 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_108785_1_216_+ FIG00002231 52 8 52 Membrane-bound lytic murein transglycosylase A precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_r2_108786_1_448_- FIG00004170 125 18 125 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_r2_108789_1_470_- FIG00034851 15 6 17 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_108871_1_561_+ FIG00138258 78 17 80 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_108877_90_464_- FIG00008572 10 4 11 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_r2_108919_1_196_+ FIG00004453 8 3 9 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_r2_108922_1_133_+ FIG00561498 11 2 12 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_108923_286_561_+ FIG00006386 13 3 15 Phage minor tail protein Phage tail proteins 2 4 T2D_r2_108957_1_161_- FIG00023985 28 5 28 ABC transporter involved in cytochrome c biogenesis, CcmB subunit Biogenesis of c-type cytochromes 1.1 T2D_r2_108957_200_561_- FIG01304195 80 13 80 ABC transporter involved in cytochrome c biogenesis, ATPase component CcmA Biogenesis of c-type cytochromes 1.1 T2D_r2_108967_1_281_- FIG00229386 11 5 12 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_108990_1_561_- FIG00229386 140 22 140 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_109046_1_291_+ FIG00000474 46 8 48 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_r2_109058_119_561_+ FIG00000933 73 14 74 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_r2_109066_1_561_- FIG00000241 127 21 127 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_109081_1_235_- FIG00000312 56 8 57 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_r2_109097_106_357_+ FIG00000189 70 10 70 LSU ribosomal protein L27p CBSS-176279.3.peg.868 1.x T2D_r2_109120_1_347_- FIG00016110 86 13 86 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_109187_1_560_+ FIG00000822 19 7 20 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_r2_109197_249_551_+ FIG00003012 62 11 62 His repressor CBSS-393121.3.peg.1913 1 T2D_r2_109207_284_560_+ FIG00000539 69 11 69 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_109211_1_560_+ FIG00000441 35 9 38 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_109254_119_560_- FIG00405688 25 6 27 Teichuronic acid biosynthesis protein TuaE, putative secreted polysaccharide polymerase Teichuronic acid biosynthesis 9 T2D_r2_109263_1_560_+ FIG00001548 7 4 9 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_109307_1_560_- FIG00000422 65 14 66 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_109321_1_560_+ FIG01956356 63 14 64 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_r2_109345_1_560_+ FIG00001104 50 12 52 Arginine deiminase (EC 3.5.3.6) Arginine and Ornithine Degradation 1.34 T2D_r2_109391_1_545_+ FIG00000288 14 6 16 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_r2_109414_1_477_+ FIG00133569 41 8 42 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_r2_109483_134_559_+ FIG00009682 6 5 15 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_109517_1_559_+ FIG00002742 13 5 16 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_109523_1_559_- FIG00132617 53 12 54 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_109599_1_559_- FIG00041038 67 14 68 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_109603_1_559_- FIG00000130 52 11 54 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_109610_1_436_+ FIG00000224 14 4 15 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r2_109662_1_558_+ FIG00037273 110 17 111 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_r2_109678_1_308_- FIG00040817 20 5 21 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_109682_1_310_+ FIG00024401 8 2 9 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_109689_1_183_+ FIG00008941 9 2 10 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_109704_1_558_+ FIG00007941 11 3 13 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_r2_109739_223_558_- FIG00000531 36 8 38 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_109758_1_417_- FIG00001843 110 16 110 Phage tail sheath monomer Phage tail proteins 2 4 T2D_r2_109819_1_558_- FIG00058830 140 21 141 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_109836_1_413_+ FIG00139192 28 8 29 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_r2_109846_1_558_- FIG00000243 10 5 12 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_109948_1_557_- FIG00041382 164 22 164 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_109968_91_540_+ FIG00000720 55 11 57 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_r2_110046_1_449_+ FIG00011659 10 4 13 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_r2_110048_1_557_- FIG00000448 6 4 8 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_110077_172_557_- FIG00005992 6 2 7 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_110104_318_557_+ FIG00000756 22 5 23 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_r2_110111_1_519_- FIG00024930 10 3 12 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_110138_1_557_+ FIG00060517 23 7 24 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_110164_1_475_+ FIG00000011 11 7 23 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_110206_174_556_+ FIG00000309 21 7 24 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_r2_110211_1_556_+ FIG00016110 70 14 74 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_110222_1_533_- FIG00000013 3 3 5 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_110239_381_556_+ FIG00000263 21 5 22 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_110254_1_443_- FIG00000263 109 17 109 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_110293_1_423_+ FIG00000134 93 14 93 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_110323_1_259_- FIG00058830 23 5 26 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_110337_1_237_- FIG00554193 7 2 8 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_110373_1_556_+ FIG01260980 11 5 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_110423_1_556_- FIG00001548 21 5 23 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_110491_1_225_+ FIG00011537 41 7 41 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_110501_1_555_- FIG00034851 24 7 26 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_110551_1_555_- FIG00010738 33 9 35 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_r2_110578_1_458_- FIG00000147 31 8 33 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_110581_1_555_+ FIG00047056 10 3 11 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_r2_110641_1_555_+ FIG00000279 109 20 110 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_110677_1_127_- FIG00001747 6 3 6 Putative metallopeptidase (Zinc) SprT family CBSS-393131.3.peg.612 1 T2D_r2_110683_1_268_+ FIG00001582 17 3 18 Putative Nudix hydrolase YfcD (EC 3.6.-.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_110685_340_555_+ FIG00001253 10 3 11 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_r2_110752_1_554_+ FIG00001675 21 8 23 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_110770_1_548_+ FIG00130344 23 8 25 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_110786_1_269_+ FIG00000645 7 2 8 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_r2_110876_125_554_- FIG00000967 63 11 64 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_r2_110906_1_157_+ FIG00064110 10 3 11 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_110915_1_156_+ FIG00000242 10 2 11 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_110934_1_152_- FIG00000584 31 5 31 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_110937_1_554_- FIG00035634 150 21 150 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_r2_110975_1_554_+ FIG00074225 27 6 28 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_110986_1_373_+ FIG00007960 86 14 86 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_111013_1_553_+ FIG00000333 27 8 28 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_111041_177_553_+ FIG00000459 35 8 37 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_111130_1_553_- FIG00052605 26 6 27 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_111167_1_341_- FIG00000441 8 3 9 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_111212_1_553_+ FIG00001562 7 4 10 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_r2_111312_1_306_+ FIG00000132 16 5 17 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_111312_353_552_+ FIG00000132 4 3 5 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_111352_1_552_- FIG00000146 102 17 118 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_111382_1_552_- FIG00000402 46 10 48 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_111387_104_552_+ FIG00000130 13 6 16 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_111408_1_552_- FIG00134889 72 15 73 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_111432_1_552_- FIG00011537 14 6 17 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_111443_198_552_+ FIG00007694 9 3 11 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_r2_111453_1_509_- FIG00000301 72 15 75 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_r2_111484_1_552_+ FIG00080099 24 7 25 Beta-glucanase precursor (EC 3.2.1.73) Beta-Glucoside Metabolism 2.bc T2D_r2_111556_47_552_+ FIG00000069 71 15 72 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_111609_1_277_- FIG00138468 57 10 57 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_111641_1_490_+ FIG00022300 41 13 48 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_111656_1_551_+ FIG00028461 21 7 23 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_111671_1_551_+ FIG00009194 33 5 34 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_111726_1_551_+ FIG00000151 39 10 40 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_r2_111739_1_551_+ FIG00000111 29 7 31 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_111794_1_551_+ FIG00001385 9 3 10 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_111798_114_551_- FIG01260980 120 16 120 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_111829_1_551_- FIG00005022 20 4 22 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_111836_169_551_- FIG00132617 54 10 55 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_111882_35_550_- FIG00001067 138 20 138 Rubrerythrin Oxidative stress 1.2 T2D_r2_111893_220_550_+ FIG00013525 28 8 30 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_r2_111969_410_550_- FIG00001020 3 2 4 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_111974_1_403_+ FIG00139238 4 3 8 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_r2_112063_1_550_- FIG00121768 45 8 47 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_112073_1_193_+ FIG00001552 3 3 4 S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1B Polyamine Metabolism 2 T2D_r2_112075_101_550_- FIG00000531 40 10 41 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_112090_1_550_- FIG00018369 112 17 113 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_112136_1_428_+ FIG00000184 9 3 13 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_112159_1_549_+ FIG00093180 20 10 22 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_112190_1_549_+ FIG00094401 147 22 147 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_112204_1_437_- FIG00017190 8 3 9 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_112219_1_363_+ FIG00000476 46 7 47 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_112304_1_470_- FIG00000140 53 11 56 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_112319_1_549_+ FIG00002020 155 21 155 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_112373_1_549_- FIG00000446 38 10 39 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_112423_1_549_- FIG00035175 14 7 15 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_112434_295_548_+ FIG00001209 9 3 10 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_112441_1_548_+ FIG00000356 34 8 36 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_112473_1_548_- FIG00000011 24 9 26 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_112474_1_548_+ FIG00018699 114 19 116 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_112546_1_548_+ FIG00000351 16 8 18 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_r2_112554_1_548_- FIG00075702 75 16 77 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_112555_396_548_- FIG00011987 10 2 11 Stage III sporulation protein AD Sporulation Cluster III A 1.x T2D_r2_112618_1_548_+ FIG00002541 151 21 151 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_112622_369_548_+ FIG00003845 42 7 42 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_r2_112638_330_548_- FIG00000421 18 4 19 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_r2_112667_98_548_- FIG00003176 23 7 24 Pyruvate:ferredoxin oxidoreductase, gamma subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_r2_112695_1_548_- FIG00003555 14 6 15 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_112709_340_548_+ FIG00002022 18 5 20 Nucleotide excision repair protein, with UvrB/UvrC motif Proteolysis in bacteria, ATP-dependent 3 T2D_r2_112728_1_192_- FIG00031250 11 3 12 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_112728_195_548_- FIG00000445 61 11 62 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_r2_112730_1_548_+ FIG00000372 53 10 54 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_112765_141_547_- FIG00000011 99 15 99 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_112772_328_547_- FIG00032196 25 6 26 Formate hydrogenlyase transcriptional activator Formate hydrogenase 3.1?? T2D_r2_112825_161_547_+ FIG00022899 10 3 11 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_112836_1_367_+ FIG00000491 65 12 67 Queuosine Biosynthesis QueC ATPase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_112856_1_547_+ FIG00000822 9 5 12 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_r2_112859_1_547_- FIG00000118 144 21 144 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_r2_112866_1_547_- FIG00007957 84 16 87 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_112928_1_547_- FIG00041382 32 8 33 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_112954_1_547_+ FIG00031250 39 9 40 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_112979_121_547_- FIG00719736 76 13 78 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_112990_22_547_+ FIG00229386 24 7 27 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_112992_41_547_- FIG00000011 16 6 17 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_113030_1_547_+ FIG00000538 149 22 149 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_r2_113112_1_139_- FIG00006691 26 4 27 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_113197_1_546_- FIG00000268 79 16 80 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_113259_1_546_+ FIG00009682 89 17 90 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_113277_339_546_- FIG00000341 41 7 41 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_113288_1_546_- FIG00000102 51 12 53 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_113378_72_545_+ FIG00125395 31 8 32 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_113386_1_545_- FIG00000578 83 15 106 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_113394_1_545_+ FIG00002130 13 4 14 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_113422_237_491_- FIG00000185 40 7 41 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_113463_1_545_- FIG00000402 63 15 65 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_113552_26_545_- FIG00001328 132 21 132 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_r2_113581_229_545_+ FIG00020897 76 11 76 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_r2_113593_1_336_- FIG01010650 74 12 74 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_113641_1_544_- FIG00044622 58 9 59 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_113649_62_421_- FIG00229216 69 10 70 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_113658_1_426_+ FIG00044622 61 11 62 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_113679_1_544_+ FIG00088067 24 7 26 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_r2_113716_1_544_- FIG00000191 5 2 6 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_113722_109_544_+ FIG00001188 6 3 7 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_r2_113757_1_544_- FIG00028203 68 16 70 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_113824_2_544_- FIG01954109 3 2 4 D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30) Polyhydroxybutyrate metabolism 5.6 T2D_r2_113861_1_544_+ FIG00451095 126 19 128 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_113895_1_310_- FIG00000101 24 6 26 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_r2_113903_1_171_+ FIG00000383 9 3 12 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_r2_113903_233_544_+ FIG00001168 7 3 8 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_113904_1_451_+ FIG00021517 4 3 6 Cell division protein FtsQ Cell Division Cluster 1.x T2D_r2_114001_1_146_- 7 2 8 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_r2_114036_1_543_- FIG00016768 10 4 12 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_114130_1_486_+ FIG00001022 9 4 10 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_114131_1_528_+ FIG00644514 34 7 36 Putative cytochrome C-type biogenesis protein Biogenesis of c-type cytochromes 1.1 T2D_r2_114163_1_543_- FIG00000402 35 12 38 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_114180_376_543_- FIG00519009 26 5 26 Hexokinase (EC 2.7.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_114183_1_163_+ FIG00000282 15 3 16 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_114196_1_258_+ FIG00000065 77 10 77 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_114243_1_542_+ FIG00001054 6 4 12 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_114246_338_542_+ FIG00041382 52 8 52 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_114340_1_542_+ FIG00018536 20 7 24 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_114347_1_542_- FIG00001902 102 16 103 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_114353_325_542_+ FIG00001676 14 5 15 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_114415_370_542_+ FIG00000198 32 6 32 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_r2_114416_1_497_+ FIG00003881 30 8 31 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_r2_114441_1_542_+ FIG00001547 10 3 12 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_114466_146_542_- FIG00001491 49 10 50 Peroxide stress regulator PerR, FUR family Oxidative stress 1.2 T2D_r2_114509_1_230_- FIG00000234 8 3 9 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_114515_1_459_+ FIG00000695 56 13 58 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_114528_1_222_+ FIG00004764 27 7 29 Ammonium transporter Ammonia assimilation 1 T2D_r2_114528_269_541_+ FIG00005111 58 9 59 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_r2_114543_1_541_+ FIG01954097 25 5 27 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_114561_1_168_- FIG01292786 19 3 20 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_r2_114587_1_541_- FIG00001932 41 10 42 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_114591_1_519_+ FIG00061832 90 16 91 Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) Sialic Acid Metabolism 1.x T2D_r2_114611_1_541_+ FIG00001129 28 9 32 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_r2_114622_1_541_- FIG00000721 12 6 13 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_114627_1_541_- FIG00136692 71 15 73 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_114637_160_541_+ FIG00003460 89 14 89 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_114656_150_473_+ FIG00001862 7 2 8 L-rhamnose mutarotase L-rhamnose utilization 1 T2D_r2_114707_272_541_+ FIG00007079 14 5 16 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_114715_1_541_+ FIG00001209 30 10 34 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_114734_1_541_+ FIG01961758 105 17 106 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_r2_114847_337_540_- FIG00077620 15 3 17 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_114881_1_540_- FIG00001530 13 6 15 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_r2_114907_1_540_- FIG00001440 71 14 72 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_114927_1_174_+ FIG01312219 45 7 45 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_r2_114927_244_540_+ FIG00003580 71 11 71 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_114954_1_484_+ FIG00023943 14 4 16 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_r2_114978_255_540_- FIG00001902 15 4 16 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_114998_1_540_- FIG00001237 7 3 8 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_r2_115012_1_297_+ FIG00018699 77 11 77 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_115012_349_540_+ FIG00002255 30 6 30 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) Polyhydroxybutyrate metabolism 5.6 T2D_r2_115079_1_528_+ FIG00000381 4 6 12 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_r2_115084_1_539_- FIG00006092 105 19 106 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_115100_1_206_- FIG00000157 12 4 14 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_115133_1_539_+ FIG00012945 8 3 10 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_115156_1_539_+ FIG00000773 12 4 20 Glutamyl-tRNA synthetase (EC 6.1.1.17) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_115178_143_539_- FIG01260980 113 15 113 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_115179_309_539_- FIG00026918 17 4 18 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_115208_1_539_+ FIG00000782 104 16 112 Exonuclease SbcD DNA repair, bacterial 3 T2D_r2_115227_1_539_+ FIG00073301 8 3 10 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_115228_307_539_+ FIG00043259 4 2 5 Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18) Inositol catabolism 5.x T2D_r2_115247_294_539_- FIG01955809 22 5 23 Cytoplasmic copper homeostasis protein cutC Copper homeostasis: copper tolerance 3 T2D_r2_115288_278_539_+ FIG00001022 32 6 33 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_115316_1_295_+ FIG00000146 7 2 9 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_115318_1_539_+ FIG00041038 80 17 81 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_115330_1_539_- FIG00000032 140 21 140 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_115386_1_293_- FIG00117785 11 3 14 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_r2_115448_1_538_+ FIG00000343 104 17 105 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_115567_395_538_+ FIG00004078 28 5 28 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_115624_1_538_- FIG00451095 7 3 8 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_115654_1_538_+ FIG00000283 38 10 40 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_115760_1_537_+ FIG00132787 36 9 38 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_r2_115765_1_537_+ FIG00001292 125 18 126 D-alanine aminotransferase (EC 2.6.1.21) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_115790_1_537_- FIG00846773 22 6 25 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_116039_1_297_+ FIG00145509 18 3 20 Glutamate synthase, alpha subunit domain protein Ammonia assimilation 1 T2D_r2_116039_319_536_+ FIG00134889 31 5 32 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_116049_152_536_+ FIG00000047 40 9 41 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_116073_91_536_+ FIG00001020 28 9 30 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_116106_1_536_+ FIG00229386 24 9 25 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_116142_297_536_- FIG00000098 58 8 59 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_116226_1_168_- FIG00009038 8 3 9 D,D-heptose 7-phosphate kinase Capsular heptose biosynthesis 1 T2D_r2_116269_104_536_- FIG01304329 104 16 104 Chromosome (plasmid) partitioning protein ParA Cell Division Subsystem including YidCD 1 T2D_r2_116332_1_436_+ FIG00000244 124 17 124 Ketol-acid reductoisomerase (EC 1.1.1.86) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_116336_1_271_- FIG00077620 7 4 8 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_116391_1_535_- FIG00018392 20 6 28 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_r2_116401_1_224_- FIG00001067 18 4 19 Rubrerythrin Oxidative stress 1.2 T2D_r2_116407_1_504_+ FIG00028203 39 11 40 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_116428_1_392_- FIG00000022 76 13 77 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_r2_116493_9_535_- FIG00000370 6 4 8 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_116553_1_535_- FIG00001537 91 17 113 Cytochrome c552 precursor (EC 1.7.2.2) Nitrate and nitrite ammonification 1 T2D_r2_116566_290_535_- FIG00000621 11 3 12 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_116581_1_320_+ FIG00004843 46 7 47 Protein YidD Cell Division Subsystem including YidCD 1 T2D_r2_116650_1_534_- FIG00004021 145 20 145 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_r2_116687_1_162_- FIG00000148 41 6 41 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_r2_116711_1_534_+ FIG00001932 138 21 138 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_116739_287_534_+ FIG00048014 19 5 30 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_116740_1_534_+ FIG00067681 52 8 53 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_116799_1_443_- FIG00021289 4 3 5 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_116807_1_534_+ FIG00011468 42 9 43 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_r2_116836_1_422_+ FIG00000365 36 8 37 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_116849_1_534_- FIG00000555 4 3 5 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_116916_1_534_- FIG00002130 12 6 19 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_116917_1_534_- FIG01304087 11 3 12 CRISPR-associated helicase Cas3, protein CRISPRs 1 T2D_r2_116962_77_534_- FIG00001175 7 2 8 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_116974_1_165_- FIG00001182 39 6 39 [NiFe] hydrogenase nickel incorporation protein HypA NiFe hydrogenase maturation 1 T2D_r2_116991_1_533_- FIG00016132 9 5 11 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_r2_117037_1_533_+ FIG00003788 8 4 15 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_117067_1_279_+ FIG00001676 72 10 72 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_117074_223_533_- FIG00002332 4 2 5 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_r2_117111_152_469_+ FIG00003270 46 7 47 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_r2_117122_228_533_- FIG00000442 9 4 10 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_117127_1_249_+ FIG00136692 22 5 23 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_117127_269_533_+ FIG00000433 30 6 31 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_117159_99_533_+ FIG00000463 117 17 117 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_r2_117173_1_533_+ FIG00008778 47 11 48 Maltose operon transcriptional repressor MalR, LacI family Maltose and Maltodextrin Utilization 1.x T2D_r2_117180_1_533_+ FIG00000372 33 8 34 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_117197_384_533_- FIG00000151 3 3 4 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_r2_117216_1_215_+ FIG00038920 11 5 12 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_r2_117308_1_421_- FIG00000372 16 6 19 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_117313_1_532_+ FIG00000654 151 21 151 tolB protein precursor, periplasmic protein involved in the tonb-independent uptake of group A colicins Ton and Tol transport systems 2 T2D_r2_117342_1_532_- FIG00132839 80 15 81 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_117351_1_532_+ FIG00041038 46 13 48 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_117369_21_532_+ FIG00001676 25 6 27 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_117399_1_279_- FIG00000268 24 7 50 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_117469_137_532_- FIG00066643 23 6 24 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_117526_1_532_- FIG00003433 20 6 22 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_r2_117602_353_532_+ FIG00038611 15 4 16 Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_r2_117624_1_503_+ FIG00000333 106 17 106 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_117650_1_286_- FIG00011537 59 9 59 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_117658_1_385_+ FIG00011537 9 2 10 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_117671_1_531_+ FIG00004763 132 20 132 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_117715_5_531_+ FIG01239241 12 5 14 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_r2_117750_1_531_- FIG00052300 12 4 15 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_117791_1_233_- FIG00004169 14 3 15 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_117804_303_531_+ FIG00000494 6 3 7 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_117807_1_531_- FIG00000185 85 14 86 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_117816_1_531_+ FIG00045393 109 19 109 Dipeptide transport ATP-binding protein DppF (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_117830_1_531_- FIG00000539 21 4 24 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_117842_1_433_- FIG00000075 6 3 8 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_r2_117848_1_139_+ FIG00207095 29 5 29 Membrane fusion protein of RND family multidrug efflux pump Multidrug Resistance Efflux Pumps 1.12 T2D_r2_117848_156_531_+ FIG00034851 89 14 89 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_117896_1_158_- FIG00000258 20 5 21 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_r2_117896_195_531_- FIG00044478 17 5 18 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_117907_333_531_+ FIG00054459 6 3 7 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_117947_369_530_- FIG00000211 6 2 7 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_r2_117956_1_530_- FIG00041038 40 11 42 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_117984_1_528_+ FIG00016663 142 21 142 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_118067_1_530_- FIG00000283 65 12 67 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_118075_1_154_+ FIG00000053 11 3 11 LSU ribosomal protein L33p Ribosome LSU bacterial 9 T2D_r2_118100_1_530_+ FIG00000380 8 2 10 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_118150_150_530_- FIG00000367 89 14 89 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_r2_118205_1_515_+ FIG00001518 122 19 123 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_r2_118230_1_362_- FIG00000352 48 9 49 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r2_118237_1_308_+ FIG00002049 32 7 33 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_118263_1_529_+ FIG00001537 111 16 112 Cytochrome c552 precursor (EC 1.7.2.2) Nitrate and nitrite ammonification 1 T2D_r2_118279_1_529_- FIG00000582 20 7 21 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_118315_287_529_- FIG00055715 9 4 11 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_118335_1_529_- FIG00007957 21 5 23 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_118366_1_529_- FIG00000146 106 19 107 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_118437_1_529_+ FIG00036983 21 7 24 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_118496_1_430_+ FIG00002974 4 3 9 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_r2_118555_343_528_+ FIG00000356 41 7 41 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_118574_1_140_- FIG00000266 7 3 9 LSU ribosomal protein L28p A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_118594_1_528_- FIG00002020 15 5 17 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_118615_82_528_- FIG00002289 4 3 6 Soluble lytic murein transglycosylase precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_r2_118639_1_528_- FIG00052730 10 5 11 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_r2_118692_183_506_+ FIG00001834 85 12 85 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_118795_1_528_- FIG01304818 74 14 97 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_r2_118862_1_388_- FIG00002414 6 2 8 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_r2_118871_1_508_+ FIG00000721 4 3 6 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_118902_1_527_- FIG00000107 58 14 60 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_r2_118919_1_527_- FIG00132666 19 7 20 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_118931_1_527_+ FIG00007957 76 16 77 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_119051_3_464_- FIG00000720 22 5 24 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_r2_119145_220_527_+ FIG00003086 39 7 41 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_r2_119220_1_169_- FIG01954097 42 6 42 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_119259_1_526_- FIG00011537 24 6 25 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_119282_122_526_- FIG00002553 109 16 109 Starvation sensing protein RspA Carbon Starvation 1.21 T2D_r2_119301_1_526_+ FIG00051439 18 5 20 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_119319_1_157_- FIG00001011 6 3 7 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_r2_119323_1_255_+ FIG00000840 10 3 11 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_r2_119439_1_526_- FIG00028461 53 12 54 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_119475_1_526_+ FIG00006463 109 19 110 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_119525_1_200_- FIG00086697 39 7 39 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_r2_119531_230_526_+ FIG01007502 61 10 62 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_119553_368_525_- FIG00006032 9 2 9 Cobalamin synthase Cobalamin synthesis 2 T2D_r2_119591_268_525_- FIG00000258 13 4 15 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_r2_119606_1_525_- FIG00000482 37 9 39 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_119615_1_374_- FIG00000377 92 14 92 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_119621_286_525_- FIG00000402 34 6 35 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_119624_1_525_- FIG00451095 137 20 138 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_119693_1_525_- FIG00001548 3 2 6 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_119697_1_326_- FIG01280345 4 2 5 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_r2_119707_1_414_- FIG00000555 19 4 21 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_119712_1_525_- FIG00132801 9 2 11 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_r2_119715_111_525_+ FIG00001065 28 9 29 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_119758_1_335_- FIG00003472 25 7 26 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_119799_1_525_+ FIG00025216 18 6 19 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_119896_194_524_+ FIG00000166 76 13 76 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_r2_119929_1_524_+ FIG00001067 131 20 131 Rubrerythrin Oxidative stress 1.2 T2D_r2_119955_1_236_+ FIG01318274 8 3 9 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_119983_1_524_+ FIG00229386 8 6 18 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_120000_1_524_- FIG00067681 72 14 73 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_120019_159_524_- FIG00002049 25 8 26 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_120092_1_524_+ FIG00014079 78 12 79 HipA protein Persister Cells 1 T2D_r2_120112_1_516_+ FIG00000168 41 8 42 Transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_120131_1_407_- FIG01304818 100 15 100 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_r2_120169_1_524_+ FIG00012267 3 2 5 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_r2_120200_240_523_+ FIG00000146 53 9 54 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_120209_1_508_+ FIG00041038 28 7 29 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_120224_1_523_- FIG00006463 58 11 61 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_120306_1_523_+ FIG00008907 10 5 13 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_r2_120343_1_523_+ FIG00000043 57 12 58 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_120369_213_523_+ FIG00149566 64 11 64 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_120397_1_523_+ FIG00003435 55 12 57 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_120467_1_523_- FIG00047414 15 7 21 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_120476_1_523_+ FIG00017615 80 12 81 Universal stress protein family Universal stress protein family 1 T2D_r2_120503_1_522_+ FIG00561498 91 18 92 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_120534_1_522_+ FIG00012067 31 7 33 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_r2_120594_1_492_+ FIG00132994 134 19 134 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_120603_1_440_- FIG00000088 15 4 17 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_120653_1_192_- FIG00000263 47 7 47 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_120669_340_522_- FIG00001132 14 3 15 LSU ribosomal protein L16p (L10e) Ribosome LSU bacterial 9 T2D_r2_120670_1_522_- FIG00000287 50 10 52 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_120672_1_522_+ FIG00066575 20 7 22 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_120733_1_522_+ FIG00066643 22 6 24 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_120741_1_205_+ FIG00008591 6 2 7 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_r2_120777_384_522_+ FIG00001819 7 2 8 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_r2_120788_1_230_- FIG00000134 11 5 12 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_120866_20_521_+ FIG00001407 5 4 7 FKBP-type peptidyl-prolyl cis-trans isomerase fklB (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_r2_120893_1_521_- FIG00002008 13 5 18 Allantoinase (EC 3.5.2.5) Allantoin Utilization X T2D_r2_120925_162_521_- FIG00017190 20 6 22 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_120941_1_293_- FIG00010738 16 5 18 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_r2_120941_294_521_- FIG00000601 12 5 13 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_120974_1_521_+ FIG00001209 104 17 105 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_121003_1_521_- FIG00000175 11 4 12 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_r2_121061_1_521_- FIG00052730 135 20 135 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_r2_121074_1_314_+ FIG00000148 6 3 7 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_r2_121088_104_521_- FIG00000159 25 7 27 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_r2_121095_1_521_- FIG00016145 40 11 43 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_121129_180_521_- FIG00000539 51 9 53 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_121138_1_521_+ FIG00002470 22 5 24 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_121154_154_521_+ FIG00000387 50 11 51 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_r2_121176_1_521_+ FIG01292786 19 7 21 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_r2_121230_47_520_- FIG00000738 49 10 51 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_121244_228_520_+ FIG00869624 5 2 7 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_r2_121264_1_520_+ FIG00075970 47 11 49 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_121267_1_128_+ FIG00016110 27 4 27 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_121267_174_520_+ FIG00001522 80 12 80 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_r2_121281_308_520_+ FIG00007079 10 3 12 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_121289_215_520_- FIG01260980 78 11 79 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_121436_1_520_- FIG00018699 24 9 25 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_121501_1_520_- FIG00023071 16 4 18 Multiple sugar metabolism regulator Streptococcus pyogenes recombinatorial zone 8 T2D_r2_121504_1_347_- FIG00088996 77 13 77 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_r2_121520_1_386_+ FIG00000301 21 9 54 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_r2_121526_304_519_+ FIG00000028 54 8 54 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r2_121549_35_519_- FIG00000112 96 16 97 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_r2_121573_1_202_- FIG00002560 46 8 46 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_121573_227_519_- FIG00067562 75 11 75 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_121593_1_183_- FIG00023946 8 3 10 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_121657_60_368_- FIG00000198 24 7 25 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_r2_121667_1_519_- FIG00009564 4 2 6 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_r2_121677_1_519_+ FIG00019251 85 14 86 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_121699_1_288_+ FIG00000402 8 4 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_121701_1_519_- FIG00000370 7 3 9 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_121704_1_445_+ FIG00002311 109 15 109 Septation ring formation regulator EzrA CBSS-393130.3.peg.794 2 T2D_r2_121712_1_519_- FIG00063189 86 15 87 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_r2_121730_1_519_+ FIG00018865 6 5 9 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_121751_320_519_+ FIG00133978 45 7 45 Ureidoglycolate dehydrogenase (EC 1.1.1.154) Allantoin Utilization X T2D_r2_121771_1_519_+ FIG00000738 50 11 51 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_121800_1_442_+ FIG00019251 40 8 41 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_121807_326_519_- FIG00067681 46 7 46 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_121857_23_518_- FIG00007137 9 3 10 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_121910_1_518_- FIG00000011 26 10 28 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_121919_1_518_- FIG00007328 7 4 9 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_121950_1_518_+ FIG00000032 70 14 72 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_121952_1_518_+ FIG00000402 51 11 52 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_121972_1_518_- FIG00002614 4 3 5 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_r2_122033_1_518_- FIG00005813 14 3 16 Negative regulator of genetic competence MecA Gram Positive Competence 3100 T2D_r2_122140_1_518_+ FIG00132839 6 2 7 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_122174_1_517_+ FIG00000762 53 12 54 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_r2_122206_1_517_+ FIG00023004 38 10 39 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_122278_1_246_+ FIG00013626 58 8 59 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_r2_122319_1_174_- FIG00029758 10 3 11 N-carbamoyl-L-amino acid hydrolase (EC 3.5.1.87) Hydantoin metabolism 4 T2D_r2_122352_1_354_- FIG00000687 65 13 66 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_r2_122375_1_185_+ FIG00037431 35 6 35 DNA repair protein RadC DNA repair, bacterial 3 T2D_r2_122381_84_517_- FIG00000681 12 4 13 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_r2_122421_1_517_+ FIG00137374 135 20 135 ATP-dependent DNA helicase SCO5184 DNA repair, bacterial RecBCD pathway 3 T2D_r2_122424_1_517_+ FIG00023369 28 5 30 Chaperone protein DnaK Protein chaperones 2.0 T2D_r2_122462_1_517_+ FIG00000032 33 7 35 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_122507_1_517_- FIG00043476 54 11 55 preQ1-regulated inosine-uridine nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_r2_122538_1_466_+ FIG00000962 105 16 105 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_122546_115_516_- FIG00000235 12 4 14 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_122596_1_173_- FIG00000193 43 7 43 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_r2_122614_1_516_+ FIG00024930 155 21 155 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_122679_1_516_+ FIG01260980 94 14 96 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_122702_1_494_- FIG00000069 18 6 19 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_122760_1_516_- FIG01260980 25 7 27 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_122807_1_516_- FIG00000244 88 15 89 Ketol-acid reductoisomerase (EC 1.1.1.86) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_122845_1_278_+ FIG00002049 23 5 24 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_122845_281_516_+ FIG00018865 3 3 4 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_122858_1_515_+ FIG00034851 44 12 47 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_122874_73_515_- FIG00051001 97 17 97 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Biotin biosynthesis 1X T2D_r2_122887_1_218_- FIG00000377 11 3 13 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_122893_93_356_- FIG00000053 17 4 18 LSU ribosomal protein L33p Ribosome LSU bacterial 9 T2D_r2_122901_1_515_- FIG00000402 12 6 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_122958_1_515_+ FIG00000405 46 11 47 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_r2_123027_208_515_- FIG00134368 6 3 8 Cytosine deaminase (EC 3.5.4.1) Creatine and Creatinine Degradation 4.0 T2D_r2_123040_1_515_- FIG00024930 22 6 24 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_123056_1_515_+ FIG00006151 54 10 56 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_123073_1_391_+ FIG00000088 12 4 16 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_123090_1_515_- FIG00051439 63 12 76 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_123097_1_515_- FIG00006151 11 5 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_123122_1_218_- FIG00001563 42 8 43 Preprotein translocase subunit SecG (TC 3.A.5.1.1) Murein hydrolase regulation and cell death 1.2 T2D_r2_123122_261_515_- FIG00000076 51 9 51 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_123148_1_515_+ FIG01304601 8 5 11 Exonuclease SbcC DNA repair, bacterial 3 T2D_r2_123213_137_514_+ FIG00000372 4 2 6 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_123250_1_514_- FIG01954097 9 9 11 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_123281_261_514_+ FIG00062547 64 9 64 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_r2_123296_1_514_- FIG00000241 69 13 70 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_123339_1_514_- FIG00000088 50 11 51 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_123340_1_514_+ FIG00002194 5 3 7 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_r2_123397_355_514_+ FIG00002574 16 4 17 2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37) Phosphonate metabolism 1 T2D_r2_123399_1_434_- FIG00006953 37 8 38 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_r2_123426_1_514_- FIG00000011 73 14 75 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_123505_1_353_- FIG00000985 91 14 91 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_r2_123511_1_274_- FIG00000273 14 5 15 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_r2_123540_1_398_- FIG00059124 71 13 72 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_r2_123588_43_513_- FIG00138523 6 3 8 Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_r2_123616_1_401_- FIG00846773 13 4 15 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_123639_1_311_+ FIG00001136 22 6 24 Urease accessory protein UreE Urease subunits 1.x T2D_r2_123692_338_513_+ FIG00025734 25 6 26 Predicted L-rhamnose ABC transporter, substrate-binding component L-rhamnose utilization 1 T2D_r2_123776_1_513_+ FIG00000011 11 3 13 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_123849_39_513_+ FIG00000341 67 15 69 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_123875_1_460_- FIG00044622 123 18 123 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_123887_94_512_- FIG00000001 6 4 8 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_123896_1_477_+ FIG00028203 52 12 53 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_123923_1_145_- FIG00012267 36 5 36 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_r2_123963_1_512_+ FIG00046929 38 10 39 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_123973_1_512_- FIG00000242 21 7 24 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_123984_139_512_+ FIG00000621 8 3 10 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_123990_353_512_+ FIG00000395 33 5 33 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_123991_1_512_+ FIG00030191 114 18 115 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_124000_181_512_- FIG00000216 42 8 43 LSU ribosomal protein L20p Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins) 1 T2D_r2_124011_1_204_- FIG00000116 47 8 47 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_124020_250_512_- FIG00058830 51 8 52 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_124048_1_398_+ FIG00000480 69 11 78 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_124052_1_512_+ FIG00000539 12 3 14 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_124071_1_512_+ FIG00042267 19 6 21 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_r2_124084_1_314_- FIG00059124 13 6 15 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_r2_124103_1_512_- FIG00003212 9 3 10 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_r2_124148_1_411_+ FIG00001208 18 4 19 [NiFe] hydrogenase metallocenter assembly protein HypD NiFe hydrogenase maturation 1 T2D_r2_124228_1_498_+ FIG00000555 12 7 16 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_124251_189_511_- FIG00084105 14 5 15 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_r2_124279_223_511_+ FIG00002251 15 5 17 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_124280_337_511_+ FIG00001635 22 4 23 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_124324_1_511_- FIG00010454 43 11 55 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_124435_1_373_- FIG00083946 26 6 29 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_124447_1_511_+ FIG00066575 5 4 6 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_124479_1_511_+ FIG00002239 128 20 128 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_124572_1_492_+ FIG00002049 10 6 13 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_124642_1_476_- FIG00002273 46 10 47 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_r2_124655_1_218_+ FIG00002716 6 2 7 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_r2_124696_143_510_- FIG00002020 5 2 6 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_124719_119_510_+ FIG00000128 38 8 40 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_124749_1_510_+ FIG00001354 75 14 77 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_r2_124756_1_396_+ FIG00001750 88 14 89 Carbon starvation protein A Carbon Starvation 1.21 T2D_r2_124758_157_510_- FIG00061313 10 4 11 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_r2_124806_1_510_+ FIG00002974 85 16 92 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_r2_124858_1_510_+ FIG00004078 29 8 32 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_124928_1_509_- FIG00451095 132 19 132 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_124978_1_509_+ FIG00059211 7 4 9 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_124984_1_509_- FIG00006691 115 18 115 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_124999_379_509_+ FIG00000448 6 2 7 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_125009_1_186_- FIG00054459 6 2 7 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_125009_305_509_- FIG00132586 16 5 18 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_r2_125049_1_509_+ FIG00000401 61 13 62 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_125128_64_509_+ FIG00003076 50 9 51 Lactam utilization protein LamB EC699-706 1 T2D_r2_125184_217_509_+ FIG00004744 5 2 7 Rare lipoprotein A precursor Peptidoglycan Biosynthesis 1.9 T2D_r2_125208_1_508_- FIG00001166 130 20 130 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_125242_322_508_+ FIG00000092 3 2 3 LSU ribosomal protein L31p Ribosome LSU bacterial 9 T2D_r2_125300_131_508_- FIG00041382 63 12 64 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_125327_141_508_+ FIG00000504 86 13 87 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_125342_36_508_+ FIG00021644 32 8 34 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_125378_1_427_+ FIG00007658 79 14 80 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_r2_125414_1_508_+ FIG00004763 133 20 133 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_125424_1_508_- FIG00003378 132 20 132 [NiFe] hydrogenase metallocenter assembly protein HypE NiFe hydrogenase maturation 1 T2D_r2_125506_1_508_+ FIG00130900 31 9 33 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_r2_125585_1_434_+ FIG00561498 112 16 112 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_125590_1_396_+ FIG00130344 112 16 112 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_125605_1_507_+ FIG00000825 51 10 53 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_125607_1_415_- FIG00000043 84 14 85 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_125658_80_507_+ FIG00009194 105 17 105 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_125672_1_507_- FIG00001347 25 9 26 Chitinase (EC 3.2.1.14) Chitin and N-acetylglucosamine utilization 2 T2D_r2_125757_1_507_+ FIG00000402 47 12 48 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_125792_1_507_- FIG00008507 35 10 36 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_r2_125806_1_507_- FIG00000838 9 5 12 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_125819_1_507_+ FIG00000962 134 19 134 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_125847_114_507_+ FIG00008736 16 5 18 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_125952_1_506_- FIG00041038 20 7 22 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_125959_1_502_+ FIG00067248 26 7 29 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_125974_1_506_+ FIG00000721 11 6 13 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_126003_1_506_+ FIG00000028 108 19 109 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r2_126022_1_282_- FIG00052605 20 4 22 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_126034_1_506_- FIG00008294 142 20 142 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_r2_126054_34_506_- FIG00019652 30 8 31 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_r2_126080_1_506_+ FIG00000990 62 11 65 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_126101_1_452_- FIG00001548 31 6 32 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_126143_1_506_- FIG00000268 19 8 20 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_126154_1_506_- FIG00031250 131 20 131 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_126244_1_506_+ FIG00049433 19 7 20 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_126298_150_505_+ FIG00000356 54 9 55 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_126343_1_505_- FIG00000539 65 13 66 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_126391_1_246_+ FIG00000267 12 3 13 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_r2_126391_287_505_+ FIG00052300 25 7 26 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r2_126397_1_505_+ FIG00745599 46 10 48 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_r2_126444_1_505_+ FIG00001871 6 2 8 Glycerol-3-phosphate ABC transporter, permease protein UgpE (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_126461_1_505_+ FIG00473043 88 14 88 Similar to CDP-glucose 4,6-dehydratase (EC 4.2.1.45) Acetoin, butanediol metabolism 5 T2D_r2_126507_1_476_+ FIG00459778 34 7 35 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_126513_1_505_- FIG00001294 10 3 12 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_r2_126530_1_211_+ FIG00047414 16 4 17 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_126538_1_505_- FIG00002944 5 4 7 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_r2_126545_1_505_+ FIG00026918 6 4 8 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_126546_1_505_+ FIG00002410 38 7 39 Recombinational DNA repair protein RecT (prophage associated) DNA repair, bacterial 3 T2D_r2_126563_1_323_+ FIG00000267 14 5 16 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_r2_126584_1_505_+ FIG00001653 20 5 21 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_r2_126587_1_317_- FIG00022631 3 3 6 Acetyl-coenzyme A synthetase (EC 6.2.1.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_126616_312_505_- FIG00006953 32 6 32 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_r2_126625_1_505_+ FIG00135554 56 10 57 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_r2_126649_1_505_- FIG00018865 25 9 27 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_126720_1_504_- FIG00057709 6 3 8 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_126725_1_504_+ FIG00022568 106 17 106 Phosphonate ABC transporter ATP-binding protein (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_r2_126738_1_146_- FIG00017454 12 3 13 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_126744_1_504_- FIG00000111 57 14 58 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_126754_1_504_- FIG00018699 113 19 114 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_126758_28_348_+ FIG00005329 32 7 34 V-type ATP synthase subunit F (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_126858_1_504_+ FIG00132839 68 12 70 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_126882_162_504_- FIG00000402 81 13 81 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_126887_75_504_+ FIG00009149 29 9 30 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_126892_1_281_- FIG00006764 3 2 4 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_r2_126946_9_504_- FIG00000343 54 11 56 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_126959_80_504_+ FIG00002300 46 9 48 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_r2_126990_1_504_+ FIG00040858 125 18 125 Additional periplasmic component NikK of nickel ECF transporter Transport of Nickel and Cobalt 7 T2D_r2_127012_1_504_+ FIG00013339 14 6 16 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_127089_1_503_+ FIG00001676 12 5 16 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_127094_108_503_+ FIG00554193 24 6 25 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_127164_1_503_+ FIG00561498 14 5 15 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_127175_1_503_+ FIG00001642 6 3 7 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_127204_1_503_- FIG00001361 22 6 26 Selenide,water dikinase (EC 2.7.9.3) Selenocysteine metabolism 1.1 T2D_r2_127271_1_503_+ FIG00451095 19 7 20 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_127284_1_503_+ FIG00000132 43 9 44 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_127338_1_464_+ FIG00001011 32 7 34 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_r2_127350_1_503_- FIG00138613 7 4 9 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.13.3) Aromatic Amin Catabolism 7 T2D_r2_127382_1_503_- FIG00000402 137 20 137 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_127396_1_502_+ FIG00001188 14 4 16 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_r2_127409_1_502_+ FIG00018699 15 5 17 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_127444_1_502_+ FIG00000434 60 14 62 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_127464_1_502_+ FIG00000086 17 3 20 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_r2_127469_61_502_- FIG01956071 4 2 6 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_r2_127471_1_502_+ FIG01260980 3 3 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_127488_1_502_- FIG00000184 35 11 37 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_127493_194_502_- FIG00168885 10 4 11 Cellobiose phosphorylase (EC 2.4.1.-) Beta-Glucoside Metabolism 2.bc T2D_r2_127521_138_502_+ FIG00000397 27 8 29 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_r2_127594_30_502_- FIG00000015 8 4 10 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_127602_1_502_+ FIG00000117 76 14 77 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_127605_1_502_- FIG00034293 34 7 35 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_127654_1_304_- FIG01955919 6 3 8 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_127729_1_502_+ FIG00001076 64 12 65 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_127760_272_501_- FIG00229386 3 2 4 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_127771_1_501_- FIG00010262 128 19 128 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) EC699-706 1 T2D_r2_127780_352_501_- FIG00006551 26 4 26 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_127781_1_317_- FIG00000385 81 12 81 Cell division protein FtsA Cell Division Cluster 1.x T2D_r2_127810_1_501_+ FIG00133219 28 9 29 Thiamin biosynthesis lipoprotein ApbE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_127838_1_501_+ FIG00089781 37 9 38 Possible alpha-xyloside ABC transporter, permease component Xylose utilization 1 T2D_r2_127872_146_501_+ FIG00006542 3 2 4 FIG006542: Phosphoesterase CBSS-257314.1.peg.676 4.x T2D_r2_127891_1_501_+ FIG00059211 3 3 5 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_127928_1_378_+ FIG00000147 60 11 62 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_127960_172_501_- FIG00007025 8 4 9 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_127991_1_183_+ FIG00067681 5 2 6 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_128034_1_464_+ FIG00024401 9 4 11 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_128054_1_501_- FIG01306479 78 12 79 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_128100_1_353_+ FIG00000383 19 7 20 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_r2_128102_1_262_+ FIG00000273 23 5 24 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_r2_128196_1_470_+ FIG00009156 8 5 9 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_r2_128199_1_294_- FIG00016061 4 2 6 L-lactate permease Lactate utilization 3 T2D_r2_128295_1_500_- FIG00561498 5 2 8 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_128344_1_500_+ FIG00000383 65 16 67 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_r2_128352_1_500_+ FIG00000245 44 9 46 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_128378_1_500_+ FIG00000333 138 20 138 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_128421_1_500_- FIG00000372 3 2 7 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_128468_1_500_- FIG00000113 58 14 59 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_128479_82_499_- FIG00000168 38 8 44 Transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_128502_243_425_+ FIG00000409 5 2 9 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_r2_128570_79_499_- FIG01031896 28 7 30 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_r2_128575_1_499_- FIG00006889 39 10 40 L-rhamnose isomerase (EC 5.3.1.14) L-rhamnose utilization 1 T2D_r2_128589_1_128_- FIG01262677 26 4 26 Alginate lyase precursor (EC 4.2.2.3) Alginate metabolism 4.xx T2D_r2_128590_1_455_+ FIG00451095 105 17 106 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_128651_1_499_- FIG00001562 135 20 135 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_r2_128699_1_499_+ FIG00000011 10 5 11 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_128702_102_499_- FIG00000377 24 5 25 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_128755_1_275_+ FIG00046358 15 4 21 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_128781_1_499_- FIG00054459 78 16 79 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_128803_345_499_+ FIG00000328 5 2 6 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_r2_128812_351_499_+ FIG00000433 20 5 21 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_128814_1_499_- FIG00000372 24 6 25 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_128875_1_498_- FIG01303154 112 18 113 Ubiquinone/menaquinone biosynthesis methyltransferase UbiE (EC 2.1.1.-) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r2_128917_1_127_- FIG00001020 17 3 17 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_128934_115_498_- FIG00003012 10 3 11 His repressor CBSS-393121.3.peg.1913 1 T2D_r2_129000_1_498_- 7 3 11 ATP-dependent protease La (EC 3.4.21.53) LonB Type I Proteasome bacterial 1 T2D_r2_129039_1_498_+ FIG00000412 41 10 42 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_129051_1_324_- FIG01260980 7 4 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_129081_1_498_- FIG00139262 128 19 128 Poly(glycerol-phosphate) alpha-glucosyltransferase (EC 2.4.1.52) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_129146_1_498_- FIG00021407 97 15 98 (R)-citramalate synthase (EC 2.3.1.182) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_129148_1_486_+ FIG00138004 15 5 18 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_129191_1_498_+ FIG00143531 3 4 8 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_r2_129198_1_193_- FIG00001311 35 5 35 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_r2_129198_198_498_- FIG00000482 75 11 75 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_129254_1_469_+ FIG00001237 58 12 59 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_r2_129277_1_378_+ FIG00000111 30 7 32 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_129295_1_406_+ FIG00000065 72 13 73 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_129385_1_497_- FIG00080955 33 8 35 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_129412_1_497_+ FIG00000422 57 14 76 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_r2_129438_352_497_- FIG00000122 9 3 10 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_129464_1_243_- FIG00048014 46 7 46 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_129482_1_358_+ FIG00000304 49 9 62 GTP-binding protein HflX Hfl operon 1.111 T2D_r2_129552_1_214_- FIG00005089 8 3 10 Spore cortex-lytic enzyme, lytic transglycosylase SleB Spore germination 1 T2D_r2_129649_1_332_- FIG00018369 87 13 87 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_129649_353_496_- FIG00000355 24 5 24 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_129696_1_496_+ FIG00000187 63 12 65 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_r2_129706_1_396_- FIG00000573 10 5 11 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_129709_1_204_- FIG00000015 4 2 6 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_r2_129709_316_496_- FIG00000531 13 4 15 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_129719_1_496_- FIG00018699 5 2 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_129726_128_496_+ FIG00044478 37 7 38 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_129763_1_419_+ FIG00034293 109 16 109 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_129772_141_496_+ FIG00001676 66 12 67 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_129774_1_496_- FIG00000555 13 3 15 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_129803_1_496_- FIG01305829 4 2 5 N-Acetyl-D-glucosamine permease 2, possible Chitin and N-acetylglucosamine utilization 2 T2D_r2_129811_109_496_+ FIG00066643 43 8 44 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_129819_1_473_+ FIG00000191 37 9 38 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_129893_293_496_- FIG00001106 26 5 26 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_r2_129901_1_496_+ FIG01260980 102 16 103 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_129919_1_496_+ FIG00001094 4 3 8 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_129930_1_265_+ FIG00000899 26 5 27 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_r2_129987_30_496_+ FIG00000532 71 16 72 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_130012_1_495_+ FIG00000132 18 6 19 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_130060_289_495_+ FIG00000086 46 7 46 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_r2_130089_1_495_+ FIG00000789 13 4 15 Phosphoenolpyruvate synthase (EC 2.7.9.2) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_130103_1_316_+ FIG00455853 63 10 64 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_130122_1_495_+ FIG00001469 9 5 10 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_130230_1_434_+ FIG00000350 10 5 11 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_130237_110_495_+ FIG01290653 35 7 36 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_130245_172_495_- FIG00017190 66 9 67 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_130249_1_495_+ FIG00067681 46 12 48 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_130258_1_495_+ FIG00002344 3 3 5 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r2_130301_1_495_+ FIG00000672 42 9 43 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_130302_1_495_+ FIG00079822 41 8 43 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_130337_158_495_- FIG00001497 13 3 15 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Cell division-ribosomal stress proteins cluster 1 T2D_r2_130393_1_494_- FIG00000011 82 16 83 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_130409_1_494_+ FIG00044478 39 10 42 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_130419_1_494_+ FIG00018699 12 5 14 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_130422_116_430_+ FIG00001676 78 12 78 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_130471_1_494_+ FIG00003439 24 5 25 Spore maturation protein A Spore Core Dehydration 1.1 T2D_r2_130532_1_448_- FIG00001384 5 3 15 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_130542_1_446_- FIG00133292 4 3 8 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_130569_1_463_- FIG00000280 48 10 49 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_130599_1_494_- FIG00046929 8 3 9 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_130605_362_494_+ FIG00000117 7 3 9 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_130631_1_244_+ FIG00000601 22 5 23 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_r2_130647_1_287_- FIG00010844 25 6 27 Flavodoxin Flavodoxin 1 T2D_r2_130658_1_494_- FIG00018369 17 3 19 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_130660_1_494_+ FIG00451095 129 19 129 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_130671_1_494_+ FIG00132839 6 3 7 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_130691_127_494_+ FIG00133292 41 9 43 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_130803_1_459_+ FIG00047056 23 6 24 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_r2_130810_1_493_- FIG00003555 9 4 11 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_130848_208_493_+ FIG00003555 12 5 14 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_130860_1_272_- FIG00010844 24 5 26 Flavodoxin Flavodoxin 1 T2D_r2_130868_1_351_+ FIG00006691 5 3 12 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_130913_1_493_+ FIG00018536 36 9 38 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_131001_1_493_+ FIG00001642 9 3 11 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_131007_1_493_- FIG00026006 144 20 144 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_131022_106_387_+ FIG00561498 72 10 72 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_131111_1_493_+ FIG00003410 6 2 7 Tagatose-6-phosphate kinase AgaZ (EC 2.7.1.144) N-Acetyl-Galactosamine and Galactosamine Utilization B.x T2D_r2_131138_1_221_- FIG00000575 4 2 6 L-aspartate oxidase (EC 1.4.3.16) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_r2_131142_179_493_- FIG00000434 90 12 90 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_131143_1_440_+ FIG00000102 83 14 84 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_131187_1_492_- FIG01260980 132 19 132 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_131238_1_492_- FIG00067248 59 13 60 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_131251_1_492_+ FIG00000477 30 8 32 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_131271_336_492_+ FIG00001550 29 6 29 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_r2_131276_1_398_- FIG00003756 23 6 24 Maltose-6'-phosphate glucosidase (EC 3.2.1.122) Maltose and Maltodextrin Utilization 1.x T2D_r2_131357_1_386_- FIG00006254 13 3 15 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) L-ascorbate utilization (and related gene clusters) 29 T2D_r2_131393_1_492_+ FIG00034392 34 10 36 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_131412_1_337_- FIG00001548 23 5 24 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_131428_1_492_+ FIG00023004 4 3 6 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_131442_1_492_+ FIG00017518 5 2 7 Alpha-L-arabinofuranosidase II precursor (EC 3.2.1.55) L-Arabinose utilization 1 T2D_r2_131470_1_492_- FIG00001676 28 7 30 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_131515_263_492_+ FIG00040817 12 4 14 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_131554_1_293_+ FIG00000557 57 10 68 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_r2_131598_270_491_- FIG00000085 9 3 11 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_131731_99_491_- FIG00001054 34 8 35 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_131742_1_197_- FIG00001175 20 4 21 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_131742_210_491_- FIG00000047 30 6 31 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_131747_1_491_+ FIG00000287 100 18 102 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_131763_1_470_- FIG00140555 8 5 13 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_131801_310_491_+ FIG00000659 23 6 24 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_131862_1_491_+ FIG00108342 128 18 128 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_131891_1_491_- FIG00021517 113 17 115 Cell division protein FtsQ Cell Division Cluster 1.x T2D_r2_131916_1_490_+ FIG00001269 31 6 32 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_131952_1_384_+ FIG00000793 74 12 75 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_131984_1_490_+ FIG00132617 89 15 90 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_131988_1_490_- FIG00016663 16 3 16 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_131993_1_283_+ FIG00084105 72 10 73 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_r2_132053_1_490_- FIG00013534 92 15 92 Substrate-specific component BL0695 of predicted ECF transporter ECF class transporters 345678 T2D_r2_132136_123_368_+ FIG00132801 8 3 10 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_r2_132143_1_490_+ FIG00026137 82 15 83 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_132150_1_490_+ FIG00000380 33 8 35 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_132166_1_490_+ FIG00000414 19 5 20 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_r2_132197_1_490_+ FIG00074225 9 3 11 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_132267_1_136_- FIG00000430 28 4 28 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_r2_132280_1_490_+ FIG00000402 48 10 49 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_132302_1_265_- FIG00044622 68 10 68 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_132313_268_489_- FIG00047509 3 2 4 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_132341_1_249_- FIG00000402 30 6 31 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_132414_1_489_- FIG00000308 26 8 27 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_r2_132423_20_489_- FIG00022300 123 18 123 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_132440_1_364_- FIG00006167 76 13 76 Clostridial MutS2-related protein DNA repair, bacterial MutL-MutS system 1 T2D_r2_132499_45_489_- FIG00048268 3 3 5 Membrane protein associated with methylmalonyl-CoA decarboxylase Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_132506_190_489_- FIG00000267 3 2 4 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_r2_132548_1_409_+ FIG00000134 100 15 100 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_132619_1_489_- FIG00000672 29 8 31 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_132645_1_489_- FIG00719736 41 9 43 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_132647_138_489_- FIG00229386 101 14 101 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_132671_1_489_- FIG00018369 34 10 38 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_132679_93_489_- FIG00138468 15 3 17 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_132680_1_489_+ FIG00035627 37 8 39 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_132790_171_488_- FIG00000464 13 4 14 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_132851_1_242_+ FIG00000043 44 9 44 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_132880_146_488_+ FIG00000641 77 12 78 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_132942_1_405_+ FIG00004655 3 2 4 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_r2_132943_1_488_- FIG00018369 106 17 106 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_132949_1_488_+ FIG01260980 5 4 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_133036_1_218_+ FIG00003596 53 8 53 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_r2_133040_1_488_- FIG00075702 48 9 49 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_133052_1_488_+ FIG00089870 43 10 45 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_r2_133069_176_488_- FIG00000184 36 7 38 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_133099_1_488_- FIG00000402 115 19 115 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_133100_126_488_- FIG00000242 39 8 41 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_133106_184_488_- FIG00000047 5 3 6 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_133144_1_487_- FIG00000404 10 4 13 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_133159_54_245_- FIG00000266 48 7 48 LSU ribosomal protein L28p A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_133239_1_487_+ FIG00007960 3 2 6 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_133268_1_426_+ FIG00018865 9 7 15 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_133274_1_487_+ FIG01260980 11 6 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_133275_1_345_+ FIG00000990 12 4 13 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_133280_1_487_+ FIG00041038 12 3 14 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_133305_1_487_- FIG00000494 48 11 50 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_133347_80_487_+ FIG00000979 122 16 122 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_r2_133362_168_487_+ FIG00000782 83 12 83 Exonuclease SbcD DNA repair, bacterial 3 T2D_r2_133411_1_487_- FIG00014849 27 6 29 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_r2_133458_1_388_+ FIG00017190 11 3 12 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_133502_1_486_- FIG00001548 122 19 122 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_133533_1_486_+ FIG00000624 112 18 113 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_133557_1_486_- FIG00001635 16 6 18 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_133558_6_486_+ FIG00000038 9 4 10 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_133587_1_358_+ FIG00000131 48 10 49 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_133593_1_248_- FIG00027226 46 8 46 DnaJ-class molecular chaperone CbpA Protein chaperones 2.0 T2D_r2_133614_1_486_+ FIG00000578 77 15 78 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_133620_54_221_+ FIG00001676 14 4 15 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_133662_1_486_- FIG00000224 7 4 8 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r2_133672_1_382_+ FIG00001440 29 8 30 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_133684_1_486_+ FIG00024851 51 12 53 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_133688_1_442_+ FIG00079822 45 12 46 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_133694_1_486_+ FIG00000001 34 6 36 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_133769_1_323_- FIG00000449 61 11 61 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_r2_133771_1_486_+ FIG00561498 10 4 11 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_133772_1_486_- FIG01260980 94 15 95 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_133821_1_486_- FIG00018457 5 2 7 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_133827_1_486_+ FIG00002050 47 11 51 Urease alpha subunit (EC 3.5.1.5) Urease subunits 1.x T2D_r2_133852_1_486_- FIG00029916 125 19 125 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_r2_133872_1_485_- FIG00000023 86 15 88 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_r2_133946_1_485_+ FIG00011537 41 11 42 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_134005_1_365_- FIG00405688 84 14 84 Teichuronic acid biosynthesis protein TuaE, putative secreted polysaccharide polymerase Teichuronic acid biosynthesis 9 T2D_r2_134096_1_323_+ FIG00000695 10 2 13 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_134183_1_485_- FIG00001642 5 4 6 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_134190_1_485_+ FIG00080955 120 18 120 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_134204_1_485_- FIG00025216 12 5 14 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_134206_232_485_+ FIG00000224 6 3 7 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r2_134227_64_354_+ FIG00003307 17 5 19 FIG003307: hypothetical protein CBSS-323097.3.peg.2594 1 T2D_r2_134231_193_485_- FIG00000210 10 4 13 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_r2_134273_1_484_+ FIG00719736 47 13 49 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_134311_1_484_+ FIG00000055 36 10 37 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_r2_134318_1_204_+ FIG00026750 8 3 10 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_r2_134334_1_484_- FIG00000863 9 4 11 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_r2_134355_1_306_- FIG00000704 61 10 61 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_r2_134385_1_484_+ FIG00005216 40 8 42 Sulfate permease Cysteine Biosynthesis 2.17 T2D_r2_134408_61_484_+ FIG00000343 53 11 54 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_134473_1_484_+ FIG00126843 11 4 13 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_134500_215_484_- FIG00451095 65 10 65 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_134514_1_484_+ FIG00001642 34 9 35 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_134533_1_394_+ FIG00001547 94 13 95 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_134536_1_484_- FIG00042616 76 14 78 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_134542_1_484_- FIG00000356 65 14 66 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_134551_1_290_- FIG00000962 14 5 15 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_134564_1_484_+ FIG00001642 13 6 16 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_134566_1_376_+ FIG00042267 19 7 20 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_r2_134604_267_484_- FIG00000348 54 8 55 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_r2_134615_1_483_+ FIG01007502 3 3 4 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_134646_1_483_+ FIG00000494 41 9 42 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_134701_1_483_- FIG00001824 62 13 63 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_134713_82_483_- FIG00129130 81 15 82 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_r2_134800_1_380_+ FIG00010194 4 2 5 Cell wall surface anchor family protein Sortase 1.12 T2D_r2_134826_1_483_- FIG00018176 77 13 78 Phospholipid-lipopolysaccharide ABC transporter N-linked Glycosylation in Bacteria 2.0 T2D_r2_134852_325_483_- FIG00006167 42 6 42 Clostridial MutS2-related protein DNA repair, bacterial MutL-MutS system 1 T2D_r2_134904_316_483_- FIG00016145 16 4 17 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_134907_1_152_+ FIG00000244 15 3 15 Ketol-acid reductoisomerase (EC 1.1.1.86) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_134923_1_483_+ FIG01260980 124 19 124 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_134960_1_483_- FIG00132666 13 4 15 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_134998_351_482_- FIG01955850 6 2 7 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_135008_1_435_- FIG00001676 16 4 19 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_135059_1_314_+ FIG00138354 4 3 6 Alkanesulfonates transport system permease protein Alkanesulfonates Utilization 20 T2D_r2_135077_1_306_+ FIG00229199 11 6 12 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_r2_135085_1_482_- FIG00000264 96 17 96 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_r2_135098_1_482_- FIG00000420 67 14 68 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_135106_355_482_+ FIG00109688 11 3 12 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_r2_135108_1_482_- FIG00000352 65 13 67 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r2_135116_1_459_+ FIG00000538 110 17 112 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_r2_135118_1_482_- FIG00134135 28 9 31 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_135128_1_482_- FIG00031723 21 5 23 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_r2_135131_1_482_+ FIG00000268 75 13 78 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_135149_1_182_- FIG00006551 32 6 32 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_135149_197_482_- FIG00020185 61 11 61 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_135169_1_482_- FIG00010454 9 6 11 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_135170_1_389_+ FIG00000122 71 13 72 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_135194_1_482_+ FIG01010650 96 15 96 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_135201_1_239_- FIG00000298 35 6 37 GTP-binding protein EngB Universal GTPases 2 T2D_r2_135267_1_318_- FIG00138468 17 5 18 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_r2_135280_106_482_- FIG00021289 79 14 79 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_135305_1_482_- FIG00016110 16 6 19 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_135350_1_186_+ FIG00003460 37 6 37 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_135368_30_482_- FIG00075970 36 8 37 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_135381_1_481_- FIG00000877 111 16 116 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_135427_1_481_+ FIG00000773 81 14 81 Glutamyl-tRNA synthetase (EC 6.1.1.17) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_135481_1_481_+ FIG00010285 31 7 32 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_r2_135564_1_481_+ FIG00000402 53 11 55 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_135581_1_321_- FIG00001687 13 3 14 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_135624_1_481_- FIG00016555 127 18 127 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_r2_135632_1_255_+ FIG00000777 10 3 11 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_135641_1_159_+ FIG01260980 28 5 29 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_135695_1_454_- FIG00037431 6 2 8 DNA repair protein RadC DNA repair, bacterial 3 T2D_r2_135723_1_481_- FIG00052605 43 7 45 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_135761_1_417_- FIG00002470 12 4 14 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_135770_1_480_+ FIG00001548 21 6 29 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_135781_1_167_+ FIG00002541 20 4 21 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_135781_221_480_+ FIG00000721 10 2 11 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_135795_105_480_- FIG00007960 6 4 7 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_135803_1_305_+ FIG00000441 15 4 17 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_135806_1_480_- FIG00061832 92 15 95 Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) Sialic Acid Metabolism 1.x T2D_r2_135829_1_310_+ FIG00001834 8 4 9 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_135854_220_480_+ FIG00019251 13 2 14 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_135882_1_480_- FIG00059211 14 5 17 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_135907_233_480_- FIG00051439 16 4 18 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_135910_1_270_+ FIG00000212 47 9 47 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_r2_135957_44_480_- FIG00001676 112 17 112 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_136001_1_480_+ FIG00049915 60 11 62 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_r2_136019_1_480_+ FIG01260980 72 14 73 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_136084_1_480_- FIG00011537 32 8 33 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_136131_1_234_+ FIG00006691 4 2 5 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_136140_1_480_+ FIG00003845 37 10 38 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_r2_136148_195_480_+ FIG00001022 18 4 20 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_136152_1_480_+ FIG00000208 97 15 98 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_r2_136183_1_480_+ FIG01304329 107 19 107 Chromosome (plasmid) partitioning protein ParA Cell Division Subsystem including YidCD 1 T2D_r2_136185_1_200_+ FIG00058830 9 2 10 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_136186_248_480_+ FIG00000385 11 3 13 Cell division protein FtsA Cell Division Cluster 1.x T2D_r2_136227_1_479_- FIG00044622 132 19 132 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_136243_1_479_- FIG00040817 60 11 62 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_136269_1_479_+ FIG00034293 21 8 23 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_136288_1_479_- FIG00016768 5 2 6 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_136366_1_479_- FIG00001469 9 4 11 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_136493_315_479_+ FIG00037431 11 3 12 DNA repair protein RadC DNA repair, bacterial 3 T2D_r2_136520_1_479_+ FIG00060517 16 7 18 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_r2_136527_1_479_- FIG00026750 28 6 30 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_r2_136572_1_479_+ FIG00076542 44 10 46 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_r2_136603_1_478_+ FIG00000333 45 11 68 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_136624_135_478_- FIG00075970 16 4 17 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_136649_270_478_- FIG00007960 45 7 45 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_136671_68_478_+ FIG00106663 88 15 89 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_136681_1_478_+ FIG00006117 10 3 11 Agmatine/putrescine antiporter, associated with agmatine catabolism Polyamine Metabolism 2 T2D_r2_136692_1_478_- FIG00000210 13 5 16 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_r2_136708_281_478_- FIG00000039 31 6 31 Translation elongation factor Tu Translation elongation factors bacterial 1.1 T2D_r2_136726_231_478_+ FIG00005308 14 5 16 Catabolite repression HPr-like protein Crh HPr catabolite repression system 1 T2D_r2_136766_194_478_- FIG00000333 16 5 17 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_136843_1_478_- FIG01321404 103 17 103 Probable glutamate/gamma-aminobutyrate antiporter cAMP signaling in bacteria 4.1007 T2D_r2_136850_1_202_+ FIG00000420 8 2 9 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_136851_1_478_+ FIG00006151 77 13 77 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_136852_1_406_+ FIG00018369 47 8 49 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_136928_307_478_- FIG00000116 14 4 15 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_136932_1_318_+ FIG00000207 8 2 10 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_136950_1_294_+ FIG00000166 11 6 14 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_r2_136971_1_477_+ FIG00021289 5 3 8 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_137018_1_477_- FIG00459778 135 19 135 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_137070_1_477_- FIG00000320 12 4 13 Ubiquinone biosynthesis monooxygenase UbiB Ubiquinone Biosynthesis 2.x T2D_r2_137157_244_477_+ FIG00049915 40 7 40 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_r2_137187_44_477_- FIG00000838 29 5 30 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_137190_1_423_+ FIG00000621 36 9 37 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_137193_1_477_+ FIG00002239 118 18 118 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_137222_165_477_+ FIG00057709 18 5 20 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_137242_262_477_+ FIG00000866 13 4 14 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r2_137258_1_477_- FIG01305829 6 4 8 N-Acetyl-D-glucosamine permease 2, possible Chitin and N-acetylglucosamine utilization 2 T2D_r2_137313_1_282_- FIG00006151 35 8 35 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_137318_1_477_+ FIG00002716 9 4 11 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_r2_137378_1_476_+ FIG00001354 76 15 77 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_r2_137392_1_368_- FIG00000088 14 4 16 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_137422_1_476_+ FIG00000815 79 13 80 Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE Biogenesis of c-type cytochromes 1.1 T2D_r2_137430_78_260_- FIG00000409 4 2 5 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_r2_137430_274_476_- FIG00000155 9 3 10 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_r2_137438_1_476_- FIG00001188 7 6 9 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_r2_137456_1_147_+ FIG00000309 13 2 14 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_r2_137480_33_476_+ FIG01271998 10 3 10 Possible hypoxanthine oxidase XdhD (EC 1.-.-.-) Purine conversions 4.1118100 T2D_r2_137481_1_476_- FIG00138960 128 19 128 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_r2_137501_1_476_+ FIG00000377 6 3 7 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_137527_1_476_- FIG00000391 42 8 44 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_r2_137536_1_400_+ FIG00010478 99 15 99 Phosphonate ABC transporter permease protein phnE2 (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_r2_137569_1_476_+ FIG00041038 46 10 46 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_137588_1_476_- FIG00133583 115 17 115 Predicted cobalt transporter in sulfate-reducing delta-proteobacteria Transport of Nickel and Cobalt 7 T2D_r2_137616_278_476_+ FIG00000641 5 4 7 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_137637_1_476_- FIG00000573 5 5 14 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_137659_158_476_+ FIG00038343 13 2 14 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_r2_137678_1_476_+ FIG00000636 117 17 118 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_137699_84_476_+ FIG00002914 24 7 25 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_137711_1_476_- FIG00052605 40 10 42 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_137716_1_360_+ FIG00006336 100 14 100 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_r2_137728_1_476_- FIG00002020 15 4 18 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_137738_1_319_+ FIG00003751 10 4 11 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_r2_137780_1_475_- FIG00013638 73 14 74 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_137813_12_475_+ FIG00000350 22 6 23 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_137817_1_475_+ FIG00019251 5 4 7 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_137821_19_475_+ FIG00003076 110 16 110 Lactam utilization protein LamB EC699-706 1 T2D_r2_137912_1_230_- FIG00001577 14 4 16 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_r2_137953_1_325_+ FIG00003555 8 3 11 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_137998_1_475_- FIG01260980 6 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_138004_82_475_+ FIG00031250 20 5 24 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_138009_266_475_+ FIG00009628 14 5 15 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_r2_138017_54_475_+ FIG00000362 52 9 54 Lipoate synthase Lipoic acid metabolism 5.0 T2D_r2_138021_1_475_- FIG00004078 67 13 69 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_138023_1_475_+ FIG00000356 125 18 125 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_138033_1_475_+ FIG00561498 23 6 24 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_138075_138_475_+ FIG01016270 77 12 78 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_r2_138101_1_219_+ FIG00138413 52 8 53 Fructose-1,6-bisphosphatase, GlpX type (EC 3.1.3.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_138183_1_251_+ FIG00001269 15 5 17 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_138213_225_474_- FIG00011382 3 3 7 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_r2_138223_1_474_+ FIG00451095 5 2 8 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_138234_1_474_+ FIG00041038 14 7 16 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_138254_1_447_- FIG00004105 9 2 10 Periplasmic thiol:disulfide interchange protein, DsbA-like Periplasmic disulfide interchange 1 T2D_r2_138307_1_389_- FIG00000365 15 5 17 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_r2_138313_131_474_+ FIG00000084 97 14 97 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_r2_138325_1_474_- FIG00001531 27 8 28 D-alanyl transfer protein DltB D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_r2_138426_1_474_+ FIG00132617 21 8 23 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_138435_268_474_- FIG00006092 8 3 9 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_138440_1_456_+ FIG00000323 122 18 122 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_138469_51_308_- FIG01955902 21 4 21 Rubredoxin Rubrerythrin 2 T2D_r2_138473_1_474_- FIG00002872 15 6 17 D-galactarate dehydratase (EC 4.2.1.42) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_138482_1_474_+ FIG00000088 45 12 47 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_138505_1_474_- FIG00001065 5 5 8 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_138529_34_474_- FIG00017454 119 17 119 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_138538_1_474_- FIG00000402 3 2 4 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_138565_1_474_- FIG01310319 8 3 10 Exoenzymes regulatory protein AepA in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_r2_138601_212_473_- FIG00023004 11 4 12 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_138628_1_473_+ FIG00000762 20 7 21 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_r2_138673_1_207_+ FIG00000191 6 2 7 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_138679_1_312_+ FIG00000185 23 7 24 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_138730_170_473_- FIG00038343 11 3 12 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_r2_138733_1_246_+ FIG00000962 52 9 52 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_138737_1_440_+ FIG00006235 98 15 98 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_r2_138741_1_141_- FIG00001822 9 3 10 Pantothenate:Na+ symporter (TC 2.A.21.1.1) Coenzyme A Biosynthesis A.191 T2D_r2_138763_1_473_- FIG00000446 110 17 111 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_138780_1_473_+ FIG00010738 25 6 26 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_r2_138885_1_473_+ FIG00000372 33 8 35 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_138891_1_473_+ FIG00031250 132 19 132 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_138897_1_473_- FIG00022899 17 7 19 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_138905_1_420_+ FIG00000047 41 10 42 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_138927_1_473_+ FIG00000131 66 13 67 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r2_138962_1_473_+ FIG00000146 69 13 70 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_138986_137_473_+ FIG00038814 51 10 53 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_r2_138995_165_473_- FIG01956126 18 6 20 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_139036_1_472_+ FIG01304886 15 6 17 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_r2_139050_1_472_+ FIG00132586 14 5 15 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_r2_139073_1_383_- FIG01955809 8 3 10 Cytoplasmic copper homeostasis protein cutC Copper homeostasis: copper tolerance 3 T2D_r2_139082_1_472_+ FIG00000139 21 5 24 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_139087_1_472_+ FIG00000112 64 12 65 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_r2_139100_318_472_+ FIG00000421 9 2 10 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_r2_139167_1_472_+ FIG00008490 63 13 64 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_139169_1_472_+ FIG01955857 95 17 95 Sensor protein of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_139189_1_472_- FIG00719736 7 4 8 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_139190_1_472_- FIG00120441 133 19 133 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_r2_139196_1_472_+ FIG00026918 16 6 18 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_139205_1_443_+ FIG00000043 16 4 18 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_139227_1_294_- FIG00000636 58 9 59 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_139237_1_296_- FIG01007502 5 4 7 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_139248_1_472_- FIG00024930 12 5 14 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_139261_1_472_+ FIG00001221 125 18 125 Alkanesulfonates-binding protein Alkanesulfonates Utilization 20 T2D_r2_139366_1_290_- FIG00106663 51 8 51 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_139381_1_472_+ FIG00001067 87 15 88 Rubrerythrin Oxidative stress 1.2 T2D_r2_139405_183_472_- FIG00000080 8 2 10 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_139424_1_472_+ FIG00002251 124 17 125 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_139434_1_287_- FIG00004014 17 4 18 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_r2_139502_1_471_- FIG00001269 33 8 35 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_139514_1_471_- FIG00014777 128 19 128 5-keto-2-deoxygluconokinase (EC 2.7.1.92) Inositol catabolism 5.x T2D_r2_139561_1_471_- FIG00005022 18 5 19 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_r2_139615_128_471_+ FIG00006046 15 4 16 CRISPR-associated RAMP Csm3 CRISPR-associated cluster 1 T2D_r2_139620_1_471_- FIG00000477 127 18 127 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_139691_1_471_+ FIG00003520 95 14 96 Phage tail fiber protein Phage tail fiber proteins 2 T2D_r2_139696_1_471_- FIG00006128 6 4 8 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_139760_1_471_- FIG00000245 39 8 40 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_139770_1_194_- FIG00001000 4 2 5 Sulfate and thiosulfate binding protein CysP Cysteine Biosynthesis 2.17 T2D_r2_139781_1_471_- FIG00018396 9 4 12 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_139784_1_214_+ FIG00018536 7 3 9 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_139784_271_471_+ FIG00022976 4 3 5 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_139836_1_471_+ FIG00000122 43 10 44 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_r2_139989_1_470_- FIG00001269 96 15 96 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_140020_27_470_+ FIG00003555 33 8 36 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_140032_121_470_+ FIG00000350 80 12 80 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_140053_1_153_+ FIG00000132 12 2 14 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_140081_47_470_- FIG00561498 17 4 18 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_140082_1_470_+ FIG00049433 24 9 26 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_140086_1_470_+ FIG00000412 3 3 5 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_140138_37_470_- FIG00067248 71 12 72 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_140183_1_470_+ FIG00044622 76 13 77 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_140214_1_243_+ FIG00051882 18 7 20 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Cobalamin synthesis 2 T2D_r2_140241_26_256_+ FIG00003472 6 2 7 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_140242_1_327_+ FIG00000962 72 12 72 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_140269_1_470_+ FIG00132617 69 12 70 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_140337_1_469_- FIG00000356 124 18 124 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_140382_1_469_- FIG00013712 88 13 90 Predicted N-ribosylNicotinamide CRP-like regulator NAD and NADP cofactor biosynthesis global E T2D_r2_140388_83_469_- FIG00010844 6 2 8 Flavodoxin Flavodoxin 1 T2D_r2_140433_41_469_- FIG00001188 4 2 5 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_r2_140443_11_469_+ FIG00005992 113 17 113 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_140513_1_256_+ FIG00000350 16 4 18 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_140523_1_292_- FIG00047509 18 4 22 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_140535_1_317_+ FIG00000467 55 9 56 Biotin synthase (EC 2.8.1.6) Biotin biosynthesis 1X T2D_r2_140565_1_469_+ FIG00000578 5 4 7 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_r2_140582_1_469_+ FIG00000145 110 17 110 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_r2_140643_1_469_+ FIG00001209 22 7 24 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_140706_1_468_- FIG00000990 11 6 15 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_140737_1_468_+ FIG00001062 124 17 124 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_r2_140750_275_468_+ FIG00002328 21 5 22 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_140760_142_312_+ FIG00000838 33 6 33 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_140770_1_468_- FIG00041038 34 9 36 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_140955_1_468_+ FIG00058830 61 11 62 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_140958_103_468_- FIG00122145 10 3 11 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_140971_227_468_- FIG00122145 3 3 4 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_140972_187_468_+ FIG00020897 76 11 76 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_r2_140993_1_391_+ FIG00066575 10 4 13 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_140996_1_468_+ FIG00003439 16 5 26 Spore maturation protein A Spore Core Dehydration 1.1 T2D_r2_141078_1_468_+ FIG00018699 56 12 57 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_141087_1_468_- FIG00000552 7 2 8 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_r2_141121_1_467_- FIG00013638 42 12 43 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_141151_1_333_- FIG00031250 71 11 72 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_141233_1_188_+ FIG00048014 6 2 8 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_141254_1_190_- FIG00055715 34 6 34 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_141385_1_467_+ FIG00034293 71 13 72 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_141393_4_467_- FIG00000001 31 7 33 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_141396_1_467_+ FIG00002914 21 5 32 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_141458_1_467_- FIG00000112 73 14 75 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_r2_141533_1_467_+ FIG00002050 50 11 52 Urease alpha subunit (EC 3.5.1.5) Urease subunits 1.x T2D_r2_141556_1_466_+ FIG00001022 126 18 126 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_141576_1_458_+ FIG00000011 5 4 7 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_141586_1_466_- FIG00000695 10 3 12 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_141612_1_412_+ FIG00000070 80 13 81 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_141635_1_466_- FIG00000510 31 8 35 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_r2_141675_1_466_+ FIG01304601 55 12 56 Exonuclease SbcC DNA repair, bacterial 3 T2D_r2_141681_213_466_+ FIG01955782 56 9 56 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_r2_141726_1_320_- FIG00000404 6 2 10 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_141727_1_466_+ FIG01266244 46 9 47 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_141809_1_433_- FIG00001470 24 5 25 Signal recognition particle associated protein Two cell division clusters relating to chromosome partitioning 1 T2D_r2_141876_70_466_+ FIG00000397 19 6 20 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_r2_141915_48_466_- FIG00000402 25 4 29 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_141916_1_304_+ FIG00000404 30 5 32 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_141920_1_466_- FIG00130344 16 6 18 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_141924_1_466_- FIG00003580 109 16 110 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_141965_1_450_+ FIG00000323 27 7 29 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_142011_1_465_+ FIG00093180 8 3 9 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_142024_1_465_+ FIG00025216 6 3 8 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_142045_1_255_- FIG00000011 7 3 9 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_142180_1_465_- FIG00000258 19 6 26 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_r2_142210_1_465_- FIG00001385 84 14 85 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_142213_1_377_- FIG00000402 9 3 11 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_142462_1_464_+ FIG00003555 3 4 6 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_142482_1_287_+ FIG00000590 6 2 8 NAD synthetase (EC 6.3.1.5) NAD and NADP cofactor biosynthesis global E T2D_r2_142547_258_464_- FIG00052605 13 4 14 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_142572_1_464_- FIG00000134 122 18 122 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_142599_1_464_+ FIG00018699 4 4 7 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_142613_301_464_- FIG00021644 16 3 17 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_142684_1_464_- FIG00018457 40 8 42 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_142729_177_464_- FIG00000402 11 4 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_142748_1_464_- FIG00003460 112 17 112 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_142829_1_463_+ FIG00003715 104 16 104 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_142836_239_463_- FIG00001636 3 2 6 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_r2_142854_1_363_- FIG00134830 38 7 39 Lysine 2,3-aminomutase (EC 5.4.3.2) Lysine degradation 1.0 T2D_r2_142908_1_263_+ FIG00000271 67 10 67 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_r2_142908_327_463_+ FIG00000223 33 5 33 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_r2_142920_1_399_+ FIG01260980 32 7 33 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_142921_63_463_- FIG00001670 7 3 8 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_r2_142955_1_322_- FIG00004788 7 3 8 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_r2_142968_253_463_- FIG00000641 51 8 51 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_142988_39_463_+ FIG00001530 5 3 6 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_r2_143075_1_463_- FIG00000234 62 12 63 RecA protein CBSS-257314.1.peg.676 4.x T2D_r2_143078_1_463_+ FIG00000441 28 5 29 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_143128_1_378_+ FIG00010600 12 6 13 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_r2_143149_19_463_- FIG00018865 80 15 80 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_143157_1_463_- FIG00221658 5 2 7 Alpha-arabinosides ABC transport system, substrate-binding protein L-Arabinose utilization 1 T2D_r2_143191_1_463_+ FIG00067681 84 15 85 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_143217_59_462_- FIG00060294 58 12 74 ABC transport system, permease component YbhS ATP-dependent efflux pump transporter Ybh 1 T2D_r2_143242_1_462_- FIG00058830 42 9 43 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_143291_1_462_- FIG00034851 113 17 113 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_143292_1_462_+ FIG00002718 104 16 104 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_143298_259_462_+ FIG00136922 26 5 26 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_143303_1_462_- FIG00000087 21 5 22 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_r2_143312_1_462_- FIG00023463 65 10 66 heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta Anaerobic respiratory reductases 3 T2D_r2_143339_1_273_+ FIG00000838 5 4 7 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_143364_1_129_+ FIG00000276 13 3 14 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_r2_143392_1_462_- FIG00000156 48 9 49 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_143421_210_398_- FIG00006632 8 2 9 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_r2_143476_294_462_- FIG00007960 31 6 31 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_143488_1_307_+ FIG00000025 19 4 20 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_143490_1_305_- FIG00004743 41 9 43 Lactoylglutathione lyase (EC 4.4.1.5) Methylglyoxal Metabolism 3.x T2D_r2_143549_1_462_+ FIG00001794 104 17 104 Deacetylases, including yeast histone deacetylase and acetoin utilization protein Hydantoin metabolism 4 T2D_r2_143558_157_462_+ FIG01266244 63 11 64 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_143560_1_235_+ FIG00000252 57 8 57 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_r2_143631_161_462_- FIG00001094 9 3 11 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_143637_1_462_- FIG00031250 87 15 88 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_143655_1_141_- FIG00006551 8 3 9 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_143655_156_462_- FIG00020185 23 6 24 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_143692_84_461_- FIG00017190 105 14 105 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_143700_1_461_+ FIG00846773 90 15 90 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_143726_1_281_- FIG00000863 72 10 72 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_r2_143756_1_461_+ FIG00000402 55 12 56 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_143795_1_461_- FIG00001469 14 6 15 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_143810_1_384_+ FIG00000840 6 3 8 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_r2_143823_1_461_+ FIG00020897 5 4 7 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_r2_143825_1_412_+ FIG00004568 6 4 8 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Alkanesulfonate assimilation 9.? T2D_r2_143877_1_461_+ FIG00004917 25 7 26 Protein AraJ precursor L-Arabinose utilization 1 T2D_r2_143883_1_461_- FIG00041382 121 18 121 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_143921_1_461_- FIG00003381 102 18 102 L-cystine uptake protein TcyP L-Cystine Uptake and Metabolism 6.0 T2D_r2_143922_170_461_- FIG00000636 29 7 30 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_143941_1_461_- FIG00000395 22 6 23 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_143991_1_461_- FIG00000268 128 18 129 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_144008_1_211_- FIG00000001 26 6 27 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_144012_1_461_+ FIG00021289 131 18 131 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_144077_1_461_+ FIG00004172 95 17 97 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_144116_1_461_+ FIG01031896 27 8 29 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_r2_144235_1_225_- FIG00010876 59 9 59 Two-component sensor kinase YesM (EC 2.7.3.-) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_144255_1_460_+ FIG00001583 39 9 41 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_r2_144278_27_460_- FIG00003435 71 14 72 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_144312_1_460_- FIG00016555 3 2 6 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_r2_144386_1_460_+ FIG00000573 13 5 15 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_144419_1_144_- FIG00000211 34 5 34 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_r2_144453_1_279_- FIG00000520 73 11 73 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_144462_1_460_- FIG00000680 5 2 7 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_r2_144501_1_266_+ FIG00623809 20 5 21 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_144504_248_460_- FIG00001642 24 5 25 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_144525_131_460_+ FIG00000224 8 3 9 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r2_144537_1_460_- FIG00120441 132 18 132 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_r2_144597_1_375_- FIG00011987 4 3 6 Stage III sporulation protein AD Sporulation Cluster III A 1.x T2D_r2_144603_1_459_+ FIG00008591 5 2 6 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_r2_144611_1_459_- FIG00001168 8 6 10 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_144629_1_459_- FIG00052730 41 8 43 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_r2_144656_208_459_+ FIG00000279 30 7 31 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_144697_1_168_+ FIG00031250 6 3 7 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_144707_196_459_+ FIG00015476 19 4 20 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_r2_144724_1_459_+ FIG01260980 4 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_144758_1_459_+ FIG00000146 47 8 48 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_144769_1_459_+ FIG00022899 30 7 31 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_144773_1_373_- FIG00016566 20 4 21 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_r2_144805_1_370_+ FIG00000088 21 5 22 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_144831_1_459_+ FIG00002034 123 17 124 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_r2_144832_1_459_+ FIG00000001 107 17 107 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_144869_193_459_- FIG00001189 34 6 35 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_r2_144873_1_417_+ FIG00004453 28 6 30 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_r2_144874_1_459_- FIG00000207 11 3 12 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_144888_1_330_+ FIG00000621 12 4 13 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_r2_144923_1_459_+ FIG00023943 117 18 117 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_r2_144937_1_394_- FIG00016061 80 13 81 L-lactate permease Lactate utilization 3 T2D_r2_144941_1_458_- FIG00000356 13 5 14 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_145030_158_458_+ FIG00058189 3 3 4 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_r2_145054_1_458_- FIG00000877 66 13 67 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_145073_1_458_+ FIG00005727 10 5 12 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_145104_1_458_+ FIG00000075 5 2 7 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_r2_145235_1_458_- FIG00006463 84 15 86 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_145282_1_337_- FIG00010414 94 13 94 ComF operon protein A, DNA transporter ATPase Gram Positive Competence 3100 T2D_r2_145340_1_386_+ FIG00001385 12 6 13 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_145345_1_458_+ FIG00000147 24 7 25 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_145377_77_457_+ FIG01260980 88 13 89 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_145483_1_298_- FIG00003580 14 3 15 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_145524_1_457_- FIG00000130 116 18 116 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_145592_1_457_+ FIG00035175 18 4 21 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_145596_1_457_- FIG00024401 14 4 15 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_145637_1_336_+ FIG00010600 10 3 12 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_r2_145650_1_457_+ FIG00000474 23 8 24 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_r2_145835_1_456_+ FIG00024073 24 5 25 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_145836_1_456_+ FIG00002920 37 10 38 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_r2_145889_1_456_+ FIG00000672 37 8 38 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_145894_1_456_- FIG00005860 8 2 9 SusD, outer membrane protein Cellulosome 1.x T2D_r2_145901_1_415_+ FIG00455853 27 8 29 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_145908_107_456_+ FIG00050603 58 11 59 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_146007_1_456_- FIG00018699 20 6 22 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_146027_1_456_- FIG00000038 28 8 29 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_146038_1_433_- FIG00006463 89 15 89 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_146042_1_456_- FIG00000289 5 2 6 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_r2_146058_1_456_+ FIG00000858 43 11 44 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_r2_146103_1_301_- FIG00000095 43 8 46 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_146117_1_369_+ FIG00000241 65 13 66 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_146155_1_456_- FIG00007079 30 8 32 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_146197_260_456_- FIG00023369 28 5 29 Chaperone protein DnaK Protein chaperones 2.0 T2D_r2_146208_59_456_- FIG00018369 16 4 18 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_146217_1_456_- FIG00003757 5 2 7 L-arabinose transport ATP-binding protein AraG (TC 3.A.1.2.2) L-Arabinose utilization 1 T2D_r2_146225_82_455_+ FIG00064110 17 6 19 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_146233_1_455_- FIG00041038 27 9 28 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_146238_49_455_+ FIG00000187 74 13 75 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_r2_146310_325_455_+ FIG00011102 16 3 16 Nitrite reductase probable electron transfer 4Fe-S subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_r2_146400_105_455_+ FIG00000279 94 14 94 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_146453_1_231_+ FIG00018396 52 9 52 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_146491_1_455_- FIG00000107 15 7 31 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_r2_146511_285_455_+ FIG00006609 26 5 26 Nickel transport ATP-binding protein NikE (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_r2_146536_1_455_+ FIG00051439 19 4 21 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_146568_1_188_+ FIG00018699 41 7 41 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_146570_1_444_+ FIG00002968 52 9 53 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_r2_146624_1_328_+ FIG00008348 91 13 91 Predicted transcriptional regulator of N-Acetylglucosamine utilization, GntR family Chitin and N-acetylglucosamine utilization 2 T2D_r2_146659_1_382_- FIG00000892 8 3 9 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_146687_167_454_- FIG00006092 62 10 62 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_146710_293_454_- FIG00000333 18 4 18 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_146741_165_341_+ FIG00000409 10 4 11 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_r2_146777_31_454_- FIG00000080 75 12 76 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_146813_1_382_+ FIG00000552 62 10 64 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_r2_146815_1_454_+ FIG00038920 111 16 112 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_r2_146850_93_454_- FIG00001011 3 2 4 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_r2_146858_1_454_- FIG00000102 91 16 93 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_146992_1_199_+ FIG00000101 14 4 16 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_r2_147019_1_427_+ FIG00012037 119 17 119 heterodisulfide reductase, iron-sulfur binding subunit, putative Anaerobic respiratory reductases 3 T2D_r2_147028_1_454_+ FIG00002689 6 3 8 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_147030_77_454_+ FIG00061313 60 9 61 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_r2_147111_266_453_+ FIG00000402 15 3 16 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_147138_1_453_- FIG00066643 11 4 13 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_147139_187_453_+ FIG00000402 26 5 28 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_147151_64_453_- FIG00000149 93 15 93 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_r2_147157_1_453_- FIG00028694 14 5 17 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_r2_147178_127_453_- FIG01031896 21 5 23 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_r2_147186_91_453_- FIG00011382 9 3 11 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_r2_147255_1_453_- FIG00083946 20 6 22 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_147288_1_453_+ FIG00000866 17 4 18 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r2_147330_1_453_+ FIG00010285 16 5 18 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_r2_147380_1_453_+ FIG00080955 25 9 26 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_147418_299_453_+ FIG00598409 14 3 15 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_r2_147475_1_453_- FIG00011659 98 15 98 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_r2_147520_1_452_- FIG00000212 15 4 17 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_r2_147604_1_216_- FIG00018561 50 7 50 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_147604_294_452_- FIG00010508 40 6 40 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_147606_267_452_+ FIG00028203 10 3 11 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_147625_1_452_- FIG00000107 66 10 68 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_r2_147635_134_452_- FIG00000088 54 11 54 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_147692_1_452_- FIG00139192 21 7 25 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_r2_147701_1_452_+ FIG00000356 37 7 40 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_147729_1_452_- FIG00001675 10 5 14 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_147764_1_138_+ FIG00459778 31 5 31 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_147792_1_452_- FIG00061313 44 10 46 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_r2_147818_1_452_- FIG00000121 83 16 84 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_r2_147821_1_452_+ FIG01007502 8 3 10 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_147854_1_452_+ FIG00006542 9 4 10 FIG006542: Phosphoesterase CBSS-257314.1.peg.676 4.x T2D_r2_147856_1_452_+ FIG00022899 71 16 72 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_147883_1_452_+ FIG00000414 98 16 99 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_r2_147889_1_452_+ FIG00561498 116 18 116 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_147918_1_452_- FIG01260980 9 6 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_147935_1_142_- FIG00000412 36 5 36 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_147935_211_452_- FIG00000282 3 3 6 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_147958_144_451_+ FIG00003555 3 3 4 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_147974_1_328_- FIG00019454 6 4 11 NrfD protein Nitrate and nitrite ammonification 1 T2D_r2_148002_1_451_+ FIG00001469 3 2 5 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_148014_1_451_+ FIG00030191 4 4 6 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_148039_1_451_+ FIG00054459 43 11 44 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_148103_1_451_+ FIG00004655 5 2 6 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_r2_148116_1_230_+ FIG00000210 54 9 54 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_r2_148132_1_302_+ FIG00000377 75 11 75 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_148138_16_451_- FIG00000184 17 6 19 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_148154_1_212_- FIG00000185 19 6 19 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_r2_148172_212_451_- FIG00000069 19 6 20 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_148179_187_451_- FIG00002968 38 7 38 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_r2_148213_100_451_- FIG00000341 33 9 34 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_148231_1_451_- FIG00000117 115 18 115 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_148262_1_215_- FIG00475203 3 2 4 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_r2_148270_24_451_- FIG00004074 96 16 96 Ferredoxin-type protein NapG (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_r2_148274_1_297_- FIG00016286 4 2 5 Ribosyl nicotinamide transporter, PnuC-like Cobalt-zinc-cadmium resistance 1.26 T2D_r2_148310_83_451_- FIG00000770 4 3 6 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_r2_148312_1_170_- FIG00000283 7 2 7 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_148348_1_451_+ FIG00002011 116 18 116 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_r2_148371_1_451_+ FIG00018369 39 9 40 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_148384_1_241_- FIG00000269 45 8 46 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_r2_148446_1_450_+ FIG00000404 89 15 94 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_r2_148503_166_450_+ FIG00121768 60 10 61 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_148521_1_302_- FIG00004074 9 2 10 Ferredoxin-type protein NapG (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_r2_148546_1_450_+ FIG00000116 10 3 11 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_148549_55_450_+ FIG00001818 52 9 53 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_r2_148565_1_389_+ FIG00000163 31 7 33 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_148572_1_450_- FIG00000402 24 7 27 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_148576_1_450_- FIG00001269 101 16 101 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_148613_1_450_- FIG00001269 22 4 25 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_148650_1_450_+ FIG01260980 20 8 22 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_148679_1_450_- FIG00000245 76 15 77 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_148785_149_450_- FIG00010818 27 7 29 L-serine dehydratase, beta subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_148786_1_450_- FIG00000402 21 5 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_148788_198_450_- FIG00034851 56 10 56 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_148796_1_450_- FIG00000552 12 3 14 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_r2_148845_1_449_- FIG00000539 45 10 46 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_148942_1_449_+ FIG00000242 89 16 90 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_148956_1_449_+ FIG00000476 15 5 16 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_148987_1_355_+ FIG00026006 5 2 7 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_148997_1_449_+ FIG00066575 5 2 6 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_149074_1_354_- FIG00048014 16 4 18 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_149182_280_449_+ FIG00000402 7 2 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_149184_1_449_+ FIG00000287 57 10 59 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_149217_1_243_+ FIG00003002 55 9 55 HtrA protease/chaperone protein Periplasmic Stress Response 1.1 T2D_r2_149240_1_256_+ FIG00009682 19 4 20 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_149274_47_229_+ FIG00000409 15 4 16 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_r2_149286_1_449_- FIG01318398 6 3 8 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_149304_106_448_- FIG00093180 10 4 12 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_149312_1_448_+ FIG00001518 18 5 19 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_r2_149315_1_448_+ FIG00031250 9 5 12 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_149364_147_448_- FIG01007502 31 6 31 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_149367_1_448_- FIG00022300 52 12 53 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_149378_236_448_- FIG00018561 20 6 22 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_149386_258_448_+ FIG00011468 39 6 41 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_r2_149409_1_448_+ FIG00000036 83 14 84 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_149483_222_448_+ FIG00034851 10 4 11 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_149489_1_448_+ FIG00000355 73 13 74 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_149519_1_448_+ FIG00000421 38 10 39 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_r2_149556_1_448_+ FIG00116638 10 5 13 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_r2_149565_1_448_- FIG00018369 17 5 18 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_149644_1_278_- FIG01304636 8 5 9 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_r2_149649_1_448_+ FIG00080231 36 8 37 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_r2_149652_1_448_+ FIG00000402 7 4 10 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_149666_1_448_+ FIG00000687 20 6 33 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_r2_149688_1_356_- FIG00000721 84 14 84 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_149712_1_448_- FIG00229386 49 11 51 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_149715_1_448_+ FIG00134135 94 15 95 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_r2_149730_100_448_+ FIG00000140 45 8 46 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_149812_1_447_- FIG00000113 102 16 103 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_149848_258_447_- FIG00000770 26 5 27 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_r2_149868_1_447_+ FIG00007079 17 4 18 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_r2_149904_1_447_+ FIG00002944 8 4 10 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_r2_149950_1_447_- FIG00000314 36 9 38 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_r2_149968_1_447_- FIG00041038 7 3 9 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_149994_1_284_+ FIG00019508 44 9 45 Phage major tail protein Phage tail proteins 2 4 T2D_r2_150006_1_198_- FIG00006463 40 7 40 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_150013_10_447_+ FIG00007339 47 9 49 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_r2_150065_1_447_+ FIG00136522 116 17 116 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_r2_150069_1_447_- FIG01260980 40 10 41 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_150071_1_447_- FIG00008507 3 2 4 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_r2_150091_1_447_+ FIG00000539 123 17 123 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_150162_1_447_+ FIG00000372 6 3 7 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_150277_1_264_- FIG00028461 6 3 7 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_150296_1_446_+ FIG00136692 31 7 32 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_150329_1_446_+ FIG00020363 120 17 120 ABC-type tungstate transport system, periplasmic binding protein ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_150406_1_446_- FIG01260980 3 2 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_150413_1_446_- FIG00001377 36 7 38 Pyruvate oxidase [ubiquinone, cytochrome] (EC 1.2.2.2) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_150424_1_251_+ FIG00000080 65 10 65 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_150424_269_446_+ FIG00000659 44 7 44 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_150434_1_446_- FIG00001548 17 5 19 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_150450_1_446_+ FIG00054459 48 9 50 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_150492_1_241_- FIG00001548 4 2 5 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_150495_187_446_- FIG00133292 3 3 4 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_150527_120_446_- FIG00035634 54 10 56 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_r2_150555_1_446_- FIG00000594 125 17 125 Chaperone protein HtpG Protein chaperones 2.0 T2D_r2_150560_1_446_- FIG00066425 3 3 6 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_r2_150583_1_446_- FIG00001824 23 8 25 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_150588_10_446_- FIG00474174 48 11 50 Tungsten-containing aldehyde:ferredoxin oxidoreductase (EC 1.2.7.5) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_150605_1_127_- FIG01318274 17 4 17 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r2_150609_60_446_+ FIG00001865 7 4 9 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_r2_150638_1_429_+ FIG00000038 52 11 54 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_150645_1_445_- FIG00136922 85 13 86 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_150659_1_360_- FIG00132666 10 7 12 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_150675_1_445_+ FIG00066425 17 7 18 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_r2_150740_1_246_+ FIG00001054 22 6 24 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_150750_1_445_- FIG00000450 115 17 115 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_150759_1_445_- FIG00003715 9 3 11 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_150771_102_445_- FIG00000032 7 3 9 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_150780_1_445_- FIG00001561 93 16 93 Probable GTPase related to EngC Universal GTPases 2 T2D_r2_150818_1_277_- FIG00010524 3 2 5 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_150828_1_237_+ FIG00001932 8 4 12 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_150898_1_349_+ FIG00002351 87 14 87 Predicted membrane fusion protein (MFP) component of efflux pump, membrane anchor protein YbhG ATP-dependent efflux pump transporter Ybh 1 T2D_r2_150921_1_445_+ FIG00002344 9 5 11 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r2_150929_1_445_+ FIG00341289 28 5 34 Prephenate dehydratase (EC 4.2.1.51) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_r2_150934_200_445_- FIG00000777 8 3 9 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_150956_1_375_+ FIG00000113 24 7 27 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_150960_1_229_+ FIG00007157 45 8 45 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_r2_150968_1_141_+ FIG00000312 5 2 6 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_r2_150995_36_445_- FIG00000097 91 14 91 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_151011_1_358_+ FIG00002255 80 12 80 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) Polyhydroxybutyrate metabolism 5.6 T2D_r2_151126_1_444_+ FIG00340292 86 16 87 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_151134_1_444_- FIG00000551 63 13 64 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_151227_1_290_- FIG00019652 36 7 37 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_r2_151235_1_444_- FIG00002011 103 15 103 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_r2_151240_1_444_- FIG00030191 104 16 104 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_151243_1_444_- FIG00000527 109 17 109 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_r2_151262_237_444_+ FIG00133515 32 5 33 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_151264_81_444_- FIG00000269 103 14 103 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_r2_151277_1_444_+ FIG00044622 105 16 105 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_151388_1_444_- FIG00042275 118 17 118 ABC transport system, permease component YbhR ATP-dependent efflux pump transporter Ybh 1 T2D_r2_151466_1_444_+ FIG00002300 51 10 53 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_r2_151506_1_443_- FIG00000132 35 8 37 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_151523_1_443_- FIG00000476 12 6 13 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r2_151543_153_443_+ FIG00000370 19 3 20 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_151552_1_150_- FIG00025759 17 3 18 Orotate phosphoribosyltransferase (EC 2.4.2.10) De Novo Pyrimidine Synthesis 1 T2D_r2_151552_272_443_+ FIG00000065 8 2 9 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_151554_1_443_+ FIG00066425 13 4 15 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_r2_151560_1_443_- FIG00000372 105 17 106 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_151594_1_443_- FIG00000139 117 16 117 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_151614_1_443_- FIG00000397 52 14 53 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_r2_151628_1_443_- FIG00000098 92 16 93 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_151646_247_443_- FIG00008507 51 7 51 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_r2_151687_1_443_+ FIG00041038 27 8 29 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_151689_1_443_- FIG00000402 125 17 125 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_151733_1_443_+ FIG00000372 25 6 26 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_151742_1_443_- FIG00000822 34 7 35 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_r2_151743_1_443_- FIG01260980 88 13 89 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_151844_1_443_- FIG00002050 43 10 44 Urease alpha subunit (EC 3.5.1.5) Urease subunits 1.x T2D_r2_151849_1_443_+ FIG01007502 16 6 21 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_151886_14_415_+ FIG00229386 6 4 7 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_151889_1_443_- FIG00168885 19 6 20 Cellobiose phosphorylase (EC 2.4.1.-) Beta-Glucoside Metabolism 2.bc T2D_r2_151942_1_443_- FIG00023946 13 6 14 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_151984_1_442_- FIG00001635 71 14 71 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_152037_1_442_+ FIG00000191 49 13 50 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_152043_1_218_- FIG00133209 53 8 53 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_r2_152060_1_442_+ FIG00055715 12 3 15 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_152144_1_442_- FIG00001469 4 4 15 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_152161_1_442_- FIG00011114 52 9 53 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_152193_1_216_+ FIG00000017 27 5 27 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_152193_219_442_+ FIG00000112 14 4 15 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_r2_152197_1_442_+ FIG00058830 66 13 68 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_152213_1_442_- FIG00008396 101 15 101 Aquaporin Z Osmoregulation 1 T2D_r2_152217_1_442_- FIG00002470 13 3 14 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_152238_1_242_+ FIG00003979 12 3 17 Putative sugar ABC transport system, ATP-binding protein YtfR (EC 3.6.3.17) Putative sugar ABC transporter (ytf cluster) 3.0 T2D_r2_152252_1_442_+ FIG00000348 103 15 104 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_r2_152280_1_442_+ FIG00006092 12 5 15 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_152299_1_221_+ FIG00002049 3 2 4 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_152347_1_442_- FIG00009068 12 4 15 RNA polymerase sigma factor for flagellar operon Transcription initiation, bacterial sigma factors 1 T2D_r2_152350_22_442_- FIG00000430 29 8 31 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_r2_152352_1_402_- FIG00093180 38 10 39 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_152355_1_442_+ FIG00007960 3 5 11 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_152362_1_442_+ FIG00000717 45 8 46 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_r2_152374_76_442_+ FIG00024401 19 7 25 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r2_152393_1_441_+ FIG00001268 86 15 87 Selenophosphate-dependent tRNA 2-selenouridine synthase Selenocysteine metabolism 1.1 T2D_r2_152423_1_441_+ FIG00000283 62 13 64 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_152449_1_441_- FIG00945384 6 3 7 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_152454_1_365_+ FIG00000207 21 4 22 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_152460_211_441_- FIG00047509 34 7 35 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_152478_216_441_- FIG00000521 6 2 7 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_r2_152480_1_232_+ FIG00002504 44 8 44 DNA-damage-inducible protein J Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_r2_152535_1_231_+ FIG00010818 7 2 8 L-serine dehydratase, beta subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_152541_1_441_- FIG00003433 103 17 103 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_r2_152569_1_441_- FIG00001635 19 7 20 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_r2_152573_313_441_+ FIG00000522 24 5 24 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_152580_1_222_- FIG00000080 6 2 7 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_152623_1_305_- FIG00007039 5 2 6 Multiple sugar ABC transporter, membrane-spanning permease protein MsmG Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_152652_1_441_- FIG00000380 58 11 59 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_152671_1_441_+ FIG00041038 16 7 18 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_152688_1_441_+ FIG01260980 90 15 91 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_152721_268_441_- FIG00000043 5 2 6 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_152745_1_441_- FIG00005237 19 9 22 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_r2_152759_129_441_- FIG00000838 5 2 7 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_152768_1_441_- FIG00000863 11 4 12 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_r2_152798_1_303_+ FIG00000412 11 4 13 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_152822_1_440_- FIG00000459 12 3 17 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_152831_1_440_- FIG00031250 27 8 28 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_152846_1_440_- FIG00138182 112 18 112 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_r2_152853_1_440_+ FIG00000522 95 16 95 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_152875_1_414_+ FIG00000333 22 7 25 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_152888_1_440_- FIG00623809 43 10 45 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_152898_1_440_+ FIG00000140 62 11 63 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_152913_1_440_- FIG00005992 15 3 16 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_152946_43_440_- FIG00340292 66 13 66 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_152948_1_440_- FIG01591039 90 14 92 Mlc, transcriptional repressor of MalT (the transcriptional activator of maltose regulon) and manXYZ operon Maltose and Maltodextrin Utilization 1.x T2D_r2_152983_1_440_- FIG00006463 10 4 14 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_153017_1_440_- FIG00000113 60 12 62 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_153019_124_440_+ FIG00000355 3 3 5 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_153022_1_440_+ FIG00000985 40 8 41 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_r2_153056_1_243_+ FIG00002239 65 9 65 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_153060_1_440_- FIG00000103 16 6 18 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_153061_1_440_- FIG00000304 22 5 23 GTP-binding protein HflX Hfl operon 1.111 T2D_r2_153076_1_440_- FIG00000673 30 8 33 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_r2_153087_8_440_- FIG00005237 4 2 5 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_r2_153091_1_399_- FIG00000102 30 6 31 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_153111_1_440_- FIG00038456 23 7 26 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_153122_1_440_+ FIG00000356 49 10 50 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_r2_153154_1_235_- FIG00001577 23 6 25 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_r2_153160_1_440_- FIG00004744 35 9 36 Rare lipoprotein A precursor Peptidoglycan Biosynthesis 1.9 T2D_r2_153248_1_366_- FIG00001819 8 2 11 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_r2_153336_1_282_- FIG00139150 3 2 5 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit B p-Aminobenzoyl-Glutamate Utilization 1 T2D_r2_153337_1_439_+ FIG00042267 16 6 17 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_r2_153345_112_439_- FIG00046929 22 5 23 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_153347_1_439_- FIG00001022 22 6 24 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_r2_153377_1_439_+ FIG00000445 59 12 61 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_r2_153385_1_154_- FIG00561498 24 5 24 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_153403_1_439_- FIG00000464 14 4 21 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_153429_1_439_- FIG00000450 69 13 70 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_153441_1_439_- FIG00136692 27 6 28 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_153446_1_439_- FIG00561498 7 3 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_153480_1_439_+ FIG00074196 29 8 31 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_r2_153487_1_280_+ FIG00034973 67 9 67 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_r2_153508_1_439_- FIG00007495 18 5 19 Spore maturation protein B Spore Core Dehydration 1.1 T2D_r2_153509_1_203_+ FIG00000301 11 3 12 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_r2_153560_1_439_- FIG00031250 102 16 102 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_153597_1_439_- FIG00000268 95 15 96 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_153620_1_236_- FIG00008370 63 9 63 Creatinine amidohydrolase (EC 3.5.2.10) Creatine and Creatinine Degradation 4.0 T2D_r2_153620_261_439_- FIG00451095 43 7 43 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_153660_1_439_+ FIG00000504 53 10 54 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_153663_23_439_- FIG00000025 92 15 92 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_153666_1_439_+ FIG01260980 13 4 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_153668_1_439_+ FIG00038343 14 3 15 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_r2_153671_1_439_+ FIG00008941 20 6 22 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_153674_1_439_+ FIG00001094 36 11 37 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_153676_1_439_- FIG00000539 25 8 26 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_153678_235_439_+ FIG00024930 51 8 51 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_r2_153680_1_439_- FIG00001676 10 4 12 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_153721_1_438_+ FIG00044478 26 9 28 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_r2_153725_130_438_- FIG00945384 12 4 14 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_153732_1_340_- FIG00006699 25 5 26 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_r2_153757_1_438_+ FIG00136922 113 17 113 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_153761_1_398_+ FIG00000263 59 12 60 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_r2_153796_1_438_+ FIG00079740 46 10 47 Xyloside transporter XynT Xylose utilization 1 T2D_r2_153804_146_438_+ FIG00000111 10 3 11 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_153849_1_438_- FIG00004078 93 14 94 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_153891_1_438_- FIG00000377 111 17 111 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_154049_1_438_- FIG00000911 17 6 18 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_154051_1_438_- FIG00138182 19 5 20 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_r2_154062_1_438_- FIG00000414 101 16 101 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_r2_154063_207_438_+ FIG00002130 9 2 10 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_154114_1_438_- FIG00001354 79 14 80 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_r2_154127_1_438_- FIG00000207 88 15 89 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_154165_107_437_+ FIG00000017 37 7 38 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_r2_154195_1_269_- FIG00002026 22 5 23 Nucleotidase YfbR, HD superfamily Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_154232_1_437_+ FIG00018369 112 17 112 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r2_154251_1_437_- FIG00000163 42 8 43 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_154262_1_437_+ FIG01260980 128 17 128 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_154266_1_437_- FIG00024073 123 17 123 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_154271_1_205_- FIG00000163 29 5 30 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_154271_273_437_- FIG00135554 27 6 28 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_r2_154279_1_142_+ FIG00000364 6 3 8 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) Coenzyme A Biosynthesis A.191 T2D_r2_154283_1_437_+ FIG01260980 126 17 126 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_154291_1_437_+ FIG00041382 120 17 120 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_154293_245_437_+ FIG00000420 9 3 10 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_r2_154302_1_405_- FIG00000985 13 4 15 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_r2_154312_1_437_+ FIG00000134 39 8 40 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_154315_58_437_- FIG00628860 25 6 27 Hypothetical protein Cj1505c Selenocysteine metabolism 1.1 T2D_r2_154320_1_437_+ FIG00095822 7 2 9 Pseudouridine kinase (EC 2.7.1.83) Pseudouridine Metabolism 9 T2D_r2_154349_1_437_+ FIG00018865 8 5 10 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_154355_1_437_+ FIG00003520 14 4 16 Phage tail fiber protein Phage tail fiber proteins 2 T2D_r2_154413_1_437_- FIG00040858 112 17 112 Additional periplasmic component NikK of nickel ECF transporter Transport of Nickel and Cobalt 7 T2D_r2_154441_196_437_+ FIG00000381 53 9 53 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_r2_154443_29_437_- FIG00049433 27 7 28 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_154459_1_345_+ FIG00000241 78 13 78 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_154477_1_437_+ FIG00008342 124 18 124 Anaerobic sulfite reductase subunit A Anaerobic respiratory reductases 3 T2D_r2_154484_1_437_+ FIG00000242 28 5 30 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_154494_61_437_+ FIG00076285 24 6 25 Substrate-specific component STY3230 of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_r2_154528_1_219_- FIG00000412 46 8 46 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_154528_238_437_- FIG00066425 47 8 47 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_r2_154530_1_437_+ FIG00048014 115 17 115 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_154540_1_398_+ FIG00012067 3 3 4 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_r2_154598_1_437_- FIG00018699 96 17 96 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_154603_1_437_+ FIG00000279 39 10 40 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_154611_1_437_+ FIG00016514 34 9 35 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_154627_50_437_- FIG00074225 96 14 96 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_154645_1_437_+ FIG00143531 102 16 102 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_r2_154647_1_185_- FIG00009149 34 6 34 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_154647_223_436_- FIG00002255 44 7 44 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) Polyhydroxybutyrate metabolism 5.6 T2D_r2_154655_1_436_- FIG00001548 31 8 33 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_154680_184_436_+ FIG00009229 44 9 45 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_r2_154706_145_436_+ FIG00001388 8 2 9 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_r2_154715_1_436_+ FIG00008736 13 4 16 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_154741_1_436_+ FIG00009265 62 11 64 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) Selenocysteine metabolism 1.1 T2D_r2_154843_1_436_+ FIG01318398 100 17 100 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_154864_1_436_+ FIG00038343 17 5 18 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_r2_154871_209_436_+ FIG00002974 42 7 42 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_r2_154894_1_436_+ FIG00000777 42 9 44 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_r2_154902_1_282_+ FIG00001893 5 2 6 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_r2_154919_1_436_+ FIG00129616 12 5 13 GTP-binding protein EngA Universal GTPases 2 T2D_r2_154920_1_157_+ FIG00000372 36 6 36 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_154927_1_436_- FIG00017190 66 13 69 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_154932_1_253_+ FIG00047056 34 6 35 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_r2_154991_1_436_- FIG00010600 47 10 48 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_r2_155027_202_436_- FIG00000191 8 3 10 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_155036_1_436_- FIG00025216 40 10 41 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_155040_1_436_+ FIG00000659 7 3 10 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_155103_1_436_- FIG00002049 63 12 63 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_155135_1_214_- FIG00000190 6 2 7 Recombination protein RecR DNA processing cluster 1.1 T2D_r2_155135_218_435_- FIG00000557 7 4 9 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_r2_155199_170_435_+ FIG00007941 3 2 5 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_r2_155224_1_435_+ FIG01304636 27 7 29 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_r2_155236_1_435_- FIG00132586 58 14 59 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_r2_155246_274_435_+ FIG00000203 11 2 12 SSU ribosomal protein S12p (S23e) Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_155250_1_148_- FIG00085033 23 5 24 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_r2_155250_232_435_- FIG00000221 49 7 49 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_155256_1_422_+ FIG00000245 40 9 42 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_155276_1_418_+ FIG00019415 10 3 11 Putative activity regulator of membrane protease YbbK CBSS-316057.3.peg.659 1 T2D_r2_155318_1_435_+ FIG01955844 74 10 75 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_155320_175_435_- FIG01266244 17 5 19 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_r2_155326_1_216_- FIG00001548 30 6 31 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_155329_1_435_- FIG00008941 44 8 47 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_155343_1_435_+ FIG00026146 99 15 99 Di/tripeptide permease DtpA Proton-dependent Peptide Transporters 1 T2D_r2_155345_1_299_+ FIG00229216 24 6 25 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_155353_1_435_+ FIG00006151 72 14 82 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_155368_1_197_- FIG00000482 6 2 7 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_155371_43_435_+ FIG00000095 23 7 24 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_155441_1_435_- FIG00001871 117 17 117 Glycerol-3-phosphate ABC transporter, permease protein UgpE (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_155454_1_421_- FIG00000001 19 7 21 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_155469_1_435_+ FIG00000402 31 7 33 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_155485_264_435_- FIG00133209 14 3 15 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_r2_155502_1_266_+ FIG00046929 14 4 15 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_155519_1_435_- FIG01260980 25 7 27 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_155530_1_435_- FIG00080231 10 4 12 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_r2_155552_1_434_- FIG00000716 14 4 16 Homoserine O-acetyltransferase (EC 2.3.1.31) Methionine Biosynthesis 8 T2D_r2_155587_132_434_- FIG00000111 9 3 11 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_155603_1_434_- FIG00000402 101 16 102 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_155611_1_218_+ FIG00006551 7 3 8 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_155639_137_434_- FIG00001088 73 11 73 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_155645_1_362_+ FIG00000038 15 4 17 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r2_155665_15_434_+ FIG00001676 46 9 48 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_155684_1_164_- FIG01290653 14 2 15 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_155685_1_434_+ FIG00076542 125 17 125 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_r2_155700_282_434_+ FIG00000070 6 3 7 Chaperone protein DnaJ Protein chaperones 2.0 T2D_r2_155733_1_434_- FIG00028203 19 8 24 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_155764_1_434_- FIG00000036 27 9 28 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_r2_155770_1_434_+ FIG00000636 64 12 65 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_155825_98_434_- FIG00008556 35 8 43 L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_155844_41_434_+ FIG00001364 88 13 88 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Glycine and Serine Utilization 1.12 T2D_r2_155867_1_434_- FIG00000111 56 13 57 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_155879_225_434_- FIG00000032 51 8 51 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_155895_1_434_- FIG00000287 102 15 102 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_155902_1_434_- FIG00004078 16 6 17 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_155921_1_434_+ FIG00000317 14 4 16 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_155944_217_434_+ FIG00132839 46 8 47 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_155951_12_317_- FIG00010675 4 4 7 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_r2_155966_1_434_- FIG00034293 59 13 60 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_155987_1_434_- FIG00006151 39 11 41 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_156008_1_434_+ FIG00007960 27 7 29 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_156116_1_170_+ FIG00000402 10 3 11 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_156185_1_433_- FIG00006151 23 6 24 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_156200_1_213_- FIG00000025 9 2 10 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_156206_1_191_- FIG00000193 51 7 51 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_r2_156219_1_320_+ FIG01031896 10 3 12 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_r2_156257_121_433_- FIG01007502 7 2 8 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_156288_1_360_+ FIG00007960 4 2 5 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_156353_1_242_+ FIG00046358 7 4 8 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_156379_1_433_+ FIG00008708 88 14 89 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_r2_156405_1_433_+ FIG00000329 35 7 36 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r2_156406_168_433_+ FIG00136922 60 10 60 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_156518_1_432_- FIG00135469 8 3 9 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_r2_156528_1_432_+ FIG00138258 101 17 101 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_156583_1_432_- FIG00016514 29 7 31 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_156628_229_432_- FIG00004271 30 6 31 Cell division protein DivIC Cell division-ribosomal stress proteins cluster 1 T2D_r2_156653_1_432_- FIG00000522 27 7 29 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_156713_127_432_+ FIG00003472 21 5 22 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_156729_20_432_+ FIG00041038 41 9 42 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_156743_43_255_- FIG00004100 4 2 5 Cold shock protein CspA Cold shock, CspA family of proteins 1 T2D_r2_156770_1_432_+ FIG00006868 12 4 13 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_r2_156810_1_432_+ FIG00003535 125 17 125 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_156820_1_432_+ FIG00001269 121 17 121 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_156862_1_432_+ FIG01306479 7 3 9 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_156895_1_432_+ FIG00009149 6 4 8 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r2_156900_1_432_- FIG00080955 14 6 16 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_156930_1_431_+ FIG00092725 6 2 8 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Anaerobic respiratory reductases 3 T2D_r2_156938_1_431_- FIG00000268 51 10 52 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_r2_156962_1_235_- FIG00000084 43 8 44 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_r2_157019_60_431_- FIG00000986 26 7 27 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_r2_157035_1_431_- FIG00003387 76 15 76 ABC transporter multidrug efflux pump, fused ATP-binding domains ATP-dependent efflux pump transporter Ybh 1 T2D_r2_157037_1_180_- FIG00000877 12 4 13 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_157069_1_431_- FIG00002588 7 4 9 Formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) One-carbon metabolism by tetrahydropterines 5 T2D_r2_157078_1_431_+ FIG00000672 35 7 37 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_157104_299_431_- FIG00000028 18 3 19 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r2_157109_1_183_+ FIG00000548 10 4 12 3-polyprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_r2_157110_1_265_+ FIG00006151 9 4 10 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_157113_249_431_- FIG00000114 18 5 19 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_157135_1_431_- FIG00001209 11 4 12 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_r2_157137_1_431_- FIG00000011 33 7 35 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_157139_231_431_- FIG00047414 15 3 16 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_157143_1_431_+ FIG00006699 15 6 17 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_r2_157160_1_431_+ FIG00000775 24 6 25 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_157165_1_431_- FIG00000309 10 3 11 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_r2_157188_1_152_- FIG00000636 7 2 8 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_157231_1_246_+ FIG00034392 12 4 13 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_r2_157268_1_431_- FIG00055715 109 17 109 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_157295_1_431_- FIG00229257 39 8 40 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_r2_157321_1_431_+ FIG00047414 46 10 47 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_157330_1_431_+ FIG00000402 11 3 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_157336_1_431_- FIG00001530 6 2 8 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_r2_157343_1_431_- FIG00000445 42 11 43 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_r2_157359_190_431_+ FIG00000216 36 7 37 LSU ribosomal protein L20p Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins) 1 T2D_r2_157381_14_431_+ FIG00000370 65 12 66 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_157401_1_360_- FIG00052647 69 10 73 N-carbamoylsarcosine amidase (EC 3.5.1.59) Creatine and Creatinine Degradation 4.0 T2D_r2_157419_1_430_+ FIG00000287 3 2 6 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_157426_1_430_- FIG00000032 29 7 30 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_157447_1_430_+ FIG00004788 12 5 13 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_r2_157469_246_430_+ FIG00008736 9 3 10 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_157480_1_418_+ FIG00067681 55 13 56 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_157486_1_430_- FIG00453259 46 12 47 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_r2_157537_59_430_- FIG00002716 14 4 16 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_r2_157538_1_170_+ FIG00005237 39 6 39 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_r2_157538_180_430_+ FIG00002239 60 9 60 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_157551_1_430_- FIG00006151 7 3 9 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_157589_97_430_- FIG00031250 20 5 22 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_157614_230_430_- FIG00058830 10 4 11 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_157646_1_430_+ FIG00132839 29 7 31 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_157662_1_430_- FIG00008490 6 3 9 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_157672_1_130_+ FIG00000202 6 2 7 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_r2_157678_1_430_+ FIG00034293 55 13 56 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_157715_215_430_- FIG00000341 16 6 17 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_157737_1_378_+ FIG00005237 24 6 25 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_r2_157826_1_430_- FIG00003460 124 17 124 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_157853_1_429_+ FIG00000312 18 6 20 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_r2_157895_157_429_- FIG00007960 3 2 4 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_157903_300_429_+ FIG00000190 22 4 25 Recombination protein RecR DNA processing cluster 1.1 T2D_r2_157917_78_429_- FIG00003955 17 4 19 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_r2_157924_1_400_+ FIG00000328 79 15 79 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_r2_157925_1_313_- FIG00001388 76 12 76 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_r2_157928_50_429_+ FIG00041382 98 14 98 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_157957_1_342_- FIG00005111 11 3 13 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_r2_157982_1_429_+ FIG00133209 75 13 76 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_r2_158026_1_429_+ FIG00130344 35 9 36 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_158053_174_429_+ FIG00003580 3 2 4 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_158087_1_384_+ FIG00052943 32 6 34 Glycerol-3-phosphate transporter Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_158090_1_429_+ FIG00028203 85 15 86 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_158122_1_429_- FIG01307369 4 2 5 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) Cellulosome 1.x T2D_r2_158171_1_429_+ FIG00598409 127 17 127 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_r2_158187_1_429_+ FIG00001547 8 3 9 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_r2_158217_1_380_- FIG01255877 13 5 15 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_r2_158271_200_429_+ FIG00451095 4 2 6 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_158327_1_428_- FIG00001548 37 9 40 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_158346_1_428_- FIG00018699 113 17 113 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_158365_232_428_- FIG01954097 3 2 4 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_158387_1_428_+ FIG00000402 19 7 20 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_158395_22_428_+ FIG00000025 4 3 5 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_158418_1_428_- FIG00021289 110 17 110 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_158423_1_299_+ FIG00003394 77 12 77 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_r2_158441_1_374_- FIG00001548 36 9 37 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_158445_1_428_- FIG00000040 74 14 75 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r2_158471_1_410_+ FIG00004410 69 14 70 Aspartate racemase (EC 5.1.1.13) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_158490_9_428_+ FIG00012531 3 2 5 TRAP-type transport system, small permease component, predicted N-acetylneuraminate transporter Sialic Acid Metabolism 1.x T2D_r2_158527_1_294_- FIG00001753 7 2 9 Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-) Acetoin, butanediol metabolism 5 T2D_r2_158543_1_428_+ FIG00000402 91 15 91 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_158576_207_428_+ FIG00001044 58 8 58 Respiratory nitrate reductase alpha chain (EC 1.7.99.4) Nitrate and nitrite ammonification 1 T2D_r2_158588_98_428_- FIG00003433 71 11 72 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_r2_158591_1_428_- FIG00063189 35 9 37 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_r2_158636_1_428_- FIG00000025 19 6 20 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_158652_1_428_- FIG00080231 105 15 105 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_r2_158731_1_428_- FIG00041382 114 17 114 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_158753_59_428_- FIG01303866 55 10 57 DNA repair exonuclease family protein YhaO DNA repair, bacterial 3 T2D_r2_158760_1_428_- FIG00007960 11 4 13 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_158785_99_428_- FIG00005479 4 3 8 Transcriptional repressor for NAD biosynthesis in gram-positives NAD and NADP cofactor biosynthesis global E T2D_r2_158810_1_266_+ FIG00000367 48 8 48 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_r2_158810_293_427_+ FIG00000242 33 5 33 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_158818_24_427_+ FIG00038920 29 8 31 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_r2_158852_1_247_+ FIG00002026 11 3 12 Nucleotidase YfbR, HD superfamily Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_158880_1_275_- FIG00000350 63 10 65 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_158935_1_427_+ FIG00000089 104 16 105 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_r2_158971_198_427_+ FIG00473043 10 4 11 Similar to CDP-glucose 4,6-dehydratase (EC 4.2.1.45) Acetoin, butanediol metabolism 5 T2D_r2_159049_1_427_- FIG00067681 56 10 57 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_159074_171_427_+ FIG00000191 39 8 40 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_r2_159113_1_251_+ FIG00000482 7 2 8 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_r2_159138_1_427_- FIG00000863 7 2 8 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_r2_159195_110_427_+ FIG00091606 7 2 8 Methionine synthase activation domain (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_159202_1_427_+ FIG00000474 23 5 25 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_r2_159229_1_427_- FIG00002354 48 11 49 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_r2_159234_1_427_- FIG00009194 22 4 23 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_159244_1_341_+ FIG00000642 90 13 91 Spermidine synthase (EC 2.5.1.16) Polyamine Metabolism 2 T2D_r2_159343_1_426_- FIG00028461 29 7 30 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_159366_1_426_+ FIG00009971 9 3 10 Lipoprotein releasing system transmembrane protein LolC Lipoprotein sorting system 3 T2D_r2_159382_1_426_+ FIG00000370 115 17 115 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_159485_1_380_+ FIG00001378 30 7 31 N-carbamoylputrescine amidase (3.5.1.53) Polyamine Metabolism 2 T2D_r2_159500_1_426_+ FIG01304860 103 16 103 [Ni/Fe] hydrogenase, group 1, small subunit Hydrogenases 2 T2D_r2_159506_1_370_- FIG00003788 4 3 7 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_159513_1_426_+ FIG00000539 43 11 45 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_159516_1_426_- FIG00000207 13 4 15 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_159552_1_359_- FIG00000117 17 5 19 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_r2_159555_1_426_- FIG00004172 88 15 88 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_r2_159559_1_426_+ FIG00010771 88 16 88 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_159609_1_426_- FIG00006151 105 16 105 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_159626_95_426_- FIG00010508 12 3 15 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_159628_1_426_- FIG00138993 5 2 7 polysulfide reductase, subunit C Anaerobic respiratory reductases 3 T2D_r2_159632_141_426_+ FIG00003580 30 6 31 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_159635_252_426_- FIG00066280 36 6 36 V-type ATP synthase subunit G (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_159638_1_426_- FIG00341289 10 4 11 Prephenate dehydratase (EC 4.2.1.51) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_r2_159640_33_426_+ FIG01305829 4 2 7 N-Acetyl-D-glucosamine permease 2, possible Chitin and N-acetylglucosamine utilization 2 T2D_r2_159642_1_426_+ FIG01260980 118 17 118 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_159658_151_426_+ FIG00000241 68 10 68 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_159710_1_426_- FIG00132839 43 8 44 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_159737_1_238_+ FIG00000184 10 5 11 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_159764_168_425_+ FIG00130344 19 5 20 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_159790_1_425_+ FIG00000368 17 5 19 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_r2_159823_1_425_+ FIG00459778 32 9 34 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_159827_1_374_- FIG00010454 6 4 8 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_159868_1_425_+ FIG00016110 19 7 22 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_159874_200_425_- FIG00001522 5 2 7 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_r2_159879_1_425_+ FIG00016061 21 8 23 L-lactate permease Lactate utilization 3 T2D_r2_159887_1_266_+ FIG00000156 32 6 34 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_159890_1_214_- FIG00000011 44 7 44 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_159909_1_385_- FIG00018536 109 15 109 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_159920_1_425_- FIG00136692 26 6 29 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_159984_1_336_+ FIG00000156 31 7 32 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_160058_1_425_- FIG00038814 12 4 14 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_r2_160165_1_425_- FIG00046358 21 4 23 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_r2_160186_98_425_- FIG00022899 11 5 14 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_160250_1_424_- FIG00001647 4 2 6 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_r2_160256_1_424_- FIG00001871 3 2 4 Glycerol-3-phosphate ABC transporter, permease protein UgpE (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_160284_1_218_- FIG00000364 6 2 7 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) Coenzyme A Biosynthesis A.191 T2D_r2_160298_71_424_+ FIG00451095 3 2 5 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_160353_1_424_- FIG00006336 110 16 115 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_r2_160386_55_424_- FIG00001020 12 4 14 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_160413_1_424_- FIG01956356 47 10 49 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_r2_160425_1_424_- FIG00001670 9 5 11 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_r2_160446_1_424_- FIG00001548 7 3 8 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_160451_1_424_+ FIG00000372 9 4 12 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_160452_1_424_+ FIG00041038 59 12 61 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_160465_1_141_+ FIG00000088 3 2 4 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_160475_1_424_+ FIG00004170 87 13 88 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_r2_160557_1_424_- FIG00000721 21 6 23 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_160563_79_424_+ FIG00000341 63 12 63 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_160573_1_424_- FIG00136866 10 5 14 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_r2_160574_1_424_+ FIG00041038 109 16 109 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_160618_194_424_+ FIG00018201 3 2 4 HflC protein Hfl operon 1.111 T2D_r2_160627_1_424_- FIG00000401 71 13 72 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_160664_1_213_- FIG00621884 14 3 15 Hydrogenase maturation protease (EC 3.4.24.-) Hydrogenases 2 T2D_r2_160664_216_424_- FIG00066123 59 8 59 Ni,Fe-hydrogenase I cytochrome b subunit Hydrogenases 2 T2D_r2_160667_1_424_+ FIG00018396 25 7 27 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_r2_160669_1_172_+ FIG00000435 15 4 16 Exodeoxyribonuclease VII small subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_160689_1_424_+ FIG00135469 17 8 21 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_r2_160750_1_423_+ FIG00023369 81 13 82 Chaperone protein DnaK Protein chaperones 2.0 T2D_r2_160800_1_423_+ FIG00046929 107 17 107 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_160896_5_423_- FIG00088996 4 3 5 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_r2_160924_1_172_- FIG01304636 30 5 31 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_r2_160926_1_423_- FIG00002251 20 6 22 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_160941_251_423_+ FIG00003881 12 2 13 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_r2_160942_1_423_+ FIG00000521 13 7 15 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_r2_160952_1_423_+ FIG00003472 58 11 60 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_160964_1_423_- FIG00000793 19 8 22 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_161005_202_423_- FIG00000261 24 5 25 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_r2_161055_1_423_- FIG00000372 96 16 96 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_161060_1_423_+ FIG00007658 3 2 4 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_r2_161159_1_423_+ FIG00000025 5 3 6 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_161171_1_422_- FIG00001469 17 7 19 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_161175_1_422_+ FIG00000441 84 15 85 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_r2_161194_1_345_+ FIG00002541 41 9 43 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_r2_161294_1_422_+ FIG00130900 13 4 16 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_r2_161299_259_422_- FIG00028203 17 3 18 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_161310_1_422_+ FIG00004027 44 8 45 CoB--CoM heterodisulfide reductase subunit B (EC 1.8.98.1) Anaerobic respiratory reductases 3 T2D_r2_161319_1_422_+ FIG00046929 6 4 7 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_r2_161391_163_422_- FIG00003212 6 2 7 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_r2_161414_1_422_- FIG00000402 103 16 103 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_161440_1_422_+ FIG00002130 4 2 5 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_161468_1_379_- FIG00000163 14 5 16 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_r2_161473_1_422_+ FIG00058830 40 8 41 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_161476_1_422_- FIG00002344 15 4 16 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r2_161484_1_422_- FIG00132617 11 5 13 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_161492_11_422_+ FIG00000387 41 12 42 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_r2_161586_154_422_- FIG00000388 12 4 13 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_r2_161628_1_421_- FIG00000011 6 2 8 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_161642_34_421_- FIG00010134 36 8 37 Methionine transporter MetT Methionine Degradation 3 T2D_r2_161688_1_421_+ FIG00000147 40 10 42 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_161739_1_421_+ FIG00051439 121 17 121 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_161751_1_421_+ FIG00001647 118 17 118 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_r2_161782_1_421_+ FIG00001062 20 5 22 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_r2_161831_109_421_+ FIG00002034 87 12 87 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_r2_161849_1_168_+ FIG00093180 6 2 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_161872_270_421_+ FIG00004506 12 4 14 Lactate-responsive regulator LldR in Enterobacteria, GntR family Lactate utilization 3 T2D_r2_161878_1_421_+ FIG00031250 17 6 18 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_161886_165_421_+ FIG00000245 7 3 8 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_161906_1_421_+ FIG00340292 7 3 9 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_r2_161956_1_421_+ FIG00138018 4 4 6 Alpha-glucosidase SusB (EC 3.2.1.20) Cellulosome 1.x T2D_r2_161991_1_421_- FIG00000184 27 7 29 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_161996_1_421_+ FIG00016768 12 5 13 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_162019_1_154_- FIG00059211 16 4 16 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_162031_1_332_+ FIG00132617 6 3 8 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_162036_1_214_+ FIG00139117 45 7 45 Putative phosphatase YqaB 2-phosphoglycolate salvage 1 T2D_r2_162057_134_421_- FIG00000433 59 9 60 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_r2_162072_1_420_- FIG00000130 102 16 102 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_162077_1_386_+ FIG00002273 53 12 54 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_r2_162082_1_384_+ FIG00067248 41 10 43 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_162125_1_420_+ FIG00041382 79 12 80 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_162192_1_420_+ FIG00132839 36 7 37 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_162200_1_293_+ FIG00132994 73 11 73 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_r2_162231_1_420_+ FIG00133515 16 5 17 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_r2_162251_1_349_- FIG00018699 4 3 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_162266_1_420_+ FIG00028461 31 6 32 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_162291_145_420_- FIG00008562 8 3 14 Inositol transport system permease protein Inositol catabolism 5.x T2D_r2_162294_1_420_+ FIG00000146 73 14 74 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_162336_1_420_- FIG00000147 25 6 27 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_162344_1_408_- FIG00049336 17 6 18 Foldase protein PrsA precursor (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_r2_162370_1_420_- FIG00064110 54 13 55 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_162423_1_420_+ FIG00011537 3 2 6 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_162429_1_246_- FIG00000081 56 8 56 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r2_162443_1_211_+ FIG00003435 22 6 23 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_162476_274_420_+ FIG00007960 16 4 16 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_r2_162524_1_419_+ FIG00000395 9 3 10 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_r2_162551_1_221_+ FIG00044735 49 8 49 Aminopeptidase S (Leu, Val, Phe, Tyr preference) (EC 3.4.11.24) EC 3.4.11.- Aminopeptidases 1 T2D_r2_162617_1_224_- FIG00089707 4 3 5 Outer membrane protein H precursor Periplasmic Stress Response 1.1 T2D_r2_162623_1_419_- FIG00089781 6 3 8 Possible alpha-xyloside ABC transporter, permease component Xylose utilization 1 T2D_r2_162647_1_419_- FIG00079740 37 10 38 Xyloside transporter XynT Xylose utilization 1 T2D_r2_162681_45_383_- FIG00007256 80 13 80 FIG139598: Potential ribosomal protein CBSS-176279.3.peg.868 1.x T2D_r2_162700_1_419_+ FIG01260980 14 5 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_162743_1_419_- FIG00049433 11 4 14 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_162759_1_419_- FIG00001548 69 11 70 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_162794_1_419_+ FIG00109688 68 12 69 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_r2_162828_1_419_+ FIG00001067 20 6 21 Rubrerythrin Oxidative stress 1.2 T2D_r2_162831_107_419_- FIG00000088 39 9 41 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_162845_1_419_+ FIG00000011 36 8 37 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_162878_93_419_- FIG00018865 18 6 19 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_162941_1_419_- FIG00001166 115 16 115 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_163031_116_419_- FIG00000401 22 6 25 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_163039_24_418_- FIG00719736 7 3 10 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_163044_1_418_+ FIG00019251 59 10 60 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_163065_1_330_+ FIG00140555 70 12 70 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_163125_80_418_+ FIG00001642 5 3 7 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_163169_1_418_+ FIG00135025 36 8 38 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_163222_164_418_+ FIG00048580 9 3 10 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_r2_163230_1_418_+ FIG00017186 9 3 14 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK Dihydroxyacetone kinases 3 T2D_r2_163283_25_418_+ FIG01007502 6 3 9 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_163309_1_418_- FIG00011468 8 5 10 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_r2_163346_254_418_+ FIG01959601 29 5 29 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_r2_163373_1_301_- FIG00135315 79 12 79 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_r2_163379_1_418_- FIG00003672 14 5 16 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_r2_163382_1_418_+ FIG01298199 3 2 5 Transmembrane component STY3231 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_r2_163537_1_417_- FIG00000465 104 16 104 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_r2_163538_1_245_+ FIG00001361 41 6 41 Selenide,water dikinase (EC 2.7.9.3) Selenocysteine metabolism 1.1 T2D_r2_163554_1_417_+ FIG00034293 81 13 82 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_163573_1_417_+ FIG00001882 104 16 105 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_r2_163580_1_417_+ FIG00041382 112 16 112 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_163620_1_417_+ FIG00000532 53 11 55 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r2_163779_92_417_- FIG00000157 10 4 11 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_163780_268_417_- FIG00133143 38 5 38 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) Cysteine Biosynthesis 2.17 T2D_r2_163793_133_417_- FIG00000032 24 5 26 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_r2_163814_1_417_- FIG00001366 25 6 31 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_r2_163861_1_417_+ FIG00001094 56 11 57 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_163869_1_417_- FIG00000522 5 4 8 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_163896_1_417_- FIG00020897 33 7 35 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_r2_163903_1_176_- FIG00001980 6 3 7 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_r2_163935_1_417_+ FIG00146593 11 4 15 DegV family protein in cluster with TrmH family tRNA/rRNA methyltransferase YacO Conserved gene cluster possibly involved in RNA metabolism 1 T2D_r2_163938_105_417_- FIG00000552 14 3 17 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_r2_163955_283_417_+ FIG00000279 12 2 13 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_163958_1_154_+ FIG00869624 25 5 25 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_r2_163997_1_171_+ FIG00044622 10 3 11 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_164025_1_416_- FIG00000221 26 6 28 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_r2_164058_1_416_- FIG00070611 90 14 90 Phosphonate ABC transporter permease protein phnE1 (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_r2_164108_33_371_+ FIG00001088 3 2 5 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_r2_164126_1_416_+ FIG00052730 19 7 21 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_r2_164188_1_416_+ FIG00022996 8 3 9 Aconitate hydratase (EC 4.2.1.3) Serine-glyoxylate cycle 1 T2D_r2_164203_1_274_+ FIG00000762 66 10 66 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_r2_164256_1_416_- FIG00019251 11 3 14 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_164271_1_227_+ FIG00000283 4 3 6 DNA repair protein RadA DNA repair, bacterial 3 T2D_r2_164276_1_250_- FIG00000897 56 9 57 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_r2_164279_1_416_+ FIG00003472 50 10 51 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_r2_164322_1_416_- FIG00041038 30 11 31 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_164368_1_416_+ FIG00000279 14 5 15 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_r2_164377_1_164_- FIG00052802 36 6 36 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_r2_164382_1_416_- FIG00005992 3 2 4 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_164412_252_416_+ FIG00000065 41 6 41 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_164420_1_416_- FIG00018536 5 3 8 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_164424_1_416_+ FIG00002002 37 7 38 Ascorbate-specific PTS system, EIIC component L-ascorbate utilization (and related gene clusters) 29 T2D_r2_164441_1_416_+ FIG00000773 81 15 87 Glutamyl-tRNA synthetase (EC 6.1.1.17) tRNA aminoacylation, Glu and Gln 3.01 T2D_r2_164453_1_416_- FIG00000899 12 7 23 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_r2_164465_1_415_+ FIG00000126 100 15 101 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_164466_1_395_+ FIG00130344 48 9 49 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_164484_136_415_+ FIG00000241 10 3 11 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_r2_164490_189_415_- FIG00006151 13 5 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_r2_164496_1_415_+ FIG00000001 20 6 21 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_164508_1_415_+ FIG00012692 3 2 6 Site-specific tyrosine recombinase Proteasome bacterial 1 T2D_r2_164553_157_415_- FIG00003712 65 9 65 Fe-S-cluster-containing hydrogenase components 1 Anaerobic respiratory reductases 3 T2D_r2_164557_1_203_- FIG00000756 17 4 18 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_r2_164585_1_415_+ FIG00000209 63 12 64 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_r2_164590_1_415_+ FIG00011537 4 2 6 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_r2_164638_230_415_+ FIG00000402 16 3 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_164692_1_415_+ FIG00000168 112 16 112 Transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_164696_1_415_- FIG00018699 74 12 78 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_164730_1_415_- FIG00002560 4 3 5 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_164760_1_415_+ FIG01260980 35 8 37 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_164763_1_197_- FIG00138613 46 7 46 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.13.3) Aromatic Amin Catabolism 7 T2D_r2_164779_1_415_+ FIG00016110 58 14 59 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_164790_68_415_- FIG00000412 84 13 84 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_r2_164817_1_415_+ FIG00009194 21 7 22 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_164890_1_345_- FIG00000187 59 10 60 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_r2_164901_1_415_+ FIG00017190 9 4 11 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_r2_164920_1_414_+ FIG00001522 107 16 107 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_r2_164931_213_414_+ FIG00016663 17 3 19 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_r2_164942_269_414_- FIG00048580 6 2 8 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_r2_165013_1_414_+ FIG00059211 36 6 37 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r2_165023_1_414_+ FIG00093180 121 16 121 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_165037_76_414_- FIG00010844 45 8 46 Flavodoxin Flavodoxin 1 T2D_r2_165044_1_414_- FIG00004917 13 4 14 Protein AraJ precursor L-Arabinose utilization 1 T2D_r2_165049_1_414_- FIG00000721 9 2 11 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r2_165059_1_357_+ FIG00006117 11 3 12 Agmatine/putrescine antiporter, associated with agmatine catabolism Polyamine Metabolism 2 T2D_r2_165063_1_414_- FIG00000043 68 12 69 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_165093_1_414_- FIG00000157 34 9 36 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_165105_109_414_+ FIG00001253 89 12 89 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_r2_165118_1_414_+ FIG00000358 106 17 106 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_r2_165152_1_414_+ FIG00000147 33 11 34 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_165155_44_414_- FIG00016888 18 7 19 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_r2_165163_1_414_+ FIG00017454 7 3 13 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_165181_1_414_+ FIG00028203 109 16 109 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_165277_1_414_+ FIG00000147 31 7 33 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_r2_165291_1_167_- FIG00001067 12 4 12 Rubrerythrin Oxidative stress 1.2 T2D_r2_165318_1_414_- FIG00000301 44 10 46 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_r2_165340_1_282_- FIG00000672 60 10 60 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_r2_165347_1_414_- FIG01276112 7 2 12 Xylose ABC transporter, permease component Xylose utilization 1 T2D_r2_165358_1_248_+ FIG00063189 19 5 20 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_r2_165363_1_391_+ FIG00000659 6 4 8 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r2_165368_1_256_- FIG00010454 39 7 40 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_r2_165378_136_345_- FIG00002958 14 4 16 FIG002958: hypothetical protein Hypothetical Coupled to RecF 1 T2D_r2_165397_1_172_+ FIG00020613 28 5 28 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_r2_165417_1_413_+ FIG00000380 28 7 29 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r2_165464_48_413_+ FIG00002689 21 6 23 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_165508_1_294_- FIG00003460 21 6 22 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_r2_165511_1_413_- FIG00000080 44 12 65 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_165515_1_413_- FIG00001094 104 15 104 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_165603_1_413_- FIG00002320 91 14 91 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_r2_165605_1_413_- FIG00000402 109 16 109 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_165616_1_413_+ FIG00106663 4 2 5 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_165621_231_413_- FIG00000990 47 7 47 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_165622_94_413_+ FIG00075702 72 12 72 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_165653_1_413_- FIG00048014 99 15 99 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_165655_1_413_- FIG00075702 54 12 55 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_165663_1_413_+ FIG00001824 46 10 48 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_165682_1_413_+ FIG00001440 23 6 25 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_165684_1_363_+ FIG00001902 31 7 33 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r2_165769_168_413_- FIG00455853 7 4 9 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_165783_261_413_+ FIG00001469 4 2 5 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_165796_156_413_- FIG00075970 6 2 8 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r2_165843_1_413_+ FIG00001062 25 7 27 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_r2_165864_1_412_+ FIG00009682 26 7 27 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_165868_1_412_+ FIG00007137 109 16 110 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_165907_1_412_+ FIG00001168 21 6 24 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_r2_165959_1_248_+ FIG00001819 63 10 63 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_r2_165995_1_412_+ FIG00031731 6 2 7 CRISPR-associated RAMP protein, Csm4 family CRISPR-associated cluster 1 T2D_r2_165999_1_368_- FIG00016110 59 13 60 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_r2_166019_1_232_- FIG00000350 4 3 5 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_166040_1_296_+ FIG00000840 11 4 13 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_r2_166048_1_412_- FIG00000184 17 5 19 Putative deoxyribonuclease YcfH YcfH 3 T2D_r2_166081_1_412_+ FIG01304385 9 4 10 Ribose ABC transport system, periplasmic ribose-binding protein RbsB (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_r2_166127_1_412_+ FIG00066643 56 11 58 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_166161_1_412_+ FIG00000056 72 13 74 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_r2_166199_1_332_- FIG00000465 4 3 6 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_r2_166228_1_412_- FIG00037431 101 14 101 DNA repair protein RadC DNA repair, bacterial 3 T2D_r2_166251_1_412_- FIG00018865 13 4 14 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_166277_1_412_+ FIG00000402 15 4 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_166282_1_412_+ FIG00018561 23 9 27 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_166320_1_372_+ FIG00000822 91 15 91 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_r2_166365_1_401_+ FIG00081580 11 6 12 Arsenic efflux pump protein Arsenic resistance 1 T2D_r2_166384_1_411_- FIG00000877 43 10 45 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_r2_166390_1_411_- FIG00000402 22 7 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_166391_1_411_- FIG00000453 32 7 35 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_r2_166400_1_411_- FIG00000402 10 6 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_166427_1_411_- FIG00001020 8 2 10 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_166437_1_411_+ FIG00000402 11 6 15 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_166440_2_411_- FIG00945384 59 13 61 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_166478_1_411_- FIG01299858 9 2 11 Energy-conserving hydrogenase (ferredoxin), subunit A NiFe hydrogenase maturation 1 T2D_r2_166497_172_411_- FIG01304329 59 9 59 Chromosome (plasmid) partitioning protein ParA Cell Division Subsystem including YidCD 1 T2D_r2_166557_116_411_+ FIG00000520 8 2 10 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_166608_1_411_- FIG00009682 14 6 18 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_166629_1_208_+ FIG00001676 16 3 17 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_166689_1_411_+ FIG00025216 19 6 21 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_166701_1_411_- FIG00028461 18 4 19 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_166724_1_293_- FIG00000933 21 8 22 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_r2_166752_101_411_- FIG00004078 81 12 81 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_166775_1_411_- FIG00020613 98 15 98 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_r2_166804_1_217_- FIG00001583 19 6 20 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_r2_166811_1_411_+ FIG00000088 48 9 49 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_166822_161_411_+ FIG01290653 51 8 51 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_166823_1_411_+ FIG00000990 118 17 118 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_r2_166885_1_410_- FIG00000522 37 10 38 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_166889_1_410_+ FIG00000139 11 4 14 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_166936_1_410_- FIG00000011 113 16 113 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_166938_1_222_+ FIG00015338 8 3 9 D-beta-hydroxybutyrate permease Polyhydroxybutyrate metabolism 5.6 T2D_r2_166939_87_410_+ FIG00001802 19 5 20 FIG001802: Putative alkaline-shock protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_166972_1_410_+ FIG00008941 28 6 29 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_167002_108_410_+ FIG00000075 10 3 11 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_r2_167061_1_410_+ FIG00126843 5 3 7 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r2_167081_1_410_- FIG00000793 30 8 32 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_167105_1_410_- FIG00132617 27 9 29 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_167137_1_410_+ FIG00001548 19 5 22 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_167182_1_410_+ FIG00130344 31 8 33 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_167199_230_410_+ FIG00000025 7 2 9 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r2_167255_1_410_+ FIG00133143 12 4 14 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) Cysteine Biosynthesis 2.17 T2D_r2_167256_1_410_+ FIG00437351 7 3 8 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_r2_167260_1_410_+ FIG00002470 4 2 5 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_167268_1_410_+ FIG01260980 5 3 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_167298_1_410_- FIG00003176 23 7 24 Pyruvate:ferredoxin oxidoreductase, gamma subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_r2_167333_1_409_- FIG00022300 94 14 94 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_167345_1_409_+ FIG00139050 92 15 93 Anaerobic glycerol-3-phosphate dehydrogenase subunit C (EC 1.1.5.3) Respiratory dehydrogenases 1 1.129 T2D_r2_167353_71_409_- FIG00000477 22 4 24 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_r2_167418_95_409_- FIG00106663 27 5 28 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_167431_1_409_+ FIG00000280 70 14 71 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_167481_1_409_- FIG00000089 39 10 40 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_r2_167492_1_409_- FIG00138182 10 3 12 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_r2_167494_1_409_+ FIG00022631 14 6 19 Acetyl-coenzyme A synthetase (EC 6.2.1.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_167507_218_409_+ FIG00000695 15 3 17 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_r2_167531_1_409_- FIG00000165 49 13 50 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r2_167552_1_409_+ FIG00000317 13 4 14 DNA repair protein RecN DNA repair, bacterial 3 T2D_r2_167557_1_409_- FIG00002974 94 16 96 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_r2_167619_1_254_- FIG00016836 30 5 31 Transcription termination protein NusB Transcription factors bacterial 1 T2D_r2_167633_1_409_+ FIG01260980 11 5 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_167647_1_409_+ FIG00064110 44 10 45 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_r2_167679_1_409_+ FIG01260980 13 3 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_167734_1_409_- FIG00077620 5 2 6 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r2_167746_131_409_+ FIG00459778 62 10 62 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_167761_1_191_- FIG00052605 10 3 11 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r2_167773_12_409_- FIG00023004 102 14 103 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r2_167786_18_409_- FIG00067681 6 3 7 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_167838_1_409_+ FIG00022300 22 6 24 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_167876_151_408_- FIG00000645 14 5 21 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_r2_167882_1_202_- FIG00000084 21 4 22 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_r2_167888_1_260_- FIG01304886 62 9 62 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_r2_167894_1_408_+ FIG00000531 69 13 70 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_r2_167915_1_408_- FIG00136922 114 16 114 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_168057_1_408_+ FIG00005924 13 6 18 Excinuclease ABC subunit A paralog in greater Bacteroides group DNA repair, UvrABC system 1 T2D_r2_168068_1_408_- FIG00003506 105 16 105 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_r2_168117_1_408_- FIG00003439 6 2 7 Spore maturation protein A Spore Core Dehydration 1.1 T2D_r2_168142_170_408_+ FIG00000333 17 4 19 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_168169_1_408_- FIG00003712 58 10 61 Fe-S-cluster-containing hydrogenase components 1 Anaerobic respiratory reductases 3 T2D_r2_168237_1_168_- FIG00000208 10 3 11 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_r2_168257_1_345_+ FIG00000111 4 2 6 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_168271_1_408_- FIG00000165 82 13 83 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r2_168374_1_407_- FIG00846773 33 7 34 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r2_168405_1_407_+ FIG00000402 6 4 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_168411_1_407_- FIG01260980 6 4 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_168425_1_146_+ FIG01306622 36 5 36 O-succinylbenzoate synthase (EC 4.2.1.113) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r2_168493_1_194_- FIG00001676 46 6 46 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r2_168519_1_400_+ FIG00000494 24 5 25 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_168543_1_407_- FIG00000866 4 4 6 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r2_168557_85_407_+ FIG00000614 10 3 11 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_r2_168585_1_407_+ FIG00000962 100 14 101 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_168602_1_407_+ FIG01260980 108 16 108 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_168653_1_407_- FIG00000043 15 6 17 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_168659_1_358_+ FIG00000113 17 6 19 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_r2_168692_1_407_+ FIG00001035 121 16 121 Respiratory nitrate reductase beta chain (EC 1.7.99.4) Nitrate and nitrite ammonification 1 T2D_r2_168712_1_407_- FIG00000402 35 7 36 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_168829_1_407_+ FIG00010771 25 8 28 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_168841_1_407_+ FIG00006691 64 11 66 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_168858_1_407_+ FIG00000156 87 14 87 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r2_168885_1_406_+ FIG00026918 78 14 79 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_168944_1_406_+ FIG00011114 36 9 38 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_168946_118_406_- FIG00001530 10 3 12 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_r2_168983_102_406_- FIG00000256 5 3 7 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_r2_169002_1_287_+ FIG00000323 39 7 40 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_r2_169004_115_406_- FIG00048580 6 4 8 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_r2_169048_1_406_- FIG00001548 14 3 15 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_169056_1_392_+ FIG00018699 29 6 35 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_169127_1_406_+ FIG00023369 94 15 94 Chaperone protein DnaK Protein chaperones 2.0 T2D_r2_169143_1_406_- FIG00561498 5 3 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_169190_1_406_+ FIG00001166 107 16 107 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_169198_1_406_+ FIG00002034 6 4 7 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_r2_169238_1_339_+ FIG00000102 25 5 27 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_r2_169253_1_334_+ FIG00074225 14 5 15 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_r2_169275_1_406_- FIG00080955 6 4 8 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_169289_1_406_+ FIG00116638 13 7 15 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_r2_169299_1_406_+ FIG00000402 107 16 107 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_169302_1_406_- FIG00001550 88 14 89 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_r2_169318_1_406_- FIG00085740 10 2 11 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_169319_163_406_- FIG00000911 9 2 11 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r2_169327_1_406_+ FIG00047414 25 8 26 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_r2_169344_1_350_+ FIG01255877 16 7 19 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_r2_169347_1_406_- FIG00001188 19 5 20 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_r2_169352_1_166_- FIG00000372 13 4 14 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r2_169370_1_406_- FIG00016145 12 4 14 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_r2_169397_1_405_+ FIG00028461 71 14 72 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_169414_8_405_- FIG00002431 20 5 22 Succinate dehydrogenase cytochrome b subunit Succinate dehydrogenase 5 T2D_r2_169450_1_405_- FIG00000118 62 11 63 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_r2_169457_1_346_+ FIG00012746 88 13 89 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r2_169466_250_405_- FIG00009229 20 4 21 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_r2_169479_1_405_- FIG00000402 12 2 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r2_169509_1_405_- FIG00000065 105 16 105 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_r2_169511_80_405_- FIG00002214 85 12 85 Xylose activator XylR (AraC family) Xylose utilization 1 T2D_r2_169535_1_363_+ FIG00008941 33 6 34 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_169554_1_378_+ FIG00561498 36 8 37 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_169556_1_405_+ FIG00000011 7 2 8 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_r2_169559_1_405_+ FIG00000146 43 9 44 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_r2_169568_203_405_- FIG00003788 53 8 53 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_169629_1_405_+ FIG00041382 11 5 14 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_r2_169644_1_405_+ FIG00004453 8 3 10 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_r2_169658_1_405_+ FIG00001675 23 8 25 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r2_169665_1_405_+ FIG00066643 19 5 20 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_r2_169672_1_405_- FIG00013638 22 5 24 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_r2_169674_1_200_- FIG00000793 51 7 51 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r2_169693_1_405_+ FIG00054459 81 12 82 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_169743_1_405_+ FIG00016566 101 16 101 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_r2_169765_1_405_+ FIG00034293 4 3 5 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r2_169782_1_281_- FIG00022976 63 11 63 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_169867_1_364_- FIG00022976 94 14 94 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_169868_1_405_- FIG00051439 21 6 22 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_r2_169873_1_316_- FIG00007957 3 3 5 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_169939_1_404_+ FIG00000401 22 7 23 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_r2_169954_1_404_- FIG00003788 80 12 81 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_169981_157_404_+ FIG00016061 48 8 48 L-lactate permease Lactate utilization 3 T2D_r2_169999_1_404_- FIG00001269 26 7 28 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r2_170053_1_404_- FIG00000116 15 5 16 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_r2_170113_1_404_+ FIG00001548 28 6 29 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_170134_1_404_+ FIG00001328 69 11 69 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_r2_170169_1_404_+ FIG00034851 95 15 95 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r2_170208_263_404_- FIG00055715 34 5 34 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_170211_32_404_+ FIG01304886 78 13 78 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_r2_170222_1_404_+ FIG00132617 6 3 8 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_r2_170229_1_404_- FIG00000111 34 9 35 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_170250_1_404_- FIG00000001 99 15 99 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r2_170255_1_404_+ FIG00003394 7 4 9 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_r2_170273_97_404_- FIG00010600 13 4 15 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_r2_170283_1_320_+ FIG00004651 19 4 21 Dipicolinate synthase subunit A (EC 4.2.1.52) Dipicolinate Synthesis 1 T2D_r2_170285_1_404_- FIG00003270 36 10 38 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_r2_170344_43_204_- FIG00000260 35 6 35 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_170369_1_404_+ FIG00031250 113 16 113 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_170371_23_298_+ FIG00001021 55 9 55 Integration host factor beta subunit DNA structural proteins, bacterial 1.1100 T2D_r2_170429_1_403_+ FIG00135025 8 5 10 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_170438_1_228_+ FIG00000141 22 5 23 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_r2_170471_1_138_- FIG00000770 36 5 36 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_r2_170487_1_403_- FIG00020185 22 5 23 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_170489_1_403_+ FIG00561498 9 4 13 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_170501_82_403_+ FIG00000350 18 5 20 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_r2_170527_1_403_- FIG01260980 10 4 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_170539_1_403_+ FIG00022976 31 10 32 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r2_170575_1_403_+ FIG00006691 50 9 52 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_170586_1_403_+ FIG00010661 17 5 18 Alpha-L-Rha alpha-1,2-L-rhamnosyltransferase/alpha-L-Rha alpha-1,3-L- rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_r2_170600_1_403_- FIG00001824 69 14 70 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r2_170616_1_403_- FIG00001388 109 15 109 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_r2_170620_1_403_- FIG00001577 28 6 30 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_r2_170633_1_403_+ FIG00561498 118 16 118 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_r2_170651_126_403_+ FIG00001020 25 6 26 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_r2_170662_1_403_- FIG00000434 12 5 14 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_r2_170672_1_403_+ FIG00000126 78 13 78 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_r2_170680_1_192_+ FIG00000139 21 4 22 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_r2_170716_1_403_+ FIG00000207 95 14 95 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_r2_170725_1_403_- FIG00026918 25 6 26 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_r2_170747_1_403_- FIG00043527 3 3 4 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_r2_170756_1_403_- FIG00001166 63 12 66 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_r2_170767_1_402_+ FIG00018865 34 6 35 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_170815_1_403_+ FIG01956032 19 6 21 Tagatose 1,6-bisphosphate aldolase (EC 4.1.2.40) Lactose and Galactose Uptake and Utilization 1.0 T2D_r2_170817_1_403_- FIG00003715 20 5 22 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r2_170841_1_403_- FIG00000210 22 7 30 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_r2_170862_1_403_- FIG00015519 37 6 38 type 1 fimbriae anchoring protein FimD Type 1 pili (mannose-sensitive fimbriae) 1.x T2D_r2_170916_1_403_- FIG00006997 20 5 21 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_r2_170952_1_265_+ FIG00000962 58 10 58 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_r2_171115_253_402_- FIG00014742 26 4 26 Arginine utilization regulatory protein RocR Arginine and Ornithine Degradation 1.34 T2D_r2_171119_1_290_+ FIG00028461 10 3 11 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r2_171180_1_402_- FIG00003788 13 4 15 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_r2_171193_1_147_- FIG00002974 7 3 8 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_r2_171227_1_402_- FIG00035175 39 9 40 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r2_171258_1_381_+ FIG00001146 40 7 41 GTP cyclohydrolase I (EC 3.5.4.16) type 2 Zinc regulated enzymes 1 T2D_r2_171259_1_333_+ FIG00000377 79 12 79 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_r2_171263_1_402_+ FIG00002049 11 8 14 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_171297_189_402_+ FIG00000370 36 7 37 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_171332_1_331_+ FIG00008507 14 4 16 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_r2_171445_1_401_+ FIG00002470 10 5 12 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_r2_171449_1_401_+ FIG00000080 73 13 73 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_171463_1_401_- FIG00000494 46 9 47 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r2_171490_1_401_+ FIG00055715 108 16 108 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_171508_1_305_- FIG01361711 76 12 76 Hypothetical N-acetyltransferase Cobalt-zinc-cadmium resistance 1.26 T2D_r2_171510_1_341_+ FIG00020897 7 3 9 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_r2_171513_1_401_+ FIG00000464 19 5 21 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r2_171528_129_401_- FIG00000756 13 5 17 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_r2_171529_1_401_- FIG00130344 37 10 38 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r2_171558_1_401_- FIG00018699 8 2 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_171628_1_401_+ FIG00132839 84 15 85 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_171633_1_401_+ FIG00001653 6 3 9 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_r2_171681_1_401_- FIG00132839 39 8 41 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_r2_171787_5_401_+ FIG01260980 12 5 13 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_171797_1_330_+ FIG00008490 36 8 37 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_r2_171808_235_401_+ FIG00044622 43 6 43 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_r2_171820_153_401_- FIG00000084 27 6 28 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_r2_171827_1_401_+ FIG00000114 98 16 98 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_r2_171828_1_254_- FIG00001094 67 10 67 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_r2_171835_1_401_- FIG00050243 7 2 9 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_r2_171842_1_280_+ FIG00001385 56 10 57 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_171865_1_329_- FIG00000211 25 6 26 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_r2_171887_1_401_- FIG00001642 73 13 74 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_r2_171944_1_400_- FIG00041038 6 3 8 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_r2_171980_1_400_+ FIG00000168 28 5 30 Transcription termination protein NusA Transcription factors bacterial 1 T2D_r2_172002_1_400_- FIG00067681 3 2 4 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_172025_1_400_- FIG00008941 105 16 105 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r2_172083_168_400_- FIG00006463 11 5 12 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_172101_270_400_+ FIG00086697 4 2 5 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_r2_172104_1_400_- FIG00000111 53 11 54 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r2_172127_1_400_- FIG00049433 26 7 28 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_r2_172191_1_400_- FIG00025216 6 4 7 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_r2_172212_25_400_- FIG00002011 105 15 105 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_r2_172216_1_400_- FIG00005510 85 15 85 RND efflux system, outer membrane lipoprotein, NodT family Multidrug Resistance Efflux Pumps 1.12 T2D_r2_172246_1_400_- FIG00000088 30 9 31 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_r2_172278_1_400_- FIG00000392 10 5 12 Transcription termination factor Rho Transcription factors bacterial 1 T2D_r2_172299_1_368_+ FIG01292786 3 3 5 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_r2_172338_1_400_+ FIG00003555 6 2 8 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_r2_172368_1_361_- FIG00000552 7 3 9 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_r2_172405_1_400_+ FIG00000080 21 6 22 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r2_172464_1_399_+ FIG00000245 65 11 66 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_172526_1_399_+ FIG00018865 8 4 10 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_172564_1_399_- FIG00004078 67 12 68 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_r2_172583_1_399_+ FIG00019251 89 15 89 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_r2_172630_1_399_- FIG00000085 53 9 54 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_172660_1_399_- FIG00001469 61 12 62 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_r2_172665_1_399_- FIG00000539 24 5 25 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_172736_6_399_- FIG00000717 26 9 27 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_r2_172783_1_399_- FIG00010771 78 13 78 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_r2_172784_1_399_- FIG00000085 39 9 40 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_r2_172804_104_399_+ FIG00018561 64 10 64 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r2_172818_199_399_+ FIG00010844 7 2 9 Flavodoxin Flavodoxin 1 T2D_r2_172825_1_399_+ FIG00030006 92 14 92 ATP-dependent DNA helicase SCO5183 DNA repair, bacterial RecBCD pathway 3 T2D_r2_172835_1_399_- FIG00009682 32 8 33 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_r2_172846_1_399_- FIG00002049 57 10 58 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r2_172882_1_399_+ FIG00000449 68 14 69 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_r2_172898_1_399_- FIG00085740 13 6 15 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r2_172922_1_399_+ FIG00023946 6 2 7 CRISPR-associated protein Cas1 CRISPRs 1 T2D_r2_172950_1_399_- FIG00022976 7 4 9 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r4_38_933_1106_+ FIG00000532 5 2 6 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r4_226_3093_3341_+ FIG00000476 61 8 61 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r4_581_1_183_+ FIG00000023 41 7 41 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_r4_646_1929_2246_- FIG00001067 32 7 33 Rubrerythrin Oxidative stress 1.2 T2D_r4_835_1327_1914_- FIG00000866 16 3 17 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_r4_1113_1_496_- FIG00143364 8 4 11 Minor teichoic acid biosynthesis protein GgaB Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r4_1229_1060_1881_- FIG00001562 15 9 16 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_r4_1783_641_1075_+ FIG00010600 32 6 33 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_r4_2009_1131_1385_+ FIG00002914 8 2 9 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r4_2295_897_1103_- FIG00004843 21 3 22 Protein YidD Cell Division Subsystem including YidCD 1 T2D_r4_2457_951_1100_- FIG00001818 9 2 10 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_r4_2728_806_1081_+ FIG01260980 6 2 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r4_2809_1057_1296_+ FIG00008708 26 7 29 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_r4_3065_563_1006_+ FIG00016566 124 17 124 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_r4_3164_901_1317_- FIG00000210 46 9 47 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_r4_4637_1_998_- FIG00001548 79 16 81 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r4_4770_1_295_+ FIG00033907 4 2 5 Cytochrome c-type biogenesis protein ResA Biogenesis of c-type cytochromes 1.1 T2D_r4_4806_1_480_+ FIG00007157 141 19 141 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_r4_5308_898_1067_- FIG00000188 10 3 11 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_r4_5653_727_1035_+ FIG00000380 12 4 13 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_r4_6110_1_176_- FIG00048268 41 6 41 Membrane protein associated with methylmalonyl-CoA decarboxylase Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r4_7077_1_941_- FIG01260980 90 22 156 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r4_7078_25_699_- FIG00000426 25 5 29 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY Bacterial Chemotaxis 9 T2D_r4_7704_1_301_+ FIG00039528 82 12 82 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) Purine conversions 4.1118100 T2D_r4_8370_244_687_- FIG00077620 78 13 80 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_r4_8435_632_874_- FIG00000811 10 3 11 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_r4_9453_1_126_- FIG00001132 17 4 17 LSU ribosomal protein L16p (L10e) Ribosome LSU bacterial 9 T2D_r4_9791_1_817_- FIG00000370 8 7 10 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r4_9864_1_525_- FIG00000413 56 13 58 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_r4_9952_569_810_+ FIG00000108 57 9 57 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) Streptococcal Hyaluronic Acid Capsule 1 T2D_r4_10021_1_169_- FIG00002389 33 6 33 Oxaloacetate decarboxylase gamma chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_r4_10644_1_782_- FIG00059211 68 14 69 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r4_12724_155_715_- FIG00016566 57 13 60 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_r4_12939_97_297_+ FIG00021289 39 7 39 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r4_13010_508_706_+ FIG00000474 8 3 10 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_r4_13378_1_217_+ FIG00000177 29 5 31 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_r4_14158_380_676_+ FIG00000028 74 11 74 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r4_14395_289_670_+ FIG00000155 21 7 23 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_r4_14533_255_434_- FIG00719736 4 2 5 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r4_14599_244_665_+ FIG00031723 11 3 12 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_r4_14687_1_663_+ FIG01260980 146 26 146 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r4_14752_1_661_- FIG00130344 88 15 89 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_r4_14874_1_398_- FIG00028461 21 4 23 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_r4_14934_347_657_+ FIG00010285 12 6 14 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_r4_15224_1_650_- FIG00028476 16 7 18 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r4_15256_1_650_+ FIG00000717 32 11 35 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_r4_15731_1_267_+ FIG00012067 23 5 26 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_r4_15763_1_397_+ FIG00000001 6 2 8 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r4_15993_90_521_- FIG00000720 25 8 26 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_r4_16031_1_306_- FIG00020613 63 11 64 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_r4_16108_1_299_- FIG00000269 21 3 22 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_r4_16406_1_626_- FIG00004589 21 6 23 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_r4_16583_1_184_+ FIG00000131 44 7 44 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_r4_16590_1_622_- FIG00004763 174 25 174 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r4_16733_1_493_- FIG00058830 140 19 140 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r4_17747_1_145_+ FIG00000782 36 5 36 Exonuclease SbcD DNA repair, bacterial 3 T2D_r4_17799_273_600_+ FIG00000040 20 4 22 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_r4_18033_286_596_+ FIG00001039 81 12 81 Ribonucleotide reduction protein NrdI Ribonucleotide reduction 1 T2D_r4_18447_1_589_- FIG00038343 45 10 46 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_r4_18690_1_272_+ FIG00104852 18 5 20 Predicted D-lactate dehydrogenase, Fe-S protein, FAD/FMN-containing Lactate utilization 3 T2D_r4_18830_1_518_+ FIG00000282 117 19 117 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r4_19043_235_579_- FIG00011380 55 12 57 putative glycosyltransferase - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide Rhamnose containing glycans 4.1 T2D_r4_19195_146_577_- FIG00000159 41 9 43 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_r4_19423_1_574_- FIG00001269 131 21 132 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_r4_19517_356_572_- FIG00000673 26 5 28 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_r4_19611_1_211_- FIG00000001 46 8 46 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_r4_19721_1_570_- FIG00000280 113 20 114 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r4_19945_1_566_+ FIG00000913 138 22 138 Ribonuclease E (EC 3.1.26.12) RNA processing and degradation, bacterial 1 T2D_r4_19969_1_566_+ FIG00034851 49 12 62 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_r4_19994_1_213_+ FIG01260980 37 6 38 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r4_20081_119_564_+ FIG00136036 126 17 126 Betaine reductase component B alpha subunit (EC 1.21.4.4) Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_r4_20344_1_560_+ FIG00006463 16 4 18 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r4_20352_1_539_+ FIG00000329 113 19 114 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_r4_20731_115_555_- FIG00000175 8 2 10 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_r4_20746_352_555_+ FIG00000551 17 4 18 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_r4_21365_1_548_- FIG00132717 10 5 14 ATP-dependent protease La (EC 3.4.21.53) Type II Proteasome bacterial 1 T2D_r4_21461_260_547_+ FIG00945384 19 4 20 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_r4_21505_1_237_- FIG00001636 51 8 52 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_r4_21505_238_546_- FIG00340177 80 11 80 Inorganic pyrophospatase PpaX HPr catabolite repression system 1 T2D_r4_21550_1_546_- FIG00021407 28 11 30 (R)-citramalate synthase (EC 2.3.1.182) Branched-Chain Amino Acid Biosynthesis 8 T2D_r4_21953_1_542_+ FIG00022300 74 15 75 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r4_22070_336_540_+ FIG00451095 36 6 36 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r4_22918_1_532_- FIG00543846 31 7 46 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_r4_23713_1_184_- FIG00475203 13 3 14 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_r4_23745_1_299_+ FIG00000397 74 12 74 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_r4_23831_1_523_- FIG00000476 82 14 82 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_r4_23875_167_523_+ FIG00000025 4 2 5 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_r4_23926_1_277_- FIG00846773 62 9 62 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r4_24045_1_521_+ FIG00000376 42 10 44 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_r4_24128_317_521_+ FIG00000080 33 7 38 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_r4_24275_1_519_- FIG00000156 103 17 105 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_r4_24428_1_518_+ FIG00059211 131 20 131 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_r4_24644_1_516_- FIG00000101 83 15 85 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_r4_25283_1_511_- FIG00093180 136 20 136 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r4_25420_92_304_+ FIG00000092 20 4 20 LSU ribosomal protein L31p Ribosome LSU bacterial 9 T2D_r4_25761_69_266_+ FIG00000259 40 7 40 LSU ribosomal protein L35p Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins) 1 T2D_r4_26768_1_293_+ FIG00005728 7 3 9 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_r4_27141_1_497_+ FIG00054459 61 13 62 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r4_27144_1_497_+ FIG00000594 58 10 59 Chaperone protein HtpG Protein chaperones 2.0 T2D_r4_28299_1_489_- FIG00007328 42 8 44 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_r4_28425_20_488_+ FIG00008941 49 11 53 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_r4_29279_1_337_+ FIG00000522 39 9 40 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r4_29768_1_479_+ FIG00005705 6 2 11 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_r4_29856_1_478_+ FIG00093180 35 7 36 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_r4_29980_1_180_+ FIG00000267 39 6 39 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_r4_30721_1_413_+ FIG00000555 31 7 32 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r4_31053_1_470_+ FIG01260980 13 4 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r4_31136_1_256_- FIG00083946 56 9 56 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r4_31367_1_169_- FIG00459778 43 6 43 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_r4_31473_1_468_+ FIG00451095 120 18 121 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_r4_31794_323_465_+ FIG00030191 14 4 15 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_r4_32094_321_463_+ FIG00009149 4 2 5 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_r4_32329_1_462_+ FIG00000834 126 17 126 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_r4_32455_1_461_- FIG00126843 103 17 104 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r4_32562_1_460_+ FIG00001548 61 11 62 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r4_32804_17_458_- FIG00010844 37 7 38 Flavodoxin Flavodoxin 1 T2D_r4_33029_1_457_- FIG00080955 16 6 18 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r4_33131_1_311_- FIG00138413 76 12 76 Fructose-1,6-bisphosphatase, GlpX type (EC 3.1.3.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r4_33283_1_456_+ FIG00016514 12 4 13 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r4_33315_1_334_- FIG00000352 58 10 59 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_r4_33433_1_455_+ FIG00000288 20 4 22 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_r4_33651_198_453_- FIG00000892 64 9 64 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_r4_33732_1_452_+ FIG00016265 30 9 31 Carboxynorspermidine dehydrogenase, putative (EC 1.1.1.-) Polyamine Metabolism 2 T2D_r4_33909_1_451_- FIG00000317 17 3 19 DNA repair protein RecN DNA repair, bacterial 3 T2D_r4_34717_1_446_+ FIG00229386 37 9 38 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_r4_34781_1_446_- FIG00126843 6 5 7 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r4_34836_1_221_- FIG00001449 52 8 52 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_r4_34896_1_251_- FIG00022976 5 3 6 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_r4_34916_246_445_+ FIG00075970 52 8 52 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_r4_34952_1_445_- FIG00031250 111 17 111 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r4_35029_1_444_+ FIG00048014 121 17 121 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r4_35345_1_304_- FIG00000282 22 7 23 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_r4_35357_1_442_+ FIG00001548 109 17 109 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r4_35408_1_442_+ FIG00034293 75 14 76 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r4_35441_269_442_+ FIG00031250 23 5 24 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r4_35516_1_441_+ FIG00138018 11 4 13 Alpha-glucosidase SusB (EC 3.2.1.20) Cellulosome 1.x T2D_r4_35583_1_273_- FIG00000187 65 9 65 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_r4_36012_48_438_+ FIG00000370 20 6 21 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_r4_36501_1_434_+ FIG00024401 23 5 25 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_r4_36551_1_434_- FIG00001145 40 8 42 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_r4_36580_1_324_+ FIG00030688 52 9 54 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_r4_36689_1_433_+ FIG00719736 19 7 20 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r4_36738_1_433_+ FIG00018369 105 16 105 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_r4_36826_214_432_+ FIG00000317 43 8 43 DNA repair protein RecN DNA repair, bacterial 3 T2D_r4_36847_1_432_+ FIG00000474 107 16 107 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_r4_36868_1_432_- FIG00000157 45 11 47 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_r4_36936_1_431_- FIG00009782 82 15 83 Putative dihydroxyacetone kinase (EC 2.7.1.29), dihydroxyacetone binding subunit Dihydroxyacetone kinases 3 T2D_r4_36987_1_322_- FIG00009395 4 3 6 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_r4_37359_98_428_+ FIG00000455 33 7 35 Malate dehydrogenase (EC 1.1.1.37) Serine-glyoxylate cycle 1 T2D_r4_37519_1_310_- FIG00000402 77 12 77 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_r4_37798_1_425_- FIG00000224 93 15 93 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_r4_38017_1_424_- FIG00001712 95 15 96 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_r4_38057_1_423_- FIG00000111 61 13 62 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_r4_38111_1_238_+ FIG00000793 36 6 38 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r4_38152_1_184_- FIG00023004 34 5 35 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_r4_38398_1_421_+ FIG01260980 50 11 52 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r4_38720_1_419_+ FIG00000504 106 16 106 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_r4_38764_4_418_- FIG00006933 4 2 5 Alpha-1,4-N-acetylgalactosamine transferase PglH (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_r4_38809_1_400_- FIG00000793 33 7 34 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_r4_38949_1_417_+ FIG00002110 43 11 44 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_r4_38958_1_417_+ FIG00000165 106 16 106 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_r4_38971_1_172_- FIG00001364 43 6 43 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Glycine and Serine Utilization 1.12 T2D_r4_39101_1_416_+ FIG00007957 4 6 9 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r4_39112_145_416_- FIG00005529 57 10 57 Nitrate/nitrite transporter Nitrate and nitrite ammonification 1 T2D_r4_39419_1_414_+ FIG00080955 27 9 28 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r4_39667_100_412_- FIG00011115 94 12 94 PTS system, cellobiose-specific IIA component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_r4_39733_1_412_+ FIG00000287 22 5 24 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r4_39969_156_410_- FIG00000532 43 7 44 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r4_40600_1_405_+ FIG00002344 34 8 35 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_r4_40889_196_403_- FIG00126843 50 8 50 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_r4_41056_1_402_- FIG00000317 49 9 50 DNA repair protein RecN DNA repair, bacterial 3 T2D_r4_41231_1_400_- FIG00000038 23 7 24 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_r4_41431_30_399_+ FIG00000028 6 2 8 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_r4_41499_1_399_+ FIG00000134 7 4 8 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_r6_172_881_1042_+ FIG01312219 27 4 27 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_r6_473_523_1098_+ FIG00001548 15 5 16 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r6_532_1098_1258_+ FIG00011106 27 6 27 BatE CBSS-345072.3.peg.1318 1 T2D_r6_547_1078_1250_+ FIG00133325 34 5 34 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_r6_572_938_1227_- FIG00000721 24 4 25 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_r6_603_939_1204_- FIG00006764 52 8 52 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_r6_1013_1_516_- FIG00000532 65 14 66 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_r6_3501_1_128_+ FIG00022300 29 4 29 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_r6_3957_1_604_- FIG01260980 76 13 77 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r6_4216_420_588_- FIG00000494 21 4 22 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r6_4624_243_563_+ FIG00000198 23 6 24 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_r6_5107_364_546_- FIG00000184 5 2 7 Putative deoxyribonuclease YcfH YcfH 3 T2D_r6_5162_1_544_- FIG00000372 17 7 20 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_r6_5562_398_531_- FIG01954097 18 4 19 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r6_6731_1_134_- FIG00133325 27 4 27 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_r6_6826_1_206_- FIG00034293 3 3 4 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_r6_7573_256_486_- FIG00014556 5 2 6 DNA sulfur modification protein DndD DNA phosphorothioation 1 T2D_r6_7645_1_202_+ FIG00000168 45 7 45 Transcription termination protein NusA Transcription factors bacterial 1 T2D_r6_8733_323_466_- FIG00000187 5 2 6 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_r6_9003_1_461_+ FIG00047056 59 10 60 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_r6_9706_1_449_+ FIG00000494 8 2 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_r6_10848_1_303_- FIG00000555 38 7 39 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_r8_131_673_1091_+ FIG00003270 74 11 75 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_r8_481_268_746_+ FIG01260980 57 13 58 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r8_1967_292_493_- FIG00000720 50 8 50 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_r8_2899_1_454_+ FIG00140555 4 3 6 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_r8_3753_1_413_+ FIG00001548 29 9 30 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_r8_3807_1_207_+ FIG00001882 9 4 13 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_r10_991_1_175_+ FIG00001577 40 6 40 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_3_5713_5865_- FIG00134135 11 3 12 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_3_44580_44867_- FIG00000038 12 5 13 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_3_60635_60808_- FIG00064110 7 2 8 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_3_71565_71801_- FIG00000464 8 4 9 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_3_79443_79829_- FIG00000017 48 10 49 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_3_145164_145484_- FIG00047414 11 3 13 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_3_147509_147673_- FIG00000277 7 4 8 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_4_90496_90720_+ FIG00004021 4 2 5 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_4_113384_113710_- FIG00008507 4 2 6 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_8_46885_47022_- FIG00010844 11 3 12 Flavodoxin Flavodoxin 1 T2D_unique_8_68855_69013_- FIG00019415 8 2 9 Putative activity regulator of membrane protease YbbK CBSS-316057.3.peg.659 1 T2D_unique_8_125728_126015_- FIG00004037 10 4 12 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_11_61796_62218_- FIG00023943 24 7 26 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_11_90727_91608_- FIG00000101 80 18 83 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_11_117611_117955_- FIG00000967 11 5 13 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_unique_13_16084_16542_- FIG00000206 79 14 81 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_13_121836_122771_+ FIG00000165 177 33 179 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_15_24794_25528_- FIG00000594 58 11 61 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_15_37175_37486_- FIG00000276 35 8 36 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_unique_17_91771_92124_- FIG00043259 7 4 9 Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_19_9890_10027_+ FIG00000126 14 3 15 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_19_53618_53911_+ FIG00004229 5 2 6 Heptaprenyl diphosphate synthase component I (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_19_84829_85122_- FIG00000032 9 4 10 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_23_27372_27992_+ FIG00004104 156 22 156 Putative succinate dehydrogenase cytochrome b subunit Succinate dehydrogenase 5 T2D_unique_23_27995_28237_+ FIG00004104 37 8 38 Putative succinate dehydrogenase cytochrome b subunit Succinate dehydrogenase 5 T2D_unique_23_58966_60150_+ FIG00136922 250 36 253 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_23_62176_62985_+ FIG00001020 158 24 160 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_28_81823_82233_- FIG00077620 72 12 73 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_33_41852_42331_- FIG00001469 27 7 29 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_37_63120_63620_+ FIG00004764 31 8 32 Ammonium transporter Ammonia assimilation 1 T2D_unique_38_995_1333_- FIG00116638 10 4 12 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_39_2583_3023_+ FIG00083946 21 8 22 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_39_37616_37954_+ FIG00002449 4 2 6 Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48) Exopolysaccharide Biosynthesis 1.0 T2D_unique_39_39689_39985_+ FIG00035701 3 2 4 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_39_63615_63962_+ FIG00000157 29 5 30 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_40_36438_36965_+ FIG00008907 7 3 10 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_42_30962_31192_+ FIG00002328 18 5 19 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_42_57844_58119_- FIG00000388 14 4 17 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_46_55851_56054_- FIG00092649 12 2 13 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_46_61033_61914_+ FIG00028203 79 20 80 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_47_30247_30978_+ FIG00002344 41 13 42 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_50_16837_17055_+ FIG00007694 25 5 26 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_51_27643_27879_- FIG00018369 17 3 18 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_55_32898_33131_- FIG00002344 13 3 14 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_55_58453_58737_- FIG00000258 41 7 42 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_56_12033_12419_+ FIG00000303 49 9 50 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_64_7866_8054_+ FIG00002914 14 2 15 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_66_14766_14981_+ FIG00000043 20 5 21 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_68_17156_17773_- FIG00000085 35 8 38 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_68_21888_22325_- FIG00003955 19 6 21 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_71_44052_44969_+ FIG00030688 141 23 143 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_79_28847_29089_- FIG00007694 24 4 25 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_79_50831_51442_- FIG00001642 8 2 9 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_80_48465_48836_+ FIG00000141 45 9 46 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_83_25369_25722_- FIG00042781 11 4 13 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_86_7052_7237_+ FIG00001819 9 3 10 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_91_13544_13813_- FIG00040817 27 5 28 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_95_29102_29992_+ FIG00000317 32 8 35 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_101_27738_28931_- FIG00026918 13 6 17 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_101_31183_31854_- FIG00000208 29 12 33 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_101_41471_41938_- FIG00012067 17 6 18 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_103_27958_28308_+ FIG00006764 15 6 17 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_103_38753_38953_+ FIG00000382 19 3 21 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_106_33842_34216_- FIG00000001 4 3 7 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_111_2520_2948_- FIG00000211 98 16 99 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_111_21877_22209_- FIG00000154 17 7 18 LSU ribosomal protein L17p Ribosome LSU bacterial 9 T2D_unique_111_22303_22839_- FIG00000140 91 15 92 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_111_29518_29769_- FIG00000200 25 8 26 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_unique_116_3777_3956_- FIG00002920 15 4 16 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_116_9806_9958_- FIG00229257 23 4 24 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_116_25623_25982_+ FIG00018561 80 13 81 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_120_2224_2535_+ FIG00001675 15 5 16 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_122_15031_16149_+ FIG00001022 211 34 212 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_122_24374_25057_+ FIG00031250 27 6 29 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_122_29689_30009_+ FIG00000456 4 2 6 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_122_40880_41365_+ FIG00001203 40 9 42 Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_126_2902_3237_- FIG00146582 34 7 35 Putative glycogen debranching enzyme, archaeal type, TIGR01561 Glycogen metabolism 3 T2D_unique_126_44958_45257_+ FIG00000476 25 5 26 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_130_21940_22380_- FIG00002252 17 5 19 Galactose/methyl galactoside ABC transport system, D-galactose-binding periplasmic protein MglB (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_130_28864_29196_- FIG00002251 14 4 16 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_134_17865_18002_+ FIG00000329 12 3 13 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_136_9909_10520_- FIG00000840 68 12 70 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_136_13982_14200_- FIG00000193 28 6 29 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_unique_136_23870_24079_- FIG00002328 14 4 15 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_136_27924_28079_- FIG00067248 13 3 14 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_138_28837_29040_- FIG00000290 4 2 5 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_138_29910_30095_- FIG00000267 6 2 7 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_144_26697_27014_+ FIG00000043 23 6 24 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_146_3631_3822_- FIG00034392 8 2 9 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_149_18637_18963_+ FIG00000101 28 6 29 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_149_30878_31723_- FIG00031723 3 3 7 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_unique_152_4610_4987_- FIG00000521 5 2 6 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_unique_152_10897_11223_- FIG00092649 11 4 12 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_157_29006_29515_+ FIG00028461 30 7 32 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_169_26569_26769_- FIG00018396 23 5 23 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_180_29704_29886_- FIG00010508 6 3 7 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_186_4581_5036_+ FIG00002354 27 8 28 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_188_4019_4477_+ FIG00134060 27 8 28 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_188_17016_17363_+ FIG00135554 13 3 15 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_209_10968_11303_- FIG00561498 7 3 8 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_209_34972_35523_+ FIG00075702 80 16 82 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_214_12126_12464_+ FIG00003472 26 6 27 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_220_6875_7936_- FIG00018369 133 25 134 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_220_15494_15799_- FIG00048580 6 3 7 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_226_32228_33010_+ FIG00000176 95 19 96 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_234_11524_11862_+ FIG00000219 40 9 41 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_234_15474_16187_+ FIG00001577 35 13 37 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_240_16846_17004_+ FIG00028461 8 2 9 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_248_17689_17901_- FIG00016145 22 5 24 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_unique_260_3073_3996_+ FIG01304601 128 26 130 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_260_4059_5225_+ FIG01304601 120 25 122 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_263_16464_17075_+ FIG00000001 34 9 35 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_268_4272_4976_- FIG00018396 130 22 131 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_268_9390_9917_- FIG00000308 123 20 124 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_268_14872_15258_- FIG00000043 67 10 68 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_269_2496_2768_- FIG00002412 3 3 6 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_unique_285_15902_16765_- FIG00092725 186 30 187 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Anaerobic respiratory reductases 3 T2D_unique_294_13663_14010_+ FIG00007586 4 3 5 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_295_18845_19009_+ FIG00000621 3 2 4 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_299_28094_28333_+ FIG00000594 8 3 9 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_301_980_1210_- FIG00000198 32 6 33 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_307_18544_18861_- FIG00000538 71 12 72 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_unique_316_8824_8991_+ FIG00000323 6 3 7 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_317_6116_6868_+ FIG00000279 8 6 11 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_331_9254_9946_- FIG00058830 113 22 115 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_357_17941_18162_- FIG00006151 7 4 8 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_397_3958_4395_- FIG00003715 3 2 5 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_399_7304_8008_+ FIG00719736 16 8 18 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_399_10822_11247_- FIG00031250 8 3 9 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_401_6861_7349_- FIG00003596 20 6 21 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_415_18868_19293_- FIG00046929 27 5 28 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_417_17768_17908_- FIG00000323 25 5 26 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_418_3541_3861_- FIG00000242 30 7 31 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_418_14533_15126_+ FIG00000624 56 9 57 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_418_17498_18208_- FIG00003439 6 3 8 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_420_17665_17997_+ FIG00135554 32 9 33 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_443_19147_20205_+ FIG00007957 212 31 214 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_462_9746_9988_+ FIG00229199 52 8 52 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_469_3466_3852_- FIG00000298 8 4 11 GTP-binding protein EngB Universal GTPases 2 T2D_unique_472_20877_21770_- FIG00002034 5 2 7 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_474_12802_13086_+ FIG00046929 25 5 26 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_477_14806_14982_+ FIG00000277 31 6 31 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_477_18562_19101_+ FIG00003484 26 7 28 Lactaldehyde reductase (EC 1.1.1.77) L-rhamnose utilization 1 T2D_unique_489_4621_5040_+ FIG00000636 38 7 40 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_489_17162_17923_- FIG00001469 17 7 18 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_490_7931_8095_- FIG00067300 14 2 15 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_493_2092_2331_+ FIG00000256 28 6 29 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_500_12418_12942_- FIG00001562 9 4 14 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_unique_504_15888_16109_- FIG00004209 35 5 36 Lipopolysaccharide core biosynthesis protein WaaP (EC 2.7.-.-), heptosyl-I-kinase LOS core oligosaccharide biosynthesis 1.x T2D_unique_508_19939_20238_- FIG00000207 15 5 17 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_511_7363_8085_+ FIG00000449 153 24 155 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_511_16775_16987_+ FIG00000221 40 6 41 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_516_1_575_+ FIG00003955 46 9 48 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_518_15218_15436_+ FIG00005860 13 4 15 SusD, outer membrane protein Cellulosome 1.x T2D_unique_519_9099_9560_+ FIG00000388 115 17 116 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_521_9963_10583_- FIG00022300 81 17 82 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_530_14870_15010_+ FIG00000261 14 3 15 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_560_2751_3008_+ FIG00052300 45 8 45 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_562_14650_14898_- FIG00000013 3 4 7 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_563_10805_11521_- FIG00005860 56 11 58 SusD, outer membrane protein Cellulosome 1.x T2D_unique_568_9973_10392_- FIG00000188 12 5 13 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_584_940_1245_- FIG00000412 18 4 19 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_587_15939_16481_- FIG00001407 58 11 60 FKBP-type peptidyl-prolyl cis-trans isomerase fklB (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_590_13220_13393_- FIG00008080 7 3 10 YafQ toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_591_807_1973_- FIG00130339 202 32 204 Cytochrome c heme lyase subunit CcmF Copper homeostasis 12 T2D_unique_591_14627_15103_+ FIG00957042 67 13 68 Fe2+/Zn2+ uptake regulation proteins Oxidative stress 1.2 T2D_unique_591_19915_20273_- FIG00006551 57 10 58 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_605_3060_3353_+ FIG00001636 3 4 5 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_unique_623_8012_8206_+ FIG00000897 17 4 18 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_634_970_1389_- FIG00059426 14 4 15 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_634_6809_7207_- FIG00000601 29 6 30 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_641_18763_19056_+ FIG00000834 42 8 43 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_653_11756_12109_+ FIG00042781 25 6 26 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_663_9528_9812_- FIG00001604 25 7 26 Ornithine decarboxylase (EC 4.1.1.17) Polyamine Metabolism 2 T2D_unique_674_11916_12233_- FIG00014907 3 2 5 Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_681_12929_13324_- FIG00058830 54 11 56 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_685_12938_13507_- FIG00016265 19 5 21 Carboxynorspermidine dehydrogenase, putative (EC 1.1.1.-) Polyamine Metabolism 2 T2D_unique_685_13590_13892_- FIG00052802 22 6 23 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_unique_696_3987_4208_- FIG00014990 35 6 36 Similar to ribosomal large subunit pseudouridine synthase D, Bacillus subtilis YjbO type CBSS-222523.1.peg.1311 1 T2D_unique_707_14807_15589_- FIG00012547 6 4 11 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) Biotin biosynthesis 1X T2D_unique_723_9120_9581_+ FIG00000176 55 10 56 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_736_13692_13967_+ FIG00003307 11 4 13 FIG003307: hypothetical protein CBSS-323097.3.peg.2594 1 T2D_unique_736_14603_14812_+ FIG00000394 48 8 48 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_737_12090_12941_+ FIG01239241 4 4 8 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_742_4977_5750_- FIG00079740 20 8 23 Xyloside transporter XynT Xylose utilization 1 T2D_unique_745_3739_4152_+ FIG00023946 31 6 32 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_776_15035_16009_+ FIG00000147 94 22 95 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_789_306_620_- FIG00001862 37 7 38 L-rhamnose mutarotase L-rhamnose utilization 1 T2D_unique_835_6129_6647_+ FIG00000102 82 16 83 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_850_8892_9182_- FIG00020306 14 4 15 ABC-type hemin transport system, ATPase component Hemin transport system 1 T2D_unique_856_688_993_+ FIG00137739 30 5 31 Positive regulator of Tartrate dehydrogenase/decarboxylase/D-malic enzyme Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_859_7083_7259_+ FIG00000102 34 6 34 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_869_7882_8139_- FIG00139058 23 4 24 Putrescine/proton symporter, putrescine/ornithine antiporter PotE Polyamine Metabolism 2 T2D_unique_882_2986_3879_- FIG00000624 233 34 233 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_889_11495_12166_+ FIG01367215 114 18 118 predicted xylose isomerase Xylose utilization 1 T2D_unique_889_12220_13914_+ FIG01367215 155 26 157 predicted xylose isomerase Xylose utilization 1 T2D_unique_909_15209_15648_+ FIG00000113 44 12 45 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_929_3716_4006_+ FIG00000157 71 11 71 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_929_4063_5349_+ FIG00000157 259 37 261 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_934_1030_1593_+ FIG00000187 82 14 83 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_936_7301_7861_- FIG00229199 123 20 124 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_950_3923_4168_- FIG00108342 42 6 43 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_950_4895_5902_- FIG00001188 222 35 223 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_951_183_569_+ FIG00000720 70 13 71 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_951_4229_4648_+ FIG00000414 68 13 70 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_955_6793_7002_+ FIG00134060 24 6 26 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_968_8824_8991_+ FIG00007957 8 2 9 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_989_4788_4991_+ FIG00000578 23 5 24 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_1034_13203_13697_+ FIG00130344 71 12 73 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_1045_1_376_- FIG00000624 96 14 96 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_1045_410_916_- FIG00000076 103 18 104 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_1045_5537_5926_- FIG00229257 44 10 45 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_1056_9792_10034_+ FIG00000317 45 7 45 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_1057_5065_5490_+ FIG00000397 25 8 27 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_1076_4660_4962_- FIG00000126 30 7 31 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_1076_13720_13946_- FIG00405688 35 5 36 Teichuronic acid biosynthesis protein TuaE, putative secreted polysaccharide polymerase Teichuronic acid biosynthesis 9 T2D_unique_1078_13564_13932_+ FIG00000408 87 13 87 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_1083_1_329_+ FIG00000824 18 6 19 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_1086_1_195_- FIG00001635 20 6 21 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_1098_9200_9808_+ FIG00000477 151 23 152 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_1119_6954_7163_- FIG00079822 33 6 34 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_1122_11221_11994_+ FIG00000401 64 15 65 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_1202_7208_8017_+ FIG00076542 37 10 40 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_1202_8029_8331_+ FIG00076542 6 4 8 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_1204_11279_12166_+ FIG00003086 23 7 25 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_1213_6070_7002_+ FIG00041038 96 23 99 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_1225_3968_4279_- FIG00000367 3 2 4 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_1230_1960_2106_- FIG00112098 21 3 22 Putative phosphatase YieH 2-phosphoglycolate salvage 1 T2D_unique_1234_4634_5059_+ FIG00018457 9 3 10 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_1238_7942_8448_- FIG00000113 111 18 111 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_1238_11209_11598_- FIG00001269 97 14 98 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_1247_6210_7001_+ FIG00000395 168 26 169 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_1264_2096_2671_+ FIG00055134 92 16 93 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily M (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_1276_6726_6992_+ FIG01288915 11 3 12 N-Ribosylnicotinamide phosphorylase (EC 2.4.2.1) NAD and NADP cofactor biosynthesis global E T2D_unique_1276_9581_10003_+ FIG00000387 107 15 108 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_1291_8415_8645_- FIG00005628 22 6 23 KH domain RNA binding protein YlqC KH domain RNA binding protein YlqC 1.11 T2D_unique_1300_9087_9665_+ FIG00001505 53 13 55 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_1304_720_1094_+ FIG00044622 70 10 71 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_1304_8415_9086_+ FIG00055715 135 21 136 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_1306_9809_10357_- FIG00000458 72 12 72 Glycyl-tRNA synthetase alpha chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_1322_3926_4282_- FIG00000032 3 2 5 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_1322_6930_7172_- FIG00000117 10 2 11 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_1329_12173_12364_+ FIG00000877 14 4 15 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_1332_6655_6849_+ FIG00084255 5 2 7 Stage III sporulation protein AC Sporulation Cluster III A 1.x T2D_unique_1359_10976_11908_- FIG00021289 208 35 208 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_1359_11926_12177_- FIG00021289 53 7 54 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_1364_3978_4256_- FIG00066643 11 4 13 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_1371_6989_7714_+ FIG00030688 4 3 5 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_1371_7716_8024_+ FIG00074225 17 4 18 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_1371_11350_11994_+ FIG00000101 79 16 80 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_1387_11826_12019_- FIG00004169 6 3 8 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_1416_1823_2002_+ FIG00085740 9 3 10 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_1449_1864_2007_+ FIG00000899 15 3 16 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_1462_11005_11385_+ FIG00016566 35 8 36 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_1468_4326_5240_+ FIG00060517 134 22 136 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_1472_3575_3910_- FIG00001712 13 7 16 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_1478_10_528_- FIG00000241 76 11 78 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_1490_10055_11014_+ FIG00028203 91 22 93 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_1490_11041_11193_+ FIG00028203 6 2 7 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_1499_2722_3084_+ FIG00037431 26 7 27 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_1515_1_630_- FIG00000102 108 21 109 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_1515_6978_7541_- FIG00000056 101 18 102 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_1538_6324_7106_+ FIG00020613 65 16 69 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_1541_8506_9015_+ FIG00005237 13 5 15 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_1550_3152_3640_+ FIG00003997 132 19 132 Protein with similarity to RtcB Translation termination factors bacterial 1.13 T2D_unique_1558_6051_6299_+ FIG00014849 10 2 11 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_1567_1_1003_+ FIG01260980 104 25 106 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_1570_1804_2310_- FIG00000131 72 12 75 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_1574_3889_4350_- FIG00000391 44 9 46 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_1599_9698_10123_+ FIG01297554 39 8 43 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_1601_3664_3888_- FIG00058830 53 9 53 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_1621_6104_6607_- FIG00000355 36 7 39 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_1621_7551_7889_- FIG00132617 4 3 6 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_1623_4166_5122_+ FIG00000494 22 8 24 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_1633_4324_4863_- FIG00001067 58 13 59 Rubrerythrin Oxidative stress 1.2 T2D_unique_1645_7718_7954_- FIG00001054 9 2 10 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_1646_8905_9306_- FIG00132586 11 6 12 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_1675_6130_6783_+ FIG00000047 92 20 93 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_1677_9299_9670_- FIG00229257 8 2 9 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_1686_10351_10574_+ FIG00019212 5 3 7 Cobalt-precorrin-6x reductase (EC 1.3.1.54) Cobalamin synthesis 2 T2D_unique_1690_525_971_- FIG00000510 105 16 106 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_1690_1441_2328_+ FIG00561498 144 21 146 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_1690_2903_3043_+ FIG00146516 22 3 23 Similar to Hydroxyacylglutathione hydrolase, but in an organism lacking glutathione biosynthesis Glutathione: Non-redox reactions 9 T2D_unique_1690_3557_4075_+ FIG00000911 109 16 110 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_1693_7049_7996_+ FIG00018369 80 18 83 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_1712_6591_7034_+ FIG00001011 4 2 6 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_1741_1154_2017_+ FIG00034293 146 25 148 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_1746_4412_4927_- FIG00006092 3 2 5 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_1767_1_404_+ FIG01280345 15 7 16 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_1770_3117_4169_+ FIG00134135 83 17 84 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_1773_847_1035_+ FIG00711303 14 3 16 Guanine-hypoxanthine permease Purine Utilization 1 T2D_unique_1775_8240_8872_- FIG00076542 30 6 32 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_1776_8919_9182_- FIG01304329 3 2 4 Chromosome (plasmid) partitioning protein ParA Cell Division Subsystem including YidCD 1 T2D_unique_1795_1_727_+ FIG00037943 4 2 6 Transcription antitermination protein UpdY Transcription factors bacterial 1 T2D_unique_1800_1_165_- FIG00004220 8 3 10 Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5) Protein degradation 1 T2D_unique_1800_8075_8335_+ FIG00000412 21 5 22 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_1803_2952_3263_- FIG00134342 23 5 24 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_1816_7868_8932_- FIG00132617 149 30 152 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_1821_5060_5260_+ FIG00016888 8 3 9 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_1840_7610_7972_- FIG00004743 48 10 50 Lactoylglutathione lyase (EC 4.4.1.5) Methylglyoxal Metabolism 3.x T2D_unique_1870_5645_6184_+ FIG00000080 5 2 8 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_1884_1895_2401_- FIG00000221 17 6 19 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_1933_1959_2876_- FIG00000372 19 7 21 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_1953_943_1350_- FIG00000128 25 6 27 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_1961_1132_1665_- FIG00001105 10 6 12 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_unique_1983_1_295_+ FIG00011114 35 8 37 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_2047_6484_7005_+ FIG00138298 41 11 42 Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF L-rhamnose utilization 1 T2D_unique_2075_4987_5865_- FIG00000056 144 28 145 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_2075_8087_8257_+ FIG00001676 16 5 18 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_2076_2174_2998_- FIG00846773 216 32 217 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_2103_7842_8066_+ FIG00003955 6 2 8 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_2105_1_404_+ FIG00018865 32 8 33 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_2105_477_1016_+ FIG00451095 21 6 23 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_2105_7013_7438_+ FIG00000182 86 15 87 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_2119_1156_1464_+ FIG00001311 10 4 12 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_unique_2119_4224_4607_+ FIG00003212 21 5 22 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_2123_4773_5036_+ FIG00628860 50 8 51 Hypothetical protein Cj1505c Selenocysteine metabolism 1.1 T2D_unique_2152_4558_5007_+ FIG00000202 40 10 41 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_2152_7626_7940_+ FIG00002803 8 6 9 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_2155_343_957_- FIG00018865 37 10 39 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_2155_1299_1910_- FIG00002049 20 8 22 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_2155_1991_2317_- FIG00002049 7 3 10 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_2166_1835_2299_- FIG00085033 7 2 8 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_2183_3574_3762_- FIG00000645 9 2 10 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_2189_2801_3022_+ FIG00088067 5 2 7 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_2207_7949_8677_- FIG00047056 82 18 84 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_2216_4408_5085_+ FIG00000038 51 12 52 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_2235_492_1022_+ FIG00003715 123 17 124 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_2242_2990_3319_- FIG00092649 6 3 8 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_2267_2933_3142_- FIG00000897 18 4 19 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_2275_6967_7443_- FIG00000207 8 3 9 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_2286_3297_3995_+ FIG00018369 69 16 71 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_2342_1782_1922_- FIG00000036 11 4 12 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_2342_5622_5963_- FIG00000200 26 6 27 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_unique_2344_1_191_- FIG00007328 8 2 9 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_2348_1887_2168_+ FIG00001980 16 3 17 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_2365_1936_2487_- FIG00034652 19 4 21 Beta-galactosidase small subunit (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_2365_4772_5491_- FIG00003810 22 5 23 Arginase (EC 3.5.3.1) Arginine and Ornithine Degradation 1.34 T2D_unique_2373_5948_6484_- FIG00004310 102 17 103 Tellurite resistance protein TehA Tellurite resistance: Chromosomal determinants 1.1 T2D_unique_2392_2424_2960_- FIG00000487 40 12 42 ATP-dependent protease HslV (EC 3.4.25.-) Proteasome bacterial 1 T2D_unique_2404_7620_7991_+ FIG00000194 24 5 27 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_2498_7680_7889_+ FIG00009680 38 8 38 LysR family transcriptional regulator YbhD DNA-binding regulatory proteins, strays 1 T2D_unique_2520_1_445_+ FIG00000194 91 15 92 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_2551_1170_1649_- FIG01280345 33 7 35 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_2551_7580_7897_+ FIG01318274 8 4 13 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_2563_2387_2995_- FIG00001824 62 14 63 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_2592_1049_1444_+ FIG00000015 14 5 16 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_2605_3519_3818_- FIG01260980 14 5 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_2613_5142_5987_- FIG00000899 209 32 209 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_2616_7173_7709_+ FIG00067681 10 5 11 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_2631_2633_2905_- FIG00000367 8 3 9 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_2672_2450_3019_+ FIG00001067 87 15 88 Rubrerythrin Oxidative stress 1.2 T2D_unique_2676_6960_7579_- FIG00000139 15 6 17 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_2689_1661_1969_+ FIG01318274 5 3 7 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_2728_4908_5378_- FIG00000282 51 11 53 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_2728_5857_6642_- FIG00000280 89 18 91 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_2754_4966_5946_- FIG00059211 5 5 19 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_2769_1_797_- FIG00020613 102 24 104 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_2803_7178_7396_- FIG00004078 43 8 44 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_2809_7055_7375_+ FIG00000032 25 6 30 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_2826_5554_5967_- FIG00030688 70 13 72 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_2830_3780_4088_+ FIG00009210 7 2 8 FIG009210: peptidase, M16 family CBSS-257314.1.peg.676 4.x T2D_unique_2852_80_610_+ FIG00000256 94 19 95 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_2852_2775_3047_+ FIG00000065 59 9 60 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_2852_7069_7279_+ FIG00000560 20 3 21 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_2921_6182_6718_- FIG00103661 34 8 36 Transcriptional regulator, MerR family, near polyamine transporter Polyamine Metabolism 2 T2D_unique_2925_6216_7010_+ FIG00018369 49 14 52 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_2928_984_1229_- FIG00000290 11 3 12 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_2928_6244_6948_+ FIG00006092 33 11 35 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_2970_6887_7105_- FIG00003472 13 4 14 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_2985_1987_2235_- FIG00000770 20 5 21 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_3008_5119_5613_+ FIG00023946 30 8 31 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_3026_8_622_- FIG00000532 130 20 131 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_3045_2795_3034_+ FIG00006764 28 6 30 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_3055_6343_6959_+ FIG00000391 148 22 149 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_3068_1415_1804_- FIG00000101 42 8 44 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_3077_6139_6921_- FIG00004655 47 9 48 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_3114_1977_2273_- FIG00001802 3 2 5 FIG001802: Putative alkaline-shock protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_3129_3665_3874_- FIG00008294 5 2 6 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_3133_6449_6664_+ FIG00000394 3 2 4 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_3149_6191_6812_+ FIG00142848 149 24 149 Shikimate 5-dehydrogenase I gamma (EC 1.1.1.25) Chorismate Synthesis 1 T2D_unique_3229_1105_1602_+ FIG00000117 58 10 61 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_3233_2948_3880_- FIG00022300 17 6 21 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_3236_4717_5076_+ FIG00000028 56 10 57 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_3270_1_372_- FIG00010508 9 5 11 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_3272_1_315_- FIG00005860 25 6 26 SusD, outer membrane protein Cellulosome 1.x T2D_unique_3280_4078_4917_+ FIG00002344 29 10 30 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_3341_2077_2331_+ FIG00001133 3 4 5 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_unique_3342_5468_6070_+ FIG00000065 88 17 90 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_3351_4904_5050_+ FIG00076542 17 3 18 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_3373_26_979_- FIG00000176 108 22 110 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_3373_1966_2967_- FIG00042267 15 7 17 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_3424_787_1098_+ FIG00002332 4 3 5 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_unique_3436_717_959_- FIG01031896 7 3 8 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_3460_2775_2912_- FIG00000086 4 3 5 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_3477_2955_3182_- FIG00001470 8 3 10 Signal recognition particle associated protein Two cell division clusters relating to chromosome partitioning 1 T2D_unique_3509_1234_1833_- FIG00018457 29 7 32 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_3509_1950_2723_- FIG00018457 33 10 35 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_3518_1_445_- FIG00037273 60 10 61 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_unique_3557_434_1129_+ FIG00001106 35 11 36 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_3569_4909_5916_- FIG00000358 212 34 213 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_3598_4875_5021_+ FIG00002492 24 4 24 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (EC 6.3.2.-) Peptidoglycan biosynthesis--gjo 1 T2D_unique_3658_1_383_- FIG00001635 8 6 24 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_3699_513_950_- FIG00002049 20 7 22 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_3699_5943_6098_- FIG00001732 7 2 8 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_3737_1898_2503_- FIG00000388 22 7 24 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_3767_1_570_+ FIG00004172 51 10 53 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_unique_3785_2093_2761_- FIG00000206 31 9 33 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_3790_2549_3073_+ FIG00000521 3 2 6 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_unique_3827_3933_4118_- FIG00007957 7 2 8 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_3834_1870_2025_+ FIG00000206 12 3 13 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_3910_691_942_- FIG00008490 15 5 17 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_3910_996_1550_- FIG00008490 79 13 80 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_3930_996_1979_- FIG00002020 159 27 161 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_3954_1689_2084_+ FIG00001980 23 4 24 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_3963_1_713_- FIG00007514 77 15 78 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_3966_4168_4794_+ FIG00031250 125 20 126 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_3977_5275_5816_+ FIG01304530 7 4 14 Phage terminase, large subunit Phage head and packaging 1 T2D_unique_3980_5206_5616_+ FIG00000777 14 4 15 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_4002_3737_4075_+ FIG00598409 18 3 20 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_4014_2675_2911_- FIG00011382 3 3 6 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_unique_4047_4129_5750_+ FIG00000636 151 30 174 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_4054_4511_4831_- FIG00002299 17 4 18 Ascorbate-specific PTS system, EIIB component (EC 2.7.1.69) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_4091_3036_3239_+ FIG00001497 3 2 4 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Cell division-ribosomal stress proteins cluster 1 T2D_unique_4110_1_820_- FIG00085033 17 7 19 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_4145_4002_4736_+ FIG00058830 27 8 29 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_4168_2302_2997_+ FIG00011659 6 4 12 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_4168_5082_5632_+ FIG00049433 6 4 10 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_4186_1_166_- FIG00000202 16 3 17 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_4207_3444_3983_- FIG00000402 24 8 25 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_4207_3989_4786_- FIG00000402 33 8 35 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_4260_3063_3572_+ FIG00026595 109 18 109 ABC transporter membrane-spanning permease, Pep export, Vex3 Streptococcus pneumoniae Vancomycin Tolerance Locus 3 T2D_unique_4274_1_316_+ FIG00016514 4 2 5 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_4277_5244_5528_- FIG00000141 18 6 20 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_4278_1_357_+ FIG00229386 18 5 19 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_4306_4488_5012_+ FIG00005237 10 3 12 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_4314_4719_5075_+ FIG00000325 26 7 27 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_4390_4545_5015_+ FIG00031250 36 9 38 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_4427_4920_5401_- FIG00041038 17 5 19 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_4499_2979_3917_- FIG00000114 110 23 112 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_4506_5046_5337_- FIG00719736 4 2 7 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_4526_1274_2020_+ FIG00000381 138 24 139 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_unique_4526_3008_3145_+ FIG00000210 30 5 30 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_4526_5061_5327_+ FIG00129616 43 8 44 GTP-binding protein EngA Universal GTPases 2 T2D_unique_4532_672_902_- FIG00000055 8 3 10 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_4564_4823_5288_- FIG00000312 72 11 73 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_4583_1717_1980_- FIG00000128 7 4 9 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_4602_5063_5257_+ FIG00007514 15 4 17 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_4622_4674_4994_+ FIG00000762 29 6 32 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_4622_5096_5247_+ FIG00000762 10 3 11 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_4660_2394_3143_+ FIG00066575 159 24 160 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_4679_84_332_- FIG00075702 37 7 38 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_4756_961_1335_- FIG00001882 29 7 31 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_4774_2256_3116_+ FIG00000395 73 16 74 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_4786_1707_2033_+ FIG00046902 34 8 35 Glutamine synthetase, clostridia type (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_4786_4858_5004_+ FIG00017761 11 3 11 Biopolymer transport protein ExbD/TolR Ton and Tol transport systems 2 T2D_unique_4787_1_595_+ FIG00051439 38 9 40 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_4793_4956_5119_- FIG01955999 18 4 18 Starvation sensing protein RspB Carbon Starvation 1.21 T2D_unique_4801_2898_3281_- FIG00038456 43 8 45 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_4828_1423_2226_+ FIG00000139 133 22 134 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_4828_3780_4046_+ FIG00003012 55 8 56 His repressor CBSS-393121.3.peg.1913 1 T2D_unique_4870_4299_4997_+ FIG00067681 134 25 135 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_4926_1_205_- FIG00000121 17 5 18 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_4957_4558_4995_+ FIG01031896 40 9 41 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_4978_65_1015_+ FIG00000441 58 12 59 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_4978_1114_1431_+ FIG00000441 9 2 10 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_4978_4306_4668_+ FIG00002049 4 2 5 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_4978_4680_4973_+ FIG00018865 12 4 15 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_4993_781_1173_+ FIG00013638 3 2 5 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_4996_2719_2910_- FIG00000390 15 4 16 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_5013_2807_3004_+ FIG00010844 15 4 16 Flavodoxin Flavodoxin 1 T2D_unique_5029_4724_4959_- FIG00001583 40 8 40 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_5061_1716_1916_- FIG00000394 11 2 12 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_5065_1_186_- FIG00002252 43 7 43 Galactose/methyl galactoside ABC transport system, D-galactose-binding periplasmic protein MglB (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_5069_2775_3032_+ FIG00134060 26 5 27 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_5111_2575_2952_- FIG00000234 38 7 41 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_5123_4542_4905_- FIG00081563 10 3 12 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_5126_1379_1807_+ FIG00000211 62 12 63 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_5128_2868_3035_+ FIG00000308 11 2 12 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_5128_4054_4902_+ FIG00000308 111 21 113 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_5130_1618_2040_+ FIG00000165 52 11 53 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_5130_3089_3439_+ FIG00000165 63 12 64 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_5176_3813_4073_+ FIG00106663 43 7 44 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_5233_1947_2984_- FIG00000111 134 26 139 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_5233_4554_4837_- FIG00000130 24 6 24 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_5268_4433_4809_+ FIG00000139 102 14 102 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_5271_1973_2419_- FIG00000659 16 5 19 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_5309_3559_4008_+ FIG00003881 40 10 41 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_5309_4026_4331_+ FIG00003881 25 5 26 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_5312_3631_3951_- FIG00003555 4 2 6 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_5323_1_877_- FIG00000448 223 34 223 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_5323_907_1659_- FIG00000448 163 25 163 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_5339_3986_4773_- FIG00008941 43 10 44 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_5373_3415_3915_- FIG00000055 28 9 29 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_5377_513_830_+ FIG00000557 28 7 29 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_5377_3845_4024_+ FIG00001134 11 2 12 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_unique_5382_3977_4744_- FIG00719736 81 21 83 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_5387_974_1258_- FIG00000412 35 9 36 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_5397_900_1742_- FIG00000114 92 17 96 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_5425_4068_4723_+ FIG00004589 17 7 21 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_5445_1_464_+ FIG00001388 20 7 22 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_unique_5488_969_1106_- FIG00503691 23 4 23 Cadmium-transporting ATPase (EC 3.6.3.3) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_5515_4021_4218_+ FIG00000811 11 4 13 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_5515_4224_4663_+ FIG00000303 16 5 18 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_5572_4216_4634_- FIG00000040 20 6 22 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_5587_966_1190_- FIG00001337 5 2 6 Na(+)-translocating NADH-quinone reductase subunit A (EC 1.6.5.-) Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_5639_930_2048_+ FIG00018699 16 9 19 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_5648_1977_2471_- FIG00001189 36 9 38 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_5676_1483_1749_- FIG01260980 76 10 76 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_5681_1030_1344_+ FIG00000420 16 6 18 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_5694_422_877_- FIG00000211 46 11 47 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_5754_3786_4040_+ FIG00001094 15 4 16 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_5811_4251_4515_- FIG00000080 3 2 5 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_5861_3122_3505_- FIG00000141 16 5 18 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_5863_4102_4491_+ FIG00016555 7 4 9 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_5866_4081_4489_+ FIG00011537 25 5 27 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_5869_4128_4488_+ FIG00003788 3 4 7 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_5897_3193_4182_+ FIG00000866 182 30 184 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_5899_2826_3185_+ FIG00000198 34 6 35 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_5948_1_974_- FIG00002049 62 18 66 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_5969_88_579_- FIG00019251 119 19 120 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_5977_3500_3745_+ FIG00001133 14 3 15 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_unique_6032_140_967_+ FIG00000659 62 18 64 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_6066_962_1120_- FIG00080955 25 4 25 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_6066_1162_1476_- FIG00000394 57 10 57 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_6067_1_225_+ FIG00003555 10 3 12 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_6070_3919_4047_+ FIG00451095 14 3 14 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_6093_3978_4217_- FIG00000421 24 5 25 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_6123_1888_2523_- FIG00037943 9 5 11 Transcription antitermination protein UpdY Transcription factors bacterial 1 T2D_unique_6142_1942_2172_+ FIG01260980 16 3 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_6153_3532_3933_+ FIG01318274 14 5 15 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_6153_4015_4347_- FIG00007339 26 6 27 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_6161_3090_4166_+ FIG00000352 210 33 211 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_6199_1_132_- FIG00018396 15 3 15 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_6215_4029_4317_+ FIG00000350 4 2 6 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_6237_1472_2164_+ FIG00000659 16 8 18 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_6273_1296_1493_- FIG00001676 22 4 24 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_6290_2932_3867_- FIG00000560 73 15 74 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_6337_4069_4265_+ FIG00000704 46 7 46 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_6348_2668_3069_+ FIG00046929 8 4 10 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_6358_2371_2973_- FIG00000273 66 15 67 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_unique_6360_4021_4254_+ FIG00001054 21 5 22 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_6408_3941_4237_- FIG00000401 50 9 51 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_6430_1164_1490_+ FIG00000877 14 4 15 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_6442_1_344_+ FIG00064110 16 5 17 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_6464_3201_4040_+ FIG00012683 15 5 17 NLP/P60 family protein CBSS-393121.3.peg.2760 1 T2D_unique_6470_4032_4210_+ FIG00000184 9 2 10 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_6473_3376_4134_- FIG00133227 3 2 5 N-acetylneuraminate lyase (EC 4.1.3.3) Sialic Acid Metabolism 1.x T2D_unique_6544_1692_2171_+ FIG00000793 31 7 32 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_6552_1984_2214_- FIG00018457 6 4 7 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_6552_3989_4171_- FIG00139333 13 3 15 4'-phosphopantetheinyl transferase (EC 2.7.8.-) [enterobactin] siderophore Siderophore Enterobactin 8 T2D_unique_6560_2049_2999_+ FIG00000157 128 25 130 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_6604_1_439_- FIG00000103 27 5 28 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_6616_1_554_+ FIG00000446 18 6 19 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_6630_1_316_- FIG00000290 36 7 37 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_6641_1_317_- FIG00006955 8 2 10 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_6642_2976_3974_- FIG01260980 31 10 35 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_6665_2511_3077_+ FIG00008941 103 15 104 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_6704_2342_2953_- FIG00001067 12 3 15 Rubrerythrin Oxidative stress 1.2 T2D_unique_6744_3696_4046_+ FIG00000080 32 6 33 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_6792_1705_1998_+ FIG01260980 27 6 28 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_6796_81_575_- FIG00095112 124 18 126 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) DNA-replication 4 T2D_unique_6804_831_1034_+ FIG00000388 27 5 28 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_6842_3848_4003_+ FIG00018396 5 3 7 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_6863_3763_3972_- FIG00001067 11 3 12 Rubrerythrin Oxidative stress 1.2 T2D_unique_6882_1_240_- FIG00134167 13 4 17 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_6916_1_1063_+ FIG00000494 45 12 47 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_6936_1_126_+ FIG00000578 10 3 11 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_6936_1566_1910_+ FIG00000770 31 7 32 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_6955_1_387_- FIG01007502 23 9 27 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_6982_2055_2336_+ FIG00000013 7 3 9 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_7092_1473_1928_- FIG00022568 3 3 5 Phosphonate ABC transporter ATP-binding protein (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_7112_656_1171_+ FIG00061313 5 3 6 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_7124_1130_1333_+ FIG00067300 6 2 8 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_7130_1872_2024_+ FIG00080955 19 5 21 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_7134_1548_1922_- FIG00000782 9 3 12 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_7134_1952_2698_- FIG00000782 61 13 63 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_7272_479_718_- FIG00001505 30 6 31 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_7339_1_267_+ FIG01956356 26 6 27 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_7357_974_1531_- FIG00001067 46 9 47 Rubrerythrin Oxidative stress 1.2 T2D_unique_7365_2916_3242_- FIG00000017 10 3 12 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_7398_1255_1974_- FIG00000782 47 14 50 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_7398_2221_2943_- FIG00132801 31 9 34 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_7398_2961_3401_- FIG00132801 9 3 11 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_7409_3533_3829_- FIG00003535 9 3 10 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_7422_286_867_+ FIG00000256 14 5 16 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_7492_1923_2783_- FIG00001548 54 12 55 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_7492_2846_3802_- FIG00001548 84 19 87 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_7523_3402_3796_+ FIG00000243 55 11 56 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_7540_1_312_+ FIG00138468 21 6 23 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_7544_1_459_- FIG00091940 21 6 22 Histidine ammonia-lyase (EC 4.3.1.3) Histidine Degradation 1.100 T2D_unique_7551_3410_3789_+ FIG00001129 15 5 17 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_unique_7554_1475_1891_- FIG01260980 11 5 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_7554_1927_2964_- FIG01260980 86 20 88 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_7577_1612_2085_+ FIG00132617 12 4 14 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_7619_961_1800_- FIG00018865 11 8 13 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_7621_1_831_- FIG00000147 52 11 55 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_7621_2933_3265_- FIG00000146 42 7 43 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_7765_2214_2945_- FIG00035412 6 5 13 BatC CBSS-345072.3.peg.1318 1 T2D_unique_7798_1_608_- FIG00020185 21 6 23 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_7798_1994_2410_- FIG00003435 32 7 34 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_7850_3362_3690_+ FIG00000151 75 12 76 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_7852_1_1035_+ FIG00001548 209 34 210 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_7875_1_583_- FIG00002914 3 4 6 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_7910_2973_3670_+ FIG00003472 57 14 59 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_7918_554_1060_+ FIG00004078 30 6 31 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_7928_1038_2003_+ FIG00009682 50 16 53 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_7933_3374_3663_+ FIG00018536 20 6 21 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_7978_2500_2973_- FIG00040817 36 9 37 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_8018_1_224_- FIG00104848 6 4 7 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_8018_2767_2934_- FIG00010508 10 4 11 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_8051_1094_1531_+ FIG00000116 15 7 17 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_8064_3421_3629_+ FIG00000086 41 7 41 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_8083_3205_3623_- FIG00000329 36 7 37 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_8094_3284_3620_- FIG00001054 11 5 13 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_8165_1_468_+ FIG00016110 15 5 17 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_8190_941_1252_- FIG00000477 3 2 5 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_8195_1344_1841_- FIG00000288 17 5 18 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_8218_1177_2043_+ FIG00475203 224 32 225 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_8220_2469_2894_- FIG00018865 27 8 28 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_8226_962_1489_- FIG00086697 11 4 13 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_8228_1_913_+ FIG00000777 16 7 19 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_8273_2993_3139_- FIG00000075 33 5 33 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_8294_2848_3566_- FIG00000402 38 9 41 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_8333_1_367_+ FIG00051001 68 11 68 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Biotin biosynthesis 1X T2D_unique_8342_1_1029_+ FIG00028203 192 31 194 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_8346_1_263_- FIG00719736 3 2 4 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_8389_3075_3538_+ FIG00000446 72 13 73 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_8421_3268_3530_- FIG00000080 22 5 24 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_8443_3040_3522_+ FIG00108342 32 9 33 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_8465_1_302_- FIG00009564 9 2 11 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_8470_359_919_- FIG00133325 18 5 19 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_8479_1108_1512_+ FIG00000494 27 6 28 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_8483_3385_3512_- FIG00001145 5 2 6 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_8484_2503_3000_+ FIG00098273 41 8 42 Glycine/sarcosine/betaine reductase component C chain 2 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_8484_3060_3467_+ FIG00098273 29 7 30 Glycine/sarcosine/betaine reductase component C chain 2 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_8505_1_201_+ FIG00135554 35 7 35 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_8506_3047_3507_+ FIG00024930 79 15 79 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_8528_3021_3500_+ FIG00000782 25 7 26 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_8589_786_956_- FIG00004078 28 5 28 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_8729_300_1022_+ FIG01016270 95 17 96 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_8740_2738_3016_+ FIG00129616 38 6 39 GTP-binding protein EngA Universal GTPases 2 T2D_unique_8835_3276_3422_- FIG00000102 12 3 13 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_8838_1_277_- FIG00000146 49 9 51 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_8839_2667_2978_- FIG00008490 19 4 20 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_8839_2987_3422_- FIG00008490 45 9 46 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_8899_629_1216_+ FIG00000269 96 15 98 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_8899_3043_3409_+ FIG00000085 24 4 25 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_8909_2927_3407_- FIG01260980 55 11 56 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_8927_1_224_- FIG00005705 11 3 18 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_unique_8928_220_669_+ FIG00001980 66 13 67 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_8932_3233_3401_- FIG00004502 6 2 7 5'-nucleotidase YjjG (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_8944_2963_3398_- FIG00009682 67 13 69 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_9046_2818_3367_- FIG00138258 101 15 103 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_9051_746_898_- FIG00001385 15 3 17 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_9064_129_1013_+ FIG00000420 19 12 23 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_9064_2006_2347_+ FIG00000437 34 7 35 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_9068_3022_3364_+ FIG00133229 11 3 12 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_9102_677_1009_+ FIG00000267 8 3 9 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_9112_2701_2919_- FIG00005727 5 2 6 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_9131_1906_3347_- FIG00001548 39 12 42 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_9170_796_1557_- FIG00000175 36 8 39 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_9173_678_1025_- FIG00134889 9 4 10 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_9173_2917_3138_- FIG00000556 12 2 14 2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55) Chorismate Synthesis 1 T2D_unique_9181_1131_2006_+ FIG00000446 45 15 47 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_9181_2136_2852_+ FIG00000208 26 11 28 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_9181_2863_3009_+ FIG00026918 11 4 12 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_9230_3087_3328_+ FIG00000377 29 7 31 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_9298_2979_3209_- FIG00000380 9 2 10 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_9299_1_921_- FIG00038456 208 33 208 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_9299_951_1229_- FIG00038456 51 8 53 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_9299_2321_2968_- FIG00000089 154 25 154 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_9338_2211_2537_+ FIG00000102 55 11 56 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_9406_127_369_- FIG00015082 4 2 5 Prevent host death protein, Phd antitoxin Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_9409_1945_2310_- FIG00000624 31 6 34 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_9410_965_1927_- FIG01960485 28 16 31 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_9447_1983_2351_- FIG00013156 16 5 18 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_9447_2375_2902_- FIG00013592 6 5 8 Putative ABC transporter (ATP-binding protein), spy1791 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_9459_1900_2229_- FIG01955011 5 2 6 Hypothetical protein DUF454 Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_9467_1_482_+ FIG00000070 26 7 27 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_9502_1138_1365_+ FIG00946436 14 4 16 Gluconate transporter family protein D-gluconate and ketogluconates metabolism 1.3 T2D_unique_9534_41_910_- FIG00001269 66 18 68 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_9534_964_1959_- FIG00001269 97 22 99 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_9551_3017_3255_+ FIG00000578 20 5 22 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_9576_3112_3252_+ FIG00001687 6 2 7 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_9588_976_1893_- FIG00001548 8 4 12 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_9588_1956_2453_- FIG00001548 19 7 20 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_9588_2498_2971_- FIG00004078 29 5 30 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_9588_2980_3249_- FIG00004078 8 4 9 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_9591_1_467_- FIG00060517 44 10 45 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_9597_3027_3248_+ FIG00096593 10 3 12 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_9662_1027_1608_+ FIG00012267 15 6 17 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_9662_2058_2822_+ FIG00004788 68 15 69 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_9702_3044_3226_+ FIG00001548 15 5 16 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_9705_2900_3046_+ FIG00005510 18 3 19 RND efflux system, outer membrane lipoprotein, NodT family Multidrug Resistance Efflux Pumps 1.12 T2D_unique_9762_1159_1647_+ FIG00475203 3 2 5 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_9768_2958_3213_- FIG00002914 34 6 35 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_9829_1_464_+ FIG00040528 11 4 13 Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282) Quinate degradation 3 T2D_unique_9843_745_936_- FIG00080231 49 7 49 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_9843_2947_3194_- FIG00080231 47 8 47 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_9848_2906_3192_+ FIG00001292 5 2 6 D-alanine aminotransferase (EC 2.6.1.21) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_9864_2126_3007_+ FIG00000356 74 14 75 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_9873_1979_2965_- FIG00047414 50 16 51 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_9873_2992_3185_- FIG00047414 3 2 4 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_9883_2980_3183_- FIG00000329 27 5 28 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_9885_1292_2062_+ FIG00000659 47 13 49 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_9931_716_985_- FIG00044622 3 2 4 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_9933_2932_3171_- FIG00010600 13 3 14 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_9940_1_862_- FIG00000287 138 25 139 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_9961_3014_3166_+ FIG00000476 5 3 17 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_9977_1358_1969_+ FIG00004655 13 4 14 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_9990_58_279_+ FIG00004843 53 8 53 Protein YidD Cell Division Subsystem including YidCD 1 T2D_unique_10038_2071_2568_- FIG00000155 55 14 56 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_10038_3001_3153_- FIG00001577 19 4 20 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_10043_1_651_+ FIG00002541 69 13 71 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_10048_990_1373_- FIG00003472 35 9 37 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_10093_2311_3145_- FIG00001562 25 7 26 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_unique_10115_1238_1465_+ FIG00012267 22 6 23 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_10143_2977_3133_- FIG01955850 13 3 15 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_10147_355_1224_+ FIG00017190 42 10 44 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_10181_116_775_- FIG00048580 9 6 10 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_10240_309_845_+ FIG00001067 79 16 80 Rubrerythrin Oxidative stress 1.2 T2D_unique_10242_1_1063_+ FIG01260980 259 35 260 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_10252_2305_3018_+ FIG00000990 75 16 77 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_10360_992_1246_- FIG00006988 71 9 72 FIG006988: Lipase/Acylhydrolase with GDSL-like motif CBSS-370552.3.peg.1240 1 T2D_unique_10360_1416_1886_- FIG00005590 105 18 105 Hypothetical protein DUF194, DegV family CBSS-370552.3.peg.1240 1 T2D_unique_10360_1910_2254_- FIG00005590 53 10 54 Hypothetical protein DUF194, DegV family CBSS-370552.3.peg.1240 1 T2D_unique_10360_2476_3091_- FIG00000317 129 19 130 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_10386_56_913_- FIG00000404 58 14 61 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_10452_2045_3064_+ FIG00000494 17 8 20 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_10479_1523_2038_+ FIG00000134 25 6 26 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_10573_2690_3054_+ FIG00000412 63 11 64 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_10597_1355_1972_- FIG00001824 58 14 59 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_10612_2632_3046_+ FIG00000985 17 5 18 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_10684_1_539_+ FIG00003129 121 19 124 Galactose operon repressor, GalR-LacI family of transcriptional regulators Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_10703_395_979_- FIG00002053 49 13 51 Na(+)-translocating NADH-quinone reductase subunit D (EC 1.6.5.-) Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_10720_1730_2107_+ FIG00052605 13 3 15 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_10721_811_1083_+ FIG00002742 7 2 8 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_10721_2722_3024_+ FIG00133569 73 10 74 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_10724_2690_3024_+ FIG00000001 14 6 15 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_10769_1_370_- FIG00064110 26 9 27 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_10834_2672_3004_+ FIG00001385 32 6 34 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_10842_1130_1690_+ FIG00044622 81 15 83 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_10842_1713_1997_+ FIG00000897 12 4 14 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_10874_2550_2997_+ FIG00000372 41 8 43 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_10875_2723_2997_- FIG00080231 62 10 62 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_10904_2133_2780_- FIG01955850 50 11 53 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_10911_1_847_- FIG00093180 193 29 194 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_10918_1_939_- FIG00019868 243 35 244 Maltose/maltodextrin ABC transporter, permease protein MalF Maltose and Maltodextrin Utilization 1.x T2D_unique_10937_2698_2987_+ FIG00012746 6 3 8 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_10948_1_792_- FIG00000185 182 28 184 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_10951_1121_2026_+ FIG00000333 78 19 80 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_10963_1986_2174_- FIG00003460 3 3 4 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_10967_1_327_- FIG00006500 80 12 81 Hybrid sensory histidine kinase in two-component regulatory system with EvgA Orphan regulatory proteins 1 T2D_unique_10973_1866_2162_- FIG00041038 11 3 13 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_11042_1217_2029_+ FIG00000476 28 8 30 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_11046_335_739_- FIG00016514 52 11 53 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_11080_1_446_+ FIG00000832 93 14 94 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_unique_11131_60_785_- FIG00129130 35 12 38 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_11131_947_1393_- FIG00129130 14 6 16 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_11241_987_1295_- FIG00015230 45 8 46 Outer membrane porin protein NmpC precursor Uptake of selenate and selenite 1.1 T2D_unique_11291_1_1001_+ FIG00018392 46 12 48 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_unique_11329_1_436_+ FIG00000314 85 16 86 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_11329_454_1146_+ FIG00000352 118 20 119 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_11329_1152_1472_+ FIG00000352 77 12 77 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_11329_1487_2203_+ FIG00013339 107 17 109 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_11365_1_676_+ FIG00000036 40 12 42 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_11365_2014_2778_+ FIG00000140 30 9 32 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_11382_1_239_- FIG00003955 29 7 31 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_11390_1_842_- FIG00000085 106 21 107 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_11390_968_1582_- FIG00000085 85 16 86 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_11432_1_401_- FIG00001732 18 3 20 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_11438_973_1293_- FIG00001449 52 11 53 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_unique_11535_2046_2426_+ FIG00000209 69 13 70 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_unique_11541_2479_2884_- FIG00016514 27 7 28 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_11555_1_302_- FIG00000877 26 7 27 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_11574_1_396_- 16 4 18 FIG009210: peptidase, M16 family CBSS-257314.1.peg.676 4.x T2D_unique_11576_1466_2089_+ FIG00000151 34 7 36 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_11612_845_1054_+ FIG00001504 11 2 12 Serine--glyoxylate aminotransferase (EC 2.6.1.45) Serine-glyoxylate cycle 1 T2D_unique_11672_35_646_- FIG00003520 100 19 102 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_11680_1042_1917_+ FIG00002239 14 6 17 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_11689_135_1001_+ FIG00000476 59 14 61 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_11689_1025_2035_+ FIG00000476 76 18 77 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_11689_2149_2418_+ FIG00000476 29 7 30 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_11689_2430_2862_+ FIG00028461 25 6 26 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_11722_749_1042_+ FIG00001175 7 4 10 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_11722_1051_1407_+ FIG00001175 27 6 29 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_11744_1952_2854_- FIG00000356 102 23 104 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_11752_1_330_+ FIG00002110 60 10 61 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_11766_1_209_- FIG00003506 12 2 13 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_11774_1338_2051_+ FIG00093180 155 22 156 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_11780_1_1045_+ FIG00001548 64 14 67 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_11780_2418_2849_+ FIG00001548 14 3 17 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_11786_1568_1972_- FIG00089870 5 4 9 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_unique_11786_1996_2848_- FIG00089870 94 18 95 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_unique_11789_864_1031_+ FIG01956356 13 3 13 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_11791_1_286_+ FIG01260980 50 9 51 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_11793_2256_2714_+ FIG00006700 3 2 5 RNA binding protein, contains ribosomal protein S1 domain Cell division-ribosomal stress proteins cluster 1 T2D_unique_11806_1598_2743_- FIG00000372 161 27 164 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_11809_1978_2844_- FIG00000422 106 22 107 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_11849_1280_2251_+ FIG00017190 189 28 191 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_11870_498_959_- FIG00004763 54 9 57 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_11890_900_1595_+ FIG00074225 4 3 6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_11929_2452_2826_- FIG00135554 95 15 96 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_11941_2451_2825_- FIG00000314 25 6 26 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_11947_1157_1519_+ FIG00000832 20 6 22 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_unique_11959_1_153_+ FIG00020185 3 2 4 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_11967_2546_2821_+ FIG00003086 18 5 20 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_11968_1101_1664_+ FIG00026918 14 5 15 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_12011_1_243_+ FIG01297554 69 9 69 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_12027_993_1373_- FIG00004170 3 2 5 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_12042_563_1006_+ FIG00000720 19 5 21 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_12048_2675_2810_+ FIG00000477 10 3 11 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_12085_1_333_- FIG00006151 67 12 67 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_12136_1_519_+ FIG00000747 128 20 129 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_12150_226_951_- FIG00063189 164 26 164 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_12166_860_1045_+ FIG00041038 17 3 18 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_12182_2192_2789_+ FIG00026918 44 11 45 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_12203_2224_2580_- FIG00028476 58 8 60 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_12223_1_268_- FIG00000522 24 4 25 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_12232_769_1008_+ FIG00000209 27 7 27 SSU ribosomal protein S7p (S5e) Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins) 1.x T2D_unique_12238_1_407_- FIG00062547 5 2 10 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_12238_415_957_- FIG00229199 80 16 81 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_12261_2304_2777_- FIG00008294 5 4 7 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_12286_609_815_+ FIG00044622 11 3 12 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_12331_1_305_+ FIG00037431 16 5 18 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_12371_1159_1992_- FIG00004589 82 15 85 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_12380_1_595_+ FIG00008304 76 11 78 Aspartate 1-decarboxylase (EC 4.1.1.11) Coenzyme A Biosynthesis A.191 T2D_unique_12401_2220_2758_+ FIG00000392 17 4 19 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_12418_163_420_- FIG00000394 4 2 6 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_12420_875_1063_+ FIG00001088 24 5 26 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_12420_2373_2564_+ FIG00001088 38 7 38 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_12516_2428_2743_+ FIG00046929 7 4 9 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_12522_120_1028_+ FIG00009682 11 7 15 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_12536_1_143_- FIG00011114 9 3 10 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_12571_2337_2735_- FIG00044622 76 14 78 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_12573_1_873_- FIG00013525 5 2 7 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_unique_12591_684_1019_+ FIG00005172 16 3 17 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_12591_2523_2732_+ FIG00006551 10 4 12 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_12615_1_1016_+ FIG00067681 247 37 248 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_12650_2532_2724_+ FIG00001269 44 6 44 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_12666_2033_2440_+ FIG00028694 4 3 5 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_12667_2099_2722_+ FIG00000134 156 22 157 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_12678_2592_2721_+ FIG00000185 5 2 7 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_12685_1964_2720_- FIG00000097 183 29 183 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_12702_1981_2718_- FIG00013626 19 7 21 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_12721_2422_2715_- FIG00000202 25 7 26 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_12726_123_1067_+ FIG01266244 210 30 211 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_12747_1289_1648_+ FIG01304636 67 11 68 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_12760_2531_2708_+ FIG00000017 8 2 9 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_12782_1_974_- FIG00000636 156 30 160 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_12806_1040_1999_+ FIG00001166 7 3 9 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_12834_323_664_+ FIG00000214 81 13 81 LSU ribosomal protein L19p Ribosome LSU bacterial 9 T2D_unique_12836_2008_2553_+ FIG00003530 20 7 25 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_12852_1_362_- FIG00002470 20 6 27 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_12899_652_888_+ FIG00002328 14 4 16 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_12934_1730_2131_+ FIG00022300 51 9 52 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_12937_1972_2685_- FIG00010134 76 14 78 Methionine transporter MetT Methionine Degradation 3 T2D_unique_12968_2155_2502_+ FIG00002161 45 9 46 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_unique_12973_1_335_+ FIG00000065 58 11 59 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_12984_1_641_- FIG00000522 108 19 109 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_12999_1_752_+ FIG00002251 71 13 73 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_13013_1006_2076_+ FIG00075702 73 20 75 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_13057_1_988_- FIG00229386 273 39 273 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_13057_1214_1930_- FIG00846773 188 29 188 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_13057_1951_2082_- FIG00846773 19 3 19 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_13065_1161_1466_+ FIG00004078 13 4 14 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_13096_1746_2030_+ FIG00000219 48 7 49 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_13102_2050_2661_+ FIG00046929 6 4 8 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_13107_516_950_- FIG00057709 99 17 99 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_13107_1403_1855_- FIG00000175 107 18 107 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_13129_1779_1973_- FIG00000382 13 2 14 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_13129_1994_2266_- FIG00000382 29 6 30 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_13149_1518_1841_- FIG00530360 14 4 16 DUF324 domain-containing protein CRISPR-associated cluster 1 T2D_unique_13152_1_650_- FIG00022899 123 21 123 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_13193_1_491_- FIG00000102 123 19 123 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_13193_496_792_- FIG00001489 73 11 73 ribosomal protein L7Ae family protein Transcription factors bacterial 1 T2D_unique_13195_1_1087_- FIG00080955 79 18 81 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_13195_1982_2649_- FIG00000402 59 14 61 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_13197_1_1015_+ FIG00075702 114 27 116 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_13208_1511_1834_- FIG01307086 26 5 26 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_13235_2407_2595_- FIG00000840 7 2 8 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_13237_623_1078_+ FIG00000863 49 12 51 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_13244_641_1003_+ FIG00000113 25 7 26 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_13302_2049_2633_+ FIG00000086 34 9 35 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_13312_2284_2631_- FIG00000552 77 13 78 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_13344_2283_2627_+ FIG00005647 12 3 14 Chemotaxis protein CheD Bacterial Chemotaxis 9 T2D_unique_13354_736_1005_+ FIG00016110 19 5 20 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_13371_1_606_+ FIG00001548 50 9 55 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_13456_1879_2577_- FIG00000476 9 6 12 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_13458_627_1193_+ FIG00001414 19 5 22 Cell division initiation protein DivIVA Cell Division Cluster 1.x T2D_unique_13468_1_641_+ FIG00011468 53 11 56 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_13478_420_1238_- FIG00031250 3 5 11 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_13483_1980_2195_- FIG00000614 20 6 21 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_unique_13499_2319_2609_- FIG00064110 34 8 36 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_13509_422_769_+ FIG01260980 14 3 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_13535_1_510_+ FIG00028203 103 17 103 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_13535_547_1047_+ FIG00000080 72 13 73 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_13535_1077_2042_+ FIG00000080 179 30 180 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_13537_1992_2606_- FIG00945384 3 3 5 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_13544_64_555_+ FIG00127025 41 11 44 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_13544_615_944_- FIG00002300 13 4 15 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_13545_1920_2605_- FIG00012683 16 4 18 NLP/P60 family protein CBSS-393121.3.peg.2760 1 T2D_unique_13551_2248_2604_+ FIG00044478 13 5 15 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_13552_983_1498_- FIG00024401 73 13 74 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_13624_2182_2594_+ FIG00011468 22 8 23 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_13694_1_925_+ FIG00064110 122 28 125 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_13707_562_819_- FIG00006332 24 4 25 Transcriptional antiterminator with PTS regulation domain, SPy0181 ortholog L-ascorbate utilization (and related gene clusters) 29 T2D_unique_13722_2188_2582_+ FIG00023004 99 15 99 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_13734_2259_2580_+ FIG00001548 17 6 18 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_13738_1_363_+ FIG00000532 24 7 26 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_13738_371_1075_+ FIG00022300 16 3 18 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_13742_164_781_- FIG00001670 64 13 66 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_13748_1204_2010_+ FIG00138208 58 13 60 Glycolate dehydrogenase (EC 1.1.99.14), subunit GlcD Glycolate, glyoxylate interconversions ? T2D_unique_13822_935_1180_- FIG00005464 10 3 11 Ascorbate-specific PTS system, EIIA component (EC 2.7.1.-) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_13829_744_1010_+ FIG00005924 6 2 7 Excinuclease ABC subunit A paralog in greater Bacteroides group DNA repair, UvrABC system 1 T2D_unique_13830_2038_2570_- FIG01290653 25 7 32 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_13850_981_1157_- FIG01260980 5 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_13875_2073_2565_+ FIG00000412 137 20 137 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_13886_2264_2564_- FIG00139192 11 3 12 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_13890_1_1024_+ FIG00008736 4 5 9 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_13906_1_497_- FIG00000645 78 14 79 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_13906_1992_2561_- FIG00000897 14 4 15 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_13907_1_177_- FIG00002385 10 2 11 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_13907_388_858_- FIG00001676 14 8 16 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_13907_942_1259_- FIG00001803 4 2 5 Polyferredoxin NapH (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_13914_188_586_+ FIG00077620 42 11 43 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_13937_1952_2557_- FIG00135469 9 5 11 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_13994_1742_2059_+ FIG00000376 8 4 11 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_13998_130_348_- FIG00000143 33 7 34 Translation initiation factor 1 Translation initiation factors bacterial 1.111 T2D_unique_13998_1119_1766_- FIG00000089 82 15 83 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_14005_995_1393_- FIG00000421 41 9 42 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_14005_1957_2550_- FIG00001189 87 14 89 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_14039_1953_2246_- FIG01955803 64 10 64 NAD-dependent formate dehydrogenase gamma subunit Formate hydrogenase 3.1?? T2D_unique_14101_2301_2495_+ FIG00000391 39 7 39 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_14102_970_1281_- FIG00000557 20 6 21 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_14109_2256_2537_+ FIG00001306 71 11 71 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_unique_14147_263_922_+ FIG00000047 152 25 152 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_14147_1010_1546_+ FIG00001175 146 21 146 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_14147_1553_2029_+ FIG00000595 102 17 103 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_14147_2035_2533_+ FIG00000595 91 13 92 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_14167_1976_2137_- FIG00000381 23 4 25 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_unique_14261_2029_2519_+ FIG00000088 31 6 33 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_14278_2000_2516_+ FIG00132976 52 11 54 Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33) Acetoin, butanediol metabolism 5 T2D_unique_14327_2348_2513_+ FIG00129616 5 2 6 GTP-binding protein EngA Universal GTPases 2 T2D_unique_14332_2023_2513_+ FIG00016061 55 10 59 L-lactate permease Lactate utilization 3 T2D_unique_14406_2262_2505_+ FIG00000032 47 9 47 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_14427_2056_2503_+ FIG00134486 94 15 95 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_14450_1_396_+ FIG01290653 83 14 83 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_14487_929_1108_- FIG00340292 11 3 12 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_14495_1_641_+ FIG00025216 15 4 17 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_14506_567_947_- FIG00000897 33 7 34 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_14513_781_1068_+ FIG00000367 16 4 17 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_14528_1971_2210_- FIG00000173 44 8 44 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_14532_2123_2492_+ FIG00019251 3 2 5 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_14552_1983_2490_- FIG00018699 53 10 55 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_14591_2216_2486_- FIG00000267 76 11 76 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_14607_2133_2484_+ FIG00000139 3 2 4 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_14609_1_599_- FIG00000163 63 15 64 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_14689_1_910_+ FIG00000552 89 17 91 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_14696_1_826_- FIG00000402 12 4 15 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_14696_1042_1191_+ FIG00015476 11 3 13 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_unique_14733_1029_1547_+ FIG00000047 48 14 50 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_14733_1953_2189_+ FIG00001175 10 3 11 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_14737_1756_2025_+ FIG00000866 53 9 53 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_14737_2097_2444_+ FIG00000866 82 12 83 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_14811_1033_2187_+ FIG00002744 36 10 40 Glycogen branching enzyme, GH-57-type, archaeal (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_14832_1417_2082_+ FIG00000494 33 7 35 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_14833_978_1559_- 4 3 6 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Alkanesulfonate assimilation 9.? T2D_unique_14835_2003_2461_- FIG00047414 4 2 7 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_14842_378_1067_+ FIG00000323 31 9 33 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_14842_2292_2461_+ FIG00000877 5 2 6 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_14844_1941_2461_+ FIG00000001 19 6 22 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_14889_1_192_+ FIG00000517 6 2 7 Iron-sulfur cluster-binding protein Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_14914_2049_2453_+ FIG00000224 21 8 22 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_14928_1690_1983_- FIG00001980 16 4 17 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_14952_1962_2378_- FIG00000440 34 6 35 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_unique_15010_2026_2229_+ FIG00000190 19 5 20 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_15089_2085_2437_- FIG00141373 16 4 17 Regulatory protein SusR Cellulosome 1.x T2D_unique_15124_2010_2434_+ FIG00011236 93 15 94 Phosphomevalonate kinase (EC 2.7.4.2) Isoprenoid Biosynthesis 2.x T2D_unique_15131_177_974_- FIG00000380 240 32 240 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_15131_998_1978_- FIG00000380 277 40 277 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_15131_2017_2433_- FIG00000356 78 13 79 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_15135_280_1002_+ FIG00000402 22 9 25 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_15147_759_1037_+ FIG00000494 21 5 22 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_15174_2124_2429_- FIG00000122 62 10 63 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_15201_1948_2427_- FIG00000645 80 13 81 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_15204_1151_1477_+ FIG00046929 65 12 65 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_15205_2114_2427_+ FIG00002470 11 3 13 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_15210_1_766_+ FIG00000442 187 29 187 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_15217_2126_2425_- FIG00001020 5 2 7 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_15218_366_947_- FIG00002561 21 7 23 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_15244_348_878_- FIG00000264 50 12 51 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_unique_15258_1204_1560_- FIG00005283 33 7 34 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_15274_1957_2420_- FIG00846773 28 6 29 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_15302_1_717_+ FIG00016514 43 10 44 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_15335_1990_2283_- FIG00017190 24 6 26 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_15380_625_1029_+ FIG00000838 7 4 8 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_15429_1466_1753_- FIG00003472 18 4 19 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_15456_1_354_+ FIG00024930 13 2 14 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_15475_1_609_- FIG00059881 5 3 7 Transmembrane component NikQ of energizing module of nickel ECF transporter ECF class transporters 345678 T2D_unique_15493_184_942_- FIG00000803 8 6 18 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_unique_15509_976_1743_- FIG00000070 55 14 56 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_15510_1_1001_+ FIG00001088 17 6 21 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_15568_1227_1835_+ FIG00000397 22 9 25 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_15568_2225_2394_+ FIG00000620 6 2 7 Phosphoheptose isomerase (EC 5.3.1.-) CBSS-160492.1.peg.550 1 T2D_unique_15601_1_507_+ FIG00000303 8 2 9 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_15626_1988_2389_- FIG00028476 13 3 14 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_15652_1_369_- FIG00001547 8 2 9 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_15679_1848_2384_- FIG00002205 4 3 6 DNA helicase IV DNA repair, bacterial UvrD and related helicases 1 T2D_unique_15689_429_620_- FIG00093180 10 3 13 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_15691_1836_2060_+ FIG00002463 16 3 18 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_15691_2126_2384_+ FIG00002463 26 5 27 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_15705_2027_2382_+ FIG00132839 24 6 29 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_15750_1997_2275_+ FIG00000323 8 4 9 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_15759_1896_2377_- FIG00058830 52 10 54 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_15760_1041_1475_+ FIG00037431 3 2 5 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_15770_1838_1993_+ FIG00719736 31 5 31 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_15818_607_960_- FIG00058830 14 4 15 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_15828_107_892_- FIG00000962 26 9 28 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_15828_1999_2370_- FIG00001518 3 3 4 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_15876_2079_2365_+ FIG00000328 10 4 12 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_15885_1914_2365_- FIG00000402 14 3 16 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_15928_2062_2361_+ FIG00001469 12 3 14 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_15970_1291_1716_+ FIG00000494 35 7 36 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_15974_814_945_- FIG00002020 20 3 21 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_16031_560_1162_+ FIG00000290 28 13 29 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_16041_1474_1971_- FIG00000822 111 18 111 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_16041_2146_2351_- FIG00000832 49 8 49 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_unique_16046_1154_1762_+ FIG00000267 10 5 12 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_16046_1765_2058_+ FIG00052300 10 5 11 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_16053_1773_2054_+ FIG00000191 15 5 17 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_16053_2060_2350_+ FIG00000191 7 3 9 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_16087_1633_1896_- FIG00000402 7 2 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_16092_2073_2347_+ FIG00001647 31 8 32 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_16297_1924_2331_- FIG00002470 26 7 28 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_16308_2144_2330_+ FIG00002239 44 6 44 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_16323_1994_2329_- FIG00000877 33 7 34 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_16337_1026_1871_- FIG00000087 42 12 44 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_16337_1892_2278_- FIG00000087 35 8 36 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_16357_1887_2327_- FIG00001269 32 8 33 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_16376_1680_1961_- FIG00007960 35 7 36 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_16388_1816_2043_+ FIG00561498 20 4 21 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_16388_2061_2324_+ FIG00561498 29 6 30 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_16401_1522_1767_- FIG00000477 10 3 12 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_16415_2110_2322_+ FIG00001604 35 6 36 Ornithine decarboxylase (EC 4.1.1.17) Polyamine Metabolism 2 T2D_unique_16428_1007_1465_+ FIG00000986 44 9 45 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_16431_1_1065_+ FIG00022899 64 15 73 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_16461_14_229_- FIG00009156 6 2 8 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_16489_951_1571_- FIG00002239 44 11 46 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_16492_1_377_- FIG00002385 15 7 18 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_16507_1742_1978_- FIG00141373 18 4 19 Regulatory protein SusR Cellulosome 1.x T2D_unique_16514_1226_1774_+ FIG00035226 131 20 131 Substrate-specific component NiaX of predicted niacin ECF transporter ECF class transporters 345678 T2D_unique_16527_1_253_+ FIG00003844 62 9 62 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_16555_1888_2310_- FIG00016768 12 4 13 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_16571_1197_1505_+ FIG00003174 7 2 8 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_16571_2101_2308_+ FIG00001548 14 3 15 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_16607_1_236_- FIG00035175 12 3 13 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_16607_239_418_+ FIG00000328 32 6 32 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_16617_2072_2304_+ FIG00000402 22 4 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_16650_976_1749_- FIG00018699 5 2 7 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_16671_1_1014_+ FIG00001076 130 24 131 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_16672_1561_1866_+ FIG01318274 11 3 15 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_16674_2049_2222_- FIG00000477 6 3 7 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_16735_1093_1527_+ FIG00000184 60 12 62 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_16796_793_1044_+ FIG00001656 3 2 5 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_unique_16811_1_179_+ FIG00017431 47 7 47 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_unique_16821_2055_2290_+ FIG00028694 3 3 5 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_16888_1_300_+ FIG00002412 13 5 15 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_unique_16951_118_963_+ FIG00000555 210 31 211 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_16951_1780_2061_+ FIG01955782 43 8 44 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_16981_1_695_+ FIG00001522 22 7 26 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_16985_57_950_- FIG00001385 239 35 241 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_16986_2021_2278_+ FIG00008286 45 9 45 Osmotically activated L-carnitine/choline ABC transporter, ATP-binding protein OpuCA Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_17020_2075_2275_+ FIG00000211 18 4 19 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_17053_1010_1753_+ FIG00000413 65 15 67 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_17057_1918_2273_- FIG00000095 6 4 8 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_17063_1_654_+ FIG00847536 22 7 24 Phage (Mu-like) virion morphogenesis protein Phage head and packaging 1 T2D_unique_17073_1984_2272_- FIG00000831 15 5 16 Na+/H+ antiporter NhaA type Na(+) H(+) antiporter 1 T2D_unique_17075_2078_2272_+ FIG00000087 17 4 18 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_17079_1080_1946_- FIG00038343 10 4 12 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_17092_1_333_- FIG00002034 7 3 8 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_17166_994_1602_- FIG00000695 32 8 34 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_17168_1003_2025_+ FIG00096593 92 20 94 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_17168_2064_2264_+ FIG00096593 8 3 9 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_17190_1_461_- FIG00000636 111 16 111 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_17233_1957_2257_- FIG00004763 35 7 37 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_17257_1946_2255_- FIG00001547 46 7 47 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_17262_2093_2255_- FIG00000333 11 4 12 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_17264_1243_1479_- FIG00000433 16 4 17 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_17270_959_1201_- FIG00000140 22 4 23 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_17272_1_167_- FIG00000156 5 2 5 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_17326_1_224_- FIG00003025 11 4 22 Sensory histidine kinase QseC Orphan regulatory proteins 1 T2D_unique_17341_526_870_- FIG00000421 44 7 46 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_17341_1632_2036_+ FIG00005587 20 5 22 Transcriptional regulator of rhamnose utilization, AraC family L-rhamnose utilization 1 T2D_unique_17383_1647_2060_+ FIG01304224 19 3 20 Large exoproteins involved in heme utilization or adhesion CBSS-316057.3.peg.3521 1 T2D_unique_17399_1619_2023_+ FIG00005547 12 3 14 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_unique_17399_2080_2244_+ FIG00000261 40 6 40 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_17425_2083_2242_+ FIG00451095 9 2 10 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_17430_1334_1933_- FIG00001530 85 16 86 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_17430_1984_2242_- FIG00001530 17 3 19 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_17440_1639_2034_+ FIG00023943 26 7 27 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_17450_1752_1925_- FIG00104848 12 2 13 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_17450_1982_2241_- FIG00104848 18 4 20 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_17507_1673_2041_+ FIG00004826 12 4 13 L-rhamnose-proton symporter L-rhamnose utilization 1 T2D_unique_17528_1977_2236_- FIG00009210 18 4 19 FIG009210: peptidase, M16 family CBSS-257314.1.peg.676 4.x T2D_unique_17542_665_1003_+ FIG00000156 9 4 11 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_17553_1_337_+ FIG00004170 87 12 88 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_17553_363_1097_+ FIG00000163 33 9 35 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_17553_1124_1273_+ FIG00000163 9 3 10 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_17566_1_542_+ FIG00031250 25 9 27 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_17574_981_1952_- FIG00001865 78 14 79 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_17603_787_1029_+ FIG00000555 49 7 49 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_17642_1_456_- FIG00024930 14 4 15 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_17663_1_364_+ FIG00006151 27 9 28 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_17687_1981_2223_- FIG00063189 42 7 43 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_17703_1_463_- FIG01260980 6 6 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_17705_1349_2086_+ FIG00000822 74 15 77 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_17717_1_239_+ FIG00000168 25 6 27 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_17717_815_1219_+ FIG00000102 41 7 43 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_17717_1468_2221_+ FIG00000102 129 20 131 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_17727_1122_1655_- FIG01305042 48 11 49 Phage terminase, small subunit Phage head and packaging 1 T2D_unique_17730_1_276_+ FIG00000108 9 3 10 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_17741_423_836_- FIG00001670 8 2 10 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_17790_1962_2216_- FIG00007941 23 4 25 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_17798_405_1073_+ FIG00000234 70 17 71 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_17812_1952_2214_- FIG00007941 6 2 8 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_17827_1_1122_+ FIG00001548 254 39 255 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_17830_1_455_- FIG00000329 92 17 93 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_17830_1912_2151_- FIG00000394 14 3 15 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_17831_1_894_+ FIG00006151 181 31 181 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_17837_1_173_+ FIG00022300 43 6 43 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_17883_1_263_- FIG00139589 55 8 56 Probable L-ascorbate-6-phosphate lactonase UlaG (EC 3.1.1.-) (L-ascorbate utilization protein G) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_17917_1_394_+ FIG00038920 47 8 49 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_17939_1990_2205_- FIG00093180 16 5 18 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_17946_1565_1969_- FIG00000477 18 5 20 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_17974_1_126_+ FIG00021289 31 5 31 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_17978_713_1129_+ FIG00000672 10 3 11 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_17978_1325_2086_+ FIG00475203 32 9 37 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_18030_1032_1238_+ FIG00004100 26 5 28 Cold shock protein CspA Cold shock, CspA family of proteins 1 T2D_unique_18031_1923_2199_- FIG00000709 39 7 40 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) Periplasmic disulfide interchange 1 T2D_unique_18096_1_304_- FIG00007304 70 11 70 Dipicolinate synthase subunit B Dipicolinate Synthesis 1 T2D_unique_18097_1915_2194_- FIG00904859 27 5 28 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_unique_18119_976_1149_- FIG00000053 6 2 7 LSU ribosomal protein L33p Ribosome LSU bacterial 9 T2D_unique_18119_1993_2192_- FIG00001269 9 2 10 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_18233_302_511_+ FIG01262685 50 8 50 Fructose-bisphosphate aldolase class I (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_18251_918_1670_- FIG00000474 168 26 168 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_18254_118_465_- FIG00000456 76 13 77 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_18295_46_876_+ FIG00001011 73 14 76 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_18326_903_1043_+ FIG00000111 14 3 16 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_18330_977_1486_- FIG00000494 11 4 14 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_18357_1_194_- FIG00034293 39 7 39 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_18394_134_994_- FIG00001561 20 7 22 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_18400_1645_1875_- FIG00000747 14 4 15 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_18440_1940_2169_- FIG00001469 3 3 4 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_18442_1980_2169_- FIG00010844 44 6 44 Flavodoxin Flavodoxin 1 T2D_unique_18445_1_572_+ FIG00080231 51 8 53 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_18485_369_1004_+ FIG00000372 142 22 142 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_18497_1837_2166_- FIG00002161 12 3 16 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_unique_18511_1_420_+ FIG00000720 41 8 42 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_18529_1976_2163_- FIG00000494 14 3 15 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_18532_45_941_- FIG00001120 216 34 216 Isopentenyl-diphosphate delta-isomerase, FMN-dependent (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_18534_270_860_- FIG00139238 35 8 36 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_18558_716_1015_+ FIG00000557 69 11 69 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_18602_1_927_- FIG00030191 43 10 45 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_18618_1988_2158_- FIG00001548 13 3 14 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_18675_1199_1882_- FIG00055520 9 3 11 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_18713_21_950_+ FIG00000421 207 30 208 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_18714_2020_2152_+ FIG00008736 20 4 20 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_18763_361_1323_- FIG00029758 35 6 36 N-carbamoyl-L-amino acid hydrolase (EC 3.5.1.87) Hydantoin metabolism 4 T2D_unique_18783_962_1441_- FIG00000532 51 13 52 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_18848_47_880_- FIG00000308 116 22 117 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_18848_964_1620_- FIG00000308 6 4 8 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_18848_1739_1975_- FIG00001563 17 3 18 Preprotein translocase subunit SecG (TC 3.A.5.1.1) Murein hydrolase regulation and cell death 1.2 T2D_unique_18946_734_1120_+ FIG00005022 10 2 12 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_18990_1_740_- FIG00004078 98 16 99 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_18990_938_1780_- FIG00004078 66 17 70 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_19027_1_362_- FIG01239241 78 13 78 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_19084_1750_1980_+ FIG00004843 48 7 48 Protein YidD Cell Division Subsystem including YidCD 1 T2D_unique_19086_1602_1949_- FIG00001548 94 13 95 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_19128_1438_2115_+ FIG00000404 142 22 144 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_19177_1_188_- FIG00074225 11 3 12 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_19215_263_1030_+ FIG00066425 76 17 78 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_19215_1132_1371_+ FIG00066425 31 7 32 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_19276_1_328_- FIG00002470 20 5 21 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_19290_1_909_- FIG00000287 119 20 120 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_19320_1100_2077_+ FIG00011057 39 11 43 Deoxyribonucleoside regulator DeoR (transcriptional repressor) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_19338_825_1118_+ FIG00001893 11 4 12 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_19422_402_833_- FIG00140053 99 16 99 PTS system, fructose- and mannose-inducible IIA component (EC 2.7.1.69) Fructose and Mannose Inducible PTS 2 T2D_unique_19422_1134_1967_- FIG00139508 224 33 224 periplasmic fructose-binding protein component of signal transduction system LevQ Fructose and Mannose Inducible PTS 2 T2D_unique_19439_1846_2013_+ FIG00000193 36 5 36 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_unique_19474_1029_1613_+ FIG00000494 20 4 22 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_19514_1738_2082_+ FIG00001882 41 8 42 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_19554_1_1132_+ FIG00000434 257 39 258 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_19554_1241_2041_+ FIG00000582 192 29 193 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_19612_1_379_- FIG01312219 6 2 9 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_unique_19612_1229_1927_- FIG00000175 41 9 44 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_19637_636_962_- FIG00000465 82 13 82 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_19637_989_1624_- FIG00000465 165 25 165 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_19640_199_933_- FIG00012683 38 10 39 NLP/P60 family protein CBSS-393121.3.peg.2760 1 T2D_unique_19650_125_421_+ FIG00080955 34 6 36 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_19676_1_485_+ FIG00009450 17 4 19 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_19676_1026_2060_+ FIG00066643 62 13 64 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_19688_1_250_- FIG00052730 66 10 66 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_19692_1452_2021_+ FIG01956071 5 4 7 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_unique_19715_1_707_+ FIG00000365 193 28 193 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_19736_1056_1598_+ FIG00006151 30 9 33 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_19738_878_1279_- FIG00719736 17 4 18 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_19751_1038_2003_+ FIG00003788 55 16 57 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_19778_1_424_- FIG00000822 94 15 94 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_19778_426_923_- FIG00000832 109 18 109 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_unique_19793_1_438_+ FIG00005237 22 6 24 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_19793_955_1980_- FIG00002944 88 21 89 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_unique_19805_1_165_+ FIG00002823 5 2 6 L-proline glycine betaine binding ABC transporter protein ProX (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_19819_754_1116_+ FIG00000621 11 5 12 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_19827_289_1023_+ FIG00108342 107 19 109 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_19834_343_774_- FIG00000402 97 15 97 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_19841_501_932_- FIG00000402 3 4 6 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_19861_896_1024_+ FIG00076542 22 3 22 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_19890_1805_2070_+ FIG00002328 5 2 8 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_19932_851_1987_- FIG00132839 237 37 239 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_19957_1_365_- FIG01292786 70 13 71 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_19962_951_1211_- FIG00022300 43 7 44 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_19978_1646_1972_- FIG00000477 41 8 42 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_20089_1881_2057_- FIG00138171 19 4 20 Queuosine biosynthesis QueD, PTPS-I Zinc regulated enzymes 1 T2D_unique_20095_1_1049_+ FIG00008230 8 6 11 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_20111_1_831_+ FIG00000056 42 12 46 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_20152_1057_1587_- FIG00139238 42 12 44 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_20154_1050_1334_+ FIG00000017 76 11 76 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_20187_1401_2051_+ FIG00000280 37 8 39 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_20215_434_1006_+ FIG00019652 40 10 41 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_20215_1201_1770_+ FIG00133569 52 11 54 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_20215_1793_2026_+ FIG00133325 10 2 11 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_20226_862_1458_- FIG00055715 98 17 100 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_20229_1536_2018_+ FIG00000388 5 2 6 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_20242_689_943_- FIG00006932 58 9 58 Capsular polysaccharide synthesis enzyme CpsC, polysaccharide export Exopolysaccharide Biosynthesis 1.0 T2D_unique_20247_886_1878_- FIG00000782 95 20 99 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_20253_1_434_- FIG00024401 6 2 8 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_20315_953_1237_- FIG00001676 6 2 8 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_20327_1_630_+ FIG00003299 22 6 25 L-arabinose-binding periplasmic protein precursor AraF (TC 3.A.1.2.2) L-Arabinose utilization 1 T2D_unique_20333_1_262_+ FIG00024546 24 5 25 Phosphonoacetaldehyde hydrolase (EC 3.11.1.1) Phosphonate metabolism 1 T2D_unique_20360_1_413_+ FIG00000235 17 6 19 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_20403_1_1025_+ FIG00451095 9 4 11 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_20410_1_214_+ FIG00132630 6 2 7 Ferric uptake regulation protein FUR Oxidative stress 1.2 T2D_unique_20441_237_968_- FIG00006463 195 28 195 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_20441_983_1186_- FIG00006463 41 7 42 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_20458_1331_2036_- FIG00437351 20 7 22 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_unique_20465_1846_2035_+ FIG00000323 38 6 39 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_20466_1762_1998_+ FIG00002049 49 7 49 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_20470_1_348_- FIG00004655 9 3 12 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_20489_1_1068_+ FIG00001548 97 21 98 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_20500_479_1105_+ FIG00561498 113 16 114 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_20520_1_254_- FIG01260980 10 3 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_20543_1691_1969_- FIG00000504 11 2 13 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_20573_1_192_- FIG00000477 14 3 15 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_20576_61_300_- FIG00000268 32 6 33 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_20594_94_786_- FIG00000897 77 13 79 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_20600_669_1106_+ FIG00001643 16 6 18 Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_20636_1_536_- FIG00025086 106 18 107 Xanthine permease Purine Utilization 1 T2D_unique_20641_133_879_+ FIG00007086 86 19 89 Substrate-specific component CbiM of cobalt ECF transporter ECF class transporters 345678 T2D_unique_20641_1216_2025_+ FIG00041137 54 12 55 Transmembrane component CbiQ of energizing module of cobalt ECF transporter ECF class transporters 345678 T2D_unique_20652_1072_1323_+ FIG00018699 21 6 22 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_20691_1073_1798_+ FIG00001166 13 4 14 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_20834_939_1223_- FIG00000741 7 4 9 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_unique_20845_1815_2009_+ FIG00010600 3 2 6 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_20881_1405_2010_+ FIG00000350 65 14 66 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_20897_1078_1326_+ FIG00000494 19 4 21 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_20914_1646_2008_+ FIG00048580 87 13 87 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_20917_1_260_- FIG00000065 57 10 57 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_20917_848_1078_+ FIG00003845 26 5 27 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_20934_1_367_- FIG00000355 16 5 17 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_20945_1117_1263_+ FIG00000601 12 3 13 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_20969_1_834_+ FIG00076542 46 12 48 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_20970_16_927_- FIG00009265 42 11 45 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) Selenocysteine metabolism 1.1 T2D_unique_20970_966_1439_- FIG00009265 6 2 7 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) Selenocysteine metabolism 1.1 T2D_unique_20972_1_459_+ FIG01955902 3 2 5 Rubredoxin Rubrerythrin 2 T2D_unique_20972_1334_1609_+ FIG00001067 30 7 31 Rubrerythrin Oxidative stress 1.2 T2D_unique_20985_636_1103_+ FIG00001385 4 3 6 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_20985_1163_1315_+ FIG00001385 4 2 5 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_21010_1_685_+ FIG00132801 143 23 143 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_21010_770_961_- FIG00093180 38 7 38 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_21010_985_1782_- FIG00093180 228 32 228 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_21060_1_1023_+ FIG01117646 211 36 212 Uncharacterized iron compound ABC uptake transporter, permease protein Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_21073_355_1092_+ FIG00000210 74 15 75 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_21076_1492_2000_- FIG00000121 32 9 34 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_21077_830_988_- FIG00012067 38 6 38 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_21077_994_1416_- FIG00012067 90 15 91 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_21116_1_462_- FIG00018865 6 2 7 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_21173_1497_1995_+ FIG00001604 129 19 129 Ornithine decarboxylase (EC 4.1.1.17) Polyamine Metabolism 2 T2D_unique_21179_1563_1995_- FIG00000367 83 14 84 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_21193_1066_1623_- FIG00000269 137 20 138 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_21195_1_545_+ FIG00047056 20 6 22 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_21197_628_1026_+ FIG00023946 102 15 102 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_21201_1140_1487_+ FIG00001547 29 7 30 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_21202_970_1994_- FIG00023369 200 36 202 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_21210_371_1087_+ FIG00000084 149 22 150 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_21231_1160_1992_+ FIG00028694 11 6 17 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_21247_1_1129_+ FIG01260980 265 39 266 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_21261_1794_1990_+ FIG00000085 9 2 10 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_21283_1_292_- FIG00001062 16 4 18 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_unique_21311_1454_1987_+ FIG00023943 37 8 38 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_21335_1_371_- FIG00000578 19 6 21 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_21335_400_804_+ FIG00010134 72 13 72 Methionine transporter MetT Methionine Degradation 3 T2D_unique_21343_1_368_- FIG00000223 66 12 67 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_21367_1_399_+ FIG00000494 37 9 38 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_21379_1_643_+ FIG00000154 25 5 28 LSU ribosomal protein L17p Ribosome LSU bacterial 9 T2D_unique_21406_1_624_+ FIG00007328 146 22 147 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_21410_1092_1619_+ FIG00000317 146 21 146 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_21415_564_875_- FIG00561498 15 4 16 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_21436_1109_1285_+ FIG00139238 31 5 31 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_21466_1_659_+ FIG00006167 38 9 40 Clostridial MutS2-related protein DNA repair, bacterial MutL-MutS system 1 T2D_unique_21482_1490_1976_+ FIG00132976 46 9 48 Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33) Acetoin, butanediol metabolism 5 T2D_unique_21515_1026_1975_+ FIG00010661 273 37 273 Alpha-L-Rha alpha-1,2-L-rhamnosyltransferase/alpha-L-Rha alpha-1,3-L- rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_21575_1_190_+ FIG00001449 48 7 48 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_unique_21669_1097_1822_+ FIG00000494 21 7 26 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_21734_955_1398_- FIG00000017 18 5 19 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_21734_1450_1963_- FIG00080955 23 5 24 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_21764_143_391_+ FIG00001611 64 9 64 Protein of unknown function DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_21849_1_481_+ FIG00019251 130 19 130 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_21850_1_944_- FIG00000838 263 37 263 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_21850_1409_1957_+ FIG00001105 4 2 5 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_unique_21910_446_1195_+ FIG00002561 76 13 77 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_22014_1395_1949_- FIG00002914 45 13 48 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_22069_1_788_- FIG00049915 115 24 117 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_22104_1_393_+ FIG01583289 49 8 50 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_22105_1_570_+ FIG00719736 30 9 31 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_22110_1_650_- FIG00000145 159 25 159 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_22144_1223_1741_- FIG00000184 137 20 137 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_22153_1_513_- FIG00067248 72 14 73 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_22176_1_663_+ FIG00058830 82 15 83 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_22192_950_1246_- FIG00001175 16 3 17 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_22195_1110_1448_+ FIG00001579 80 13 80 D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13) D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_22195_1517_1938_+ FIG00001531 113 16 113 D-alanyl transfer protein DltB D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_22196_1_488_+ FIG00023946 7 2 9 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_22213_1424_1937_- FIG00000095 20 7 21 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_22221_976_1275_- FIG01260980 5 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_22239_1268_1576_- FIG00003655 69 12 69 PTS system, lactose-specific IIA component (EC 2.7.1.69) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_22263_1_184_+ FIG00000098 30 5 30 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_22288_293_745_+ FIG00007079 14 4 15 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_22350_1612_1930_- FIG01304224 4 2 6 Large exoproteins involved in heme utilization or adhesion CBSS-316057.3.peg.3521 1 T2D_unique_22388_1797_1928_+ FIG00000822 22 4 22 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_22390_1_1147_- FIG00001269 122 26 123 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_22423_1_293_- FIG00000221 45 10 46 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_22431_959_1678_- FIG00000480 170 26 172 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_22443_1_144_+ FIG00085740 22 4 23 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_22443_1076_1249_+ FIG00022300 36 6 37 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_22494_1049_1923_+ FIG00133034 62 13 65 Excinuclease ABC subunit A paralog of unknown function DNA repair, UvrABC system 1 T2D_unique_22501_509_1060_+ FIG00000388 68 11 69 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_22523_1447_1776_+ FIG00002224 85 13 85 protein from nitrogen regulatory protein P-II (GLNB) family, ortholog YAAQ B. subtilis CBSS-393133.3.peg.2787 1 T2D_unique_22532_1576_1921_+ FIG00002239 16 4 17 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_22544_1659_1921_+ FIG00003841 4 2 5 Putative sugar ABC transport system, periplasmic binding protein YtfQ precursor Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_22567_1_288_- FIG00046195 73 11 74 Type III restriction-modification system DNA endonuclease res (EC 3.1.21.5) Restriction-Modification System 3.x T2D_unique_22678_1721_1914_+ FIG00001253 13 4 14 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_22681_611_949_- FIG00000985 32 6 33 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_22697_1073_1372_+ FIG01260980 11 3 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_22720_1090_1912_+ FIG00001366 54 17 101 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_22755_491_1090_+ FIG00000243 12 5 14 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_22774_1_270_+ FIG00000370 40 7 41 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_22777_1769_1909_- FIG00022300 20 4 20 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_22799_328_936_+ FIG00000298 102 18 103 GTP-binding protein EngB Universal GTPases 2 T2D_unique_22800_1286_1591_- FIG00138171 80 11 80 Queuosine biosynthesis QueD, PTPS-I Zinc regulated enzymes 1 T2D_unique_22888_983_1267_- FIG00002049 43 8 43 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_22888_1299_1904_- FIG00006691 99 20 99 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_22902_1668_1903_+ FIG00075702 14 4 15 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_22911_763_972_- FIG00018396 46 7 47 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_22915_1051_1455_+ FIG01260980 48 8 49 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_22950_1_513_+ FIG00005705 12 5 14 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_unique_22950_1061_1900_+ FIG00006997 53 12 55 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_22978_1057_1899_- FIG00117785 111 19 114 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_unique_23014_1295_1897_- FIG01290653 15 5 19 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_23028_1_262_+ FIG00000449 37 6 38 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_23074_1014_1751_+ FIG00001469 8 5 12 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_23087_1465_1893_+ FIG00000118 12 4 14 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_23102_1313_1771_+ FIG00012358 102 17 104 Negative transcriptional regulator-copper transport operon Copper homeostasis 12 T2D_unique_23108_1_965_- FIG01303805 124 21 124 Maltodextrin phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_23108_980_1459_- FIG01303805 68 12 68 Maltodextrin phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_23108_1488_1892_- FIG00028461 111 16 111 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_23128_1102_1891_- FIG00000118 7 2 9 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_23163_1_205_- FIG00004788 43 7 43 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_23164_1_784_- FIG00028694 32 10 34 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_23193_315_824_- FIG00000897 54 11 55 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_23212_318_1001_+ FIG00001452 14 7 17 Transcriptional repressor of the fructose operon, DeoR family Fructose utilization 1 T2D_unique_23225_1_1024_+ FIG00001882 269 38 270 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_23225_1060_1236_+ FIG00001882 29 5 29 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_23241_393_1166_+ FIG00000402 17 7 19 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_23276_1_637_+ FIG00024851 32 10 35 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_23296_1_567_+ FIG00000140 91 16 92 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_23296_1740_1883_- FIG00000348 22 4 23 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_unique_23321_1168_1882_- FIG00006551 146 27 146 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_23333_31_384_+ FIG00135315 19 7 21 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_23352_1_404_+ FIG00000440 20 7 22 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_unique_23390_1476_1879_- FIG00000858 23 6 25 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_unique_23443_643_1086_+ FIG00136692 77 13 78 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_23454_876_1876_- FIG00016836 31 6 36 Transcription termination protein NusB Transcription factors bacterial 1 T2D_unique_23458_1_478_- FIG00075970 11 5 12 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_23524_199_1038_+ FIG00229386 30 6 32 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_23532_1_248_+ FIG00002239 10 3 11 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_23568_1_647_- FIG00022899 46 13 48 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_23568_1024_1870_+ FIG00001311 76 16 79 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_unique_23599_262_504_- FIG00002328 65 9 65 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_23619_850_1002_+ FIG00000555 30 5 31 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_23630_1_864_- FIG00133034 189 31 191 Excinuclease ABC subunit A paralog of unknown function DNA repair, UvrABC system 1 T2D_unique_23633_1_402_+ FIG00074916 96 15 96 Acetolactate synthase, catabolic (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_23633_416_1042_+ FIG00001396 154 23 154 Alpha-acetolactate decarboxylase (EC 4.1.1.5) Acetoin, butanediol metabolism 5 T2D_unique_23636_1_591_- FIG00043476 37 7 40 preQ1-regulated inosine-uridine nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_23651_1697_1866_+ FIG00012037 8 2 10 heterodisulfide reductase, iron-sulfur binding subunit, putative Anaerobic respiratory reductases 3 T2D_unique_23671_1_352_- FIG01266244 23 6 25 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_23760_1_1019_+ FIG00000539 86 20 88 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_23770_711_1040_+ FIG00000134 6 3 8 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_23792_1523_1859_+ FIG00023019 5 3 6 Carbonic anhydrase (EC 4.2.1.1) Zinc regulated enzymes 1 T2D_unique_23821_1_269_- FIG00000070 5 3 10 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_23849_1328_1855_- FIG00135025 37 9 39 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_23852_1_163_+ FIG00133774 7 2 7 2-ketoaldonate reductase, broad specificity (EC 1.1.1.215) (EC 1.1.1.-) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_23855_1_559_- FIG01260980 16 5 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_23880_1_371_+ FIG00561498 14 3 15 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_23880_503_1225_+ FIG00561498 4 2 7 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_23887_1068_1478_+ FIG00000017 36 8 37 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_23898_1_414_+ FIG00018396 96 16 96 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_23955_982_1851_- FIG01260980 245 34 246 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_23967_239_910_- FIG00044622 55 12 56 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_23985_1345_1850_+ FIG01010650 3 3 4 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_24015_456_1022_+ FIG00000624 46 10 47 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_24030_79_873_+ FIG00016888 11 4 12 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_24054_709_885_- FIG00022300 38 6 38 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_24071_1188_1760_- FIG00000673 162 23 162 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_unique_24113_131_850_- FIG00005243 92 18 93 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_24126_653_796_- FIG00000040 4 2 6 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_24183_1035_1325_+ FIG00005992 23 6 25 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_24255_761_1057_+ FIG00000539 28 6 29 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_24300_1344_1834_- FIG00006463 41 11 44 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_24318_231_785_- FIG00038343 8 3 9 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_24341_1100_1833_+ FIG00000156 160 25 161 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_24353_179_1129_+ FIG00001548 8 3 10 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_24439_1040_1618_+ FIG00005587 7 3 9 Transcriptional regulator of rhamnose utilization, AraC family L-rhamnose utilization 1 T2D_unique_24446_688_1035_+ FIG00000985 5 4 6 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_24451_279_725_- FIG00000812 25 5 26 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_24490_948_1427_+ FIG00012067 111 17 112 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_24490_1458_1826_- FIG00000402 102 15 102 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_24541_806_1824_- FIG00035175 5 4 8 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_24556_1_209_- FIG00000151 58 8 58 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_24566_104_907_- FIG00000504 31 7 37 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_24691_1_369_+ FIG00132548 6 3 8 Thiol peroxidase, Bcp-type (EC 1.11.1.15) CBSS-316057.3.peg.3521 1 T2D_unique_24694_250_504_+ FIG00001824 30 5 31 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_24745_1069_1815_+ FIG00018699 4 3 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_24762_893_1090_+ FIG00038461 23 4 25 Putative deoxyribonuclease YjjV Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_24762_1351_1572_+ FIG00038461 59 8 59 Putative deoxyribonuclease YjjV Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_24797_1464_1812_- FIG00001385 7 4 8 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_24813_1_512_- FIG00138538 59 12 72 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_24829_1449_1595_- FIG00077620 8 3 9 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_24840_1_129_+ FIG00002799 12 3 13 Phosphoheptose isomerase 1 (EC 5.3.1.-) Capsular heptose biosynthesis 1 T2D_unique_24840_1225_1749_+ FIG00004229 18 6 20 Heptaprenyl diphosphate synthase component I (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_24856_654_950_- FIG00000621 14 4 16 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_24891_1_806_- FIG00000056 86 22 87 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_24891_974_1192_- FIG00009229 12 3 13 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_24898_701_1093_+ FIG00001145 27 5 28 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_24898_1165_1410_+ FIG00001145 23 5 24 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_24907_1026_1295_+ FIG00000025 55 9 55 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_24952_1_938_- FIG00073301 78 18 81 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_24952_965_1384_- FIG00073301 20 6 21 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_25056_1_554_- FIG00093180 18 5 20 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_25239_617_919_- FIG00146678 84 12 84 Cytochrome c-type biogenesis protein CcdA homolog, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_25239_988_1776_- FIG00146678 83 12 86 Cytochrome c-type biogenesis protein CcdA homolog, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_25246_1_1022_+ FIG00001695 90 22 92 D-serine dehydratase (EC 4.3.1.18) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_25246_1052_1321_+ FIG00001695 8 3 9 D-serine dehydratase (EC 4.3.1.18) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_25252_1_654_- FIG01306479 3 2 4 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_25258_1_1031_+ FIG00004078 42 14 44 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_25266_658_1032_+ FIG00020185 79 12 79 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_25286_362_628_- FIG00132994 39 6 40 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_25286_650_886_- FIG00001409 6 3 7 5-deoxy-glucuronate isomerase (EC 5.3.1.-) Inositol catabolism 5.x T2D_unique_25312_1_443_- FIG00007960 39 11 40 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_25315_981_1790_- FIG01260980 27 10 30 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_25329_1568_1790_+ FIG00000301 23 6 34 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_25353_1481_1789_+ FIG00000223 53 10 55 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_25365_1_468_- FIG00000847 122 18 122 Allophanate hydrolase 2 subunit 1 (EC 3.5.1.54) EC699-706 1 T2D_unique_25403_1194_1786_+ FIG00120441 54 11 56 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_25419_1_396_- FIG00000076 59 10 62 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_25433_1381_1785_+ FIG00001452 78 14 78 Transcriptional repressor of the fructose operon, DeoR family Fructose utilization 1 T2D_unique_25436_1_450_+ FIG00000025 53 12 55 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_25436_470_1138_+ FIG00034392 16 4 17 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_25437_1166_1785_+ FIG00037431 33 11 34 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_25455_1_848_+ FIG00038920 48 15 50 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_25455_1055_1645_+ FIG00001119 47 12 49 Glycerol-3-phosphate regulon repressor, DeoR family Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_25469_1_267_- FIG01280345 7 3 8 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_25491_1284_1783_+ FIG00066504 128 19 129 Glucarate dehydratase (EC 4.2.1.40) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_25496_958_1236_- FIG00000337 15 5 17 Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_unique_25498_1011_1783_+ FIG00000118 114 20 116 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_25518_381_1013_+ FIG00001819 51 12 52 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_25542_1_833_- FIG00000990 223 33 223 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_25542_965_1123_- FIG00000990 30 5 31 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_25569_1_140_- FIG00007941 26 4 26 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_25581_403_1026_+ FIG00066643 65 13 67 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_25596_537_1022_+ FIG00138298 121 18 121 Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF L-rhamnose utilization 1 T2D_unique_25669_589_1062_+ FIG00000013 25 4 28 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_25685_66_593_+ FIG00044622 131 20 131 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_25751_1_266_- FIG00143531 26 8 28 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_unique_25765_1146_1771_+ FIG00000156 78 15 79 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_25766_1547_1771_- FIG00000001 19 5 21 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_25772_944_1738_- FIG00000402 74 15 75 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_25777_1095_1771_- FIG00000494 45 9 48 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_25786_1311_1771_- FIG00000522 106 18 106 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_25824_1_301_+ FIG00001469 7 4 9 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_25842_538_1023_+ FIG00000038 67 15 68 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_25893_1186_1659_+ FIG00023946 25 7 27 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_25911_1_249_+ FIG00000395 73 10 73 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_25920_1_435_- FIG00007514 12 5 14 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_25936_1160_1765_+ FIG00006167 18 5 22 Clostridial MutS2-related protein DNA repair, bacterial MutL-MutS system 1 T2D_unique_25961_1_1017_+ FIG00007957 108 21 110 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_25972_1_318_- FIG00130344 85 12 85 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_25975_1191_1763_+ FIG00000308 13 4 15 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_26049_1537_1760_+ FIG00145793 55 8 56 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase (EC 6.3.2.7) Peptidoglycan biosynthesis--gjo 1 T2D_unique_26070_1341_1760_- FIG00001145 36 9 37 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_26091_1392_1759_+ FIG00011468 18 8 29 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_26103_1316_1758_- FIG00001636 4 2 6 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_unique_26108_1121_1735_+ FIG00013525 12 5 16 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_unique_26121_1517_1758_- FIG00003555 4 2 5 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_26133_549_1034_+ FIG00009156 104 16 104 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_26133_1223_1757_+ FIG00008370 136 20 137 Creatinine amidohydrolase (EC 3.5.2.10) Creatine and Creatinine Degradation 4.0 T2D_unique_26144_1514_1757_- FIG00000139 42 9 43 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_26170_1_393_- FIG01307086 6 3 7 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_26239_1_445_- FIG00009149 7 6 31 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_26265_1007_1752_+ FIG00041038 205 29 205 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_26278_111_839_- FIG00019652 209 29 209 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_26336_1339_1749_- FIG00000584 5 3 6 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_26339_969_1358_- FIG00042267 62 11 63 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_26348_1_133_+ FIG00001133 33 5 33 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_unique_26348_162_428_+ FIG00001489 58 10 58 ribosomal protein L7Ae family protein Transcription factors bacterial 1 T2D_unique_26348_449_1012_+ FIG00000102 133 20 133 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_26406_1593_1746_+ FIG00011468 8 2 9 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_26416_349_939_- FIG00000681 6 2 7 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_unique_26439_733_885_- FIG00000660 18 4 18 Cystathionine gamma-synthase (EC 2.5.1.48) Methionine Biosynthesis 8 T2D_unique_26449_1_357_+ FIG00003955 98 14 98 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_26449_372_869_+ FIG00001960 136 19 136 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_26449_1090_1674_+ FIG00133325 135 22 136 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_26463_750_1439_- FIG00001401 27 10 28 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_26467_1_1114_+ FIG00000645 113 22 115 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_26483_364_903_- FIG00000028 10 3 12 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_26484_1_493_+ FIG00010524 44 9 45 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_26523_667_1125_+ FIG00004589 7 3 10 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_26556_994_1740_- FIG00003086 6 2 7 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_26565_1128_1740_+ FIG00000263 40 10 43 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_26566_1_642_- FIG00002541 162 23 163 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_26571_957_1740_- FIG00000422 51 11 53 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_26602_1403_1738_- FIG00000309 12 4 14 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_26621_843_1061_+ FIG00001577 5 2 6 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_26647_1056_1736_- FIG00000036 138 24 139 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_26714_1_990_- FIG00017190 54 16 59 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_26729_1178_1734_- FIG00475203 44 10 47 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_26741_974_1734_- FIG00005727 12 5 13 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_26779_589_1149_+ FIG00004220 41 9 43 Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5) Protein degradation 1 T2D_unique_26846_1335_1730_+ FIG00000892 7 3 9 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_26874_45_425_+ FIG00062547 101 15 101 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_26878_1_775_- FIG00009775 37 8 40 Glycosyl transferase, group 1 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_26883_1271_1728_- FIG00000456 54 10 55 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_26886_1_1040_+ FIG00000711 268 39 268 Phosphoenolpyruvate carboxylase (EC 4.1.1.31) Serine-glyoxylate cycle 1 T2D_unique_26886_1061_1728_+ FIG00000711 169 26 170 Phosphoenolpyruvate carboxylase (EC 4.1.1.31) Serine-glyoxylate cycle 1 T2D_unique_26895_1017_1728_+ FIG00005587 8 3 11 Transcriptional regulator of rhamnose utilization, AraC family L-rhamnose utilization 1 T2D_unique_26917_111_875_- FIG00002385 53 11 56 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_26945_1_152_+ FIG00132967 16 3 17 Iron(III) dicitrate transport ATP-binding protein FecE (TC 3.A.1.14.1) Flavohaemoglobin 1 T2D_unique_26945_975_1286_- FIG00034200 50 8 51 Arsenic resistance protein ArsH Arsenic resistance 1 T2D_unique_26971_1165_1725_- FIG00000155 72 13 73 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_27015_1596_1723_- FIG00000260 3 2 5 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_27022_914_1294_- FIG00000244 22 5 23 Ketol-acid reductoisomerase (EC 1.1.1.86) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_27022_1326_1723_- FIG00000433 12 5 13 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_27023_129_803_- FIG00003530 55 13 58 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_27052_1_332_- FIG00058830 66 11 66 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_27109_1182_1720_- FIG00077620 20 7 22 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_27164_1_671_+ FIG00001608 155 24 156 Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_27178_1379_1717_- FIG00000402 16 5 18 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_27208_1_144_+ FIG00077620 31 5 31 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_27220_607_1002_+ FIG00004788 24 6 25 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_27227_1209_1716_- FIG00059211 144 20 144 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_27295_1193_1713_+ FIG00000242 40 9 52 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_27296_1_209_- FIG00035701 25 4 26 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_27324_1388_1712_+ FIG01116805 85 12 85 Inducible Fructanase (EC 3.2.1.80), FruB Fructose and Mannose Inducible PTS 2 T2D_unique_27353_1530_1711_+ FIG00001862 8 2 9 L-rhamnose mutarotase L-rhamnose utilization 1 T2D_unique_27364_982_1548_- FIG00000025 73 13 74 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_27378_1_336_+ FIG00000672 32 7 33 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_27399_1433_1588_- FIG01955902 16 4 16 Rubredoxin Rubrerythrin 2 T2D_unique_27420_1498_1708_+ FIG00145793 50 8 50 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase (EC 6.3.2.7) Peptidoglycan biosynthesis--gjo 1 T2D_unique_27426_1100_1612_+ FIG00001882 51 14 52 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_27555_924_1532_- FIG00129616 45 13 46 GTP-binding protein EngA Universal GTPases 2 T2D_unique_27560_1340_1702_+ FIG00132787 70 13 70 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_27581_1_542_- FIG00031969 51 11 52 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_27582_1074_1667_+ FIG00010738 35 9 36 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_27587_75_1025_+ FIG00001469 158 31 160 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_27589_93_314_+ FIG00001385 4 2 13 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_27597_1_174_+ FIG00134060 40 6 40 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_27597_175_747_+ FIG00001505 137 22 137 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_27597_763_1005_+ FIG00133292 41 8 41 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_27597_1020_1553_+ FIG00133292 149 20 150 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_27608_1059_1277_+ FIG00001712 6 3 9 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_27611_1_240_- FIG00000242 8 2 9 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_27638_611_1006_+ FIG00007960 29 6 30 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_27664_1_599_- FIG01307086 123 19 124 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_27668_860_1402_- FIG00027222 29 9 30 GDP-L-fucose synthetase (EC 1.1.1.271) Capsular heptose biosynthesis 1 T2D_unique_27679_188_595_- FIG00000479 28 6 30 Zinc uptake regulation protein ZUR Zinc regulated enzymes 1 T2D_unique_27705_961_1696_- FIG00000309 174 26 177 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_27706_1_299_+ FIG00042616 14 3 15 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_27769_959_1694_- FIG00000402 25 9 26 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_27778_572_988_- FIG00037273 46 9 48 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_unique_27784_1538_1693_+ FIG00000175 5 2 6 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_27823_920_1692_- FIG01260980 152 25 152 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_27828_1_512_+ FIG00000440 52 10 53 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_unique_27872_1_1010_+ FIG00006463 3 4 5 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_27888_1_977_+ FIG00623809 170 28 173 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_27889_1446_1690_+ FIG00000464 45 8 46 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_27899_1_156_+ FIG00000538 21 4 22 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_unique_27913_498_1088_+ FIG00000402 25 6 26 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_27944_1_217_- FIG00126843 9 3 10 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_27993_948_1532_- FIG00000084 136 21 138 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_27993_1553_1686_- FIG00001168 26 5 26 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_28054_907_1041_+ FIG00000156 6 2 7 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_28074_1241_1683_- FIG00000087 26 5 28 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_28078_347_892_- FIG00001011 133 20 134 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_28078_940_1173_- FIG00001011 44 6 44 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_28091_1_850_- FIG00000962 242 34 242 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_28133_1489_1681_+ FIG00000411 46 6 46 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_28134_1050_1589_+ FIG00007025 15 5 19 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_28140_1212_1681_+ FIG00063189 6 2 8 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_28157_1457_1680_- FIG00000392 46 7 47 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_28188_1_612_- FIG00003086 27 7 28 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_28210_1347_1678_- FIG01271998 61 10 61 Possible hypoxanthine oxidase XdhD (EC 1.-.-.-) Purine conversions 4.1118100 T2D_unique_28226_699_1022_+ FIG00028694 61 11 62 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_28230_1370_1677_+ FIG00000121 54 9 55 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_28231_597_1001_+ FIG00000441 49 10 50 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_28244_1_441_+ FIG00014013 8 5 9 Spore cortex-lytic enzyme CwlJ Spore germination 1 T2D_unique_28248_1453_1676_+ FIG00006165 6 2 7 Uracil-DNA glycosylase, family 4 Uracil-DNA glycosylase 1 T2D_unique_28289_1165_1675_+ FIG01260980 28 10 30 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_28296_1_333_+ FIG00067681 29 7 30 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_28296_490_939_+ FIG00000101 27 7 29 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_28299_1_1005_+ FIG00000356 255 39 256 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_28303_1190_1675_+ FIG00000084 11 3 15 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_28318_1051_1560_+ FIG00543846 10 2 11 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_28321_547_990_- FIG00000333 110 17 110 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_28330_664_1158_+ FIG00003460 75 12 76 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_28405_1_513_+ FIG00000130 134 20 134 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_28405_516_1283_+ FIG00000111 117 19 118 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_28408_1_1127_+ FIG00002541 288 40 289 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_28412_1125_1671_- FIG01260980 125 20 126 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_28447_1_656_- FIG00000822 151 24 151 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_28458_1_816_- FIG00026595 182 29 183 ABC transporter membrane-spanning permease, Pep export, Vex3 Streptococcus pneumoniae Vancomycin Tolerance Locus 3 T2D_unique_28470_1_584_- FIG00000245 97 18 99 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_28480_1165_1669_- FIG00000206 38 10 40 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_28497_993_1295_- FIG00007960 83 11 83 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_28522_161_901_+ FIG00052300 12 5 14 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_28522_1213_1401_+ FIG01280345 9 4 10 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_28556_1_182_- FIG00138413 13 5 14 Fructose-1,6-bisphosphatase, GlpX type (EC 3.1.3.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_28561_1_352_+ FIG00006463 93 13 93 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_28561_1378_1667_+ FIG01959487 44 7 44 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK Dihydroxyacetone kinases 3 T2D_unique_28587_1_514_- FIG00011537 6 2 7 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_28609_1060_1665_- FIG00011114 139 22 139 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_28658_1491_1664_- FIG00023946 16 4 17 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_28669_1291_1663_- FIG01336391 58 10 59 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Rhamnose containing glycans 4.1 T2D_unique_28696_1088_1663_- FIG00000911 148 22 148 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_28718_960_1662_- FIG00006868 34 8 36 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_28764_53_574_- FIG00000155 75 15 76 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_28764_993_1502_- FIG00001577 58 11 59 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_28777_1137_1660_+ FIG00021289 31 10 32 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_28785_1084_1660_+ FIG00006151 61 13 62 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_28791_1061_1240_+ FIG00000413 25 5 26 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_28842_279_731_- FIG00000205 107 17 107 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_28843_928_1122_- FIG00004528 17 4 18 Di-/tripeptide transporter Proton-dependent Peptide Transporters 1 T2D_unique_28902_121_762_+ FIG00001237 171 25 171 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_28946_1344_1655_- FIG00005111 26 7 27 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_unique_28970_11_934_- FIG00000494 17 9 19 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_28972_1108_1422_+ FIG00001862 28 7 29 L-rhamnose mutarotase L-rhamnose utilization 1 T2D_unique_28981_1_430_+ FIG00001642 47 8 48 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_28984_471_965_- FIG00000280 122 18 122 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_28984_980_1653_- FIG00000280 133 20 134 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_28985_951_1653_- FIG00130900 37 10 38 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_unique_28987_1186_1653_- FIG00001198 7 2 10 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_28994_951_1250_- FIG00002449 68 10 69 Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48) Exopolysaccharide Biosynthesis 1.0 T2D_unique_29008_382_606_- FIG00031250 43 8 44 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_29020_1_509_- FIG00135025 36 9 37 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_29092_1382_1649_+ FIG00001896 3 2 4 LSU ribosomal protein L25p Ribosome LSU bacterial 9 T2D_unique_29100_1300_1649_- FIG00000126 80 12 81 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_29202_24_629_- FIG00127025 136 21 136 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_29205_1082_1609_+ FIG00010876 90 16 91 Two-component sensor kinase YesM (EC 2.7.3.-) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_29228_1347_1645_+ FIG00000011 80 11 80 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_29246_1_338_+ FIG00000391 20 5 21 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_29251_1102_1293_+ FIG00095288 6 2 7 Cell wall endopeptidase, family M23/M37 Glutaredoxins 1 T2D_unique_29258_276_968_- FIG00009194 52 12 54 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_29258_983_1644_- FIG00009194 46 10 49 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_29271_977_1644_- FIG00067248 85 19 86 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_29289_368_1012_+ FIG00046929 82 16 84 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_29289_1045_1643_+ FIG00046929 98 17 99 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_29319_1_729_- FIG00064110 72 20 76 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_29338_1459_1642_- FIG00000793 5 2 6 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_29354_1_529_+ FIG00018035 129 19 129 Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter ECF class transporters 345678 T2D_unique_29354_624_1007_+ FIG00016685 101 15 101 Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter ECF class transporters 345678 T2D_unique_29370_1035_1641_+ FIG00000404 46 10 48 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_29401_976_1602_+ FIG00000001 3 3 5 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_29404_411_608_+ FIG00000741 13 4 14 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_unique_29434_1_372_- FIG00001106 79 14 80 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_29437_145_906_- FIG00018699 19 7 22 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_29452_373_714_+ FIG00000200 26 9 28 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_unique_29463_547_1008_+ FIG00003535 125 17 125 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_29463_1023_1367_+ FIG00003535 74 13 74 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_29527_1128_1636_+ FIG00002541 141 20 141 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_29597_1028_1495_+ FIG00083946 38 10 40 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_29634_1335_1632_- FIG00000118 47 9 48 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_29644_1_913_+ FIG00001548 263 37 263 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_29644_929_1632_- FIG00182617 175 25 176 Predicted alpha-L-rhamnosidase L-rhamnose utilization 1 T2D_unique_29645_1265_1632_+ FIG00000001 17 6 18 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_29646_733_1014_+ FIG00000081 6 3 8 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_29649_29_1003_+ FIG00000782 19 7 21 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_29702_1_981_- FIG00120441 66 16 107 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_29781_1437_1627_- FIG00000130 24 4 25 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_29782_329_757_+ FIG00004296 37 8 39 Amino acid-binding ACT Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_29893_1_509_+ FIG00011382 10 5 12 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_unique_29946_492_701_+ FIG00000624 28 5 29 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_29972_1_893_- FIG01260980 246 35 247 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_29972_992_1621_- FIG01260980 171 25 171 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_30033_1_426_+ FIG00001294 111 15 112 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_unique_30065_1089_1598_- FIG00002199 99 16 109 Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11) Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_30069_963_1199_- FIG00018865 14 4 15 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_30080_1049_1477_+ FIG00001474 113 17 113 Ribonuclease HIII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_30096_1_452_+ FIG00000303 109 17 110 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_30096_455_1060_+ FIG00000601 136 21 138 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_30102_1071_1617_+ FIG00000402 26 9 28 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_30109_1061_1510_+ FIG00000317 58 12 60 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_30176_1335_1493_- FIG01955902 31 6 31 Rubredoxin Rubrerythrin 2 T2D_unique_30184_615_956_- FIG00001547 10 4 11 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_30199_1_268_- FIG00000397 51 8 52 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_30204_1149_1352_+ FIG01260980 17 3 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_30250_1_315_+ FIG00000376 7 4 9 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_30286_1056_1611_+ FIG00000025 5 5 8 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_30301_1426_1611_- FIG00001388 37 6 37 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_unique_30311_1378_1610_- FIG00000377 18 4 19 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_30327_1001_1609_+ FIG00003086 8 5 10 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_30339_1265_1609_+ FIG00719736 7 4 8 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_30353_552_962_- FIG00001653 103 16 103 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_30353_965_1429_- FIG00001653 119 17 119 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_30366_1_501_- FIG00000401 95 17 97 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_30397_1090_1464_+ FIG00000404 15 6 27 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_30408_546_1088_- FIG00126843 31 7 33 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_30431_234_800_- FIG00000314 135 21 135 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_30451_1_1024_+ FIG00001824 57 13 59 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_30451_1051_1182_+ FIG00001824 13 3 14 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_30474_1111_1604_+ FIG00000116 5 2 6 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_30479_554_1042_+ FIG00000421 32 7 33 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_30479_1093_1404_+ FIG00000421 30 6 31 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_30507_1_490_+ FIG00093180 97 16 98 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_30529_1_363_- FIG00000184 19 6 20 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_30536_1080_1385_+ FIG00009682 18 4 21 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_30538_1_429_+ FIG00013638 49 13 75 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_30560_385_1164_+ FIG00000897 11 6 13 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_30649_44_970_- FIG00003212 35 11 37 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_30656_1235_1599_+ FIG00011468 9 3 11 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_30658_1333_1599_- FIG01266244 9 3 11 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_30668_957_1598_- FIG00000539 152 23 152 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_30682_1032_1448_+ FIG00012531 8 2 10 TRAP-type transport system, small permease component, predicted N-acetylneuraminate transporter Sialic Acid Metabolism 1.x T2D_unique_30683_1_394_- FIG00000112 99 16 99 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_30683_442_942_- FIG00080955 132 19 132 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_30683_963_1598_- FIG00080955 156 23 157 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_30691_1_262_+ FIG00000070 10 4 11 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_30704_1308_1597_+ FIG00000140 16 4 17 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_30705_466_1152_+ FIG01303154 15 5 17 Ubiquinone/menaquinone biosynthesis methyltransferase UbiE (EC 2.1.1.-) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_30732_1_486_+ FIG00000298 129 18 129 GTP-binding protein EngB Universal GTPases 2 T2D_unique_30737_1_527_+ FIG00000737 32 7 36 Two-component system response regulator QseB Orphan regulatory proteins 1 T2D_unique_30740_549_1148_+ FIG00004744 121 17 122 Rare lipoprotein A precursor Peptidoglycan Biosynthesis 1.9 T2D_unique_30771_1_185_- FIG01007502 17 4 18 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_30774_1_248_+ FIG00229216 12 4 14 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_30795_1_825_+ FIG00084105 15 11 31 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_30795_1021_1594_+ FIG00000069 11 5 12 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_30801_1_725_- FIG01260980 42 15 46 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_30825_587_1054_+ FIG00007339 12 4 14 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_30825_1060_1245_+ FIG00007339 9 3 10 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_30852_1_418_+ FIG00000101 84 13 85 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_30873_1_146_+ FIG01260980 17 4 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_30873_1375_1592_- FIG00000383 8 3 9 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_30886_946_1591_- FIG00049433 23 8 25 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_30910_983_1591_- FIG00001604 156 23 157 Ornithine decarboxylase (EC 4.1.1.17) Polyamine Metabolism 2 T2D_unique_30968_825_1052_+ FIG00077620 7 2 8 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_30991_978_1588_- FIG01304275 35 9 60 Ferrichrome transport ATP-binding protein FhuC (TC 3.A.1.14.3) Hemin transport system 1 T2D_unique_31004_1_582_+ FIG00561498 137 20 137 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_31006_840_1013_+ FIG00001280 16 4 17 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_31007_169_963_- FIG00001385 130 21 131 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_31020_230_961_- FIG00000822 12 4 14 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_31058_1_863_+ FIG00010600 16 4 25 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_31068_1_307_- FIG00007079 13 4 14 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_31120_725_934_- FIG01262685 51 8 51 Fructose-bisphosphate aldolase class I (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_31140_1226_1584_+ FIG00004169 43 8 43 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_31191_1_421_+ FIG00016132 6 2 7 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_unique_31207_1165_1582_- FIG00002273 51 8 53 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_31218_1145_1581_+ FIG00041038 4 4 6 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_31229_1075_1581_+ FIG00000032 47 10 49 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_31247_918_1581_- FIG00138004 92 16 93 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_31267_1_151_+ FIG00133143 5 3 6 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) Cysteine Biosynthesis 2.17 T2D_unique_31271_1_418_+ FIG00028461 29 7 30 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_31371_1063_1341_+ FIG00007694 8 3 9 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_31398_1_174_+ FIG00028203 19 4 22 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_31402_1444_1576_+ FIG00000279 10 2 11 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_31442_695_1075_+ FIG00000532 42 9 43 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_31443_1315_1575_+ FIG00001469 4 3 5 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_31447_283_1014_+ FIG00000234 119 23 120 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_31452_1_492_+ FIG00001882 129 19 129 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_31452_512_1003_+ FIG00001011 136 19 136 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_31452_1165_1551_+ FIG00001011 35 6 36 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_31479_1_1017_+ FIG00025216 75 19 76 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_31479_1089_1574_+ FIG00025216 3 2 4 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_31481_1083_1445_+ FIG00006165 18 4 19 Uracil-DNA glycosylase, family 4 Uracil-DNA glycosylase 1 T2D_unique_31524_953_1573_- FIG00001269 60 11 61 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_31683_1161_1567_+ FIG00000531 45 9 47 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_31718_1_911_- FIG00001029 252 37 252 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_31742_1000_1566_- FIG00001020 148 21 148 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_31781_13_432_- FIG00081563 12 4 15 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_31792_375_1019_+ FIG00000404 157 24 158 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_31851_1405_1562_+ FIG00109688 16 4 17 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_31892_1213_1561_- FIG00059124 27 6 28 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_31908_1274_1560_+ FIG00521220 73 11 73 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_31911_523_714_- FIG00000394 18 5 19 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_31926_190_1071_+ FIG00000146 207 30 207 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_31929_1033_1356_+ FIG00000402 79 12 79 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_32008_1101_1557_+ FIG00002689 100 15 101 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_32013_1_1063_- FIG00000080 177 31 179 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_32053_584_1003_+ FIG00018369 112 16 112 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_32072_1_668_- FIG00002470 37 8 39 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_32104_1363_1555_+ FIG00000414 23 5 24 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_32161_52_252_- FIG00004100 47 7 47 Cold shock protein CspA Cold shock, CspA family of proteins 1 T2D_unique_32192_956_1552_- FIG00007957 27 8 33 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_32202_1074_1552_+ FIG00007957 29 8 31 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_32236_780_1037_+ FIG00010600 46 8 47 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_32314_299_598_+ FIG00001676 9 3 11 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_32331_1_524_- FIG00006691 23 8 24 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_32331_551_934_- FIG01954097 39 9 40 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_32341_998_1471_- FIG00455853 31 9 33 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_32349_1120_1547_+ FIG00006764 31 8 32 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_32374_1161_1547_+ FIG00000659 30 7 31 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_32394_1_704_- FIG00007137 9 4 11 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_32416_1_643_- FIG00031250 6 7 27 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_32427_1_851_- FIG01956032 29 9 32 Tagatose 1,6-bisphosphate aldolase (EC 4.1.2.40) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_32444_1315_1545_+ FIG00503691 23 6 25 Cadmium-transporting ATPase (EC 3.6.3.3) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_32447_1_838_+ FIG00001712 69 16 72 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_32464_564_965_- FIG00001188 92 15 93 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_32498_697_972_- FIG00001264 14 3 16 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_32510_480_1031_+ FIG00000243 10 6 13 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_32582_1_309_+ FIG00001807 73 12 73 Indigoidine synthase A-like protein, uncharacterized enzyme involved in pigment biosynthesis CBSS-176299.3.peg.235 3 T2D_unique_32583_1_968_- FIG00002541 78 18 80 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_32603_1_164_- FIG00001563 5 2 6 Preprotein translocase subunit SecG (TC 3.A.5.1.1) Murein hydrolase regulation and cell death 1.2 T2D_unique_32624_254_1060_+ FIG00052605 51 11 55 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_32650_180_536_- FIG00135315 27 6 28 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_32831_1_152_- FIG00719736 11 4 13 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_32833_312_1058_+ FIG00090765 167 25 168 Lactose and galactose permease, GPH translocator family Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_32833_1085_1535_+ FIG00090765 19 3 20 Lactose and galactose permease, GPH translocator family Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_32839_234_1115_+ FIG00001882 50 17 55 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_32839_1223_1535_+ FIG00001882 14 6 15 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_32846_1250_1534_+ FIG00002239 76 11 76 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_32876_244_1029_+ FIG00000323 199 29 200 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_32876_1068_1534_+ FIG00000323 125 18 125 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_32909_996_1232_- FIG00543846 64 9 64 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_32914_176_1054_+ FIG00001406 93 19 95 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_32919_1_155_+ FIG00000351 31 6 31 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_32934_1051_1532_+ FIG00024396 116 19 116 LysR family transcriptional regulator STM3121 DNA-binding regulatory proteins, strays 1 T2D_unique_32941_1047_1532_+ FIG00000341 91 17 92 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_32971_118_1002_+ FIG00000441 241 35 241 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_32995_932_1530_- FIG00001469 140 20 141 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_33004_985_1530_- FIG00002742 5 4 6 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_33020_1_236_- FIG01318274 13 3 15 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_33031_835_1278_- FIG00002410 16 4 20 Recombinational DNA repair protein RecT (prophage associated) DNA repair, bacterial 3 T2D_unique_33089_1_318_+ FIG00020185 69 12 70 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_33089_398_1417_+ FIG00006551 37 20 124 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_33144_1195_1526_+ FIG00000304 67 12 67 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_33167_305_955_- FIG00000025 163 23 163 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_33167_958_1525_- FIG00000025 141 20 142 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_33182_656_1039_+ FIG00000191 32 7 34 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_33204_1057_1524_+ FIG00021289 27 7 28 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_33223_1125_1523_- FIG00004876 16 5 17 Acetaldehyde dehydrogenase, ethanolamine utilization cluster Fermentations: Mixed acid 1 T2D_unique_33249_1042_1254_+ FIG00002463 57 8 57 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_33304_869_1162_+ FIG01954533 32 6 33 Phosphocarrier protein of PTS system Fructose utilization 1 T2D_unique_33367_1_1083_+ FIG00000080 4 6 8 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_33416_948_1517_- FIG00000402 12 5 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_33455_1_289_+ FIG00139238 25 7 26 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_33467_1_907_- FIG00003788 3 3 5 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_33526_1_280_- FIG00000659 15 6 17 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_33571_1_284_- FIG00108342 23 5 24 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_33571_967_1302_- FIG00000309 8 3 9 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_33588_1119_1513_- FIG00139735 21 8 23 fructose sensor histidine kinase Fructose and Mannose Inducible PTS 2 T2D_unique_33636_1_656_- FIG00113099 10 2 12 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities CBSS-89187.3.peg.2957 1 T2D_unique_33641_949_1511_- FIG00010771 13 5 17 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_33653_1027_1511_+ FIG00002416 15 3 16 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_33660_1_130_+ FIG00000028 14 4 15 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_33660_153_1034_+ FIG00000241 131 24 133 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_33660_1076_1429_+ FIG00000241 27 5 29 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_33672_973_1332_- FIG00001577 16 5 18 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_33686_1_213_- FIG00001497 4 2 5 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Cell division-ribosomal stress proteins cluster 1 T2D_unique_33686_1285_1510_+ FIG00077620 9 3 11 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_33701_991_1182_- FIG00000402 19 3 20 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_33744_13_966_- FIG00000815 29 8 32 Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE Biogenesis of c-type cytochromes 1.1 T2D_unique_33744_1052_1508_- FIG00000747 4 2 5 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_33747_1_1105_+ FIG00080955 13 5 17 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_33788_733_1410_- FIG00086697 7 4 9 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_33829_563_1090_+ FIG00000465 98 14 100 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_33829_1111_1506_+ FIG00000465 58 11 59 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_33874_1_361_- FIG00001549 16 5 19 Hypothetical protein DUF901, similar to C-terminal domain of ribosome protection-type Tc-resistance proteins Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_33882_1038_1373_+ FIG01960218 81 13 81 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_33891_1171_1505_+ FIG00001198 13 3 15 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_33956_1_1074_+ FIG00001712 187 33 188 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_33965_1282_1503_- FIG00003596 5 3 7 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_34003_973_1502_- FIG01955782 41 12 42 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_34014_574_939_- FIG00000279 9 5 10 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_34014_957_1502_- FIG00000279 18 7 20 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_34029_1196_1501_+ FIG00003844 73 11 73 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_34063_30_476_+ FIG00000205 88 13 89 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_34072_1267_1416_+ FIG00002541 10 2 11 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_34085_234_845_- FIG00000700 7 2 10 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_unique_34114_861_1421_- FIG00000089 30 9 44 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_34119_1_1016_+ FIG00451095 15 7 17 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_34119_1022_1306_+ FIG00451095 3 2 5 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_34125_938_1282_- FIG00000163 73 11 73 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_34131_1112_1499_+ FIG01260980 50 11 51 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_34165_727_1498_- FIG00012814 7 3 9 Spore cortex-lytic enzyme, N-acetylglucosaminidase SleL (EC 3.2.1.-) Spore germination 1 T2D_unique_34202_1049_1294_+ FIG00011114 61 9 61 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_34231_1097_1497_+ FIG00067681 94 14 94 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_34234_63_1022_+ FIG00046929 80 19 82 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_34249_236_703_+ FIG00000113 135 18 135 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_34254_228_869_- FIG00002541 11 6 13 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_34309_404_1075_+ FIG00007729 108 17 109 Glycine betaine ABC transport system, ATP-binding protein OpuAA (EC 3.6.3.32) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_34309_1099_1494_+ FIG00007729 100 15 100 Glycine betaine ABC transport system, ATP-binding protein OpuAA (EC 3.6.3.32) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_34404_361_1491_+ FIG00001469 32 8 34 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_34409_1_533_- FIG00000387 66 15 67 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_34409_973_1110_- FIG00067300 14 2 14 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_34419_926_1261_- FIG00000367 46 7 47 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_34443_1334_1491_+ FIG00001491 35 6 35 Peroxide stress regulator PerR, FUR family Oxidative stress 1.2 T2D_unique_34457_1_488_- FIG00011659 84 15 85 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_34475_999_1277_- FIG00614545 15 3 16 Acylphosphate phosphohydrolase (EC 3.6.1.7), putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_34475_1292_1490_- FIG00031250 13 3 14 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_34487_1_654_- FIG00000184 187 25 187 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_34503_691_1035_+ FIG00009628 9 5 12 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_34519_1_1118_+ FIG00001269 124 22 126 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_34535_653_826_- FIG00451095 8 4 8 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_34537_1_378_- FIG00132801 7 5 8 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_34547_226_519_- FIG00009229 65 11 65 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_34573_992_1487_- FIG00067750 3 2 5 Metal-dependent hydrolases of the beta-lactamase superfamily II Beta-lactamase 1 T2D_unique_34636_88_588_+ FIG00000159 130 19 130 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_34658_851_1485_- FIG00000146 99 15 101 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_34661_50_925_- FIG00003251 39 11 40 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_34661_994_1386_- FIG00003251 33 7 34 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_34711_1202_1484_- FIG00000350 35 7 36 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_34742_518_1075_+ FIG00000863 12 5 15 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_34756_1_470_+ FIG00025216 45 11 47 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_34788_1_443_+ FIG00628860 30 6 32 Hypothetical protein Cj1505c Selenocysteine metabolism 1.1 T2D_unique_34794_997_1482_- FIG00000848 7 4 8 Manganese superoxide dismutase (EC 1.15.1.1) Oxidative stress 1.2 T2D_unique_34807_45_1013_+ FIG00000156 231 36 232 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_34815_1_633_+ FIG00000494 44 10 45 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_34816_1253_1420_+ FIG00067248 35 6 35 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_34817_817_1131_- FIG00229216 15 4 16 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_34822_1249_1481_+ FIG00135554 8 2 9 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_34826_1041_1475_+ FIG00003881 19 5 20 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_34844_1147_1481_+ FIG00000145 32 8 33 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_34877_1_240_- FIG00041038 24 3 24 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_34883_23_919_+ FIG00000289 223 34 224 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_34907_651_1091_+ FIG00006092 7 2 9 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_34918_126_734_- FIG00004528 53 9 54 Di-/tripeptide transporter Proton-dependent Peptide Transporters 1 T2D_unique_34928_1089_1478_+ FIG00024401 107 15 107 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_34939_1300_1443_+ FIG00007729 15 3 16 Glycine betaine ABC transport system, ATP-binding protein OpuAA (EC 3.6.3.32) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_34947_918_1478_- FIG00028461 19 6 22 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_34998_1_252_- FIG01030833 10 2 11 dTDP-Rha:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase WbbL dTDP-rhamnose synthesis 2.0 T2D_unique_35021_1_814_- FIG00044622 166 26 167 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_35065_1132_1475_- FIG00000015 19 5 21 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_35084_1160_1393_+ FIG00000892 15 4 16 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_35089_1111_1474_+ FIG00000911 94 14 94 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_35104_426_908_- FIG00002470 8 3 11 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_35122_1_133_+ FIG00000459 28 5 28 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_35138_1_746_+ FIG00019251 7 3 8 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_35145_1_479_- FIG00007514 66 14 67 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_35156_1065_1473_+ FIG00000824 9 4 10 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_35165_78_671_+ FIG00003460 4 3 7 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_35165_1003_1473_+ FIG00003506 11 4 14 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_35182_933_1472_- FIG00018699 127 18 128 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_35195_1_1080_+ FIG00000147 239 37 240 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_35202_1_408_+ FIG00023946 45 9 47 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_35225_1_791_- FIG00000011 16 7 19 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_35231_771_1010_+ FIG00000017 48 7 48 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_35232_1289_1471_- FIG00138258 32 6 33 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_35235_1_152_- FIG00000269 19 4 20 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_35255_1_309_- FIG00003715 49 9 50 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_35373_1023_1468_- FIG01310319 7 2 9 Exoenzymes regulatory protein AepA in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_35402_1_1051_+ FIG00000241 159 31 161 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_35434_1069_1467_+ FIG00000279 34 8 36 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_35449_671_1018_+ FIG00004744 31 6 33 Rare lipoprotein A precursor Peptidoglycan Biosynthesis 1.9 T2D_unique_35450_657_962_- FIG00000494 25 5 26 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_35450_986_1466_- FIG00000494 20 3 21 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_35466_1_939_+ FIG00000101 107 21 109 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_35466_1082_1466_+ FIG00000206 73 12 74 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_35476_1_665_- FIG00000450 80 18 81 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_35476_691_945_- FIG00000659 35 6 36 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_35476_987_1397_- FIG00000659 77 15 78 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_35503_1_1047_+ FIG00011537 127 28 128 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_35503_1053_1465_+ FIG00011537 69 11 71 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_35584_802_1005_+ FIG00001834 4 5 6 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_35584_1026_1463_+ FIG00001834 14 6 16 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_35607_711_1109_+ FIG00089707 21 5 22 Outer membrane protein H precursor Periplasmic Stress Response 1.1 T2D_unique_35614_1025_1384_+ FIG00000185 69 11 70 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_35633_1_888_- FIG00003845 252 35 253 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_35720_1_852_- FIG00001548 80 14 81 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_35725_1_649_+ FIG00018865 10 3 12 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_35728_1_1207_+ FIG00001076 17 4 19 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_35737_88_876_- FIG00000132 154 27 155 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_35769_816_986_- 7 4 10 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_35777_986_1458_- FIG00026918 127 18 128 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_35788_898_1308_- FIG00031250 4 4 5 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_35794_1_247_- FIG00000351 5 3 6 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_35832_1_381_+ FIG00000762 28 8 30 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_35832_989_1457_- FIG00010600 18 5 19 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_35833_909_1457_- FIG00000494 26 6 28 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_35846_1_486_+ FIG00037431 7 3 9 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_35856_1_205_- FIG01031896 11 4 12 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_35887_1_571_+ FIG00022300 30 8 33 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_35908_984_1455_- FIG00000207 105 16 106 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_35914_1_238_+ FIG00025209 42 8 42 Nicotinamidase/isochorismatase family protein NAD and NADP cofactor biosynthesis global E T2D_unique_35935_1021_1272_+ FIG00014849 12 3 15 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_35937_1011_1454_+ FIG00002614 4 2 6 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_35964_281_796_- FIG00000343 125 19 125 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_35974_1243_1453_- FIG00000370 11 3 12 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_36006_1_633_+ FIG00004172 10 4 13 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_unique_36039_845_1390_- FIG00000476 100 15 101 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_36041_1138_1452_+ FIG00001635 5 3 6 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_36047_1_726_- FIG00001469 160 24 162 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_36053_728_1042_+ FIG00001569 5 2 7 LysR family regulatory protein CidR Murein hydrolase regulation and cell death 1.2 T2D_unique_36076_904_1451_- FIG00006764 8 3 10 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_36108_1_613_- FIG00133515 12 6 15 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_36108_634_930_- FIG00000911 7 3 8 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_36119_601_900_- FIG00005243 7 4 8 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_36122_1_1003_+ FIG00029916 245 39 245 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_36122_1018_1221_+ FIG00029916 45 7 45 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_36122_1313_1450_+ FIG00003307 20 4 21 FIG003307: hypothetical protein CBSS-323097.3.peg.2594 1 T2D_unique_36135_260_985_- FIG01956038 175 28 175 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_unique_36147_1_344_- FIG00026137 49 8 50 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_36167_1_208_- FIG00010844 22 4 23 Flavodoxin Flavodoxin 1 T2D_unique_36194_497_772_- FIG01260980 16 4 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_36197_1_375_+ FIG00066425 45 9 46 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_36206_1_525_- FIG00007957 30 9 33 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_36228_1075_1281_+ FIG00000279 6 2 7 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_36232_1167_1447_- FIG00047509 15 5 16 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_36248_977_1446_- FIG00108342 40 9 41 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_36261_1_252_- FIG00001188 11 2 12 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_36261_312_950_- FIG00018865 15 8 17 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_36261_989_1300_- FIG00018865 8 5 10 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_36305_1100_1445_+ FIG01958907 5 2 6 Phage terminase Phage head and packaging 1 T2D_unique_36318_584_1006_+ FIG00001675 4 4 7 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_36338_1_560_- FIG00002049 35 12 37 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_36338_571_972_- FIG00455853 26 6 29 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_36338_981_1444_- FIG00455853 21 6 22 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_36342_1011_1444_+ FIG00001882 21 6 26 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_36362_1105_1443_- FIG00451095 6 3 7 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_36382_965_1443_- FIG00001385 6 3 12 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_36386_940_1443_- FIG00000329 121 17 122 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_36456_791_1054_+ FIG00000206 50 8 51 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_36457_1019_1441_+ FIG00001020 46 10 47 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_36482_1171_1341_+ FIG00004788 41 6 41 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_36515_1033_1439_+ FIG00000420 8 5 12 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_36588_1168_1437_+ FIG00000086 52 8 52 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_36598_1003_1437_- FIG00006336 102 15 102 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_36607_1_540_- FIG00000464 135 21 136 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_36609_96_530_- FIG00000621 110 16 110 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_36615_990_1436_- FIG00011468 11 4 13 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_36678_537_953_- FIG00000477 47 9 48 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_36684_1007_1434_+ FIG00000224 14 5 15 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_36721_1_314_- FIG00001676 22 4 23 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_36751_1_208_- FIG00000422 6 2 7 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_36763_1265_1432_- FIG00000101 9 3 10 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_36811_992_1431_- FIG00001865 55 9 56 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_36839_1_1058_+ FIG00001269 274 39 275 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_36839_1193_1430_+ FIG00001269 62 9 62 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_36842_1_1065_+ FIG00050243 262 38 263 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_36849_992_1393_- FIG00451095 78 11 78 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_36898_1084_1429_- FIG00000402 5 2 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_36916_989_1428_- FIG01955844 49 10 50 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_37037_817_948_- FIG00000380 12 3 13 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_37066_614_1009_+ FIG00000043 26 6 27 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_37164_255_1019_+ FIG01956356 150 26 151 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_37232_712_921_- FIG00075970 5 2 8 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_37263_1_536_- FIG00000377 137 21 137 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_37333_1_239_- FIG00088067 6 2 7 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_37348_1050_1418_- FIG00000673 83 12 84 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_unique_37365_1_1020_+ FIG00000372 11 8 28 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_37408_30_692_- FIG00010818 23 5 25 L-serine dehydratase, beta subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_37416_1_474_+ FIG01304818 134 19 134 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_37416_533_1027_+ FIG00000315 123 18 123 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_37463_805_1317_- FIG00001029 67 11 68 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_37468_1288_1415_+ FIG00008941 18 4 19 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_37528_1128_1414_+ FIG00000448 73 11 73 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_37547_1_1025_+ FIG00000188 187 31 188 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_37560_1_221_- FIG00010600 52 8 53 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_37599_1_145_- FIG00047414 31 5 31 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_37599_356_1027_+ FIG00000422 9 3 11 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_37612_1_237_+ FIG00000047 11 3 12 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_37632_450_746_- FIG00016888 7 3 8 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_37639_941_1099_- FIG00846773 11 2 12 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_37708_43_432_- FIG00086697 44 8 45 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_37737_998_1342_- FIG00846773 11 4 12 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_37752_1_981_- FIG00003174 44 16 46 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_37759_932_1408_- FIG00003472 70 14 71 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_37761_1077_1408_+ FIG00044622 39 7 41 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_37786_196_1008_+ FIG00000352 105 19 107 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_37842_1_373_- FIG00006691 9 4 11 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_37843_218_484_- FIG00002199 27 4 28 Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11) Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_37852_1251_1406_+ FIG00719736 8 3 9 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_37890_815_1105_+ FIG00075970 21 5 22 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_37997_1031_1403_+ FIG01260980 46 10 47 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_38104_1_412_+ FIG00000895 57 13 58 Alanine dehydrogenase (EC 1.4.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_38114_1_1054_+ FIG00001311 47 11 51 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_unique_38183_1_870_- FIG00046929 50 12 52 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_38219_1038_1398_+ FIG00000075 6 4 8 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_38221_1123_1398_- FIG00000815 9 4 10 Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE Biogenesis of c-type cytochromes 1.1 T2D_unique_38234_1_552_- FIG00018369 10 2 13 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_38242_597_920_- FIG00109688 7 3 8 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_38268_1_176_- FIG00000146 38 7 38 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_38279_985_1397_- FIG00035175 61 11 63 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_38280_690_1109_- FIG00009395 16 4 17 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_unique_38285_1127_1397_+ FIG00000111 68 10 68 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_38288_1_694_- FIG00006691 160 24 161 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_38318_1136_1396_+ FIG00002463 10 2 11 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_38332_1_185_- FIG00091606 43 7 43 Methionine synthase activation domain (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_38332_344_931_- FIG00000453 138 22 140 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_38332_985_1200_- FIG00000453 42 6 43 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_38333_1_960_- FIG00093180 26 11 29 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_38345_1131_1280_+ FIG00067300 35 5 35 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_38348_1_305_+ FIG00066280 81 12 81 V-type ATP synthase subunit G (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_38350_980_1395_+ FIG00001548 34 8 35 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_38357_1_1008_+ FIG00005216 95 23 97 Sulfate permease Cysteine Biosynthesis 2.17 T2D_unique_38366_1014_1331_- FIG00000198 18 5 21 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_38381_1_393_- FIG00001642 98 15 98 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_38407_1_547_+ FIG00005237 133 20 133 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_38426_968_1129_- FIG00005172 4 2 5 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_38434_863_1294_- FIG00000267 28 9 30 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_38440_849_1393_- FIG00047509 66 12 67 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_38454_1254_1393_+ FIG00109688 6 2 8 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_38470_1_310_+ FIG00034851 21 7 22 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_38481_1250_1392_+ FIG00001469 4 2 5 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_38483_49_957_+ FIG00009149 79 20 83 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_38497_833_1392_- FIG00001531 7 3 9 D-alanyl transfer protein DltB D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_38501_871_1392_- FIG00028882 75 13 76 D-glycerate transporter (predicted) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_38515_1131_1392_+ FIG00000329 21 6 22 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_38520_101_445_- FIG00000325 4 2 5 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_38534_638_823_- FIG00002849 18 4 19 Putative predicted metal-dependent hydrolase Restriction-Modification System 3.x T2D_unique_38554_1_209_- FIG00003086 14 5 15 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_38554_228_731_- FIG00079740 28 5 29 Xyloside transporter XynT Xylose utilization 1 T2D_unique_38559_1_473_- FIG00139192 31 7 32 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_38597_1229_1390_- FIG00000433 3 2 9 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_38607_1_128_+ FIG00000216 11 2 12 LSU ribosomal protein L20p Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins) 1 T2D_unique_38634_1005_1389_- FIG01016270 13 4 14 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_38650_487_1059_+ FIG00000680 142 21 143 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_38650_1200_1389_+ FIG00000680 50 7 50 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_38678_1143_1388_- FIG01318274 10 2 12 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_38716_597_980_+ FIG00045144 16 6 18 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_38790_993_1232_- FIG00000241 24 4 25 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_38833_977_1385_- FIG00024401 29 7 30 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_38837_985_1134_- FIG00135315 9 3 10 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_38840_560_1048_+ FIG00007586 89 16 90 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_38840_1053_1376_+ FIG00007039 77 12 77 Multiple sugar ABC transporter, membrane-spanning permease protein MsmG Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_38868_1_823_- FIG00000268 209 30 209 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_38868_1041_1385_- FIG00036983 88 14 88 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_38872_1048_1384_+ FIG00003756 40 9 41 Maltose-6'-phosphate glucosidase (EC 3.2.1.122) Maltose and Maltodextrin Utilization 1.x T2D_unique_38875_1059_1384_+ FIG00001882 62 10 62 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_38913_983_1384_- FIG00006764 112 15 112 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_38920_1_1020_+ FIG00005216 112 22 116 Sulfate permease Cysteine Biosynthesis 2.17 T2D_unique_38920_1026_1384_+ FIG00005216 9 6 23 Sulfate permease Cysteine Biosynthesis 2.17 T2D_unique_38929_1050_1331_+ FIG00000283 4 2 5 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_38935_19_993_- FIG00687285 285 39 285 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_unique_38935_996_1383_- FIG00687285 100 15 100 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_unique_38961_1167_1383_- FIG00001469 3 2 4 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_39003_934_1382_- FIG00000372 11 3 12 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_39034_1_170_- FIG00001188 4 3 5 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_39080_1114_1380_- FIG00013339 6 3 8 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_39121_1000_1379_+ FIG00000445 111 15 111 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_39123_1230_1379_+ FIG00000391 11 2 12 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_39145_1_398_- FIG00000405 42 9 43 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_39159_344_1027_+ FIG00046929 56 13 58 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_39159_1108_1379_+ FIG00046929 29 6 31 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_39174_400_1011_+ FIG00000895 4 4 5 Alanine dehydrogenase (EC 1.4.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_39187_1_537_+ FIG00000575 13 5 14 L-aspartate oxidase (EC 1.4.3.16) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_39187_569_1000_+ FIG00000413 19 5 21 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_39187_1045_1353_+ FIG00000413 13 4 15 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_39199_1090_1378_- FIG00051439 15 4 16 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_39207_1_924_+ FIG00000695 217 31 218 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_39225_1016_1377_+ FIG00000015 11 5 13 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_39228_979_1377_- FIG00002251 95 15 95 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_39232_922_1377_- FIG01292786 12 6 14 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_39257_974_1376_- FIG00000402 3 3 4 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_39277_590_856_- FIG00000147 4 2 6 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_39277_922_1376_- FIG00133288 6 4 12 Excinuclease ABC subunit A, dimeric form DNA repair, UvrABC system 1 T2D_unique_39341_1_911_- FIG00000571 42 10 43 Signal transduction histidine kinase CheA (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_unique_39341_944_1321_- FIG00000571 58 9 59 Signal transduction histidine kinase CheA (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_unique_39392_1048_1373_+ FIG00001548 25 6 26 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_39400_1_142_+ FIG00005283 32 5 32 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_39410_1_864_- FIG00023943 12 5 16 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_39413_1_1005_+ FIG00000402 13 7 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_39416_870_1256_- FIG00000112 23 6 25 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_39419_1_1177_+ FIG00001469 28 12 31 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_39458_979_1372_- FIG00025216 74 13 74 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_39490_1_134_- FIG00000175 17 4 18 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_39517_1067_1306_+ FIG00000402 12 4 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_39538_1_467_+ FIG00077620 51 10 52 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_39602_828_1025_+ FIG00029916 44 6 44 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_39602_1037_1369_+ FIG00029916 81 13 81 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_39619_959_1144_- FIG00013156 10 2 12 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_39673_1220_1368_- FIG00033206 39 6 39 Enoyl-CoA hydratase (EC 4.2.1.17) Polyhydroxybutyrate metabolism 5.6 T2D_unique_39675_949_1368_- FIG00000011 101 14 102 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_39701_899_1367_- FIG00745599 63 12 70 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_39714_1_214_+ FIG00002049 34 7 34 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_39831_989_1365_+ FIG00030688 80 12 80 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_39922_1_462_+ FIG00044478 37 10 39 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_39981_1_1097_+ FIG00001469 70 16 74 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_40005_1_633_- FIG00000208 154 24 154 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_40020_995_1312_- FIG00138182 4 2 5 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_40022_964_1248_- FIG00016566 50 7 50 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_40036_179_490_- FIG00140752 67 11 68 PTS system, fructose- and mannose-inducible putative EII component Fructose and Mannose Inducible PTS 2 T2D_unique_40069_956_1360_- FIG00005283 16 5 18 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_40072_965_1360_- FIG00001548 9 4 10 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_40080_1032_1360_+ FIG01304601 19 5 20 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_40113_945_1295_- FIG00018699 66 11 66 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_40130_986_1359_- FIG00041038 35 10 37 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_40137_982_1359_+ FIG00003088 11 5 13 Arsenical pump-driving ATPase (EC 3.6.3.16) Arsenic resistance 1 T2D_unique_40139_978_1359_- FIG00000385 99 14 100 Cell division protein FtsA Cell Division Cluster 1.x T2D_unique_40161_1_618_+ FIG00093180 31 8 33 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_40164_864_1307_+ FIG00000080 83 12 84 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_40169_952_1358_- FIG00012446 39 8 41 Spore germination protein YpeB Spore germination 1 T2D_unique_40199_1044_1358_- FIG00000962 45 8 46 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_40210_921_1253_- FIG00002560 8 5 9 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_40211_157_921_- FIG00000441 210 30 210 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_40223_1_459_+ FIG00052605 95 15 96 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_40225_1_284_+ FIG00022976 31 7 32 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_40229_232_1017_+ FIG00024401 200 29 201 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_40235_895_1357_- FIG00000364 17 5 18 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) Coenzyme A Biosynthesis A.191 T2D_unique_40276_1_743_- FIG01260980 36 10 37 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_40290_1095_1355_+ FIG00048580 21 4 23 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_40317_1_750_- FIG00000165 92 22 94 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_40318_1193_1355_+ FIG00133515 5 3 6 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_40342_203_1003_+ FIG00007729 41 11 57 Glycine betaine ABC transport system, ATP-binding protein OpuAA (EC 3.6.3.32) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_40342_1039_1354_+ FIG00007729 19 3 19 Glycine betaine ABC transport system, ATP-binding protein OpuAA (EC 3.6.3.32) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_40351_1_355_+ FIG00008591 20 7 22 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_40351_370_1011_+ FIG00007714 12 5 15 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_40371_507_1010_+ FIG00038456 31 8 32 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_40371_1019_1354_+ FIG00038456 9 4 11 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_40372_87_479_- FIG00039528 89 14 89 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) Purine conversions 4.1118100 T2D_unique_40394_44_976_- FIG00002914 61 16 98 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_40403_1077_1353_+ FIG00005727 50 8 51 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_40508_780_1064_+ FIG00035175 7 3 9 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_40517_1_329_+ FIG00016145 28 7 30 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_unique_40517_334_1068_+ FIG00000642 66 16 67 Spermidine synthase (EC 2.5.1.16) Polyamine Metabolism 2 T2D_unique_40517_1174_1351_+ FIG00052802 23 4 23 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_unique_40520_1001_1351_+ FIG00001635 12 4 14 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_40542_1_811_- FIG00001882 188 29 188 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_40574_1_438_+ FIG00004014 95 15 97 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_40574_487_1029_+ FIG00003881 130 19 131 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_40580_1_1076_+ FIG00016514 63 16 65 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_40584_1_308_- FIG00086697 5 3 6 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_40589_1_773_+ FIG00017190 11 4 13 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_40589_1043_1349_+ FIG00030797 38 7 39 C4-type zinc finger protein, DksA/TraR family Zinc regulated enzymes 1 T2D_unique_40598_1151_1349_+ FIG00002541 8 2 10 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_40610_907_1349_- FIG00001548 94 13 95 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_40624_170_460_- FIG00002914 45 8 45 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_40629_1_945_+ FIG01260980 117 22 119 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_40637_1038_1348_+ FIG00052605 4 2 5 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_40651_938_1348_- FIG00000032 3 3 5 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_40657_918_1348_- FIG00000510 42 11 43 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_40706_1_234_+ FIG00018457 6 3 8 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_40735_37_882_- FIG00000911 36 10 37 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_40750_903_1346_- FIG01260980 77 12 78 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_40798_1216_1345_+ FIG00000290 7 2 8 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_40875_1_693_+ FIG00036224 6 3 8 Sialidase (EC 3.2.1.18) Sialic Acid Metabolism 1.x T2D_unique_40891_640_963_- FIG00000328 46 8 47 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_40910_478_828_- FIG00000328 48 9 49 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_40949_1212_1342_+ FIG00133226 4 2 4 Dihydrolipoamide dehydrogenase of acetoin dehydrogenase (EC 1.8.1.4) Acetoin, butanediol metabolism 5 T2D_unique_41029_524_985_- FIG00034392 99 16 100 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_41029_991_1340_- FIG00034392 83 13 84 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_41035_1_633_- FIG00000370 53 13 55 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_41054_1000_1340_+ FIG00000116 51 11 52 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_41080_1087_1340_+ FIG00132839 25 5 26 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_41088_1047_1339_+ FIG00024401 11 3 13 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_41144_243_581_- FIG00133325 7 3 9 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_41155_1_428_- FIG00000245 44 8 45 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_41165_134_1009_+ FIG00000402 174 28 175 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_41199_1041_1337_+ FIG00000025 63 11 63 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_41248_1048_1336_+ FIG00000165 65 11 65 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_41286_1174_1335_- FIG01304886 6 2 7 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_unique_41289_340_861_- FIG00000397 144 21 144 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_41289_978_1133_- FIG00000397 28 5 29 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_41301_1090_1335_- FIG00000117 20 6 21 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_41331_1101_1335_+ FIG00000494 17 4 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_41353_1016_1334_+ FIG00451095 5 3 7 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_41360_1_264_+ FIG00000464 6 2 8 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_41375_535_1005_+ FIG00019652 120 18 120 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_41375_1193_1334_+ FIG00133569 22 4 22 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_41398_1084_1333_+ FIG00000552 56 8 56 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_41409_305_871_- FIG00001882 146 22 146 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_41428_1180_1333_- FIG00000542 33 5 34 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_41431_317_913_- FIG00021289 50 11 52 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_41431_970_1333_- FIG00021289 45 9 46 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_41435_881_1333_- FIG00001377 59 12 60 Pyruvate oxidase [ubiquinone, cytochrome] (EC 1.2.2.2) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_41440_49_885_+ FIG01304229 229 32 230 MSM (multiple sugar metabolism) operon regulatory protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_41442_1151_1333_+ FIG00000430 5 2 6 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_unique_41444_973_1333_- FIG00000134 81 13 82 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_41454_926_1332_- FIG00047509 58 9 60 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_41456_1085_1332_+ FIG00001712 27 7 29 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_41474_432_1028_+ FIG00002049 109 19 109 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_41487_1_295_- FIG00003788 68 11 68 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_41498_588_1001_+ FIG00000659 48 10 49 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_41498_1016_1303_+ FIG00000659 15 4 16 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_41512_1_530_+ FIG00000527 152 21 152 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_41522_966_1295_- FIG00000190 73 12 73 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_41539_947_1195_- FIG00000695 22 5 23 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_41570_498_1076_+ FIG00004014 20 6 25 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_41572_1_303_+ FIG00000803 32 7 34 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_unique_41581_1_224_+ FIG00009156 3 2 4 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_41581_997_1330_- FIG00012746 23 5 25 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_41592_153_914_- FIG00016663 10 8 13 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_41604_904_1329_- FIG01260980 26 7 27 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_41635_951_1329_- FIG00002311 84 13 84 Septation ring formation regulator EzrA CBSS-393130.3.peg.794 2 T2D_unique_41636_68_910_- FIG00001547 197 30 198 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_41636_955_1329_- FIG00001547 20 4 28 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_41650_177_1067_- FIG00000838 55 16 68 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_41680_978_1328_- FIG00000098 20 6 22 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_41682_1_316_+ FIG00000147 44 7 45 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_41694_1_936_- FIG00002020 267 36 268 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_41694_996_1327_- FIG00002020 91 13 91 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_41730_985_1327_- FIG00066643 18 5 20 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_41756_1_595_+ FIG00000221 146 23 146 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_41763_1_548_+ FIG00002328 5 3 7 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_41763_556_1014_+ FIG00000411 4 3 8 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_41806_1_730_+ FIG00138258 186 28 186 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_41835_71_937_- FIG00002944 76 14 77 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_unique_41835_969_1325_- FIG00000717 24 8 25 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_41841_1_236_+ FIG00007328 9 2 10 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_41841_313_1324_+ FIG00006649 15 6 19 Glutathione biosynthesis bifunctional protein gshF (EC 6.3.2.2)(EC 6.3.2.3) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_41850_1_519_- FIG00000721 27 7 29 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_41850_540_863_- FIG00002541 28 6 30 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_41894_1_207_+ FIG00000383 8 3 9 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_41914_1_232_- FIG00010675 8 3 9 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_unique_41967_780_941_- FIG00000990 9 3 10 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_41983_992_1322_- FIG00000080 72 12 73 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_41989_1_340_- FIG00000695 12 4 13 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_42025_121_954_+ FIG00005860 238 33 238 SusD, outer membrane protein Cellulosome 1.x T2D_unique_42051_1114_1321_+ FIG00138523 53 8 53 Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_unique_42055_1_606_+ FIG00093180 28 8 29 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_42063_108_581_- FIG00031250 3 2 5 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_42083_1_180_+ FIG00000076 27 4 28 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_42092_1_1064_+ FIG00004655 292 40 293 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_42092_1073_1320_+ FIG00004655 50 9 50 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_42105_1_1127_+ FIG00002541 87 18 89 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_42121_1_967_- FIG00001088 287 40 287 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_42121_994_1319_- FIG00001088 75 11 76 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_42128_975_1319_- FIG00001547 30 7 31 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_42152_1078_1319_- FIG00000370 6 3 7 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_42156_48_740_+ FIG00022976 70 15 72 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_42165_1_507_+ FIG00000392 62 11 63 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_42167_869_1318_- FIG00002541 49 10 51 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_42170_321_899_- FIG00007941 110 19 111 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_42274_489_1202_+ FIG00001208 34 9 36 [NiFe] hydrogenase metallocenter assembly protein HypD NiFe hydrogenase maturation 1 T2D_unique_42287_1_440_+ FIG00000241 12 5 13 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_42292_993_1316_- FIG00000717 88 12 88 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_42316_1134_1316_+ FIG00745599 8 2 9 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_42321_928_1104_- FIG00050603 21 4 22 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_42324_988_1316_- FIG00004308 32 5 34 N-acetylglucosamine related transporter, NagX Chitin and N-acetylglucosamine utilization 2 T2D_unique_42325_1_771_+ FIG00001366 10 7 14 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_42377_24_851_+ FIG00002163 201 28 202 Rhamnulose-1-phosphate aldolase (EC 4.1.2.19) L-rhamnose utilization 1 T2D_unique_42381_1_812_- FIG00026918 31 7 33 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_42385_1037_1315_+ FIG00005112 46 9 46 Trehalose synthase (EC 5.4.99.16) Trehalose Biosynthesis 1.2 T2D_unique_42391_605_967_- FIG00002049 24 6 25 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_42418_1050_1314_+ FIG00009149 25 8 27 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_42423_965_1314_- FIG00010600 4 2 5 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_42425_961_1314_- FIG00007941 12 3 13 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_42427_1_482_- FIG00000388 3 2 5 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_42452_1_875_+ FIG00002141 245 34 246 Competence protein CoiA Gram Positive Competence 3100 T2D_unique_42489_1_991_- FIG00016061 95 18 98 L-lactate permease Lactate utilization 3 T2D_unique_42499_474_983_+ FIG00000159 7 3 9 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_42504_141_764_+ FIG00000103 19 4 21 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_42504_781_1017_+ FIG00023369 45 8 45 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_42504_1059_1312_+ FIG00023369 24 7 25 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_42511_1_248_- FIG00000128 56 10 56 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_42525_1037_1312_+ FIG00016566 29 6 30 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_42536_1_269_- FIG00000494 26 7 30 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_42570_1_1007_+ FIG00052730 256 38 258 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_42570_1013_1294_+ FIG00052730 57 9 58 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_42576_1_907_- FIG00000482 59 15 65 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_42605_989_1138_- FIG00067248 24 4 25 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_42640_1159_1310_+ FIG01260980 4 3 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_42641_519_974_- FIG00000261 31 8 33 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_42656_260_913_- FIG00002847 56 12 58 HflK protein Hfl operon 1.111 T2D_unique_42695_1_471_- FIG00022300 116 17 116 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_42715_8_286_+ FIG01031896 24 5 27 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_42850_1110_1306_+ FIG00021289 33 5 34 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_42913_987_1259_- FIG00139491 40 8 41 NAD-reducing hydrogenase subunit HoxE (EC 1.12.1.2) Hydrogenases 2 T2D_unique_42926_254_445_- FIG00000477 5 2 6 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_42936_1_491_+ FIG00000450 24 6 26 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_42950_1126_1304_+ FIG00001385 13 3 17 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_42957_630_1274_+ FIG00067681 51 9 52 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_42962_1037_1304_+ FIG00067300 25 6 26 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_42971_1178_1304_+ FIG00001269 14 3 15 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_42980_1_503_+ FIG00001406 87 15 88 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_43005_481_999_+ FIG00022899 78 15 79 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_43005_1101_1303_+ FIG00006463 46 8 46 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_43031_975_1303_- FIG00093180 3 2 4 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_43032_817_1029_+ FIG00561498 8 2 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_43033_1018_1302_+ FIG00004078 30 6 35 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_43045_1013_1302_- FIG00010844 73 11 73 Flavodoxin Flavodoxin 1 T2D_unique_43049_578_904_- FIG00000595 75 13 75 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_43062_1_434_+ FIG00000522 10 4 11 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_43143_1_961_- FIG01304430 51 14 54 putative ATP-dependent DNA helicase YjcD DNA repair, bacterial UvrD and related helicases 1 T2D_unique_43148_1026_1300_+ FIG00000151 11 4 13 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_43160_1_222_- FIG00005547 26 5 27 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_unique_43161_937_1266_- FIG00002387 66 10 67 Phosphatidylglycerophosphatase B (EC 3.1.3.27) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_43181_1158_1300_+ FIG01260980 11 3 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_43204_1081_1299_+ FIG00138523 11 4 12 Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_unique_43219_481_939_- FIG00052867 5 2 7 Predicted rhamnose oligosaccharide ABC transport system, permease component 2 L-rhamnose utilization 1 T2D_unique_43257_1013_1299_+ FIG00001189 29 7 30 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_43265_398_1048_+ FIG00001865 58 13 60 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_43273_1003_1298_+ FIG00022488 74 11 74 Gluconate permease D-gluconate and ketogluconates metabolism 1.3 T2D_unique_43294_909_1298_- FIG00000494 24 5 25 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_43295_114_848_- FIG01239241 14 7 20 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_43295_914_1298_- FIG01304636 89 12 89 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_43340_186_548_+ FIG00092649 36 8 37 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_43340_887_1297_+ FIG00130900 23 6 24 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_unique_43354_1161_1297_+ FIG00000258 16 4 17 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_43365_286_774_- FIG00002716 114 17 115 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_43385_1_1016_+ FIG00000877 180 31 181 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_43405_364_975_- FIG00012067 51 11 52 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_43409_976_1296_- FIG00001189 44 7 45 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_43410_1066_1296_+ FIG00000477 31 5 32 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_43416_1073_1296_+ FIG00000145 18 5 19 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_43432_1041_1296_+ FIG00134060 37 8 38 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_43433_748_1035_+ FIG00000494 3 2 6 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_43446_493_975_- FIG00003174 15 4 17 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_43458_944_1108_- FIG00001384 15 3 16 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_43470_131_325_- FIG01546819 7 2 8 TPP-requiring enzyme co-localized with putative O-antigen rfb gene cluster Acetoin, butanediol metabolism 5 T2D_unique_43491_769_1245_+ FIG00000355 23 7 25 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_43510_1_172_- FIG00016514 14 4 15 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_43535_1_506_- FIG00561498 100 17 100 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_43536_984_1293_- FIG00000121 33 7 34 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_43552_1_157_+ FIG00042616 5 2 6 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_43570_381_1007_+ FIG00001882 9 2 10 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_43582_1_440_- FIG01304636 46 10 47 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_43611_763_1292_- FIG00340853 57 10 58 Oxalyl-CoA decarboxylase (EC 4.1.1.8) Glycolate, glyoxylate interconversions ? T2D_unique_43634_978_1292_- FIG00000279 66 11 66 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_43637_1_953_- FIG00000402 156 28 157 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_43641_1162_1291_- FIG00133292 19 4 19 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_43649_1098_1291_- FIG00022899 26 5 27 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_43658_1064_1291_+ FIG00018699 57 9 57 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_43660_1105_1291_- FIG00001635 21 4 22 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_43687_351_515_+ FIG00000471 33 5 33 LSU ribosomal protein L34p Cell Division Subsystem including YidCD 1 T2D_unique_43687_564_932_+ FIG00092649 100 14 100 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_43700_1_338_+ FIG00000149 15 7 16 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_43720_1_910_- FIG00000422 259 36 259 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_43720_922_1290_- FIG00000422 80 11 81 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_43729_8_163_+ FIG00133569 31 6 31 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_43734_1_689_- FIG00000825 129 22 130 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_43762_1_192_- FIG00000793 41 7 41 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_43764_1016_1290_+ FIG00026918 20 6 21 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_43775_945_1220_- FIG00010738 27 6 28 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_43815_1_469_+ FIG00006691 43 8 45 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_43848_36_584_- FIG00001306 146 22 146 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_unique_43852_1016_1207_+ FIG00745599 50 7 50 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_43853_1085_1288_+ FIG00000764 7 3 8 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_43855_1_711_- FIG00113099 15 8 17 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities CBSS-89187.3.peg.2957 1 T2D_unique_43859_993_1288_- FIG00134486 48 9 50 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_43885_986_1288_- FIG00001548 82 11 82 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_43929_1118_1287_+ FIG00138443 36 6 36 Mgl repressor and galactose ultrainduction factor GalS, HTH-type transcriptional regulator Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_43932_1_290_+ FIG00001819 26 7 27 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_43955_278_502_- FIG00000394 34 6 34 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_43974_1_374_- FIG00000190 7 3 8 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_43997_1036_1286_+ FIG00000056 59 9 59 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_44060_50_931_- FIG00719736 27 12 29 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_44060_943_1227_- FIG00719736 9 4 10 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_44065_483_974_+ FIG00009395 114 18 114 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_unique_44066_1_901_- FIG01260980 60 16 62 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_44069_1_1130_+ FIG00002049 15 7 17 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_44081_1_436_- FIG00000287 91 13 92 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_44082_1_406_+ FIG00000522 7 2 9 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_44115_1_473_- FIG00007508 26 8 29 Nitrite reductase probable [NAD(P)H] subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_unique_44115_477_923_- FIG00011102 19 8 21 Nitrite reductase probable electron transfer 4Fe-S subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_unique_44118_672_1010_+ FIG00001067 52 9 53 Rubrerythrin Oxidative stress 1.2 T2D_unique_44134_913_1284_- FIG00007941 74 11 76 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_44141_1_419_- FIG00076542 10 3 11 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_44165_839_1283_+ FIG00008591 40 7 42 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_44217_1044_1282_+ FIG00067681 16 5 17 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_44226_300_890_- FIG00002541 165 24 165 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_44226_995_1282_- FIG00002541 75 11 75 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_44233_426_1172_+ FIG00000210 129 20 130 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_44234_1_457_- FIG00011651 18 7 19 Two-component response regulator colocalized with HrtAB transporter Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_44243_797_1282_- FIG00002839 41 9 42 MutS-related protein, family 1 DNA repair, bacterial MutL-MutS system 1 T2D_unique_44281_1_671_+ FIG00000402 183 25 185 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_44289_1046_1281_+ FIG00016663 28 5 29 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_44297_1_776_- FIG00018865 27 13 32 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_44297_922_1281_- FIG00002049 6 4 9 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_44316_308_655_- FIG00000271 13 6 14 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_unique_44326_938_1280_- FIG00015230 41 7 41 Outer membrane porin protein NmpC precursor Uptake of selenate and selenite 1.1 T2D_unique_44355_1_351_+ FIG00139735 92 14 92 fructose sensor histidine kinase Fructose and Mannose Inducible PTS 2 T2D_unique_44365_969_1280_- FIG00011468 9 2 10 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_44367_1147_1280_+ FIG00001547 3 3 4 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_44399_1_923_- FIG00000070 212 34 212 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_44399_978_1279_- FIG00023369 68 11 68 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_44424_4_465_- FIG00037431 80 15 92 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_44431_991_1278_- FIG00001667 10 3 11 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_44473_1_416_+ FIG00000208 23 7 24 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_44490_1_548_- FIG00038343 3 2 5 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_44592_905_1048_+ FIG00001469 17 3 17 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_44624_693_938_- FIG01007502 55 9 55 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_44624_995_1275_- FIG01007502 61 10 61 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_44635_1036_1275_- FIG00000198 10 3 11 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_44651_62_703_- FIG00561498 40 10 42 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_44654_1028_1274_+ FIG00001548 13 4 14 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_44659_1_425_- FIG00149566 83 14 83 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_44661_1080_1274_+ FIG00026918 30 5 31 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_44666_1_572_- FIG00000188 30 7 32 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_44668_310_528_- FIG00006169 7 3 8 YoeB toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_44702_1_998_+ FIG00001280 20 9 25 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_44763_919_1273_- FIG00001029 67 11 68 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_44790_1_234_- FIG00000032 36 7 36 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_44862_995_1271_- FIG00002620 53 9 54 Tyrosine-protein kinase transmembrane modulator EpsC Exopolysaccharide Biosynthesis 1.0 T2D_unique_44867_1109_1271_+ FIG00554193 14 3 15 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_44875_1003_1271_+ FIG00059211 11 3 12 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_44878_962_1271_- FIG00051439 70 10 72 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_44892_116_520_- FIG00001298 18 5 21 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_44892_556_948_- FIG00000086 46 8 48 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_44920_1_439_+ FIG00001547 6 3 8 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_44929_1_651_+ FIG00086220 27 6 31 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_44929_829_1270_- FIG00007025 31 6 32 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_44982_464_712_+ FIG00002968 6 3 8 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_45029_1121_1269_+ FIG00000139 13 3 14 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_45071_441_1043_+ FIG00019251 96 17 98 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_45072_1024_1268_+ FIG00016566 18 4 19 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_45098_1061_1267_+ FIG00000594 6 2 7 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_45114_874_1267_- FIG00847085 19 5 21 beta-hexosaminidase precursor Purine Utilization 1 T2D_unique_45138_678_935_- FIG00000098 54 10 55 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_45158_1_259_+ FIG00006165 3 3 5 Uracil-DNA glycosylase, family 4 Uracil-DNA glycosylase 1 T2D_unique_45172_1_718_- FIG00451095 188 27 189 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_45172_994_1143_- FIG00451095 21 5 21 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_45178_911_1266_- FIG00042267 3 3 5 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_45185_1_359_+ FIG00000147 10 4 11 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_45198_1_576_+ FIG00052605 167 23 167 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_45200_1_156_+ FIG01255877 10 3 10 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_45223_1_303_- FIG00134830 5 3 8 Lysine 2,3-aminomutase (EC 5.4.3.2) Lysine degradation 1.0 T2D_unique_45240_493_1080_+ FIG00042267 3 7 35 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_45247_1096_1265_+ FIG00001548 16 5 17 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_45254_1_505_- FIG00846773 18 5 20 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_45279_989_1264_- FIG00009395 5 3 6 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_unique_45299_354_1124_+ FIG00561498 155 24 156 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_45321_902_1264_- FIG00001062 51 9 53 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_unique_45323_794_1075_+ FIG01290653 9 3 10 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_45338_1_333_+ FIG00000782 20 5 21 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_45374_1_344_- FIG00001134 13 2 14 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_unique_45411_987_1262_- FIG00021289 13 5 15 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_45419_1123_1262_+ FIG01955850 14 4 15 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_45436_1_411_+ FIG00229199 82 13 82 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_45449_964_1261_- FIG00000336 46 7 48 Cytosol aminopeptidase PepA (EC 3.4.11.1) EC 3.4.11.- Aminopeptidases 1 T2D_unique_45485_1_629_+ FIG00007137 21 7 23 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_45489_682_915_- FIG00000001 5 2 6 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_45489_933_1261_- FIG00000001 8 3 9 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_45502_990_1261_- FIG00092649 69 10 69 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_45520_971_1260_- FIG00138258 16 4 17 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_45546_120_878_- FIG00000088 200 30 200 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_45594_383_853_- FIG00001298 90 16 91 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_45594_966_1259_- FIG00000086 48 8 49 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_45613_1009_1259_- FIG00001505 10 4 11 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_45641_54_803_+ FIG00000594 74 14 76 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_45642_132_446_- FIG00132726 6 2 7 PTS system, fructose-specific IIB component (EC 2.7.1.69) Fructose utilization 1 T2D_unique_45657_621_941_- FIG00126843 15 5 17 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_45659_1_258_- FIG00001469 24 6 25 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_45668_1_325_- FIG00079822 11 3 13 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_45769_981_1256_- FIG00000156 27 5 28 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_45783_897_1256_- FIG00126843 50 8 51 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_45834_969_1255_+ FIG00554193 10 4 11 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_45845_1_997_+ FIG00000404 171 28 172 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_45855_83_451_- FIG00021347 8 4 9 Death on curing protein, Doc toxin Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_45874_1_920_- FIG00002992 78 24 153 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_45874_992_1255_- FIG00002992 50 9 50 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_45899_1023_1254_+ FIG00016303 41 6 42 Hyaluronan synthase (EC 2.4.1.212) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_45907_746_889_- FIG00002328 31 5 31 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_45940_1_1054_+ FIG00002020 99 20 100 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_45981_173_985_- FIG00002049 8 7 12 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_45981_1011_1253_- FIG00451095 21 5 23 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_45982_239_634_+ FIG00000764 10 3 12 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_45983_1019_1253_+ FIG00000038 12 3 13 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_46016_566_793_+ FIG00004470 7 3 8 VapB protein (antitoxin to VapC) Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_46036_941_1252_- FIG01266244 26 6 27 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_46039_998_1252_- FIG00001548 70 10 70 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_46068_974_1228_- FIG00000494 7 2 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_46082_917_1251_- FIG00001134 60 9 61 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_unique_46108_1_128_- FIG00018396 7 3 8 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_46142_1029_1250_+ FIG00002803 57 8 57 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_46172_277_717_- FIG00000166 41 11 42 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_46172_744_926_- FIG00000409 5 2 7 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_unique_46172_984_1250_- FIG00000182 61 9 61 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_46176_1_1037_+ FIG00080955 284 40 284 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_46178_1_447_+ FIG00001076 99 16 99 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_46178_558_782_+ FIG00038461 55 9 55 Putative deoxyribonuclease YjjV Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_46211_1_248_- FIG00000614 6 3 8 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_unique_46219_865_1032_+ FIG00003555 7 2 8 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_46219_1071_1232_+ FIG00003555 10 4 12 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_46248_152_1003_+ FIG00016110 166 31 167 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_46262_1_1013_+ FIG00000287 8 2 10 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_46293_1_665_- FIG00001548 82 11 83 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_46294_515_994_- FIG00136692 29 8 30 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_46314_1_547_+ FIG00011114 93 18 94 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_46325_1_539_+ FIG01290653 11 8 15 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_46355_964_1247_- FIG00001203 15 4 17 Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_46369_965_1247_- FIG00000114 34 6 36 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_46377_1087_1246_- FIG00018536 12 2 13 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_46398_1_171_+ FIG01304270 29 5 29 L,D-transpeptidase ErfK Peptidoglycan Crosslinking of Peptide Stems 1 T2D_unique_46404_225_536_+ FIG00000276 67 11 67 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_unique_46427_237_989_- FIG00085033 205 30 205 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_46427_995_1246_- FIG00085033 63 9 63 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_46440_365_1057_+ FIG00000948 52 14 53 Poly(A) polymerase (EC 2.7.7.19) Polyadenylation bacterial 2 T2D_unique_46469_1080_1245_+ FIG00041038 19 4 20 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_46483_1_454_- FIG00002914 4 2 6 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_46509_201_860_- FIG00136866 21 8 25 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_46517_1096_1244_+ FIG00009682 31 5 31 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_46527_1005_1244_+ FIG00000304 5 3 6 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_46607_1010_1243_+ FIG00846773 29 5 30 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_46636_1_156_+ FIG00049433 14 3 15 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_46642_96_497_- FIG00000594 98 14 101 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_46651_1_1231_+ FIG00001548 60 12 62 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_46656_1_467_- FIG01956356 10 4 11 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_46723_945_1241_- FIG00000069 3 2 4 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_46741_81_767_- FIG00139238 40 8 44 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_46748_1_209_- FIG00002560 6 2 7 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_46760_699_1025_+ FIG00127025 44 7 45 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_46789_527_1039_+ FIG00561498 49 9 51 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_46816_1008_1239_+ FIG00000088 26 5 27 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_46823_272_961_- FIG00000803 10 7 21 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_unique_46826_1048_1239_- FIG00623809 12 3 13 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_46836_1_308_+ FIG00000397 6 3 9 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_46836_361_1008_+ FIG00000985 36 8 38 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_46875_1028_1239_- FIG00001039 50 7 50 Ribonucleotide reduction protein NrdI Ribonucleotide reduction 1 T2D_unique_46903_664_1062_+ FIG00081563 82 12 83 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_46903_1086_1238_+ FIG00081563 31 5 31 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_46907_939_1238_- FIG00000376 7 4 8 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_46918_1_465_- FIG00001818 46 12 48 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_46929_1021_1238_+ FIG00001882 4 2 6 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_46968_1_455_- FIG00003580 7 4 8 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_46975_199_1014_+ FIG01260980 7 5 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_46982_1_152_- FIG00000098 5 2 7 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_46988_1_225_+ FIG00001235 27 7 29 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (EC 3.1.1.-) Capsular heptose biosynthesis 1 T2D_unique_47018_971_1236_- FIG00002194 17 4 18 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_47027_1_666_- FIG00000659 38 11 39 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_47028_1_173_+ FIG00138258 5 3 6 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_47045_1_936_- FIG00000243 56 13 58 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_47059_919_1236_- FIG01260980 19 7 20 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_47060_992_1236_- FIG00000709 31 5 32 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) Periplasmic disulfide interchange 1 T2D_unique_47066_1_273_+ FIG00001548 14 3 15 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_47116_9_224_+ FIG00029916 55 8 55 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_47126_1_163_- FIG00132770 26 5 27 Prephenate and/or arogenate dehydrogenase (unknown specificity) (EC 1.3.1.12)(EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_47126_974_1234_- FIG00000387 50 9 51 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_47129_1_521_- FIG00012267 5 2 6 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_47140_1_403_- FIG00014596 10 3 11 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_47140_957_1234_- FIG00000933 30 7 32 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_unique_47180_1_251_+ FIG00000053 30 5 31 LSU ribosomal protein L33p Ribosome LSU bacterial 9 T2D_unique_47184_8_166_+ FIG00000402 11 3 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_47189_333_560_+ FIG00005595 58 8 58 Copper chaperone Copper homeostasis 12 T2D_unique_47234_1_241_+ FIG00000372 9 2 11 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_47267_1_225_+ FIG00011115 54 8 54 PTS system, cellobiose-specific IIA component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_47305_1_886_- FIG00000555 33 10 36 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_47306_1_484_+ FIG00000899 81 13 83 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_47309_878_1232_- FIG00000182 46 8 47 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_47310_1_330_- FIG00018699 69 11 70 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_47311_1061_1232_+ FIG00018865 23 6 24 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_47314_993_1232_- FIG00000156 10 3 12 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_47315_1063_1232_+ FIG00000552 15 2 15 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_47384_1_190_+ FIG00132617 14 3 15 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_47444_1_452_- FIG00719736 21 7 23 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_47446_103_606_- FIG00000288 73 13 74 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_47469_955_1229_- FIG00000001 44 7 44 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_47472_1_450_+ FIG00000036 109 17 109 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_47477_1050_1229_+ FIG00023943 3 3 4 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_47522_1_449_- FIG00004413 29 8 30 Pantothenate kinase type II, eukaryotic (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_47534_1017_1228_+ FIG00036320 11 2 12 Alpha-1,4-N-acetylgalactosamine transferase PglJ (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_47550_1_781_- FIG00000333 45 11 47 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_47558_1_170_- FIG00001518 42 6 42 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_47560_173_565_- FIG00022031 101 16 101 L-fucose mutarotase L-fucose utilization 1 T2D_unique_47583_1_632_- FIG00143531 16 7 17 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_unique_47606_1_476_- FIG00000477 44 9 46 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_47654_382_927_- FIG01304229 16 4 18 MSM (multiple sugar metabolism) operon regulatory protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_47671_453_848_- FIG00000402 21 4 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_47678_1_853_- FIG00002066 13 7 15 Cytoplasmic alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_47688_753_1225_- FIG00133034 37 7 39 Excinuclease ABC subunit A paralog of unknown function DNA repair, UvrABC system 1 T2D_unique_47696_1_1218_+ FIG00048014 70 17 76 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_47707_462_1046_+ FIG00000584 136 21 137 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_47731_983_1225_- FIG00002803 54 8 55 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_47766_1_660_- FIG00024073 79 13 88 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_47779_696_1052_+ FIG00024401 27 6 29 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_47780_1_215_+ FIG00000194 25 5 27 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_47787_271_519_+ FIG00000101 28 5 29 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_47788_468_890_- FIG00000001 87 13 88 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_47864_1_878_- FIG00012683 36 12 39 NLP/P60 family protein CBSS-393121.3.peg.2760 1 T2D_unique_47864_959_1222_- FIG00012683 4 3 5 NLP/P60 family protein CBSS-393121.3.peg.2760 1 T2D_unique_47877_1_336_+ FIG00000838 6 3 7 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_47880_132_269_+ FIG00010310 22 4 23 ATP-dependent DNA helicase pcrA (EC 3.6.1.-) CBSS-393121.3.peg.1913 1 T2D_unique_47903_1_262_+ FIG00011622 23 5 24 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_47926_1_1001_+ FIG00001824 41 12 43 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_47935_994_1149_- FIG00229199 7 2 8 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_47939_933_1221_- FIG00000477 6 2 8 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_47957_690_860_+ FIG00016555 4 2 5 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_47966_1_790_+ FIG00002194 214 31 214 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_47995_478_900_- FIG00075702 44 9 45 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_47995_939_1221_- FIG00075702 39 7 40 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_47997_1_322_+ FIG01260980 15 4 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_48001_1_1007_+ FIG01260980 283 40 283 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_48001_1010_1220_+ FIG01260980 58 8 58 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_48006_163_600_+ FIG00000542 61 13 62 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_48007_375_650_+ FIG00001440 17 3 19 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_48030_912_1220_- FIG00000212 12 3 14 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_48070_978_1220_- FIG01260980 45 7 45 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_48086_1_258_- FIG00007960 67 10 67 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_48091_605_1033_+ FIG00022976 22 6 24 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_48091_1069_1219_+ FIG00022976 5 2 6 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_48121_1_1053_- FIG00002416 56 14 60 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_48125_1_226_- FIG00000430 19 4 20 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_unique_48131_1_252_+ FIG01303978 4 3 5 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) AmpD Recycling of Peptidoglycan Amino Acids 1 T2D_unique_48134_1_1183_+ FIG00000039 133 23 135 Translation elongation factor Tu Translation elongation factors bacterial 1.1 T2D_unique_48139_996_1219_- FIG01955844 55 9 55 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_48161_1072_1218_+ FIG01260980 5 2 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_48162_1_867_- FIG00000494 221 33 222 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_48217_1_197_- FIG00000704 36 6 36 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_48218_348_1175_+ FIG00000590 3 7 19 NAD synthetase (EC 6.3.1.5) NAD and NADP cofactor biosynthesis global E T2D_unique_48230_242_1015_+ FIG00050243 213 30 213 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_48250_463_756_- FIG00000298 9 3 11 GTP-binding protein EngB Universal GTPases 2 T2D_unique_48317_480_956_+ FIG00018699 3 2 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_48327_1029_1215_+ FIG00134486 27 5 27 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_48336_257_1138_+ FIG00018457 7 5 9 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_48356_552_1022_+ FIG00001170 130 17 130 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_unique_48356_1076_1215_+ FIG00001170 28 5 28 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_unique_48368_809_1102_+ FIG00041038 40 7 42 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_48382_1_303_- FIG00050854 7 5 27 Tricarboxylate transport protein TctC Tricarboxylate transport system 1.x T2D_unique_48423_1001_1214_+ FIG00002020 13 4 14 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_48440_454_1011_+ FIG00000130 150 22 150 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_48447_714_1082_+ FIG00000376 66 11 66 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_48453_1_209_+ FIG00000084 55 8 55 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_48471_1051_1213_- FIG01260980 6 2 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_48474_1_666_- FIG00004026 197 26 197 Tellurite resistance protein TehB Tellurite resistance: Chromosomal determinants 1.1 T2D_unique_48482_1_1037_+ FIG00000372 42 10 44 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_48493_793_1056_+ FIG00088522 10 4 12 Melibiose carrier protein, Na+/melibiose symporter Melibiose Utilization A T2D_unique_48501_1043_1213_+ FIG00132617 25 5 27 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_48602_235_768_- FIG00000453 136 20 137 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_48602_936_1115_- FIG00000453 26 4 27 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_48639_1054_1211_+ FIG00006463 9 3 10 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_48678_179_799_- FIG00000510 166 23 166 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_48702_1065_1210_+ FIG00006235 9 2 10 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_unique_48721_923_1210_- FIG00087623 53 8 54 Glycosyltransferase LafA, responsible for the formation of Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_48724_204_1001_+ FIG00001406 158 27 159 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_48729_998_1209_+ FIG00003751 7 4 9 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_48736_839_1093_- FIG00945384 4 3 5 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_48740_1_275_- FIG00130344 7 3 8 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_48741_1007_1209_+ FIG00623809 16 4 17 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_48805_1009_1208_+ FIG00000241 31 6 32 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_48823_1_909_+ FIG00000834 19 3 21 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_48840_747_1013_+ FIG00000985 38 6 39 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_48848_790_1023_+ FIG00018865 31 6 32 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_48871_984_1207_- FIG00009194 48 7 48 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_48902_827_1033_+ FIG00000132 37 6 39 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_48902_1045_1206_+ FIG00000132 15 3 16 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_49012_207_818_+ FIG00019251 11 4 13 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_49014_587_955_- FIG00000242 46 8 47 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_49014_964_1205_- FIG00000242 24 4 25 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_49015_1_447_+ FIG00000103 13 3 14 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_49019_346_780_+ FIG00050854 24 5 26 Tricarboxylate transport protein TctC Tricarboxylate transport system 1.x T2D_unique_49049_1_341_- FIG00076542 14 4 15 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_49093_743_1015_+ FIG00029916 65 10 65 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_49093_1030_1204_+ FIG00029916 43 7 43 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_49094_987_1204_- FIG00041038 47 7 48 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_49140_994_1149_- FIG00000380 14 4 15 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_49145_1_289_- FIG00014849 7 3 8 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_49174_1_1032_+ FIG00140555 88 23 94 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_49203_157_789_- FIG00000396 27 11 33 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_49207_1_1077_+ FIG00000402 87 18 90 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_49212_1_663_+ FIG00715305 7 3 8 Formyl-coenzyme A transferase (EC 2.8.3.16) Glycolate, glyoxylate interconversions ? T2D_unique_49221_869_1202_- FIG00000116 27 5 28 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_49267_1_887_- FIG00018457 37 12 42 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_49279_1_228_+ FIG00003520 4 3 5 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_49296_1_654_+ FIG00000812 101 20 104 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_49310_1_275_- FIG00036224 17 6 18 Sialidase (EC 3.2.1.18) Sialic Acid Metabolism 1.x T2D_unique_49349_962_1200_- FIG00623809 43 7 44 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_49355_1_249_- FIG00005705 33 6 33 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_unique_49355_306_881_- FIG00002011 130 21 131 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_unique_49367_1055_1199_+ FIG00000085 8 2 9 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_49376_1_1007_+ FIG00561498 45 11 48 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_49441_827_967_- FIG00000032 37 5 37 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_49441_991_1198_- FIG00000032 49 8 49 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_49458_950_1198_- FIG00000268 53 8 53 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_49460_680_847_- FIG00000720 5 2 7 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_49461_958_1198_- FIG00020897 37 6 38 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_49463_925_1198_+ FIG00000298 11 4 13 GTP-binding protein EngB Universal GTPases 2 T2D_unique_49511_1_149_+ FIG00103625 27 5 27 Predicted transcriptional regulator of cysteine synthase, Rrf2 family Rrf2 family transcriptional regulators 4 T2D_unique_49526_667_894_+ FIG00001611 64 9 64 Protein of unknown function DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_49533_851_1197_- FIG00001069 46 8 47 Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_49590_1_414_- FIG00011468 25 6 26 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_49597_584_928_- FIG00000168 49 11 50 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_49626_262_984_- FIG00018536 41 12 44 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_49645_1_929_- FIG00003788 20 7 26 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_49651_1_322_+ FIG00000184 20 6 22 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_49667_191_610_+ FIG00229216 22 7 24 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_49707_895_1195_- FIG00094401 10 3 11 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_49720_1_621_+ FIG00048014 143 23 143 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_49720_827_1012_+ FIG00009889 37 6 38 Mevalonate kinase (EC 2.7.1.36) Isoprenoid Biosynthesis 2.x T2D_unique_49720_1051_1195_+ FIG00009889 35 5 35 Mevalonate kinase (EC 2.7.1.36) Isoprenoid Biosynthesis 2.x T2D_unique_49742_1067_1194_+ FIG01954097 7 2 8 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_49744_354_866_+ FIG00001903 5 2 7 Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) Glutaredoxins 1 T2D_unique_49791_1_1006_+ FIG00023542 8 6 11 4-hydroxyproline epimerase (EC 5.1.1.8) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_49801_601_774_+ FIG00003535 10 2 11 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_49857_663_944_- FIG00004169 21 5 21 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_49857_974_1193_- FIG00004169 29 5 30 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_49858_1_437_- FIG00006463 33 8 35 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_49860_1_195_- FIG00026137 14 3 16 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_49868_1_731_- FIG00067248 13 6 15 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_49883_696_968_- FIG00003439 15 3 16 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_49883_974_1192_- FIG00003439 4 2 6 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_49884_822_1192_+ FIG00003439 10 3 12 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_49885_925_1192_- FIG00000449 11 3 12 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_49895_1_290_- FIG00023943 26 7 28 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_49913_822_1192_- FIG00005727 5 2 6 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_49915_959_1192_- FIG00000897 3 2 4 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_49952_964_1191_- FIG00003845 9 2 10 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_49981_1_349_- FIG00000601 7 4 30 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_50015_534_1034_+ FIG00016514 7 3 9 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_50026_1_334_+ FIG00000128 39 8 40 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_50029_1_546_+ FIG00000315 35 7 36 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_50036_40_357_- FIG01955919 8 4 11 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_50050_535_900_- FIG00033705 78 13 78 Biotin synthesis protein BioC Biotin biosynthesis 1X T2D_unique_50050_966_1190_- FIG00033705 43 6 43 Biotin synthesis protein BioC Biotin biosynthesis 1X T2D_unique_50092_1_856_- FIG00085033 55 15 58 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_50106_1_269_+ FIG00051439 33 6 34 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_50130_1_699_+ FIG00005172 27 8 29 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_50136_1_684_+ FIG00000047 184 27 185 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_50159_839_1015_+ FIG00018396 7 3 8 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_50161_933_1188_- FIG00002541 3 3 5 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_50163_1_1014_+ FIG00139508 269 38 269 periplasmic fructose-binding protein component of signal transduction system LevQ Fructose and Mannose Inducible PTS 2 T2D_unique_50183_1_908_+ FIG00001635 41 12 44 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_50186_1_548_+ FIG00451095 15 4 16 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_50236_956_1187_- FIG00120441 5 2 6 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_50288_1_622_- FIG00000304 34 10 36 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_50296_793_1186_- FIG01260980 14 3 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_50330_1_495_+ FIG00034293 4 3 6 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_50343_1_229_+ FIG00002974 23 4 24 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_50343_663_1025_+ FIG00000578 38 7 39 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_50343_1043_1185_+ FIG00000578 9 3 10 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_50344_385_852_- FIG00004764 101 16 102 Ammonium transporter Ammonia assimilation 1 T2D_unique_50344_935_1185_- FIG00005111 53 7 53 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_unique_50352_604_960_- FIG01007502 10 3 12 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_50361_384_1118_+ FIG00007658 32 10 34 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_50363_905_1185_- FIG00046929 51 8 52 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_50397_928_1185_- FIG00076542 7 2 9 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_50440_441_941_+ FIG01304992 54 9 55 CRISPR-associated protein, Cas6 CRISPR-associated cluster 1 T2D_unique_50443_849_1070_+ FIG00031250 9 3 11 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_50461_1_534_+ FIG00000112 14 4 15 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_50530_1_295_+ FIG00000166 13 7 15 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_50548_494_1009_+ FIG00035634 140 20 140 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_50548_1039_1183_+ FIG00035634 28 5 29 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_50565_759_1040_+ FIG00000279 7 3 8 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_50568_958_1182_+ FIG00004100 7 2 7 Cold shock protein CspA Cold shock, CspA family of proteins 1 T2D_unique_50583_1_758_+ FIG00000097 32 7 34 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_50583_781_1002_+ FIG00000401 9 3 11 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_50583_1050_1182_+ FIG00000401 6 2 8 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_50590_130_894_- FIG00006463 13 5 15 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_50590_921_1182_- FIG00006463 3 2 4 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_50612_1_564_- FIG00000032 39 10 42 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_50615_1_647_+ FIG00022568 26 9 27 Phosphonate ABC transporter ATP-binding protein (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_50645_1_1003_+ FIG00073301 72 16 74 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_50713_1_828_- FIG00073301 177 29 178 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_50740_79_732_- FIG01955850 67 18 69 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_50797_1_435_- FIG00000338 111 16 111 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_50797_844_1179_- FIG00000348 22 4 25 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_unique_50832_1_1021_+ FIG00000185 129 25 130 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_50901_1_650_+ FIG00139238 80 17 82 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_50935_921_1177_- FIG00001670 5 3 10 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_50937_1_564_- FIG00001088 152 22 152 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_51015_969_1176_- FIG00003270 5 2 9 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_unique_51047_370_1176_- FIG00598409 33 9 39 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_51052_905_1176_- FIG00000038 30 5 31 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_51075_1_630_+ FIG00000140 133 21 134 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_51099_275_1018_+ FIG00000128 54 11 56 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_51111_335_1175_+ FIG00006889 20 4 22 L-rhamnose isomerase (EC 5.3.1.14) L-rhamnose utilization 1 T2D_unique_51147_117_1031_+ FIG00089870 241 35 241 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_unique_51154_1_556_+ FIG00001385 11 6 12 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_51164_1027_1174_+ FIG00014849 29 5 29 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_51172_499_1098_+ FIG01260980 5 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_51186_166_861_+ FIG00003955 193 27 193 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_51186_888_1106_+ FIG00001960 19 4 20 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_51223_1_419_- FIG00005705 69 11 69 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_unique_51279_863_1003_+ FIG00148704 30 5 30 tRNA-dependent lipid II--L-alanine ligase tRNA-dependent amino acid transfers 1 T2D_unique_51371_719_1072_+ FIG01298521 70 11 70 Lipoteichoic acid synthase LtaS Type IIb Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_51374_1_371_+ FIG00000289 3 4 5 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_51380_921_1115_- FIG00000001 7 2 8 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_51382_1_879_- FIG00041137 10 3 12 Transmembrane component CbiQ of energizing module of cobalt ECF transporter ECF class transporters 345678 T2D_unique_51426_960_1121_- FIG00002148 8 2 9 Aspartate carbamoyltransferase regulatory chain (PyrI) De Novo Pyrimidine Synthesis 1 T2D_unique_51431_1_320_+ FIG00008941 34 7 35 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_51461_1_264_+ FIG00030688 14 5 15 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_51471_15_323_- FIG00013339 3 3 4 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_51475_1_843_+ FIG00000070 40 15 41 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_51476_951_1170_- FIG00007059 9 2 10 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_51504_952_1169_- FIG00000452 42 6 42 Chemotaxis protein methyltransferase CheR (EC 2.1.1.80) Bacterial Chemotaxis 9 T2D_unique_51509_1_889_- FIG00561498 3 4 5 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_51510_972_1169_- FIG00134167 18 5 19 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_51543_197_817_- FIG00005172 5 2 6 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_51559_1_508_+ FIG00002463 14 3 15 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_51567_849_1169_- FIG00018699 3 2 4 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_51589_1_224_- FIG00067248 9 2 10 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_51602_1_1009_+ FIG00000494 55 15 58 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_51631_1_799_+ FIG00044622 112 19 114 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_51639_969_1167_- FIG00005587 6 2 7 Transcriptional regulator of rhamnose utilization, AraC family L-rhamnose utilization 1 T2D_unique_51685_751_981_+ FIG00000897 10 3 11 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_51720_1_363_+ FIG00001635 4 3 7 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_51724_1_413_- FIG00006092 7 3 8 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_51734_1_519_- FIG00000112 37 9 39 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_51734_534_908_- FIG00000017 33 7 35 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_51747_970_1166_- FIG00008490 36 5 37 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_51755_418_1005_+ FIG00000376 32 10 33 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_51767_679_1134_+ FIG00000578 8 2 10 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_51776_959_1165_- FIG00000145 20 6 21 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_51807_136_408_+ FIG00023268 14 5 16 DNA-binding protein HU-beta DNA structural proteins, bacterial 1.1100 T2D_unique_51824_1_833_+ FIG00005172 148 26 149 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_51832_1_705_- FIG00051439 109 19 111 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_51853_1_668_- FIG00026137 159 24 160 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_51910_1_357_+ FIG00000243 82 13 82 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_51920_987_1164_- FIG00340853 32 5 32 Oxalyl-CoA decarboxylase (EC 4.1.1.8) Glycolate, glyoxylate interconversions ? T2D_unique_51937_991_1163_- FIG00000036 5 2 6 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_51946_1_237_- FIG00004453 56 9 56 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_51946_301_993_- FIG00000116 189 27 189 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_51970_1_927_- FIG00028203 142 27 143 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_51994_205_1029_+ FIG00000517 53 15 54 Iron-sulfur cluster-binding protein Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_52061_1_356_- FIG00001882 31 9 32 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_52077_881_1027_+ FIG00000456 8 2 10 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_52128_1_279_+ FIG00001670 62 10 62 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_52151_1_560_- FIG00000397 133 22 134 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_52179_243_632_- FIG00000967 17 5 18 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_unique_52179_786_1061_- FIG00000043 24 5 25 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_52199_1_787_- FIG00000747 10 6 12 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_52246_1_707_- FIG00000578 101 20 102 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_52262_1030_1159_+ FIG00440770 23 4 23 Glutathione peroxidase family protein Glutathione: Redox cycle 1 T2D_unique_52278_1_1014_+ FIG00007137 75 14 77 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_52284_594_962_- FIG00109688 92 13 92 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_52304_1_1001_+ FIG00001022 227 35 227 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_52348_1_863_- FIG00945384 178 28 179 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_52349_1_345_- FIG00000520 22 6 23 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_52350_1_572_- FIG00001893 21 5 22 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_52372_957_1157_- FIG00003715 7 2 7 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_52413_983_1157_- FIG00003129 38 6 38 Galactose operon repressor, GalR-LacI family of transcriptional regulators Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_52416_650_1157_+ FIG00000557 16 4 18 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_52423_1_205_+ FIG00451095 28 5 29 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_52444_1_233_+ FIG00002799 5 2 9 Phosphoheptose isomerase 1 (EC 5.3.1.-) Capsular heptose biosynthesis 1 T2D_unique_52490_1_162_+ FIG00001555 38 6 38 Cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Putative oxidase COG2907 9 T2D_unique_52502_995_1155_- FIG00001469 27 5 28 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_52547_1006_1155_+ FIG00006465 6 2 7 Nickel transport ATP-binding protein NikD (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_52583_84_422_+ FIG00000279 8 3 9 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_52631_1_881_- FIG00000025 5 3 9 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_52634_995_1153_- FIG00052605 8 2 9 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_52640_259_1080_+ FIG00000235 168 25 168 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_52650_927_1153_- FIG00000510 23 5 24 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_52661_402_1025_+ FIG00000080 62 14 64 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_52662_1_432_- FIG00001548 9 4 10 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_52688_1_374_- FIG00038920 3 2 4 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_52705_964_1152_- FIG01304636 38 6 39 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_52727_1_129_+ FIG00000477 5 2 6 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_52748_1_993_- FIG00001712 58 17 61 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_52751_1_305_- FIG00000897 74 12 74 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_52751_855_1034_+ FIG00437351 31 5 31 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_unique_52752_1_328_- FIG00098273 83 12 83 Glycine/sarcosine/betaine reductase component C chain 2 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_52752_949_1152_- FIG00107349 33 6 34 Glycine/sarcosine/betaine reductase component C chain 1 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_52826_1_135_+ FIG00085033 10 2 11 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_52834_681_1130_+ FIG00001469 16 5 17 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_52838_33_290_+ FIG00001712 13 4 15 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_52895_1_1150_- FIG00051439 192 31 195 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_52896_920_1150_- FIG00052730 34 5 34 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_52921_282_656_+ FIG01955011 89 13 89 Hypothetical protein DUF454 Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_52921_715_1002_+ FIG01010650 72 11 72 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_52928_647_1102_+ FIG00000838 6 2 8 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_52932_1_188_+ FIG00000309 50 7 50 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_52936_1_456_+ FIG00014849 119 18 119 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_52958_405_1016_+ FIG00048014 154 23 154 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_52990_1021_1149_+ FIG00000720 13 3 14 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_53050_1_1148_+ FIG00023369 21 16 39 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_53117_1_956_- FIG00005924 97 21 99 Excinuclease ABC subunit A paralog in greater Bacteroides group DNA repair, UvrABC system 1 T2D_unique_53118_1_1003_+ FIG00031250 123 23 125 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_53128_1_1016_+ FIG00041038 21 12 23 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_53164_1_425_+ FIG00019251 66 13 67 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_53192_505_954_- FIG01016270 29 7 32 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_53192_966_1146_- FIG01016270 11 3 12 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_53215_899_1146_- FIG00000402 7 4 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_53224_282_659_- FIG00000203 103 15 103 SSU ribosomal protein S12p (S23e) Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_53224_968_1146_- FIG00000242 6 2 9 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_53235_950_1146_- FIG01260980 12 3 13 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_53240_582_1031_+ FIG00017190 30 7 32 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_53241_955_1146_- FIG00007328 32 5 33 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_53250_1_412_+ FIG00005860 7 2 8 SusD, outer membrane protein Cellulosome 1.x T2D_unique_53346_158_448_- FIG00000455 11 3 12 Malate dehydrogenase (EC 1.1.1.37) Serine-glyoxylate cycle 1 T2D_unique_53352_936_1144_- FIG00005860 39 6 41 SusD, outer membrane protein Cellulosome 1.x T2D_unique_53363_972_1144_+ FIG00000065 23 4 24 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_53365_1_257_+ FIG00001106 41 7 41 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_53373_568_1144_- FIG00028476 85 14 86 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_53377_32_949_+ FIG00010508 114 21 115 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_53406_696_1013_+ FIG00013609 4 2 5 DNA-entry nuclease (Competence-specific nuclease) (EC 3.1.30.-) Gram Positive Competence 3100 T2D_unique_53413_1_326_+ FIG01260980 14 5 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_53446_1_228_+ FIG01260980 38 7 39 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_53458_1_576_- FIG00001559 146 21 146 N-formylglutamate deformylase (EC 3.5.1.68) Histidine Degradation 1.100 T2D_unique_53462_1_1018_+ FIG00088522 192 32 193 Melibiose carrier protein, Na+/melibiose symporter Melibiose Utilization A T2D_unique_53493_1_159_+ FIG00026595 10 2 11 ABC transporter membrane-spanning permease, Pep export, Vex3 Streptococcus pneumoniae Vancomycin Tolerance Locus 3 T2D_unique_53560_1_924_- FIG00003506 257 36 257 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_53560_927_1141_- FIG00003506 16 3 20 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_53600_1_1001_+ FIG00019251 87 19 88 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_53615_1_1014_+ FIG00001548 284 40 284 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_53636_957_1140_- FIG00001834 3 2 4 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_53643_1_262_+ FIG00846773 63 9 63 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_53709_1_171_+ FIG00003472 13 3 15 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_53746_1_299_+ FIG00049433 3 2 4 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_53781_963_1139_- FIG00006551 26 5 26 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_53956_9_461_- FIG00000205 29 8 30 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_54022_491_907_- FIG00000645 43 8 45 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_54036_768_944_- FIG00000261 9 3 10 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_54048_1_322_+ FIG00001366 8 3 9 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_54053_1_633_- FIG00045144 66 16 67 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_54053_636_998_- FIG00006151 37 8 39 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_54056_1_513_- FIG00006463 118 19 118 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_54070_1_359_- FIG00000151 83 12 84 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_54101_969_1134_- FIG00132994 34 5 35 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_54124_332_1134_- FIG00002742 118 20 119 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_54145_760_1017_+ FIG00000337 10 4 11 Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_unique_54168_969_1133_- FIG00000532 6 2 7 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_54186_752_1027_+ FIG00132586 10 4 11 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_54213_540_1055_+ FIG00034392 122 18 123 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_54228_1_946_- FIG01260980 9 9 13 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_54228_976_1133_- FIG01260980 3 3 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_54241_1_204_- FIG00000425 15 3 16 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_54242_1_344_- FIG00000241 32 7 33 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_54259_1_438_+ FIG00007960 14 4 16 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_54313_1_231_+ FIG00004078 19 4 20 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_54373_526_1002_+ FIG00008907 18 4 19 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_54402_1_401_+ FIG00001020 78 14 79 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_54404_708_1022_+ FIG00002354 28 7 30 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_54412_1_339_+ FIG00002300 12 2 13 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_54463_386_1130_+ FIG00132617 4 4 7 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_54466_1_456_+ FIG00002968 9 4 11 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_54472_1_729_- FIG00846773 4 4 7 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_54485_394_831_- FIG00022031 7 4 10 L-fucose mutarotase L-fucose utilization 1 T2D_unique_54486_966_1130_- FIG00066643 17 3 18 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_54496_1_193_- FIG00024401 13 3 14 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_54496_996_1129_- FIG00000243 7 2 8 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_54514_1_739_+ FIG00031250 7 6 10 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_54558_996_1128_+ FIG00000234 10 3 10 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_54618_590_1030_+ FIG00020185 60 9 61 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_54656_436_987_- FIG00000456 38 9 40 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_54685_970_1127_- FIG00000494 9 2 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_54706_403_987_- FIG00031250 15 7 18 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_54753_1_250_- FIG00000673 58 8 59 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_unique_54753_332_925_- FIG00000314 146 22 146 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_54778_917_1126_- FIG00013554 20 3 21 Stage III sporulation protein AB Sporulation Cluster III A 1.x T2D_unique_54781_1_1126_+ FIG00000139 263 38 264 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_54806_983_1125_+ FIG00003460 3 2 4 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_54857_866_1125_+ FIG00018699 25 5 27 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_54860_1_522_- FIG00000376 60 11 61 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_54862_1_347_- FIG00093180 84 13 84 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_54884_1_1124_+ FIG00002130 42 14 44 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_54903_71_949_- FIG00001166 67 11 69 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_55001_1_428_+ FIG00023946 120 16 120 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_55001_440_745_+ FIG00004334 5 3 6 CRISPR-associated protein Cas2 CRISPRs 1 T2D_unique_55003_1_183_- FIG00000825 17 4 18 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_55008_1_407_+ FIG00008572 5 3 6 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_55015_1_357_- FIG01312219 38 8 39 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_unique_55015_375_905_- FIG00473043 18 6 21 Similar to CDP-glucose 4,6-dehydratase (EC 4.2.1.45) Acetoin, butanediol metabolism 5 T2D_unique_55020_1_905_- FIG00143531 139 26 141 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_unique_55023_1_395_- FIG00000453 86 14 87 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_55038_968_1122_- FIG00130344 30 5 31 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_55055_1_689_- FIG00003076 95 18 97 Lactam utilization protein LamB EC699-706 1 T2D_unique_55055_704_1042_- FIG00000420 48 8 49 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_55088_1_750_- FIG00000415 149 24 150 Ribose 5-phosphate isomerase A (EC 5.3.1.6) Glycolate, glyoxylate interconversions ? T2D_unique_55090_960_1122_- FIG00011537 7 3 9 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_55092_1_574_- FIG00001011 43 10 45 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_55095_1_779_- FIG00073301 10 4 12 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_55105_171_434_- FIG00000314 45 7 46 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_55162_619_1011_+ FIG00133515 12 3 14 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_55170_689_1030_+ FIG00001670 66 11 67 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_55196_1_763_- FIG00554193 38 12 40 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_55196_780_1121_- FIG00054459 14 3 15 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_55289_1_326_+ FIG00016110 66 11 66 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_55313_1_136_+ FIG00049915 26 5 27 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_55314_212_1119_+ FIG00000560 134 26 137 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_55371_960_1118_- FIG00043476 30 4 31 preQ1-regulated inosine-uridine nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_55380_1_735_- FIG00000184 196 29 197 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_55392_1_930_- FIG00001882 234 35 234 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_55409_209_1036_+ FIG00000337 24 6 26 Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_unique_55423_31_303_- FIG00614545 68 10 68 Acylphosphate phosphohydrolase (EC 3.6.1.7), putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_55434_1_363_+ FIG00000459 24 5 26 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_55449_1_977_- FIG00000578 19 8 21 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_55459_1_383_- FIG00028476 13 8 15 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_55484_1_237_- FIG00000108 8 2 9 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_55491_1_416_+ FIG00945384 15 6 17 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_55499_1_350_+ FIG00000290 27 5 28 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_55511_1_960_- FIG00001712 90 15 91 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_55535_1_772_+ FIG00000396 3 3 5 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_55547_278_916_+ FIG01255877 6 7 11 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_55578_1_569_+ FIG00007079 28 7 29 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_55589_957_1116_+ FIG00047509 7 2 8 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_55593_1_618_- FIG00002968 4 3 7 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_55629_1_948_- FIG00000391 93 21 95 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_55629_984_1115_- FIG00000391 6 2 6 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_55635_1_561_- FIG00000402 67 15 68 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_55645_236_640_- FIG00007079 3 2 5 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_55698_264_968_+ FIG00003788 65 13 67 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_55722_1_1091_+ FIG00093180 38 9 40 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_55727_1_397_+ FIG00598409 101 16 101 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_55730_1_334_+ FIG00135554 8 3 9 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_55738_932_1114_- FIG00000328 9 4 10 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_55749_1_892_+ FIG00000717 84 21 86 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_55763_563_1012_+ FIG00000113 48 13 70 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_55782_1_568_+ FIG00006151 86 15 88 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_55816_1_1095_- FIG00002470 51 14 57 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_55831_213_1103_+ FIG00138258 209 31 210 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_55857_379_1017_+ FIG00046929 180 25 180 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_55859_5_487_+ FIG00000112 84 14 85 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_55896_255_725_+ FIG00001968 62 12 63 PTS system, mannose-specific IIB component (EC 2.7.1.69) Sialic Acid Metabolism 1.x T2D_unique_55932_1_1039_+ FIG00003251 137 24 138 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_55945_964_1111_- FIG00000323 7 3 8 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_55987_641_973_- FIG00001667 3 2 4 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_55993_1_344_- FIG00007514 5 4 7 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_55997_1_558_+ FIG00002110 164 22 164 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_55997_560_1000_+ FIG00002110 111 18 111 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_56007_1_257_- FIG00000298 60 9 60 GTP-binding protein EngB Universal GTPases 2 T2D_unique_56014_245_805_+ FIG00085740 17 7 19 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_56016_977_1110_- FIG00000080 18 4 18 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_56022_742_999_- FIG00000721 26 5 27 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_56111_609_983_- FIG00016663 16 4 17 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_56126_1_128_- FIG00006734 31 5 31 4-amino-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) acetyltrasferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_56144_33_1004_+ FIG00010508 201 30 203 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_56151_717_905_- FIG00000624 7 2 8 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_56199_1_818_+ FIG00000345 37 10 41 Ferrochelatase, protoheme ferro-lyase (EC 4.99.1.1) Biogenesis of c-type cytochromes 1.1 T2D_unique_56240_1_869_- FIG00018457 11 5 13 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_56265_500_904_- FIG00004502 5 2 7 5'-nucleotidase YjjG (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_56297_218_580_- FIG00091347 8 4 11 Pectin degradation protein KdgF Alginate metabolism 4.xx T2D_unique_56298_1_922_+ FIG00000380 59 12 64 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_56321_810_1107_+ FIG00000825 11 2 12 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_56331_1_405_- FIG00009194 102 15 103 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_56334_1_1036_+ FIG00026918 64 16 66 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_56359_512_982_- FIG00004014 45 9 47 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_56384_1_425_- FIG00002561 28 5 29 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_56397_95_697_+ FIG01304636 121 18 122 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_56426_528_671_+ FIG00001783 27 4 27 Diphosphomevalonate decarboxylase (EC 4.1.1.33) Isoprenoid Biosynthesis 2.x T2D_unique_56474_1_418_- FIG00074225 4 3 6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_56576_232_816_+ FIG00002718 49 13 50 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_56593_1_528_+ FIG00000440 47 9 49 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_unique_56609_1_461_- FIG00024546 51 8 52 Phosphonoacetaldehyde hydrolase (EC 3.11.1.1) Phosphonate metabolism 1 T2D_unique_56611_1_500_- FIG00000130 133 20 133 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_56619_1_835_+ FIG00000585 226 32 227 Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_56627_1_1045_+ FIG00074196 272 40 273 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_56647_1_135_- FIG00001577 28 5 28 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_56679_118_843_+ FIG01954097 103 19 106 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_56690_837_1102_- FIG00000532 12 3 13 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_56692_448_1102_+ FIG00000001 72 15 74 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_56707_103_972_- FIG00000527 10 8 13 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_56726_1_402_+ FIG01959019 103 14 103 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_unique_56726_414_656_+ FIG00004843 65 9 65 Protein YidD Cell Division Subsystem including YidCD 1 T2D_unique_56887_1_947_- FIG00009194 141 21 142 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_56902_1_720_+ FIG00000185 114 21 115 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_56902_733_1062_+ FIG00004170 30 6 31 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_56906_1_393_+ FIG01318398 102 15 102 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_56911_173_1027_+ FIG00134167 216 33 217 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_56925_1_866_- FIG00013156 44 13 46 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_56930_348_668_+ FIG00001054 24 5 25 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_56954_1_456_+ FIG00002354 124 18 124 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_57026_632_1009_+ FIG00057709 5 3 7 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_57028_1_560_+ FIG00003506 61 11 62 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_57055_234_839_- FIG00846773 5 3 7 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_57060_1_271_+ FIG00000376 40 6 41 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_57062_391_834_- FIG00001980 30 6 31 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_57087_1_314_- FIG00028461 40 9 41 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_57090_125_550_+ FIG00000251 110 16 110 Nucleoside diphosphate kinase (EC 2.7.4.6) Purine conversions 4.1118100 T2D_unique_57141_715_1062_- FIG00012746 52 8 54 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_57158_723_1097_+ FIG00007025 32 6 34 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_57209_1_763_+ FIG00000011 204 29 204 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_57209_775_1002_+ FIG00000494 9 3 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_57229_1_1034_+ FIG00000279 46 13 50 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_57262_182_355_+ FIG00002689 37 6 37 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_57277_1_683_- FIG00018699 9 4 11 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_57342_272_1006_+ FIG00000289 80 19 81 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_57374_1_214_+ FIG00084255 13 4 14 Stage III sporulation protein AC Sporulation Cluster III A 1.x T2D_unique_57433_872_1054_+ FIG00002541 29 4 30 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_57456_448_951_- FIG00000352 26 7 27 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_57484_963_1093_- FIG00025216 7 2 10 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_57497_1_711_- FIG00013525 48 12 50 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_unique_57593_383_925_- FIG00000355 137 21 137 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_57599_442_1059_+ FIG00002194 5 3 7 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_57680_917_1091_- FIG00008490 11 3 13 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_57691_1_711_+ FIG00021289 151 22 152 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_57702_1_1002_+ FIG00035893 17 9 42 Nickel ABC transporter, periplasmic nickel-binding protein NikA (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_57744_1_134_+ FIG00000173 22 4 25 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_57753_719_1057_+ FIG00000395 24 5 25 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_57771_1_313_+ FIG00067562 8 2 9 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_57785_959_1089_- FIG00000681 18 3 18 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_unique_57786_1_368_+ FIG00036997 11 4 12 Na(+)-translocating NADH-quinone reductase subunit C (EC 1.6.5.-) Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_57870_650_1088_+ FIG00132839 96 14 98 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_57918_1_318_+ FIG01010650 3 3 6 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_57919_1_735_+ FIG00049915 72 16 74 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_57956_586_846_- FIG00000023 51 9 51 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_unique_57982_1_496_+ FIG00075970 23 5 25 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_57990_1_1030_+ FIG00020576 10 7 15 Predicted nucleoside ABC transporter, ATP-binding component Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_58016_243_1031_+ FIG00047509 15 8 17 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_58126_328_1017_+ FIG00000838 58 14 62 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_58165_461_1085_+ FIG00000043 60 14 62 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_58172_1_389_- FIG00054459 40 8 41 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_58191_1_927_- FIG00034293 110 26 111 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_58205_159_599_+ FIG00000333 31 7 33 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_58213_902_1084_- FIG00129616 10 2 11 GTP-binding protein EngA Universal GTPases 2 T2D_unique_58225_1_492_- FIG00139238 112 17 112 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_58240_1_704_- FIG00001469 100 19 104 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_58270_712_1062_+ FIG00032749 25 6 28 Protein YicC CBSS-323097.3.peg.2594 1 T2D_unique_58278_401_910_- FIG00000491 139 20 139 Queuosine Biosynthesis QueC ATPase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_58279_1_191_- FIG00000645 3 2 4 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_58285_1_1064_+ FIG00000990 17 6 21 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_58319_808_1083_- FIG00002239 52 7 52 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_58354_764_1083_- FIG00001618 9 2 10 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_58356_856_1083_+ FIG00000235 6 2 7 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_58375_505_1005_+ FIG00019868 6 2 10 Maltose/maltodextrin ABC transporter, permease protein MalF Maltose and Maltodextrin Utilization 1.x T2D_unique_58438_215_1054_+ FIG01583289 87 18 89 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_58452_585_1082_+ FIG00018699 104 15 104 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_58509_938_1081_+ FIG00138018 10 3 10 Alpha-glucosidase SusB (EC 3.2.1.20) Cellulosome 1.x T2D_unique_58514_182_508_- FIG00023369 5 2 7 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_58536_1_275_- FIG00002947 68 10 69 Chemotaxis protein CheC -- inhibitor of MCP methylation Bacterial Chemotaxis 9 T2D_unique_58542_151_891_- FIG00014079 27 7 28 HipA protein Persister Cells 1 T2D_unique_58602_1_513_+ FIG00018699 19 7 20 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_58624_1_185_- FIG00000624 13 3 14 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_58635_521_1080_+ FIG00001452 6 4 7 Transcriptional repressor of the fructose operon, DeoR family Fructose utilization 1 T2D_unique_58638_1_199_- FIG00016110 41 8 41 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_58659_384_983_- FIG00000001 33 6 36 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_58678_101_1079_- FIG00003765 17 5 22 Low-affinity gluconate/H+ symporter GntU D-gluconate and ketogluconates metabolism 1.3 T2D_unique_58702_1_648_- FIG00000372 15 7 31 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_58774_119_877_+ FIG00000480 29 9 32 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_58805_1_185_- FIG00005464 45 7 45 Ascorbate-specific PTS system, EIIA component (EC 2.7.1.-) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_58820_301_1078_- FIG00059211 23 6 25 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_58830_703_1078_- FIG00007941 72 12 73 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_58845_425_922_- FIG00132839 23 5 25 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_58867_1_943_+ FIG00054459 195 33 195 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_58905_1_202_- FIG00000387 45 8 45 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_58918_155_1076_- FIG00000368 33 11 55 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_58948_1_933_- FIG00000402 117 22 119 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_58967_215_808_+ FIG00000175 129 20 129 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_58992_477_1076_+ FIG00034392 76 15 77 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_58997_1_396_- FIG00016110 76 12 77 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_59081_1_199_- FIG00080955 44 8 44 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_59082_379_1026_+ FIG00000279 77 16 78 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_59100_946_1074_- FIG00000328 8 2 9 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_59103_1_667_- FIG00048839 62 11 63 Alpha-N-acetylglucosaminidase (EC 3.2.1.50) Chitin and N-acetylglucosamine utilization 2 T2D_unique_59103_677_1003_- FIG00004308 12 3 13 N-acetylglucosamine related transporter, NagX Chitin and N-acetylglucosamine utilization 2 T2D_unique_59150_781_1074_+ FIG00001548 5 4 6 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_59169_468_1049_+ FIG00012067 76 14 77 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_59190_156_890_+ FIG00001054 8 2 9 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_59194_1_866_- FIG00000117 108 19 110 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_59203_1_942_+ FIG00002385 54 12 67 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_59251_1_126_- FIG00000279 9 3 10 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_59254_1_554_- FIG00000098 36 9 37 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_59302_331_882_- FIG00000367 86 14 87 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_59314_760_915_+ FIG00000494 4 2 5 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_59320_562_1032_+ FIG00000356 41 9 42 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_59341_1_355_- FIG00006691 68 11 68 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_59383_291_662_- FIG01955919 8 3 10 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_59427_473_1071_+ FIG00000367 35 10 36 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_59473_1_1016_+ FIG00000385 269 40 269 Cell division protein FtsA Cell Division Cluster 1.x T2D_unique_59486_171_728_+ FIG00016566 28 9 29 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_59493_20_1033_+ FIG00029916 263 39 263 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_59556_1_204_+ FIG00007941 35 7 35 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_59576_1_1013_- FIG00000356 7 3 10 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_59602_1_307_+ FIG00000221 33 7 35 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_59672_736_1068_- FIG00000803 10 3 11 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_unique_59746_617_1030_+ FIG00000402 45 9 46 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_59784_1_472_+ FIG00011537 6 2 7 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_59786_380_898_- FIG00001469 129 20 129 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_59801_747_1067_+ FIG00000897 64 10 65 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_59821_1_580_+ FIG00008348 18 6 20 Predicted transcriptional regulator of N-Acetylglucosamine utilization, GntR family Chitin and N-acetylglucosamine utilization 2 T2D_unique_59864_475_1011_+ FIG01304601 13 3 15 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_59882_597_1066_+ FIG00340292 5 3 7 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_59934_1_249_+ FIG00229386 22 4 24 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_59945_1_298_- FIG00000191 15 5 17 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_59956_444_1065_+ FIG00000453 63 12 64 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_59981_1_967_- FIG00000113 236 37 237 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_59995_1_781_- FIG00018396 196 29 196 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_59998_1_1065_+ FIG00000102 232 38 233 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_60004_1_399_+ FIG00145793 101 16 101 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase (EC 6.3.2.7) Peptidoglycan biosynthesis--gjo 1 T2D_unique_60085_302_1009_+ FIG00026918 142 22 145 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_60095_1_607_- FIG00001522 28 8 30 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_60112_263_1063_- FIG00006128 168 26 168 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_60113_1_416_- FIG00002541 46 9 47 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_60160_1_971_- FIG00132994 68 17 70 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_60179_262_1063_+ FIG00094401 132 21 133 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_60188_303_1010_+ FIG00000241 128 24 129 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_60189_591_1034_+ FIG00945384 33 7 39 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_60197_1_180_+ FIG00000151 28 5 28 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_60197_191_1062_+ FIG00067681 155 28 178 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_60220_335_1062_+ FIG00007339 8 4 12 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_60284_474_1031_+ FIG00000343 87 13 89 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_60301_634_936_- FIG00049433 19 4 20 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_60305_735_1061_+ FIG00000070 16 7 20 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_60340_205_993_- FIG00001269 206 30 206 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_60346_1_981_- FIG00041038 29 10 34 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_60358_1_362_+ FIG00024851 84 14 84 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_60374_1_1009_+ FIG00744931 8 4 11 Phage tail assembly Phage tail proteins 2 4 T2D_unique_60378_1_167_- FIG00000189 30 6 31 LSU ribosomal protein L27p CBSS-176279.3.peg.868 1.x T2D_unique_60378_201_608_- FIG00000276 36 9 38 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_unique_60383_304_1060_+ FIG00018369 33 7 35 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_60490_1_634_- FIG00000422 50 7 51 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_60522_856_1059_+ FIG00561498 6 2 7 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_60537_306_1001_+ FIG00048839 18 5 21 Alpha-N-acetylglucosaminidase (EC 3.2.1.50) Chitin and N-acetylglucosamine utilization 2 T2D_unique_60548_1_1025_+ FIG00019478 267 39 267 Pyruvate oxidase (EC 1.2.3.3) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_60576_1_374_+ FIG00001146 29 6 30 GTP cyclohydrolase I (EC 3.5.4.16) type 2 Zinc regulated enzymes 1 T2D_unique_60606_1_505_+ FIG00003788 3 2 4 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_60613_272_1024_+ FIG00005727 20 8 22 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_60640_1_265_+ FIG00000645 62 10 62 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_60640_333_1028_+ FIG00000645 195 26 195 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_60685_321_785_- FIG00000243 28 11 29 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_60703_1_999_+ FIG00000467 32 7 50 Biotin synthase (EC 2.8.1.6) Biotin biosynthesis 1X T2D_unique_60707_1_330_+ FIG00000350 61 11 61 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_60758_551_1056_- FIG00004763 23 5 27 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_60810_1_214_+ FIG00093180 3 2 7 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_60852_1_350_- FIG00000824 77 13 77 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_60853_1_697_+ FIG00000113 36 8 40 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_60876_1_311_+ FIG01303805 46 9 46 Maltodextrin phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_60888_1_272_- FIG00000763 5 4 6 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_60892_1_479_+ FIG00000529 36 10 39 Formate dehydrogenase chain D (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_60961_1_989_- FIG00046929 89 20 91 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_60978_165_500_+ FIG00009628 71 12 71 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_60999_1_901_- FIG00001865 43 14 46 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_61059_683_997_- FIG00001470 30 6 31 Signal recognition particle associated protein Two cell division clusters relating to chromosome partitioning 1 T2D_unique_61121_1_318_+ FIG00071623 80 12 80 Naphthoate synthase (EC 4.1.3.36) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_61152_1_1007_+ FIG00000683 273 39 274 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Methionine Biosynthesis 8 T2D_unique_61176_1_397_- FIG00028203 15 4 17 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_61212_1_460_+ FIG00000556 116 18 116 2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55) Chorismate Synthesis 1 T2D_unique_61236_381_1004_+ FIG00043527 35 10 36 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_61263_646_1051_+ FIG00019251 11 3 13 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_61272_1_240_- FIG00000070 20 6 24 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_61272_340_936_- FIG00023369 75 18 79 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_61284_1_269_+ FIG00004170 65 10 65 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_61306_1_591_+ FIG00018699 6 9 29 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_61311_279_1050_- FIG00002416 52 10 53 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_61333_838_1050_+ FIG00000356 39 6 40 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_61374_1_481_- FIG00002463 40 10 41 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_61429_281_1049_- FIG00018865 13 5 17 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_61434_296_886_+ FIG00000584 25 9 27 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_61449_1_1005_+ FIG00011468 14 5 17 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_61454_622_1032_+ FIG00001548 48 9 49 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_61463_1_988_- FIG00061313 12 7 14 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_61481_1_505_+ FIG00000377 46 10 47 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_61524_1_1048_+ FIG00003433 239 38 240 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_61556_1_249_- FIG00561498 8 2 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_61556_324_1025_- FIG00052605 85 17 86 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_61569_252_929_- FIG00048580 72 12 73 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_61609_1_262_+ FIG00007328 5 2 6 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_61614_51_1047_+ FIG00000402 238 37 239 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_61645_529_663_- FIG01955902 3 3 4 Rubredoxin Rubrerythrin 2 T2D_unique_61663_343_819_- FIG00001491 138 19 138 Peroxide stress regulator PerR, FUR family Oxidative stress 1.2 T2D_unique_61698_339_671_+ FIG00008507 3 2 4 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_61703_1_242_+ FIG01010650 4 2 5 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_61717_1_183_+ FIG00002992 19 4 22 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_61721_812_1045_+ FIG00048014 18 4 19 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_61735_634_876_+ FIG00002947 5 3 7 Chemotaxis protein CheC -- inhibitor of MCP methylation Bacterial Chemotaxis 9 T2D_unique_61744_499_975_- FIG00001366 66 14 67 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_61767_706_1044_+ FIG00000738 77 11 77 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_61779_1_201_+ FIG00000695 9 3 10 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_61785_1_822_- FIG00000477 89 17 90 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_61800_141_791_+ FIG00000620 48 12 50 Phosphoheptose isomerase (EC 5.3.1.-) CBSS-160492.1.peg.550 1 T2D_unique_61822_1_580_- FIG00000114 21 10 51 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_61866_621_1044_+ FIG00000113 10 5 11 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_61985_745_1043_+ FIG00006463 62 10 63 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_61998_1_719_- FIG00000539 149 24 151 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_62030_695_1043_+ FIG01007502 3 2 4 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_62042_1_181_- FIG00000017 9 3 10 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_62053_710_1043_+ FIG00047056 39 8 40 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_62083_1_413_- FIG00000252 4 2 6 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_62084_1_556_+ FIG00000370 22 9 32 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_62087_1_801_+ FIG00121768 42 12 45 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_62101_1_597_+ FIG00092279 153 23 153 Xylose-responsive transcription regulator, ROK family Xylose utilization 1 T2D_unique_62121_1_1042_- FIG00008941 62 13 66 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_62124_1_731_- FIG00003715 113 18 114 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_62198_1_240_- FIG00007157 9 2 11 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_62206_1_203_- FIG00045144 38 6 38 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_62227_1_320_- FIG00000494 19 5 20 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_62253_1_607_+ FIG00029916 43 10 45 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_62275_298_651_- FIG00000815 20 4 21 Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE Biogenesis of c-type cytochromes 1.1 T2D_unique_62278_610_1040_+ FIG00000241 17 5 19 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_62317_1_136_+ FIG00006151 11 3 11 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_62317_242_1040_- FIG00007079 23 8 24 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_62320_1_1040_- FIG00034293 29 9 30 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_62344_1_608_+ FIG00001675 29 8 31 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_62437_792_1039_+ FIG00904859 11 2 12 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_unique_62449_326_700_+ FIG00006336 96 14 96 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_62452_894_1038_+ FIG00006764 6 2 7 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_62475_285_1038_- FIG00000080 76 17 78 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_62497_626_1021_+ FIG00000477 14 5 16 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_62498_1_252_+ FIG00046929 31 8 32 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_62501_802_975_- FIG00000539 9 3 10 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_62522_1_1038_+ FIG00000402 160 32 162 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_62526_1_634_+ FIG00000108 53 12 56 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_62530_1_479_+ FIG00132586 10 2 12 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_62534_726_1038_+ FIG00049915 55 9 56 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_62540_254_799_+ FIG00000494 38 9 39 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_62546_1_905_- FIG00000402 78 16 81 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_62550_1_780_+ FIG00000402 71 14 73 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_62553_1_536_- FIG00000001 82 17 84 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_62553_693_983_+ FIG00229386 14 3 15 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_62571_524_910_- FIG00000494 18 6 20 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_62599_497_979_- FIG00038920 14 4 15 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_62619_1_1037_- FIG00008736 48 13 51 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_62620_1_644_+ FIG00002470 15 4 18 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_62625_735_1013_+ FIG00000578 32 7 33 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_62629_345_671_+ FIG00000812 71 12 72 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_62636_451_732_+ FIG00002385 29 6 30 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_62659_1_272_- FIG00133229 14 4 16 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_62662_851_1030_+ FIG00022899 30 5 31 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_62663_26_730_- FIG00001145 15 5 17 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_62671_1_784_+ FIG00000098 159 27 161 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_62721_213_842_+ FIG00001550 56 10 59 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_62735_1_271_+ FIG00007157 40 7 42 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_62760_197_1035_+ FIG00035113 173 29 173 Aerotaxis sensor receptor protein Bacterial Chemotaxis 9 T2D_unique_62796_1_1035_+ FIG00055715 253 39 254 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_62807_65_415_+ FIG00047414 14 3 15 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_62832_20_289_- FIG00078083 28 5 30 5'-nucleotidase family protein in cluster with NagD-like phosphatase Purine conversions 4.1118100 T2D_unique_62848_143_1034_+ FIG00060517 76 17 77 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_62869_1_224_- FIG00104848 23 4 24 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_62871_1_200_- FIG00001865 48 7 48 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_62871_220_1034_- FIG00000721 127 20 128 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_62895_488_1034_+ FIG01260980 43 11 44 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_62923_76_465_+ FIG00000892 23 5 24 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_62930_370_612_+ FIG00002541 18 4 19 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_62957_563_1033_- FIG00001774 32 5 33 Late competence protein ComGA, access of DNA to ComEA Gram Positive Competence 3100 T2D_unique_62958_77_652_+ FIG00000177 106 18 107 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_62990_404_715_+ FIG00000441 73 10 73 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_62990_741_1033_+ FIG00000224 13 3 16 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_63004_1_967_- FIG00026918 201 31 203 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_63035_486_806_- FIG01303822 88 12 88 Hypothetical protein VC0266 (sugar utilization related?) VC0266 1 T2D_unique_63072_560_937_- FIG00004453 101 15 101 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_63074_497_1032_- FIG00000434 33 6 34 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_63079_1_530_+ FIG00001882 116 19 116 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_63102_1_385_+ FIG00000538 32 7 33 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_unique_63104_356_1032_+ FIG00003394 10 4 12 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_63125_702_1032_- FIG00000288 9 4 10 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_63127_1_323_- FIG00007751 94 13 94 Late competence protein ComC, processing protease Gram Positive Competence 3100 T2D_unique_63149_1_427_- FIG00021289 9 3 11 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_63163_94_597_- FIG00000325 116 18 117 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_63163_660_950_- FIG00041038 67 11 67 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_63181_439_1031_+ FIG00006551 50 13 52 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_63207_1_1031_- FIG00009564 5 5 7 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_63225_662_1031_+ FIG00001198 3 3 5 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_63234_1_184_- FIG00059124 35 6 35 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_63234_187_1031_- FIG00135993 209 31 209 Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) Isoprenoid Biosynthesis 2.x T2D_unique_63237_1_703_+ FIG00000065 201 28 201 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_63250_1_194_- FIG00001436 43 7 43 GlpG protein (membrane protein of glp regulon) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_63251_1_664_- FIG00031250 167 26 167 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_63291_1_754_+ FIG00007957 202 29 202 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_63316_1_947_- FIG00076542 105 20 106 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_63322_1_1030_+ FIG00000392 126 24 128 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_63354_1_378_- FIG00000477 21 6 23 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_63383_268_1029_+ FIG00045575 44 10 48 O-antigen export system, permease protein Rhamnose containing glycans 4.1 T2D_unique_63405_1_1006_+ FIG00000990 72 16 73 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_63425_1_618_+ FIG00021517 13 3 15 Cell division protein FtsQ Cell Division Cluster 1.x T2D_unique_63435_1_128_- FIG00000356 22 4 23 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_63448_228_539_- FIG00004843 12 5 13 Protein YidD Cell Division Subsystem including YidCD 1 T2D_unique_63450_277_1029_- FIG00000163 75 15 77 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_63465_1_511_- FIG00021289 60 11 61 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_63479_465_674_+ FIG00006128 10 3 11 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_63479_770_1018_+ FIG01954097 4 3 5 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_63504_1_997_- FIG01955782 271 39 271 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_63520_1_356_- FIG00051957 93 14 93 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_63521_554_1028_- FIG00006332 122 17 122 Transcriptional antiterminator with PTS regulation domain, SPy0181 ortholog L-ascorbate utilization (and related gene clusters) 29 T2D_unique_63526_1_1028_+ FIG00006151 12 2 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_63536_1_368_- FIG00001548 12 3 15 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_63544_1_679_+ FIG00003394 183 27 183 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_63544_826_1028_+ FIG00001088 38 6 38 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_63580_714_1025_+ FIG00003460 18 6 19 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_63586_1_319_- FIG00009149 9 3 10 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_63593_487_918_+ FIG01303889 14 4 16 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) Zinc regulated enzymes 1 T2D_unique_63594_409_810_+ FIG00000163 6 4 9 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_63605_200_442_- FIG00000271 50 9 50 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_unique_63605_499_1028_- FIG00000263 99 17 100 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_63611_1_930_- FIG00038343 5 3 7 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_63620_235_1023_+ FIG00024930 92 17 93 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_63637_1_718_+ FIG00719736 4 3 6 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_63705_362_1026_- FIG00006336 187 26 189 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_63729_1_984_+ FIG00001774 249 37 250 Late competence protein ComGA, access of DNA to ComEA Gram Positive Competence 3100 T2D_unique_63748_1_531_+ FIG00005216 144 20 144 Sulfate permease Cysteine Biosynthesis 2.17 T2D_unique_63764_1_502_+ FIG00023369 16 9 28 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_63779_56_1026_- FIG00136922 55 13 57 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_63790_1_381_- FIG00001548 8 2 9 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_63806_1_499_- FIG00000212 106 15 107 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_63822_1_1025_+ FIG00000118 267 40 268 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_63865_1_1023_+ FIG00000015 24 7 28 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_63999_1_569_- FIG00136866 23 8 25 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_64008_1_159_+ FIG00016663 29 4 29 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_64008_188_667_+ FIG00012531 3 2 4 TRAP-type transport system, small permease component, predicted N-acetylneuraminate transporter Sialic Acid Metabolism 1.x T2D_unique_64013_690_1001_+ FIG00002560 82 12 82 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_64018_1_1005_+ FIG00000680 270 39 271 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_64032_1_1023_- FIG00021289 63 16 68 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_64036_162_881_+ FIG00000402 22 7 40 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_64094_455_1015_+ FIG00521220 17 5 19 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_64105_212_1009_+ FIG00000102 15 4 23 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_64120_200_1022_+ FIG00001522 90 18 92 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_64134_881_1022_+ FIG00005727 5 2 6 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_64139_1_1022_+ FIG00561498 199 30 201 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_64147_1_284_- FIG00005111 14 5 15 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_unique_64158_1_225_+ FIG00001882 7 4 8 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_64190_777_1021_+ FIG00000317 16 4 17 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_64198_1_380_- FIG00000121 69 13 69 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_64265_863_1020_- FIG00005283 12 4 14 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_64285_1_405_- FIG00000439 3 3 4 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_64312_1_255_- FIG00134889 7 2 9 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_64315_1_498_+ FIG00001145 95 17 96 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_64347_1_602_+ FIG00024930 23 4 24 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_64357_1_574_+ FIG00000289 47 8 48 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_64383_1_1019_- FIG00000011 16 6 18 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_64384_1_699_+ FIG00561498 56 11 58 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_64428_1_355_- FIG00031969 26 5 27 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_64440_1_435_- FIG01257503 50 9 52 Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27) Inositol catabolism 5.x T2D_unique_64467_1_600_- 5 4 7 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_64487_336_1018_+ FIG00000289 103 19 105 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_64514_1_269_- FIG00011622 16 4 17 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_64561_1_134_+ FIG00945384 3 2 4 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_64567_780_1017_+ FIG00000212 8 4 10 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_64568_1_803_- FIG00141373 194 31 195 Regulatory protein SusR Cellulosome 1.x T2D_unique_64629_1_456_+ FIG00000494 120 17 121 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_64659_1_716_- FIG00073301 14 5 17 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_64668_1_386_+ FIG01260980 16 7 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_64697_1_233_- FIG00041038 3 2 4 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_64716_571_1016_- FIG00135469 17 6 19 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_64732_1_495_- FIG00000223 47 8 48 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_64751_96_452_+ FIG00013638 13 4 14 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_64758_603_1015_+ FIG00000258 29 7 31 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_64858_887_1014_+ FIG00000200 12 2 13 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_unique_64874_1_255_+ FIG00002716 6 4 9 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_64934_32_1014_+ FIG00000532 119 27 123 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_64946_1_200_+ FIG00000770 30 6 32 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_64957_1_603_+ FIG00000494 40 8 42 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_64973_19_972_- FIG00005728 20 8 22 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_65023_858_1007_+ FIG00001577 26 5 26 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_65055_1_400_+ FIG00052300 13 4 14 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_65056_1_884_- FIG00000962 11 7 30 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_65064_358_1012_- FIG00000089 168 25 168 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_65065_813_1012_- FIG00092649 5 2 7 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_65077_637_1005_+ FIG00023573 18 6 20 CRISPR-associated negative autoregulator CRISPRs 1 T2D_unique_65092_1_153_+ FIG00000111 42 6 42 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_65108_363_1012_- FIG00135554 42 10 44 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_65113_1_925_+ FIG00011468 12 6 14 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_65115_1_172_- FIG00002110 4 2 5 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_65115_300_1012_- FIG00080955 148 24 149 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_65116_159_305_+ FIG00004764 5 2 6 Ammonium transporter Ammonia assimilation 1 T2D_unique_65125_700_1002_+ FIG00000892 8 2 9 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_65135_1_657_- FIG00000402 25 6 27 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_65141_212_1011_+ FIG00521220 4 3 6 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_65143_1_586_- FIG00846773 22 6 23 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_65148_87_800_- FIG00006868 33 10 35 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_65194_1_758_- FIG00067681 204 30 204 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_65194_767_1011_- FIG00000151 58 9 58 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_65207_1_207_+ FIG00000128 6 2 7 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_65233_1_567_- FIG00000351 114 19 114 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_65234_603_1011_- FIG00133087 4 2 5 Similar to phosphoglycolate phosphatase, clustered with ribosomal large subunit pseudouridine synthase C 2-phosphoglycolate salvage 1 T2D_unique_65243_1_504_+ FIG00023369 9 2 11 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_65245_1_315_+ FIG00000317 27 5 28 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_65278_257_787_+ FIG00002689 6 3 7 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_65278_800_1010_+ FIG00134060 9 3 10 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_65304_598_1010_- FIG00047056 72 11 73 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_65307_811_1010_+ FIG00024930 23 4 24 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_65364_1_144_+ FIG00041038 19 3 21 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_65366_344_868_- FIG00000413 129 20 129 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_65368_148_639_+ FIG00050243 9 4 14 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_65376_376_1009_+ FIG00023946 8 8 27 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_65449_355_1009_+ FIG00018457 35 8 36 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_65471_1_1009_- FIG00040870 101 23 103 CoB--CoM heterodisulfide reductase subunit A (EC 1.8.98.1) Anaerobic respiratory reductases 3 T2D_unique_65481_1_1008_+ FIG00014079 12 7 17 HipA protein Persister Cells 1 T2D_unique_65504_592_1008_+ FIG00047056 16 3 18 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_65506_1_233_- FIG00000372 5 3 6 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_65529_1_452_+ FIG00005590 117 17 117 Hypothetical protein DUF194, DegV family CBSS-370552.3.peg.1240 1 T2D_unique_65538_1_243_+ FIG00000258 11 4 12 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_65543_1_1008_- FIG00000494 13 5 17 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_65547_1_419_+ FIG00074225 13 7 15 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_65561_1_504_+ FIG00013638 3 2 5 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_65574_371_1008_+ FIG00000482 160 24 160 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_65622_1_807_+ FIG00133515 151 26 151 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_65622_816_1007_+ FIG00007957 27 5 27 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_65647_78_881_+ FIG01260980 155 24 158 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_65659_41_1007_- FIG00001469 33 9 35 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_65702_733_1006_+ FIG00000422 38 9 39 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_65706_696_1006_- FIG00005022 12 3 13 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_65734_1_299_- FIG00000895 37 10 38 Alanine dehydrogenase (EC 1.4.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_65754_1_205_+ FIG00000824 6 3 7 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_65757_1_668_+ FIG00561498 15 5 18 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_65794_550_1006_- FIG00002890 47 8 51 Arabinose operon regulatory protein L-Arabinose utilization 1 T2D_unique_65831_82_492_+ FIG01304886 112 16 112 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_unique_65831_511_1002_+ FIG00136866 35 7 45 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_65869_1_252_+ FIG00001253 8 3 11 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_65875_400_570_+ FIG01307086 32 6 32 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_65928_1_504_- FIG00000477 45 10 47 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_65954_725_1004_+ FIG00000372 23 5 25 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_66015_1_516_+ FIG00006463 118 20 119 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_66118_434_1003_- FIG00000402 69 14 71 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_66153_1_298_- FIG00001960 4 2 6 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_66185_1_1002_- FIG00021289 8 6 12 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_66202_1_364_+ FIG00000260 11 4 14 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_66248_802_1001_- FIG00000435 34 7 35 Exodeoxyribonuclease VII small subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_66285_1_174_- FIG00045144 8 3 9 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_66296_1_484_- FIG00002239 120 19 120 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_66304_1_1001_+ FIG00041038 47 15 50 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_66314_6_971_+ FIG01260980 250 35 251 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_66365_757_1000_+ FIG00031250 66 9 66 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_66375_1_916_+ FIG00000681 7 8 12 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_unique_66396_1_185_- FIG00133288 4 2 5 Excinuclease ABC subunit A, dimeric form DNA repair, UvrABC system 1 T2D_unique_66441_692_1000_- FIG00000979 8 2 9 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_unique_66468_622_999_+ FIG00000013 81 14 81 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_66500_418_999_+ FIG00019508 75 14 76 Phage major tail protein Phage tail proteins 2 4 T2D_unique_66572_754_998_- FIG00007694 61 9 61 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_66584_1_998_+ FIG00080955 213 33 215 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_66606_1_182_- FIG00001036 3 2 4 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_66676_527_998_- FIG00050243 3 2 5 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_66688_854_998_+ FIG00011115 15 3 16 PTS system, cellobiose-specific IIA component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_66717_1_561_+ FIG00012267 130 21 130 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_66732_1_998_+ FIG00000594 81 16 83 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_66776_1_812_+ FIG00003788 226 32 227 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_66813_1_997_- FIG00029916 237 34 238 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_66822_52_594_- FIG00000128 135 20 135 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_66833_84_821_- FIG00002449 7 5 10 Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48) Exopolysaccharide Biosynthesis 1.0 T2D_unique_66872_198_996_- FIG00000370 77 16 78 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_66942_816_996_- FIG00136692 17 5 17 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_66956_1_223_+ FIG00000474 16 5 16 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_66986_641_995_+ FIG01260980 55 10 57 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_66997_1_510_- FIG00001347 98 15 99 Chitinase (EC 3.2.1.14) Chitin and N-acetylglucosamine utilization 2 T2D_unique_67014_1_334_- FIG00000381 43 9 44 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_unique_67014_655_888_+ FIG00000266 21 6 23 LSU ribosomal protein L28p A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_67015_555_995_- FIG00076285 19 7 21 Substrate-specific component STY3230 of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_67021_1_933_+ FIG00004828 261 38 261 Integral membrane protein LafC, accessory function in glycolipid and LTA synthesis Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_67089_1_374_- FIG00000098 28 5 29 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_67121_154_417_+ FIG00023268 4 3 5 DNA-binding protein HU-beta DNA structural proteins, bacterial 1.1100 T2D_unique_67123_1_285_- FIG00004917 9 2 11 Protein AraJ precursor L-Arabinose utilization 1 T2D_unique_67140_698_994_- FIG00000450 23 6 24 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_67146_47_340_- FIG00229216 62 11 62 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_67169_1_212_- FIG00451095 36 5 37 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_67202_556_993_- FIG00018865 81 12 81 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_67213_777_993_+ FIG00028476 35 7 36 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_67232_1_460_+ FIG00023004 10 5 12 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_67255_248_993_+ FIG00024930 96 18 97 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_67263_1_808_+ FIG00001168 71 18 74 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_67270_325_993_+ FIG00136866 37 8 39 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_67271_782_993_+ FIG01955902 8 2 9 Rubredoxin Rubrerythrin 2 T2D_unique_67315_1_296_+ FIG00000122 28 8 29 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_67316_1_428_- FIG01260980 17 5 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_67322_821_992_+ FIG00000402 3 3 5 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_67327_783_992_+ FIG00001450 42 8 42 Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34) Isoprenoid Biosynthesis 2.x T2D_unique_67329_517_992_+ FIG00001094 68 13 69 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_67350_1_686_- FIG00000341 82 19 85 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_67403_1_584_+ FIG00000402 79 15 82 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_67421_1_991_- FIG00066643 15 4 17 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_67426_1_902_+ FIG00002332 214 29 216 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_unique_67453_98_991_+ FIG00000560 25 6 28 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_67454_638_991_+ FIG00001548 20 5 22 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_67458_1_512_- FIG00000824 52 11 54 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_67474_1_991_+ FIG00006336 272 39 272 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_67480_1_991_+ FIG00029916 155 24 156 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_67484_1_395_+ FIG00000157 58 9 59 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_67484_415_924_+ FIG00000433 131 20 131 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_67499_1_316_- FIG00000812 64 9 65 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_67499_740_991_+ FIG00001750 34 6 35 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_67514_109_831_- FIG00001088 10 5 19 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_67524_1_505_+ FIG00000308 18 5 20 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_67559_731_990_+ FIG00000442 23 8 24 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_67571_1_678_- FIG00000352 87 19 90 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_67623_1_932_+ FIG00001384 173 29 174 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_67626_1_989_+ FIG00138182 78 15 80 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_67669_1_386_+ FIG00000382 101 14 101 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_67675_1_557_- FIG00050603 112 18 113 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_67717_785_988_- FIG00001145 11 3 12 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_67728_1_241_- FIG00000680 42 7 44 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_67743_683_988_+ FIG00041038 69 10 69 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_67771_1_937_+ FIG00000245 96 21 97 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_67804_1_580_- FIG00000575 58 13 61 L-aspartate oxidase (EC 1.4.3.16) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_67815_600_988_- FIG00000594 9 4 19 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_67873_582_987_+ FIG00000510 4 3 5 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_67894_1_987_+ FIG00000423 51 10 58 Dethiobiotin synthetase (EC 6.3.3.3) Biotin biosynthesis 1X T2D_unique_67909_1_987_- FIG01260980 62 19 64 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_67910_1_417_+ FIG00001577 109 16 109 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_67916_1_987_+ FIG00000441 87 19 106 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_67928_307_987_- FIG00001824 33 14 35 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_67980_1_894_- FIG00001065 19 8 23 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_68039_1_986_+ FIG01260980 251 38 251 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_68040_850_986_+ FIG00008778 14 4 14 Maltose operon transcriptional repressor MalR, LacI family Maltose and Maltodextrin Utilization 1.x T2D_unique_68044_505_986_- FIG00006151 15 7 18 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_68060_1_177_- FIG00006151 30 5 30 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_68065_390_842_+ FIG00000382 67 12 68 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_68085_712_985_+ FIG00002718 18 4 20 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_68088_71_421_- FIG00062547 16 5 18 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_68175_1_626_- FIG00007373 21 7 24 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_68210_828_984_+ FIG00000277 8 3 9 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_68220_58_390_- FIG00000636 29 6 33 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_68226_626_984_+ FIG00000040 42 9 52 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_68268_407_984_- FIG00044735 66 10 68 Aminopeptidase S (Leu, Val, Phe, Tyr preference) (EC 3.4.11.24) EC 3.4.11.- Aminopeptidases 1 T2D_unique_68277_1_984_- FIG00000793 265 38 266 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_68278_180_984_+ FIG00028476 25 7 28 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_68288_75_593_+ FIG00093180 27 6 32 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_68289_848_984_+ FIG00229386 8 2 9 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_68308_1_527_- FIG00011814 84 16 84 Transcriptional repressor of arabinoside utilization operon, GntR family L-Arabinose utilization 1 T2D_unique_68321_1_348_+ FIG00080231 91 13 91 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_68321_490_983_+ FIG00000351 49 13 51 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_68323_1_635_+ FIG00005237 60 14 61 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_68324_1_263_- FIG00000683 27 5 29 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Methionine Biosynthesis 8 T2D_unique_68348_1_651_+ FIG00040528 141 24 141 Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282) Quinate degradation 3 T2D_unique_68348_665_983_+ FIG00000224 71 12 71 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_68365_480_845_- FIG00001470 82 14 82 Signal recognition particle associated protein Two cell division clusters relating to chromosome partitioning 1 T2D_unique_68395_1_710_+ FIG00006463 148 24 149 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_68395_799_983_+ FIG00016663 14 3 15 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_68424_1_287_+ FIG00018865 9 2 10 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_68481_844_982_+ FIG00001067 9 2 9 Rubrerythrin Oxidative stress 1.2 T2D_unique_68504_363_982_+ FIG00030174 169 25 169 Predicted arginine uptake transporter Arginine Biosynthesis extended 1.0 T2D_unique_68510_353_940_+ FIG00003555 77 14 88 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_68558_588_981_+ FIG00030688 46 9 47 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_68565_1_146_- FIG00001547 23 5 23 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_68596_672_981_- FIG00000415 71 11 71 Ribose 5-phosphate isomerase A (EC 5.3.1.6) Glycolate, glyoxylate interconversions ? T2D_unique_68607_502_981_+ FIG00028203 90 16 90 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_68608_63_981_+ FIG00059211 253 37 253 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_68615_1_471_+ FIG00000370 85 15 86 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_68652_646_981_+ FIG00028203 23 5 25 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_68674_190_573_- FIG00000252 38 7 39 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_68674_719_980_- FIG00000252 10 3 11 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_68690_1_980_- FIG00132617 139 23 141 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_68691_683_980_- FIG00000402 24 5 25 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_68692_1_891_+ FIG00012814 139 22 140 Spore cortex-lytic enzyme, N-acetylglucosaminidase SleL (EC 3.2.1.-) Spore germination 1 T2D_unique_68707_1_454_+ FIG00001882 18 7 21 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_68755_763_980_- FIG00000156 7 3 8 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_68765_1_980_- FIG00846773 11 4 15 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_68778_1_980_- FIG00000372 246 37 246 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_68785_346_980_+ FIG00521176 11 3 13 fructose response regulator of fruA and EII fructose/mannose Fructose and Mannose Inducible PTS 2 T2D_unique_68793_707_979_+ FIG00025216 3 2 6 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_68821_1_200_+ FIG00001039 13 2 14 Ribonucleotide reduction protein NrdI Ribonucleotide reduction 1 T2D_unique_68829_1_979_- FIG00000448 243 38 243 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_68846_1_140_+ FIG00031250 14 3 15 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_68853_1_916_- FIG00002470 18 6 21 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_68875_32_742_+ FIG00003596 7 5 10 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_68894_457_979_- FIG00000402 149 21 149 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_68902_511_979_- FIG00000036 68 14 70 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_68905_768_979_+ FIG00038726 43 7 43 Ferric siderophore transport system, periplasmic binding protein TonB Hemin transport system 1 T2D_unique_68931_37_978_+ FIG00000095 225 34 226 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_68947_1_258_- FIG00035634 6 3 8 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_69027_753_978_+ FIG00006463 8 3 9 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_69048_748_977_+ FIG00000086 63 9 63 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_69063_795_977_+ FIG00001088 10 2 11 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_69080_1_482_- FIG00003672 26 9 29 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_unique_69104_674_943_+ FIG00009229 54 10 54 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_69165_1_976_+ FIG00001882 219 33 219 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_69187_560_976_- FIG01239241 7 3 8 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_69199_153_731_+ FIG00000080 17 7 22 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_69200_226_976_+ FIG00001695 124 23 126 D-serine dehydratase (EC 4.3.1.18) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_69207_343_976_+ FIG00000391 137 22 138 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_69230_6_975_- FIG00001522 13 6 15 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_69231_685_975_- FIG00000098 30 5 31 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_69240_1_429_- FIG00003394 21 5 23 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_69356_1_210_- FIG00001818 23 7 24 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_69445_633_974_+ FIG00041038 85 13 85 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_69475_1_332_- FIG01239241 7 4 8 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_69488_1_973_- FIG00018457 13 8 15 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_69555_1_503_- FIG00000539 27 9 32 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_69556_1_973_- FIG00051439 69 20 71 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_69557_1_256_+ FIG00006945 18 5 19 Anaerobic sulfite reductase subunit B Anaerobic respiratory reductases 3 T2D_unique_69568_1_425_- FIG00020613 109 17 109 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_69569_1_268_- FIG00000402 5 4 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_69572_1_973_+ FIG00000476 32 6 36 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_69602_421_972_- FIG00023943 109 17 111 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_69611_90_380_- FIG00002504 8 3 9 DNA-damage-inducible protein J Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_69617_1_857_- FIG00000782 57 13 59 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_69653_1_875_- FIG00029322 35 12 36 Aerobic C4-dicarboxylate transporter for fumarate, L-malate, D-malate, succunate Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_69657_1_470_+ FIG00000015 14 4 16 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_69657_541_972_+ FIG00000840 49 10 50 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_69675_228_776_+ FIG00135554 11 5 14 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_69688_1_972_- FIG00109688 50 13 52 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_69697_1_771_+ FIG01260980 39 12 41 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_69722_682_971_+ FIG00000555 34 6 36 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_69736_124_762_- FIG00146664 20 7 21 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_69766_208_423_- FIG00755081 43 7 44 Cystathionine beta-lyase (EC 4.4.1.8) Methionine Biosynthesis 8 T2D_unique_69770_1_573_+ FIG00022996 23 8 24 Aconitate hydratase (EC 4.2.1.3) Serine-glyoxylate cycle 1 T2D_unique_69787_1_971_+ FIG00001635 258 38 258 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_69802_474_905_+ FIG00002541 48 9 49 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_69816_1_729_+ FIG00016555 38 10 41 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_69823_10_657_+ FIG00000811 48 12 50 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_69845_1_970_+ FIG00117785 70 17 72 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_unique_69869_578_970_- FIG00079822 33 7 34 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_69916_1_970_- FIG00002130 273 39 273 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_69927_613_970_+ FIG00000560 92 13 92 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_69943_684_969_+ FIG00003506 20 6 21 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_69956_1_340_- FIG00001198 51 8 52 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_69980_1_223_+ FIG00023019 38 6 39 Carbonic anhydrase (EC 4.2.1.1) Zinc regulated enzymes 1 T2D_unique_70037_1_361_- FIG00004528 12 5 14 Di-/tripeptide transporter Proton-dependent Peptide Transporters 1 T2D_unique_70055_1_415_- FIG00001179 14 4 15 Macrolide-specific efflux protein MacA Multidrug Resistance Efflux Pumps 1.12 T2D_unique_70064_536_832_+ FIG00000476 39 7 40 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_70162_444_896_+ FIG00136522 9 3 11 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_unique_70164_1_967_- FIG00001094 5 4 7 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_70200_806_967_- FIG00067248 21 4 21 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_70216_1_791_- FIG00000402 194 30 194 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_70259_1_747_+ FIG00024546 202 30 202 Phosphonoacetaldehyde hydrolase (EC 3.11.1.1) Phosphonate metabolism 1 T2D_unique_70283_353_966_- FIG00001555 162 24 162 Cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Putative oxidase COG2907 9 T2D_unique_70308_1_966_+ FIG00136193 201 33 201 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_70382_1_596_- FIG00000134 140 20 141 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_70406_1_965_+ FIG00000610 170 31 173 Flagellar motor switch protein FliG Bacterial Chemotaxis 9 T2D_unique_70431_484_965_+ FIG00059426 9 4 10 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_70464_1_965_- FIG00059211 25 11 31 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_70470_356_961_+ FIG00000532 55 11 57 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_70471_1_965_- FIG00024073 100 19 102 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_70529_1_159_- FIG00067300 7 3 8 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_70558_1_335_+ FIG00000103 11 4 12 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_70577_506_946_+ FIG00000720 28 6 30 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_70583_677_964_- FIG00000323 10 4 11 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_70600_232_964_+ FIG00000168 56 17 59 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_70610_1_232_- FIG00044735 47 8 48 Aminopeptidase S (Leu, Val, Phe, Tyr preference) (EC 3.4.11.24) EC 3.4.11.- Aminopeptidases 1 T2D_unique_70638_683_964_- FIG00047509 32 7 33 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_70660_1_804_- FIG00018699 62 15 64 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_70700_1_963_+ FIG00000038 264 38 265 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_70710_1_837_+ FIG00000962 37 13 40 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_70721_828_963_- FIG00008490 9 3 10 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_70737_1_963_- FIG00000011 89 22 91 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_70750_395_963_+ FIG00002049 70 12 71 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_70763_256_627_+ FIG00002410 34 7 35 Recombinational DNA repair protein RecT (prophage associated) DNA repair, bacterial 3 T2D_unique_70788_1_963_- FIG00000116 13 4 15 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_70821_1_210_+ FIG00719736 44 7 44 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_70836_7_585_- FIG00000858 8 3 10 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_unique_70848_311_962_+ FIG00026137 128 22 130 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_70888_131_445_+ FIG00006075 80 11 80 PTS system, galactose-specific IIB component (EC 2.7.1.69) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_70938_1_961_+ FIG00076542 267 37 268 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_70963_11_460_- FIG00000303 67 12 69 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_70976_164_961_+ FIG00026918 53 12 55 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_71056_1_483_+ FIG00058830 21 7 23 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_71056_555_960_+ FIG00000076 21 5 22 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_71122_648_960_- FIG01260980 14 4 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_71151_604_951_+ FIG00001670 73 11 75 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_71161_655_959_- FIG00000985 20 4 22 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_71165_1_148_+ FIG00059211 31 5 31 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_71219_430_959_- FIG00136522 27 9 29 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_unique_71226_1_221_- FIG00132617 54 8 54 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_71226_239_959_- FIG00000241 189 28 189 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_71322_1_958_- FIG00018699 69 14 70 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_71340_1_582_- FIG00081563 11 4 13 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_71371_1_676_- FIG00001469 40 9 42 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_71410_511_957_- FIG00000185 97 15 98 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_71415_1_957_- FIG00016514 83 17 86 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_71495_1_485_+ FIG00000317 5 3 8 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_71506_1_928_+ FIG00000865 19 8 24 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_71601_1_514_- FIG00623809 22 6 24 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_71625_302_956_- FIG00146582 22 7 24 Putative glycogen debranching enzyme, archaeal type, TIGR01561 Glycogen metabolism 3 T2D_unique_71638_679_955_+ FIG00000624 22 4 23 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_71643_1_308_- FIG00001616 27 7 28 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_71668_1_955_+ FIG00451095 11 6 13 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_71675_1_955_+ FIG00002385 6 3 10 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_71730_370_955_- FIG00067300 139 20 139 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_71757_1_556_- FIG00001522 39 8 41 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_71758_1_954_+ FIG00138182 261 38 262 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_71783_516_954_+ FIG00000085 55 10 57 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_71809_30_954_- FIG00010771 222 32 222 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_71853_1_954_+ FIG00000877 230 35 231 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_71861_1_294_+ FIG00133569 7 3 9 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_71871_1_568_+ FIG00451095 52 10 59 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_71890_736_953_+ FIG00004334 12 2 13 CRISPR-associated protein Cas2 CRISPRs 1 T2D_unique_71891_1_858_- FIG00000402 214 33 215 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_71916_1_953_+ FIG00000329 139 24 142 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_71928_1_953_+ FIG00051439 176 30 178 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_71940_1_953_- FIG00000990 89 19 91 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_71967_1_187_- FIG00000402 14 4 15 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_72018_1_223_+ FIG00003090 51 8 52 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_unique_72049_1_577_+ FIG00008708 7 4 11 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_72050_1_459_- FIG00018699 5 3 8 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_72057_485_952_+ FIG00561498 35 9 36 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_72077_410_952_- FIG00000402 13 3 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_72090_159_587_- FIG00000720 18 6 20 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_72151_608_951_+ FIG00011114 80 12 80 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_72204_533_951_+ FIG00007514 16 5 18 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_72245_275_418_- FIG00000450 16 4 17 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_72278_168_782_- FIG00019251 54 13 56 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_72304_313_950_+ FIG00000139 176 26 176 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_72307_1_388_- FIG00719736 82 13 82 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_72335_1_512_+ FIG00001384 4 2 6 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_72339_1_950_- FIG00030585 21 11 28 Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_72354_477_950_+ FIG00003251 106 16 106 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_72364_513_949_+ FIG01956071 83 14 84 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_unique_72383_689_901_- FIG00047509 44 7 45 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_72408_1_949_- FIG00000323 262 38 262 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_72418_1_949_+ FIG00000134 189 34 191 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_72428_719_949_- FIG00615494 6 3 7 DNA-binding protein HU DNA structural proteins, bacterial 1.1100 T2D_unique_72455_591_949_- FIG00001550 82 13 82 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_72458_1_802_+ FIG00001616 80 16 81 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_72470_1_652_+ FIG00038920 14 5 15 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_72474_409_949_+ FIG00598409 150 21 150 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_72495_1_290_+ FIG00598409 3 2 4 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_72516_1_262_- FIG00475203 66 10 66 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_72528_578_948_+ FIG00136692 53 12 54 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_72546_632_948_- FIG00104848 58 10 59 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_72556_1_397_+ FIG00085033 27 6 29 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_72562_1_150_+ FIG00133226 30 5 30 Dihydrolipoamide dehydrogenase of acetoin dehydrogenase (EC 1.8.1.4) Acetoin, butanediol metabolism 5 T2D_unique_72582_438_948_- FIG00050603 37 12 39 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_72596_1_948_+ FIG00000139 227 37 227 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_72609_1_947_- FIG00016514 159 30 160 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_72621_1_135_- FIG00000065 9 2 10 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_72624_256_947_+ FIG00050603 97 18 98 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_72635_395_947_- FIG00001175 150 22 150 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_72662_245_697_+ FIG00000325 15 5 16 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_72668_804_947_+ FIG00019212 3 3 4 Cobalt-precorrin-6x reductase (EC 1.3.1.54) Cobalamin synthesis 2 T2D_unique_72679_363_947_- FIG00018699 15 8 16 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_72696_738_947_+ FIG00010414 54 8 54 ComF operon protein A, DNA transporter ATPase Gram Positive Competence 3100 T2D_unique_72710_1_947_- FIG00010771 178 30 179 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_72758_5_715_- FIG00000474 76 15 77 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_72784_459_946_- FIG00073301 9 5 12 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_72829_118_456_+ FIG00000376 7 3 8 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_72860_621_945_+ FIG00001643 8 4 10 Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_72894_261_945_- FIG01260980 195 28 195 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_72972_726_945_- FIG00008507 17 3 18 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_73004_1_193_- FIG00003955 21 4 23 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_73029_1_345_- FIG00006032 83 13 83 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_73029_350_944_- FIG00000824 105 18 107 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_73044_744_944_+ FIG00018396 31 6 32 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_73066_314_944_- FIG00000552 53 10 55 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_73079_449_931_+ 11 4 13 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_73100_1_468_+ FIG00001869 16 4 19 Exoribonuclease II (EC 3.1.13.1) RNA processing and degradation, bacterial 1 T2D_unique_73109_1_198_+ FIG00000317 19 3 20 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_73123_455_943_- FIG00000088 6 3 8 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_73124_396_943_- FIG01260980 138 21 139 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_73131_182_919_+ FIG00000111 204 29 204 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_73135_1_639_- FIG00000659 6 11 30 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_73143_304_943_+ FIG00000290 44 11 46 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_73196_1_510_+ FIG00001280 14 5 16 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_73208_682_943_+ FIG00000464 26 5 27 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_73214_1_535_+ FIG00002470 11 5 20 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_73229_182_943_- FIG00007339 9 6 11 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_73242_36_770_- FIG00847536 159 24 160 Phage (Mu-like) virion morphogenesis protein Phage head and packaging 1 T2D_unique_73333_1_519_- FIG00047509 127 19 128 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_73333_530_942_- FIG00045144 97 16 97 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_73356_475_942_+ FIG00004078 69 13 71 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_73410_535_941_+ FIG00006970 4 4 9 Nickel transport system permease protein NikB (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_73412_1_882_+ FIG01260980 65 12 69 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_73426_414_941_- FIG00052730 17 3 23 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_73447_1_238_- FIG00146664 11 4 13 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_73455_1_305_- FIG00007997 54 10 54 Beta-lactamase repressor BlaI Beta-lactamase 1 T2D_unique_73466_266_941_+ FIG00002344 10 5 13 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_73492_547_941_+ FIG00080955 5 3 7 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_73504_1_282_+ FIG00001076 7 2 8 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_73553_1_740_+ FIG00002049 14 6 16 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_73553_742_940_+ FIG00018865 8 4 9 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_73567_365_940_- FIG00000453 45 12 46 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_73587_1_940_+ FIG00005860 10 5 11 SusD, outer membrane protein Cellulosome 1.x T2D_unique_73601_1_881_+ FIG00000279 176 29 178 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_73623_803_939_+ FIG00000175 9 2 10 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_73631_1_342_+ FIG00001904 93 14 93 Outer surface protein of unknown function, cellobiose operon Beta-Glucoside Metabolism 2.bc T2D_unique_73637_289_669_- FIG00010844 28 6 29 Flavodoxin Flavodoxin 1 T2D_unique_73639_69_545_- FIG00000542 84 16 85 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_73639_633_939_- FIG00002839 16 3 17 MutS-related protein, family 1 DNA repair, bacterial MutL-MutS system 1 T2D_unique_73704_107_490_- FIG00028461 32 8 34 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_73708_86_939_+ FIG00002718 48 12 49 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_73714_721_939_+ FIG00001712 13 5 14 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_73719_262_939_+ FIG00002470 36 8 39 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_73741_1_417_- FIG00000245 6 3 8 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_73741_493_939_- FIG00561498 6 3 8 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_73742_1_211_- FIG00000303 5 4 6 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_73750_1_618_+ FIG00001530 15 8 17 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_73776_436_938_- FIG00000372 6 2 6 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_73786_1_585_- FIG00000747 136 23 137 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_73788_687_938_- FIG00000126 35 6 36 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_73812_416_938_- FIG00001824 41 9 43 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_73839_1_938_+ FIG00059211 57 11 59 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_73887_1_925_+ FIG00038343 55 12 57 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_73889_1_937_+ FIG00745599 93 16 94 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_73894_1_523_- FIG00000304 7 3 9 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_73894_683_937_+ FIG00000355 18 4 20 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_73970_455_937_+ FIG00003955 127 19 127 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_73975_1_470_- FIG01304601 42 10 44 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_73975_482_937_- FIG00000782 35 7 36 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_73989_1_299_- FIG00109428 72 11 72 Probable 3-phenylpropionic acid transporter Flavohaemoglobin 1 T2D_unique_74055_137_310_+ FIG00016888 12 2 13 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_74081_1_227_+ FIG00000190 7 3 8 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_74084_1_509_- FIG00000877 121 19 121 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_74102_1_247_+ FIG00003596 6 2 7 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_74110_473_936_- FIG00015316 49 10 50 Flp pilus assembly protein TadB Widespread colonization island 2 T2D_unique_74166_552_935_- FIG00002470 5 2 7 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_74212_1_935_+ FIG00001036 93 20 94 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_74222_215_634_+ FIG00000621 12 5 14 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_74231_111_935_- FIG00001011 222 33 223 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_74271_1_934_+ FIG00004078 44 12 49 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_74293_653_934_+ FIG01297554 22 7 23 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_74304_624_934_+ FIG00001834 13 4 16 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_74318_1_232_- FIG00000341 53 9 53 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_74335_622_934_+ FIG00133229 14 5 15 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_74336_674_934_+ FIG00138258 64 10 64 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_74346_200_934_- FIG00000717 18 9 26 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_74354_725_934_+ FIG00000336 10 2 11 Cytosol aminopeptidase PepA (EC 3.4.11.1) EC 3.4.11.- Aminopeptidases 1 T2D_unique_74355_1_173_- FIG00000372 37 6 37 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_74356_1_221_- FIG00000190 26 5 27 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_74360_1_227_+ FIG00010738 53 8 53 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_74360_524_934_+ FIG00044478 81 14 93 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_74365_1_362_- FIG00001882 78 12 78 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_74384_573_934_+ FIG00000211 61 13 62 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_74387_1_277_- FIG00000258 38 7 39 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_74415_711_933_- FIG00000288 57 8 57 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_74438_1_473_- FIG00002541 79 14 80 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_74484_1_190_- FIG00060517 41 6 41 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_74484_656_933_- FIG00031250 63 10 63 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_74520_1_602_+ FIG00000756 149 23 150 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_unique_74536_1_348_- FIG00006032 3 2 5 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_74545_46_657_+ FIG00000408 102 19 104 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_74549_1_932_+ FIG00000116 232 36 232 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_74552_695_932_+ FIG00000527 49 8 49 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_74600_1_307_+ FIG01546819 69 11 69 TPP-requiring enzyme co-localized with putative O-antigen rfb gene cluster Acetoin, butanediol metabolism 5 T2D_unique_74629_1_405_+ FIG00000101 65 10 66 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_74648_1_708_+ FIG00137450 55 13 57 hypothetical protein PA3071 CBSS-345072.3.peg.1318 1 T2D_unique_74657_1_559_- FIG00000185 41 11 42 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_74668_132_931_+ FIG00008736 42 10 45 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_74697_1_279_+ FIG00042781 51 8 53 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_74697_400_931_+ FIG00001094 105 17 106 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_74747_786_931_+ FIG00000243 21 5 21 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_74758_440_634_+ FIG00015729 29 5 30 LSU ribosomal protein L29p (L35e) Ribosome LSU bacterial 9 T2D_unique_74768_202_732_+ FIG00004841 6 3 9 Stage III sporulation protein AG Sporulation Cluster III A 1.x T2D_unique_74768_749_931_+ FIG00013525 17 3 18 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_unique_74778_1_837_- FIG00001871 66 17 68 Glycerol-3-phosphate ABC transporter, permease protein UgpE (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_74784_641_930_- FIG00001221 7 4 9 Alkanesulfonates-binding protein Alkanesulfonates Utilization 20 T2D_unique_74786_1_195_+ FIG00005237 51 7 51 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_74792_145_504_- FIG00003655 83 13 83 PTS system, lactose-specific IIA component (EC 2.7.1.69) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_74792_514_930_- FIG00001011 119 16 119 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_74807_1_930_- FIG00028476 226 34 227 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_74827_1_185_- FIG00134342 4 2 5 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_74838_1_930_+ FIG00561498 36 5 38 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_74891_1_930_- FIG00019251 116 24 120 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_74898_123_930_+ FIG00000121 45 11 47 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_74918_436_929_+ FIG00001385 123 19 124 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_74923_392_859_+ FIG00018865 5 2 6 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_74943_304_929_- FIG00004078 25 6 27 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_74968_310_489_+ FIG00006632 43 7 43 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_unique_74976_1_265_- FIG00000402 29 7 30 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_75036_1_929_+ FIG00028694 12 5 16 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_75041_1_741_+ FIG00000395 182 27 183 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_75048_1_928_+ FIG01312219 184 32 185 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_unique_75066_1_347_- FIG00000207 80 13 80 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_75066_397_928_- FIG00000450 137 21 137 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_75073_1_317_- FIG00007957 73 11 73 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_75080_1_319_+ FIG00001358 87 13 87 Error-prone, lesion bypass DNA polymerase V (UmuC) DNA repair, bacterial UmuCD system 3 T2D_unique_75093_354_928_+ FIG00041038 38 11 39 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_75122_1_928_+ FIG00002251 39 12 55 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_75136_1_704_- FIG00000387 68 18 69 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_75176_1_521_- FIG00455853 68 13 69 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_75176_536_927_- FIG00945384 82 13 82 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_75178_1_579_- FIG00001253 58 9 60 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_75178_606_927_- FIG00000892 20 7 22 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_75209_1_162_- FIG00000402 3 2 5 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_75223_1_248_+ FIG00005728 13 3 14 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_75264_358_927_- FIG00000163 34 7 36 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_75295_82_900_+ FIG00033206 5 5 7 Enoyl-CoA hydratase (EC 4.2.1.17) Polyhydroxybutyrate metabolism 5.6 T2D_unique_75325_1_623_+ FIG01266244 41 9 42 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_75326_1_746_- FIG00003715 26 8 27 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_75329_1_818_- FIG00000539 214 32 214 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_75333_1_908_+ FIG00038920 11 4 12 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_75415_1_217_- FIG00021445 41 6 42 Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_75506_196_925_- FIG00001882 182 28 182 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_75541_1_797_+ FIG00009450 211 32 211 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_75574_313_924_- FIG01116805 166 23 166 Inducible Fructanase (EC 3.2.1.80), FruB Fructose and Mannose Inducible PTS 2 T2D_unique_75594_1_445_+ FIG00000166 63 13 64 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_75598_732_924_+ FIG00000860 49 7 49 O-succinylbenzoic acid--CoA ligase (EC 6.2.1.26) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_75615_628_924_- FIG00047056 4 2 11 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_75652_649_924_- FIG00002803 21 6 22 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_75686_1_388_- FIG01260980 16 6 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_75741_1_563_- FIG00000095 43 13 45 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_75775_1_598_+ FIG00000317 155 23 156 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_75785_1_923_- FIG00181043 21 10 39 Pullulanase (EC 3.2.1.41) Maltose and Maltodextrin Utilization 1.x T2D_unique_75794_714_923_+ FIG00000532 10 4 11 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_75821_519_923_- FIG00049915 103 16 103 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_75831_1_758_+ FIG00000025 21 9 23 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_75882_447_827_+ FIG00000164 94 15 94 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_unique_75885_642_922_- FIG00005860 77 11 77 SusD, outer membrane protein Cellulosome 1.x T2D_unique_75901_1_922_- FIG01260980 22 9 23 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_75916_1_176_+ FIG00045144 34 6 34 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_75916_347_922_+ FIG00047509 147 23 147 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_75920_205_922_- FIG00000362 10 3 11 Lipoate synthase Lipoic acid metabolism 5.0 T2D_unique_75923_1_922_- FIG00000146 160 27 161 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_75925_1_922_- FIG00017454 262 37 262 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_75936_1_922_+ FIG00060517 168 28 169 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_75947_1_793_- FIG00000350 7 7 10 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_75949_455_922_- FIG01260980 134 18 134 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_75958_39_921_- FIG00001548 42 10 44 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_75973_1_234_+ FIG00011114 56 9 57 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_75980_109_894_+ FIG00005727 3 3 6 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_76011_599_904_- FIG01318274 11 3 12 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_76015_631_921_+ FIG00085033 21 5 22 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_76021_1_921_+ FIG00000011 18 8 20 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_76032_621_921_+ FIG00561498 6 3 8 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_76038_1_277_- FIG00005022 6 3 9 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_76104_256_920_+ FIG00000001 12 9 20 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_76105_289_920_+ FIG00018369 61 13 62 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_76151_778_920_+ FIG00066575 11 3 12 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_76166_1_425_- FIG00006046 19 5 22 CRISPR-associated RAMP Csm3 CRISPR-associated cluster 1 T2D_unique_76174_391_920_+ FIG00000221 32 7 34 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_76203_462_893_+ FIG00000621 44 9 45 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_76218_652_919_- FIG00000411 9 4 10 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_76245_1_461_- FIG00000521 4 4 7 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_unique_76245_481_919_- FIG00001656 55 10 56 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_unique_76248_663_919_- FIG00001712 28 6 29 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_76285_1_205_+ FIG00000069 18 5 19 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_76296_1_449_- FIG00000040 82 15 84 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_76306_102_641_+ FIG00023019 32 10 33 Carbonic anhydrase (EC 4.2.1.1) Zinc regulated enzymes 1 T2D_unique_76318_318_593_- FIG00001563 18 6 18 Preprotein translocase subunit SecG (TC 3.A.5.1.1) Murein hydrolase regulation and cell death 1.2 T2D_unique_76322_679_919_+ FIG01298521 50 8 50 Lipoteichoic acid synthase LtaS Type IIb Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_76331_568_919_- FIG00070168 93 14 93 PTS system, fructose- and mannose-inducible IIB component (EC 2.7.1.69) Fructose and Mannose Inducible PTS 2 T2D_unique_76351_670_840_- FIG00000747 39 6 39 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_76382_1_339_- FIG00000420 6 4 8 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_76447_11_256_+ FIG00000315 59 9 59 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_76447_550_918_+ FIG00000458 92 13 92 Glycyl-tRNA synthetase alpha chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_76462_421_918_- FIG00007157 16 3 18 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_76486_1_375_+ FIG00007957 6 2 7 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_76543_1_414_+ FIG00049336 6 2 7 Foldase protein PrsA precursor (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_76609_1_137_- FIG00018561 19 4 19 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_76619_638_917_- FIG00003788 11 2 12 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_76636_1_388_+ FIG00010844 11 4 12 Flavodoxin Flavodoxin 1 T2D_unique_76668_1_916_- FIG00000114 121 26 124 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_76702_107_916_- FIG00006151 173 27 173 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_76710_1_260_+ FIG00133292 4 3 5 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_76729_457_916_- FIG00059426 33 9 35 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_76760_1_333_+ FIG00001489 8 3 9 ribosomal protein L7Ae family protein Transcription factors bacterial 1 T2D_unique_76760_353_916_+ FIG00000102 26 7 28 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_76774_1_889_+ FIG00001088 15 5 18 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_76793_328_633_- FIG00001224 3 2 5 Frataxin homolog CyaY, facilitates iron supply for heme A synthesis or Fe-S cluster assembly Biogenesis of cytochrome c oxidases 3 T2D_unique_76841_486_915_- FIG00000672 28 7 30 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_76845_339_599_+ FIG00006169 7 4 8 YoeB toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_76850_1_605_- FIG00008273 61 12 62 N-acetylneuraminate synthase (EC 2.5.1.56) Sialic Acid Metabolism 1.x T2D_unique_76873_602_915_+ FIG00090781 39 8 39 LSU ribosomal protein L14p (L23e) Ribosome LSU bacterial 9 T2D_unique_76890_1_245_+ FIG00006151 42 8 42 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_76898_656_915_+ FIG00003535 10 2 11 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_76926_472_914_- FIG00007957 95 15 97 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_76936_1_276_+ FIG00000440 17 5 18 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_unique_76995_1_914_+ FIG00000116 203 33 204 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_77011_176_412_+ FIG00018699 5 3 7 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_77036_1_281_+ FIG01292786 63 10 63 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_77088_29_913_- FIG00042267 15 8 18 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_77104_286_648_- FIG00145793 37 5 38 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase (EC 6.3.2.7) Peptidoglycan biosynthesis--gjo 1 T2D_unique_77145_1_329_- FIG00000011 64 11 65 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_77168_247_913_+ FIG00044622 158 22 160 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_77171_220_913_- FIG00001104 118 20 127 Arginine deiminase (EC 3.5.3.6) Arginine and Ornithine Degradation 1.34 T2D_unique_77193_1_646_+ FIG00000793 11 4 13 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_77203_706_912_+ FIG00001067 37 6 37 Rubrerythrin Oxidative stress 1.2 T2D_unique_77206_33_770_+ FIG00001824 36 12 39 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_77216_98_646_+ FIG00000087 20 7 22 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_77248_530_912_+ FIG00000990 12 4 15 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_77291_41_754_- FIG00000663 86 15 88 Pyridoxine 5'-phosphate synthase (EC 2.6.99.2) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_77301_1_912_- FIG00000578 138 25 140 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_77329_724_912_- FIG00059426 46 7 46 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_77348_28_489_- FIG00000573 27 8 28 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_unique_77349_1_911_- FIG00031250 81 15 83 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_77385_87_770_- FIG00007960 7 5 10 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_77393_1_911_+ FIG00000111 36 13 71 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_77429_528_911_- FIG00000343 13 4 15 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_77524_1_510_+ FIG00001522 9 3 11 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_77533_585_910_+ FIG00081311 19 5 20 rubredoxin-oxygen oxidoreductase Rubrerythrin 2 T2D_unique_77536_1_365_- FIG00016110 18 6 20 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_77536_479_910_- FIG00006551 12 3 13 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_77555_1_407_- FIG00002470 5 2 6 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_77565_102_910_- FIG00007137 10 4 13 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_77566_46_492_+ FIG00077620 31 6 32 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_77610_495_910_+ FIG00041038 46 9 48 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_77617_505_910_- FIG00148580 36 6 37 Penicillin-insensitive transglycosylase (EC 2.4.2.-) & transpeptidase PBP-1C Peptidoglycan Biosynthesis 1.9 T2D_unique_77621_1_910_+ FIG00026918 19 7 22 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_77654_1_870_+ FIG01260980 112 21 113 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_77656_1_716_+ FIG00034392 129 23 131 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_77666_754_909_- FIG00037431 32 5 32 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_77717_1_909_- FIG00052730 231 35 233 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_77719_1_909_+ FIG00000038 13 4 14 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_77724_521_909_+ FIG00009149 92 14 92 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_77738_1_524_+ FIG00000350 33 9 34 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_77738_544_909_+ FIG00024401 17 7 21 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_77745_591_909_+ FIG00075702 25 8 27 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_77760_390_908_+ FIG00000101 82 15 83 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_77807_519_908_+ FIG00002716 91 15 91 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_77810_202_908_+ FIG00125395 132 20 133 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_77830_412_908_- FIG00001384 5 3 8 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_77850_1_384_+ FIG00038343 8 2 9 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_77868_340_555_- FIG00004099 8 2 9 Regulatory protein RecX RecA and RecX 1 T2D_unique_77890_62_908_- FIG00133005 11 5 13 Lysophospholipase L2 (EC 3.1.1.5) Triacylglycerol metabolism 7 T2D_unique_77914_1_249_- FIG00000279 14 3 15 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_77917_659_907_- FIG00001753 41 8 42 Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-) Acetoin, butanediol metabolism 5 T2D_unique_77945_1_248_- FIG00000211 28 6 29 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_77955_147_907_- FIG00000721 10 4 12 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_77967_714_907_+ FIG00130344 13 4 14 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_78070_146_649_+ FIG01304818 20 10 49 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_78072_1_243_- FIG00000401 35 7 36 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_78074_4_180_- FIG00001099 39 6 39 S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) Glutathione-dependent pathway of formaldehyde detoxification 1 T2D_unique_78103_1_906_+ FIG00000085 243 35 244 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_78114_505_741_+ FIG00077620 68 9 68 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_78128_1_565_+ FIG00001269 99 18 101 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_78132_350_906_+ FIG00000252 13 5 15 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_78166_1_358_+ FIG00001059 7 3 8 TolA protein Ton and Tol transport systems 2 T2D_unique_78213_149_905_+ FIG01260980 128 21 129 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_78243_256_905_+ FIG01307086 101 17 101 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_78246_717_866_+ FIG00001168 9 3 10 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_78258_72_905_+ FIG00004763 6 5 8 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_78283_1_754_+ FIG00000491 72 15 77 Queuosine Biosynthesis QueC ATPase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_78288_1_380_- FIG00000405 41 7 42 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_78362_1_215_+ FIG01473072 50 8 50 Predicted glycerol-1-phosphate dehydrogenase, arabinose operon L-Arabinose utilization 1 T2D_unique_78383_1_904_- FIG00075970 5 3 9 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_78404_392_904_+ FIG00000420 76 14 76 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_78410_549_904_- FIG00010738 22 6 24 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_78412_2_904_- FIG00044622 178 28 179 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_78416_1_167_- FIG00000001 13 2 14 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_78509_1_314_- FIG00038461 85 12 85 Putative deoxyribonuclease YjjV Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_78529_399_737_+ FIG00004021 32 7 33 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_78543_1_774_- FIG01007502 45 13 50 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_78548_1_616_+ FIG00029916 162 24 162 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_78560_1_590_- FIG00052730 14 6 16 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_78574_1_424_- FIG00008736 24 5 25 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_78582_688_902_+ FIG00000532 21 6 22 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_78586_1_371_- FIG00000279 43 8 44 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_78591_1_156_- FIG00000329 33 5 34 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_78640_1_410_- FIG00001834 16 5 18 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_78644_676_902_- FIG00067300 60 9 60 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_78731_530_901_- FIG00000190 12 5 13 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_78764_77_883_- FIG00012945 31 9 39 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_78776_689_901_+ FIG00001750 49 8 49 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_78791_1_144_+ FIG00846773 30 5 30 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_78811_329_901_+ FIG00229386 14 5 18 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_78847_1_162_+ FIG00000259 30 4 31 LSU ribosomal protein L35p Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins) 1 T2D_unique_78851_1_217_+ FIG00034293 27 4 28 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_78863_70_615_+ FIG00000408 47 11 49 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_78866_1_205_+ FIG00004296 36 5 38 Amino acid-binding ACT Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_78881_1_359_+ FIG00000193 27 6 28 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_unique_78888_1_451_+ FIG00001712 27 8 29 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_78890_1_403_- FIG00002300 5 4 7 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_78904_1_195_+ FIG00000408 51 7 51 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_78910_1_861_+ FIG00000842 18 6 20 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_78913_731_900_+ FIG00000355 21 4 22 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_78924_164_900_+ FIG00000329 109 21 112 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_78926_572_751_+ FIG00000409 47 7 47 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_unique_78926_754_900_+ FIG00000166 34 5 34 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_78949_1_548_- FIG00521220 39 11 41 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_78982_488_899_+ FIG00000402 22 5 24 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_79028_338_899_+ FIG01239241 8 4 9 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_79037_364_899_- FIG00719736 3 2 5 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_79093_1_899_+ FIG00006955 27 8 29 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_79114_1_229_- FIG00000521 4 2 5 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_unique_79178_1_898_- FIG01260980 3 2 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_79184_1_716_- FIG00001366 6 5 8 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_79218_1_898_- FIG01960485 9 7 12 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_79265_86_367_- FIG00000224 13 3 15 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_79282_765_897_+ FIG00002049 3 3 5 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_79297_1_897_- FIG00075702 105 21 106 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_79309_1_420_+ FIG00006691 3 3 5 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_79311_1_368_+ FIG00000095 32 8 33 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_79313_249_566_- FIG00000177 30 7 31 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_79319_499_897_+ FIG00089781 69 11 70 Possible alpha-xyloside ABC transporter, permease component Xylose utilization 1 T2D_unique_79326_289_897_+ FIG00002130 146 22 147 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_79360_1_815_- FIG00745599 108 21 110 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_79370_161_897_- FIG00001547 21 4 22 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_79414_15_896_- FIG00000555 95 20 96 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_79419_147_896_- FIG00001824 49 13 51 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_79455_1_553_- FIG00000289 36 12 39 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_79502_1_170_+ FIG00005172 3 2 4 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_79546_130_895_+ FIG01304229 65 13 66 MSM (multiple sugar metabolism) operon regulatory protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_79563_1_824_- FIG00047414 104 19 106 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_79570_763_895_- FIG00001548 4 2 5 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_79571_1_188_- FIG00001469 31 5 31 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_79586_1_895_- FIG00000243 231 35 231 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_79606_1_719_- FIG00000156 98 18 99 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_79663_377_894_- FIG00051439 10 6 28 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_79727_131_493_+ FIG00554193 9 3 11 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_79800_261_893_- FIG00138354 4 4 7 Alkanesulfonates transport system permease protein Alkanesulfonates Utilization 20 T2D_unique_79802_174_851_+ FIG00005797 144 24 145 Lipoteichoic acid synthase LtaS Type IIc Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_79822_1_230_+ FIG00041819 23 4 24 N-acylglucosamine 2-epimerase (EC 5.1.3.8) Sialic Acid Metabolism 1.x T2D_unique_79829_394_893_- FIG00001676 4 4 7 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_79835_1_893_+ FIG00016514 53 16 54 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_79890_623_893_+ FIG00000107 70 10 70 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_79899_1_893_+ FIG00001307 13 6 17 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_unique_79907_1_401_- FIG00945384 4 4 6 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_79917_526_893_+ FIG00006128 22 5 24 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_79936_1_508_- FIG00000177 142 20 142 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_79961_230_892_- FIG00029916 171 26 171 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_79981_499_892_- FIG00000223 14 2 16 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_80043_1_892_+ FIG00030191 5 3 8 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_80084_210_368_+ FIG00019251 39 6 39 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_80153_273_891_- FIG00021517 141 21 142 Cell division protein FtsQ Cell Division Cluster 1.x T2D_unique_80192_1_485_+ FIG00000070 28 8 30 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_80229_719_891_+ FIG00000076 34 6 34 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_80250_661_890_+ FIG00001189 40 6 40 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_80278_664_890_+ FIG00000377 11 2 12 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_80296_1_890_+ FIG00006463 5 3 8 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_80319_1_388_- FIG00003435 96 15 96 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_80336_1_228_- FIG00011468 10 3 11 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_80344_7_396_- FIG00003769 81 13 81 Stage III sporulation protein AE Sporulation Cluster III A 1.x T2D_unique_80345_1_744_- FIG00000370 35 12 37 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_80385_495_889_+ FIG00719736 93 15 93 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_80421_251_700_+ FIG00000312 109 17 109 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_80449_1_217_- FIG00058830 8 4 20 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_80473_332_889_- FIG00000149 25 7 26 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_80497_1_793_- FIG00001653 215 31 215 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_80507_438_889_+ FIG00000187 78 14 79 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_80509_1_537_+ FIG00000584 72 15 74 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_80541_1_447_- FIG00000256 59 12 60 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_80567_1_393_+ FIG00000176 102 14 102 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_80594_77_547_- FIG00000494 6 3 7 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_80597_436_888_+ FIG00000422 42 12 43 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_80753_478_887_+ FIG00030688 59 11 60 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_80770_1_295_- FIG00000775 69 10 70 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_80770_462_887_- FIG00000897 21 6 23 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_80795_681_887_- FIG00229360 23 5 24 Tagatose-6-phosphate kinase (EC 2.7.1.144) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_80860_1_297_+ FIG00001834 5 3 11 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_80866_148_886_- FIG00001280 28 7 30 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_80916_1_886_- FIG00000834 84 13 84 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_80920_348_886_+ FIG00066575 11 4 22 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_80929_363_886_- FIG00475203 48 10 49 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_80994_1_755_- FIG00003460 209 30 209 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_80998_133_885_- FIG00030183 204 29 204 Chondroitinase (chondroitin lyase) N-Acetyl-Galactosamine and Galactosamine Utilization B.x T2D_unique_81018_161_885_- FIG00000175 21 4 23 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_81023_266_496_+ FIG00000234 9 3 11 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_81028_433_885_- FIG00000376 24 6 28 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_81031_542_885_+ FIG01956356 7 2 8 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_81036_1_407_+ FIG00000636 43 12 44 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_81051_1_885_- FIG00007957 151 25 151 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_81054_436_885_+ FIG00034293 3 2 5 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_81111_1_885_- FIG00013626 233 34 234 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_81112_1_845_- FIG00008507 223 34 223 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_81118_1_704_+ FIG00000527 192 27 192 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_81136_44_884_- FIG00047414 19 9 21 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_81138_469_884_+ FIG00001656 102 16 102 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_unique_81186_532_884_+ FIG00001893 18 6 21 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_81188_1_402_+ FIG00031250 87 14 88 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_81196_118_884_- FIG00000412 73 14 75 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_81200_68_884_+ FIG00049808 197 28 198 Choline binding protein D Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_81264_1_462_+ FIG00116638 17 6 18 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_81294_1_262_+ FIG00000960 64 10 64 Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_81312_487_883_- FIG00000116 29 5 30 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_81366_1_686_- FIG00001170 6 3 8 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_unique_81366_740_883_- FIG00000101 6 2 7 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_81369_1_883_- FIG00000287 235 35 235 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_81371_1_883_- FIG00136692 173 29 176 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_81378_556_883_+ FIG00000148 45 9 46 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_81380_1_841_+ FIG00018699 31 8 36 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_81390_345_883_+ FIG00001208 21 4 22 [NiFe] hydrogenase metallocenter assembly protein HypD NiFe hydrogenase maturation 1 T2D_unique_81402_17_883_+ FIG00007957 103 19 104 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_81406_695_883_+ FIG00000913 9 2 10 Ribonuclease E (EC 3.1.26.12) RNA processing and degradation, bacterial 1 T2D_unique_81429_486_882_- FIG00060294 7 2 9 ABC transport system, permease component YbhS ATP-dependent efflux pump transporter Ybh 1 T2D_unique_81436_1_851_+ FIG00002818 230 34 230 Inner membrane protein translocase component YidC, long form Cell Division Subsystem including YidCD 1 T2D_unique_81492_1_882_- FIG00048014 35 10 63 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_81532_1_166_- FIG00000308 34 6 34 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_81532_216_446_- FIG00001563 47 8 47 Preprotein translocase subunit SecG (TC 3.A.5.1.1) Murein hydrolase regulation and cell death 1.2 T2D_unique_81552_1_563_+ FIG00000594 127 19 128 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_81553_1_444_- FIG00134889 19 4 21 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_81554_235_882_- FIG00138209 21 5 27 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_81604_240_881_+ FIG00009775 29 9 33 Glycosyl transferase, group 1 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_81610_1_881_+ FIG00067681 76 19 114 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_81612_695_881_+ FIG00010414 44 6 44 ComF operon protein A, DNA transporter ATPase Gram Positive Competence 3100 T2D_unique_81649_1_731_- FIG00041038 193 29 193 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_81675_1_181_- FIG00000267 5 3 6 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_81675_186_881_- FIG00000404 95 15 96 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_81680_753_881_- FIG00001522 10 2 11 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_81738_514_880_+ FIG00013339 93 14 93 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_81740_496_880_+ FIG01260980 9 4 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_81755_1_186_+ FIG00000001 45 7 45 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_81794_1_559_+ FIG00051439 28 8 31 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_81803_1_513_- FIG00021289 122 19 123 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_81853_420_880_+ FIG00000308 99 15 100 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_81854_565_880_+ FIG00001469 11 4 12 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_81887_297_701_- FIG01260980 6 2 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_81918_65_496_- FIG00001547 6 3 8 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_81948_185_879_+ FIG00042267 4 3 6 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_81995_1_838_+ FIG00000207 36 9 39 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_82006_305_879_+ FIG00004764 44 9 46 Ammonium transporter Ammonia assimilation 1 T2D_unique_82012_1_879_- FIG00108342 114 21 116 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_82021_1_878_+ FIG00000402 61 15 64 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_82042_1_641_+ FIG00081563 133 20 134 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_82046_376_878_- FIG00010738 51 13 53 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_82087_590_878_- FIG00000477 26 5 27 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_82136_464_878_+ FIG00008490 68 12 69 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_82140_714_878_- FIG00000121 20 4 23 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_82161_1_226_- FIG00002541 24 6 26 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_82170_115_618_+ FIG00003555 9 4 11 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_82187_1_877_- FIG00000011 53 16 56 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_82188_1_193_+ FIG00000522 38 7 38 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_82194_1_877_+ FIG00000117 191 28 192 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_82204_257_877_- FIG00003439 23 8 25 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_82237_500_877_+ FIG01260980 10 5 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_82247_1_589_- FIG00000446 117 20 118 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_82247_627_877_- FIG00021289 52 9 52 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_82276_254_604_+ FIG00001182 5 3 7 [NiFe] hydrogenase nickel incorporation protein HypA NiFe hydrogenase maturation 1 T2D_unique_82288_1_611_- FIG00000441 20 5 21 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_82298_456_877_- FIG00137824 102 16 102 Iron compound ABC uptake transporter substrate-binding protein PiuA Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_82304_1_379_- FIG00001653 52 9 52 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_82341_1_799_+ FIG00001311 53 11 55 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_unique_82370_1_723_- FIG00004308 39 11 42 N-acetylglucosamine related transporter, NagX Chitin and N-acetylglucosamine utilization 2 T2D_unique_82399_283_792_+ FIG00000430 41 8 43 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_unique_82408_73_876_- FIG00018699 25 12 27 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_82415_1_549_+ FIG00036406 31 10 32 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_82456_38_805_+ FIG01260980 171 26 172 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_82462_476_876_- FIG00000370 79 14 80 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_82498_1_575_- FIG00015014 5 2 9 Coenzyme F420-dependent oxidoreductase Anaerobic respiratory reductases 3 T2D_unique_82505_588_839_+ FIG00054459 6 3 7 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_82514_515_876_- FIG00000190 69 12 74 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_82530_517_876_+ FIG00035634 92 13 92 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_82540_145_875_+ FIG00000636 140 26 141 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_82542_1_875_- FIG00000356 31 9 34 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_82550_1_560_+ FIG00005873 135 19 136 PTS system, galactose-specific IIC component (EC 2.7.1.69) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_82573_238_816_+ FIG00019508 15 4 17 Phage major tail protein Phage tail proteins 2 4 T2D_unique_82592_1_344_+ FIG00000198 27 8 28 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_82592_383_772_+ FIG00000174 41 8 42 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_unique_82608_1_154_+ FIG00002049 34 5 34 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_82608_172_875_+ FIG00018865 100 19 102 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_82624_532_875_- FIG00051882 19 5 21 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Cobalamin synthesis 2 T2D_unique_82630_1_360_+ FIG01260980 102 14 102 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_82676_343_585_+ FIG00007753 8 2 9 Transition state regulatory protein AbrB Poly-gamma-glutamate biosynthesis 3 T2D_unique_82680_1_875_+ FIG00000504 222 32 230 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_82691_1_153_+ FIG01239241 6 2 7 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_82713_1_311_+ FIG00000397 14 3 16 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_82723_119_754_+ FIG00040371 60 10 62 Iron-dependent repressor IdeR/DtxR Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_82729_1_344_+ FIG00000477 5 3 6 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_82747_1_874_+ FIG00052730 26 9 33 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_82796_1_552_+ FIG00136193 35 10 38 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_82811_147_874_- FIG00075702 80 19 81 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_82868_271_874_+ FIG00042627 71 11 73 Magnesium and cobalt efflux protein CorC Copper homeostasis: copper tolerance 3 T2D_unique_82898_1_873_+ FIG00067681 236 34 237 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_82971_1_627_+ FIG00000076 111 18 112 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_83024_164_751_+ FIG01303822 139 21 139 Hypothetical protein VC0266 (sugar utilization related?) VC0266 1 T2D_unique_83039_1_872_- FIG00000863 15 8 19 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_83063_329_872_+ FIG00000865 55 11 56 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_83088_2_343_- FIG00001862 25 7 26 L-rhamnose mutarotase L-rhamnose utilization 1 T2D_unique_83093_1_287_- FIG00005283 44 9 45 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_83131_1_828_- FIG00451095 65 15 67 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_83136_1_872_+ FIG00459778 198 32 199 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_83161_1_472_+ FIG00025759 48 11 49 Orotate phosphoribosyltransferase (EC 2.4.2.10) De Novo Pyrimidine Synthesis 1 T2D_unique_83161_555_872_+ FIG00037431 20 5 21 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_83178_345_872_+ FIG00001402 41 10 43 Helicase loader DnaI DNA-replication 4 T2D_unique_83223_622_871_+ FIG00000256 37 7 38 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_83229_690_871_- FIG00000426 10 2 11 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY Bacterial Chemotaxis 9 T2D_unique_83244_322_871_- FIG00001522 61 12 63 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_83300_1_871_+ FIG00000402 224 34 225 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_83310_336_686_+ FIG00008572 3 3 5 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_83318_1_153_+ FIG00000387 12 3 13 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_83329_1_871_+ FIG00001076 205 33 205 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_83363_1_832_- FIG00001547 25 6 27 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_83403_316_870_- FIG01318398 12 3 14 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_83457_1_870_- FIG00075702 239 34 239 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_83489_302_763_+ FIG00000313 49 10 51 Catalase (EC 1.11.1.6) Oxidative stress 1.2 T2D_unique_83513_1_476_- FIG00008941 12 4 13 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_83521_1_869_- FIG00067681 219 34 219 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_83559_42_869_- FIG00000025 8 5 11 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_83568_1_869_- FIG00024930 68 15 70 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_83576_1_218_+ FIG00058830 32 6 33 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_83581_501_869_+ FIG00000372 21 7 23 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_83660_476_869_- FIG00138538 30 7 32 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_83720_1_868_- FIG00026918 89 20 91 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_83744_1_689_+ FIG00019868 14 2 16 Maltose/maltodextrin ABC transporter, permease protein MalF Maltose and Maltodextrin Utilization 1.x T2D_unique_83758_1_868_- FIG00136692 194 29 199 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_83761_1_868_+ FIG00000087 26 13 61 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_83776_1_134_+ FIG00005727 21 4 22 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_83791_1_868_- FIG00000402 79 17 80 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_83840_1_336_+ FIG00149566 7 2 9 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_83840_372_867_+ FIG01271998 42 13 43 Possible hypoxanthine oxidase XdhD (EC 1.-.-.-) Purine conversions 4.1118100 T2D_unique_83855_1_279_- FIG00000721 20 3 22 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_83867_1_838_+ FIG00000504 128 23 130 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_83880_1_200_+ FIG00000445 46 7 46 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_83960_84_867_- FIG00000279 67 16 69 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_83988_114_638_- FIG00003460 39 7 40 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_84010_1_636_+ FIG00001907 23 7 25 Glycerol uptake operon antiterminator regulatory protein Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_84055_296_866_+ FIG00019251 8 2 9 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_84062_1_371_- FIG00000098 88 14 88 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_84068_1_866_+ FIG00001189 148 26 149 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_84099_1_866_- FIG00000070 97 15 99 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_84106_297_866_- FIG00000838 64 10 67 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_84125_1_488_+ FIG00000241 58 11 60 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_84145_1_142_+ FIG00001569 38 5 38 LysR family regulatory protein CidR Murein hydrolase regulation and cell death 1.2 T2D_unique_84158_1_582_+ FIG00136866 65 12 67 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_84162_1_407_- FIG00001088 47 12 48 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_84168_222_865_- FIG00004453 25 6 27 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_84197_176_724_- FIG00001067 123 20 123 Rubrerythrin Oxidative stress 1.2 T2D_unique_84228_1_300_- FIG00000402 59 11 59 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_84229_607_865_+ FIG00000762 35 7 37 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_84273_662_865_- FIG00003530 47 7 48 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_84284_1_865_+ FIG00000391 46 13 78 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_84374_1_315_- FIG00000402 57 10 58 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_84394_415_864_- FIG00000242 114 17 114 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_84413_1_221_- FIG00008656 50 8 50 Regulatory protein (induces abgABT, used to catabolize p-aminobenzoyl-glutamate) p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_84455_1_438_- FIG00002194 61 11 63 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_84455_467_863_- FIG00000164 93 15 93 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_unique_84472_547_863_+ FIG00022300 8 2 9 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_84481_1_453_- FIG00048014 48 11 51 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_84602_344_862_- FIG00018396 36 11 39 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_84676_570_862_+ FIG00059413 51 10 51 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL Dihydroxyacetone kinases 3 T2D_unique_84682_16_862_- FIG00001548 233 33 234 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_84693_605_862_- FIG01031896 12 4 13 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_84697_1_862_- FIG00000279 205 33 205 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_84699_493_862_- FIG00061313 7 4 9 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_84732_1_330_+ FIG00719736 16 6 18 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_84773_591_861_+ FIG01304195 59 9 59 ABC transporter involved in cytochrome c biogenesis, ATPase component CcmA Biogenesis of c-type cytochromes 1.1 T2D_unique_84774_646_861_- FIG00000216 37 7 38 LSU ribosomal protein L20p Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins) 1 T2D_unique_84812_1_861_- FIG00060517 44 11 46 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_84822_1_675_- FIG00007714 55 13 57 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_84826_1_411_+ FIG00001547 5 2 7 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_84834_340_861_- FIG00000148 101 17 103 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_84848_1_861_+ FIG00136922 149 27 151 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_84930_1_806_- FIG00000477 121 23 122 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_84934_1_482_+ FIG00000391 5 3 14 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_84949_651_860_- FIG00129130 22 6 23 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_84952_1_860_+ FIG00000011 10 5 12 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_84960_575_860_+ FIG00000121 3 2 4 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_85031_1_177_+ FIG00000089 14 4 16 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_85044_1_450_+ FIG00108342 31 9 33 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_85047_1_447_+ FIG00000190 89 14 91 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_85099_1_626_- FIG00024851 149 24 150 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_85099_704_859_- FIG00013638 28 5 28 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_85181_4_438_- FIG00001980 22 4 24 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_85188_1_751_- FIG00129130 18 7 21 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_85197_1_858_+ FIG00067681 29 9 31 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_85208_1_858_- FIG00000243 61 14 63 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_85209_1_858_+ FIG00000402 198 32 198 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_85224_1_456_+ FIG00134135 48 11 50 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_85257_1_597_+ FIG00010508 63 13 64 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_85257_619_858_+ FIG00000328 14 5 15 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_85271_1_234_+ FIG00009194 19 5 20 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_85289_1_858_- FIG01260980 245 34 246 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_85333_1_751_- FIG00059211 4 4 9 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_85365_40_321_- FIG00009229 26 5 27 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_85371_1_857_+ FIG00010454 110 20 112 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_85372_134_857_- FIG00001824 60 15 62 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_85380_1_250_- FIG00002487 60 9 60 Heptaprenyl diphosphate synthase component II (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_85400_1_430_+ FIG00001436 26 5 28 GlpG protein (membrane protein of glp regulon) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_85428_1_857_- FIG00475203 17 6 19 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_85429_19_857_+ FIG00001401 36 10 37 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_85447_194_857_+ FIG00005243 4 2 6 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_85459_1_186_- FIG00121768 36 7 36 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_85461_597_857_+ FIG00000245 39 6 40 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_85507_1_856_- FIG00002968 70 16 74 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_85522_1_210_- FIG00000184 5 2 7 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_85532_1_524_+ FIG00001548 16 3 18 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_85536_95_760_+ FIG00006092 5 4 9 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_85542_1_771_+ FIG00001518 21 8 24 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_85548_1_388_- FIG00000001 32 8 33 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_85555_1_139_- FIG00012498 26 5 26 Uracil-DNA glycosylase family protein, clostridial type Uracil-DNA glycosylase 1 T2D_unique_85580_1_856_- FIG00001547 72 15 74 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_85583_191_856_- FIG00437351 8 7 20 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_unique_85611_1_761_- FIG00001129 65 16 67 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_unique_85615_1_856_+ FIG00000317 51 13 53 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_85616_186_856_+ FIG00057709 28 7 33 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_85645_1_361_- FIG00049433 33 10 34 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_85659_1_623_+ FIG00000370 132 20 133 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_85661_448_855_+ FIG00086697 4 2 6 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_85672_445_855_- FIG00000441 102 16 102 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_85682_1_855_- FIG00046929 4 5 8 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_85686_1_324_+ FIG00000132 3 3 4 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_85693_646_855_- FIG00000235 36 7 36 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_85708_1_307_+ FIG00022899 8 3 10 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_85742_296_855_+ FIG00031969 12 4 17 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_85800_1_542_- FIG00139735 144 20 144 fructose sensor histidine kinase Fructose and Mannose Inducible PTS 2 T2D_unique_85801_514_854_- FIG00001712 24 7 25 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_85807_1_854_+ FIG00020613 16 3 18 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_85818_1_584_- FIG00000107 160 22 160 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_85840_225_854_- FIG01304601 3 3 6 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_85847_526_854_+ FIG00002239 78 12 79 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_85877_1_776_- FIG00064110 99 22 101 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_85886_1_333_+ FIG00023369 48 10 49 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_85906_1_192_- FIG00002049 26 5 26 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_85924_320_854_- FIG00001505 51 14 54 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_85926_1_205_- FIG00001546 58 8 58 Poly(glycerophosphate chain) D-alanine transfer protein DltD D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_85932_1_854_+ FIG00044622 40 7 42 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_85994_1_853_+ FIG00561498 141 23 142 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_85998_1_753_- FIG00001311 26 8 34 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_unique_86056_254_631_- FIG00004763 33 6 34 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_86068_240_853_+ FIG00000088 96 16 98 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_86122_1_852_+ FIG00001166 46 14 49 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_86181_1_700_- FIG00000494 73 13 74 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_86217_1_852_- FIG00018369 79 21 84 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_86256_339_852_+ FIG00000040 141 20 141 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_86262_126_852_+ FIG00006997 8 3 10 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_86280_1_285_- FIG00001562 82 11 82 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_unique_86282_572_852_- FIG00000011 23 5 24 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_86298_1_852_- FIG00000434 179 29 181 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_86310_1_221_- FIG00051957 11 3 12 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_86310_601_851_+ FIG00000641 19 4 20 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_86364_1_851_- FIG00000539 169 28 171 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_86370_1_851_+ FIG00028461 72 19 74 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_86380_1_503_+ FIG00006945 130 19 130 Anaerobic sulfite reductase subunit B Anaerobic respiratory reductases 3 T2D_unique_86380_517_851_+ FIG00009014 83 13 83 Anaerobic sulfite reductase subunit C (EC 1.8.1.-) Anaerobic respiratory reductases 3 T2D_unique_86394_219_578_- FIG00000967 100 14 100 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_unique_86394_580_851_- FIG00009156 77 11 77 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_86397_1_851_- FIG00000338 33 10 51 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_86404_1_851_- FIG00745599 58 15 59 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_86411_1_588_- FIG00093180 13 5 15 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_86477_1_668_+ FIG00067681 26 5 28 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_86491_1_850_+ FIG00005698 8 3 10 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_86498_1_850_+ FIG00000176 112 24 113 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_86508_295_850_+ FIG00001198 29 9 31 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_86605_1_850_+ FIG00000732 36 9 38 Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11) Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_86614_1_850_- FIG00021289 50 16 112 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_86627_531_850_+ FIG00451095 66 11 66 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_86640_1_850_+ FIG00024073 48 11 50 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_86655_570_849_+ FIG00016566 75 11 75 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_86686_1_849_+ FIG00000176 144 25 146 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_86711_1_276_+ FIG00057709 75 11 75 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_86744_460_849_- FIG00021289 3 2 4 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_86779_706_849_+ FIG01290464 36 5 36 Flagellar motor switch protein FliM Bacterial Chemotaxis 9 T2D_unique_86808_206_849_+ FIG00000762 15 4 17 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_86823_298_848_- FIG00035634 21 5 23 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_86827_1_293_- FIG00003381 66 11 66 L-cystine uptake protein TcyP L-Cystine Uptake and Metabolism 6.0 T2D_unique_86863_1_716_+ FIG00000401 161 24 163 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_86894_287_808_+ FIG00004229 12 5 14 Heptaprenyl diphosphate synthase component I (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_86920_169_848_+ FIG00016145 153 25 153 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_unique_86972_1_848_+ FIG00034851 133 24 135 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_86982_1_597_- FIG00030585 23 5 25 Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_86999_371_847_- FIG00004589 121 18 121 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_87002_1_847_- FIG00018457 3 3 5 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_87004_1_847_- FIG00024930 40 12 41 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_87020_575_847_+ FIG00000430 24 5 25 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_unique_87025_1_265_+ FIG01304225 66 10 67 Phage tail fibers Phage tail fiber proteins 2 T2D_unique_87035_1_525_+ FIG01260980 67 13 68 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_87073_1_847_- FIG00000268 136 27 137 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_87107_293_847_+ FIG00106663 139 21 139 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_87155_1_191_- FIG00000408 12 3 12 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_87167_1_846_- FIG00028203 198 30 198 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_87183_1_561_- FIG00022899 123 20 123 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_87188_1_846_- FIG00046929 6 4 9 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_87210_288_846_+ FIG00000332 81 15 82 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_87233_187_846_+ FIG00000467 148 23 149 Biotin synthase (EC 2.8.1.6) Biotin biosynthesis 1X T2D_unique_87250_450_791_+ FIG00002541 23 5 24 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_87277_659_846_- FIG00001499 15 3 16 GTP-binding protein YqeH, required for biogenesis of 30S ribosome subunit Universal GTPases 2 T2D_unique_87280_1_253_+ FIG00000414 9 3 11 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_87358_1_263_+ FIG00000141 38 8 38 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_87368_1_365_- FIG00015833 14 3 16 Oligosaccharide repeat unit polymerase Wzy Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_87421_1_145_+ FIG00135025 9 3 10 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_87434_625_845_- FIG00038814 28 6 29 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_87491_1_845_- FIG00022899 99 20 100 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_87514_1_594_+ FIG00047056 65 11 67 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_87515_1_845_- FIG00033847 42 11 44 Na(+)-translocating NADH-quinone reductase subunit B (EC 1.6.5.-) Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_87554_252_844_+ FIG00000997 16 6 18 Protein RtcB RNA 3'-terminal phosphate cyclase 2 T2D_unique_87625_1_374_- FIG00059124 9 4 10 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_87625_582_844_- FIG00000146 3 2 4 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_87651_1_318_+ FIG01312219 31 7 33 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_unique_87664_1_257_- FIG00000494 7 3 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_87666_1_844_- FIG00006128 191 30 191 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_87683_1_492_+ FIG00001385 106 16 107 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_87684_42_383_- FIG00000494 21 4 22 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_87696_692_843_+ FIG00001882 9 2 10 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_87700_217_363_- FIG00079822 14 4 16 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_87711_125_843_+ FIG00132839 114 18 116 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_87713_58_843_- FIG00719736 200 29 200 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_87714_102_843_+ FIG00133209 95 17 96 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_87745_121_843_+ FIG00003894 170 28 170 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_87757_1_843_- FIG00031250 94 19 96 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_87787_1_338_+ FIG00046358 11 2 12 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_87790_520_843_- FIG00005172 87 12 87 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_87818_427_843_- FIG00001366 3 3 5 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_87842_1_589_- FIG00000782 80 17 81 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_87871_1_786_+ FIG00002470 52 11 54 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_87898_1_842_- FIG00080955 121 23 123 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_87924_29_784_+ FIG00000126 83 17 85 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_87932_1_461_+ FIG00000822 8 4 10 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_87948_1_392_+ FIG00022300 16 5 19 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_88001_1_419_- FIG00136522 4 2 5 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_unique_88028_1_842_+ FIG00004074 22 11 24 Ferredoxin-type protein NapG (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_88029_1_842_- FIG00000395 72 16 76 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_88049_1_228_+ FIG01260980 10 3 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_88134_143_841_- FIG00018865 9 6 12 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_88177_1_841_+ FIG00000578 178 30 180 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_88218_1_840_- FIG00028203 78 19 79 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_88242_1_277_- FIG00006997 54 9 54 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_88247_1_203_+ FIG00133226 5 2 7 Dihydrolipoamide dehydrogenase of acetoin dehydrogenase (EC 1.8.1.4) Acetoin, butanediol metabolism 5 T2D_unique_88283_440_840_+ FIG00103661 19 7 21 Transcriptional regulator, MerR family, near polyamine transporter Polyamine Metabolism 2 T2D_unique_88291_1_840_+ FIG00010194 87 17 89 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_88298_66_840_- FIG00001364 49 11 51 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Glycine and Serine Utilization 1.12 T2D_unique_88337_1_840_+ FIG00028203 193 29 193 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_88373_1_364_+ FIG00003394 17 5 18 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_88377_371_839_- FIG00000834 52 8 53 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_88385_1_701_- FIG00000168 175 26 176 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_88393_518_839_+ FIG00007073 7 2 9 Exopolysaccharide biosynthesis glycosyltransferase EpsF (EC 2.4.1.-) Exopolysaccharide Biosynthesis 1.0 T2D_unique_88402_317_839_- FIG00008941 26 8 27 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_88406_160_839_+ FIG01304276 162 25 162 Cystathionine beta-lyase (EC 4.4.1.8) Methionine Biosynthesis 8 T2D_unique_88410_243_839_- FIG00028461 41 9 42 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_88412_1_211_+ FIG00000309 16 5 18 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_88443_185_839_- FIG00094401 90 14 91 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_88455_85_839_- FIG00034392 25 6 27 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_88456_1_783_+ FIG00001676 4 2 6 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_88460_180_839_- FIG00000899 183 26 183 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_88469_1_839_- FIG00044622 38 8 54 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_88501_419_839_- FIG00000159 99 15 99 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_88505_8_331_- FIG00000871 4 2 6 Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) Histidine Biosynthesis 1 T2D_unique_88513_1_839_- FIG01304636 28 9 30 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_88535_1_170_+ FIG00475203 46 6 46 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_88535_201_838_+ FIG00003086 178 26 178 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_88545_1_838_- FIG00013626 24 8 27 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_88553_268_576_+ FIG00002344 19 3 20 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_88595_1_255_+ FIG00002914 23 7 43 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_88600_1_449_- FIG00000396 27 8 28 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_88618_575_838_+ FIG00004169 8 3 10 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_88666_1_838_- FIG00000401 144 24 152 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_88676_1_449_- FIG00026137 36 10 37 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_88682_1_662_+ FIG00000377 27 9 28 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_88695_1_553_- FIG00001237 158 22 158 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_88737_481_837_+ FIG00000243 8 3 12 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_88747_158_823_+ FIG00026918 134 22 135 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_88748_281_682_+ FIG00046929 105 15 106 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_88753_1_405_+ FIG00000539 89 15 91 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_88815_1_365_- FIG00005727 5 3 6 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_88827_497_837_+ FIG00051439 6 2 8 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_88873_1_228_+ FIG00002110 58 9 58 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_88875_1_244_+ FIG00000276 65 10 65 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_unique_88875_256_591_+ FIG00007256 82 13 82 FIG139598: Potential ribosomal protein CBSS-176279.3.peg.868 1.x T2D_unique_88899_1_836_+ FIG00000025 203 31 203 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_88925_1_836_- FIG00080231 217 33 218 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_88929_1_836_+ FIG00000402 30 9 33 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_88939_194_836_- FIG00000224 49 11 51 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_88945_1_836_- FIG00138741 127 25 128 Aldehyde dehydrogenase B (EC 1.2.1.22) Methylglyoxal Metabolism 3.x T2D_unique_89004_1_796_- FIG00138258 210 31 210 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_89014_439_836_+ FIG00000174 106 15 106 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_unique_89018_104_571_+ FIG00000325 10 4 12 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_89018_594_836_+ FIG00000168 13 4 14 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_89043_218_805_- FIG00007495 7 3 8 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_89048_42_835_- FIG00000404 56 14 58 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_89085_423_835_+ FIG00024401 5 2 6 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_89126_1_262_+ FIG00067248 24 7 26 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_89142_1_403_+ FIG00108342 9 4 11 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_89160_1_835_+ FIG00088067 60 15 63 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_89209_324_835_- FIG00011382 7 4 11 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_unique_89223_1_835_+ FIG00034851 242 34 242 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_89265_1_834_- FIG00000343 137 24 138 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_89281_1_500_- FIG00004589 5 4 7 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_89317_1_403_- FIG00001449 16 3 17 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_unique_89362_1_769_- FIG00008507 48 12 49 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_89385_630_834_- FIG00138258 4 2 5 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_89403_1_345_+ FIG00001882 50 11 51 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_89404_664_834_+ FIG00047414 4 2 5 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_89443_478_669_+ FIG01016270 18 4 19 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_89475_1_168_+ FIG00001642 10 3 11 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_89544_270_656_+ FIG00002320 4 3 5 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_unique_89567_504_833_- FIG00000065 61 11 63 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_89571_261_833_+ FIG00004655 48 11 50 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_89592_1_372_+ FIG00000329 49 9 50 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_89606_358_832_+ FIG00000015 70 13 72 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_89614_1_563_- FIG00000391 141 21 141 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_89621_171_832_+ FIG00029916 166 26 166 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_89632_249_728_- FIG00138171 37 7 38 Queuosine biosynthesis QueD, PTPS-I Zinc regulated enzymes 1 T2D_unique_89657_301_832_- FIG00000464 37 6 38 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_89660_291_832_+ FIG00010134 126 21 126 Methionine transporter MetT Methionine Degradation 3 T2D_unique_89668_1_832_+ FIG00136193 52 13 55 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_89669_101_832_- FIG00012945 3 3 5 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_89692_1_587_- FIG00001469 148 22 148 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_89703_1_652_- FIG00001548 155 22 156 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_89707_1_213_- FIG00062547 47 8 47 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_89719_1_293_- FIG00029758 69 11 69 N-carbamoyl-L-amino acid hydrolase (EC 3.5.1.87) Hydantoin metabolism 4 T2D_unique_89760_1_131_- FIG00229257 17 4 18 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_89775_1_521_- FIG00011468 113 17 113 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_89804_1_185_+ FIG00000356 5 2 6 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_89897_1_600_+ FIG00000465 5 2 7 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_89901_1_467_- FIG00007957 127 17 127 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_89901_483_831_- FIG00000539 96 14 96 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_89902_1_267_- FIG00003715 22 5 23 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_89942_132_830_- FIG00052802 21 7 23 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_unique_89946_80_424_+ FIG00092649 13 3 14 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_89946_433_663_+ FIG00004843 28 6 29 Protein YidD Cell Division Subsystem including YidCD 1 T2D_unique_89955_1_830_+ FIG01305035 43 9 46 Xylose ABC transporter, substrate-binding component Xylose utilization 1 T2D_unique_89956_3_830_- FIG00005727 80 13 82 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_89973_331_830_- FIG00001774 107 16 107 Late competence protein ComGA, access of DNA to ComEA Gram Positive Competence 3100 T2D_unique_90019_456_830_- FIG00000157 39 8 41 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_90038_6_554_- FIG00000355 45 12 47 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_90054_571_830_- FIG00046929 12 4 15 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_90080_1_156_- FIG00000241 35 5 35 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_90094_1_210_+ FIG00134342 50 8 50 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_90143_1_348_- FIG00001076 26 6 28 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_90145_1_829_- FIG00007147 217 32 218 Glycosyltransferase LafB, responsible for the formation of Gal-Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_90165_1_180_+ FIG00018369 6 2 8 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_90166_660_829_- FIG00016555 5 2 7 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_90169_639_829_+ FIG00022899 17 4 18 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_90180_74_829_+ FIG00030688 3 4 5 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_90195_1_196_+ FIG00003587 27 5 29 Radical SAM domain heme biosynthesis protein Heme biosynthesis orphans 3 T2D_unique_90215_550_829_+ FIG00003972 60 10 61 FIGfam003972: membrane protein CBSS-269801.1.peg.1715 1 T2D_unique_90216_1_829_+ FIG00000308 80 18 82 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_90220_173_829_- FIG00058830 165 25 165 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_90222_1_829_- FIG00000188 39 8 41 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_90264_1_828_+ FIG00046358 138 24 139 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_90269_1_813_+ FIG00003088 22 9 32 Arsenical pump-driving ATPase (EC 3.6.3.16) Arsenic resistance 1 T2D_unique_90311_1_188_- FIG00000245 8 3 9 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_90316_382_828_- FIG00000717 47 12 50 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_90359_1_828_+ FIG01260980 246 34 246 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_90382_1_828_- FIG00100439 37 10 39 Translation elongation factor 2 Universal GTPases 2 T2D_unique_90399_1_365_+ FIG00945384 14 5 15 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_90399_374_828_+ FIG00455853 10 4 14 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_90446_1_136_+ FIG00745599 6 2 8 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_90485_687_827_+ FIG00000504 17 4 18 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_90486_7_567_- FIG00041038 28 10 49 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_90536_535_827_+ FIG00002470 14 4 15 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_90540_472_741_+ FIG00000392 5 3 7 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_90553_1_589_+ FIG00000348 14 3 19 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_unique_90558_85_827_+ FIG00000659 106 22 108 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_90566_1_606_+ FIG00006955 49 10 57 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_90584_1_173_- FIG01959388 34 6 35 Putative dihydroxyacetone kinase (EC 2.7.1.29), dihydroxyacetone binding subunit Dihydroxyacetone kinases 3 T2D_unique_90597_91_826_+ FIG00079740 46 10 48 Xyloside transporter XynT Xylose utilization 1 T2D_unique_90619_1_826_+ FIG00052730 47 13 49 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_90626_455_826_+ FIG00453259 89 14 90 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_90657_225_826_+ FIG00008907 7 4 9 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_90662_1_183_- FIG00000235 7 3 8 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_90719_1_826_- FIG00012945 9 5 13 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_90721_1_395_+ FIG00093180 114 15 114 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_90729_1_545_- FIG01306479 8 5 9 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_90748_1_317_+ FIG00623809 40 8 41 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_90779_1_257_- FIG00007157 30 5 31 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_90795_1_825_+ FIG00001354 224 33 224 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_unique_90834_499_825_- FIG00000351 12 3 14 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_90852_379_825_- FIG00001960 4 2 5 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_90879_1_521_- FIG01260980 21 8 23 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_90880_364_717_+ FIG00000402 4 2 6 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_90910_1_825_- FIG00042616 69 13 71 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_90968_1_824_+ FIG00000412 147 24 148 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_90982_646_824_+ FIG00000838 6 3 7 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_91001_351_569_+ FIG00002328 10 4 12 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_91010_520_824_- FIG00023369 17 4 19 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_91018_1_446_+ FIG00000532 115 17 115 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_91028_1_824_+ FIG00046358 9 5 11 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_91069_120_398_- FIG00000377 71 10 71 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_91086_355_824_+ FIG00021484 3 2 5 Metallo-beta-lactamase superfamily domain protein in prophage Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_91089_1_824_+ FIG00085033 9 4 13 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_91095_1_734_+ FIG00000402 22 7 24 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_91121_1_806_- FIG01260980 218 32 218 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_91182_1_823_- FIG00023943 28 7 30 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_91198_1_533_- FIG00002470 13 5 14 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_91223_1_823_- FIG01260980 28 8 40 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_91229_1_564_- FIG00000985 28 6 30 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_91235_1_823_+ FIG00002011 213 32 214 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_unique_91257_340_823_- FIG00030174 31 8 33 Predicted arginine uptake transporter Arginine Biosynthesis extended 1.0 T2D_unique_91267_606_823_+ FIG00000434 19 5 20 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_91275_1_517_+ FIG00000721 48 10 49 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_91277_1_623_+ FIG00009450 168 25 168 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_91289_38_822_- FIG00001036 5 3 8 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_91349_1_126_- FIG00134889 9 2 11 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_91349_144_281_- FIG00145509 3 2 4 Glutamate synthase, alpha subunit domain protein Ammonia assimilation 1 T2D_unique_91351_1_822_+ FIG00028461 66 14 67 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_91367_44_505_- FIG00005647 117 18 117 Chemotaxis protein CheD Bacterial Chemotaxis 9 T2D_unique_91367_513_822_- FIG00002947 75 12 75 Chemotaxis protein CheC -- inhibitor of MCP methylation Bacterial Chemotaxis 9 T2D_unique_91405_1_822_+ FIG00046358 41 12 43 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_91416_1_748_+ FIG00016663 177 27 178 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_91428_1_126_+ FIG00001406 32 5 32 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_91444_436_822_- FIG00013339 11 4 12 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_91451_394_822_+ FIG00003129 105 16 105 Galactose operon repressor, GalR-LacI family of transcriptional regulators Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_91476_143_821_- FIG00904859 5 3 7 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_unique_91477_1_821_- FIG00719736 204 31 204 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_91498_65_821_- FIG00133515 190 28 191 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_91528_1_821_- FIG00019652 37 9 39 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_91608_1_259_- FIG00899307 37 6 38 Monofunctional biosynthetic peptidoglycan transglycosylase (EC 2.4.2.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_91625_259_821_- FIG00000979 144 20 144 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_unique_91646_1_661_- FIG00000358 169 26 169 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_91680_28_820_+ FIG00005172 161 27 162 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_91718_1_372_+ FIG00005204 44 7 45 Inner membrane component of tripartite multidrug resistance system Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 1 T2D_unique_91747_1_820_- FIG00000476 18 8 21 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_91756_1_743_+ FIG00038726 166 26 167 Ferric siderophore transport system, periplasmic binding protein TonB Hemin transport system 1 T2D_unique_91771_1_504_+ FIG01290653 59 14 60 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_91776_1_820_- FIG00001548 28 7 30 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_91792_1_630_- FIG00000494 12 4 14 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_91811_432_820_+ FIG00005216 32 7 35 Sulfate permease Cysteine Biosynthesis 2.17 T2D_unique_91912_1_486_+ FIG01114754 102 17 111 CRISPR-associated protein, Csn2 family CRISPRs 1 T2D_unique_91943_429_819_+ FIG00001264 12 2 14 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_91971_481_819_+ FIG00049915 17 3 18 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_91982_1_819_- FIG00136692 119 22 120 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_91999_1_202_+ FIG00011659 40 6 41 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_92071_681_818_+ FIG00000448 20 3 20 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_92092_407_818_+ FIG00000680 83 14 86 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_92115_152_739_- FIG00001642 22 5 23 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_92148_483_707_+ FIG00147164 7 3 8 Fe-containing alcohol dehydrogenase Inositol catabolism 5.x T2D_unique_92178_1_684_+ FIG00001189 16 5 26 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_92186_1_368_- FIG01307086 4 3 10 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_92189_380_817_+ FIG00000368 14 5 16 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_92197_431_817_- FIG00008572 23 6 24 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_92213_1_772_+ FIG00000863 9 6 12 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_92219_1_254_- FIG00001306 58 9 58 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_unique_92229_1_817_- FIG00000176 74 18 77 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_92235_1_278_+ FIG00000001 57 10 57 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_92264_1_817_- FIG00016566 142 26 143 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_92266_1_817_+ FIG00041382 3 3 5 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_92270_605_817_- FIG00000296 5 2 7 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_unique_92280_1_460_- FIG00001401 116 18 116 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_92307_65_817_- FIG00139058 5 3 12 Putrescine/proton symporter, putrescine/ornithine antiporter PotE Polyamine Metabolism 2 T2D_unique_92315_1_817_- FIG00000032 4 3 7 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_92323_1_817_- FIG00003251 5 5 18 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_92343_1_355_- FIG01260980 51 8 52 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_92358_360_817_+ FIG00060517 9 3 10 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_92362_1_486_+ FIG00006887 46 9 48 ABC transporter, predicted N-acetylneuraminate-binding protein Sialic Acid Metabolism 1.x T2D_unique_92376_1_448_- FIG00018699 91 15 92 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_92414_1_750_+ FIG00000793 34 10 38 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_92422_1_271_+ FIG00031250 61 9 61 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_92438_1_592_+ FIG00001547 6 4 8 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_92464_413_816_+ FIG00719736 3 3 5 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_92476_1_816_- FIG00004078 8 3 9 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_92517_1_264_+ FIG00000001 7 5 31 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_92527_1_559_- FIG00019868 3 5 5 Maltose/maltodextrin ABC transporter, permease protein MalF Maltose and Maltodextrin Utilization 1.x T2D_unique_92535_1_816_+ FIG00000085 221 32 221 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_92554_1_223_- FIG00008556 6 3 7 L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_92570_310_815_- FIG00046358 27 8 34 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_92573_1_815_+ FIG00018457 88 16 96 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_92585_1_128_- FIG00229360 3 2 4 Tagatose-6-phosphate kinase (EC 2.7.1.144) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_92627_1_684_+ FIG00000420 48 15 50 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_92678_1_204_- FIG00001469 53 7 53 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_92717_1_257_+ FIG00084105 14 4 15 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_92764_1_248_- FIG00000177 33 6 34 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_92783_292_814_- FIG00000145 10 2 12 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_92787_580_814_+ FIG00000089 8 2 9 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_92789_1_392_- FIG00002020 50 9 51 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_92794_1_814_- FIG00023943 192 28 193 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_92806_1_678_+ FIG00009149 82 20 88 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_92839_456_814_+ FIG00002914 43 8 43 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_92850_506_814_+ FIG00001675 61 12 61 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_92887_386_814_+ FIG00000422 3 3 4 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_92892_540_758_+ FIG00521220 13 3 15 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_92976_1_813_- FIG00003174 25 7 28 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_92981_1_813_+ FIG00138258 79 16 81 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_92989_206_813_+ FIG00000038 94 19 96 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_93004_213_434_- FIG00139706 11 2 13 N-acetyl glucosamine transporter, NagP Chitin and N-acetylglucosamine utilization 2 T2D_unique_93018_1_813_+ FIG00000414 52 12 55 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_93041_1_813_+ FIG00018369 160 29 161 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_93105_1_191_+ FIG00011057 11 2 12 Deoxyribonucleoside regulator DeoR (transcriptional repressor) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_93111_355_812_+ FIG00018369 66 12 67 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_93148_140_812_+ FIG00000113 113 23 114 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_93159_1_290_+ FIG00000111 20 5 22 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_93173_1_175_+ FIG00135554 18 4 19 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_93175_59_812_+ FIG00048014 85 15 88 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_93182_258_683_- FIG00059124 116 16 116 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_93279_1_705_+ FIG00006151 11 3 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_93301_1_510_+ FIG00846773 113 17 113 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_93342_8_811_- FIG00093180 14 4 16 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_93348_1_743_+ FIG00039969 14 4 16 CRISPR-associated protein, Csm5 family CRISPR-associated cluster 1 T2D_unique_93381_136_420_- FIG00000388 8 3 9 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_93396_44_811_- FIG00715305 79 17 81 Formyl-coenzyme A transferase (EC 2.8.3.16) Glycolate, glyoxylate interconversions ? T2D_unique_93402_626_811_- FIG00010844 13 4 15 Flavodoxin Flavodoxin 1 T2D_unique_93435_1_393_- FIG00011423 5 2 7 Ferredoxin reductase Anaerobic respiratory reductases 3 T2D_unique_93437_1_369_+ FIG00000532 45 8 46 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_93462_84_811_+ FIG00000163 20 8 22 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_93465_251_811_+ FIG00007157 14 3 15 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_93472_194_811_+ FIG00047056 149 23 150 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_93500_395_810_+ FIG00135554 30 8 31 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_93539_1_381_+ FIG00000777 4 3 10 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_93542_1_326_- FIG00067681 56 11 57 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_93542_443_810_- FIG00000151 51 9 53 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_93580_615_810_- FIG00000503 15 2 15 Cobalt-zinc-cadmium resistance protein CzcD Cobalt-zinc-cadmium resistance 1.26 T2D_unique_93585_1_549_- FIG00136866 44 10 46 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_93627_346_810_- FIG00000584 31 10 32 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_93645_1_809_- FIG00719736 23 7 25 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_93647_1_693_+ FIG00016566 97 18 98 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_93663_1_525_+ FIG00132617 9 9 51 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_93669_275_763_- FIG00000333 23 5 31 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_93696_610_809_- FIG00000936 46 7 46 Pantothenate kinase (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_93705_538_809_+ FIG00001819 33 7 34 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_93735_1_809_- FIG00000350 23 8 24 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_93745_1_809_- FIG00040817 35 13 38 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_93747_1_809_+ FIG00001653 158 26 160 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_93854_540_808_+ FIG00011987 10 3 11 Stage III sporulation protein AD Sporulation Cluster III A 1.x T2D_unique_93866_1_252_+ FIG00554193 19 5 21 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_93869_1_808_- FIG00000268 107 20 108 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_93878_1_612_- FIG00023143 83 15 84 Autolysis response regulater LytR Murein hydrolase regulation and cell death 1.2 T2D_unique_93930_485_808_+ FIG00077620 49 9 50 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_93936_1_244_+ FIG00001133 21 6 22 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_unique_93974_291_797_+ FIG00000897 5 3 6 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_94042_1_643_+ FIG00027222 39 12 44 GDP-L-fucose synthetase (EC 1.1.1.271) Capsular heptose biosynthesis 1 T2D_unique_94080_1_642_+ FIG00000157 102 19 103 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_94086_1_520_- FIG00061313 12 5 15 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_94135_1_807_+ FIG01304601 109 20 111 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_94149_1_214_+ FIG00129616 21 4 22 GTP-binding protein EngA Universal GTPases 2 T2D_unique_94149_217_807_+ FIG00000459 17 5 19 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_94153_101_807_- FIG00719736 43 14 45 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_94167_274_753_- FIG00000720 27 8 28 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_94180_1_807_- FIG00001548 10 5 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_94189_1_360_- FIG00005131 107 14 107 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F1 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_94203_1_594_- FIG00093180 20 7 22 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_94260_361_806_+ FIG00000314 24 7 25 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_94280_154_687_- FIG00103661 137 21 137 Transcriptional regulator, MerR family, near polyamine transporter Polyamine Metabolism 2 T2D_unique_94313_1_673_- FIG00006868 26 7 27 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_94327_146_806_+ FIG01560076 22 5 23 Glycosyl transferase, group 1 CBSS-258594.1.peg.3339 1 T2D_unique_94328_1_806_+ FIG00001882 236 32 236 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_94375_1_211_- FIG00080955 14 3 15 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_94393_1_806_+ FIG01010650 137 24 138 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_94402_1_806_- FIG00000011 192 29 193 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_94403_1_805_+ FIG00000402 64 17 67 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_94420_1_805_- FIG00000672 83 17 85 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_94437_1_522_+ FIG01322883 29 8 30 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_94466_1_805_+ FIG00016514 30 8 32 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_94524_1_276_+ FIG00000967 38 7 39 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_unique_94526_330_805_+ FIG00000402 8 2 10 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_94531_1_617_- FIG00000025 5 3 7 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_94533_93_805_+ FIG00018536 12 7 17 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_94556_1_804_- FIG00001548 71 18 73 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_94578_633_804_- FIG00598409 9 3 11 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_94606_35_550_+ FIG00000892 124 18 125 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_94617_70_804_+ FIG00000132 195 28 196 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_94622_1_211_- FIG00000385 14 4 15 Cell division protein FtsA Cell Division Cluster 1.x T2D_unique_94625_1_609_- FIG00000721 63 15 65 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_94658_123_428_+ FIG00057987 9 3 11 Pyruvate:ferredoxin oxidoreductase, delta subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_94702_1_804_- FIG00136692 81 17 92 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_94703_1_804_- FIG00001337 193 32 193 Na(+)-translocating NADH-quinone reductase subunit A (EC 1.6.5.-) Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_94710_1_804_+ FIG00018699 197 31 197 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_94761_1_804_- FIG00023943 203 30 204 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_94777_1_451_- FIG00000372 101 16 101 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_94778_552_803_- FIG00000088 34 7 35 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_94785_593_803_+ FIG00000317 49 8 49 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_94831_1_496_+ FIG00013638 44 12 45 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_94831_502_803_+ FIG00013638 19 4 20 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_94834_1_279_- FIG00000477 12 3 13 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_94857_500_803_+ FIG00013339 31 6 32 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_94875_1_218_- FIG00138468 14 4 16 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_94875_443_803_+ FIG01260980 35 8 37 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_94880_1_803_- FIG00000578 43 10 45 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_94912_284_803_- FIG00451095 100 15 101 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_94958_1_352_+ FIG00001498 79 12 79 Chorismate mutase I (EC 5.4.99.5) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_94987_532_802_- FIG00126843 13 4 14 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_95009_499_802_+ FIG00001712 17 4 18 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_95015_1_571_- FIG00016768 11 3 12 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_95016_81_802_- FIG00010262 97 20 98 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) EC699-706 1 T2D_unique_95041_1_380_+ FIG00000210 37 9 38 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_95096_1_802_+ FIG00561498 212 31 213 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_95112_581_802_- FIG00013366 6 2 7 ADP-heptose--lipooligosaccharide heptosyltransferase II (EC 2.4.1.-) LOS core oligosaccharide biosynthesis 1.x T2D_unique_95132_92_322_+ FIG00010262 23 6 24 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) EC699-706 1 T2D_unique_95140_22_801_- FIG00004078 60 12 61 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_95168_1_148_+ FIG00000835 17 4 17 NAD-dependent malic enzyme (EC 1.1.1.38) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_95171_508_801_- FIG00003507 71 11 71 6-phospho-beta-galactosidase (EC 3.2.1.85) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_95217_558_801_- FIG00000367 24 5 25 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_95233_1_379_- FIG00000494 9 2 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_95233_414_801_- FIG00007586 4 3 7 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_95320_1_432_+ FIG00031250 7 4 9 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_95334_298_800_+ FIG00006151 20 7 22 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_95347_1_722_- FIG00000343 15 14 73 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_95359_1_800_- FIG00139050 30 7 32 Anaerobic glycerol-3-phosphate dehydrogenase subunit C (EC 1.1.5.3) Respiratory dehydrogenases 1 1.129 T2D_unique_95360_334_771_+ FIG00026918 106 16 107 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_95398_1_274_- FIG00000721 7 4 10 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_95409_48_761_- FIG00002130 17 6 18 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_95447_564_800_+ FIG00000594 13 4 14 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_95455_1_651_+ FIG00023943 189 26 189 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_95484_1_403_- FIG00138468 23 5 24 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_95500_1_800_+ FIG00000456 74 18 75 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_95502_30_458_- FIG00132839 7 2 9 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_95504_517_800_+ FIG00041382 4 2 7 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_95514_1_799_- FIG00002416 75 15 78 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_95518_1_743_+ FIG00004037 184 27 184 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_95520_1_158_- FIG00000036 20 5 21 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_95524_1_227_- FIG00000043 37 6 38 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_95538_1_346_- FIG00340853 18 3 20 Oxalyl-CoA decarboxylase (EC 4.1.1.8) Glycolate, glyoxylate interconversions ? T2D_unique_95543_1_268_- FIG00052300 36 7 36 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_95579_1_799_+ FIG00078083 185 30 187 5'-nucleotidase family protein in cluster with NagD-like phosphatase Purine conversions 4.1118100 T2D_unique_95603_1_528_+ FIG00005112 123 20 123 Trehalose synthase (EC 5.4.99.16) Trehalose Biosynthesis 1.2 T2D_unique_95604_457_799_+ FIG00007025 6 3 8 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_95614_1_312_- FIG00018396 14 4 15 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_95619_1_318_+ FIG00000621 16 5 18 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_95627_217_651_- FIG00025216 108 16 109 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_95653_604_799_+ FIG00060517 51 7 51 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_95687_1_798_+ FIG00041038 35 13 39 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_95720_1_158_- FIG00031250 27 5 31 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_95720_335_798_+ FIG00000911 25 7 26 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_95722_227_798_+ FIG00010454 46 11 49 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_95750_1_798_- FIG00001548 78 17 105 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_95783_436_798_- FIG00000860 86 14 86 O-succinylbenzoic acid--CoA ligase (EC 6.2.1.26) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_95809_576_740_+ FIG00000990 31 5 32 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_95822_126_798_- FIG00000474 170 25 170 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_95846_491_798_- FIG01955782 4 2 5 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_95877_1_399_- FIG00000397 12 5 14 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_95922_1_255_+ FIG00010738 9 3 11 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_95927_1_797_- FIG00061313 15 4 17 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_95937_1_797_+ FIG01260980 26 10 29 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_95966_1_656_- FIG00140689 23 5 25 low-specificity D-threonine aldolase Serine-glyoxylate cycle 1 T2D_unique_95993_1_386_+ FIG00017458 22 7 25 Sensor histidine kinase VncS Streptococcus pneumoniae Vancomycin Tolerance Locus 3 T2D_unique_95998_1_797_+ FIG00006699 38 12 41 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_unique_96020_250_797_- FIG00005547 45 11 47 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_unique_96021_1_797_+ FIG00038343 14 5 16 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_96022_1_399_- FIG00147862 19 5 21 DNA sulfur modification protein DndB DNA phosphorothioation 1 T2D_unique_96028_1_797_+ FIG00041038 14 2 14 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_96077_1_302_- FIG00023943 79 11 79 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_96087_209_796_- FIG00000117 84 15 86 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_96099_242_586_- FIG00001616 51 10 53 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_96114_1_611_+ FIG00030191 153 23 153 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_96114_627_796_+ FIG00000464 44 6 44 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_96176_1_503_- FIG00000402 130 20 130 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_96180_1_152_+ FIG00049433 9 3 10 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_96210_1_796_- FIG00024930 121 21 122 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_96221_298_796_+ FIG00001094 82 14 83 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_96225_1_423_+ FIG00077620 6 3 8 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_96229_1_796_- FIG00003788 46 12 48 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_96287_1_532_- FIG00021289 10 5 12 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_96318_205_795_- FIG00002049 52 13 54 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_96338_1_168_+ FIG00000388 43 6 43 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_96374_1_548_+ FIG00000821 16 4 26 Adenylylsulfate kinase (EC 2.7.1.25) Cysteine Biosynthesis 2.17 T2D_unique_96452_299_795_- FIG00003212 8 5 10 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_96483_1_794_- 6 2 8 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_96497_1_679_- FIG00007514 77 17 78 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_96509_1_794_+ FIG00002614 5 5 10 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_96551_1_588_+ FIG00000402 40 10 41 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_96554_1_794_- FIG00000575 56 13 58 L-aspartate oxidase (EC 1.4.3.16) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_96555_403_794_- FIG00001106 40 8 41 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_96564_539_794_+ FIG00000184 63 9 63 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_96572_1_716_+ FIG00000672 58 14 62 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_96609_1_328_+ FIG01955850 77 12 80 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_96609_334_794_+ FIG00006734 5 4 8 4-amino-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) acetyltrasferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_96610_416_794_+ FIG00002460 14 5 18 V-type ATP synthase subunit D (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_96623_1_385_+ FIG00000163 87 13 88 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_96630_185_794_+ FIG00000434 64 15 65 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_96635_1_794_+ FIG00066643 40 8 45 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_96676_217_794_+ FIG00000011 131 20 131 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_96679_617_794_+ FIG00005992 30 6 30 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_96692_435_793_+ FIG00047509 10 3 11 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_96699_417_793_+ FIG00000088 84 13 85 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_96709_1_793_- FIG00044622 126 20 127 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_96728_1_386_- FIG00719736 10 6 11 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_96734_313_793_+ FIG00000085 23 4 24 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_96748_280_793_+ FIG00000812 113 19 113 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_96753_152_793_- FIG00001406 153 24 154 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_96769_410_793_+ FIG00001583 6 5 7 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_96770_1_627_+ FIG00000863 16 5 20 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_96813_1_415_+ FIG00009210 61 9 63 FIG009210: peptidase, M16 family CBSS-257314.1.peg.676 4.x T2D_unique_96814_431_793_+ FIG00000474 52 8 53 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_96815_545_793_- FIG00074225 51 8 53 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_96818_1_432_+ FIG00000532 37 8 39 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_96832_409_783_+ FIG00133515 95 14 96 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_96837_423_793_- FIG01312219 18 3 19 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_unique_96848_1_793_- FIG00132617 192 30 192 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_96866_1_793_+ FIG00000642 93 19 132 Spermidine synthase (EC 2.5.1.16) Polyamine Metabolism 2 T2D_unique_96874_1_398_- FIG00000520 25 5 27 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_96879_1_630_+ FIG00031250 146 23 146 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_96893_1_792_- FIG00000380 20 4 21 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_96904_495_792_+ FIG00000085 77 11 77 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_96928_1_792_+ FIG00000425 191 30 191 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_96948_1_792_+ FIG00061313 93 24 94 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_97043_597_792_- FIG00000212 46 7 46 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_97054_239_792_+ FIG00001469 11 5 12 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_97057_1_792_- FIG01260980 233 32 233 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_97060_256_792_- FIG00000139 28 6 31 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_97068_1_570_- FIG00000402 106 19 108 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_97072_261_641_- FIG00006868 31 8 32 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_97076_1_792_- FIG00002864 19 5 22 [Protein-PII] uridylyltransferase (EC 2.7.7.59) CBSS-312309.3.peg.1965 1 T2D_unique_97118_1_791_+ FIG00000025 219 31 219 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_97124_1_791_- FIG00010508 75 19 77 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_97179_240_791_+ FIG00019251 10 6 25 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_97197_1_362_- FIG00000163 40 10 42 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_97210_1_465_+ FIG00000926 131 19 131 Predicted L-lactate dehydrogenase, Fe-S oxidoreductase subunit YkgE Lactate utilization 3 T2D_unique_97225_1_791_- FIG00001732 17 8 23 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_97268_1_188_- FIG00000422 7 4 9 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_97312_1_790_- FIG00041038 219 31 219 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_97330_1_207_- FIG00000040 33 5 33 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_97340_1_552_+ FIG00000185 47 10 48 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_97344_1_505_- FIG00000476 7 3 8 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_97349_1_360_- FIG00515041 4 2 6 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Alkanesulfonate assimilation 9.? T2D_unique_97359_183_790_+ FIG00010194 4 4 7 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_97361_576_790_+ FIG00016110 13 5 14 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_97366_1_632_+ FIG00006151 183 25 183 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_97367_1_790_+ FIG00076542 41 12 43 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_97391_1_790_+ FIG00001518 8 7 15 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_97405_131_790_+ FIG00138820 43 8 46 5-aminopentanamidase (EC 3.5.1.30) Lysine degradation 1.0 T2D_unique_97462_1_790_+ FIG00134889 142 23 143 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_97480_482_790_+ FIG00000422 11 5 12 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_97517_561_789_- FIG00004453 9 2 10 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_97553_52_351_- FIG00052730 19 5 20 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_97554_265_789_+ FIG00000446 22 6 23 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_97575_158_789_+ FIG00029916 139 23 145 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_97598_1_411_+ FIG00000116 12 2 14 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_97605_1_155_- FIG00029916 40 6 40 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_97613_1_533_+ FIG00000304 28 8 30 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_97615_1_349_- FIG00132787 91 13 91 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_97616_1_789_- FIG00000402 184 29 185 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_97631_1_669_+ FIG00000301 177 25 177 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_97634_1_789_- FIG00094401 59 17 123 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_97636_258_789_+ FIG00000482 62 15 63 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_97668_1_789_+ FIG00031250 16 7 19 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_97686_588_789_+ FIG00000282 8 3 9 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_97699_1_789_+ FIG00002541 172 27 173 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_97703_1_789_+ FIG00000578 156 24 157 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_97732_134_532_- FIG00001354 70 12 71 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_unique_97741_361_788_- FIG00004502 14 4 15 5'-nucleotidase YjjG (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_97764_1_220_- FIG00000121 48 8 49 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_97834_1_788_- FIG00016514 97 18 109 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_97894_1_788_+ FIG00093180 210 32 212 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_97895_121_788_- FIG00050243 142 24 143 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_97914_1_596_+ FIG00009889 139 22 139 Mevalonate kinase (EC 2.7.1.36) Isoprenoid Biosynthesis 2.x T2D_unique_97963_1_787_+ FIG00000268 142 26 144 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_98012_521_787_- FIG00000287 59 10 62 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_98020_516_787_- FIG00001088 72 10 72 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_98029_529_732_+ FIG00000126 11 5 12 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_98044_1_787_- FIG00001168 50 14 82 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_98075_475_787_+ FIG01304636 16 4 17 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_98082_1_787_+ FIG00000962 80 17 82 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_98092_28_787_+ FIG00031969 54 13 57 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_98093_71_667_- FIG00000392 149 22 150 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_98112_1_787_- FIG00000085 211 31 211 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_98134_1_220_+ FIG01318274 6 2 8 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_98138_1_786_- FIG00025086 17 8 19 Xanthine permease Purine Utilization 1 T2D_unique_98150_1_786_- FIG00133628 25 5 27 Nitric oxide reductase activation protein NorD Flavohaemoglobin 1 T2D_unique_98165_1_126_+ FIG00000282 12 3 13 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_98249_260_786_+ FIG00132994 14 3 16 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_98289_463_786_+ FIG00451095 3 3 4 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_98299_346_786_+ FIG00002716 3 2 4 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_98325_1_507_- FIG00000212 44 9 45 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_98337_497_785_+ FIG00001134 78 11 78 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_unique_98344_1_756_+ FIG00005243 83 19 86 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_98383_1_373_- FIG00000382 43 9 44 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_98411_657_785_- FIG00000194 11 3 13 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_98442_1_785_- FIG00067681 56 11 58 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_98460_22_744_+ FIG00000202 32 10 34 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_98462_238_785_- FIG00122145 7 4 9 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_98470_62_785_+ FIG00000539 196 28 196 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_98473_323_785_+ FIG00007514 10 5 12 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_98495_1_395_- FIG00003555 38 7 39 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_98539_276_784_+ FIG00000075 139 20 139 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_98590_225_784_+ FIG00083946 60 13 62 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_98612_1_356_+ FIG00000474 16 3 17 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_98628_1_338_+ FIG00000985 7 3 9 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_98628_362_784_+ FIG00018396 11 4 13 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_98633_1_577_+ FIG00000578 42 10 43 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_98650_357_784_+ FIG00000025 24 5 26 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_98651_1_284_- FIG00008907 45 7 46 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_98685_1_579_+ FIG00004655 30 8 31 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_98692_599_784_+ FIG00000402 10 3 11 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_98706_480_784_+ FIG00008342 82 12 82 Anaerobic sulfite reductase subunit A Anaerobic respiratory reductases 3 T2D_unique_98733_416_727_+ FIG01318274 13 4 14 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_98738_1_317_+ FIG00024851 74 11 74 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_98822_1_783_- FIG00034293 79 17 81 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_98830_1_662_+ FIG00001676 10 5 12 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_98831_1_783_- FIG01260980 16 8 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_98845_1_783_- FIG00000015 29 8 31 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_98856_444_783_+ FIG00000494 28 7 30 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_98859_1_783_- FIG00452446 203 31 204 COG0028: Thiamine pyrophosphate-requiring enzymes Acetoin, butanediol metabolism 5 T2D_unique_98881_1_514_- FIG00007495 99 17 100 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_98895_1_665_- FIG00021289 42 11 44 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_98901_1_289_- FIG00001528 16 5 18 Cobalt-precorrin-3b C17-methyltransferase Cobalamin synthesis 2 T2D_unique_98901_305_783_- FIG00014596 13 4 15 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_98913_1_436_- FIG00000793 3 3 6 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_98959_215_598_+ FIG00012841 59 11 59 Possible alternative L-fucose mutarotase L-fucose utilization 1 T2D_unique_98991_499_782_- FIG00034973 65 10 65 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_unique_98998_1_782_+ FIG00018699 63 15 65 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_99000_1_782_- FIG00002020 229 32 229 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_99008_1_283_+ FIG00122145 9 3 10 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_99011_1_505_- FIG00000242 11 2 13 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_99011_520_782_- FIG00521220 10 3 11 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_99012_65_782_- FIG00004037 35 9 38 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_99041_1_197_- FIG00022899 10 3 11 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_99055_521_782_+ FIG00000268 3 2 4 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_99081_574_782_- FIG00004078 6 3 8 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_99088_1_782_- FIG00000985 212 30 213 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_99142_380_637_+ FIG01954533 9 4 11 Phosphocarrier protein of PTS system Fructose utilization 1 T2D_unique_99196_1_781_- FIG00011537 220 31 220 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_99200_131_781_+ FIG00121768 11 6 13 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_99207_67_405_- FIG00002803 17 5 18 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_99207_407_781_- FIG00000401 33 10 34 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_99249_314_781_- FIG00451095 37 10 44 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_99251_1_781_- FIG00130344 88 18 92 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_99256_1_221_+ FIG00000840 30 6 32 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_99262_1_252_+ FIG00000015 9 4 11 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_99269_1_781_- FIG00016187 209 31 209 Arginine utilization protein RocB Arginine and Ornithine Degradation 1.34 T2D_unique_99287_1_281_- FIG00000076 51 9 52 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_99287_353_781_- FIG00058830 109 17 109 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_99292_596_781_- FIG00031250 20 4 21 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_99326_1_781_- FIG00001269 40 10 41 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_99347_1_778_+ FIG00000151 73 14 74 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_99358_469_781_- FIG00021289 17 3 19 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_99371_433_780_- FIG00000391 57 10 64 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_99377_565_780_- FIG00019652 45 7 45 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_99425_1_470_+ FIG00001469 121 18 121 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_99471_1_780_+ FIG00000927 33 8 35 Methylmalonyl-CoA mutase (EC 5.4.99.2) Serine-glyoxylate cycle 1 T2D_unique_99476_1_718_+ FIG00018369 75 14 77 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_99490_110_445_+ FIG00000219 14 5 16 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_99525_456_780_+ FIG00077188 6 3 7 Substrate-specific component TrpP of tryptophan ECF transporter ECF class transporters 345678 T2D_unique_99574_334_779_+ FIG00001065 3 3 5 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_99580_580_779_+ FIG00020613 30 4 31 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_99599_1_332_+ FIG00029916 77 12 77 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_99599_347_763_+ FIG00121768 114 16 114 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_99604_541_779_- FIG00002328 17 4 18 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_99607_1_608_- FIG00000303 159 23 159 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_99609_246_779_- FIG00002414 101 18 102 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_unique_99611_1_200_+ FIG00051439 4 2 5 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_99622_108_779_- FIG00000165 92 17 93 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_99718_1_779_- FIG00008490 62 10 64 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_99727_256_779_+ FIG00598409 145 21 145 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_99748_86_779_+ FIG00047056 28 7 29 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_99784_55_588_+ FIG00001253 29 6 31 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_99800_1_778_- FIG00010876 210 29 210 Two-component sensor kinase YesM (EC 2.7.3.-) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_99880_406_778_- FIG00000402 5 3 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_99881_1_778_- FIG01955818 97 16 99 Pyruvate:ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_99917_1_268_+ FIG00000538 32 7 33 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_unique_100018_282_777_+ FIG00001550 20 6 22 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_100019_1_243_- FIG00001237 25 4 26 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_100024_567_777_+ FIG00038456 41 7 41 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_100036_1_777_+ FIG00007957 82 18 84 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_100045_1_345_- FIG00006955 10 4 12 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_100059_1_692_+ FIG00016566 68 14 69 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_100063_1_540_- FIG00041038 66 15 67 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_100066_1_623_- FIG00000812 27 7 30 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_100070_637_777_+ FIG00134060 3 2 4 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_100102_387_777_+ FIG00066425 40 9 41 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_100183_175_549_- FIG00000070 87 13 88 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_100185_1_564_- FIG00003555 24 9 26 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_100186_1_776_- FIG00000680 20 7 24 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_100195_462_776_- FIG00002470 6 2 7 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_100248_51_776_- FIG00007079 30 9 32 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_100256_1_703_+ FIG00059211 7 5 9 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_100258_266_514_- FIG00016110 17 4 18 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_100288_1_776_+ FIG00001882 15 5 34 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_100291_1_629_+ FIG00140555 133 22 134 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_100321_1_425_- FIG00006463 106 17 106 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_100342_1_684_- FIG00000043 129 22 130 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_100355_613_776_- FIG00000445 39 6 39 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_100358_1_268_- FIG00051439 16 6 17 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_100381_353_776_- FIG01954013 3 2 4 glycogen debranching enzyme-related protein Glycogen metabolism 3 T2D_unique_100390_1_775_+ FIG00001522 56 12 58 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_100399_1_502_+ FIG00002992 13 5 16 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_100423_324_775_+ FIG00138004 71 12 73 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_100432_1_328_- FIG00126843 40 8 42 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_100440_1_431_- FIG00139192 42 9 43 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_100486_1_315_+ FIG00000301 69 11 71 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_100486_405_775_+ FIG00000333 92 14 92 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_100489_1_775_+ FIG00000343 87 18 88 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_100536_544_775_+ FIG00000287 47 8 47 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_100562_1_523_+ FIG00000434 23 6 26 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_100575_1_195_- FIG00139706 26 4 27 N-acetyl glucosamine transporter, NagP Chitin and N-acetylglucosamine utilization 2 T2D_unique_100588_1_472_- FIG00000208 27 9 29 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_100588_552_774_- FIG00002328 7 3 9 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_100609_154_504_+ FIG00001676 13 4 14 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_100623_1_774_+ FIG00000539 46 13 48 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_100624_146_774_+ FIG00009682 129 22 129 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_100677_1_496_- FIG00000168 49 12 51 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_100684_511_774_- FIG00004655 6 3 7 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_100686_1_774_+ FIG00001753 172 29 173 Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-) Acetoin, butanediol metabolism 5 T2D_unique_100715_1_774_- FIG00022300 111 23 113 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_100718_575_774_+ FIG00075702 40 7 41 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_100720_1_774_- FIG00055715 30 10 33 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_100733_1_370_- FIG00139238 84 14 84 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_100759_397_774_- FIG00022996 75 12 76 Aconitate hydratase (EC 4.2.1.3) Serine-glyoxylate cycle 1 T2D_unique_100765_1_774_+ FIG00000866 187 28 191 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_100768_169_774_- FIG00028476 32 9 34 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_100817_1_773_+ FIG00000476 28 8 30 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_100830_263_773_- FIG00000404 57 14 59 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_100835_1_732_+ FIG00003751 45 12 50 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_100871_181_773_+ FIG00132839 72 15 74 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_100878_1_364_- FIG00023004 104 14 104 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_100933_1_597_+ FIG00002414 20 8 24 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_unique_100937_1_401_+ FIG00003972 8 4 10 FIGfam003972: membrane protein CBSS-269801.1.peg.1715 1 T2D_unique_100956_1_773_- FIG00009682 42 12 44 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_101013_231_772_+ FIG00000522 40 9 42 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_101017_1_137_- FIG00134167 8 3 9 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_101139_1_380_- FIG00000132 33 6 34 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_101216_1_771_- FIG00000055 216 30 216 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_101234_1_482_- FIG00048014 7 6 38 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_101238_1_771_+ FIG01260980 6 4 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_101316_497_771_+ FIG00000185 15 6 16 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_101357_405_771_+ FIG00067248 53 11 55 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_101379_1_194_- FIG00014764 39 6 39 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_101391_521_771_- FIG00000450 7 2 8 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_101394_135_638_+ FIG00134342 22 6 23 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_101410_1_416_- FIG00000208 37 10 38 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_101410_494_727_- FIG00002328 14 5 17 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_101412_1_488_+ FIG00000312 36 7 38 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_101412_603_771_+ FIG00062547 28 5 29 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_101428_184_384_- FIG01270039 14 3 15 Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_unique_101428_397_770_- FIG00138523 76 13 76 Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_unique_101504_564_770_+ FIG00000372 36 6 36 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_101521_1_662_+ FIG00000126 42 11 43 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_101583_229_770_+ FIG00000289 33 13 35 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_101589_1_449_- FIG00001712 41 10 42 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_101589_471_770_- FIG01955818 4 2 5 Pyruvate:ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_101607_1_174_- FIG00006151 9 2 9 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_101620_1_531_- FIG00012945 74 12 77 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_101620_534_770_- FIG00018457 61 9 61 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_101627_1_134_- FIG00000296 27 4 27 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_unique_101631_1_239_- FIG00000842 17 4 17 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_101637_20_769_- FIG00000350 126 23 126 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_101658_1_359_- FIG00088996 18 5 19 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_unique_101672_1_769_+ FIG00041038 96 17 98 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_101678_132_365_+ FIG00000480 13 3 14 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_101681_42_769_- FIG00107349 190 28 190 Glycine/sarcosine/betaine reductase component C chain 1 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_101699_589_769_+ FIG00036983 31 5 31 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_101723_1_769_+ FIG00000425 190 30 191 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_101746_16_480_- FIG00014760 126 18 127 Dimeric dUTPase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_101760_1_769_- FIG00093180 219 31 219 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_101776_1_378_+ FIG00000185 85 13 86 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_101783_45_769_- FIG01304883 4 3 7 Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) Dehydrogenase complexes 1.2100 T2D_unique_101786_1_769_- FIG00060517 201 29 201 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_101832_494_769_- FIG00000352 61 9 61 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_101873_1_363_+ FIG00047414 6 3 7 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_101901_190_768_- FIG00623809 138 21 139 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_101902_1_225_+ FIG00000263 54 8 54 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_101902_276_515_+ FIG00000271 60 9 60 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_unique_101928_1_768_+ FIG00000578 6 5 11 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_101962_1_768_+ FIG00000895 60 13 62 Alanine dehydrogenase (EC 1.4.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_101976_1_768_- FIG00006463 24 6 32 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_101990_1_711_+ FIG00001022 34 8 36 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_101999_1_249_- FIG00000025 39 6 40 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_102037_1_526_+ FIG00028461 36 9 37 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_102060_135_767_+ FIG00000441 70 13 72 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_102070_78_767_- FIG00022899 115 19 115 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_102080_136_767_- FIG00022300 165 25 165 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_102081_1_143_+ FIG00000040 23 4 23 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_102086_1_767_- FIG01292786 118 20 119 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_102093_1_767_+ FIG01960451 177 27 178 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_102099_190_767_+ FIG00041038 163 23 164 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_102109_449_767_+ FIG00000038 24 6 25 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_102138_1_684_+ FIG00008941 38 8 41 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_102141_575_767_+ FIG00000111 11 3 17 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_102151_1_767_+ FIG00025216 158 26 158 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_102152_1_480_+ FIG01304818 7 6 9 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_102161_1_731_+ FIG00025216 8 6 13 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_102170_1_767_+ FIG00049433 20 10 22 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_102182_1_755_- FIG00001667 57 8 58 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_102190_1_510_+ FIG00022899 108 18 109 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_102202_1_597_+ FIG00066425 149 23 150 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_102202_626_767_+ FIG00002958 7 3 8 FIG002958: hypothetical protein Hypothetical Coupled to RecF 1 T2D_unique_102233_1_220_+ FIG00016514 6 3 7 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_102235_1_491_- FIG00133325 108 18 109 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_102236_1_729_- FIG00081563 3 3 6 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_102285_1_579_+ FIG00138182 142 23 142 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_102300_1_260_- FIG00034293 42 8 43 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_102309_1_275_+ FIG00000464 6 4 19 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_102310_1_232_+ FIG00018699 8 3 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_102315_1_223_+ FIG00000315 12 4 13 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_102320_1_766_- FIG00048014 207 30 208 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_102346_465_766_+ FIG00000287 8 2 9 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_102358_232_766_- FIG00028461 20 5 21 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_102367_1_766_+ FIG00001088 5 2 6 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_102373_276_766_- FIG00132666 28 7 29 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_102394_1_766_+ FIG00003174 23 9 26 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_102400_1_587_- FIG00001388 32 10 35 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_unique_102409_1_766_- FIG00451095 34 14 35 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_102472_101_765_+ FIG00132808 12 5 16 Cyclohexadienyl dehydratase (EC 4.2.1.51)(EC 4.2.1.91) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_102481_1_354_+ FIG00000474 82 12 83 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_102481_360_765_+ FIG00074225 107 15 107 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_102493_1_765_+ FIG00000329 121 23 123 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_102519_1_155_+ FIG00000594 9 3 10 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_102525_1_633_+ FIG00005243 39 13 41 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_102536_1_602_+ FIG00018561 135 21 135 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_102548_194_616_+ FIG00126843 9 3 11 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_102550_1_559_- FIG00013626 32 7 49 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_102558_1_431_+ FIG00048507 114 17 114 Catabolite control protein A HPr catabolite repression system 1 T2D_unique_102586_420_765_- FIG00067248 80 13 80 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_102608_1_145_- FIG00002344 26 5 26 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_102631_1_252_- FIG00000304 4 2 5 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_102651_1_458_- FIG00014596 27 6 28 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_102703_1_405_+ FIG00023369 18 6 20 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_102705_405_764_+ FIG00000412 5 2 6 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_102732_1_764_+ FIG00018369 141 27 143 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_102773_1_591_+ FIG00024930 30 8 31 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_102846_1_492_+ FIG00001104 40 11 42 Arginine deiminase (EC 3.5.3.6) Arginine and Ornithine Degradation 1.34 T2D_unique_102873_1_764_+ FIG00001401 221 30 221 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_102887_1_639_+ FIG00000448 14 6 16 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_102890_1_764_+ FIG00745599 66 18 67 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_102892_83_637_- FIG00000645 42 10 44 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_102904_1_546_+ FIG00010738 29 10 30 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_102914_1_388_+ FIG00001436 98 15 98 GlpG protein (membrane protein of glp regulon) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_102928_44_763_- FIG00132666 46 14 49 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_102931_1_763_- FIG00022300 46 11 48 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_102984_1_620_- FIG00067681 85 14 86 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_103157_1_522_- FIG00008490 148 21 148 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_103174_464_762_+ FIG00000017 24 8 25 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_103184_1_372_+ FIG00005547 5 5 7 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_unique_103218_542_762_+ FIG00034293 8 3 9 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_103264_1_691_- FIG00000402 168 27 168 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_103286_1_642_+ FIG01322883 8 3 10 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_103293_1_525_- FIG00001548 19 7 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_103299_492_762_- FIG00059124 25 6 27 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_103306_71_762_+ FIG00002332 14 7 15 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_unique_103352_1_761_+ FIG00000242 187 28 187 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_103362_1_597_- FIG00138004 124 20 125 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_103375_65_415_- FIG00000582 85 13 85 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_103410_1_443_- FIG00045413 35 8 36 Glycerol uptake facilitator protein Dihydroxyacetone kinases 3 T2D_unique_103420_1_761_- FIG00009682 165 28 166 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_103487_1_197_- FIG00000477 34 6 35 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_103506_1_642_+ FIG00000606 60 13 62 Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_103513_1_759_+ FIG00000494 15 4 17 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_103532_442_663_+ FIG00003881 13 3 14 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_103544_1_147_+ FIG00000834 33 5 33 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_103561_1_760_- FIG00002470 181 26 182 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_103608_245_760_- FIG00037240 14 4 16 Alpha-N-arabinofuranosidase 2 (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_103630_1_614_+ FIG00010600 61 12 62 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_103649_1_357_+ FIG00001469 14 5 15 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_103664_567_760_- FIG00025759 4 3 6 Orotate phosphoribosyltransferase (EC 2.4.2.10) De Novo Pyrimidine Synthesis 1 T2D_unique_103667_120_760_- FIG00000672 43 9 45 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_103678_233_760_- FIG00002239 127 19 128 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_103690_1_333_- FIG00008708 7 3 8 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_103702_1_760_+ FIG00134889 134 21 136 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_103737_424_760_+ FIG00001402 4 2 5 Helicase loader DnaI DNA-replication 4 T2D_unique_103752_1_759_+ FIG00000372 35 11 37 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_103777_1_759_+ FIG00000531 57 14 59 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_103795_1_714_- FIG00000130 22 6 25 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_103811_419_759_+ FIG00000279 60 11 61 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_103816_1_759_- FIG00000439 13 9 23 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_103825_1_759_- FIG00028476 28 6 30 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_103867_1_372_- FIG00005698 7 4 9 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_103873_1_386_- FIG00002395 50 7 51 Cysteinyl-tRNA synthetase related protein CBSS-261594.1.peg.788 1 T2D_unique_103877_1_141_+ FIG00009450 5 2 6 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_103878_1_677_+ FIG00002541 14 5 15 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_103901_1_446_+ FIG00000641 12 5 19 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_103939_1_130_+ FIG00002239 29 5 29 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_103940_1_135_- FIG00137509 7 2 8 Alpha-amylase (Neopullulanase) SusA (EC 3.2.1.135) Cellulosome 1.x T2D_unique_103942_585_759_+ FIG00846773 24 5 25 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_103943_1_282_+ FIG00000036 46 9 47 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_103992_1_237_- FIG00000654 9 3 10 tolB protein precursor, periplasmic protein involved in the tonb-independent uptake of group A colicins Ton and Tol transport systems 2 T2D_unique_103994_291_758_+ FIG00011468 25 6 26 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_104007_1_300_+ FIG00001676 57 9 59 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_104037_484_758_+ FIG00000182 44 8 45 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_104041_1_758_+ FIG00000402 56 12 58 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_104099_350_758_- FIG00000116 27 8 29 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_104109_114_536_- FIG00104848 56 11 57 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_104117_478_717_- FIG00034392 16 4 18 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_104120_1_446_- FIG00000288 39 7 40 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_104123_269_758_- FIG00001088 13 5 14 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_104140_1_584_+ FIG00059211 136 20 136 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_104159_1_342_- FIG00000408 39 8 40 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_104162_176_715_+ FIG00002849 6 3 9 Putative predicted metal-dependent hydrolase Restriction-Modification System 3.x T2D_unique_104169_1_758_- FIG00137522 4 4 7 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) Chitin and N-acetylglucosamine utilization 2 T2D_unique_104175_158_758_- FIG00013339 59 10 61 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_104176_1_758_- FIG00031250 29 10 32 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_104211_274_717_+ FIG00018457 55 9 56 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_104265_1_629_+ FIG00003547 157 24 158 Transcriptional regulator in cluster with Zn-dependent hydrolase Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_104266_383_757_+ FIG00001469 17 4 19 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_104288_270_757_+ FIG00001385 5 3 6 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_104292_453_757_+ FIG00003460 86 12 86 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_104323_470_757_+ FIG00000149 42 7 43 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_104334_453_757_- FIG00000450 6 3 7 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_104336_1_757_- FIG00001280 115 23 139 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_104403_1_756_+ FIG00066643 86 15 88 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_104433_1_646_- FIG01304636 21 7 24 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_104450_1_183_- FIG00093180 21 4 22 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_104462_128_756_- FIG00041038 91 17 103 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_104465_93_464_- FIG00000163 48 8 50 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_104485_1_756_+ FIG00066575 31 12 34 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_104502_1_756_- FIG00000578 62 14 66 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_104519_1_756_- FIG00001011 126 18 127 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_104566_132_756_+ FIG00060517 9 4 11 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_104592_1_575_- FIG00002449 12 5 14 Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48) Exopolysaccharide Biosynthesis 1.0 T2D_unique_104612_311_756_+ FIG00000081 105 16 105 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_104699_1_261_+ FIG00034652 13 4 14 Beta-galactosidase small subunit (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_104708_1_162_+ FIG00000377 32 5 33 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_104734_1_755_- FIG01016270 73 13 74 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_104756_1_755_+ FIG00004172 180 27 181 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_unique_104766_1_755_+ FIG00000118 82 20 84 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_104785_59_755_- FIG00003381 165 27 165 L-cystine uptake protein TcyP L-Cystine Uptake and Metabolism 6.0 T2D_unique_104835_1_269_- FIG00000402 7 2 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_104835_338_754_- FIG00000207 39 8 41 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_104861_523_754_+ FIG00008490 51 8 52 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_104896_577_754_- FIG00001547 8 2 9 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_104966_1_754_- FIG00000139 74 16 75 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_104983_1_754_- FIG00001328 148 24 149 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_unique_104996_409_754_+ FIG00000194 94 13 94 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_105003_1_204_- FIG00001237 9 5 30 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_105031_149_754_+ FIG00008507 51 13 53 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_105046_7_753_- FIG00000404 70 15 72 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_105078_49_753_- FIG01260980 186 28 187 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_105079_59_753_+ FIG00229257 170 24 172 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_105098_118_432_- FIG00144025 80 12 80 Teichoic acid glycosylation protein Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_105102_20_753_- FIG00001518 60 15 62 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_105109_1_753_- FIG00001750 30 9 32 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_105146_1_495_+ FIG00018396 133 20 133 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_105151_464_753_- FIG00008455 68 10 68 Phosphonate ABC transporter permease protein phnE (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_105161_1_753_+ FIG00000317 8 4 10 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_105187_1_753_- FIG00003086 19 5 20 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_105196_1_201_- FIG00000376 15 5 16 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_105196_332_753_+ FIG00001546 68 11 74 Poly(glycerophosphate chain) D-alanine transfer protein DltD D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_105201_352_753_+ FIG00000396 11 6 15 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_105236_549_753_- FIG00000175 13 4 14 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_105255_610_752_+ FIG00001311 4 3 7 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_unique_105259_480_752_- FIG00000080 16 5 18 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_105294_1_212_- FIG00001636 51 8 51 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_unique_105298_1_632_+ FIG00006997 5 3 6 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_105307_271_752_- FIG00009628 23 6 24 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_105322_1_752_+ FIG00016566 38 10 43 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_105327_278_752_- FIG00034851 52 11 53 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_105369_1_192_- FIG00016514 3 2 5 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_105369_195_752_- FIG00000494 20 6 22 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_105384_307_752_- FIG00009682 39 10 41 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_105391_294_593_- FIG00001489 20 6 21 ribosomal protein L7Ae family protein Transcription factors bacterial 1 T2D_unique_105404_367_752_- FIG00000721 41 10 43 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_105447_1_345_+ FIG00133229 66 11 66 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_105477_614_752_- FIG00007514 33 5 33 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_105478_1_322_- FIG00016566 13 4 16 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_105484_1_751_+ FIG01260980 39 9 40 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_105516_1_727_+ FIG00130344 21 5 22 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_105548_1_751_- FIG00132839 190 29 190 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_105569_38_277_+ FIG00048014 59 8 59 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_105569_300_686_+ FIG00064110 48 11 52 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_105575_587_751_- FIG00134889 13 4 14 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_105582_1_751_+ FIG00000011 4 2 5 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_105590_1_751_- FIG00028203 33 9 41 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_105601_1_516_+ FIG00016888 119 18 119 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_105601_546_751_+ FIG00007373 15 5 17 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_105652_1_751_+ FIG00000147 10 7 13 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_105667_387_572_+ FIG00000409 5 2 6 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_unique_105680_28_561_- FIG00002395 145 21 145 Cysteinyl-tRNA synthetase related protein CBSS-261594.1.peg.788 1 T2D_unique_105689_1_750_+ FIG00049433 84 20 86 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_105695_1_750_- FIG00135469 37 7 39 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_105696_339_750_+ FIG00000448 103 16 104 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_105722_435_659_+ FIG00002328 11 4 12 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_105753_1_513_- FIG00000128 141 20 141 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_105775_1_750_+ FIG00000439 32 8 34 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_105781_1_210_+ FIG00134342 14 5 16 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_105785_1_285_- FIG00035627 24 6 29 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_105785_298_750_- FIG00001504 31 8 33 Serine--glyoxylate aminotransferase (EC 2.6.1.45) Serine-glyoxylate cycle 1 T2D_unique_105791_271_750_+ FIG00001062 27 7 29 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_unique_105817_509_694_+ FIG00122145 32 5 33 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_105836_1_328_+ FIG00136193 14 4 16 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_105843_584_750_+ FIG00074225 3 2 4 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_105869_1_447_+ FIG00001550 12 3 14 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_105870_127_750_- FIG00113099 38 10 39 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities CBSS-89187.3.peg.2957 1 T2D_unique_105897_416_750_- FIG00000312 20 8 21 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_105914_1_375_+ FIG00000146 41 8 44 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_105933_28_318_- FIG00018396 20 5 24 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_105935_1_501_+ FIG00000290 108 18 108 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_105936_122_749_+ FIG00138468 26 7 28 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_106006_1_420_+ FIG00018699 97 15 109 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_106007_1_749_- FIG00006092 8 5 12 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_106016_253_749_+ FIG00000450 45 10 47 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_106024_522_749_- FIG00001928 54 8 54 Cold shock protein CspC Cold shock, CspA family of proteins 1 T2D_unique_106037_372_749_- FIG00000188 50 10 51 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_106056_1_464_+ FIG00000764 12 3 13 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_106083_490_749_- FIG00001555 17 5 19 Cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Putative oxidase COG2907 9 T2D_unique_106094_1_739_+ FIG01298199 22 8 26 Transmembrane component STY3231 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_106120_390_749_+ FIG00001670 8 2 9 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_106138_1_554_- FIG00031250 19 6 21 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_106138_563_749_- FIG00000047 6 3 8 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_106153_1_621_+ FIG00006151 13 7 15 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_106233_1_748_+ FIG00047414 38 11 43 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_106263_1_399_+ FIG00000132 23 6 25 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_106291_458_748_+ FIG00001531 73 11 73 D-alanyl transfer protein DltB D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_106304_43_748_- FIG00687285 7 2 8 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_unique_106323_1_748_+ FIG00001188 34 9 36 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_106378_279_747_- FIG00000015 20 6 21 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_106387_1_241_- FIG00561498 62 9 62 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_106387_270_747_- FIG00000350 117 19 117 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_106484_464_747_+ FIG00011102 11 3 14 Nitrite reductase probable electron transfer 4Fe-S subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_unique_106487_338_747_+ FIG00000251 100 15 100 Nucleoside diphosphate kinase (EC 2.7.4.6) Purine conversions 4.1118100 T2D_unique_106490_110_747_+ FIG00004074 19 5 21 Ferredoxin-type protein NapG (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_106559_123_747_+ FIG00006151 93 19 94 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_106564_1_747_- FIG00009194 15 4 17 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_106589_1_271_+ FIG00003715 14 3 16 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_106626_1_484_+ FIG00000660 100 17 101 Cystathionine gamma-synthase (EC 2.5.1.48) Methionine Biosynthesis 8 T2D_unique_106632_1_746_+ FIG00003788 198 29 198 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_106699_1_711_+ FIG00000163 35 9 37 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_106738_592_746_+ FIG00025216 12 2 12 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_106750_1_662_+ FIG00000191 10 4 12 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_106773_1_746_+ FIG00006463 11 4 13 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_106775_1_404_- FIG00000738 36 7 37 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_106776_610_746_- FIG00000177 12 2 12 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_106806_484_746_- FIG00001960 7 2 8 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_106834_1_250_+ FIG00001036 44 8 45 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_106834_312_745_+ FIG00015316 91 15 92 Flp pilus assembly protein TadB Widespread colonization island 2 T2D_unique_106849_1_745_- FIG00000155 58 15 88 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_106871_1_181_- FIG00026750 8 2 11 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_unique_106872_62_412_- FIG00016187 16 3 18 Arginine utilization protein RocB Arginine and Ornithine Degradation 1.34 T2D_unique_106915_1_745_+ FIG01260980 13 5 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_106922_480_745_+ FIG00002239 6 3 8 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_106935_1_745_+ FIG00000114 19 5 32 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_106945_1_745_- FIG00000040 76 18 93 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_106948_133_745_- FIG01260980 38 11 40 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_106960_1_284_+ FIG00005237 11 3 12 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_106984_1_745_+ FIG00003433 15 5 17 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_106995_1_420_+ FIG00051439 89 16 89 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_106995_443_745_+ FIG00008077 71 11 71 Putative pheromone cAM373 precursor lipoprotein CamS Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_107002_543_745_+ FIG00004453 29 5 31 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_107010_1_629_- FIG00001088 32 8 36 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_107016_132_744_- FIG00133209 152 23 152 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_107031_1_744_- FIG00000380 33 11 34 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_107055_158_382_- FIG00008080 4 2 5 YafQ toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_107062_400_744_+ FIG00001675 59 11 59 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_107071_1_359_+ FIG01304636 25 6 26 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_107092_1_522_+ FIG00003672 79 14 80 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_unique_107106_1_744_- FIG00042616 143 22 144 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_107107_1_744_- FIG00000434 55 14 58 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_107109_1_627_+ FIG00016145 7 2 9 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_unique_107120_562_744_+ FIG01260980 27 5 27 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_107130_1_477_+ FIG00007328 37 7 39 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_107148_1_709_- FIG00038343 5 3 8 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_107149_1_672_- FIG01955782 31 8 34 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_107151_224_523_- FIG00000402 84 12 84 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_107152_618_744_- FIG00000487 10 3 11 ATP-dependent protease HslV (EC 3.4.25.-) Proteasome bacterial 1 T2D_unique_107175_1_744_+ FIG00000793 201 29 201 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_107197_1_511_+ FIG00000721 6 3 7 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_107215_412_744_- FIG00055715 4 2 5 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_107217_1_189_+ FIG00028476 43 7 43 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_107217_318_744_+ FIG00001452 81 15 82 Transcriptional repressor of the fructose operon, DeoR family Fructose utilization 1 T2D_unique_107224_1_682_+ FIG00075970 153 23 154 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_107241_1_294_+ FIG00011114 74 11 74 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_107241_326_743_+ FIG00104848 110 17 110 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_107272_1_447_- FIG00005243 18 4 20 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_107283_1_743_- FIG00004453 152 23 154 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_107293_478_743_+ FIG00000479 6 3 8 Zinc uptake regulation protein ZUR Zinc regulated enzymes 1 T2D_unique_107341_1_440_- FIG00001168 77 14 78 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_107344_1_743_+ FIG00001798 47 13 62 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_107360_1_348_+ FIG00015108 82 12 83 Substrate-specific component CbrT of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_107415_1_380_+ FIG00015338 79 12 79 D-beta-hydroxybutyrate permease Polyhydroxybutyrate metabolism 5.6 T2D_unique_107420_1_359_- FIG00050243 87 13 87 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_107432_378_647_+ FIG00047414 10 3 12 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_107456_85_742_- FIG00005172 68 17 69 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_107505_1_188_- FIG00000396 7 3 7 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_107505_251_742_- FIG00000539 31 5 34 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_107510_572_742_+ FIG00002463 3 2 4 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_107535_1_224_- FIG00002470 18 4 18 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_107551_1_540_+ FIG00018457 12 3 13 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_107561_173_742_- FIG00001436 114 18 114 GlpG protein (membrane protein of glp regulon) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_107586_1_530_- FIG00055715 96 17 98 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_107605_25_742_- FIG00000434 20 6 22 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_107678_1_742_+ FIG00132758 59 11 68 Beta-galactosidase large subunit (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_107692_1_742_+ FIG00010454 5 4 8 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_107700_1_742_- FIG00134486 109 20 109 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_107702_1_742_+ FIG00038920 74 16 75 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_107743_602_741_- FIG00000256 28 5 28 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_107762_1_741_- FIG00000185 75 14 77 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_107765_1_466_- FIG00006151 17 6 19 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_107769_1_230_- FIG00003433 3 2 4 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_107780_1_741_- FIG00132994 5 3 7 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_107819_163_741_- FIG00000542 47 9 48 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_107849_1_741_- FIG00140555 196 29 196 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_107866_1_573_+ FIG00011659 37 7 38 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_107879_187_741_- FIG00000140 22 5 23 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_107946_1_329_- FIG00000043 86 12 86 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_107946_364_741_- FIG00058830 89 15 89 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_107956_311_741_+ FIG00007137 14 4 15 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_107962_1_588_+ FIG00000001 18 5 20 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_107969_223_549_+ FIG00000328 10 4 12 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_107975_490_740_- FIG00138613 5 3 9 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.13.3) Aromatic Amin Catabolism 7 T2D_unique_107999_1_740_+ FIG00000368 111 17 113 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_108073_1_740_+ FIG00088067 14 8 25 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_108084_1_537_+ FIG00006046 31 8 33 CRISPR-associated RAMP Csm3 CRISPR-associated cluster 1 T2D_unique_108084_541_740_+ FIG00031731 3 2 4 CRISPR-associated RAMP protein, Csm4 family CRISPR-associated cluster 1 T2D_unique_108098_246_740_- FIG00008230 31 6 32 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_108100_37_740_- FIG00010508 42 15 45 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_108105_1_149_- FIG00011114 28 5 28 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_108127_1_225_+ FIG00000151 31 5 32 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_108127_282_740_+ FIG00067681 28 6 29 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_108128_1_740_+ FIG00005860 213 30 213 SusD, outer membrane protein Cellulosome 1.x T2D_unique_108129_536_740_+ FIG00067300 15 3 16 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_108143_1_740_- FIG00034293 87 16 89 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_108150_83_740_+ FIG00001676 18 5 20 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_108174_1_740_- FIG00000279 187 27 188 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_108179_120_740_- FIG00000494 47 10 48 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_108201_1_739_- FIG00000116 73 16 83 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_108236_1_739_+ FIG00020613 88 19 91 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_108262_1_550_+ FIG00092725 76 13 77 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Anaerobic respiratory reductases 3 T2D_unique_108274_1_260_+ FIG00001145 67 9 67 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_108274_276_739_+ FIG00029916 79 12 80 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_108286_179_739_- FIG00051439 18 7 19 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_108300_1_256_- FIG01321404 3 2 5 Probable glutamate/gamma-aminobutyrate antiporter cAMP signaling in bacteria 4.1007 T2D_unique_108303_572_739_- FIG00000087 19 4 20 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_108322_429_739_+ FIG00000402 20 4 21 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_108329_1_303_+ FIG00000303 49 10 50 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_108329_471_739_- FIG00000425 16 4 17 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_108378_1_177_- FIG00062547 6 3 8 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_108391_1_739_+ FIG00000341 83 16 85 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_108420_1_739_- FIG00000372 7 4 9 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_108435_24_739_+ FIG00031825 32 10 37 Hydrogen peroxide-inducible genes activator DNA-binding regulatory proteins, strays 1 T2D_unique_108447_175_378_+ FIG00000283 13 3 14 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_108495_1_738_+ FIG00000578 159 25 160 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_108508_1_738_+ FIG00001670 28 10 30 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_108512_1_182_- FIG00000793 9 3 12 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_108516_1_738_+ FIG00002541 23 16 99 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_108518_597_738_+ FIG00002857 19 5 19 Thiol peroxidase, Tpx-type (EC 1.11.1.15) Thioredoxin-disulfide reductase 2 T2D_unique_108542_1_386_- FIG00000146 111 15 111 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_108592_496_738_- FIG00093180 13 4 14 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_108627_1_199_+ FIG00139491 9 3 12 NAD-reducing hydrogenase subunit HoxE (EC 1.12.1.2) Hydrogenases 2 T2D_unique_108687_1_737_- FIG00046929 72 16 74 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_108726_319_737_+ FIG00000116 76 14 77 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_108742_111_737_- FIG00011114 90 18 91 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_108751_1_685_+ FIG00137972 190 27 190 Putative sucrose phosphorylase (EC 2.4.1.7) Maltose and Maltodextrin Utilization 1.x T2D_unique_108756_1_532_+ FIG00028203 23 9 26 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_108762_56_737_+ FIG00018457 5 5 7 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_108790_316_737_+ FIG00030688 108 16 108 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_108815_1_737_+ FIG00038343 6 3 8 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_108820_1_737_+ FIG00010285 14 3 16 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_108848_1_311_- FIG00000915 11 3 13 Hypothetical protein YaeJ with similarity to translation release factor Translation termination factors bacterial 1.13 T2D_unique_108881_1_737_+ FIG00026918 35 8 38 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_108887_1_737_- FIG01260980 214 29 214 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_108899_1_471_- FIG00001011 127 19 127 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_108902_437_724_+ FIG00008591 17 3 18 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_108911_1_162_- FIG00001548 5 2 6 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_108911_401_736_+ FIG00002130 8 3 10 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_108916_1_185_+ FIG00023369 33 5 34 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_108916_217_465_- FIG00017306 18 5 19 Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61) Bacterial Chemotaxis 9 T2D_unique_108917_1_398_- FIG00035627 35 8 36 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_108924_128_736_- FIG00000552 146 23 147 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_108935_1_736_+ FIG00000527 19 7 21 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_108941_519_736_+ FIG01304229 37 7 37 MSM (multiple sugar metabolism) operon regulatory protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_108946_1_736_- FIG00002414 53 14 55 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_unique_108953_1_478_+ FIG01290653 3 3 5 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_108955_205_736_+ FIG00002489 145 21 145 Spore germination protein GerKA Spore germination 1 T2D_unique_108959_1_736_+ FIG00003631 4 3 6 Glutamate--cysteine ligase (EC 6.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_108974_1_437_+ FIG00000915 63 11 64 Hypothetical protein YaeJ with similarity to translation release factor Translation termination factors bacterial 1.13 T2D_unique_108978_1_736_+ FIG00000070 86 19 91 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_108981_1_348_- FIG00000148 29 6 30 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_108983_1_547_+ FIG00000015 132 20 132 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_109016_1_669_+ FIG00000070 30 12 31 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_109020_1_274_+ FIG00016110 6 3 7 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_109023_545_736_- FIG00340352 34 6 35 Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase:Heavy metal translocating P-type ATPase Copper homeostasis 12 T2D_unique_109029_218_736_- FIG00000081 60 11 61 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_109075_1_736_+ FIG00340853 45 13 47 Oxalyl-CoA decarboxylase (EC 4.1.1.8) Glycolate, glyoxylate interconversions ? T2D_unique_109080_1_436_+ FIG00134889 97 16 97 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_109104_1_736_- FIG00079740 4 2 6 Xyloside transporter XynT Xylose utilization 1 T2D_unique_109139_1_735_+ FIG00554193 17 5 19 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_109242_1_735_+ FIG00046929 146 25 159 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_109262_1_735_- FIG00001065 135 23 150 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_109298_1_735_+ FIG00001094 57 14 59 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_109300_1_647_- FIG00021484 5 4 7 Metallo-beta-lactamase superfamily domain protein in prophage Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_109308_1_286_- FIG00059124 38 7 39 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_109324_233_735_- FIG00000283 99 14 100 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_109325_1_309_- FIG00000840 35 7 36 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_109325_331_735_- FIG00000015 19 5 21 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_109327_1_735_- FIG00038343 4 4 5 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_109328_1_735_+ FIG00000184 20 6 24 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_109416_1_390_- FIG00000811 22 5 24 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_109432_1_251_+ FIG00031731 5 2 6 CRISPR-associated RAMP protein, Csm4 family CRISPR-associated cluster 1 T2D_unique_109432_266_734_+ FIG00039969 3 2 5 CRISPR-associated protein, Csm5 family CRISPR-associated cluster 1 T2D_unique_109438_383_734_- FIG00000314 21 6 23 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_109439_91_734_- FIG00022899 85 17 86 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_109446_230_734_- FIG00000402 13 4 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_109460_52_309_- FIG00340292 31 5 32 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_109465_2_457_- FIG00077620 102 16 103 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_109484_1_734_+ FIG00011537 157 26 176 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_109488_1_607_- FIG00000404 123 23 124 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_109511_1_734_- 12 9 20 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_unique_109525_222_734_- FIG00000594 10 7 11 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_109530_508_734_+ FIG00000184 14 4 15 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_109536_1_266_- FIG00000212 6 4 7 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_109536_335_734_- FIG00000224 11 5 12 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_109552_1_492_+ FIG00001531 48 13 49 D-alanyl transfer protein DltB D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_109568_1_328_- FIG00000793 32 6 34 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_109568_363_733_- FIG00007031 19 4 22 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase (EC 2.5.1.-) Chorismate Synthesis 1 T2D_unique_109573_1_580_+ FIG00000226 133 21 135 GTP cyclohydrolase I (EC 3.5.4.16) type 1 Zinc regulated enzymes 1 T2D_unique_109574_1_733_- FIG00000040 127 24 128 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_109594_1_733_+ FIG00063189 96 22 101 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_109600_275_733_- FIG00006278 32 5 34 Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) CBSS-316057.3.peg.3521 1 T2D_unique_109604_1_176_- FIG00003801 26 4 27 type 1 fimbrae adaptor subunit FimF Type 1 pili (mannose-sensitive fimbriae) 1.x T2D_unique_109610_1_733_+ FIG00001011 7 4 9 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_109641_278_733_- FIG00000013 30 6 30 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_109713_1_417_- FIG00003788 5 2 7 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_109736_1_733_+ FIG00067681 33 8 36 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_109751_239_493_- FIG00006169 51 8 52 YoeB toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_109751_497_733_- FIG00006338 59 9 59 YefM protein (antitoxin to YoeB) Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_109761_1_186_+ FIG00000370 8 3 10 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_109775_462_733_+ FIG00008572 4 4 6 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_109809_1_732_+ FIG00000011 198 29 198 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_109812_131_732_- FIG00182617 16 6 18 Predicted alpha-L-rhamnosidase L-rhamnose utilization 1 T2D_unique_109825_109_408_- FIG01318398 7 3 8 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_109860_1_732_+ FIG00000011 35 7 38 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_109869_1_321_- FIG00004037 84 12 84 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_109869_335_732_- FIG00007514 73 11 74 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_109886_1_390_+ FIG00000130 103 15 103 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_109892_1_200_- FIG00076542 14 3 15 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_109892_425_732_+ FIG00009096 21 6 23 Galactosamine-6-phosphate isomerase (EC 5.3.1.-) N-Acetyl-Galactosamine and Galactosamine Utilization B.x T2D_unique_109922_1_600_+ FIG01007502 7 3 8 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_109932_368_732_- FIG00013638 19 5 20 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_109952_1_732_- FIG00001129 51 10 53 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_unique_109957_1_480_+ FIG00001893 70 12 71 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_109983_531_732_- FIG00066425 9 2 10 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_109999_1_220_+ FIG00000788 5 2 7 tRNA:Cm32/Um32 methyltransferase Flavohaemoglobin 1 T2D_unique_110036_1_404_+ FIG00000848 5 4 6 Manganese superoxide dismutase (EC 1.15.1.1) Oxidative stress 1.2 T2D_unique_110043_1_731_- FIG00018699 38 8 40 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_110058_1_731_+ FIG01304601 27 9 28 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_110123_1_731_+ FIG00008230 19 5 23 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_110140_547_731_+ FIG00000164 15 3 16 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_unique_110152_1_241_+ FIG00000309 28 6 29 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_110152_254_731_- FIG00080231 64 12 66 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_110153_1_443_+ FIG00002020 121 17 121 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_110153_449_731_+ FIG00138004 70 10 71 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_110166_156_539_+ FIG00000476 15 3 16 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_110204_1_240_+ FIG00000102 8 3 10 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_110209_1_731_+ FIG00075702 105 19 106 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_110229_1_223_+ FIG00022899 3 3 7 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_110303_1_730_- FIG00001548 33 10 35 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_110304_1_730_- FIG01304530 40 11 42 Phage terminase, large subunit Phage head and packaging 1 T2D_unique_110348_505_730_- FIG00000304 12 2 13 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_110358_1_272_+ FIG00079521 8 2 9 TRAP dicarboxylate transporter, DctM subunit, unknown substrate 8 CBSS-49338.1.peg.459 1 T2D_unique_110363_1_730_- FIG00074225 117 19 128 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_110417_1_730_- FIG00025086 124 22 125 Xanthine permease Purine Utilization 1 T2D_unique_110458_1_137_+ FIG00132976 6 2 7 Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33) Acetoin, butanediol metabolism 5 T2D_unique_110459_271_730_+ FIG00561498 128 19 128 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_110464_1_730_+ FIG00000015 37 11 39 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_110465_1_730_- FIG00001798 26 6 27 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_110471_2_667_- FIG00035634 7 2 9 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_110533_1_202_- FIG00000166 50 8 50 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_110533_205_411_- FIG00000409 45 7 46 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_unique_110533_414_730_- FIG00000155 68 12 68 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_110535_1_730_- FIG00000287 13 10 54 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_110549_386_729_+ FIG00000405 91 14 91 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_110563_323_622_- FIG00000557 7 3 8 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_110585_599_729_+ FIG00000372 14 3 14 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_110601_1_729_+ FIG00007059 41 10 42 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_110618_1_729_- FIG00000080 18 11 24 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_110627_1_453_+ FIG00000350 66 14 67 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_110627_465_729_+ FIG00024401 59 10 59 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_110680_1_548_+ FIG00002289 18 4 21 Soluble lytic murein transglycosylase precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_110699_298_729_- FIG00001106 94 16 95 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_110714_379_729_+ FIG00008490 7 2 9 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_110739_1_729_+ FIG00000011 11 4 13 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_110741_291_662_+ FIG00018536 45 9 46 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_110771_1_729_- FIG00001882 184 27 184 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_110784_1_425_- FIG00000476 13 5 14 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_110786_1_238_- FIG00067300 9 3 10 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_110788_1_204_- FIG00000332 19 3 19 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_110788_314_729_- FIG00000405 113 16 113 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_110839_391_728_+ FIG00005283 33 8 34 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_110842_1_334_- FIG00029916 83 13 83 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_110848_1_728_+ FIG00000439 89 18 98 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_110879_1_140_- FIG00011114 27 4 27 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_110879_159_728_- FIG00083946 121 21 121 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_110899_1_728_- FIG00006764 61 12 63 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_110948_142_540_+ FIG00000112 37 9 39 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_110959_1_728_- FIG00001649 3 4 5 N-methylhydantoinase A (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_110980_48_728_- FIG00120441 12 4 13 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_110999_392_728_- FIG00006691 8 2 10 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_111042_1_188_+ FIG00001209 35 7 35 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_unique_111062_1_371_- FIG00025527 5 3 9 Pyruvate dehydrogenase E1 component beta subunit (EC 1.2.4.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_111085_1_443_- FIG01297554 11 2 12 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_111093_1_727_+ FIG01260980 42 14 44 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_111108_1_727_- FIG01318398 5 3 6 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_111111_1_727_+ FIG00085740 66 14 69 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_111141_598_727_+ FIG00074225 4 2 5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_111157_140_727_- FIG00000187 148 23 148 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_111176_33_677_- FIG00138908 154 24 154 Flavin reductase (EC 1.5.1.30) Hemin transport system 1 T2D_unique_111198_343_727_+ FIG00003535 67 12 79 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_111223_12_727_- FIG00055715 86 18 87 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_111230_1_633_+ FIG01959790 5 2 7 Periplasmic aromatic aldehyde oxidoreductase, FAD binding subunit YagS Purine Utilization 1 T2D_unique_111242_227_727_- FIG00075970 10 3 11 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_111244_523_727_+ FIG00034851 16 6 18 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_111274_1_414_+ FIG00001036 96 15 97 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_111279_300_727_+ FIG00107349 114 16 114 Glycine/sarcosine/betaine reductase component C chain 1 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_111284_46_432_- FIG00044478 14 5 16 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_111370_1_726_+ FIG01260980 210 29 210 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_111371_1_726_- FIG00036224 174 27 174 Sialidase (EC 3.2.1.18) Sialic Acid Metabolism 1.x T2D_unique_111374_1_726_+ FIG00000241 177 28 177 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_111385_1_426_+ FIG00047509 110 16 110 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_111398_512_726_- FIG00001449 17 3 18 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_unique_111436_280_687_+ FIG00039528 83 11 84 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) Purine conversions 4.1118100 T2D_unique_111443_1_726_+ FIG00080231 21 7 24 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_111486_1_726_- FIG00719736 172 27 173 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_111510_1_198_- FIG00000402 44 8 44 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_111534_1_725_+ FIG00000578 6 3 8 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_111546_67_510_+ FIG00001132 69 14 70 LSU ribosomal protein L16p (L10e) Ribosome LSU bacterial 9 T2D_unique_111593_46_725_+ FIG00000645 49 9 51 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_111619_1_725_- FIG00000309 94 18 96 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_111627_1_439_+ FIG00000168 40 9 41 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_111638_1_725_+ FIG00002239 187 28 189 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_111655_126_725_+ FIG00000377 35 8 38 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_111661_1_725_- FIG00719736 7 7 14 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_111668_438_725_- FIG00001406 73 11 73 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_111674_247_725_- FIG00058998 20 6 23 Vancomycin response regulator VanR Resistance to Vancomycin X T2D_unique_111677_389_725_- FIG00001407 5 4 11 FKBP-type peptidyl-prolyl cis-trans isomerase fklB (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_111689_1_725_- FIG00001548 32 8 34 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_111720_1_725_+ FIG00009682 110 21 111 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_111752_1_725_+ FIG00000422 169 26 169 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_111758_445_725_- FIG00001076 30 6 31 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_111773_1_428_- FIG00000194 56 13 57 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_111778_1_164_+ FIG00035634 11 3 12 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_111801_1_724_+ FIG00000168 33 8 35 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_111809_1_342_- FIG00023369 23 5 25 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_111814_1_724_+ FIG00028461 91 19 94 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_111816_585_724_- FIG00000011 15 3 16 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_111894_1_256_+ FIG00108342 51 8 52 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_111930_1_412_+ FIG00003460 11 3 13 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_111956_400_724_+ FIG00001882 66 10 66 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_112047_436_723_+ FIG01298199 71 10 71 Transmembrane component STY3231 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_112068_1_723_- FIG00002560 97 14 99 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_112101_178_423_+ FIG00059211 4 2 5 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_112119_1_723_+ FIG00000032 86 18 88 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_112145_1_723_+ FIG00000402 37 8 40 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_112146_1_723_- FIG00000056 69 18 70 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_112163_1_331_- FIG00032749 33 7 35 Protein YicC CBSS-323097.3.peg.2594 1 T2D_unique_112207_119_723_- FIG01016270 30 8 32 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_112224_1_165_- FIG00135639 39 6 39 Purine trans deoxyribosylase (Nucleoside deoxyribosyltransferase-I) (EC 2.4.2.6) Purine conversions 4.1118100 T2D_unique_112236_111_723_+ FIG00000402 5 3 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_112277_1_722_- FIG00050603 68 15 69 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_112299_1_722_+ FIG00135554 44 13 48 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_112302_398_722_- FIG00000108 31 6 33 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_112343_1_204_+ FIG00000224 46 8 46 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_112344_304_722_+ 14 3 16 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_112357_329_722_- FIG00130344 41 9 43 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_112375_521_722_- FIG00003394 9 3 11 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_112377_139_722_+ FIG00000261 115 18 122 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_112378_375_722_- FIG00035175 78 13 78 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_112383_1_528_- FIG00000207 34 7 36 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_112395_1_722_- FIG00008230 23 7 48 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_112434_1_401_- FIG00000455 5 2 7 Malate dehydrogenase (EC 1.1.1.37) Serine-glyoxylate cycle 1 T2D_unique_112461_228_722_- FIG00000112 47 10 49 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_112551_1_721_- FIG00000001 165 27 166 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_112554_174_721_+ FIG00046929 136 21 136 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_112564_147_721_- FIG00001448 19 5 21 Phosphoadenylyl-sulfate reductase [thioredoxin] (EC 1.8.4.8) Cysteine Biosynthesis 2.17 T2D_unique_112577_1_721_- FIG00000504 103 19 104 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_112615_18_533_- FIG00000121 43 9 45 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_112636_1_721_+ FIG00000824 38 11 41 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_112656_1_435_+ FIG00023004 98 15 100 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_112672_447_721_+ FIG00000738 13 4 14 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_112694_1_382_+ FIG00006609 24 6 27 Nickel transport ATP-binding protein NikE (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_112701_87_721_+ FIG00066643 76 14 78 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_112724_1_721_- FIG00000191 130 25 132 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_112735_1_534_+ FIG00000088 8 3 10 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_112749_352_696_+ FIG00004334 25 5 27 CRISPR-associated protein Cas2 CRISPRs 1 T2D_unique_112778_1_404_+ FIG00002847 35 7 39 HflK protein Hfl operon 1.111 T2D_unique_112778_416_720_+ FIG00018201 26 7 27 HflC protein Hfl operon 1.111 T2D_unique_112814_1_719_+ FIG00000402 201 28 201 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_112860_408_720_+ FIG00000148 49 11 50 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_112870_1_545_+ FIG00000065 138 21 138 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_112871_553_720_+ FIG00024930 3 2 4 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_112895_52_720_- FIG00000118 10 4 12 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_112912_36_329_- FIG00002328 18 4 19 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_112912_391_720_- FIG00000025 44 9 45 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_112915_448_720_+ FIG00051439 9 3 10 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_112941_1_140_+ FIG00005172 11 2 13 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_112941_239_720_+ FIG00020185 57 10 59 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_112944_1_720_- FIG00025216 12 6 18 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_112972_515_720_- FIG00001548 19 3 20 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_112979_254_719_- FIG01260980 8 3 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_113017_1_719_+ FIG00000412 25 9 36 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_113019_1_253_- FIG00005479 8 3 9 Transcriptional repressor for NAD biosynthesis in gram-positives NAD and NADP cofactor biosynthesis global E T2D_unique_113030_1_151_- FIG00001505 14 4 15 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_113045_1_719_- FIG00004078 18 9 44 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_113073_1_706_+ FIG00037240 32 8 33 Alpha-N-arabinofuranosidase 2 (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_113078_1_679_- FIG01260980 168 24 169 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_113101_197_719_+ FIG00001548 126 17 127 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_113112_452_719_- FIG00002509 53 9 54 Glutathione S-transferase, omega (EC 2.5.1.18) CBSS-89187.3.peg.2957 1 T2D_unique_113114_404_719_- FIG00000080 6 3 7 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_113122_1_719_- FIG00136866 60 12 62 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_113128_248_719_- FIG00000402 71 12 72 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_113135_1_702_+ FIG00011468 36 9 38 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_113152_1_539_+ FIG00003460 53 9 55 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_113191_338_719_- FIG00002344 25 9 26 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_113198_174_719_- FIG00010285 129 20 130 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_113283_70_718_- FIG00000290 40 8 51 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_113309_1_370_- FIG00000269 74 12 75 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_113339_1_365_- FIG00001106 100 14 100 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_113350_362_718_- FIG00041038 22 5 23 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_113367_1_718_+ FIG00004788 58 11 59 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_113450_315_717_+ FIG00002574 42 10 45 2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37) Phosphonate metabolism 1 T2D_unique_113461_1_717_+ FIG00000532 52 11 55 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_113464_293_717_- FIG00000659 30 7 32 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_113466_1_518_+ FIG00007157 17 7 18 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_113519_1_717_- FIG00000422 189 28 189 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_113589_1_588_+ FIG00002387 64 10 65 Phosphatidylglycerophosphatase B (EC 3.1.3.27) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_113594_1_314_- FIG01954097 3 2 6 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_113594_430_717_- FIG00006128 47 7 48 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_113600_288_717_- FIG00045393 13 5 15 Dipeptide transport ATP-binding protein DppF (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_113622_1_717_- FIG00041038 11 5 13 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_113625_1_717_- FIG00041038 42 12 43 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_113632_1_717_- FIG00001561 63 14 68 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_113665_1_208_- FIG00000372 24 4 25 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_113694_1_219_- FIG00000434 39 7 39 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_113694_549_717_+ FIG00000134 43 6 43 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_113703_1_717_- FIG00000025 129 19 131 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_113718_1_717_+ FIG00138538 111 22 142 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_113727_100_717_- FIG00000040 40 12 42 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_113755_1_716_+ FIG00000111 71 14 79 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_113780_265_716_+ FIG00007960 48 10 50 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_113805_1_371_+ FIG00008490 46 10 47 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_113814_98_716_- FIG00000308 64 12 66 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_113853_1_179_- FIG00000645 10 2 12 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_113853_233_716_- FIG00076542 10 4 13 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_113874_1_716_+ FIG01260980 94 19 96 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_113900_453_716_- FIG00000258 49 9 49 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_113922_1_716_- FIG00037431 39 11 41 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_113938_1_147_- FIG00001882 32 5 32 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_113950_1_622_+ FIG00001968 88 14 89 PTS system, mannose-specific IIB component (EC 2.7.1.69) Sialic Acid Metabolism 1.x T2D_unique_113958_1_716_- FIG00038920 23 7 25 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_114021_195_715_+ FIG00014990 125 20 125 Similar to ribosomal large subunit pseudouridine synthase D, Bacillus subtilis YjbO type CBSS-222523.1.peg.1311 1 T2D_unique_114048_212_715_- FIG00004453 18 5 19 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_114085_1_715_+ FIG00000260 40 11 42 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_114086_120_715_+ FIG00016528 134 23 135 Nickel transport ATP-binding protein nikD2 (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_114134_1_514_- FIG00000494 17 4 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_114152_233_715_- FIG00007586 8 4 10 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_114212_1_264_- FIG00002847 3 2 4 HflK protein Hfl operon 1.111 T2D_unique_114231_1_715_- FIG00000467 67 13 70 Biotin synthase (EC 2.8.1.6) Biotin biosynthesis 1X T2D_unique_114274_19_714_+ FIG00000402 91 17 92 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_114276_1_227_- FIG00000332 36 5 37 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_114288_316_714_+ FIG00132820 5 3 7 Arogenate dehydrogenase (EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_114312_238_714_- FIG00012037 43 8 46 heterodisulfide reductase, iron-sulfur binding subunit, putative Anaerobic respiratory reductases 3 T2D_unique_114349_238_714_+ FIG00000350 46 11 47 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_114352_420_714_+ FIG00133325 62 10 62 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_114358_256_714_- FIG00086220 120 17 120 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_114408_558_714_- FIG00000504 9 2 10 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_114426_1_714_- FIG00035175 28 12 55 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_114447_374_714_+ FIG00000325 69 12 69 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_114455_1_623_- FIG00007714 128 20 129 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_114490_299_714_- FIG00000680 78 14 79 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_114501_168_554_- FIG00031250 6 2 8 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_114502_211_714_- FIG00000112 5 4 6 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_114504_349_519_+ FIG00088996 14 3 16 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_unique_114513_1_510_+ FIG00005111 6 5 15 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_unique_114518_41_628_- FIG00000221 45 7 47 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_114533_274_713_+ FIG00061832 52 10 53 Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) Sialic Acid Metabolism 1.x T2D_unique_114535_1_282_+ FIG00000803 5 4 12 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_unique_114557_1_713_+ FIG00000341 105 20 106 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_114593_1_481_- FIG00000356 102 17 103 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_114610_528_713_- FIG00001550 7 3 8 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_114614_380_713_+ FIG00003378 46 8 47 [NiFe] hydrogenase metallocenter assembly protein HypE NiFe hydrogenase maturation 1 T2D_unique_114636_436_713_- FIG00000038 8 3 10 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_114642_1_276_+ FIG00001385 4 2 5 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_114662_1_713_+ FIG00017431 18 7 20 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_unique_114704_1_298_+ FIG00000822 53 9 54 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_114711_1_713_+ FIG00140555 205 28 205 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_114719_582_713_+ FIG00000895 31 5 31 Alanine dehydrogenase (EC 1.4.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_114794_413_571_- FIG00000494 11 3 12 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_114796_384_712_- FIG00007941 20 6 21 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_114828_1_712_+ FIG00138182 41 9 43 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_114854_1_712_- FIG00340292 14 7 18 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_114890_1_548_+ FIG00135469 6 3 8 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_114910_1_351_+ FIG00007960 39 9 40 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_114923_52_712_- FIG00001168 24 10 28 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_114986_1_203_- FIG00084105 20 5 23 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_114996_1_712_+ FIG00000097 25 5 27 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_115035_1_711_+ FIG00000539 192 27 193 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_115084_1_684_- FIG00000376 159 25 160 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_115110_88_711_- FIG00005698 86 17 89 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_115130_54_215_+ FIG00038456 14 3 14 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_115160_1_711_- FIG00002320 103 18 116 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_unique_115210_1_711_+ FIG00000962 12 4 14 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_115266_1_710_+ FIG00034851 36 10 38 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_115268_246_710_- FIG00018457 48 11 50 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_115326_294_710_+ FIG00037431 9 4 10 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_115341_1_710_- FIG00003506 4 2 5 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_115352_1_391_+ FIG00000148 42 8 43 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_115388_136_710_+ FIG00018396 6 5 27 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_115433_1_143_- FIG00000159 27 5 27 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_115453_1_710_+ FIG00038814 17 7 22 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_115493_368_710_+ FIG00000601 35 8 37 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_115503_313_709_- FIG00000114 23 6 25 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_115511_87_709_- FIG00019251 6 4 8 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_115538_1_192_+ FIG00002385 22 5 24 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_115567_1_709_+ FIG00001469 12 6 15 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_115585_1_278_- FIG00000113 26 7 27 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_115602_28_387_- FIG00000899 45 11 46 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_115610_1_532_- FIG00000333 138 20 138 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_115632_274_709_+ FIG00089870 36 7 37 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_unique_115637_167_709_- FIG00051439 19 7 25 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_115640_1_197_- FIG00000770 34 6 37 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_115661_1_196_- FIG00003439 4 2 5 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_115661_406_709_- FIG00000476 24 6 25 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_115689_1_709_- FIG00000555 54 11 55 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_115760_1_137_- FIG00009956 11 2 12 RNA:NAD 2'-phosphotransferase tRNA splicing 1 T2D_unique_115780_1_708_- FIG00139192 25 9 28 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_115794_473_708_+ FIG00561498 10 3 12 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_115796_161_708_- FIG00012945 10 5 17 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_115799_1_330_- FIG00051439 73 12 73 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_115801_1_708_+ FIG00052605 25 7 26 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_115882_1_708_- FIG00000738 196 28 196 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_115905_1_708_+ FIG00019251 69 16 71 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_115948_281_568_+ FIG00010600 47 7 47 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_115970_1_708_+ FIG00012267 7 4 9 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_115974_1_291_- FIG00000520 65 10 66 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_115978_1_675_+ FIG00032178 72 17 74 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_115999_243_707_+ FIG00001635 38 8 39 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_116037_1_707_- FIG00060517 53 15 55 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_116057_4_707_- FIG00016132 193 27 194 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_unique_116081_1_302_- FIG00006046 7 2 8 CRISPR-associated RAMP Csm3 CRISPR-associated cluster 1 T2D_unique_116085_1_387_+ FIG00125395 60 11 61 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_116094_120_350_- FIG01955857 6 3 7 Sensor protein of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_unique_116123_1_707_- FIG00001732 89 14 90 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_116124_1_707_- FIG00051161 11 6 14 3'-phosphoadenosine 5'-phosphosulfate sulfurtransferase DndC DNA phosphorothioation 1 T2D_unique_116135_126_707_- FIG00000402 158 23 158 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_116141_1_707_- FIG00001198 5 2 6 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_116160_1_505_+ FIG01260980 23 8 29 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_116166_205_707_+ FIG00020897 60 13 62 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_116176_1_298_- FIG00000721 29 6 30 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_116201_179_382_- FIG00067562 26 4 28 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_116210_1_707_- FIG01260980 8 5 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_116222_1_707_- FIG00000101 88 16 90 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_116224_17_707_- FIG00630216 202 28 202 Pheromone response surface protein PrgC Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_116234_233_707_- FIG00005924 14 6 27 Excinuclease ABC subunit A paralog in greater Bacteroides group DNA repair, UvrABC system 1 T2D_unique_116243_1_707_+ FIG00000477 95 21 96 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_116288_1_706_+ FIG00000412 179 27 179 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_116328_1_706_+ FIG00000404 70 13 71 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_116375_478_706_- FIG00127025 11 3 12 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_116382_1_706_- FIG00000494 37 8 39 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_116388_344_706_+ FIG01260980 6 4 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_116426_1_706_+ FIG00001548 15 10 57 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_116432_1_486_- FIG00000913 93 16 93 Ribonuclease E (EC 3.1.26.12) RNA processing and degradation, bacterial 1 T2D_unique_116432_563_706_- FIG00042267 8 2 9 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_116467_578_706_+ FIG00000146 17 3 18 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_116502_144_356_- FIG01292786 8 4 9 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_116519_1_705_- FIG00009149 53 15 54 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_116591_1_324_+ FIG00000309 57 10 58 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_116591_434_705_+ FIG00001469 32 7 33 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_116643_1_518_+ FIG00002560 7 4 9 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_116643_534_705_+ FIG00140555 10 3 10 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_116684_509_705_+ FIG00009149 21 6 23 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_116696_1_541_- FIG00090765 97 15 98 Lactose and galactose permease, GPH translocator family Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_116698_187_705_+ FIG00130344 140 20 140 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_116735_1_705_+ FIG00000069 133 24 133 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_116740_1_649_+ FIG00000130 164 26 164 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_116779_40_704_- FIG00000395 66 14 67 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_116789_382_704_- FIG00000001 53 11 54 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_116794_1_704_- FIG00000043 53 15 55 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_116827_1_259_+ FIG00006463 60 10 60 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_116842_1_564_+ FIG00001865 151 22 151 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_116869_1_704_- FIG00001687 87 17 89 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_116885_362_704_- FIG00019456 16 3 18 Xylose isomerase (EC 5.3.1.5) Xylose utilization 1 T2D_unique_116929_1_704_- FIG00008342 61 13 63 Anaerobic sulfite reductase subunit A Anaerobic respiratory reductases 3 T2D_unique_116977_84_704_- FIG00000112 171 25 171 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_116979_1_285_- FIG00000695 35 7 36 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_116980_234_704_+ FIG00001385 4 2 5 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_117012_1_235_+ FIG00009395 51 8 51 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_unique_117012_386_704_+ FIG00000782 64 12 64 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_117013_135_704_+ FIG01956038 6 2 9 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_unique_117085_1_479_- FIG00000350 26 8 28 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_117091_295_703_+ FIG00031731 8 2 9 CRISPR-associated RAMP protein, Csm4 family CRISPR-associated cluster 1 T2D_unique_117115_1_689_+ FIG00719736 155 26 155 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_117125_277_537_- FIG01954533 6 2 7 Phosphocarrier protein of PTS system Fructose utilization 1 T2D_unique_117144_243_703_- FIG00475203 58 12 59 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_117173_159_703_+ FIG00000157 95 18 97 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_117194_231_703_- FIG00003580 19 4 20 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_117195_1_241_+ FIG00001022 17 5 18 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_117233_1_703_+ FIG00028694 29 8 30 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_117235_1_703_+ FIG00132586 128 20 129 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_117245_190_703_+ FIG00000290 13 6 15 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_117262_1_468_- FIG00002020 13 7 15 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_117270_1_236_- FIG00000176 18 4 19 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_117282_1_703_- FIG00000097 14 5 22 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_117329_1_561_+ FIG00003435 146 22 146 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_117334_1_702_- FIG00001440 29 6 31 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_117361_1_702_- FIG00000308 29 7 30 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_117362_1_214_+ FIG01304601 19 5 20 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_117363_30_702_+ FIG00000338 8 3 15 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_117365_1_580_- FIG00000113 11 4 14 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_117382_1_702_- FIG00000392 31 7 33 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_117383_1_702_+ FIG00475203 16 5 22 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_117407_1_356_- FIG00134167 42 7 43 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_117435_235_702_- FIG00006953 74 13 76 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_unique_117462_492_702_- FIG00034293 26 5 27 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_117491_1_611_- FIG00000695 60 10 62 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_117495_189_665_+ FIG00000720 22 5 24 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_117506_1_395_- FIG00058189 67 12 68 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_unique_117520_1_585_- FIG00004021 10 4 13 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_117541_1_702_- FIG00132586 106 20 108 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_117554_418_702_- FIG01961517 13 4 14 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_117571_1_177_+ FIG00000111 9 3 10 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_117573_1_240_- FIG00000333 57 8 58 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_117577_331_702_- FIG00121995 88 13 88 L-lactate dehydrogenase (EC 1.1.2.3) L-rhamnose utilization 1 T2D_unique_117579_141_702_- FIG00002487 71 13 82 Heptaprenyl diphosphate synthase component II (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_117599_1_702_- FIG00000333 20 4 22 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_117625_1_701_- FIG01955774 129 23 131 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_117643_1_195_+ FIG01290653 16 4 18 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_117658_1_701_- FIG00134486 13 9 21 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_117665_1_282_+ FIG00041382 38 6 39 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_117665_290_613_+ FIG00003712 8 2 9 Fe-S-cluster-containing hydrogenase components 1 Anaerobic respiratory reductases 3 T2D_unique_117676_1_701_+ FIG00000338 90 14 91 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_117716_6_176_- FIG00067300 10 2 11 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_117730_1_450_- FIG00058830 80 13 81 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_117736_1_701_+ FIG00000140 74 16 77 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_117745_1_223_+ FIG00000149 19 4 20 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_117757_252_701_+ FIG00003555 5 2 6 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_117763_1_701_+ FIG00014764 11 3 12 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_117794_1_172_- FIG00000092 7 3 8 LSU ribosomal protein L31p Ribosome LSU bacterial 9 T2D_unique_117805_1_701_+ FIG00000494 11 2 13 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_117825_1_641_- FIG00000404 165 25 166 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_117830_1_160_+ FIG01266244 10 2 11 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_117839_1_512_+ FIG00000494 12 6 14 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_117862_240_700_- FIG00060517 33 8 34 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_117871_1_700_+ FIG00000422 17 6 19 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_117876_318_700_+ FIG00008572 21 6 22 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_117883_1_434_+ FIG00132839 16 5 17 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_117903_1_700_+ FIG00008941 67 14 68 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_117921_58_700_+ FIG00014849 114 17 115 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_117965_356_700_- FIG00011380 44 8 45 putative glycosyltransferase - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide Rhamnose containing glycans 4.1 T2D_unique_117994_1_700_- FIG00016110 127 23 128 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_118012_1_167_- FIG00000578 3 3 4 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_118012_193_648_- FIG00000380 43 9 44 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_118029_1_347_- FIG00000235 23 7 24 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_118055_1_700_- FIG00080231 56 13 58 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_118060_325_624_+ FIG00140555 25 5 26 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_118090_401_700_- FIG00009229 28 6 30 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_118097_57_700_- FIG00001402 6 4 8 Helicase loader DnaI DNA-replication 4 T2D_unique_118114_1_189_- FIG00000013 9 2 10 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_118150_1_699_- FIG00006336 198 28 198 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_118153_91_699_- FIG00034973 169 24 169 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_unique_118173_377_699_- FIG00001960 85 13 85 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_118190_1_182_- FIG00000202 38 6 38 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_118197_1_268_- FIG00001358 20 5 21 Error-prone, lesion bypass DNA polymerase V (UmuC) DNA repair, bacterial UmuCD system 3 T2D_unique_118198_204_699_- FIG00014907 19 7 22 Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_118251_1_486_+ FIG00133325 18 4 19 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_118251_519_699_+ FIG00077620 17 4 18 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_118268_1_227_+ FIG01260980 8 3 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_118305_432_699_+ FIG00007514 5 2 6 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_118324_1_699_- FIG00000527 24 6 28 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_118336_1_699_- FIG00093180 16 7 19 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_118361_1_699_- FIG01292786 38 13 40 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_118367_253_699_+ FIG00001469 43 9 44 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_118382_1_247_+ FIG00067300 58 8 58 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_118389_1_698_+ FIG00003465 171 24 172 Outer membrane protein A precursor Osmoregulation 1 T2D_unique_118416_1_698_- FIG00009194 18 6 20 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_118445_448_698_- FIG00000287 55 9 55 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_118459_4_534_- FIG00598409 53 9 55 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_118505_1_698_- FIG00063189 156 25 156 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_118506_405_698_+ FIG00000241 53 9 54 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_118531_1_698_- FIG00066425 8 5 9 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_118540_74_698_- FIG00022300 110 19 111 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_118541_274_698_+ FIG00000176 7 5 21 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_118549_1_455_- FIG00000205 42 6 43 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_118591_28_698_- FIG00000107 31 10 33 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_118594_1_698_+ FIG00129616 169 26 169 GTP-binding protein EngA Universal GTPases 2 T2D_unique_118617_543_698_+ FIG00001463 20 3 20 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA precursor (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_118627_1_697_- FIG00028203 155 24 155 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_118658_115_420_- FIG00002470 8 3 9 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_118662_104_697_+ FIG00000011 135 22 141 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_118664_2_697_- FIG00000343 22 8 24 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_118666_1_456_+ FIG00000190 8 4 10 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_118666_484_697_+ FIG00064110 4 2 5 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_118670_1_574_- FIG00000038 60 12 62 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_118671_1_458_+ FIG00000402 42 8 44 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_118688_1_311_+ FIG00003751 69 11 70 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_118706_1_674_+ FIG00000721 41 9 44 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_118742_1_583_+ FIG00001732 129 19 130 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_118891_1_697_+ FIG00006463 9 2 11 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_118899_149_697_+ FIG01260980 7 5 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_118923_279_696_+ FIG00070513 81 15 82 phosphotransbutyrylase (EC 2.3.1.19) Acetyl-CoA fermentation to Butyrate A T2D_unique_118946_1_547_- FIG00028694 37 10 43 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_118962_1_354_- FIG00135315 89 14 89 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_118963_315_696_+ FIG00001168 87 14 87 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_119002_1_696_- FIG00001469 175 26 175 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_119003_243_696_- FIG00130900 25 8 27 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_unique_119024_154_612_- FIG01304043 103 16 104 Competence/damage-inducible protein CinA CBSS-257314.1.peg.676 4.x T2D_unique_119026_1_598_+ FIG00001346 96 17 97 Cystathionine gamma-lyase (EC 4.4.1.1) Methionine Degradation 3 T2D_unique_119061_1_696_+ FIG00003788 92 17 93 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_119073_1_696_- FIG00000011 11 6 14 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_119112_1_192_- FIG00003460 17 5 20 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_119217_65_695_- FIG00013156 14 6 16 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_119312_1_695_+ FIG00106349 81 18 82 Putative N-acetylgalactosaminyl-diphosphoundecaprenol glucuronosyltransferase Teichuronic acid biosynthesis 9 T2D_unique_119317_311_695_+ FIG00846773 3 2 4 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_119374_353_695_+ FIG00028203 14 3 15 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_119424_1_481_- FIG00003788 42 9 44 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_119465_1_493_- FIG00000241 21 6 22 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_119494_143_694_- FIG00000080 119 18 120 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_119571_1_370_- FIG00000621 3 2 5 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_119600_5_694_+ FIG00000212 37 12 40 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_119619_1_417_+ FIG01260980 7 3 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_119637_1_676_+ FIG00034851 17 6 20 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_119666_1_426_- FIG00000445 12 2 13 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_119667_1_270_+ FIG00052300 15 5 16 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_119672_135_694_+ FIG00004764 29 8 42 Ammonium transporter Ammonia assimilation 1 T2D_unique_119681_1_694_+ FIG00000842 19 9 26 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_119694_1_144_+ FIG00000097 18 3 19 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_119701_1_615_+ FIG01304601 22 4 24 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_119720_1_346_- FIG00031969 4 3 8 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_119722_1_694_- FIG00000532 40 8 42 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_119738_229_694_- FIG00002354 37 9 39 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_119766_1_223_- FIG00020185 27 6 29 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_119769_1_220_- FIG00005283 18 3 19 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_119795_281_622_- FIG00017454 10 4 12 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_119801_1_387_- FIG00085740 4 4 8 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_119809_43_693_+ FIG00010194 9 5 16 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_119828_338_693_+ FIG00002354 21 5 23 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_119834_1_693_+ FIG00011659 55 11 56 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_119870_1_191_+ FIG00000126 28 5 29 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_119872_1_237_+ FIG00007495 42 6 43 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_119895_1_134_- FIG00089051 4 2 8 Small acid-soluble spore protein, beta-type SASP Small acid-soluble spore proteins 1 T2D_unique_119904_1_226_+ FIG00126843 29 5 30 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_119933_476_693_+ FIG00000350 6 3 8 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_119944_1_693_+ FIG00000380 58 10 60 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_120003_1_693_- FIG00058830 202 27 202 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_120008_530_693_+ FIG00000260 19 4 20 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_120022_1_195_+ FIG00000303 17 5 18 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_120032_1_489_+ FIG00018369 46 9 47 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_120090_15_692_- FIG00000721 66 16 67 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_120166_1_692_+ FIG00044622 26 6 36 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_120209_1_485_- FIG00001653 24 8 27 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_120234_1_657_- FIG00028476 9 4 11 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_120254_40_516_- FIG00000973 9 3 11 RNA polymerase sigma factor RpoE Transcription initiation, bacterial sigma factors 1 T2D_unique_120261_1_692_+ FIG00005698 14 7 15 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_120274_422_692_+ FIG00000309 10 2 11 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_120276_1_692_+ FIG00016514 45 10 47 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_120300_49_692_+ FIG00000350 61 12 63 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_120326_1_691_- FIG00000038 86 18 88 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_120337_285_691_+ FIG00002020 103 16 103 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_120351_48_691_- FIG00002839 22 7 23 MutS-related protein, family 1 DNA repair, bacterial MutL-MutS system 1 T2D_unique_120372_1_691_- FIG00140555 184 27 185 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_120373_1_300_+ FIG00007086 44 7 44 Substrate-specific component CbiM of cobalt ECF transporter ECF class transporters 345678 T2D_unique_120383_1_438_+ FIG00058830 108 16 109 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_120386_1_691_- FIG00000335 89 17 90 Twin-arginine translocation protein TatC Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_unique_120408_344_691_- FIG00000329 9 5 26 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_120410_528_691_+ FIG00003715 17 4 18 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_120411_78_491_- FIG00000621 20 7 22 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_120445_1_261_- FIG00003769 18 3 19 Stage III sporulation protein AE Sporulation Cluster III A 1.x T2D_unique_120463_1_691_- FIG01260980 34 11 38 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_120464_1_232_- FIG00023369 14 6 15 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_120471_11_691_- FIG00062054 4 2 6 Putative glycosyltransferase protein CBSS-258594.1.peg.3339 1 T2D_unique_120506_1_691_+ FIG00000434 155 26 155 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_120518_1_566_- FIG00554193 52 11 56 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_120524_24_410_- FIG00088996 83 13 84 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_unique_120567_1_691_- FIG00018457 3 3 5 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_120584_1_571_+ FIG00001366 26 11 28 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_120599_1_215_- FIG00000356 54 8 54 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_120603_123_690_- FIG00001054 86 18 88 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_120613_412_690_- FIG00001166 57 9 57 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_120635_1_150_- FIG00000775 11 3 12 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_120640_19_657_- FIG00005103 19 6 21 LysR family transcriptional regulator YfiE DNA-binding regulatory proteins, strays 1 T2D_unique_120644_313_690_- FIG00000672 65 12 67 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_120651_1_690_+ FIG00000422 194 28 194 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_120681_1_690_+ FIG00000207 185 27 185 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_120715_1_690_- FIG00000151 26 6 28 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_120723_1_690_+ FIG00002470 46 10 48 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_120727_1_164_- FIG00003439 4 2 5 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_120727_238_690_- FIG00000260 42 8 45 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_120746_15_347_- FIG00041038 10 3 11 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_120766_1_304_+ FIG00000704 74 11 74 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_120766_327_690_+ FIG01959389 105 14 105 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_120779_327_690_- FIG00018865 23 6 24 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_120781_1_690_+ FIG00000308 46 12 47 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_120790_1_690_+ FIG00003596 48 12 50 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_120795_1_594_- FIG00019251 21 8 28 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_120854_1_690_- FIG00018457 9 4 12 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_120874_1_142_+ FIG00074916 16 3 17 Acetolactate synthase, catabolic (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_120874_144_689_+ FIG00000450 75 16 77 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_120906_1_689_+ FIG00000043 45 13 47 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_120947_477_689_- FIG00000687 40 7 41 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_unique_120966_1_214_- FIG00103661 12 3 13 Transcriptional regulator, MerR family, near polyamine transporter Polyamine Metabolism 2 T2D_unique_121009_210_689_+ FIG00079822 34 9 35 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_121048_1_689_+ FIG00001750 101 19 103 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_121087_1_689_- FIG00015519 185 27 185 type 1 fimbriae anchoring protein FimD Type 1 pili (mannose-sensitive fimbriae) 1.x T2D_unique_121104_1_689_+ FIG00000539 138 22 139 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_121146_1_688_- FIG00006463 119 18 121 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_121150_1_521_- FIG00000404 140 20 142 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_121177_1_688_+ FIG00000985 55 10 57 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_121253_1_688_+ FIG00000223 145 25 146 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_121262_1_688_+ FIG00001882 172 24 172 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_121287_426_688_- FIG00034392 18 7 19 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_121331_1_228_+ FIG00229695 43 7 43 Histidine triad (HIT) nucleotide-binding protein, similarity with At5g48545 and yeast YDL125C (HNT1) CBSS-176279.3.peg.1262 1.x T2D_unique_121352_462_688_+ FIG00000025 29 6 30 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_121354_1_688_- FIG00000080 49 13 52 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_121401_1_389_+ FIG00000146 66 12 67 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_121424_1_612_+ FIG00028461 34 7 37 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_121458_1_366_- FIG00026750 41 8 43 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_unique_121483_172_417_+ FIG00000435 52 9 52 Exodeoxyribonuclease VII small subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_121507_1_453_- FIG00007025 11 3 12 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_121515_1_687_+ FIG00000504 20 7 22 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_121527_1_218_+ FIG00020185 48 8 48 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_121527_274_687_+ FIG00006551 82 13 82 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_121533_86_687_- FIG00000289 10 7 12 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_121547_1_687_+ FIG00000241 155 25 155 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_121563_1_479_- FIG00006151 67 14 68 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_121577_49_687_+ FIG00000422 32 5 35 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_121581_244_687_- FIG00005487 80 14 81 Glutamine amidotransferase, class-II Ammonia assimilation 1 T2D_unique_121623_50_687_- FIG00000040 40 10 42 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_121639_294_687_- FIG00004074 19 5 20 Ferredoxin-type protein NapG (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_121640_503_687_+ FIG00003270 3 2 5 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_unique_121669_418_687_- FIG00000015 6 2 7 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_121685_1_153_- FIG00014596 7 2 8 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_121715_302_604_+ FIG00000402 18 5 20 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_121716_234_686_- FIG00001469 39 10 40 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_121739_1_598_- FIG00009149 67 16 69 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_121768_1_532_+ FIG00001385 9 3 10 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_121794_1_686_+ FIG00000532 48 12 50 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_121796_1_686_+ FIG00051009 143 23 143 Iron(III) dicitrate transport system permease protein FecD (TC 3.A.1.14.1) Flavohaemoglobin 1 T2D_unique_121815_1_475_- FIG00044622 6 2 9 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_121842_1_165_+ FIG00000212 12 2 14 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_121852_1_686_+ FIG00000043 92 17 93 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_121856_1_686_+ FIG00001750 169 27 169 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_121876_1_498_- FIG00000380 17 4 18 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_121967_36_685_- FIG00001616 9 3 11 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_121985_1_225_+ FIG00000111 8 3 9 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_121991_1_685_- FIG00046929 161 23 162 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_122000_1_595_+ FIG01260980 25 7 26 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_122001_27_685_+ FIG00000865 6 7 31 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_122019_1_685_- FIG00001469 49 12 51 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_122038_1_277_- FIG00031250 10 5 11 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_122045_1_685_+ FIG01260980 186 27 186 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_122061_432_685_+ FIG00006092 37 7 39 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_122069_300_685_- FIG00000520 41 8 42 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_122084_214_685_+ FIG00000185 34 8 35 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_122092_481_685_+ FIG00134889 3 2 4 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_122098_1_489_+ FIG00000242 7 3 8 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_122118_185_685_- FIG00006933 26 7 27 Alpha-1,4-N-acetylgalactosamine transferase PglH (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_122123_1_179_+ FIG00000156 36 7 36 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_122123_200_685_+ FIG00000242 76 13 77 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_122125_274_685_+ FIG00001896 6 3 9 LSU ribosomal protein L25p Ribosome LSU bacterial 9 T2D_unique_122146_285_512_- FIG00000583 11 3 13 RNA-binding protein Hfq Hfl operon 1.111 T2D_unique_122169_44_262_+ FIG00002958 4 2 5 FIG002958: hypothetical protein Hypothetical Coupled to RecF 1 T2D_unique_122185_1_685_+ FIG01292786 46 12 48 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_122206_1_226_- FIG00002541 17 5 18 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_122216_17_685_- FIG00007025 120 17 120 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_122217_62_421_+ FIG00002020 93 13 93 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_122227_435_684_- FIG00001029 27 6 30 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_122253_18_371_+ FIG01292786 80 12 80 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_122253_387_684_+ FIG00133227 64 11 64 N-acetylneuraminate lyase (EC 4.1.3.3) Sialic Acid Metabolism 1.x T2D_unique_122262_1_684_+ FIG00001469 45 10 51 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_122326_20_684_+ FIG00000350 20 7 22 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_122345_118_684_- FIG00008736 28 8 30 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_122364_115_684_- FIG00000392 93 17 94 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_122367_389_684_- FIG01260980 16 3 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_122368_196_684_+ FIG00011114 18 5 25 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_122372_141_684_+ FIG00000047 68 15 70 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_122381_428_684_+ FIG00001548 13 3 14 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_122400_258_684_- FIG00000402 18 5 19 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_122426_412_684_- FIG00002460 36 6 37 V-type ATP synthase subunit D (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_122442_1_240_- FIG00000121 4 2 6 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_122452_84_684_+ FIG00000075 155 24 155 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_122479_1_663_+ FIG00122441 5 3 10 Two-component sensor kinase SA14-24 Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_122506_338_683_+ FIG00000288 14 3 15 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_122514_210_683_+ FIG00000841 129 18 129 Glutathione reductase (EC 1.8.1.7) Glutathione: Redox cycle 1 T2D_unique_122538_1_683_- FIG00042616 69 18 117 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_122558_408_683_- FIG00017761 70 10 70 Biopolymer transport protein ExbD/TolR Ton and Tol transport systems 2 T2D_unique_122564_1_683_+ FIG00002847 13 6 16 HflK protein Hfl operon 1.111 T2D_unique_122583_1_683_- FIG00051439 181 27 181 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_122593_157_683_+ FIG00000290 51 11 53 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_122634_1_683_+ FIG00000076 133 22 134 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_122651_517_683_+ FIG00138209 6 2 7 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_122663_1_214_- FIG01955967 7 2 8 L-alanine-DL-glutamate epimerase Muconate lactonizing enzyme family 1 T2D_unique_122671_20_683_- FIG00034392 166 25 166 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_122676_1_279_+ FIG00001065 3 2 5 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_122680_134_683_+ FIG00026918 119 18 120 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_122684_1_683_- FIG00007957 33 11 37 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_122701_496_683_+ FIG00000387 36 7 37 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_122705_547_683_+ FIG00021289 4 2 5 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_122729_1_481_- FIG00038461 50 10 55 Putative deoxyribonuclease YjjV Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_122755_1_683_+ FIG00000376 56 14 57 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_122765_1_683_- FIG00001189 124 20 126 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_122770_206_682_- FIG00006691 6 3 7 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_122782_162_479_- FIG00000268 28 8 30 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_122799_1_682_+ FIG00034851 34 9 37 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_122814_343_682_+ FIG00016110 80 13 80 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_122819_1_573_- FIG00000555 31 7 33 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_122849_1_682_+ FIG00059211 19 5 20 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_122856_1_682_+ FIG00037431 17 6 19 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_122858_1_682_- FIG00000289 89 18 91 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_122880_135_682_- FIG00002793 161 22 161 S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1A Polyamine Metabolism 2 T2D_unique_122925_1_382_- FIG00067248 56 11 57 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_122943_1_442_+ FIG01260980 41 10 42 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_122952_119_565_+ FIG00000388 49 10 50 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_122955_1_682_- FIG00000391 50 10 51 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_122959_1_408_- FIG00001364 11 4 13 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Glycine and Serine Utilization 1.12 T2D_unique_122959_418_682_- FIG00001364 16 4 17 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Glycine and Serine Utilization 1.12 T2D_unique_122968_555_682_+ FIG00002914 19 3 19 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_122972_183_682_+ FIG00000578 12 6 13 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_122988_1_682_+ FIG00018369 44 11 45 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_122992_418_682_+ FIG00033206 51 9 51 Enoyl-CoA hydratase (EC 4.2.1.17) Polyhydroxybutyrate metabolism 5.6 T2D_unique_123011_1_307_+ FIG00000494 17 5 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_123024_440_682_- FIG00054459 16 5 17 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_123034_263_682_- FIG00000177 110 16 110 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_123104_1_339_- FIG00000081 28 7 29 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_123104_367_681_+ FIG00000897 18 4 20 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_123123_331_681_+ FIG00001616 92 13 92 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_123135_1_217_- FIG00000076 41 8 42 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_123148_453_681_- FIG00000117 50 9 50 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_123163_407_681_+ FIG00012067 20 5 22 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_123165_1_681_- FIG00026918 168 26 169 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_123166_458_681_+ FIG00133227 44 8 44 N-acetylneuraminate lyase (EC 4.1.3.3) Sialic Acid Metabolism 1.x T2D_unique_123202_1_237_+ FIG01260980 63 9 63 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_123208_1_681_- FIG00000139 30 7 32 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_123245_1_681_+ FIG00000711 191 27 191 Phosphoenolpyruvate carboxylase (EC 4.1.1.31) Serine-glyoxylate cycle 1 T2D_unique_123264_1_376_- FIG00045144 34 9 36 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_123273_380_681_+ FIG00000212 33 6 34 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_123299_236_681_+ FIG00000683 36 9 37 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Methionine Biosynthesis 8 T2D_unique_123359_508_680_+ FIG00006151 7 3 13 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_123398_1_680_+ FIG00000308 6 7 20 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_123419_1_581_- FIG00116638 24 11 26 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_123436_205_680_+ FIG00000770 13 5 31 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_123441_422_680_+ FIG00001401 51 8 51 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_123459_1_680_- FIG00042616 18 7 20 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_123482_1_263_+ FIG00000102 56 9 56 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_123497_1_680_+ FIG00109688 191 27 191 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_123513_463_680_+ FIG00000086 49 8 50 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_123522_1_385_- FIG00000174 100 15 100 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_unique_123522_415_680_- FIG00000198 63 10 63 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_123572_1_680_- FIG00002300 89 18 90 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_123593_1_265_- FIG00035701 67 9 67 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_123602_420_680_- FIG00000402 15 5 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_123616_1_680_- FIG00048014 3 3 5 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_123625_1_317_+ FIG00000825 22 5 23 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_123628_166_680_- FIG00000235 36 11 39 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_123681_333_679_+ FIG01260980 37 10 38 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_123704_400_679_- FIG00000395 67 10 67 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_123705_32_679_- FIG00000555 52 13 54 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_123713_1_679_+ FIG00000111 103 19 104 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_123716_361_679_+ FIG00000560 85 12 85 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_123723_1_205_- FIG00030174 6 2 7 Predicted arginine uptake transporter Arginine Biosynthesis extended 1.0 T2D_unique_123756_421_679_+ FIG00093180 13 3 14 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_123804_346_679_+ FIG00139192 11 3 12 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_123808_1_473_- FIG00067248 59 11 60 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_123817_1_676_+ FIG00009156 157 24 158 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_123822_481_679_+ FIG00846773 7 2 8 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_123840_1_327_+ FIG00000095 64 11 64 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_123841_56_256_- FIG00001550 7 2 8 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_123849_207_530_- FIG00022300 5 2 6 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_123854_1_253_+ FIG00000206 16 4 17 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_123867_1_679_- FIG01260980 29 8 30 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_123875_1_595_+ FIG00051439 49 12 51 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_123890_416_679_- FIG00001635 17 4 18 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_123893_1_357_+ FIG00000402 7 3 9 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_123894_160_679_+ FIG00000301 117 19 118 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_123921_1_678_+ FIG00000494 7 2 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_123933_1_194_- FIG00003174 4 2 5 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_123945_1_464_- FIG00136193 96 15 97 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_123982_186_678_- FIG00000015 112 19 112 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_123993_1_678_+ FIG00003881 42 9 44 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_124015_1_678_+ FIG00846773 168 26 168 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_124031_131_678_+ FIG00012547 142 20 143 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) Biotin biosynthesis 1X T2D_unique_124047_1_298_+ FIG00000166 73 11 73 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_124051_1_678_+ FIG00028476 82 13 83 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_124055_311_532_- FIG00000621 9 3 10 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_124067_1_678_+ FIG00132617 28 10 30 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_124075_385_678_- FIG00132770 11 2 12 Prephenate and/or arogenate dehydrogenase (unknown specificity) (EC 1.3.1.12)(EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_124123_1_249_- FIG00004220 20 4 21 Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5) Protein degradation 1 T2D_unique_124135_1_140_- FIG00000043 33 5 33 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_124150_1_671_+ FIG00000001 74 18 76 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_124178_1_621_- FIG00001129 6 6 10 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_unique_124191_1_626_- FIG00000118 68 15 69 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_124225_1_241_+ FIG01290653 10 3 11 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_124228_227_677_- FIG00121768 87 16 88 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_124237_1_677_+ FIG00026918 11 4 14 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_124242_1_677_- FIG01304818 37 9 39 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_124246_70_645_+ FIG00643483 142 22 142 Attachment invasion locus protein precursor Flavohaemoglobin 1 T2D_unique_124257_91_677_+ FIG00000670 14 5 15 Twin-arginine translocation protein TatB Twin-arginine translocation system 7 T2D_unique_124274_1_586_- FIG00000065 166 24 166 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_124279_1_677_- FIG01260980 75 14 77 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_124289_541_677_+ FIG00042267 15 4 16 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_124303_87_677_- FIG00031825 131 20 132 Hydrogen peroxide-inducible genes activator DNA-binding regulatory proteins, strays 1 T2D_unique_124317_1_677_- FIG00000147 18 8 19 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_124318_16_677_- FIG00000962 39 8 43 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_124337_1_677_+ FIG00002541 3 2 4 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_124353_240_677_- FIG00044622 121 17 123 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_124357_1_318_+ FIG00000194 76 12 77 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_124361_35_677_- FIG00048507 154 24 155 Catabolite control protein A HPr catabolite repression system 1 T2D_unique_124370_43_432_- FIG00031250 3 3 5 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_124395_433_677_+ FIG00001865 7 2 8 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_124396_79_677_- FIG00001548 7 5 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_124447_1_560_- FIG00009450 17 6 19 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_124448_1_436_+ FIG00000243 15 6 17 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_124455_1_243_+ FIG00129616 34 7 35 GTP-binding protein EngA Universal GTPases 2 T2D_unique_124457_218_677_- FIG00018396 40 8 42 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_124470_1_419_+ FIG00139238 22 5 23 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_124504_1_676_- FIG00000687 13 7 15 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_unique_124506_1_567_+ FIG00000356 135 20 136 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_124533_1_676_+ FIG00000372 77 15 79 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_124559_1_676_+ FIG00132839 70 14 72 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_124587_547_676_- FIG00001548 28 5 28 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_124590_104_676_- FIG00719736 42 13 44 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_124618_141_676_+ FIG00135554 38 6 41 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_124641_268_676_- FIG00018328 45 9 47 Glycosyl transferase, group 1 CBSS-258594.1.peg.3339 1 T2D_unique_124677_1_179_- FIG00026918 46 7 46 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_124689_18_676_- FIG01955782 31 7 34 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_124700_1_575_+ FIG00007941 61 12 63 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_124718_1_676_+ FIG00061313 4 4 6 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_124738_267_676_- FIG00012945 13 4 14 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_124789_348_675_+ FIG00000899 17 4 19 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_124832_537_675_+ FIG00140898 31 5 31 periplasmic fructose-binding protein component of signal transduction system LevT Fructose and Mannose Inducible PTS 2 T2D_unique_124860_1_259_- FIG01031896 69 10 69 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_124861_1_611_- FIG00000822 73 14 74 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_124887_120_449_- FIG00034392 35 8 36 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_124893_1_675_- FIG00017431 152 24 152 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_unique_124943_1_675_- FIG00000695 16 6 19 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_124947_494_675_+ FIG00000456 5 2 7 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_124967_1_675_- FIG01260980 177 24 177 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_124989_6_675_- FIG00001548 3 2 4 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_124992_1_675_+ FIG00109688 4 4 6 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_125004_1_311_+ FIG00001188 84 12 84 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_125005_1_264_+ FIG00018536 10 3 11 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_125009_1_203_+ FIG00000704 15 4 16 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_125053_1_454_- FIG01260980 14 6 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_125063_86_674_+ FIG00007957 71 15 72 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_125078_1_185_+ FIG00094401 8 2 9 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_125111_1_674_- FIG00000038 195 27 195 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_125199_210_674_+ FIG00093180 78 12 81 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_125208_57_674_- FIG01260980 179 24 179 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_125238_1_674_+ FIG01260980 32 10 34 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_125255_1_571_+ FIG00022976 135 21 135 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_125263_389_674_- FIG00000782 51 8 52 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_125279_1_507_+ FIG00055715 26 6 28 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_125280_178_423_- FIG00003495 43 7 44 Rhodanese-like domain protein Glutaredoxins 1 T2D_unique_125280_431_674_- FIG00132548 63 9 63 Thiol peroxidase, Bcp-type (EC 1.11.1.15) CBSS-316057.3.peg.3521 1 T2D_unique_125306_1_628_- FIG00000897 34 7 37 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_125351_1_673_- FIG00001548 4 2 6 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_125355_1_673_+ FIG00000709 31 7 32 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) Periplasmic disulfide interchange 1 T2D_unique_125384_41_313_+ FIG00001563 49 8 49 Preprotein translocase subunit SecG (TC 3.A.5.1.1) Murein hydrolase regulation and cell death 1.2 T2D_unique_125390_438_673_+ FIG01304601 11 4 12 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_125394_97_673_- FIG00000108 161 23 161 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_125408_1_411_+ FIG00000001 34 8 37 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_125416_1_673_+ FIG00038343 6 3 7 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_125453_32_673_+ FIG00000126 20 4 22 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_125473_1_255_+ FIG00134135 63 9 63 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_125476_1_673_+ FIG00001209 4 3 6 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_unique_125509_501_673_+ FIG00080231 32 5 32 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_125526_88_381_+ FIG00002839 17 3 18 MutS-related protein, family 1 DNA repair, bacterial MutL-MutS system 1 T2D_unique_125565_1_673_+ FIG00093180 32 12 36 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_125568_302_673_- FIG00049915 42 7 44 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_125610_1_672_- FIG00002020 35 9 36 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_125635_1_217_+ FIG00000190 41 7 42 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_125642_1_236_- FIG00000380 3 2 9 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_125652_226_672_+ FIG00007339 18 5 20 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_125687_88_672_+ FIG00000421 168 23 168 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_125738_1_672_- FIG00005727 50 10 52 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_125742_208_672_- FIG00000897 28 7 30 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_125764_502_672_- FIG00000088 5 2 6 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_125768_244_672_- FIG00000517 24 6 25 Iron-sulfur cluster-binding protein Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_125771_544_672_+ FIG00000269 30 5 30 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_125780_1_520_- FIG00000047 39 11 41 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_125791_427_672_- FIG00047509 62 9 62 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_125811_1_513_- FIG00000440 61 12 62 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_unique_125815_142_672_+ FIG00001530 87 15 88 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_125836_1_672_- FIG00000933 27 7 29 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_unique_125842_8_672_- FIG01304601 16 7 18 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_125895_1_432_- FIG00047056 31 7 34 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_125896_211_671_- FIG01304734 27 11 37 MreB-like protein (Mbl protein) Sporulation-related Hypotheticals 2.x T2D_unique_125897_1_606_- FIG00093180 21 6 23 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_125910_1_671_+ FIG00000404 79 16 80 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_125911_1_671_- FIG00000036 112 21 113 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_125920_1_671_- FIG00001469 153 22 155 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_125924_83_265_- FIG00000409 8 3 10 LSU ribosomal protein L30p (L7e) Ribosome LSU bacterial 9 T2D_unique_125953_1_671_- FIG00109688 64 14 66 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_125984_1_603_- FIG00000985 31 9 35 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_126009_1_671_+ FIG00000283 94 17 95 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_126048_1_671_+ FIG00554193 25 12 26 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_126052_1_671_+ FIG00001269 59 15 61 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_126055_405_671_- FIG00008752 72 10 73 ComF operon protein C Gram Positive Competence 3100 T2D_unique_126086_1_260_+ FIG00002130 61 10 61 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_126090_181_671_+ FIG00024851 92 16 93 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_126100_37_671_- FIG00066575 23 7 25 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_126109_1_435_- FIG00023004 8 5 9 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_126127_1_671_- FIG00000477 58 11 60 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_126149_1_624_+ FIG00451095 155 24 155 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_126205_385_671_- FIG00000241 27 7 29 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_126216_198_670_- FIG00008736 113 18 114 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_126221_1_557_- FIG00111547 26 5 29 Putative prenyltransferase, contains 1,4-dihydroxy-2-naphthoate octaprenyltransferase domain Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_126224_396_670_- FIG00093180 6 3 7 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_126226_1_670_+ FIG00140555 50 8 51 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_126240_1_670_- FIG00846773 9 6 11 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_126256_1_670_- FIG00000442 9 7 17 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_126275_26_670_- FIG00000148 162 26 162 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_126302_1_670_+ FIG00023943 184 26 184 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_126309_1_670_- FIG00034392 78 18 80 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_126314_219_670_+ FIG00042267 3 2 6 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_126316_1_194_+ FIG00017454 7 2 9 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_126336_1_670_+ FIG00000168 190 26 190 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_126353_1_670_+ FIG00054459 129 20 130 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_126355_425_670_+ FIG00554193 3 2 5 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_126362_1_670_- FIG00000467 42 9 44 Biotin synthase (EC 2.8.1.6) Biotin biosynthesis 1X T2D_unique_126369_1_670_+ FIG00132787 43 11 45 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_126373_257_670_- FIG00000383 65 12 67 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_126388_1_302_+ FIG00000101 19 4 22 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_126409_273_670_+ FIG01955932 14 2 16 Maltose/maltodextrin transport ATP-binding protein MalK (EC 3.6.3.19) Maltose and Maltodextrin Utilization 1.x T2D_unique_126430_1_670_- FIG00459778 185 26 185 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_126438_281_670_+ FIG00000226 99 15 100 GTP cyclohydrolase I (EC 3.5.4.16) type 1 Zinc regulated enzymes 1 T2D_unique_126443_1_670_+ FIG00001088 155 25 156 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_126454_284_670_- FIG00000102 55 10 56 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_126491_1_620_- FIG00001528 45 12 48 Cobalt-precorrin-3b C17-methyltransferase Cobalamin synthesis 2 T2D_unique_126504_1_618_+ FIG00000422 13 3 15 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_126533_1_126_- FIG00109897 15 3 15 TRAP-type transport system, periplasmic component, predicted N-acetylneuraminate-binding protein Sialic Acid Metabolism 1.x T2D_unique_126557_104_669_+ FIG00041382 134 21 134 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_126558_190_669_- FIG00000445 72 14 74 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_126567_230_669_+ FIG00453259 125 17 125 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_126582_1_669_- FIG00001670 26 7 27 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_126595_1_669_+ FIG00041038 165 24 166 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_126607_1_295_+ FIG00016514 24 4 25 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_126610_1_669_+ FIG00000065 175 25 176 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_126624_1_669_+ FIG00052605 8 3 10 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_126632_1_669_+ FIG00000866 3 2 5 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_126645_1_669_- FIG00096593 176 27 176 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_126649_192_669_- FIG00001168 5 5 9 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_126665_446_669_+ FIG00000422 6 2 7 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_126674_1_226_+ FIG00006128 59 8 60 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_126678_364_669_- FIG00000156 16 4 18 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_126679_263_669_- FIG00000402 104 16 104 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_126705_1_576_- FIG00453259 118 17 119 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_126711_1_500_- FIG00054694 13 4 15 Predicted rhamnose oligosaccharide ABC transport system, substrate-binding component L-rhamnose utilization 1 T2D_unique_126713_1_332_+ FIG00084105 10 4 12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_126743_155_669_+ FIG00007373 53 11 63 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_126748_122_397_- FIG01318274 60 10 60 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_126757_1_265_+ FIG00002718 18 3 19 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_126757_280_669_+ FIG00002742 7 2 9 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_126772_1_229_+ FIG00003955 18 5 20 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_126772_251_669_+ FIG00001960 43 9 45 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_126782_445_669_+ FIG00002161 5 2 6 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_unique_126798_184_669_+ FIG00001819 66 14 67 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_126815_1_530_+ FIG00000721 43 9 44 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_126833_93_668_- FIG00010194 12 3 14 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_126891_1_668_+ FIG00138018 85 18 86 Alpha-glucosidase SusB (EC 3.2.1.20) Cellulosome 1.x T2D_unique_126911_1_668_- FIG00047414 143 24 143 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_126913_1_668_- FIG00001824 7 3 9 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_126917_1_272_- FIG00001269 65 10 65 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_126923_248_668_- FIG00023369 13 5 15 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_126939_1_434_- FIG00000376 9 3 11 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_126949_88_668_+ FIG00001036 31 7 32 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_126963_120_668_- FIG00133209 17 5 18 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_126982_1_150_- FIG00001385 3 2 5 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_127025_452_668_+ FIG00050603 15 4 16 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_127042_332_668_- FIG00000069 12 6 13 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_127044_1_261_+ FIG00000771 41 7 41 Lipoprotein releasing system ATP-binding protein LolD Lipoprotein sorting system 3 T2D_unique_127084_1_668_- FIG00003086 32 9 36 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_127123_1_270_+ FIG01956048 20 6 21 Hypothetical oxidoreductase YqhD (EC 1.1.-.-) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_127132_1_358_+ FIG00000038 9 3 11 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_127199_211_630_+ FIG00001642 9 3 11 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_127215_334_667_- FIG00000387 48 10 49 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_127219_1_667_- FIG00003520 6 3 8 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_127235_268_486_- FIG00000028 30 5 31 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_127246_97_667_- FIG00000391 36 9 37 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_127257_1_667_+ FIG00000387 163 25 164 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_127264_1_146_- FIG00000538 36 5 36 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_unique_127279_1_667_- FIG00000672 51 12 53 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_127330_1_667_- FIG00000080 180 27 180 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_127371_1_667_+ FIG00003788 19 7 21 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_127384_1_142_+ FIG00001676 7 2 8 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_127390_166_667_- FIG00000208 74 14 76 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_127422_1_255_- FIG00009628 4 2 5 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_127453_10_666_- FIG00000243 29 10 36 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_127462_1_197_+ FIG00049433 4 3 6 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_127463_1_573_+ FIG00001385 23 8 24 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_127464_1_521_+ FIG00003176 19 5 21 Pyruvate:ferredoxin oxidoreductase, gamma subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_127494_1_666_+ FIG00000764 39 10 42 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_127529_1_281_+ FIG00001649 82 11 82 N-methylhydantoinase A (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_127529_308_666_+ FIG00002013 91 13 91 N-methylhydantoinase B (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_127562_1_666_+ FIG00001548 15 11 59 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_127575_1_666_- FIG00025216 6 5 10 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_127584_317_616_+ FIG00000191 29 6 30 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_127589_407_666_+ FIG00000532 22 7 24 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_127629_1_255_+ FIG00000979 5 2 7 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_unique_127629_285_666_- FIG00028059 5 4 7 ATPase component CbiO of energizing module of cobalt ECF transporter ECF class transporters 345678 T2D_unique_127657_1_666_+ FIG00018699 4 4 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_127674_79_666_- FIG00008370 155 22 155 Creatinine amidohydrolase (EC 3.5.2.10) Creatine and Creatinine Degradation 4.0 T2D_unique_127714_65_421_- FIG01260980 40 6 41 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_127729_1_406_- FIG00000494 33 8 34 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_127731_1_665_- FIG00025734 175 26 175 Predicted L-rhamnose ABC transporter, substrate-binding component L-rhamnose utilization 1 T2D_unique_127783_1_665_+ FIG00561498 194 27 194 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_127787_255_665_- FIG00132787 30 7 32 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_127820_291_665_+ FIG00005727 25 5 26 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_127824_1_665_- FIG00015338 12 5 15 D-beta-hydroxybutyrate permease Polyhydroxybutyrate metabolism 5.6 T2D_unique_127827_506_665_- FIG00000494 13 3 14 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_127861_1_665_+ FIG00000242 179 27 179 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_127862_1_665_+ FIG00000425 42 15 55 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_127864_1_665_+ FIG00020613 185 27 185 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_127901_1_665_+ FIG00001385 49 10 51 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_127915_1_665_+ FIG00000111 72 17 73 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_127936_350_550_+ FIG00140555 18 3 19 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_127938_261_665_- FIG00000146 58 9 59 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_127962_157_665_+ FIG00008907 4 5 6 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_128031_96_664_- FIG00000842 32 10 33 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_128037_1_240_- FIG00000165 46 8 47 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_128046_1_664_- FIG00000176 86 16 87 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_128054_1_278_- FIG00079521 45 7 46 TRAP dicarboxylate transporter, DctM subunit, unknown substrate 8 CBSS-49338.1.peg.459 1 T2D_unique_128057_221_664_- FIG00013366 115 17 115 ADP-heptose--lipooligosaccharide heptosyltransferase II (EC 2.4.1.-) LOS core oligosaccharide biosynthesis 1.x T2D_unique_128059_359_664_- FIG00048580 9 2 11 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_128062_1_664_+ FIG01303963 3 4 10 Ribonuclease J2 (endoribonuclease in RNA processing) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_128071_1_664_- FIG00000235 43 11 44 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_128085_109_664_- FIG00041038 17 5 20 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_128104_1_163_- FIG00001642 7 4 8 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_128128_133_540_+ FIG00000296 42 8 44 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_unique_128145_14_664_- FIG00001893 68 13 70 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_128160_1_482_- FIG01546819 9 3 10 TPP-requiring enzyme co-localized with putative O-antigen rfb gene cluster Acetoin, butanediol metabolism 5 T2D_unique_128190_1_664_+ FIG00000011 67 14 68 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_128192_1_248_- FIG00561498 10 3 13 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_128230_1_342_+ FIG00055520 87 13 87 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_128230_352_664_+ FIG00022445 81 12 81 Regulation of D-alanyl-lipoteichoic acid biosynthesis, sensor histidine kinase Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_128243_1_664_- FIG00001904 18 8 20 Outer surface protein of unknown function, cellobiose operon Beta-Glucoside Metabolism 2.bc T2D_unique_128268_1_664_- FIG00133034 6 3 8 Excinuclease ABC subunit A paralog of unknown function DNA repair, UvrABC system 1 T2D_unique_128274_1_492_- FIG00000445 30 5 33 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_128309_1_246_+ FIG00001067 37 8 38 Rubrerythrin Oxidative stress 1.2 T2D_unique_128314_1_281_- FIG00000271 14 6 15 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_unique_128314_308_664_- FIG00000263 36 7 38 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_128317_76_663_- FIG00003090 3 2 5 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_unique_128329_1_663_+ FIG00008941 117 20 118 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_128330_433_663_- FIG00020613 39 7 41 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_128346_1_645_+ FIG00000532 89 17 90 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_128369_386_663_- FIG00000477 28 5 29 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_128379_172_663_- FIG00000146 54 11 56 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_128459_149_663_+ FIG00018457 5 4 6 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_128477_184_663_- FIG00109688 58 10 59 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_128485_1_330_+ FIG00000962 54 11 55 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_128485_401_663_+ FIG01176807 19 5 21 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_128490_1_312_+ FIG00146664 89 12 89 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_128490_314_663_+ FIG00000132 76 12 76 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_128493_1_438_+ FIG00135742 12 4 14 Ribonuclease HI-related protein Ribonuclease H 1.010 T2D_unique_128507_1_558_+ FIG00000190 73 16 74 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_128530_199_663_- FIG00561498 8 2 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_128532_1_226_- FIG00000234 22 4 23 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_128550_208_663_- FIG00120441 70 11 71 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_128553_1_663_- FIG00047056 166 26 166 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_128568_146_663_+ FIG00000149 9 3 11 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_128571_1_663_- FIG00133325 20 4 25 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_128580_1_398_+ FIG00000001 11 4 12 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_128584_488_663_+ FIG00001819 21 5 22 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_128591_1_663_+ FIG00009194 7 3 9 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_128610_1_662_- FIG00011272 4 4 6 Prolyl endopeptidase (EC 3.4.21.26) EC 3.4.21.- Serine endopeptidase 1 T2D_unique_128655_1_540_+ FIG00034973 3 3 6 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_unique_128656_1_662_- FIG00000069 4 4 6 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_128657_1_662_+ FIG00019251 62 14 63 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_128679_409_662_+ FIG00060517 18 4 20 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_128680_1_662_- FIG00006887 17 4 18 ABC transporter, predicted N-acetylneuraminate-binding protein Sialic Acid Metabolism 1.x T2D_unique_128687_1_531_- FIG00035701 19 6 21 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_128689_1_662_+ FIG00000317 158 26 158 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_128726_1_662_- FIG00051439 11 4 16 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_128728_1_170_- FIG00000453 9 2 11 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_128762_115_662_+ FIG00000011 11 3 12 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_128766_1_662_- FIG00016663 104 19 105 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_128793_32_662_- FIG00018369 5 2 6 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_128801_487_662_+ FIG00133325 40 7 40 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_128823_21_353_+ FIG00060517 86 12 87 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_128823_530_662_+ FIG00000582 31 5 31 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_128833_1_512_- FIG00011622 9 3 11 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_128888_1_190_- FIG00074916 40 7 40 Acetolactate synthase, catabolic (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_128893_516_662_+ FIG00000252 32 5 32 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_128917_1_662_- FIG00000578 16 4 18 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_128945_102_380_+ FIG01260980 20 6 21 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_128949_1_661_- FIG00001548 32 10 34 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_128964_410_661_- FIG00006151 4 2 6 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_128968_203_661_+ FIG00001306 78 13 79 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_unique_128988_1_513_+ FIG00018201 58 11 60 HflC protein Hfl operon 1.111 T2D_unique_128991_1_661_+ FIG00002588 12 5 18 Formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) One-carbon metabolism by tetrahydropterines 5 T2D_unique_129009_1_661_- FIG00024930 100 17 102 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_129014_224_661_+ FIG00000001 18 7 20 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_129015_99_661_- FIG00001555 158 22 158 Cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Putative oxidase COG2907 9 T2D_unique_129029_53_661_- FIG00000070 8 4 11 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_129031_1_661_+ FIG00080231 100 20 101 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_129058_452_661_+ FIG00008273 30 5 31 N-acetylneuraminate synthase (EC 2.5.1.56) Sialic Acid Metabolism 1.x T2D_unique_129074_313_661_+ FIG00027222 24 5 26 GDP-L-fucose synthetase (EC 1.1.1.271) Capsular heptose biosynthesis 1 T2D_unique_129081_1_661_- FIG00001618 113 21 114 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_129086_1_661_- FIG00004764 58 13 60 Ammonium transporter Ammonia assimilation 1 T2D_unique_129144_1_661_- FIG00002020 72 15 73 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_129149_1_661_+ FIG00002968 3 4 5 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_129172_1_661_+ FIG00001548 29 9 31 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_129208_186_661_- FIG00006128 121 18 121 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_129210_419_661_+ FIG00719736 7 3 8 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_129213_1_661_+ FIG00000243 5 4 7 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_129261_1_660_+ FIG00001385 28 8 30 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_129265_1_252_- FIG00000157 6 3 8 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_129267_68_660_+ FIG00031392 31 7 32 Transcriptional regulator of fucose utilization, GntR family L-fucose utilization 1 T2D_unique_129288_1_457_+ FIG00006092 17 6 19 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_129307_181_660_+ FIG01260980 133 19 133 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_129321_1_258_+ FIG00000367 35 6 36 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_129331_107_660_- FIG00001932 138 21 139 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_129354_1_660_+ FIG00000614 149 23 152 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_unique_129371_1_660_+ FIG00011468 8 5 9 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_129388_112_660_+ FIG00000038 38 11 41 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_129403_1_421_- FIG00000402 98 15 98 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_129408_91_660_+ FIG00028461 17 4 20 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_129424_1_173_- FIG00003472 26 6 28 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_129446_1_660_+ FIG00041038 139 23 139 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_129474_121_660_+ FIG00000241 75 13 77 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_129497_189_660_+ FIG00018457 77 14 77 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_129502_1_306_+ FIG00049915 73 11 73 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_129510_138_660_- FIG00001094 49 12 50 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_129527_1_660_+ FIG00000132 98 19 100 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_129532_1_659_+ FIG00135546 16 6 18 Predicted rhamnogalacturonan lyase in rhamnose utilization cluster L-rhamnose utilization 1 T2D_unique_129555_280_659_- FIG00000235 7 4 9 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_129560_1_579_- FIG00022300 36 8 39 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_129589_1_659_- FIG00001547 189 26 189 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_129620_1_659_+ FIG00000128 77 15 79 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_129629_1_611_- FIG00001469 99 16 99 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_129636_1_659_- FIG00001548 39 14 41 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_129642_234_659_- FIG01304601 7 5 10 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_129646_1_659_+ FIG00001547 20 7 21 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_129647_483_659_+ FIG00000070 4 2 5 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_129669_1_344_+ FIG00034392 15 6 25 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_129675_316_659_+ FIG00000372 6 2 8 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_129706_1_659_+ FIG00016768 46 11 48 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_129720_299_659_+ FIG00001022 10 3 11 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_129766_1_659_+ FIG00024401 10 2 11 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_129800_1_538_+ FIG01303154 27 7 29 Ubiquinone/menaquinone biosynthesis methyltransferase UbiE (EC 2.1.1.-) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_129802_1_659_- FIG00010454 168 26 168 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_129812_92_577_- FIG00000151 78 13 79 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_129827_1_530_- FIG00003715 31 9 32 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_129847_1_658_- FIG00014596 3 2 5 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_129862_276_658_+ FIG00080231 61 10 62 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_129866_1_501_+ FIG00000510 26 6 29 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_129881_1_330_+ FIG00002600 13 6 14 MoxR-like ATPase in aerotolerance operon CBSS-345072.3.peg.1318 1 T2D_unique_129884_253_658_- FIG00000146 9 2 10 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_129897_1_658_+ FIG00060517 36 9 40 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_129900_1_151_+ FIG01955774 21 4 22 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_129922_1_658_- FIG00459778 19 9 20 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_129943_1_216_- FIG00004014 53 8 53 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_129954_1_658_- FIG00003381 6 2 8 L-cystine uptake protein TcyP L-Cystine Uptake and Metabolism 6.0 T2D_unique_129965_1_587_- FIG00000459 8 3 10 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_129974_504_658_- FIG00016110 7 2 9 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_129995_425_658_- FIG00004528 21 5 22 Di-/tripeptide transporter Proton-dependent Peptide Transporters 1 T2D_unique_129997_51_658_- FIG00016663 3 3 7 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_130030_1_658_+ 4 3 6 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_130035_1_658_- FIG00134889 116 19 117 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_130054_1_598_+ FIG00002110 78 13 80 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_130083_485_658_+ FIG00044478 8 3 10 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_130129_1_491_+ FIG00000738 43 10 45 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_130129_496_657_+ FIG00038456 6 2 7 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_130135_1_426_+ FIG00000194 86 13 87 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_130150_1_657_- FIG00000425 184 26 184 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_130175_195_657_- FIG00041038 4 4 6 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_130193_1_386_+ FIG00000223 91 14 92 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_130203_1_490_- FIG00000539 21 8 23 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_130266_343_588_- FIG00000329 26 4 27 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_130277_1_657_+ FIG00000397 69 14 71 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_130391_1_657_- FIG00000539 138 22 140 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_130418_161_657_- FIG00001385 26 8 28 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_130459_1_656_+ FIG00000087 16 6 17 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_130469_1_656_- FIG00012037 35 6 37 heterodisulfide reductase, iron-sulfur binding subunit, putative Anaerobic respiratory reductases 3 T2D_unique_130492_1_401_- FIG00002300 100 15 101 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_130492_414_587_- FIG00002070 43 6 43 Arabinose-proton symporter L-Arabinose utilization 1 T2D_unique_130494_1_500_+ FIG00000624 9 3 12 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_130496_423_656_- FIG00000017 12 4 13 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_130504_1_560_- FIG00002561 67 12 68 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_130508_1_375_- FIG00023946 19 5 21 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_130508_390_569_+ FIG00000645 7 3 11 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_130565_1_162_- FIG00010738 26 5 26 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_130579_1_486_+ FIG00004453 11 4 12 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_130587_1_570_- FIG00000122 54 13 58 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_130593_1_656_+ FIG00016514 41 15 88 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_130603_84_656_- FIG00000191 145 23 146 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_130635_1_513_+ FIG00070611 53 11 56 Phosphonate ABC transporter permease protein phnE1 (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_130635_516_656_+ FIG00039528 8 2 9 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) Purine conversions 4.1118100 T2D_unique_130646_233_656_+ FIG00000001 109 16 111 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_130650_1_187_+ FIG00623809 19 4 20 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_130677_405_656_+ FIG00001732 17 4 19 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_130690_1_656_+ FIG00066425 167 24 167 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_130730_236_656_- FIG00132820 7 3 11 Arogenate dehydrogenase (EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_130739_1_141_- 27 5 27 Negative regulator of genetic competence MecA Gram Positive Competence 3100 T2D_unique_130768_1_284_+ FIG00000402 15 4 16 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_130785_1_325_- FIG00002470 26 5 27 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_130790_1_655_+ FIG00000423 7 3 9 Dethiobiotin synthetase (EC 6.3.3.3) Biotin biosynthesis 1X T2D_unique_130797_1_164_- FIG00006955 37 6 37 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_130806_1_266_- FIG00000187 30 6 31 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_130808_450_655_+ FIG00459778 32 6 33 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_130824_1_655_+ FIG00000372 142 22 143 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_130825_1_529_+ FIG01280345 54 13 55 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_130838_1_655_+ FIG00000793 76 14 91 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_130857_1_597_- FIG00147632 12 4 14 Putative 3-hydroxyacyl-coa dehydrogenase Polyhydroxybutyrate metabolism 5.6 T2D_unique_130866_1_655_- FIG00000962 155 23 156 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_130871_1_655_+ FIG00000268 162 24 163 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_130924_1_655_- FIG00001065 13 7 15 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_130945_1_315_+ FIG00002049 37 7 38 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_130954_403_655_+ FIG00004099 33 7 35 Regulatory protein RecX RecA and RecX 1 T2D_unique_130983_183_655_- FIG00126843 129 19 129 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_130989_294_655_+ FIG00000352 35 9 37 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_131003_1_655_+ FIG00145793 165 25 165 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase (EC 6.3.2.7) Peptidoglycan biosynthesis--gjo 1 T2D_unique_131029_1_228_- FIG00000314 14 5 16 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_131045_1_655_+ FIG00000387 82 15 83 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_131090_289_654_- FIG00008490 42 8 46 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_131115_1_267_+ FIG00059211 11 4 12 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_131131_1_654_- FIG00000011 55 15 57 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_131149_1_140_+ FIG00561498 27 5 27 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_131158_1_654_+ FIG00001518 120 19 124 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_131207_515_654_+ FIG00000456 29 4 29 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_131225_1_326_- FIG00000695 82 12 82 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_131249_139_528_+ FIG00059881 104 15 105 Transmembrane component NikQ of energizing module of nickel ECF transporter ECF class transporters 345678 T2D_unique_131259_1_654_- FIG00004764 50 10 52 Ammonium transporter Ammonia assimilation 1 T2D_unique_131260_1_532_+ FIG00059881 50 10 53 Transmembrane component NikQ of energizing module of nickel ECF transporter ECF class transporters 345678 T2D_unique_131274_424_654_+ FIG00045144 28 6 29 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_131288_305_654_+ FIG00007339 8 3 10 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_131313_91_654_- FIG00004655 42 11 44 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_131360_1_243_+ FIG00001676 53 8 54 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_131365_1_619_- FIG00004655 168 25 168 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_131368_165_584_+ FIG00000164 111 16 111 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_unique_131377_434_654_+ FIG00000434 3 2 4 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_131387_1_185_- FIG00003460 11 3 12 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_131393_1_324_- FIG00077620 7 4 9 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_131396_1_653_- FIG00004078 7 4 10 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_131530_1_266_+ FIG00009628 20 5 21 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_131531_1_392_- FIG00000356 31 6 32 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_131552_362_653_- FIG00000312 47 7 48 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_131569_1_653_- FIG00000594 21 7 23 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_131575_11_526_- FIG00001548 23 5 24 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_131620_1_653_+ FIG00018561 36 12 38 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_131633_1_552_- FIG00139735 135 21 135 fructose sensor histidine kinase Fructose and Mannose Inducible PTS 2 T2D_unique_131639_1_280_+ FIG00000193 58 8 59 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_unique_131679_1_652_+ FIG00010600 37 10 45 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_131684_1_280_+ FIG00022300 14 3 19 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_131691_104_652_- FIG00001505 34 10 36 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_131767_1_652_- FIG00001188 16 5 19 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_131796_1_652_+ FIG00000441 174 26 174 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_131802_1_399_- FIG00000245 27 8 28 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_131818_48_652_+ FIG00000494 4 3 6 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_131888_1_652_- FIG00000672 12 9 16 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_131894_1_263_- FIG00000203 27 6 28 SSU ribosomal protein S12p (S23e) Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_131912_1_130_+ FIG00003270 8 2 9 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_unique_131956_1_652_- FIG00001088 178 26 178 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_131981_1_652_+ FIG00018396 17 6 24 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_132056_1_331_- FIG00007957 14 4 15 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_132056_333_620_+ FIG00009265 14 4 15 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) Selenocysteine metabolism 1.1 T2D_unique_132073_106_597_+ FIG00000261 26 7 28 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_132076_1_651_+ FIG01260980 185 26 185 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_132111_1_651_- FIG00001036 51 13 53 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_132113_1_651_- FIG00000365 130 22 132 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_132130_1_463_- FIG00005237 71 14 72 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_132139_1_651_+ FIG00001269 80 14 81 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_132154_361_651_- FIG00000296 72 11 72 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_unique_132170_29_370_- FIG00007256 20 6 22 FIG139598: Potential ribosomal protein CBSS-176279.3.peg.868 1.x T2D_unique_132176_1_651_- FIG00001548 105 18 107 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_132177_1_264_- FIG00005111 28 6 29 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_unique_132183_48_437_- FIG00005172 9 3 12 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_132183_451_651_- FIG00003435 37 7 37 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_132185_1_237_+ FIG00093180 69 9 69 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_132193_73_651_- FIG01278268 7 4 9 Teichoic acid biosynthesis protein Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_132220_383_646_+ FIG00000001 10 4 11 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_132223_138_651_- FIG00000185 11 4 14 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_132243_277_651_- FIG01266244 24 7 25 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_132271_1_406_+ FIG00046929 10 2 11 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_132275_1_651_- FIG00000721 13 4 15 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_132276_1_651_+ FIG00000111 69 16 71 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_132283_40_651_+ FIG00001269 7 2 9 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_132284_524_651_+ FIG00000317 7 2 7 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_132337_473_650_- FIG00000422 12 3 13 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_132367_6_407_- FIG00003881 15 5 17 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_132379_349_650_- FIG00008304 34 7 35 Aspartate 1-decarboxylase (EC 4.1.1.11) Coenzyme A Biosynthesis A.191 T2D_unique_132390_1_650_+ FIG00001188 70 16 71 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_132407_114_650_- FIG00001129 28 8 30 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_unique_132408_507_650_+ FIG00000328 7 2 8 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_132446_81_650_+ FIG01260980 33 9 35 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_132505_147_650_- FIG00001188 25 6 27 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_132509_149_650_+ FIG00034392 89 15 90 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_132513_337_650_+ FIG00034392 22 6 23 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_132516_1_650_+ FIG00047056 151 25 152 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_132518_1_650_- FIG00000422 4 2 6 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_132524_1_650_+ FIG00000080 41 12 43 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_132555_1_215_+ FIG00051439 22 6 24 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_132583_1_650_- FIG00000793 179 26 179 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_132584_1_574_+ FIG00067681 26 8 29 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_132593_1_650_+ FIG00000748 6 4 8 Leucyl/phenylalanyl-tRNA--protein transferase (EC 2.3.2.6) Protein degradation 1 T2D_unique_132602_209_650_+ FIG00000491 28 7 29 Queuosine Biosynthesis QueC ATPase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_132608_1_650_+ FIG00134889 80 15 81 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_132625_1_650_- FIG00004078 4 3 6 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_132673_1_259_- FIG00066425 33 6 34 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_132683_493_649_- FIG00000182 13 4 14 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_132713_1_649_+ FIG00138298 8 5 10 Predicted L-lactate dehydrogenase, Iron-sulfur cluster-binding subunit YkgF L-rhamnose utilization 1 T2D_unique_132715_67_649_+ FIG00029868 46 11 49 Epi-inositol hydrolase (EC 3.7.1.-) Inositol catabolism 5.x T2D_unique_132728_1_530_+ FIG01297554 69 11 70 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_132778_1_396_+ FIG00000464 37 7 40 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_132778_400_649_+ FIG00000047 32 6 34 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_132781_141_649_- FIG00001088 28 5 31 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_132793_1_441_+ FIG00000261 6 3 8 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_132803_335_649_+ FIG00001469 12 4 14 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_132825_1_649_+ FIG00002470 37 10 38 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_132849_1_649_- FIG00000877 41 7 43 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_132869_4_183_- FIG00008879 46 7 46 Heme transporter IsdDEF, lipoprotein IsdE Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_132869_220_649_- FIG00008879 80 13 80 Heme transporter IsdDEF, lipoprotein IsdE Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_132881_193_649_+ FIG00010508 39 9 42 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_132888_311_649_- FIG00036772 10 4 12 Arabinan endo-1,5-alpha-L-arabinosidase (EC 3.2.1.99) L-Arabinose utilization 1 T2D_unique_132901_1_649_+ FIG00066643 8 5 16 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_132906_521_649_+ FIG00140555 30 5 30 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_132914_1_128_- FIG00067681 28 4 28 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_132914_148_649_- FIG00000151 129 19 130 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_132937_8_649_- FIG00000372 89 20 90 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_132956_327_649_+ FIG00000028 42 7 44 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_132987_1_648_- FIG00007960 34 11 37 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_133062_1_648_+ FIG00018699 7 4 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_133069_1_426_- FIG00000659 53 11 54 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_133069_428_648_- FIG00002486 7 2 8 L-fuculose phosphate aldolase (EC 4.1.2.17) L-fucose utilization 1 T2D_unique_133091_390_648_- FIG00001402 70 10 70 Helicase loader DnaI DNA-replication 4 T2D_unique_133134_338_648_+ FIG00093180 55 8 56 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_133135_1_648_+ FIG01304818 57 13 59 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_133161_1_198_- FIG00000102 44 7 44 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_133164_1_312_- FIG00000076 9 3 10 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_133164_454_648_- FIG00000391 26 6 27 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_133177_1_493_- FIG00007941 37 10 39 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_133195_1_648_+ FIG00009450 3 3 12 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_133199_1_648_- FIG00022899 52 13 53 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_133269_1_648_- FIG00000520 175 25 175 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_133276_1_303_+ FIG00000277 21 4 22 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_133285_1_133_- FIG00003535 3 2 4 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_133305_1_556_+ FIG00133196 24 6 25 L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_133320_1_615_+ FIG00000070 142 20 142 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_133324_42_647_+ FIG00001166 93 15 95 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_133334_1_446_- FIG00000317 5 3 6 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_133335_293_647_+ FIG00077620 25 6 26 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_133349_1_317_- FIG00017431 68 11 70 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_unique_133424_59_647_- FIG00009450 6 5 8 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_133429_1_647_+ FIG00000439 156 24 157 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_133433_479_647_+ FIG00001618 10 2 12 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_133445_1_470_+ FIG00000441 62 12 64 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_133515_484_647_- FIG00000173 39 6 39 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_133552_1_647_+ FIG00034851 7 3 9 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_133591_229_647_- FIG00146581 10 2 12 Beta-galactosidase 3 Galactosylceramide and Sulfatide metabolism 7 T2D_unique_133624_1_459_- FIG00007586 16 3 17 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_133638_72_646_- FIG00000976 37 10 39 Transcription elongation factor GreB Transcription factors bacterial 1 T2D_unique_133642_1_646_- FIG01292786 34 7 37 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_133662_1_646_- FIG00035175 182 25 182 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_133724_434_595_- FIG00132787 5 2 6 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_133750_1_363_+ FIG00003955 17 5 18 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_133750_494_646_+ FIG00001618 5 2 6 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_133754_460_646_+ FIG01280345 37 6 37 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_133757_1_646_+ FIG00453259 144 23 144 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_133812_1_646_- FIG00000116 30 9 32 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_133815_141_646_- FIG00711303 109 17 110 Guanine-hypoxanthine permease Purine Utilization 1 T2D_unique_133834_1_646_- FIG01304636 168 25 168 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_133842_350_646_- FIG00000126 10 4 11 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_133852_318_646_- FIG00023004 19 4 27 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_133856_1_646_+ FIG00034293 50 12 51 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_133865_1_642_+ FIG00138209 12 4 13 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_133876_406_646_+ FIG00000402 34 7 35 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_133908_1_490_- FIG00002020 57 10 58 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_133920_1_579_+ FIG00000235 75 14 77 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_133923_1_645_+ FIG00000477 62 14 64 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_133937_1_645_- FIG00000122 169 26 169 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_134038_1_645_- FIG00132617 15 7 17 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_134076_1_342_- FIG00000387 3 6 36 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_134080_124_645_- FIG00009038 5 3 6 D,D-heptose 7-phosphate kinase Capsular heptose biosynthesis 1 T2D_unique_134094_1_302_- FIG00001106 20 5 21 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_134114_1_221_+ FIG00011115 15 3 16 PTS system, cellobiose-specific IIA component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_134122_1_645_- FIG00139150 173 25 173 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit B p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_134124_459_645_+ FIG00008736 7 2 9 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_134158_1_645_- FIG00000114 80 14 82 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_134172_432_645_+ FIG00000402 24 4 26 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_134177_355_645_- FIG00132666 7 2 8 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_134189_1_264_+ FIG00034392 39 8 40 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_134212_1_492_- FIG00005237 6 5 8 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_134239_1_275_- FIG00003272 21 3 21 Phage tail assembly protein I Phage tail proteins 2 4 T2D_unique_134250_1_502_+ FIG00000721 67 14 68 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_134277_1_468_+ FIG00000380 4 3 8 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_134277_486_644_+ FIG00022300 3 2 4 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_134322_1_426_+ FIG00006945 26 6 27 Anaerobic sulfite reductase subunit B Anaerobic respiratory reductases 3 T2D_unique_134322_438_644_+ FIG00009014 25 5 26 Anaerobic sulfite reductase subunit C (EC 1.8.1.-) Anaerobic respiratory reductases 3 T2D_unique_134324_1_156_+ FIG01306479 7 3 8 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_134335_41_644_- FIG00001173 11 6 13 Nitrate/nitrite response regulator protein Nitrate and nitrite ammonification 1 T2D_unique_134407_1_644_+ FIG00023943 179 26 179 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_134410_1_354_+ FIG00000101 39 6 41 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_134411_178_644_+ FIG00038611 21 7 27 Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_unique_134417_1_644_+ FIG00001865 47 9 49 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_134422_213_644_+ FIG00001980 10 3 11 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_134442_285_644_- FIG00000709 88 13 89 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) Periplasmic disulfide interchange 1 T2D_unique_134462_1_644_+ FIG00126843 22 6 23 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_134470_1_644_+ FIG00002020 14 6 16 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_134494_428_644_+ FIG00001269 16 4 17 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_134548_1_643_- FIG00001643 47 9 49 Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_134555_114_643_+ FIG00000387 152 21 152 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_134584_1_521_- FIG01961250 132 19 133 Putative N-acetylgalactosaminyl-diphosphoundecaprenol glucuronosyltransferase Teichuronic acid biosynthesis 9 T2D_unique_134631_200_448_- FIG00083946 41 7 42 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_134640_194_643_- FIG00048014 57 10 58 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_134660_1_643_- FIG00075702 101 19 105 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_134671_1_643_+ FIG00002020 19 6 21 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_134714_1_643_- FIG00000146 159 25 159 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_134716_1_643_- FIG00051439 35 9 37 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_134727_407_643_+ FIG00846773 9 3 11 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_134738_1_461_- FIG00000522 71 14 72 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_134739_1_254_- FIG00006691 64 9 64 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_134739_269_643_- FIG01954097 17 5 20 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_134752_1_643_+ FIG00005727 22 5 23 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_134753_1_557_- FIG00135025 12 7 14 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_134774_1_643_- FIG00024999 106 20 106 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Alkanesulfonate assimilation 9.? T2D_unique_134802_1_303_+ FIG00000234 29 6 30 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_134806_1_507_+ FIG00000348 100 15 101 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_unique_134832_134_643_+ FIG00001561 14 3 15 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_134851_276_642_+ FIG00000408 18 6 20 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_134875_1_642_- FIG00138004 90 19 92 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_134880_85_642_+ FIG00011468 47 11 48 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_134904_1_642_- FIG00000304 33 6 36 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_134950_1_642_- FIG00000793 5 2 7 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_134998_1_642_+ FIG00085033 52 11 54 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_135008_1_286_+ FIG00000206 4 4 6 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_135013_1_642_+ FIG00001882 139 21 139 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_135014_139_642_- FIG00021644 44 10 46 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_135021_1_642_+ FIG00001562 155 24 156 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_unique_135040_1_642_+ FIG00000088 17 6 22 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_135050_1_225_- FIG00475203 18 6 19 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_135060_177_642_- FIG00001106 59 11 60 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_135090_1_321_+ FIG00138960 78 12 78 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_unique_135090_410_642_+ FIG00023143 43 8 44 Autolysis response regulater LytR Murein hydrolase regulation and cell death 1.2 T2D_unique_135104_1_493_+ FIG00001548 19 7 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_135111_473_642_+ FIG00076542 37 6 37 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_135130_1_510_- FIG00229366 84 16 84 Nitrate ABC transporter, ATP-binding protein Nitrate and nitrite ammonification 1 T2D_unique_135154_1_642_+ FIG00095112 42 10 43 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) DNA-replication 4 T2D_unique_135157_439_642_- FIG00000539 19 5 20 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_135163_1_142_- FIG00000376 4 2 5 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_135203_370_641_+ FIG00002541 65 11 65 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_135236_1_641_- FIG00000422 16 5 17 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_135311_234_641_- FIG00008556 68 12 69 L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_135347_305_641_+ FIG00002716 4 2 6 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_135410_1_641_- FIG01260980 12 5 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_135411_1_641_- FIG00009229 10 2 13 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_135415_422_641_+ FIG00001449 38 6 39 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_unique_135458_1_641_+ FIG00000382 78 11 79 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_135488_316_641_- FIG00003751 18 5 19 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_135497_453_641_+ FIG00001269 30 6 31 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_135508_1_469_- FIG00000402 108 18 108 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_135514_1_641_+ FIG00013626 69 15 70 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_135532_1_640_+ FIG00000578 5 2 7 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_135542_300_640_+ FIG00554193 90 14 90 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_135552_1_576_+ FIG00075702 123 20 124 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_135556_179_640_- FIG00000333 109 18 109 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_135580_463_640_- FIG00000219 17 5 18 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_135587_1_640_- FIG00002110 74 12 75 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_135688_323_640_- FIG00000075 11 3 12 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_135715_1_371_- FIG00561498 20 5 22 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_135723_1_295_- FIG00000056 7 2 9 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_135729_1_523_+ FIG00000402 34 9 36 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_135755_1_520_- FIG00093180 5 3 7 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_135765_1_423_+ FIG00146581 7 3 8 Beta-galactosidase 3 Galactosylceramide and Sulfatide metabolism 7 T2D_unique_135774_1_640_- FIG00001635 95 20 96 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_135800_466_640_+ FIG00138585 31 6 31 Bacterial proteasome-activating AAA-ATPase (PAN) Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_unique_135831_1_640_- FIG00059426 42 10 44 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_135848_1_130_+ FIG01290653 10 2 11 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_135857_1_366_- FIG00001550 67 11 68 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_135865_440_640_- FIG00000710 31 6 32 Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_135872_173_639_- FIG00554193 19 6 21 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_135892_1_639_+ FIG00000560 166 24 167 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_135930_280_639_+ FIG00001618 35 7 35 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_135944_250_639_+ FIG00003460 9 4 11 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_135973_1_197_+ FIG01318274 7 3 8 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_136042_1_242_- FIG00009156 4 3 5 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_136057_1_330_+ FIG00000017 18 4 19 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_136065_67_639_- FIG00001548 104 19 105 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_136070_1_639_+ FIG00134368 38 11 40 Cytosine deaminase (EC 3.5.4.1) Creatine and Creatinine Degradation 4.0 T2D_unique_136072_1_603_+ FIG00022300 10 4 12 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_136083_1_639_- FIG00011114 104 20 105 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_136092_1_475_- FIG00000372 36 7 37 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_136124_191_639_- FIG00000985 117 18 117 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_136146_73_639_- FIG00036983 47 12 49 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_136222_1_518_- FIG00017186 12 4 15 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK Dihydroxyacetone kinases 3 T2D_unique_136223_1_222_+ FIG00031250 54 8 54 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_136223_308_638_+ FIG00000328 87 13 87 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_136243_1_515_+ FIG00006997 70 11 75 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_136278_1_638_+ FIG00059211 13 4 14 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_136309_1_548_+ FIG00003788 42 8 44 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_136312_1_638_+ FIG00018699 43 11 45 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_136316_1_492_+ FIG00006128 5 3 8 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_136322_450_638_+ FIG00012498 26 5 27 Uracil-DNA glycosylase family protein, clostridial type Uracil-DNA glycosylase 1 T2D_unique_136348_1_638_- FIG01260980 15 6 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_136354_210_404_+ FIG00001676 46 7 46 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_136360_162_638_+ FIG00000267 124 18 124 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_136367_1_259_- FIG00000103 11 4 14 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_136376_1_507_+ FIG00000446 75 14 77 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_136388_1_638_+ FIG00005283 72 15 73 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_136415_1_401_- FIG00004229 8 3 10 Heptaprenyl diphosphate synthase component I (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_136433_171_638_- FIG00008591 61 11 66 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_136441_1_638_+ FIG00007957 6 2 7 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_136444_1_638_+ FIG00059426 51 12 52 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_136512_49_534_- FIG00099318 3 4 8 RNA polymerase sigma factor SigV Transcription initiation, bacterial sigma factors 1 T2D_unique_136532_75_269_+ FIG00084255 3 2 5 Stage III sporulation protein AC Sporulation Cluster III A 1.x T2D_unique_136551_219_637_+ FIG00134342 50 9 51 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_136552_1_476_+ FIG00000402 57 12 58 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_136552_493_637_+ FIG00003090 3 2 4 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_unique_136597_1_327_+ FIG00000111 64 11 65 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_136605_1_637_+ FIG00000080 152 23 153 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_136623_1_256_+ FIG00051439 19 5 20 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_136638_1_128_- FIG00003073 15 3 16 Starvation lipoprotein Slp paralog Carbon Starvation 1.21 T2D_unique_136648_1_637_+ FIG00000352 45 8 48 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_136688_1_637_+ FIG00046929 167 25 167 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_136713_1_637_+ FIG00000422 69 14 72 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_136742_1_637_- FIG00007079 9 4 14 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_136751_77_637_- FIG00509773 8 3 10 Inner membrane thiol:disulfide oxidoreductase, DsbB-like Biogenesis of c-type cytochromes 1.1 T2D_unique_136782_1_191_+ FIG00016566 13 3 14 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_136803_171_637_- FIG00001735 68 12 75 Salicylate hydroxylase (EC 1.14.13.1) Salicylate ester degradation 2 T2D_unique_136808_1_215_- FIG00000112 52 8 52 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_136811_1_386_- FIG00000290 9 4 10 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_136818_1_637_- FIG00000985 84 15 85 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_136853_1_523_- FIG00007694 22 5 24 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_136888_1_636_+ FIG00001687 59 14 61 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_136927_1_533_+ FIG00004037 18 6 20 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_136956_1_536_- FIG00000391 13 6 16 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_137017_394_636_- FIG00000356 29 5 32 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_137041_230_636_- FIG00000149 18 4 20 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_137062_1_636_- FIG00000476 163 25 163 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_137063_1_595_+ FIG01176807 11 4 13 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_137114_1_636_+ FIG01260980 8 4 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_137128_1_636_- FIG01007502 6 3 7 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_137135_486_636_- FIG00007157 37 5 37 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_137152_1_636_- FIG00001548 10 3 12 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_137187_259_636_+ FIG00000464 38 9 39 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_137223_1_372_+ FIG00006128 103 15 103 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_137243_1_635_- FIG00000504 103 17 104 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_137252_1_412_- FIG00002239 82 15 82 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_137252_441_635_- FIG00002130 36 6 36 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_137294_258_635_+ FIG00028694 27 7 30 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_137310_1_567_- FIG01473072 152 22 152 Predicted glycerol-1-phosphate dehydrogenase, arabinose operon L-Arabinose utilization 1 T2D_unique_137339_1_635_+ FIG00019989 11 2 13 Ammonium transporter family Ammonia assimilation 1 T2D_unique_137343_178_635_+ FIG00035175 12 2 13 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_137369_1_635_- FIG00059211 130 21 131 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_137398_1_585_+ FIG00132839 82 12 83 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_137402_1_493_+ FIG00001469 15 5 16 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_137406_1_635_+ FIG00001750 70 16 71 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_137422_297_635_- FIG01318274 9 5 11 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_137430_1_635_+ FIG00028476 30 7 32 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_137433_49_312_+ FIG00000143 46 8 47 Translation initiation factor 1 Translation initiation factors bacterial 1.111 T2D_unique_137470_186_635_+ FIG00008370 28 7 30 Creatinine amidohydrolase (EC 3.5.2.10) Creatine and Creatinine Degradation 4.0 T2D_unique_137488_1_486_+ FIG00000001 28 8 32 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_137507_1_635_- FIG01260980 17 4 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_137518_1_635_- FIG00000121 55 10 57 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_137520_94_435_+ FIG00019652 8 3 10 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_137524_1_335_+ FIG00000477 21 5 25 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_137541_1_635_+ FIG01260980 83 17 85 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_137582_1_159_+ FIG00000103 15 5 16 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_137582_494_634_+ FIG00023369 19 4 20 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_137583_1_307_- FIG00000411 4 2 5 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_137622_1_634_+ FIG00085740 15 7 17 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_137624_1_634_- FIG01260980 176 26 176 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_137627_1_522_+ FIG00000111 38 11 39 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_137640_21_634_+ FIG00000025 142 21 142 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_137667_1_495_- FIG00018699 4 2 5 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_137748_1_134_- FIG00000113 20 3 20 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_137762_1_231_+ FIG00001106 27 5 28 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_137763_447_634_+ FIG00022976 9 4 10 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_137788_401_634_- FIG01255877 35 7 35 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_137816_1_188_+ FIG00007059 9 2 11 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_137832_1_382_- FIG00132617 9 4 11 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_137858_1_634_+ FIG00000452 14 4 16 Chemotaxis protein methyltransferase CheR (EC 2.1.1.80) Bacterial Chemotaxis 9 T2D_unique_137889_48_634_- FIG00016286 12 4 14 Ribosyl nicotinamide transporter, PnuC-like Cobalt-zinc-cadmium resistance 1.26 T2D_unique_137902_158_634_- FIG00000402 58 9 60 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_137926_1_477_- FIG00000982 92 16 93 Phosphatidylglycerophosphatase A (EC 3.1.3.27) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_137933_1_633_+ FIG00000001 137 21 138 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_137965_98_633_- FIG00001548 9 3 11 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_137970_150_539_- FIG00001298 4 2 5 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_137971_1_633_- FIG00000594 86 17 88 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_137979_34_324_- FIG00002958 5 2 7 FIG002958: hypothetical protein Hypothetical Coupled to RecF 1 T2D_unique_138010_1_267_+ FIG00000185 25 6 26 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_138011_386_633_- FIG00003086 9 3 10 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_138019_1_633_- FIG00000101 164 23 164 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_138024_191_633_- FIG00008736 106 17 108 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_138036_1_633_- FIG00561498 158 23 158 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_138050_44_633_- FIG00000710 90 17 92 Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_138052_1_318_+ FIG00002110 51 7 52 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_138060_24_633_- FIG00132666 116 19 116 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_138065_335_633_- FIG00009682 8 2 9 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_138084_1_633_+ FIG00004518 32 6 35 tRNA nucleotidyltransferase, A-adding (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_138109_1_242_- FIG00003495 57 9 57 Rhodanese-like domain protein Glutaredoxins 1 T2D_unique_138109_285_633_- FIG00001065 74 13 74 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_138129_1_633_- FIG00007984 8 4 10 Heme transporter IsdDEF, permease component IsdF Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_138136_1_600_- FIG00006032 59 13 61 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_138142_1_330_+ FIG00003715 19 4 20 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_138150_39_633_+ FIG01266244 104 18 105 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_138168_150_633_+ FIG00001067 89 15 89 Rubrerythrin Oxidative stress 1.2 T2D_unique_138186_1_387_+ FIG00615494 27 5 29 DNA-binding protein HU DNA structural proteins, bacterial 1.1100 T2D_unique_138191_1_633_- FIG00006128 4 2 5 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_138193_1_359_+ FIG00007960 5 3 6 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_138300_102_632_- FIG00001328 47 10 50 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_unique_138319_1_536_- FIG00000087 11 3 13 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_138330_1_632_+ FIG00080231 60 11 61 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_138349_1_606_+ FIG00002463 64 14 65 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_138373_120_632_+ FIG00002332 46 10 73 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_unique_138378_1_632_- FIG00018865 113 20 113 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_138388_1_630_+ FIG00010508 15 4 17 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_138400_1_267_+ FIG01297554 29 5 30 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_138420_1_632_- FIG00003086 38 12 40 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_138422_254_632_+ FIG00001469 93 14 93 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_138434_1_613_+ FIG00001548 35 8 37 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_138437_1_632_+ FIG00000118 115 20 116 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_138440_1_632_+ FIG00000377 50 11 52 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_138443_1_354_+ FIG00000085 7 2 9 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_138463_142_632_- FIG00003378 32 8 33 [NiFe] hydrogenase metallocenter assembly protein HypE NiFe hydrogenase maturation 1 T2D_unique_138467_1_632_+ FIG00001732 11 3 12 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_138477_1_632_- FIG00229386 41 8 45 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_138494_1_592_- FIG00007694 154 23 154 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_138503_387_632_+ FIG00000710 60 9 60 Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_138513_1_632_- FIG00000402 83 17 84 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_138556_445_632_+ FIG00000453 33 6 33 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_138564_1_632_- FIG00005172 10 3 11 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_138566_1_632_- FIG00000793 35 8 37 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_138574_1_531_+ FIG00000402 10 5 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_138578_120_632_+ FIG00009149 79 13 80 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_138600_1_632_+ FIG00000168 156 23 157 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_138640_1_631_+ FIG00041038 138 21 138 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_138646_1_631_- FIG00007059 44 10 46 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_138658_1_631_+ FIG00001548 174 25 174 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_138669_158_631_- FIG00080955 3 2 5 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_138686_214_631_+ FIG00001129 10 4 11 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_unique_138704_225_631_+ FIG00000098 9 3 11 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_138709_1_631_- FIG00001548 68 11 69 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_138722_468_631_- FIG00002049 13 5 14 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_138728_50_631_+ FIG00035175 93 18 95 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_138732_1_313_- FIG00000188 4 2 6 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_138746_30_512_+ FIG00016514 135 18 135 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_138752_227_631_- FIG00003788 26 6 27 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_138756_328_631_+ FIG00002914 3 2 5 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_138775_285_631_+ FIG00002289 14 5 16 Soluble lytic murein transglycosylase precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_138835_1_631_+ FIG00011468 3 2 5 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_138845_423_631_+ FIG00013638 39 7 39 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_138864_1_157_+ FIG00000013 7 2 9 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_138893_1_282_+ FIG00000717 63 9 64 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_138926_197_631_- FIG00000402 107 16 107 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_138933_1_631_- FIG00001548 40 11 42 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_138994_408_630_+ FIG00146664 35 7 36 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_139048_1_214_- FIG00004058 51 8 51 Aminopeptidase Y (Arg, Lys, Leu preference) (EC 3.4.11.15) EC 3.4.11.- Aminopeptidases 1 T2D_unique_139056_1_417_+ FIG00000145 19 5 20 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_139063_434_630_- FIG00000404 14 4 15 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_139069_95_630_+ FIG00016286 138 20 139 Ribosyl nicotinamide transporter, PnuC-like Cobalt-zinc-cadmium resistance 1.26 T2D_unique_139072_1_630_+ FIG00019251 48 10 50 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_139089_1_630_+ FIG01955774 5 2 7 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_139107_257_630_+ FIG00000365 78 14 78 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_139120_1_630_- FIG01260980 36 8 38 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_139133_1_377_+ FIG00000001 3 2 4 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_139155_1_630_- FIG00000114 55 12 56 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_139208_180_630_- FIG00002470 22 5 24 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_139244_1_630_+ FIG00016514 18 7 19 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_139273_1_630_+ FIG00133144 23 8 25 Muconate cycloisomerase (EC 5.5.1.1) Muconate lactonizing enzyme family 1 T2D_unique_139277_1_630_+ FIG00038343 4 4 6 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_139283_1_630_+ FIG00561498 11 4 14 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_139302_135_560_+ FIG01955919 24 5 25 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_139306_1_630_+ FIG00000494 60 12 62 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_139310_1_629_+ FIG00000095 19 10 38 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_139322_1_629_+ FIG00561498 38 10 40 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_139333_1_629_+ FIG00135993 32 8 34 Hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) Isoprenoid Biosynthesis 2.x T2D_unique_139371_1_199_+ FIG00004100 29 5 29 Cold shock protein CspA Cold shock, CspA family of proteins 1 T2D_unique_139371_235_629_- FIG00003535 106 16 107 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_139395_436_629_+ FIG00023946 52 7 52 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_139402_1_629_- FIG00093180 14 4 16 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_139421_121_510_- FIG00001298 4 3 5 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_139427_1_629_+ FIG00109688 42 8 47 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_139453_1_629_- FIG00025216 54 13 56 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_139472_1_454_+ FIG00001067 107 17 107 Rubrerythrin Oxidative stress 1.2 T2D_unique_139496_1_502_+ FIG00026006 88 14 89 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_139514_385_629_+ FIG00002130 13 3 14 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_139523_368_629_- FIG00001824 51 8 51 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_139531_79_629_+ FIG00000372 57 12 58 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_139540_1_592_+ FIG01260980 163 23 164 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_139575_1_321_+ FIG01260980 8 6 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_139590_356_629_+ FIG00047509 63 10 63 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_139609_1_629_- FIG00000414 44 9 46 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_139614_1_517_- FIG00010454 120 20 120 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_139633_1_149_+ FIG00004334 20 3 21 CRISPR-associated protein Cas2 CRISPRs 1 T2D_unique_139673_1_629_+ FIG00000456 36 12 37 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_139697_1_265_- FIG00000190 66 10 66 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_139697_269_628_- FIG00000557 80 14 80 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_139708_1_628_- FIG00501923 6 5 12 N-Acetyl-D-glucosamine ABC transport system, permease protein 2 Chitin and N-acetylglucosamine utilization 2 T2D_unique_139715_1_204_- FIG00000402 17 5 18 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_139721_1_628_+ FIG00000087 23 9 24 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_139722_1_628_- FIG00623809 19 7 20 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_139738_1_628_+ FIG00006151 82 17 84 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_139742_1_205_- FIG00048014 31 6 32 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_139759_196_501_+ FIG00000163 4 3 5 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_139773_67_628_- FIG00002541 13 4 15 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_139788_1_628_+ FIG00000088 91 16 92 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_139796_311_628_+ FIG01260980 31 8 33 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_139800_1_628_- FIG00002273 21 7 23 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_139829_1_628_+ FIG00000680 182 25 182 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_139830_147_628_+ FIG00001406 121 18 121 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_139878_1_580_- FIG00000933 89 17 90 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_unique_139894_354_628_+ FIG00016514 9 3 10 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_139897_1_628_+ FIG00005727 58 12 60 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_139939_1_628_- FIG00000381 40 14 42 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_unique_139962_1_242_- FIG00017615 57 9 57 Universal stress protein family Universal stress protein family 1 T2D_unique_139963_1_270_+ FIG00000368 19 4 20 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_139963_302_628_+ FIG00007960 19 5 21 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_139979_334_628_+ FIG00000269 23 5 24 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_139989_1_628_+ FIG00001548 60 12 61 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_139996_1_464_+ FIG00108342 8 3 10 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_140005_69_628_- FIG00000089 102 18 103 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_140008_276_628_- FIG00000122 89 13 89 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_140025_350_627_+ FIG00003460 30 6 32 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_140039_1_359_+ FIG00035175 83 12 84 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_140072_1_329_- FIG00016768 84 13 84 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_140109_353_627_+ FIG00083946 49 8 49 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_140120_1_549_- FIG00001882 103 16 104 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_140121_1_420_- FIG00117785 82 12 84 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_unique_140129_277_627_+ FIG00000122 44 9 46 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_140179_1_627_- FIG00000402 38 10 40 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_140187_1_627_+ FIG00011468 26 5 28 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_140239_495_627_+ FIG00000089 7 3 8 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_140250_1_627_+ FIG00000333 141 24 141 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_140257_1_627_- FIG00561498 127 22 128 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_140258_1_627_+ FIG00047414 29 9 30 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_140282_321_627_- FIG00001076 25 7 26 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_140298_1_577_+ FIG00000494 27 7 28 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_140303_1_173_+ FIG00000317 17 3 18 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_140355_1_455_- FIG00031969 47 10 48 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_140364_1_128_- FIG00001642 33 5 33 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_140369_385_627_+ FIG00000036 21 5 22 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_140372_1_173_+ FIG00023943 9 3 10 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_140375_1_627_+ FIG00055520 19 5 21 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_140385_1_332_- FIG00133569 73 12 75 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_140385_400_626_- FIG00019652 51 8 53 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_140408_264_626_- FIG00001524 14 3 16 Kynurenine formamidase, bacterial (EC 3.5.1.9) Benzoate degradation 3 T2D_unique_140429_1_626_- FIG00044622 115 18 128 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_140437_1_626_+ FIG00129616 23 4 25 GTP-binding protein EngA Universal GTPases 2 T2D_unique_140443_1_244_- FIG00092279 54 9 54 Xylose-responsive transcription regulator, ROK family Xylose utilization 1 T2D_unique_140453_448_626_- FIG00000552 10 2 11 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_140482_139_626_+ FIG00006151 37 11 38 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_140506_1_257_+ FIG00000350 7 3 9 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_140513_1_331_- FIG00000173 59 11 61 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_140513_345_626_- FIG00001054 65 10 65 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_140519_165_626_+ FIG00000304 59 12 60 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_140555_441_626_+ FIG00003270 45 7 45 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_unique_140566_16_626_- FIG00000102 67 17 68 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_140567_1_626_+ FIG00000139 137 22 138 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_140584_1_392_+ FIG00000084 102 15 102 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_140615_1_626_- FIG00001020 168 25 169 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_140625_229_626_+ FIG00028694 4 3 7 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_140632_472_626_- FIG00003174 27 5 27 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_140634_1_626_+ FIG00026137 17 4 19 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_140639_1_626_- FIG00146664 91 14 92 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_140640_1_626_- FIG00005022 48 14 49 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_140645_1_626_- FIG00133209 9 3 11 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_140663_346_626_+ FIG00014000 12 3 13 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_140679_366_626_- FIG00035893 24 6 25 Nickel ABC transporter, periplasmic nickel-binding protein NikA (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_140682_32_238_+ FIG00003580 16 3 18 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_140708_164_626_+ FIG00000208 20 6 23 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_140743_8_493_+ FIG00132839 37 9 50 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_140750_1_626_+ FIG00001818 23 5 25 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_140755_327_626_- FIG00000088 38 6 40 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_140794_1_484_+ FIG00002110 30 8 33 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_140804_99_625_+ FIG00628860 24 6 25 Hypothetical protein Cj1505c Selenocysteine metabolism 1.1 T2D_unique_140828_324_625_+ FIG00000866 19 5 21 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_140840_389_625_+ FIG00066643 12 3 13 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_140860_1_625_+ FIG00008230 8 4 10 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_140862_1_625_- FIG01260980 15 6 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_140866_1_625_+ FIG00000825 44 12 46 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_140881_1_344_+ FIG00122145 3 2 4 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_140899_1_295_- FIG00000367 67 10 67 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_140913_196_625_- FIG00000130 51 10 53 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_140919_1_625_+ FIG00001469 46 10 47 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_140951_1_625_- FIG00058830 32 7 34 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_140953_1_625_- FIG00000860 95 16 96 O-succinylbenzoic acid--CoA ligase (EC 6.2.1.26) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_140970_1_437_+ FIG00000343 52 9 53 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_140978_161_625_+ FIG00031723 29 6 32 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_unique_140996_1_142_+ FIG00001750 3 2 5 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_141006_1_171_+ FIG00000659 15 4 16 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_141063_1_367_- FIG00000672 32 7 35 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_141077_1_625_+ FIG00002354 47 13 51 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_141107_236_624_- FIG00598409 76 13 77 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_141117_132_524_- FIG00000358 20 5 22 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_141124_1_624_+ FIG00041382 10 3 11 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_141138_1_426_- FIG00004655 7 4 9 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_141160_1_289_- FIG00001750 30 6 32 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_141191_374_624_- FIG00138258 34 8 35 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_141199_1_363_- FIG00000402 12 3 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_141229_2_624_- FIG00000421 16 6 17 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_141234_178_624_+ FIG00038920 9 4 10 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_141238_5_624_- FIG00000897 31 7 34 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_141262_1_624_- FIG00002020 82 15 83 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_141269_348_624_+ FIG00001469 9 2 11 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_141276_1_262_+ 8 3 9 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_141287_1_624_+ FIG00038343 18 4 21 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_141299_205_624_- FIG00003506 11 4 13 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_141357_167_624_+ FIG00022300 41 10 42 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_141388_1_624_- FIG00000372 22 9 25 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_141422_1_623_+ FIG00001189 101 19 103 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_141445_222_623_+ FIG00006691 92 16 92 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_141471_1_623_- FIG00001269 142 21 143 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_141476_1_623_+ FIG00000080 37 11 39 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_141507_283_570_+ FIG00628704 5 2 7 Putative amidotransferase similar to cobyric acid synthase Cobalamin synthesis 2 T2D_unique_141523_1_623_+ FIG00059211 139 21 139 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_141544_1_290_- FIG00002689 74 11 74 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_141560_415_623_+ FIG00002515 18 4 19 4-hydroxybenzoyl-CoA thioesterase family active site Ton and Tol transport systems 2 T2D_unique_141566_332_623_- FIG00044622 8 2 9 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_141573_321_623_+ FIG00004788 12 4 13 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_141589_1_623_- FIG00001209 23 8 27 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_unique_141593_1_286_+ FIG00001407 18 6 20 FKBP-type peptidyl-prolyl cis-trans isomerase fklB (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_141605_1_623_+ FIG00041382 25 7 31 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_141610_1_623_+ FIG00000527 17 4 18 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_141630_1_335_+ FIG00000235 21 6 22 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_141659_1_623_- FIG00000793 163 24 163 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_141683_1_623_+ FIG00050603 112 18 114 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_141699_1_623_+ FIG00623809 114 18 115 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_141722_214_623_+ FIG00133515 30 6 32 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_141754_1_567_+ FIG00000624 31 8 33 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_141775_1_622_+ FIG00543846 9 4 10 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_141781_1_434_+ FIG00001237 121 17 121 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_141817_1_622_- FIG00003174 31 8 33 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_141818_1_467_- FIG00000476 18 5 20 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_141843_1_335_- FIG00041382 85 13 86 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_141853_1_421_+ FIG00000532 7 3 10 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_141872_1_366_+ FIG01954097 26 8 28 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_141872_377_622_+ FIG00455853 63 10 63 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_141901_1_622_+ FIG00049915 56 15 58 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_141906_1_142_- FIG00000038 11 2 11 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_141943_1_622_+ FIG00002541 44 12 45 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_141946_1_622_+ FIG00000146 97 17 99 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_141986_1_622_- FIG00001522 23 6 25 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_141993_417_622_- FIG00451095 23 4 23 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_141996_1_431_- FIG00000812 22 9 43 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_142022_1_286_+ FIG00000025 34 7 35 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_142023_1_474_+ FIG00000782 122 19 123 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_142030_1_622_+ FIG01261528 53 10 55 Na+/H+ antiporter NhaD type Na(+) H(+) antiporter 1 T2D_unique_142038_1_622_+ FIG00000283 96 17 97 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_142075_55_622_- FIG00000504 51 10 52 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_142076_101_268_- FIG00000338 15 4 16 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_142086_1_622_+ FIG00044622 11 4 14 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_142089_434_622_+ FIG00002265 17 4 18 Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE Maltose and Maltodextrin Utilization 1.x T2D_unique_142093_1_444_+ FIG00004218 104 17 104 Evolved beta-D-galactosidase transcriptional repressor Lactose utilization 1.00 T2D_unique_142096_298_621_- FIG00024073 9 3 10 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_142118_1_621_+ FIG01266244 31 8 34 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_142124_1_166_- FIG00001253 23 4 24 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_142138_1_621_- FIG00051025 20 6 22 Predicted sialic acid transporter Sialic Acid Metabolism 1.x T2D_unique_142145_122_621_+ FIG00018865 35 8 36 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_142212_1_621_- FIG00035113 111 18 111 Aerotaxis sensor receptor protein Bacterial Chemotaxis 9 T2D_unique_142229_1_262_- FIG00133978 57 10 57 Ureidoglycolate dehydrogenase (EC 1.1.1.154) Allantoin Utilization X T2D_unique_142243_1_381_+ FIG00009682 44 8 45 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_142271_1_621_+ FIG00000289 9 4 16 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_142286_1_382_+ FIG00000081 7 2 9 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_142297_252_621_- FIG00132630 8 4 10 Ferric uptake regulation protein FUR Oxidative stress 1.2 T2D_unique_142298_1_621_- FIG00000383 161 25 161 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_142313_306_621_+ FIG00016132 4 2 5 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_unique_142320_1_309_+ FIG00000221 36 8 37 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_142320_326_621_+ FIG00085033 69 11 70 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_142341_166_621_+ FIG00000450 27 7 29 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_142359_390_621_+ FIG00001980 5 3 13 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_142388_1_300_- FIG00010844 18 5 19 Flavodoxin Flavodoxin 1 T2D_unique_142407_1_621_+ FIG00034851 28 8 29 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_142432_1_621_- FIG00034851 29 12 37 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_142438_1_621_+ FIG00052605 187 25 187 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_142457_1_620_- FIG00009682 145 23 145 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_142466_414_620_- FIG00007079 21 5 22 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_142472_220_620_- FIG00132630 83 14 84 Ferric uptake regulation protein FUR Oxidative stress 1.2 T2D_unique_142478_175_620_+ FIG01954097 4 4 7 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_142485_1_620_- FIG00046929 12 5 14 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_142518_246_620_+ FIG00138258 61 10 62 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_142525_1_620_- FIG01304538 113 19 113 Unspecified monosaccharide ABC transport system, ATP-binding protein CBSS-257314.1.peg.676 4.x T2D_unique_142536_417_620_- FIG00000243 37 5 37 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_142537_1_620_+ FIG00168885 42 7 43 Cellobiose phosphorylase (EC 2.4.1.-) Beta-Glucoside Metabolism 2.bc T2D_unique_142612_413_620_+ FIG00000420 32 6 32 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_142613_1_620_+ FIG00093180 18 3 20 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_142661_1_620_- FIG00130900 3 3 5 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_unique_142675_150_620_- FIG00134060 24 6 25 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_142697_1_620_+ FIG00000372 8 3 10 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_142718_1_135_+ FIG00000865 32 5 32 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_142729_41_620_+ FIG00001000 24 9 27 Sulfate and thiosulfate binding protein CysP Cysteine Biosynthesis 2.17 T2D_unique_142753_1_620_- FIG00001869 7 2 8 Exoribonuclease II (EC 3.1.13.1) RNA processing and degradation, bacterial 1 T2D_unique_142830_1_311_- FIG00034293 24 7 25 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_142837_1_367_+ FIG00041038 13 4 15 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_142842_1_368_+ FIG00000130 29 6 30 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_142849_56_619_- FIG00048014 113 19 114 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_142911_1_431_- FIG00000441 9 2 11 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_142913_451_619_- FIG00085033 19 3 19 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_142970_1_307_+ FIG00000834 14 3 16 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_142995_310_619_+ FIG00000146 30 6 32 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_143018_320_619_- FIG00000721 71 10 71 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_143033_1_619_+ FIG01007502 105 19 107 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_143051_262_619_+ FIG00067681 7 4 8 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_143097_1_211_- FIG00093180 18 5 19 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_143097_212_466_- FIG00093180 10 3 11 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_143100_1_191_- FIG00028203 12 2 12 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_143102_1_144_- FIG00006463 25 4 26 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_143106_1_619_+ FIG00001548 13 7 15 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_143110_221_619_- FIG00340292 81 14 81 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_143128_1_285_+ FIG00057709 11 4 13 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_143142_1_512_+ FIG00010600 125 17 126 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_143147_1_330_+ FIG00019251 80 13 80 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_143147_349_618_+ FIG00038814 55 8 56 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_143175_1_618_- FIG00024851 59 13 60 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_143179_1_618_+ FIG00012945 136 23 136 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_143194_88_618_+ FIG00051025 13 7 15 Predicted sialic acid transporter Sialic Acid Metabolism 1.x T2D_unique_143196_1_425_+ FIG00000017 34 8 35 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_143215_1_618_- FIG00000477 93 19 96 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_143222_1_618_+ FIG00554193 8 4 10 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_143228_1_616_+ FIG00001469 28 7 29 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_143231_283_618_+ FIG00000391 28 6 29 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_143305_462_618_- FIG00002034 13 3 14 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_143315_1_618_- FIG00012267 166 25 166 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_143327_1_618_+ FIG00000085 25 7 46 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_143353_1_574_+ FIG00000387 40 12 42 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_143357_1_357_+ FIG00000834 86 14 86 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_143369_186_618_+ FIG00138258 123 17 123 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_143371_1_559_- FIG00719736 148 22 148 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_143395_1_618_- FIG00006128 146 24 146 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_143419_1_618_- FIG00001712 144 23 144 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_143501_1_617_+ FIG00000372 14 4 16 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_143525_1_317_+ FIG00000356 22 5 24 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_143526_1_204_+ FIG00047509 45 8 46 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_143530_1_617_+ FIG00001188 24 6 26 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_143535_184_617_+ FIG00001194 77 13 78 Rrf2 family transcriptional regulator, group III Rrf2 family transcriptional regulators 4 T2D_unique_143540_1_617_- FIG00001069 27 5 30 Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_143554_319_617_- FIG00022899 12 4 13 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_143593_1_617_+ FIG00000356 36 8 37 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_143607_1_255_+ FIG00008507 14 3 15 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_143629_1_402_+ FIG00001366 10 4 12 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_143629_453_617_+ FIG00000415 37 6 37 Ribose 5-phosphate isomerase A (EC 5.3.1.6) Glycolate, glyoxylate interconversions ? T2D_unique_143679_1_296_- FIG01318274 15 5 16 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_143686_1_617_+ FIG00136922 157 24 157 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_143696_1_528_- FIG00034293 127 19 127 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_143708_1_617_+ FIG00002034 66 11 67 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_143709_21_617_- FIG00002300 30 6 32 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_143714_1_617_+ FIG00475203 21 5 25 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_143766_454_617_+ FIG00000584 9 3 11 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_143778_361_617_+ FIG00107349 34 6 35 Glycine/sarcosine/betaine reductase component C chain 1 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_143804_1_617_- FIG00048014 5 2 6 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_143843_1_616_- FIG00005728 7 4 9 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_143850_1_616_- FIG00006463 139 23 140 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_143864_1_246_+ FIG00000659 44 8 44 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_143868_65_277_- FIG00000584 4 3 5 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_143876_142_616_+ FIG00022300 20 6 21 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_143892_1_616_- FIG00000210 115 21 115 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_143940_1_616_+ FIG00021289 126 20 127 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_143959_1_616_+ FIG00041038 3 3 6 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_143960_1_363_+ FIG00001022 32 7 33 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_143980_1_239_- FIG00138468 36 7 36 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_143980_265_616_- FIG00019212 94 14 94 Cobalt-precorrin-6x reductase (EC 1.3.1.54) Cobalamin synthesis 2 T2D_unique_143997_134_616_- FIG00031250 112 16 113 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_144013_1_616_+ FIG00038343 7 4 29 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_144026_1_616_+ FIG00001469 34 9 37 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_144033_1_616_+ FIG00024401 55 12 56 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_144058_1_616_+ FIG00055715 142 23 142 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_144068_1_419_- FIG00719736 28 7 29 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_144083_1_547_- FIG00008736 52 11 53 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_144104_347_616_- FIG00134060 29 5 31 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_144120_1_246_+ FIG00034392 10 3 11 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_144122_1_616_- FIG01304149 118 18 127 Glutathione S-transferase domain protein CBSS-89187.3.peg.2957 1 T2D_unique_144126_1_616_+ FIG00000139 28 8 31 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_144176_136_615_- FIG00001364 119 18 119 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Glycine and Serine Utilization 1.12 T2D_unique_144195_401_615_+ FIG00000156 6 3 8 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_144209_1_432_+ FIG00013525 17 7 19 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_unique_144217_1_615_- FIG00009450 6 3 8 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_144222_1_615_+ FIG01954097 7 5 10 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_144225_1_615_+ FIG00029916 170 25 170 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_144229_344_615_+ FIG00000085 31 8 32 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_144286_147_615_- FIG00002354 28 6 30 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_144289_381_615_+ FIG00079740 15 4 16 Xyloside transporter XynT Xylose utilization 1 T2D_unique_144342_1_270_+ FIG00000243 15 5 16 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_144364_1_615_- FIG00003788 11 7 14 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_144382_1_615_- FIG00000738 76 14 78 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_144407_88_615_- FIG00012945 3 3 7 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_144435_429_615_+ FIG00000770 49 7 49 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_144468_1_403_+ FIG00000263 37 9 39 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_144477_1_615_+ FIG00001469 34 9 36 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_144482_1_615_- FIG00076542 106 16 107 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_144500_361_614_+ FIG00000151 62 9 63 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_144504_1_372_+ FIG00003520 8 6 9 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_144509_1_614_- FIG00018369 63 12 64 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_144556_1_614_- FIG00047414 55 14 58 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_144558_224_614_+ FIG00000304 33 9 34 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_144560_384_614_- FIG01016270 59 8 59 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_144589_174_614_- FIG00024930 14 4 16 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_144620_1_614_- FIG00000243 162 24 163 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_144648_1_427_- FIG00006235 92 16 93 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_unique_144680_1_504_+ FIG01306622 39 9 46 O-succinylbenzoate synthase (EC 4.2.1.113) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_144683_1_614_- FIG00000234 120 22 121 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_144687_36_614_- FIG00017495 135 22 135 Nudix-related transcriptional regulator NrtR NAD and NADP cofactor biosynthesis global E T2D_unique_144767_1_614_+ FIG00451095 49 12 50 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_144773_100_614_- FIG00004589 73 12 74 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_144786_1_614_+ FIG00000356 25 6 26 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_144792_292_614_+ FIG00006764 25 7 27 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_144827_1_614_+ FIG00000080 37 14 50 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_144858_1_613_- FIG00001548 162 22 162 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_144865_1_490_+ FIG00054459 13 5 14 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_144880_1_420_+ FIG00000086 7 3 8 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_144895_1_171_+ FIG00000147 13 3 16 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_144907_178_613_+ FIG00018865 93 15 93 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_144920_1_613_+ FIG00000111 101 20 102 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_144928_1_399_+ FIG00000166 50 10 52 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_144937_1_379_+ FIG00003406 35 7 36 AmpG permease Recycling of Peptidoglycan Amino Acids 1 T2D_unique_144969_1_252_+ FIG01954097 6 4 8 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_144969_267_613_+ FIG00006691 57 9 59 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_144988_171_563_- FIG00059211 5 3 7 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_145007_1_613_- FIG00000504 61 12 63 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_145015_1_139_+ FIG00064110 17 4 18 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_145050_237_613_- FIG00035175 47 10 49 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_145060_1_613_- FIG01260980 162 22 162 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_145114_1_613_- FIG00041038 154 23 155 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_145121_333_613_- FIG00001198 13 4 15 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_145128_463_613_- FIG00000214 12 4 12 LSU ribosomal protein L19p Ribosome LSU bacterial 9 T2D_unique_145155_1_524_- FIG00045575 5 2 6 O-antigen export system, permease protein Rhamnose containing glycans 4.1 T2D_unique_145203_1_613_- FIG01271998 34 7 36 Possible hypoxanthine oxidase XdhD (EC 1.-.-.-) Purine conversions 4.1118100 T2D_unique_145204_1_249_+ FIG00000174 55 9 55 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_unique_145223_1_613_- FIG00002002 150 24 150 Ascorbate-specific PTS system, EIIC component L-ascorbate utilization (and related gene clusters) 29 T2D_unique_145234_1_378_+ FIG00000560 24 6 25 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_145257_1_612_- FIG00006128 5 5 9 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_145276_1_612_+ FIG00000224 126 20 127 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_145306_1_612_+ FIG00000145 33 8 36 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_145310_1_612_- FIG00041038 60 16 62 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_145312_1_374_- FIG00000312 39 7 40 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_145314_1_612_- FIG00000210 113 18 114 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_145355_1_402_+ FIG00001469 23 5 25 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_145370_179_612_+ FIG00000717 64 14 65 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_145382_120_612_+ FIG00007147 111 16 113 Glycosyltransferase LafB, responsible for the formation of Gal-Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_145385_1_473_+ FIG01260980 21 9 23 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_145389_244_612_+ FIG00001818 50 10 51 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_145398_1_281_+ FIG00002718 20 5 21 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_145398_283_612_+ FIG00002742 4 3 5 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_145410_402_612_- FIG01270039 43 7 43 Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_unique_145418_201_612_+ FIG00018396 14 4 16 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_145431_407_612_+ FIG00000624 13 3 15 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_145450_220_390_+ FIG00034293 24 5 24 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_145486_117_612_- FIG00000122 5 2 7 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_145490_91_612_- FIG00000824 5 4 6 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_145505_1_498_- FIG00001188 134 20 134 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_145536_341_612_- FIG00000036 19 3 20 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_145537_263_612_- FIG00000176 27 7 30 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_145546_1_612_+ FIG00004763 6 3 8 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_145550_1_499_+ FIG00000175 58 9 60 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_145561_1_612_- FIG00002968 18 4 19 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_145578_1_605_+ FIG00021289 46 10 48 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_145582_1_208_- FIG01010650 55 8 55 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_145623_452_611_+ FIG00000163 28 5 29 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_145634_1_611_- FIG00076542 88 17 89 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_145639_1_450_+ FIG00002689 112 17 112 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_145639_465_611_+ FIG00134060 38 5 38 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_145642_276_611_- FIG00719736 90 13 90 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_145677_1_611_+ FIG00132617 73 15 74 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_145747_172_611_+ FIG00135554 118 17 118 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_145754_477_611_+ FIG00012267 9 2 11 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_145760_154_363_- FIG00000070 14 5 15 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_145768_1_611_- FIG00001903 17 4 22 Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) Glutaredoxins 1 T2D_unique_145785_1_611_- FIG01260980 172 24 173 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_145795_1_611_- FIG01260980 17 7 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_145804_341_611_+ FIG00016663 5 2 7 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_145820_1_611_+ FIG00229198 35 10 40 Cysteine desulfurase (EC 2.8.1.7), IscS subfamily Alanine biosynthesis A.123 T2D_unique_145848_1_611_- FIG00001824 106 19 106 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_145890_1_611_+ FIG00030191 37 11 38 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_145916_1_611_- FIG00011468 3 2 5 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_145917_345_611_- FIG00000383 5 2 6 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_145919_1_611_+ FIG00000402 42 9 43 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_145931_1_611_+ FIG00000402 171 24 171 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_145955_44_611_+ FIG00018369 5 6 17 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_145998_1_437_- FIG00000206 16 3 17 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_146024_449_610_+ FIG00000210 25 5 26 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_146030_1_610_+ FIG00042267 97 18 97 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_146055_1_368_- FIG00024401 110 15 110 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_146071_109_610_- FIG00000494 15 4 16 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_146105_1_610_- FIG00002273 72 15 82 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_146118_1_314_- FIG00005121 6 3 7 FIG005121: SAM-dependent methyltransferase (EC 2.1.1.-) CBSS-228410.1.peg.134 1.x T2D_unique_146131_275_421_- FIG00001067 17 3 17 Rubrerythrin Oxidative stress 1.2 T2D_unique_146135_298_610_+ FIG00005283 46 9 47 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_146144_1_556_- FIG00135554 152 21 152 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_146156_1_172_+ FIG00000531 17 5 19 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_146187_128_610_- FIG00000435 37 8 39 Exodeoxyribonuclease VII small subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_146196_1_153_+ FIG00000584 7 4 8 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_146204_420_610_- FIG00008941 3 3 5 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_146244_273_610_- FIG00000402 7 3 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_146254_175_351_- FIG00002914 41 6 41 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_146260_1_610_+ FIG00001522 162 25 162 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_146280_374_610_+ FIG01260980 14 4 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_146299_1_224_+ FIG00009628 16 4 17 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_146328_369_610_+ FIG00000208 19 3 20 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_146366_1_610_- FIG00005022 70 17 71 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_146385_1_609_+ FIG00046929 28 6 29 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_146388_1_242_+ FIG00057709 11 4 12 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_146393_392_609_- FIG00109688 41 7 42 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_146419_411_609_+ FIG00000114 12 3 12 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_146488_177_512_+ FIG00138171 49 9 52 Queuosine biosynthesis QueD, PTPS-I Zinc regulated enzymes 1 T2D_unique_146502_236_499_- FIG00005308 10 2 11 Catabolite repression HPr-like protein Crh HPr catabolite repression system 1 T2D_unique_146517_1_587_- FIG00000001 136 22 136 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_146544_1_609_+ FIG00132666 3 3 6 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_146573_1_448_+ FIG00001687 16 4 18 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_146605_1_404_- FIG00067300 7 3 9 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_146605_443_609_- FIG00000241 18 4 19 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_146609_1_343_+ FIG00029916 88 13 88 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_146609_358_609_+ FIG00011115 50 8 51 PTS system, cellobiose-specific IIA component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_146616_340_609_- FIG00521220 76 11 76 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_146643_1_567_- FIG00005237 129 22 129 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_146645_116_609_- FIG00000114 18 6 20 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_146679_1_609_- FIG00000085 38 13 39 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_146693_1_255_+ FIG00003845 66 10 66 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_146725_1_360_+ FIG00004021 45 9 46 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_146725_368_609_- FIG00010134 52 8 52 Methionine transporter MetT Methionine Degradation 3 T2D_unique_146726_1_609_+ FIG00000532 117 20 118 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_146731_329_608_+ FIG00002486 3 2 5 L-fuculose phosphate aldolase (EC 4.1.2.17) L-fucose utilization 1 T2D_unique_146743_1_608_+ FIG00719736 31 10 33 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_146816_1_608_- FIG00028461 57 10 59 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_146820_1_231_+ FIG00000404 27 6 29 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_146829_1_608_+ FIG00001548 153 21 154 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_146843_1_381_- FIG00001366 6 5 8 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_146851_1_608_- FIG00003174 69 12 70 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_146860_1_166_+ FIG00139238 3 3 5 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_146889_1_463_- FIG00058189 31 8 34 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_unique_146891_90_608_- FIG00001732 135 19 136 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_146967_12_608_+ FIG00091606 176 24 176 Methionine synthase activation domain (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_146968_1_209_- FIG00001347 3 2 5 Chitinase (EC 3.2.1.14) Chitin and N-acetylglucosamine utilization 2 T2D_unique_146970_1_250_+ FIG01955857 23 6 24 Sensor protein of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_unique_146970_330_608_+ FIG00001676 13 5 14 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_146979_1_608_+ FIG00014596 115 22 116 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_146997_1_260_+ FIG00000164 4 2 5 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_unique_147001_1_398_- FIG00098273 98 16 98 Glycine/sarcosine/betaine reductase component C chain 2 Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_147016_1_608_+ FIG00000476 107 18 110 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_147025_319_608_+ FIG00020185 9 5 11 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_147042_1_608_+ FIG00132617 5 4 8 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_147051_1_608_- FIG00016514 50 11 52 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_147059_107_608_+ FIG00007137 7 2 9 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_147061_1_608_+ FIG01955774 7 4 10 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_147075_457_608_+ FIG00000542 12 4 13 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_147108_140_367_+ FIG00002328 11 3 13 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_147112_1_608_- FIG00001029 148 23 148 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_147211_250_477_- FIG00005628 17 6 18 KH domain RNA binding protein YlqC KH domain RNA binding protein YlqC 1.11 T2D_unique_147221_420_607_+ FIG00001675 3 3 5 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_147240_1_406_- FIG00048453 8 4 10 Single-stranded-DNA-specific exonuclease RecJ, clostridial paralog DNA Repair Base Excision 4 T2D_unique_147260_1_607_- FIG00051439 63 11 65 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_147264_1_607_- FIG00475203 3 3 5 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_147283_1_484_- FIG00945384 96 17 97 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_147323_1_232_- FIG00062054 6 2 8 Putative glycosyltransferase protein CBSS-258594.1.peg.3339 1 T2D_unique_147360_1_196_+ FIG00031250 45 7 46 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_147401_1_607_+ FIG00073301 3 2 5 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_147427_1_607_- FIG00046929 66 15 68 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_147438_85_468_+ FIG00006706 66 11 67 Protein of unknown function identified by role in sporulation (SpoVG) Sporulation-associated proteins with broader functions 2.111 T2D_unique_147460_1_579_+ FIG00074225 3 4 6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_147472_1_147_+ FIG00054459 21 5 21 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_147472_167_607_+ FIG00000076 121 17 121 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_147477_478_607_+ FIG01304195 18 4 18 ABC transporter involved in cytochrome c biogenesis, ATPase component CcmA Biogenesis of c-type cytochromes 1.1 T2D_unique_147492_1_175_+ FIG00025216 10 2 13 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_147493_251_457_- FIG00089051 14 4 15 Small acid-soluble spore protein, beta-type SASP Small acid-soluble spore proteins 1 T2D_unique_147496_1_259_+ FIG00000025 5 4 7 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_147497_1_191_- FIG00074196 5 2 6 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_147510_177_607_- FIG00003955 24 8 25 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_147546_1_339_- FIG00000267 25 6 27 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_147546_352_606_- FIG00000404 22 5 23 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_147571_1_484_+ FIG00000838 46 8 47 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_147621_1_276_- FIG00005529 59 10 60 Nitrate/nitrite transporter Nitrate and nitrite ammonification 1 T2D_unique_147623_141_606_- FIG00000402 38 8 39 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_147624_77_606_+ FIG00000234 49 13 54 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_147697_185_606_+ FIG00003435 105 16 105 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_147705_1_606_- FIG00229386 60 16 61 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_147711_1_509_- FIG00003955 53 10 55 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_147723_303_542_+ FIG00005172 14 3 15 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_147737_1_225_+ FIG00003997 44 7 45 Protein with similarity to RtcB Translation termination factors bacterial 1.13 T2D_unique_147737_412_606_- FIG00018396 9 3 10 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_147757_1_606_+ FIG00000552 16 4 18 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_147806_100_606_+ FIG01016270 28 7 30 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_147814_1_606_+ FIG00000207 11 5 13 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_147894_65_606_- FIG00000256 8 4 10 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_147946_1_209_+ FIG00005237 22 4 23 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_147953_1_605_- FIG00067681 96 17 97 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_147965_1_605_+ FIG00001604 47 12 49 Ornithine decarboxylase (EC 4.1.1.17) Polyamine Metabolism 2 T2D_unique_147970_1_605_- FIG00006764 3 2 5 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_147975_198_605_+ FIG00008285 65 10 66 Ribose ABC transporter, periplasmic ribose-binding protein RbsB (TC 3.A.1.2.1) Bacterial Chemotaxis 9 T2D_unique_147995_313_605_+ FIG00561498 73 11 73 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_148013_281_605_- FIG00001635 16 5 18 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_148043_1_605_+ FIG00048014 11 3 13 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_148053_1_605_- FIG00003433 159 24 159 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_148085_1_200_+ FIG00451095 3 2 4 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_148085_217_605_+ FIG00004788 22 6 24 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_148100_1_368_+ FIG00000341 49 10 51 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_148132_1_202_- FIG00004021 42 7 42 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_148144_1_605_+ FIG00007339 72 12 74 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_148170_1_513_+ FIG00007586 13 6 15 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_148173_33_605_- FIG00005237 8 3 9 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_148182_137_605_- FIG00004078 61 12 62 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_148185_1_568_+ FIG00001750 13 3 15 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_148194_1_605_- FIG00002130 5 3 7 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_148220_1_605_+ FIG00004518 103 19 104 tRNA nucleotidyltransferase, A-adding (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_148252_1_605_+ FIG00000188 58 12 59 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_148265_1_131_- FIG00132967 24 4 24 Iron(III) dicitrate transport ATP-binding protein FecE (TC 3.A.1.14.1) Flavohaemoglobin 1 T2D_unique_148283_174_604_- FIG00000013 4 2 5 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_148292_1_506_+ FIG00012349 30 6 32 Heme transporter analogous to IsdDEF, ATP-binding protein Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_148296_473_604_- FIG00006092 15 4 16 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_148299_1_604_- FIG01260980 35 10 37 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_148308_1_604_+ FIG00001278 75 12 76 GMP reductase (EC 1.7.1.7) Purine conversions 4.1118100 T2D_unique_148311_1_471_+ FIG00057709 7 3 9 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_148323_1_497_+ FIG00000877 42 11 45 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_148337_1_367_+ FIG00001968 81 13 82 PTS system, mannose-specific IIB component (EC 2.7.1.69) Sialic Acid Metabolism 1.x T2D_unique_148350_1_278_- FIG00000001 21 6 22 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_148362_1_604_- FIG00025216 46 12 48 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_148368_1_492_- FIG00000317 20 7 22 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_148394_1_604_- FIG00074196 154 23 155 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_148396_1_604_- FIG00006551 6 3 8 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_148397_1_604_+ FIG00021289 77 15 78 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_148436_1_604_+ FIG00846773 3 4 5 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_148442_1_604_+ FIG00018369 79 17 80 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_148450_1_604_+ FIG00000425 16 7 18 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_148482_467_604_- FIG01280345 10 3 11 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_148507_1_604_+ FIG00080955 3 3 5 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_148527_371_604_+ FIG00719736 48 9 48 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_148542_128_604_- FIG00229257 117 19 117 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_148548_1_604_+ FIG00000441 113 17 114 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_148557_1_383_+ FIG00041382 78 13 79 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_148557_416_604_+ FIG00080231 22 5 23 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_148567_303_604_- FIG00001548 27 6 28 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_148568_1_164_- FIG00032483 12 4 13 PTS system, fructose- and mannose-inducible IID component (EC 2.7.1.69) Fructose and Mannose Inducible PTS 2 T2D_unique_148600_1_604_+ FIG00000145 56 13 57 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_148666_1_398_- FIG00034851 37 10 41 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_148674_1_319_+ FIG00000812 62 10 62 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_148689_1_603_- FIG00000356 20 5 21 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_148698_1_313_- FIG00001076 54 10 55 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_148738_1_510_+ FIG00000212 85 15 86 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_148821_1_332_+ FIG00000043 24 5 25 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_148827_1_603_+ FIG00007059 27 7 29 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_148857_298_603_+ FIG00745599 13 4 18 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_148881_1_449_- FIG00002914 12 5 15 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_148881_461_603_- FIG00000422 17 4 18 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_148887_1_603_- FIG00000001 5 3 7 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_148894_1_557_+ FIG00018561 55 12 56 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_148905_1_457_+ FIG00000595 18 4 19 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_148922_1_603_- FIG00048014 125 22 126 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_148927_1_603_- FIG00002818 60 12 62 Inner membrane protein translocase component YidC, long form Cell Division Subsystem including YidCD 1 T2D_unique_148937_310_603_- FIG00000202 64 11 64 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_148948_1_603_+ FIG00000088 167 24 167 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_148963_228_603_+ FIG01290653 4 2 6 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_148979_1_496_+ FIG00000681 11 3 13 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_unique_148990_1_238_- FIG00003410 4 2 5 Tagatose-6-phosphate kinase AgaZ (EC 2.7.1.144) N-Acetyl-Galactosamine and Galactosamine Utilization B.x T2D_unique_148990_337_603_- FIG00076542 20 5 21 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_149009_1_537_- FIG00000084 8 5 9 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_149014_1_163_- FIG00005237 44 6 44 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_149037_1_327_- FIG01255877 53 10 54 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_149055_332_602_- FIG00000899 17 5 18 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_149070_129_602_+ FIG00048014 83 13 84 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_149077_1_338_+ FIG00028203 11 7 18 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_149092_1_369_- FIG00000494 9 4 12 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_149105_375_602_- FIG00000095 47 8 48 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_149117_1_481_- FIG00229257 89 14 90 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_149130_461_602_- FIG00104848 39 5 39 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_149148_1_223_+ FIG00000391 14 4 15 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_149166_1_201_+ FIG00451095 11 4 12 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_149179_1_602_- FIG00000396 5 6 20 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_149200_220_602_- FIG00000659 24 6 26 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_149207_142_602_+ FIG00003605 34 9 35 CoA-acylating propionaldehyde dehydrogenase Fermentations: Mixed acid 1 T2D_unique_149210_1_317_- FIG00003435 59 11 60 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_149251_1_602_+ FIG00005727 60 13 62 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_149255_130_602_- FIG00007514 38 6 39 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_149308_1_602_- FIG00001067 29 5 30 Rubrerythrin Oxidative stress 1.2 T2D_unique_149336_1_602_+ FIG00000333 30 10 33 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_149438_128_601_- FIG00004058 6 3 9 Aminopeptidase Y (Arg, Lys, Leu preference) (EC 3.4.11.15) EC 3.4.11.- Aminopeptidases 1 T2D_unique_149446_1_350_- FIG00007901 83 13 83 rhamnose-containing polysacharide translocation permease Rhamnose containing glycans 4.1 T2D_unique_149468_1_601_- FIG00063189 126 21 126 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_149470_1_307_+ FIG00000494 12 4 13 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_149509_1_422_+ FIG00009229 6 2 7 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_149531_1_601_- FIG00000001 28 8 30 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_149536_261_601_- FIG00067750 76 11 77 Metal-dependent hydrolases of the beta-lactamase superfamily II Beta-lactamase 1 T2D_unique_149538_1_245_- FIG00001882 64 9 64 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_149551_304_601_+ FIG00003394 18 3 20 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_149552_45_542_+ FIG00067300 48 9 50 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_149558_2_601_- FIG00000085 68 12 69 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_149561_1_601_- FIG00000476 147 22 147 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_149571_1_159_- FIG00004589 19 4 19 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_149582_1_577_+ FIG01260980 77 13 97 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_149599_1_411_+ FIG00000482 10 5 11 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_149606_1_301_- FIG00066643 38 6 39 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_149613_1_495_+ FIG00904859 22 5 24 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_unique_149614_1_138_- FIG00028476 12 3 13 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_149639_330_601_- FIG01956032 10 3 11 Tagatose 1,6-bisphosphate aldolase (EC 4.1.2.40) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_149649_1_601_- FIG00080231 143 22 143 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_149667_258_601_+ FIG00010134 40 7 41 Methionine transporter MetT Methionine Degradation 3 T2D_unique_149678_1_279_+ FIG00019251 8 3 12 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_149753_250_600_- FIG00000494 18 5 21 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_149758_384_600_- FIG00000173 48 7 49 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_149788_1_423_- FIG00001656 24 5 26 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_unique_149795_262_561_+ FIG00028461 25 4 26 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_149832_1_482_+ FIG01260980 17 5 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_149835_1_540_+ FIG00018865 5 7 16 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_149839_1_600_- FIG00000156 111 19 112 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_149856_1_600_+ FIG00085033 12 5 13 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_149889_1_221_- FIG00006953 46 8 46 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_unique_149893_1_600_+ FIG00066643 28 7 30 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_149894_403_600_+ FIG00033206 4 3 6 Enoyl-CoA hydratase (EC 4.2.1.17) Polyhydroxybutyrate metabolism 5.6 T2D_unique_149932_336_600_- FIG00139238 44 8 44 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_149946_1_176_- FIG00004078 7 3 9 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_149954_1_600_- FIG01260980 33 10 35 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_149966_135_599_+ FIG00134135 34 10 36 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_149988_1_600_+ FIG00031250 174 24 174 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_150011_1_336_- FIG00001882 72 11 72 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_150012_288_600_- FIG00010600 8 5 9 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_150024_377_600_+ FIG00000365 7 3 9 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_150025_1_354_+ FIG00075702 79 12 79 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_150043_1_600_- FIG00001088 35 10 36 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_150055_1_600_- FIG00001932 107 19 108 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_150067_1_600_- FIG00001469 18 8 21 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_150086_274_600_- FIG00116638 8 3 10 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_150115_430_600_- FIG00001059 35 5 36 TolA protein Ton and Tol transport systems 2 T2D_unique_150116_1_342_- FIG00055715 17 4 19 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_150117_404_600_+ FIG00018865 23 5 23 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_150123_1_600_- FIG00004568 25 6 26 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Alkanesulfonate assimilation 9.? T2D_unique_150140_1_600_+ FIG00034293 26 6 28 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_150160_1_575_+ FIG00796613 133 21 133 Beta-phosphoglucomutase (EC 5.4.2.6) Maltose and Maltodextrin Utilization 1.x T2D_unique_150177_1_599_+ FIG00002470 38 7 39 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_150236_184_599_+ FIG00016566 22 7 23 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_150244_235_599_+ FIG00134342 10 3 12 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_150248_465_599_+ FIG00000214 9 2 10 LSU ribosomal protein L19p Ribosome LSU bacterial 9 T2D_unique_150250_97_599_+ FIG00006463 12 5 16 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_150271_281_599_- FIG00000614 16 4 19 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_unique_150290_126_599_- FIG00000522 109 17 109 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_150305_1_223_- FIG00000892 4 2 5 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_150335_1_196_+ FIG00000477 30 6 31 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_150384_229_599_- FIG00000131 46 9 47 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_150397_1_396_- FIG00023004 43 9 44 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_150397_420_599_- FIG00846773 32 6 33 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_150409_1_537_+ FIG00016187 145 21 145 Arginine utilization protein RocB Arginine and Ornithine Degradation 1.34 T2D_unique_150418_1_599_- FIG00000463 36 10 38 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_150455_1_599_+ FIG00719736 11 5 13 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_150456_1_599_+ FIG00000624 51 11 52 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_150462_1_504_+ FIG00000358 15 5 16 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_150473_1_160_- FIG00001311 8 2 9 N-Acetylneuraminate cytidylyltransferase (EC 2.7.7.43) Sialic Acid Metabolism 1.x T2D_unique_150477_1_549_- FIG00000404 140 21 140 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_150482_1_362_+ FIG00022976 35 8 36 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_150500_1_437_+ FIG00006151 22 5 25 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_150506_1_128_+ FIG00001548 7 2 7 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_150524_250_546_+ FIG00000426 6 3 8 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY Bacterial Chemotaxis 9 T2D_unique_150551_1_266_- FIG00000043 19 4 21 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_150562_1_598_- FIG01304712 119 21 119 High-affinity leucine-specific transport system, periplasmic binding protein LivK (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_150589_5_319_- FIG00005727 11 4 12 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_150647_1_598_+ FIG00000365 65 12 67 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_150672_1_503_- FIG00094401 132 20 132 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_150675_1_459_+ FIG00001145 105 18 105 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_150689_191_598_- FIG00133515 109 16 109 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_150695_1_598_- FIG01260980 113 18 114 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_150706_150_598_- FIG00016110 66 11 67 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_150707_1_168_- FIG00000309 36 6 36 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_150709_1_598_- FIG00011423 95 18 96 Ferredoxin reductase Anaerobic respiratory reductases 3 T2D_unique_150729_1_501_+ FIG00000132 93 16 104 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_150739_1_598_+ FIG00010844 44 10 46 Flavodoxin Flavodoxin 1 T2D_unique_150745_1_598_- FIG00058830 29 8 42 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_150750_1_577_+ FIG00000402 40 10 43 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_150775_1_598_- FIG00000476 46 13 47 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_150801_1_354_- FIG00000001 8 4 9 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_150809_1_401_+ FIG00051439 7 5 19 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_150810_1_319_- FIG00003788 5 3 11 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_150814_1_598_+ FIG00000088 50 14 51 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_150815_1_388_+ FIG00000001 9 4 13 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_150864_287_598_- FIG00000842 25 8 26 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_150870_1_598_+ FIG00129616 30 4 31 GTP-binding protein EngA Universal GTPases 2 T2D_unique_150897_1_597_- FIG00002034 139 23 139 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_150919_1_597_- FIG00000990 49 8 51 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_150928_1_597_+ FIG00009682 61 15 62 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_150939_290_597_+ FIG00001036 74 11 74 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_150948_1_597_+ FIG00134830 105 18 107 Lysine 2,3-aminomutase (EC 5.4.3.2) Lysine degradation 1.0 T2D_unique_150955_1_198_+ FIG00000085 9 2 10 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_150970_1_597_+ FIG00004220 9 5 11 Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5) Protein degradation 1 T2D_unique_150973_1_234_- FIG00000531 6 2 7 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_150975_349_597_+ FIG00000290 12 2 14 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_150999_163_597_+ FIG00006463 85 14 85 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_151038_1_141_+ FIG00000358 25 4 25 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_151047_1_597_+ FIG00001269 7 3 11 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_151136_365_597_+ FIG00001188 62 9 62 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_151166_1_597_- FIG00006463 143 22 143 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_151167_1_597_- FIG00003460 125 20 126 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_151176_1_194_- FIG00004014 4 3 5 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_151184_1_535_+ FIG00001547 140 20 140 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_151190_443_597_- FIG00038611 4 3 5 Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_unique_151194_1_579_- FIG00000168 143 22 144 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_151208_95_597_+ FIG00051439 89 16 91 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_151241_422_597_+ FIG01303775 33 5 34 GTP-binding protein related to HflX Hfl operon 1.111 T2D_unique_151282_153_597_+ FIG00000376 4 2 5 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_151332_447_596_+ FIG00000095 9 3 10 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_151343_1_596_+ FIG00000080 43 12 45 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_151353_19_596_- FIG00002156 62 12 64 NG,NG-dimethylarginine dimethylaminohydrolase 1 (EC 3.5.3.18) Dimethylarginine metabolism 5 T2D_unique_151359_61_596_- FIG00013638 8 3 10 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_151378_1_596_+ FIG00000323 69 15 70 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_151412_1_472_+ FIG00000317 16 4 18 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_151439_270_596_+ FIG01260980 6 3 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_151441_1_596_- FIG00000456 110 19 112 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_151457_1_596_+ FIG00008736 50 11 53 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_151463_1_470_+ FIG00000260 69 12 70 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_151472_1_474_+ FIG00000298 26 7 27 GTP-binding protein EngB Universal GTPases 2 T2D_unique_151516_202_596_+ FIG00000102 91 14 92 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_151547_348_596_- FIG00002161 7 4 8 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_unique_151573_63_596_- FIG00000812 12 2 14 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_151578_247_540_+ FIG00000308 24 7 26 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_151580_1_596_+ FIG00018699 18 7 19 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_151583_331_596_+ FIG00016132 26 5 27 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_unique_151629_1_596_- FIG00001280 18 6 20 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_151647_37_596_- FIG00001307 65 11 68 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_unique_151686_1_521_- FIG00028461 28 9 30 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_151725_1_182_+ FIG00000465 44 7 44 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_151727_1_595_+ FIG00000156 56 11 58 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_151744_1_595_+ FIG00052605 75 15 76 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_151750_1_595_+ FIG00001020 158 23 159 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_151752_143_595_- FIG00002049 20 7 23 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_151770_1_510_- FIG00000132 19 8 24 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_151775_1_595_+ FIG00000381 121 18 123 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_unique_151799_1_595_- FIG00020370 7 5 9 Phage tape measure Phage tail proteins 2 4 T2D_unique_151835_137_595_- FIG00000408 53 10 54 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_151863_195_595_- FIG00010844 30 7 32 Flavodoxin Flavodoxin 1 T2D_unique_151893_1_595_- FIG00136866 153 23 154 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_151915_301_595_+ FIG00021484 3 3 4 Metallo-beta-lactamase superfamily domain protein in prophage Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_151919_1_390_+ FIG00000494 19 5 20 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_151930_152_595_+ FIG00057709 28 8 30 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_151951_1_573_+ FIG00000420 126 20 126 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_152008_1_595_+ FIG01260980 21 8 23 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_152027_1_272_- FIG00077620 14 6 16 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_152049_1_595_+ FIG00000101 47 10 48 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_152052_1_534_+ FIG00000028 81 18 82 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_152055_1_595_+ FIG00052605 165 24 165 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_152063_1_128_+ FIG00022976 5 2 6 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_152099_1_458_+ FIG00000047 7 5 10 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_152128_1_281_- FIG00001168 36 7 37 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_152143_1_594_- FIG00007025 31 9 33 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_152156_1_594_- FIG00016555 43 10 44 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_152159_1_270_+ FIG00133292 69 11 69 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_152159_287_594_+ FIG00000962 68 11 68 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_152169_1_594_+ FIG00001518 14 7 19 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_152170_308_594_+ FIG00006691 6 3 8 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_152195_1_485_- FIG00000477 38 10 39 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_152205_1_594_- FIG00000404 23 6 25 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_152225_1_264_+ FIG00018699 7 4 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_152226_86_594_+ FIG00000348 54 12 56 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_unique_152234_1_558_+ FIG01260980 9 4 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_152237_1_594_- FIG00000224 53 12 54 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_152248_1_518_- FIG00455853 132 19 132 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_152261_1_321_+ FIG00000645 26 8 27 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_152275_1_363_- FIG00138960 36 7 37 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_unique_152302_217_594_- FIG00000268 67 11 68 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_152312_229_528_- FIG00139157 10 4 23 Type II/IV secretion system protein TadC, associated with Flp pilus assembly Widespread colonization island 2 T2D_unique_152314_1_236_- FIG00000453 11 3 16 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_152326_1_594_- FIG00000323 12 3 13 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_152327_1_391_+ FIG00001676 42 10 43 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_152338_1_594_+ FIG00031250 64 13 66 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_152401_58_594_- FIG00018699 16 6 18 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_152422_261_594_- FIG00003433 6 3 7 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_152433_190_594_+ FIG00000962 96 15 96 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_152438_1_203_+ FIG00000793 38 6 39 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_152503_1_593_+ FIG00001469 4 4 9 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_152504_1_201_- FIG00000107 48 8 48 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_152516_354_593_+ FIG00945384 29 7 30 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_152551_1_593_- FIG00000504 32 7 35 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_152567_1_488_- FIG00133325 16 6 19 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_152582_1_168_+ FIG00028203 34 5 34 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_152587_1_593_+ FIG00026918 23 10 39 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_152609_1_593_- FIG00001824 13 7 17 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_152617_1_583_+ FIG00000001 134 22 134 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_152655_1_579_+ FIG00049915 46 11 48 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_152660_109_593_+ FIG00006151 4 4 6 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_152669_1_210_- FIG00092649 9 4 11 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_152677_234_593_- FIG00008230 16 4 17 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_152700_1_593_+ FIG00000539 53 11 54 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_152713_1_593_+ FIG00000145 121 21 122 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_152719_295_593_+ FIG00000556 41 7 42 2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55) Chorismate Synthesis 1 T2D_unique_152776_1_489_+ FIG00002194 96 16 105 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_152785_1_542_+ FIG01307369 105 16 110 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) Cellulosome 1.x T2D_unique_152793_1_330_+ FIG00001059 44 7 46 TolA protein Ton and Tol transport systems 2 T2D_unique_152794_1_417_+ FIG00000338 72 13 73 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_152797_114_593_+ FIG00000055 98 16 99 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_152804_1_593_+ FIG00050603 104 18 106 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_152816_1_593_- FIG00000176 48 9 49 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_152817_367_593_+ FIG00000085 10 4 12 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_152827_1_393_- FIG00134889 8 2 9 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_152871_1_593_+ FIG01266244 35 8 37 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_152896_1_593_- FIG00687285 98 17 102 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_unique_152909_1_488_+ FIG00031825 147 19 147 Hydrogen peroxide-inducible genes activator DNA-binding regulatory proteins, strays 1 T2D_unique_152926_181_592_- FIG00001522 85 15 85 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_152932_457_592_+ FIG00002914 28 4 28 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_152976_79_592_+ FIG00000959 35 9 36 Sulfate and thiosulfate import ATP-binding protein CysA (EC 3.6.3.25) Cysteine Biosynthesis 2.17 T2D_unique_152986_1_592_- FIG00018699 11 3 13 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_153038_1_425_- FIG00001548 68 11 69 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_153047_375_592_- 4 3 6 Ribosomal large subunit pseudouridine synthase B (EC 4.2.1.70) Two cell division clusters relating to chromosome partitioning 1 T2D_unique_153053_1_590_+ FIG00000143 9 2 12 Translation initiation factor 1 Translation initiation factors bacterial 1.111 T2D_unique_153105_53_451_+ FIG00060517 20 7 21 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_153116_5_391_+ FIG00000214 95 15 95 LSU ribosomal protein L19p Ribosome LSU bacterial 9 T2D_unique_153133_288_592_- FIG00000264 53 10 55 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_unique_153170_1_592_+ FIG00001198 124 19 125 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_153183_76_592_+ FIG00002541 95 16 96 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_153188_1_592_- FIG00000370 60 14 62 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_153194_1_592_+ FIG00000287 6 2 7 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_153270_90_592_- FIG00014777 22 6 27 5-keto-2-deoxygluconokinase (EC 2.7.1.92) Inositol catabolism 5.x T2D_unique_153277_1_592_- FIG00000085 106 16 107 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_153296_306_592_+ FIG00000111 14 5 15 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_153314_381_592_+ FIG00035175 9 2 10 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_153318_1_592_- FIG00005172 7 7 18 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_153323_1_592_- FIG00009156 8 3 16 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_153330_81_500_- FIG00000621 14 5 15 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_153333_116_591_+ FIG00000269 104 16 106 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_153348_1_175_+ FIG00080955 42 7 42 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_153355_1_591_- FIG00000464 26 8 27 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_153367_124_570_- FIG00019251 43 9 44 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_153369_1_294_- FIG00000539 30 7 31 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_153373_1_588_+ FIG00000402 19 6 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_153378_232_591_- FIG00001366 7 2 9 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_153383_1_591_- FIG00132758 33 7 35 Beta-galactosidase large subunit (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_153387_1_591_+ FIG00000329 87 15 89 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_153419_1_591_+ FIG00041038 53 11 54 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_153422_1_399_+ FIG00022976 6 2 12 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_153451_260_591_+ FIG00003756 77 11 78 Maltose-6'-phosphate glucosidase (EC 3.2.1.122) Maltose and Maltodextrin Utilization 1.x T2D_unique_153453_1_582_+ FIG00008736 44 10 46 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_153459_313_591_+ FIG00000555 3 3 4 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_153477_1_591_+ FIG01260980 85 15 86 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_153478_1_591_- FIG00024930 46 12 47 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_153500_1_591_- FIG00000132 24 5 27 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_153509_1_591_- FIG00080955 77 13 85 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_153523_1_591_- FIG00002541 37 8 39 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_153529_350_591_+ FIG00092649 53 9 53 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_153531_116_591_- FIG01955902 16 4 18 Rubredoxin Rubrerythrin 2 T2D_unique_153535_412_591_- FIG00000812 32 6 32 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_153541_1_229_+ FIG00000025 15 5 16 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_153541_261_591_+ FIG00046929 16 5 17 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_153581_121_591_+ FIG00046929 130 19 130 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_153583_410_591_- FIG00000402 7 2 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_153634_1_153_- FIG00075970 16 4 16 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_153634_179_591_- FIG00132787 24 5 25 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_153648_12_591_- FIG00004037 143 21 143 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_153669_1_181_- FIG00000842 39 6 40 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_153673_207_591_- FIG00000001 6 5 8 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_153686_1_591_+ FIG00104852 151 23 151 Predicted D-lactate dehydrogenase, Fe-S protein, FAD/FMN-containing Lactate utilization 3 T2D_unique_153687_1_591_+ FIG00024073 4 3 6 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_153726_130_590_- FIG00030688 99 16 100 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_153727_1_590_- FIG00000165 35 8 38 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_153744_1_590_+ FIG00000132 44 10 45 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_153777_1_590_- FIG00016663 3 2 5 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_153779_1_525_- FIG00002803 18 6 20 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_153806_1_479_+ FIG00038920 3 2 4 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_153810_1_590_+ FIG00000111 129 20 132 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_153815_1_590_+ FIG00000449 15 4 16 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_153867_1_590_+ FIG01260980 9 3 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_153880_1_541_+ FIG00719736 59 11 62 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_153901_1_590_- FIG00007157 5 3 6 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_153915_1_324_+ FIG00000402 74 12 74 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_153923_1_590_- FIG00001440 25 8 26 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_153957_1_590_- FIG00009564 138 22 139 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_153961_1_590_- FIG00000210 38 11 40 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_153973_1_590_- FIG00000117 19 3 21 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_153988_1_590_+ FIG00001548 12 4 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_153996_1_590_- FIG01307086 76 15 77 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_154007_1_358_- FIG00002968 8 4 9 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_154007_361_590_- FIG00006734 12 3 14 4-amino-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) acetyltrasferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_154011_1_444_+ FIG00012067 109 17 109 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_154034_452_590_+ FIG00001106 26 4 27 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_154076_1_590_+ FIG00000387 120 19 120 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_154084_104_590_+ FIG00001577 118 18 118 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_154085_179_590_+ FIG00047414 5 5 9 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_154114_1_504_+ FIG00000277 53 10 55 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_154116_1_389_- FIG00006128 25 5 27 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_154144_360_589_+ FIG00100439 18 4 18 Translation elongation factor 2 Universal GTPases 2 T2D_unique_154159_1_589_- FIG01304601 157 23 157 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_154172_1_149_- FIG00034973 5 4 6 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_unique_154179_1_589_+ FIG00025216 45 11 53 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_154192_42_589_+ FIG00000145 39 9 41 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_154204_1_589_+ FIG00018699 4 2 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_154206_28_589_- FIG00537822 5 3 6 Heavy-metal-associated domain (N-terminus) and membrane-bounded cytochrome biogenesis cycZ-like domain, possible membrane copper tolerance protein Biogenesis of cbb3-type cytochrome c oxidases 9 T2D_unique_154211_51_563_- FIG00032483 107 17 108 PTS system, fructose- and mannose-inducible IID component (EC 2.7.1.69) Fructose and Mannose Inducible PTS 2 T2D_unique_154215_1_516_- FIG00000504 88 15 89 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_154218_116_589_- FIG01955782 117 19 117 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_154221_197_589_- FIG00000376 20 5 22 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_154225_1_571_- FIG00028203 93 17 94 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_154236_460_589_+ FIG00000141 3 2 4 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_154251_1_579_+ FIG00000207 7 3 8 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_154273_183_589_- FIG00451095 27 8 28 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_154275_1_589_- FIG00001384 132 20 133 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_154288_1_373_+ FIG00066425 36 8 37 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_154302_1_144_+ FIG00006868 24 4 25 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_154312_1_206_- FIG00598409 11 3 12 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_154350_1_589_- FIG00046929 62 14 64 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_154388_85_366_+ FIG00003845 60 9 60 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_154408_242_589_+ FIG00001818 35 9 36 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_154414_1_144_+ FIG00008490 16 3 16 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_154417_156_589_+ FIG00010134 26 7 27 Methionine transporter MetT Methionine Degradation 3 T2D_unique_154426_1_479_+ FIG00000207 134 19 134 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_154432_1_433_+ FIG00000338 13 4 15 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_154433_1_361_- FIG00133325 86 14 86 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_154433_411_589_- FIG00000145 37 6 37 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_154435_1_589_+ FIG00018396 80 16 81 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_154438_1_188_- FIG01290653 37 6 37 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_154476_1_191_+ FIG00000113 28 6 29 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_154481_11_588_+ FIG00000476 29 8 30 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_154493_1_588_+ FIG00132839 111 21 112 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_154507_1_588_+ FIG00130344 73 15 77 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_154509_1_588_+ FIG00000001 6 5 20 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_154551_233_588_+ FIG00014596 5 4 7 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_154562_1_208_- FIG00006678 10 3 11 Nickel transport system permease protein NikC (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_154589_155_484_+ FIG00005243 10 2 11 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_154615_50_588_+ FIG00000582 17 5 19 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_154635_1_354_- FIG01266244 34 6 36 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_154697_251_588_+ FIG00000434 75 12 75 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_154742_1_588_+ FIG00000165 63 16 64 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_154763_1_588_+ FIG00002470 66 13 69 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_154770_287_588_+ FIG00007694 35 6 36 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_154772_1_588_- FIG00000782 44 11 45 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_154786_17_588_+ FIG00002034 142 23 142 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_154788_1_167_+ FIG00136675 12 3 13 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_154827_447_588_+ FIG00031250 31 5 31 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_154840_1_588_+ FIG00140555 150 23 150 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_154846_1_175_+ FIG00001364 38 6 38 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2) Glycine and Serine Utilization 1.12 T2D_unique_154846_198_588_+ FIG00001328 106 16 106 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_unique_154851_1_588_+ FIG00041038 40 11 46 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_154857_412_588_+ FIG00005283 11 3 16 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_154877_1_234_- FIG00002328 24 5 25 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_154879_1_166_- FIG00000948 16 4 18 Poly(A) polymerase (EC 2.7.7.19) Polyadenylation bacterial 2 T2D_unique_154886_1_587_+ FIG00139192 13 8 18 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_154924_1_562_+ FIG00004688 32 6 32 Hypothetical, related to broad specificity phosphatases COG0406 CBSS-196164.1.peg.461 2 T2D_unique_154935_1_171_- FIG00006691 29 5 29 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_154951_1_587_- FIG00002416 158 22 159 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_154985_330_587_- FIG01304636 24 5 25 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_155011_1_187_- FIG01290653 38 6 38 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_155036_1_587_- FIG00134202 39 11 45 Glucan 1,6-alpha-glucosidase (EC 3.2.1.70) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_155044_277_567_+ FIG00000011 8 3 9 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_155045_199_555_- FIG00002412 9 4 12 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_unique_155048_1_587_+ FIG00049336 4 2 5 Foldase protein PrsA precursor (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_155071_1_587_+ FIG00018369 82 16 83 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_155074_1_490_+ FIG00000288 13 5 17 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_155076_1_587_+ FIG00001667 61 10 67 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_155079_1_447_- FIG00136522 115 17 115 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_unique_155095_234_557_+ FIG00000032 4 2 5 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_155100_367_587_- FIG00000892 16 4 18 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_155107_159_587_- FIG00000764 13 4 15 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_155122_415_587_+ FIG00040817 7 3 9 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_155124_1_522_+ FIG00067248 119 20 119 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_155162_1_587_- FIG00026137 45 12 46 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_155165_140_587_- FIG00001269 61 13 62 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_155172_1_340_+ FIG00000252 43 9 44 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_155181_1_587_+ FIG00016514 108 19 109 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_155190_1_203_- FIG00037273 34 5 35 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_unique_155191_1_554_- FIG00000283 136 21 137 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_155210_227_587_- FIG00000288 17 7 19 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_155211_1_587_- FIG00000494 31 7 32 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_155213_1_587_+ FIG00031759 15 4 20 Periplasmic beta-glucosidase (EC 3.2.1.21) Beta-Glucoside Metabolism 2.bc T2D_unique_155253_1_587_- FIG00036320 147 22 148 Alpha-1,4-N-acetylgalactosamine transferase PglJ (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_155276_60_398_+ FIG00045393 9 4 11 Dipeptide transport ATP-binding protein DppF (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_155277_220_582_+ FIG00106663 21 4 22 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_155295_1_586_+ FIG00018865 34 7 36 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_155307_1_586_+ FIG00000269 37 6 39 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_155319_1_586_+ FIG00023004 140 20 140 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_155322_459_586_+ FIG00000445 14 3 14 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_155329_1_165_- FIG00000557 9 3 10 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_155332_244_586_+ FIG00745599 28 6 30 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_155336_1_586_+ FIG00002992 137 20 138 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_155384_1_586_+ FIG00136522 150 23 150 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_unique_155430_1_193_- FIG00000463 7 3 9 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_155454_282_586_+ FIG00005698 33 6 34 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_155463_1_586_+ FIG00000118 136 22 137 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_155475_1_315_- FIG00229257 20 4 21 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_155487_1_586_- FIG00000476 14 6 15 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_155497_1_586_+ FIG00046929 151 24 151 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_155506_220_528_+ FIG00030191 37 5 38 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_155528_1_586_+ FIG00003997 42 10 44 Protein with similarity to RtcB Translation termination factors bacterial 1.13 T2D_unique_155535_1_586_+ FIG00001469 22 8 25 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_155548_1_586_+ FIG00000111 77 13 79 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_155549_1_586_- FIG00002541 156 23 156 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_155550_418_586_- FIG00000683 35 6 35 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Methionine Biosynthesis 8 T2D_unique_155568_1_353_- FIG00000260 50 9 51 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_155569_1_259_+ FIG00000434 71 10 71 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_155596_1_294_+ FIG00000147 11 5 13 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_155603_1_317_- FIG00000128 5 2 7 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_155606_148_543_- FIG00004334 20 4 21 CRISPR-associated protein Cas2 CRISPRs 1 T2D_unique_155628_371_586_- FIG00000494 9 3 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_155660_1_441_+ FIG00846773 65 10 66 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_155667_1_585_+ FIG00000672 5 3 8 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_155670_221_585_+ FIG00000323 4 2 6 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_155674_1_547_+ FIG00000531 59 12 61 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_155695_1_334_- FIG00001583 83 13 83 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_155695_337_585_- FIG00133325 57 10 57 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_155701_161_298_- FIG00001105 28 4 28 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_unique_155709_115_585_- FIG00001656 127 19 127 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_unique_155739_1_585_- FIG01260980 4 4 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_155783_1_585_- FIG00000332 56 14 57 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_155824_66_585_- FIG00133569 27 8 29 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_155829_1_465_+ FIG00020185 91 15 92 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_155847_1_585_+ FIG00000308 47 11 48 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_155871_254_585_- FIG00945384 12 5 13 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_155878_420_585_+ FIG00080955 11 3 13 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_155884_1_143_+ FIG00000584 23 4 23 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_155885_1_338_- FIG00000264 39 8 40 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_unique_155885_382_585_- FIG00000182 19 5 20 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_155891_1_585_- FIG00000474 58 12 60 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_155921_1_353_+ FIG00001882 27 7 27 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_155942_1_585_- FIG00000494 27 9 28 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_155951_1_585_+ FIG00002020 6 3 13 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_155969_1_585_+ FIG00561498 11 3 13 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_155993_1_585_+ FIG00001166 153 23 153 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_156028_1_585_- FIG00001550 23 7 25 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_156044_39_585_- FIG00000858 134 21 134 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_unique_156068_1_584_- FIG00024073 69 15 71 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_156091_1_304_+ FIG00046358 7 3 9 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_156092_1_584_+ FIG00038343 3 3 5 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_156107_242_584_- FIG00047414 5 2 7 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_156108_1_311_- FIG00001932 38 8 39 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_156126_1_584_- FIG00006887 58 11 60 ABC transporter, predicted N-acetylneuraminate-binding protein Sialic Acid Metabolism 1.x T2D_unique_156129_451_584_+ FIG00132839 6 3 7 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_156139_1_408_- FIG00138205 10 3 12 Uptake hydrogenase large subunit (EC 1.12.99.6) Hydrogenases 2 T2D_unique_156154_1_584_- FIG00437351 7 3 9 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_unique_156160_1_345_- FIG00000376 71 11 71 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_156166_1_584_- FIG00016514 22 5 24 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_156189_239_584_- FIG00020897 35 6 36 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_156220_1_385_- FIG00002268 97 14 97 ATP-dependent DNA ligase (EC 6.5.1.1) clustered with Ku protein, LigD DNA Repair Base Excision 4 T2D_unique_156220_415_584_- FIG00001754 42 6 42 Ku domain protein DNA Repair Base Excision 4 T2D_unique_156242_1_584_+ FIG00475203 14 3 15 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_156272_283_584_- FIG00000234 7 3 9 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_156275_149_584_- FIG00002541 25 4 27 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_156334_1_584_- FIG00138960 152 22 152 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_unique_156335_324_584_- FIG00016132 8 2 9 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_unique_156349_1_584_+ FIG00000243 145 22 146 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_156352_1_408_- FIG00846773 91 15 91 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_156363_1_348_+ FIG00846773 7 4 9 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_156372_1_584_+ FIG00136922 140 22 140 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_156390_1_480_+ FIG01955850 41 11 44 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_156396_342_566_+ FIG00002328 17 5 19 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_156419_1_584_+ FIG00000107 118 20 120 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_156424_1_584_- FIG00005992 52 12 54 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_156438_1_584_- FIG00001436 4 2 6 GlpG protein (membrane protein of glp regulon) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_156463_214_584_- FIG00031250 13 5 15 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_156477_1_336_+ FIG00000439 26 6 27 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_156486_1_583_- FIG00001198 5 4 7 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_156487_223_583_+ FIG00229386 44 9 45 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_156515_1_188_- FIG00090765 39 7 39 Lactose and galactose permease, GPH translocator family Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_156520_1_374_+ FIG00080231 9 2 11 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_156520_407_583_+ FIG00001188 35 6 36 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_156524_1_583_- FIG00000279 62 14 63 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_156562_1_398_+ FIG00005283 7 4 8 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_156585_44_583_+ FIG00000614 150 21 150 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_unique_156591_1_276_- FIG00003472 53 8 54 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_156621_207_583_- FIG00001562 11 5 12 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_unique_156633_39_583_- FIG00007960 39 10 40 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_156636_1_418_+ FIG00020626 108 16 109 Leucine dehydrogenase (EC 1.4.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_156674_276_583_- FIG00001547 77 12 77 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_156675_1_583_- FIG00024073 31 6 33 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_156685_1_583_- FIG00016514 31 7 32 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_156688_1_583_- FIG00079988 89 17 90 Copper-translocating P-type ATPase (EC 3.6.3.4) Copper homeostasis 12 T2D_unique_156696_1_583_+ FIG00000210 113 20 113 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_156702_1_528_+ FIG00002020 40 9 60 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_156743_36_257_- FIG00019508 6 4 7 Phage major tail protein Phage tail proteins 2 4 T2D_unique_156746_1_332_- FIG00023943 54 10 55 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_156795_3_583_- FIG00136761 45 10 47 hydantoin racemase Hydantoin metabolism 4 T2D_unique_156801_213_583_- FIG00006463 78 12 78 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_156813_341_583_- FIG00049915 52 9 52 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_156817_1_583_- FIG00000401 48 10 49 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_156818_1_583_- FIG00000111 22 6 23 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_156821_1_583_+ FIG00000877 78 14 79 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_156840_1_487_- FIG00030688 117 18 117 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_156865_86_583_- FIG00000838 50 12 52 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_156894_24_332_- FIG00009564 5 4 7 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_156901_1_485_+ FIG00138258 5 2 7 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_156937_242_582_+ FIG00000241 3 2 7 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_156949_1_582_+ FIG00000139 142 23 142 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_156953_421_582_- FIG00000532 9 2 10 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_156958_1_582_+ FIG01260980 163 23 163 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_156974_1_582_+ FIG00001882 145 21 145 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_156993_1_557_+ FIG00011537 135 20 135 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_156995_193_582_- FIG00003881 12 3 13 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_157004_350_582_- FIG00007586 26 5 27 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_157044_1_582_- FIG00010194 67 11 69 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_157054_1_582_+ FIG00000532 154 23 154 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_157056_1_582_- FIG00022300 149 22 151 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_157066_1_480_- FIG00146073 19 7 20 Legionaminic acid cytidylyltransferase (EC 2.7.7.43) Legionaminic Acid Biosynthesis 1.x T2D_unique_157068_1_371_- FIG00001188 35 9 36 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_157079_167_582_- FIG00000967 30 8 31 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_unique_157087_1_327_- FIG00000112 54 10 55 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_157136_1_582_- FIG00000139 173 24 173 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_157153_1_582_- FIG00847536 103 18 105 Phage (Mu-like) virion morphogenesis protein Phage head and packaging 1 T2D_unique_157163_207_582_+ FIG00000762 21 6 23 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_157189_1_520_- FIG00000897 152 21 152 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_157190_1_400_+ FIG01260980 47 8 48 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_157192_313_582_- FIG00029916 65 10 65 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_157249_1_381_- FIG00071708 28 6 29 CRISPR-associated protein Csm6 CRISPR-associated cluster 1 T2D_unique_157254_1_582_+ FIG00001088 26 6 28 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_157265_1_582_+ FIG00000595 50 11 51 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_157266_116_582_+ FIG00025216 120 18 120 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_157288_1_168_+ FIG00001802 38 6 38 FIG001802: Putative alkaline-shock protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_157288_181_581_+ FIG00042616 21 3 22 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_157303_131_581_+ FIG00000095 71 14 72 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_157327_1_581_- FIG00004220 20 9 22 Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5) Protein degradation 1 T2D_unique_157330_36_581_+ FIG00059211 4 2 6 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_157346_119_496_+ FIG00017761 6 2 7 Biopolymer transport protein ExbD/TolR Ton and Tol transport systems 2 T2D_unique_157390_1_505_+ FIG00034293 4 3 6 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_157442_1_274_+ FIG00099318 56 9 56 RNA polymerase sigma factor SigV Transcription initiation, bacterial sigma factors 1 T2D_unique_157447_1_581_- FIG00475203 5 2 6 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_157466_151_581_- FIG00000206 45 8 46 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_157496_1_192_- FIG00001635 6 2 7 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_157506_1_581_- FIG00001366 33 11 35 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_157527_1_581_+ FIG00066643 41 8 43 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_157536_1_581_- FIG00000065 101 18 102 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_157577_366_581_+ FIG00000863 10 4 11 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_157602_1_390_+ FIG00138182 6 2 8 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_157610_1_571_+ FIG00041038 128 19 129 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_157619_275_581_- FIG01007502 35 8 36 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_157632_442_581_+ FIG00001637 26 4 26 Two-component response regulator SA14-24 Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_157644_231_581_+ FIG00000087 94 14 94 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_157664_1_426_+ FIG00028203 14 5 15 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_157664_436_581_+ FIG00000080 9 2 10 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_157678_1_485_- FIG00002914 39 11 41 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_157681_160_581_+ FIG00058830 52 11 54 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_157706_1_181_- FIG00000449 8 3 9 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_157769_1_350_+ FIG00013638 45 9 47 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_157769_374_580_+ FIG00024851 36 6 38 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_157776_1_251_+ FIG00000118 55 9 55 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_157794_1_377_- FIG00040843 29 7 30 Hexuronate transporter Alginate metabolism 4.xx T2D_unique_157798_1_204_+ FIG00007586 7 3 8 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_157816_1_477_+ FIG00000402 97 16 98 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_157825_1_165_- FIG00001522 13 4 14 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_157888_1_580_- FIG00001548 20 7 22 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_157917_1_580_+ FIG00035175 67 13 68 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_157924_1_383_- FIG00000899 69 12 70 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_157927_1_221_- FIG00000442 6 3 7 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_157937_1_580_- FIG00138538 43 12 44 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_157949_148_459_- FIG00002344 8 4 10 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_157977_1_230_+ FIG00133325 55 9 55 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_158002_260_580_+ FIG00000763 20 4 22 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_158023_112_580_+ FIG00001175 40 8 42 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_158028_1_580_- FIG00000815 139 22 139 Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE Biogenesis of c-type cytochromes 1.1 T2D_unique_158070_1_580_- FIG00003788 40 10 42 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_158098_1_580_- FIG00008294 16 6 18 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_158100_1_580_- FIG00006151 24 9 27 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_158117_284_580_+ FIG00057709 66 10 66 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_158120_198_579_+ FIG00719736 48 10 51 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_158137_1_579_+ FIG00136922 149 23 149 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_158163_381_579_- FIG00561498 14 3 15 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_158183_77_579_+ FIG00001469 9 4 10 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_158204_404_579_+ FIG00000308 11 2 12 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_158215_380_579_+ FIG00043527 16 5 18 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_158219_1_268_- FIG00000710 73 10 73 Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_158219_369_579_- FIG00001440 46 8 46 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_158226_394_579_- FIG00000283 35 7 35 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_158244_1_543_+ FIG00000494 17 5 19 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_158261_1_579_- FIG01260980 131 20 131 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_158288_1_579_+ FIG00008736 131 19 134 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_158298_1_317_- FIG00000212 48 8 49 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_158307_1_579_+ FIG00001088 165 23 165 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_158315_1_470_+ FIG00002304 82 13 88 Putative sugar isomerase involved in processing of exogenous sialic acid Sialic Acid Metabolism 1.x T2D_unique_158326_323_579_+ FIG00000085 9 3 10 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_158334_1_142_+ FIG00000289 10 2 10 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_158341_1_579_+ FIG00000793 46 10 47 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_158350_1_218_+ FIG00093180 5 2 6 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_158428_128_579_- FIG00080955 14 4 16 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_158487_1_485_+ FIG00048507 70 12 71 Catabolite control protein A HPr catabolite repression system 1 T2D_unique_158488_156_579_- FIG00000368 43 10 44 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_158490_1_579_+ FIG00021289 68 13 72 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_158503_1_549_+ FIG00000377 62 13 64 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_158510_51_579_- FIG00085033 23 5 25 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_158546_1_578_+ FIG00000080 159 24 159 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_158548_1_495_- FIG00000522 31 5 36 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_158598_1_578_- FIG00000085 24 6 25 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_158601_1_373_+ FIG00109688 8 3 10 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_158604_368_578_+ FIG00037273 23 3 23 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_unique_158651_1_473_+ FIG00018457 10 4 14 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_158657_1_578_+ FIG00035701 4 4 7 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_158664_1_578_+ FIG00000343 165 23 165 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_158691_1_578_- FIG00132758 154 22 154 Beta-galactosidase large subunit (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_158704_1_265_- FIG00001547 64 9 65 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_158709_1_578_+ FIG00001044 170 23 170 Respiratory nitrate reductase alpha chain (EC 1.7.99.4) Nitrate and nitrite ammonification 1 T2D_unique_158742_1_578_+ FIG00042267 43 11 44 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_158771_1_578_+ FIG00001054 141 22 142 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_158807_1_198_+ FIG00031759 8 2 9 Periplasmic beta-glucosidase (EC 3.2.1.21) Beta-Glucoside Metabolism 2.bc T2D_unique_158820_1_578_+ FIG00016663 55 12 56 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_158834_1_379_+ FIG00000191 43 11 44 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_158876_42_578_+ FIG00038343 4 2 5 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_158909_193_578_+ FIG00000333 64 11 65 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_158925_1_578_+ FIG00071696 5 2 7 ATP-dependent DNA helicase UvrD/PcrA, proteobacterial paralog DNA repair, bacterial UvrD and related helicases 1 T2D_unique_158930_1_578_- FIG00001522 151 23 151 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_158934_362_578_+ FIG01260980 9 2 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_158963_46_578_- FIG00058830 72 12 73 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_158968_1_578_+ FIG01306512 37 9 40 ATP-dependent protease La (EC 3.4.21.53) LonB Type I Proteasome bacterial 1 T2D_unique_158984_1_577_+ FIG00018457 3 3 5 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_158986_59_577_- FIG00042267 15 4 16 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_158990_1_577_- FIG00002992 20 8 27 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_159044_1_545_- FIG00000221 25 7 27 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_159046_1_538_+ FIG00010134 28 8 30 Methionine transporter MetT Methionine Degradation 3 T2D_unique_159092_272_577_- FIG00010738 30 7 31 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_159100_1_577_- FIG00007941 9 4 11 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_159103_1_577_- FIG00000387 49 11 50 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_159107_257_577_+ FIG00017454 41 9 43 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_159115_1_577_+ FIG01260980 19 6 20 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_159127_186_577_+ FIG00132839 18 4 19 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_159160_1_537_+ FIG00229257 10 4 11 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_159161_1_513_+ FIG00077620 82 15 83 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_159168_102_577_+ FIG00048507 97 16 98 Catabolite control protein A HPr catabolite repression system 1 T2D_unique_159171_1_509_+ FIG01954097 73 15 75 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_159176_1_454_+ FIG00000207 128 18 128 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_159219_1_356_- FIG01290653 14 4 15 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_159221_193_577_- FIG00000377 6 2 8 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_159224_1_577_+ FIG00000166 4 7 38 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_159240_269_577_+ FIG00000552 30 6 31 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_159274_60_577_- FIG00002968 17 8 20 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_159294_1_577_+ FIG00060517 18 6 20 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_159310_219_577_+ FIG00007957 16 4 18 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_159332_1_577_- FIG00000782 152 22 152 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_159355_1_241_- FIG00000025 18 4 19 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_159357_1_463_- FIG01955774 5 3 6 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_159358_411_577_+ FIG00000542 28 4 29 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_159377_1_153_- FIG00012531 19 3 20 TRAP-type transport system, small permease component, predicted N-acetylneuraminate transporter Sialic Acid Metabolism 1.x T2D_unique_159377_182_577_- FIG00109897 6 2 8 TRAP-type transport system, periplasmic component, predicted N-acetylneuraminate-binding protein Sialic Acid Metabolism 1.x T2D_unique_159378_1_577_+ FIG00035175 66 11 68 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_159422_1_577_- FIG00075970 133 22 134 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_159431_1_458_+ FIG00000128 49 10 51 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_159432_419_576_+ FIG00092649 12 2 13 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_159463_1_131_+ FIG00000542 5 2 6 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_159503_32_576_- FIG00134060 13 3 15 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_159518_1_381_+ FIG00000578 64 10 65 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_159519_281_576_+ FIG00044622 26 7 27 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_159535_1_429_+ FIG00000892 25 7 26 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_159552_1_576_- FIG00004655 80 11 81 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_159592_191_576_- FIG00051025 4 2 6 Predicted sialic acid transporter Sialic Acid Metabolism 1.x T2D_unique_159595_1_576_+ FIG00044735 174 23 174 Aminopeptidase S (Leu, Val, Phe, Tyr preference) (EC 3.4.11.24) EC 3.4.11.- Aminopeptidases 1 T2D_unique_159610_1_576_+ FIG00000139 28 9 29 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_159650_1_331_+ FIG00001531 11 2 12 D-alanyl transfer protein DltB D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_159653_134_576_+ FIG00034293 34 9 36 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_159668_1_520_+ FIG00000368 53 11 55 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_159671_239_576_- FIG00002049 5 4 7 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_159678_1_576_- FIG00134486 86 18 88 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_159686_200_576_- FIG00000395 18 4 20 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_159697_1_576_- FIG01260980 20 8 22 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_159728_1_278_+ FIG00000775 3 3 4 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_159783_1_264_+ FIG01266244 72 10 72 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_159809_1_367_+ FIG00000298 3 2 7 GTP-binding protein EngB Universal GTPases 2 T2D_unique_159812_1_369_- FIG00044622 98 15 98 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_159889_1_575_+ FIG00001712 140 22 141 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_159915_1_273_+ FIG00000235 13 5 15 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_159943_1_575_- FIG00000303 42 9 44 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_159944_1_575_- FIG00000207 64 13 65 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_159957_1_459_+ FIG01280345 79 14 80 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_159988_12_575_- FIG00000140 20 3 22 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_160020_1_416_- FIG00002022 17 5 19 Nucleotide excision repair protein, with UvrB/UvrC motif Proteolysis in bacteria, ATP-dependent 3 T2D_unique_160031_218_575_- FIG00000126 24 7 27 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_160037_174_575_- FIG00016566 6 3 18 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_160061_1_575_- FIG00012692 159 23 159 Site-specific tyrosine recombinase Proteasome bacterial 1 T2D_unique_160064_1_560_- FIG00000211 35 9 37 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_160069_55_360_- FIG00257451 76 11 77 a forespore shell protein Cell division-ribosomal stress proteins cluster 1 T2D_unique_160069_408_575_- FIG00001497 26 5 27 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Cell division-ribosomal stress proteins cluster 1 T2D_unique_160071_1_575_+ FIG00135554 51 10 53 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_160076_1_575_+ FIG00003174 26 8 28 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_160095_1_440_- FIG00000258 100 17 101 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_160105_1_575_- FIG00000402 45 13 46 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_160125_1_440_+ FIG00000552 32 7 43 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_160149_1_128_+ FIG00001054 15 3 16 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_160157_356_575_- FIG00561498 31 6 31 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_160163_1_203_- FIG00109688 8 2 11 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_160202_1_575_- FIG00031250 34 7 40 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_160208_1_291_+ FIG00084105 43 8 44 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_160228_1_142_+ FIG00000056 5 3 6 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_160230_17_575_- FIG00133515 36 9 37 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_160236_278_575_- FIG00139238 8 4 11 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_160247_25_575_+ FIG00002002 3 4 6 Ascorbate-specific PTS system, EIIC component L-ascorbate utilization (and related gene clusters) 29 T2D_unique_160253_1_303_+ FIG00000107 81 12 81 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_160255_1_575_- FIG00031825 128 20 128 Hydrogen peroxide-inducible genes activator DNA-binding regulatory proteins, strays 1 T2D_unique_160256_124_575_- FIG00000480 20 7 21 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_160261_1_404_+ FIG00000721 22 5 24 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_160306_1_524_+ FIG01260980 15 5 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_160308_1_180_- FIG00007694 11 2 12 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_160317_1_184_+ FIG00000383 35 5 35 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_160317_230_574_+ FIG00001168 41 10 42 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_160357_237_574_+ FIG01010650 90 13 90 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_160390_330_574_- FIG00001067 10 4 11 Rubrerythrin Oxidative stress 1.2 T2D_unique_160406_316_574_- FIG00001522 57 9 58 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_160422_1_574_+ FIG00000118 163 23 163 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_160439_1_574_+ FIG00018536 58 14 60 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_160458_1_574_- FIG00000372 13 6 15 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_160460_1_574_- FIG00002541 104 19 125 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_160467_1_299_- FIG00000040 62 10 62 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_160470_1_303_+ FIG00133229 33 6 34 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_160473_1_574_- FIG00012746 29 7 31 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_160485_1_159_- FIG00085033 4 2 6 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_160485_196_574_- FIG00000221 33 9 34 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_160502_168_574_- FIG00000594 87 15 88 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_160511_54_569_+ FIG00000076 10 5 12 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_160532_1_574_- FIG00060517 8 4 10 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_160544_1_400_+ FIG00002251 54 10 55 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_160547_264_574_+ FIG00057709 6 3 7 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_160555_1_574_+ FIG00007328 3 2 4 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_160556_1_140_- FIG00000263 33 5 33 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_160614_1_574_+ FIG00006463 67 12 68 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_160650_1_574_- FIG00009149 132 22 133 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_160658_1_574_+ FIG00036406 8 3 12 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_160667_1_574_+ FIG00016110 133 21 133 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_160695_1_371_- FIG00000402 18 6 20 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_160695_394_574_+ FIG00047056 6 2 7 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_160702_1_573_+ FIG00093180 20 5 24 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_160713_1_525_+ FIG01343192 9 5 16 Polysaccharide ABC transporter, ATP-binding protein Rhamnose containing glycans 4.1 T2D_unique_160716_1_187_+ FIG00455853 9 4 12 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_160728_1_269_- FIG00000187 4 2 5 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_160739_1_404_- FIG00000081 101 15 102 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_160748_224_573_+ FIG00001547 20 4 21 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_160805_1_563_+ FIG00000990 13 3 14 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_160810_1_573_+ FIG00000672 42 12 43 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_160835_1_573_+ FIG00024930 63 14 65 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_160863_1_198_+ FIG00136193 43 6 43 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_160863_232_573_+ FIG00010818 78 13 78 L-serine dehydratase, beta subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_160900_1_573_+ FIG00001065 42 10 44 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_160920_46_573_- FIG00007495 22 7 24 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_160922_1_573_- FIG00002300 99 18 101 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_160928_131_573_+ FIG00003251 93 17 93 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_161006_84_573_- FIG00002020 86 14 88 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_161007_1_289_+ FIG00026918 4 3 7 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_161025_20_573_- FIG00028203 68 12 69 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_161063_227_573_+ FIG00108342 24 5 25 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_161072_213_573_- FIG00126843 15 3 17 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_161087_1_135_- FIG00062547 7 2 8 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_161114_1_395_- FIG00048014 21 4 22 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_161124_68_573_+ FIG00016663 109 18 110 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_161126_1_213_+ FIG00000474 25 5 26 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_161134_1_573_- FIG00000624 133 20 134 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_161154_1_155_- FIG00006764 11 3 12 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_161163_74_572_+ FIG00000191 107 20 108 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_161197_1_462_+ FIG00093180 5 3 7 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_161206_206_572_+ FIG00016663 77 11 78 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_161207_1_572_+ FIG01260980 7 4 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_161226_180_572_- FIG00064110 20 6 22 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_161232_234_572_+ FIG00133325 12 3 13 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_161268_1_572_- FIG00018865 47 8 48 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_161290_1_460_+ FIG00001547 109 17 111 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_161317_8_572_+ FIG00073301 14 4 16 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_161321_1_325_- FIG00001676 84 12 84 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_161326_1_572_- FIG00000308 10 5 12 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_161337_1_536_+ FIG00021289 12 5 13 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_161339_246_572_+ FIG00000387 23 7 24 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_161351_16_288_- FIG00018699 8 4 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_161357_1_572_- FIG01266244 16 7 20 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_161384_1_398_- FIG00000036 102 16 102 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_161477_12_572_+ FIG00000539 88 15 90 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_161478_417_572_+ FIG00007714 27 5 27 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_161539_1_397_+ FIG00030006 94 14 95 ATP-dependent DNA helicase SCO5183 DNA repair, bacterial RecBCD pathway 3 T2D_unique_161546_1_572_- FIG00000134 39 11 41 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_161551_1_128_+ FIG00016265 19 3 19 Carboxynorspermidine dehydrogenase, putative (EC 1.1.1.-) Polyamine Metabolism 2 T2D_unique_161558_1_526_+ FIG00945384 37 10 39 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_161574_1_571_- FIG00003433 34 10 36 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_161583_1_384_- FIG00003394 107 15 107 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_161604_123_571_- FIG00024851 115 16 115 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_161638_48_197_- FIG00001269 3 2 4 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_161645_1_382_+ FIG01292786 7 3 9 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_161645_407_571_+ FIG00013534 30 6 31 Substrate-specific component BL0695 of predicted ECF transporter ECF class transporters 345678 T2D_unique_161666_432_571_- FIG00000704 32 5 32 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_161672_1_130_+ FIG00001548 31 5 31 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_161675_1_571_+ FIG00002344 16 6 17 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_161680_1_571_- FIG00000336 47 11 48 Cytosol aminopeptidase PepA (EC 3.4.11.1) EC 3.4.11.- Aminopeptidases 1 T2D_unique_161688_1_571_- FIG00059211 18 6 20 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_161707_1_571_+ FIG01955902 6 2 8 Rubredoxin Rubrerythrin 2 T2D_unique_161720_226_571_- FIG00000210 81 13 81 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_161729_1_571_- FIG00000504 60 10 62 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_161775_218_571_+ FIG00000449 28 6 29 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_161778_1_258_- FIG00001469 9 2 10 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_161780_323_571_+ FIG00008411 39 8 40 DNA polymerase III epsilon subunit (EC 2.7.7.7) CBSS-228410.1.peg.134 1.x T2D_unique_161799_1_571_+ FIG00002541 96 18 97 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_161816_406_571_+ FIG00000280 31 6 32 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_161826_1_571_- FIG00003715 5 2 7 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_161837_396_571_- FIG00000325 39 6 39 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_161841_1_571_+ FIG00340292 3 2 5 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_161873_1_571_- FIG00006151 124 20 124 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_161910_1_465_+ FIG00001547 119 18 120 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_161915_1_571_- FIG01228918 6 3 9 ErfK/YbiS/YcfS/YnhG family protein Copper homeostasis 12 T2D_unique_161938_1_279_+ FIG00000101 9 2 11 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_161954_1_571_+ FIG01955782 80 15 81 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_161955_1_555_+ FIG00000095 66 14 67 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_161970_1_293_- FIG00000899 12 3 14 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_161971_1_571_+ FIG00003251 35 7 36 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_161980_347_508_- FIG01955902 33 5 33 Rubredoxin Rubrerythrin 2 T2D_unique_161988_1_571_+ FIG00059211 125 18 126 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_162018_1_213_+ FIG00001548 7 3 8 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_162025_1_570_- FIG00140898 143 20 143 periplasmic fructose-binding protein component of signal transduction system LevT Fructose and Mannose Inducible PTS 2 T2D_unique_162030_1_570_- FIG00028461 31 5 32 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_162057_1_570_- FIG00000146 108 18 109 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_162088_1_453_+ FIG00000738 6 10 61 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_162145_1_570_+ FIG00003520 40 8 42 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_162202_304_570_- FIG00000355 61 10 61 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_162219_1_140_- FIG00000317 13 3 14 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_162219_182_570_- FIG00000075 15 4 16 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_162229_1_570_- FIG00003086 34 9 35 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_162260_256_570_- FIG00058998 4 2 5 Vancomycin response regulator VanR Resistance to Vancomycin X T2D_unique_162263_1_431_- FIG00001253 3 2 4 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_162265_33_570_+ FIG00003520 6 4 8 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_162324_191_421_+ FIG00006970 14 3 15 Nickel transport system permease protein NikB (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_162331_1_506_+ FIG00000155 24 8 25 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_162359_49_570_- FIG00003460 16 6 18 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_162392_1_570_+ FIG00000520 143 20 144 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_162425_1_302_- FIG00041164 22 5 25 Additional substrate-specific component CbiN of cobalt ECF transporter ECF class transporters 345678 T2D_unique_162429_1_570_- FIG00001932 19 5 21 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_162442_332_570_+ FIG00000151 53 8 53 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_162455_1_242_+ FIG00013339 6 3 10 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_162455_313_570_+ FIG00127025 7 3 8 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_162456_52_570_- FIG00001134 141 20 141 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_unique_162471_1_570_+ FIG00063189 34 14 77 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_162475_1_177_+ FIG00000298 9 2 10 GTP-binding protein EngB Universal GTPases 2 T2D_unique_162478_327_570_- FIG00846773 18 3 19 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_162506_1_315_+ FIG00000422 75 11 75 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_162518_1_569_- FIG00008285 26 8 29 Ribose ABC transporter, periplasmic ribose-binding protein RbsB (TC 3.A.1.2.1) Bacterial Chemotaxis 9 T2D_unique_162541_415_569_+ FIG00008736 5 2 6 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_162547_1_569_- FIG00000505 52 11 54 ATP-dependent hsl protease ATP-binding subunit HslU Proteasome bacterial 1 T2D_unique_162569_1_569_- FIG00002847 144 21 145 HflK protein Hfl operon 1.111 T2D_unique_162571_1_569_- FIG00006351 71 12 73 ABC transporter, predicted N-acetylneuraminate transport system permease protein 1 Sialic Acid Metabolism 1.x T2D_unique_162585_269_569_- FIG00002020 83 12 83 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_162600_1_569_+ FIG00001548 151 21 152 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_162621_1_422_+ FIG00000087 20 7 22 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_162623_1_213_- FIG00079822 12 3 13 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_162644_1_569_- FIG00028203 41 11 43 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_162645_1_569_- FIG00001120 149 22 149 Isopentenyl-diphosphate delta-isomerase, FMN-dependent (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_162649_1_569_- FIG00052802 158 23 158 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_unique_162659_60_371_- FIG00001021 7 4 10 Integration host factor beta subunit DNA structural proteins, bacterial 1.1100 T2D_unique_162680_1_569_- FIG00018396 4 3 6 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_162696_1_554_- FIG00000459 134 21 135 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_162716_1_569_+ FIG00140555 133 21 133 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_162772_31_569_+ FIG00003299 21 8 29 L-arabinose-binding periplasmic protein precursor AraF (TC 3.A.1.2.2) L-Arabinose utilization 1 T2D_unique_162789_1_464_+ FIG00006151 13 2 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_162792_277_569_+ FIG01239241 16 4 24 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_162794_318_569_- FIG00000001 7 4 9 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_162798_1_569_+ FIG00003788 15 6 19 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_162807_1_569_+ FIG00001022 7 5 14 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_162828_1_569_- FIG00041038 19 7 21 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_162840_44_569_- FIG00133515 134 20 134 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_162841_1_569_- FIG00004688 81 13 82 Hypothetical, related to broad specificity phosphatases COG0406 CBSS-196164.1.peg.461 2 T2D_unique_162859_52_569_+ FIG00000252 6 2 8 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_162892_1_569_- FIG01304530 11 3 12 Phage terminase, large subunit Phage head and packaging 1 T2D_unique_162933_167_568_- FIG00004170 21 6 22 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_162939_121_568_+ FIG00034392 26 7 27 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_162944_1_568_+ FIG00000080 14 5 16 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_162957_1_411_+ FIG00002489 3 3 5 Spore germination protein GerKA Spore germination 1 T2D_unique_162960_1_568_- FIG00042267 6 4 7 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_162963_1_243_+ FIG00000145 9 3 11 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_162976_1_568_+ FIG00138258 12 5 14 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_163001_1_541_- FIG00018224 116 18 117 Substrate-specific component MtsA of methionine-regulated ECF transporter ECF class transporters 345678 T2D_unique_163053_1_568_- FIG00008490 4 4 10 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_163088_321_568_- FIG00125395 73 10 73 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_163102_1_568_- FIG00168885 5 2 7 Cellobiose phosphorylase (EC 2.4.1.-) Beta-Glucoside Metabolism 2.bc T2D_unique_163122_357_568_+ FIG00006997 13 3 14 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_163143_1_568_+ FIG00000097 15 3 16 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_163164_1_568_+ FIG00093180 165 22 165 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_163169_1_568_+ FIG00000056 69 15 70 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_163175_1_568_+ FIG00010454 116 20 117 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_163176_1_356_- FIG00126843 92 14 92 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_163178_1_568_- FIG00000040 27 9 48 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_163179_1_568_- FIG00026137 32 8 34 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_163188_146_568_+ FIG00046929 3 2 4 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_163207_1_568_+ FIG00719736 37 10 38 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_163224_1_366_+ FIG00000145 29 6 30 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_163226_1_538_+ FIG00050603 14 10 24 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_163229_1_568_+ FIG00028203 128 20 128 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_163231_1_568_+ FIG00005728 8 5 11 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_163234_1_568_- FIG00000542 127 20 127 Ribonuclease HI (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_163244_139_568_+ FIG01176807 52 10 53 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_163245_1_568_- FIG00007658 134 22 134 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_163294_266_568_- FIG00004453 16 4 17 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_163306_1_332_- FIG00037431 67 12 68 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_163327_1_568_+ FIG00014764 8 4 11 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_163349_188_567_- FIG00003076 5 3 7 Lactam utilization protein LamB EC699-706 1 T2D_unique_163363_1_567_- FIG00000402 15 5 18 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_163367_1_293_+ FIG00004743 76 11 76 Lactoylglutathione lyase (EC 4.4.1.5) Methylglyoxal Metabolism 3.x T2D_unique_163408_97_567_+ FIG00004502 4 3 7 5'-nucleotidase YjjG (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_163425_1_567_- FIG00024851 30 6 31 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_163428_1_567_- FIG01304601 10 3 13 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_163442_1_567_+ FIG00000422 47 10 49 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_163455_389_567_+ FIG00000095 17 3 18 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_163456_286_567_+ FIG00745599 12 3 13 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_163468_289_567_+ FIG00058830 44 8 45 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_163504_1_428_+ FIG00007495 8 3 11 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_163520_1_567_+ FIG01304461 26 6 30 Putative sugar ABC transport system, permease protein YtfT Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_163521_1_567_+ FIG00001088 46 9 47 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_163535_125_567_+ FIG00001119 15 4 17 Glycerol-3-phosphate regulon repressor, DeoR family Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_163562_1_567_- FIG00002070 156 23 156 Arabinose-proton symporter L-Arabinose utilization 1 T2D_unique_163564_256_567_+ FIG00000962 7 3 9 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_163586_173_567_- FIG00043476 7 2 9 preQ1-regulated inosine-uridine nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_163591_1_567_- FIG00001548 141 20 142 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_163594_1_322_+ FIG00073301 7 4 8 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_163610_1_567_- FIG00000130 52 14 54 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_163611_1_390_+ FIG00000190 79 13 80 Recombination protein RecR DNA processing cluster 1.1 T2D_unique_163611_407_567_+ FIG00000877 29 5 30 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_163624_1_567_- FIG00016566 29 11 36 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_163629_262_567_+ FIG00000979 27 7 28 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_unique_163640_301_567_+ FIG00000075 5 2 6 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_163646_1_567_+ FIG00057709 23 5 30 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_163669_103_567_- FIG00002239 121 18 121 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_163673_1_219_+ FIG00016836 13 4 15 Transcription termination protein NusB Transcription factors bacterial 1 T2D_unique_163687_1_567_- FIG00000114 119 18 120 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_163688_1_567_- FIG00000395 151 22 151 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_163698_76_567_- FIG00126843 39 9 40 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_163703_1_435_+ FIG00000116 66 12 67 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_163712_1_567_- FIG00139192 33 11 34 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_163746_1_567_+ FIG00000001 38 9 40 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_163772_1_567_+ FIG00001067 10 3 13 Rubrerythrin Oxidative stress 1.2 T2D_unique_163781_106_567_- FIG00019415 95 16 96 Putative activity regulator of membrane protease YbbK CBSS-316057.3.peg.659 1 T2D_unique_163790_36_567_+ FIG00016663 17 4 19 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_163827_1_566_- FIG00000482 54 12 56 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_163842_1_320_- FIG00001522 26 5 27 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_163899_1_496_- FIG00003251 55 13 58 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_163917_70_566_- FIG00018369 43 9 45 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_163918_272_517_+ FIG00002328 12 4 13 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_163948_304_525_+ FIG00008708 6 2 7 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_163949_1_516_- FIG00012945 80 12 81 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_163958_1_566_+ FIG00001522 154 22 154 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_164036_1_412_- FIG00000338 64 14 65 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_164045_20_566_- FIG00019868 68 14 87 Maltose/maltodextrin ABC transporter, permease protein MalF Maltose and Maltodextrin Utilization 1.x T2D_unique_164069_1_566_- FIG00016663 134 22 135 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_164088_1_462_+ FIG00011537 18 6 20 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_164100_1_566_- FIG00006167 130 21 130 Clostridial MutS2-related protein DNA repair, bacterial MutL-MutS system 1 T2D_unique_164122_1_566_- FIG00010600 29 6 30 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_164126_1_305_+ FIG00009682 8 3 9 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_164130_433_566_+ FIG00048014 14 3 14 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_164145_1_566_- FIG00018561 22 7 28 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_164163_1_566_+ FIG00000575 29 9 33 L-aspartate oxidase (EC 1.4.3.16) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_164166_86_566_- FIG00028694 10 6 13 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_164168_165_566_- FIG00017518 3 2 5 Alpha-L-arabinofuranosidase II precursor (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_164176_1_566_+ FIG00000139 47 12 48 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_164196_1_566_+ FIG00006764 90 14 101 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_164219_1_566_- FIG00000102 14 4 16 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_164266_1_565_- FIG00000317 112 19 113 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_164270_1_565_- FIG00000101 108 20 109 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_164285_283_565_- FIG00007957 9 2 10 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_164299_208_565_- FIG00001402 71 13 71 Helicase loader DnaI DNA-replication 4 T2D_unique_164355_66_565_+ FIG00003844 38 8 39 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_164382_1_565_- FIG00451095 12 6 14 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_164391_1_200_- FIG00000636 16 4 17 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_164406_1_565_- FIG00000372 28 8 30 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_164409_223_565_+ FIG00000089 24 9 26 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_164422_1_565_- FIG00134486 83 15 86 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_164428_354_565_+ FIG00000695 51 8 51 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_164429_1_315_+ FIG00007694 8 5 10 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_164446_1_305_+ FIG00000328 27 7 28 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_164451_1_565_- FIG00001548 5 3 6 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_164453_1_565_- FIG00041382 31 7 34 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_164455_1_446_- FIG00009956 25 9 27 RNA:NAD 2'-phosphotransferase tRNA splicing 1 T2D_unique_164479_1_565_+ FIG00011468 125 22 127 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_164501_1_565_- FIG00561498 74 12 75 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_164502_145_565_- FIG00059124 27 6 28 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_164508_379_565_+ FIG00003076 26 5 27 Lactam utilization protein LamB EC699-706 1 T2D_unique_164511_1_565_+ FIG00012746 68 12 75 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_164516_240_565_+ FIG00000185 36 9 38 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_164526_1_565_+ FIG01260980 28 8 31 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_164568_1_565_+ FIG00010134 59 12 61 Methionine transporter MetT Methionine Degradation 3 T2D_unique_164600_144_565_- FIG00000439 4 5 5 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_164605_1_565_+ FIG00043527 11 5 13 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_164609_1_565_+ FIG00093180 15 8 17 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_164627_366_565_+ FIG00001237 3 2 4 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_164646_413_565_- FIG00001865 31 5 32 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_164661_1_565_- FIG00000401 43 10 44 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_164668_1_564_+ FIG00000308 28 8 30 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_164672_1_564_+ FIG01271998 45 13 47 Possible hypoxanthine oxidase XdhD (EC 1.-.-.-) Purine conversions 4.1118100 T2D_unique_164698_1_564_- FIG00000449 141 21 141 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_164701_1_524_- FIG00010771 9 8 19 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_164709_1_564_- FIG00049915 31 8 33 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_164768_1_564_- FIG00000156 100 17 102 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_164770_1_564_- FIG00000155 7 2 9 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_164789_326_564_+ FIG00138018 11 4 12 Alpha-glucosidase SusB (EC 3.2.1.20) Cellulosome 1.x T2D_unique_164796_1_564_- FIG00001548 38 11 43 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_164800_1_466_+ FIG00016566 119 18 119 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_164845_341_564_+ FIG00000721 25 5 25 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_164849_1_564_- FIG00000212 23 10 33 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_164864_1_564_+ FIG00044622 86 15 87 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_164869_1_491_+ FIG00010738 22 6 24 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_164871_393_564_+ FIG00012945 11 3 12 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_164889_1_564_+ FIG00093180 143 22 144 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_164905_380_564_+ FIG00000208 13 4 14 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_164909_310_507_+ FIG00133229 11 3 12 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_164939_1_138_+ FIG00006868 14 3 15 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_164948_100_564_+ FIG00001670 119 18 119 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_164960_1_182_- FIG00000402 3 2 4 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_164978_1_564_- FIG00126843 105 19 107 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_164982_9_564_- FIG00116638 72 15 73 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_165004_193_447_- FIG00005308 12 3 13 Catabolite repression HPr-like protein Crh HPr catabolite repression system 1 T2D_unique_165017_436_564_+ FIG00000085 13 3 14 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_165025_37_564_- FIG00000477 54 10 55 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_165026_1_359_+ FIG00001616 103 14 103 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_165028_64_504_- FIG01361711 22 5 25 Hypothetical N-acetyltransferase Cobalt-zinc-cadmium resistance 1.26 T2D_unique_165042_1_382_+ FIG00000097 23 5 25 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_165070_1_155_+ FIG00011114 26 5 27 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_165073_1_564_+ FIG00009450 104 16 107 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_165087_1_281_- FIG00012067 53 8 53 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_165127_239_563_- FIG00129130 27 7 30 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_165166_1_563_+ FIG01260980 17 10 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_165186_1_563_+ FIG00561498 52 11 53 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_165209_1_563_- FIG00000402 67 14 69 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_165232_251_409_- FIG00012547 10 2 12 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) Biotin biosynthesis 1X T2D_unique_165237_1_276_- FIG00010844 4 2 6 Flavodoxin Flavodoxin 1 T2D_unique_165257_1_563_+ FIG00846773 85 15 96 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_165259_131_563_+ FIG00451095 49 11 50 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_165298_1_472_+ FIG00049915 52 10 54 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_165309_158_563_+ FIG00002588 6 4 7 Formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) One-carbon metabolism by tetrahydropterines 5 T2D_unique_165313_1_563_+ FIG01260980 60 13 61 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_165315_1_334_- FIG00000476 81 12 81 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_165333_1_525_+ FIG00000402 35 7 37 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_165340_307_563_- FIG00000001 6 2 7 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_165346_1_563_+ FIG00018699 77 13 79 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_165353_1_459_- FIG00011659 26 7 28 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_165380_1_563_+ FIG00000793 36 9 38 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_165427_1_563_+ FIG00001354 16 5 18 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_unique_165445_1_395_- FIG01318398 9 2 10 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_165463_1_563_- FIG01260980 15 4 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_165473_1_563_- FIG00000242 61 13 63 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_165480_398_563_+ FIG00134167 14 3 15 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_165539_1_280_+ FIG00000343 10 3 12 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_165544_412_562_+ FIG00007957 11 3 13 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_165557_165_562_+ FIG00054459 103 16 103 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_165561_1_309_+ FIG00007997 33 7 35 Beta-lactamase repressor BlaI Beta-lactamase 1 T2D_unique_165565_20_562_- FIG00002354 41 10 42 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_165569_1_562_+ FIG00024930 117 18 119 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_165580_1_562_- FIG00000176 30 5 32 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_165588_1_162_+ FIG00134342 14 5 15 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_165595_234_562_+ FIG00000899 46 8 49 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_165630_1_562_+ FIG00000055 53 12 55 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_165634_178_562_- FIG00028476 78 14 78 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_165648_1_488_+ FIG00000131 113 18 114 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_165654_1_402_+ FIG00001687 16 4 17 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_165695_1_259_+ FIG00000287 38 6 39 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_165712_1_562_- FIG00028694 45 12 47 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_165782_1_546_- FIG00094401 28 7 29 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_165876_1_538_- FIG00074225 5 5 6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_165893_1_562_+ FIG00138182 51 10 52 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_165902_1_562_+ FIG00000047 106 18 107 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_165917_1_562_- FIG00000343 31 13 94 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_165993_1_534_+ FIG00000134 16 4 18 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_165994_1_552_- FIG00000165 121 21 121 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_166039_1_561_+ FIG00034392 42 14 43 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_166055_1_561_+ FIG00010771 106 17 106 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_166071_1_561_- FIG00000069 14 6 16 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_166075_1_561_+ FIG00000402 41 9 43 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_166131_1_134_- FIG00007957 4 2 5 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_166140_1_451_+ FIG00000263 30 9 32 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_166158_179_561_- FIG00096593 6 3 7 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_166171_1_561_+ FIG00063189 81 15 82 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_166190_1_561_- FIG00075702 19 4 21 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_166202_1_186_- FIG00000028 41 6 41 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_166227_1_561_+ FIG00000659 108 19 109 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_166328_1_561_+ FIG00011468 36 11 38 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_166338_6_272_+ FIG00104848 9 2 10 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_166354_1_561_- FIG00109688 33 10 34 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_166358_1_296_- FIG00002803 44 7 45 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_166358_298_561_- FIG00000401 62 10 62 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_166370_1_235_+ FIG00018699 13 3 14 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_166383_1_354_- FIG00001020 39 8 40 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_166417_1_552_+ FIG00000370 126 20 127 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_166425_1_561_+ FIG00004078 7 3 10 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_166427_1_561_+ FIG00049915 40 12 42 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_166433_1_427_+ FIG00003435 10 4 11 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_166470_1_561_- FIG00013638 42 10 44 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_166477_1_561_- FIG00006691 136 21 137 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_166478_1_411_+ FIG01954097 4 4 8 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_166518_87_560_- FIG00000402 19 5 20 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_166519_43_560_- FIG00000842 115 18 115 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_166522_1_497_+ FIG00000098 5 3 6 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_166528_1_560_- FIG00022976 21 7 22 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_166552_1_560_+ FIG00229386 15 6 17 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_166553_1_226_- FIG00003012 16 4 16 His repressor CBSS-393121.3.peg.1913 1 T2D_unique_166559_214_560_+ FIG00000539 24 5 26 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_166560_157_560_+ FIG00001080 51 9 52 Membrane fusion component of tripartite multidrug resistance system Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 1 T2D_unique_166597_1_560_+ FIG00000387 116 20 118 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_166603_1_560_- FIG00001065 9 3 10 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_166616_322_560_- FIG00000032 17 5 19 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_166620_1_560_- FIG00034293 32 9 44 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_166631_1_406_- FIG00008879 5 3 7 Heme transporter IsdDEF, lipoprotein IsdE Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_166647_1_560_+ FIG00059211 26 7 27 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_166649_373_560_+ FIG01304430 20 4 20 putative ATP-dependent DNA helicase YjcD DNA repair, bacterial UvrD and related helicases 1 T2D_unique_166659_401_560_- FIG00001676 14 5 16 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_166661_1_560_- FIG00028203 144 21 144 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_166681_1_164_- FIG00000402 29 4 30 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_166697_1_224_+ FIG00000290 12 4 14 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_166712_103_546_+ FIG00008273 66 14 67 N-acetylneuraminate synthase (EC 2.5.1.56) Sialic Acid Metabolism 1.x T2D_unique_166733_1_560_+ FIG00080955 22 7 23 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_166739_1_560_+ FIG00001469 44 11 45 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_166742_1_560_- FIG00022445 147 21 148 Regulation of D-alanyl-lipoteichoic acid biosynthesis, sensor histidine kinase Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_166751_1_560_- FIG00134486 50 12 51 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_166804_229_459_+ FIG00117785 54 8 54 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_unique_166816_1_560_- FIG00000606 144 22 144 Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_166823_1_560_- FIG00001042 19 5 22 Urease beta subunit (EC 3.5.1.5) Urease subunits 1.x T2D_unique_166831_1_321_- FIG00000584 24 5 25 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_166882_1_560_+ FIG00000474 68 15 70 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_166890_1_300_- FIG00064110 26 7 27 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_166903_1_290_+ FIG00000131 28 6 30 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_166903_345_545_+ FIG00000394 16 3 17 DNA-directed RNA polymerase omega subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_166917_1_278_+ FIG00088996 56 9 56 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_unique_166927_1_560_+ FIG00002492 24 6 28 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (EC 6.3.2.-) Peptidoglycan biosynthesis--gjo 1 T2D_unique_166937_183_560_- FIG00000070 65 11 66 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_166942_1_242_+ FIG00000151 66 9 66 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_166944_1_560_+ FIG00000025 131 21 131 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_166948_67_560_- FIG00010675 118 18 119 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_unique_166964_1_559_- FIG00029916 144 22 144 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_167006_1_559_+ FIG00000111 67 15 68 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_167009_1_559_+ FIG00000372 100 15 101 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_167016_241_559_- FIG00000315 5 4 6 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_167042_1_559_- FIG00024226 5 4 9 Ribose operon repressor D-ribose utilization A.123 T2D_unique_167078_1_454_+ FIG00049433 7 4 8 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_167126_117_559_+ FIG00007514 3 3 4 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_167140_1_559_+ FIG00001675 21 8 22 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_167149_1_289_- FIG00052605 75 11 75 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_167150_423_559_+ FIG00000372 17 3 18 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_167172_262_559_- FIG00026918 31 7 32 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_167181_1_371_- FIG00001067 32 8 34 Rubrerythrin Oxidative stress 1.2 T2D_unique_167194_1_559_+ FIG00711303 125 22 125 Guanine-hypoxanthine permease Purine Utilization 1 T2D_unique_167198_1_559_+ FIG00000445 24 7 25 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_167247_1_169_- FIG00018457 3 2 5 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_167247_208_559_- FIG00007079 11 2 12 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_167265_1_559_- FIG00001635 38 6 41 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_167272_44_559_+ FIG00031250 8 6 11 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_167284_1_559_- FIG00135469 54 11 57 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_167287_78_559_+ FIG00000290 25 7 28 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_167288_229_559_+ FIG00000315 12 4 14 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_167323_273_559_+ FIG00001120 67 10 67 Isopentenyl-diphosphate delta-isomerase, FMN-dependent (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_167355_190_384_+ FIG00001712 8 3 10 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_167362_159_359_- FIG00002504 11 3 13 DNA-damage-inducible protein J Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_167385_1_146_+ FIG00000185 12 3 13 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_167407_1_559_- FIG01260980 27 7 28 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_167422_1_558_- FIG00000494 10 5 12 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_167423_1_558_+ FIG00030191 15 7 16 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_167435_1_558_+ FIG00023369 108 18 109 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_167458_1_558_+ FIG00132967 4 2 5 Iron(III) dicitrate transport ATP-binding protein FecE (TC 3.A.1.14.1) Flavohaemoglobin 1 T2D_unique_167469_1_558_- FIG00001712 28 8 31 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_167476_1_558_+ FIG00021289 4 2 6 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_167500_1_558_+ FIG00000365 63 14 65 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_167537_281_558_+ FIG00132630 8 5 10 Ferric uptake regulation protein FUR Oxidative stress 1.2 T2D_unique_167573_209_558_+ FIG00455853 11 4 13 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_167585_41_558_- FIG00001036 48 10 51 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_167605_1_335_- FIG00846773 3 2 5 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_167606_1_188_- FIG00001548 4 2 5 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_167618_403_558_- FIG00016132 30 5 31 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_unique_167643_1_558_+ FIG00006151 3 2 5 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_167648_1_558_+ FIG00002130 161 23 161 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_167726_1_515_+ FIG00000080 52 11 54 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_167730_1_558_+ FIG01260980 14 7 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_167738_1_444_+ FIG00000011 57 13 58 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_167759_1_558_+ FIG00451095 9 2 11 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_167774_1_558_+ FIG00001548 32 7 33 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_167787_1_509_- FIG00000986 56 13 57 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_167788_1_558_- FIG01304636 16 7 19 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_167814_1_558_+ FIG00000234 120 20 121 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_167829_1_472_- FIG00000146 51 9 52 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_167835_1_558_- FIG00004078 22 7 25 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_167861_1_558_+ FIG00035175 16 5 19 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_167882_1_516_+ FIG00005243 7 4 8 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_167895_6_242_- FIG00000256 7 3 8 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_167898_1_557_+ FIG00001548 12 6 17 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_167899_1_557_+ FIG00009210 62 12 64 FIG009210: peptidase, M16 family CBSS-257314.1.peg.676 4.x T2D_unique_167903_1_431_+ FIG00001469 18 4 19 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_167937_1_557_+ FIG00016514 36 9 37 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_167941_123_557_- FIG00000401 14 2 15 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_167947_310_557_+ FIG00000056 12 4 23 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_167959_272_557_+ FIG00071623 69 10 69 Naphthoate synthase (EC 4.1.3.36) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_167962_1_476_- FIG00001818 49 13 52 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_167967_80_557_+ FIG00050243 3 3 11 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_167977_1_508_+ FIG00036983 26 8 29 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_168006_62_557_- FIG00029868 40 6 42 Epi-inositol hydrolase (EC 3.7.1.-) Inositol catabolism 5.x T2D_unique_168026_416_557_+ FIG00451095 30 5 30 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_168031_1_154_+ FIG00000897 12 3 14 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_168051_238_557_+ FIG00000370 6 3 8 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_168059_1_511_- FIG00000065 150 20 150 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_168063_1_557_- FIG00000208 118 18 119 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_168085_1_557_- FIG00136692 48 11 56 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_168095_1_557_+ FIG00034392 33 5 35 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_168099_1_382_- FIG00001798 97 14 98 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_168107_142_557_+ FIG00000494 17 4 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_168115_1_471_+ FIG00029916 79 12 80 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_168125_1_557_- FIG00000145 17 4 18 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_168135_1_557_- FIG00001547 16 5 17 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_168146_1_279_- FIG00002504 57 10 57 DNA-damage-inducible protein J Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_168206_316_557_- FIG00055520 7 3 9 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_168207_1_557_+ FIG00000147 44 14 46 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_168208_1_557_+ FIG00004655 54 9 58 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_168218_1_557_- FIG00003086 80 16 81 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_168246_100_557_+ FIG00010760 7 2 9 Sensor histidine kinase colocalized with HrtAB transporter Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_168249_1_557_+ FIG00019251 43 10 45 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_168250_1_557_- FIG00016663 120 20 120 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_168262_330_557_- FIG00002716 16 4 17 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_168265_1_557_+ FIG00000241 11 7 26 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_168335_1_557_- FIG00005727 20 6 21 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_168342_1_471_- FIG00846773 24 6 27 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_168386_1_556_- FIG00763261 55 14 89 DNA replication protein DnaC DNA-replication 4 T2D_unique_168393_1_556_- FIG01956048 10 6 23 Hypothetical oxidoreductase YqhD (EC 1.1.-.-) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_168401_101_301_+ FIG00059211 7 2 8 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_168411_1_556_- FIG00003174 21 6 24 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_168425_1_450_+ FIG00000437 56 11 69 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_168429_336_556_+ FIG00000273 9 3 10 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_unique_168445_1_556_- FIG00002020 28 7 29 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_168457_1_556_- FIG00035934 123 20 123 Ferric enterobactin-binding periplasmic protein FepB (TC 3.A.1.14.2) Siderophore Enterobactin 8 T2D_unique_168476_1_556_+ FIG00041038 25 7 27 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_168477_1_545_+ FIG00000088 28 7 30 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_168494_44_292_- FIG00002020 67 10 67 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_168515_1_189_+ FIG00001280 44 7 44 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_168522_1_190_+ FIG00051882 22 5 23 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Cobalamin synthesis 2 T2D_unique_168545_1_556_+ FIG00044478 20 8 22 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_168554_1_556_- FIG00036983 32 9 33 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_168613_1_556_- FIG00011537 13 4 15 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_168627_1_556_- FIG00002273 112 19 113 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_168635_1_556_- FIG00000187 13 3 15 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_168653_1_272_+ FIG00001980 7 3 8 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_168654_1_380_+ FIG00026137 40 10 41 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_168662_307_556_- FIG00000464 46 7 46 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_168687_1_233_- FIG00000402 31 7 32 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_168700_1_490_+ FIG00002541 11 3 14 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_168710_256_556_+ FIG00000367 22 7 24 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_168714_1_556_- FIG00010194 7 4 9 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_168717_107_556_- FIG00000494 8 2 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_168723_40_556_+ FIG00081563 109 18 110 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_168756_1_556_+ FIG00003756 101 19 118 Maltose-6'-phosphate glucosidase (EC 3.2.1.122) Maltose and Maltodextrin Utilization 1.x T2D_unique_168791_14_556_- FIG00010600 129 20 130 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_168815_145_556_+ FIG00008907 4 4 7 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_168847_1_556_- FIG00132617 9 8 35 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_168876_1_555_- FIG00011537 17 5 19 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_168900_1_555_- FIG00000717 35 8 39 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_168904_351_555_- FIG01260980 5 2 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_168936_239_555_+ FIG00008490 41 8 43 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_168963_1_555_+ FIG00000333 79 15 81 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_169009_1_555_- FIG00000242 11 6 16 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_169011_1_555_+ FIG00028203 62 13 78 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_169022_1_555_- FIG00079822 39 11 40 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_169025_1_555_+ FIG00011659 124 19 125 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_169035_331_555_- FIG00130344 19 5 23 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_169060_1_555_+ FIG00132617 5 2 7 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_169078_1_277_+ FIG00041038 6 3 8 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_169083_1_555_- FIG00002130 160 22 160 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_169107_403_555_+ FIG00001133 19 4 20 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_unique_169108_248_555_+ FIG00000081 6 2 7 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_169110_1_237_- FIG00000146 27 6 28 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_169111_1_555_- FIG00001548 6 5 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_169125_1_337_- FIG00003555 6 4 7 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_169133_1_555_- FIG00002944 151 21 151 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_unique_169178_1_555_- FIG00000402 44 12 46 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_169211_1_362_- FIG00000260 56 10 57 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_169212_1_555_+ FIG00000085 60 14 62 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_169265_1_555_+ FIG00036279 16 4 18 Type III restriction-modification system StyLTI enzyme res (EC 3.1.21.5) Restriction-Modification System 3.x T2D_unique_169271_40_555_- FIG00044478 38 8 39 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_169272_145_555_+ FIG00001548 29 7 30 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_169281_303_555_- FIG00059211 61 9 61 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_169312_1_555_- FIG00001469 22 7 24 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_169328_142_429_+ FIG00000404 11 2 12 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_169358_1_554_- FIG00000156 65 16 67 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_169375_231_554_- FIG00002049 10 5 11 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_169393_1_183_+ FIG00003788 5 2 6 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_169405_1_417_+ FIG00945384 89 14 90 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_169422_1_430_- FIG00229199 101 16 101 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_169438_1_554_+ FIG00106663 139 22 139 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_169449_1_236_- FIG00000601 38 7 39 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_169454_280_554_- FIG00001653 50 9 51 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_169470_1_554_+ FIG00069725 46 8 48 Protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) Ton and Tol transport systems 2 T2D_unique_169491_360_554_+ FIG00064110 26 5 26 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_169503_1_497_- FIG00000510 133 19 133 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_169511_1_554_- FIG00067681 61 12 62 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_169512_51_554_- FIG00002470 34 6 35 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_169550_1_554_+ FIG00001548 10 3 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_169565_1_375_- FIG01955850 21 5 23 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_169580_1_554_- FIG00000114 112 17 113 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_169581_1_554_+ FIG00009544 91 14 92 Late competence protein ComEA, DNA receptor Gram Positive Competence 3100 T2D_unique_169582_1_554_- FIG00132617 48 11 51 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_169602_72_554_- FIG00000288 78 15 79 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_169668_1_230_+ FIG00029916 22 5 23 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_169675_389_554_- FIG00000001 18 5 19 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_169678_1_554_+ FIG00133288 6 3 10 Excinuclease ABC subunit A, dimeric form DNA repair, UvrABC system 1 T2D_unique_169728_1_335_+ FIG00000402 18 6 19 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_169745_1_554_- FIG00001750 35 7 36 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_169771_156_554_+ FIG00000402 85 13 85 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_169787_257_553_+ FIG00001548 5 3 6 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_169794_98_553_- FIG00002049 86 13 86 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_169829_1_553_- FIG00000043 45 9 46 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_169831_1_134_- FIG00000551 12 2 13 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_169878_1_553_+ FIG00000131 135 20 135 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_169902_1_553_+ FIG00025086 47 12 50 Xanthine permease Purine Utilization 1 T2D_unique_169919_1_496_+ FIG00010508 18 5 20 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_169926_279_553_- FIG00000504 19 5 21 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_169934_175_553_+ FIG00001132 81 13 81 LSU ribosomal protein L16p (L10e) Ribosome LSU bacterial 9 T2D_unique_169965_126_553_+ FIG00000348 47 10 49 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_unique_169969_147_553_+ FIG00000721 22 7 23 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_169975_1_553_+ FIG00002847 151 22 151 HflK protein Hfl operon 1.111 T2D_unique_169980_166_534_+ FIG00142507 4 3 5 NADP-reducing hydrogenase, subunit B Hydrogenases 2 T2D_unique_169983_1_553_- FIG00000085 10 3 12 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_170022_266_433_- FIG00004021 4 3 7 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_170087_267_553_+ FIG00024930 67 10 68 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_170106_1_465_- FIG00045413 20 8 22 Glycerol uptake facilitator protein Dihydroxyacetone kinases 3 T2D_unique_170175_218_553_- FIG00000687 82 12 82 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_unique_170176_1_413_- FIG00023004 39 7 40 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_170190_94_553_- FIG00000103 27 8 28 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_170235_8_469_- FIG00134342 109 18 109 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_170253_1_462_+ FIG00058830 46 10 47 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_170260_1_350_+ FIG00000446 8 2 9 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_170271_1_552_+ FIG00846773 98 16 100 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_170276_44_552_+ FIG00000245 40 11 42 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_170277_1_461_- FIG00000421 26 7 27 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_170282_1_552_+ FIG00001088 76 16 78 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_170309_1_552_- FIG00117785 23 9 24 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_unique_170325_329_552_+ FIG01318274 6 4 7 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_170341_1_552_+ FIG00000317 67 13 69 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_170355_1_418_- FIG00000132 19 6 20 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_170358_1_552_- FIG00051439 30 7 31 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_170371_275_406_+ FIG00058830 3 2 4 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_170375_1_156_+ FIG00002914 28 5 28 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_170402_1_271_- FIG00000356 42 8 43 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_170413_1_552_- FIG00012446 5 3 7 Spore germination protein YpeB Spore germination 1 T2D_unique_170451_1_552_- FIG00000412 32 7 33 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_170461_1_552_- FIG00007957 27 7 28 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_170465_1_552_+ FIG00004149 122 20 122 Sialic acid transporter (permease) NanT Sialic Acid Metabolism 1.x T2D_unique_170480_1_552_- FIG00000448 83 17 84 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_170483_1_552_- FIG00016514 5 2 12 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_170512_1_383_+ FIG00075702 15 4 17 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_170515_1_552_- FIG00003535 144 21 145 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_170534_1_552_+ FIG00009096 125 20 126 Galactosamine-6-phosphate isomerase (EC 5.3.1.-) N-Acetyl-Galactosamine and Galactosamine Utilization B.x T2D_unique_170550_1_248_+ FIG00000151 12 4 13 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_170570_1_552_- FIG00000402 29 7 31 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_170584_1_552_+ FIG00000721 161 22 161 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_170607_1_552_+ FIG00000624 144 21 144 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_170622_107_552_+ FIG00000477 3 3 4 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_170673_65_552_+ FIG00009014 133 19 134 Anaerobic sulfite reductase subunit C (EC 1.8.1.-) Anaerobic respiratory reductases 3 T2D_unique_170710_1_236_+ FIG00000118 7 3 8 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_170713_1_551_+ FIG00001562 135 20 135 Methyl-directed repair DNA adenine methylase (EC 2.1.1.72) DNA repair, bacterial 3 T2D_unique_170722_73_551_- FIG00000990 128 18 128 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_170760_1_551_+ FIG00007373 59 11 61 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_170789_136_551_- FIG00001547 4 2 6 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_170833_1_551_- FIG00561498 40 9 42 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_170838_98_551_+ FIG00022300 29 8 30 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_170846_93_551_+ FIG00007495 6 4 8 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_170848_250_551_+ FIG00515041 5 2 7 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Alkanesulfonate assimilation 9.? T2D_unique_170865_330_551_- FIG00003090 8 3 9 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_unique_170879_327_551_- FIG00001106 39 7 40 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_170916_1_272_+ FIG00067248 68 10 68 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_170927_120_551_- FIG00014000 3 3 4 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_170935_1_249_+ FIG00005172 8 2 9 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_170935_250_551_+ FIG00020185 14 5 15 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_170944_1_551_- FIG00000117 23 7 41 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_170952_1_551_- FIG00000168 95 17 96 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_170971_253_551_+ FIG00028694 4 4 6 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_171032_241_551_+ FIG00085033 78 12 78 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_171044_1_551_- FIG00003751 65 14 69 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_171080_1_551_- FIG00000368 15 4 17 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_171082_1_551_- FIG00023943 3 2 5 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_171089_195_377_+ FIG00000738 3 2 5 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_171116_1_551_- FIG00945384 69 13 85 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_171155_417_551_+ FIG00040528 19 3 19 Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282) Quinate degradation 3 T2D_unique_171159_1_551_+ FIG01583289 24 4 26 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_171169_1_551_- FIG00002034 8 3 10 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_171171_1_174_- FIG00000962 4 3 6 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_171175_1_551_- FIG01304530 45 12 46 Phage terminase, large subunit Phage head and packaging 1 T2D_unique_171192_1_551_+ FIG00000831 130 20 131 Na+/H+ antiporter NhaA type Na(+) H(+) antiporter 1 T2D_unique_171238_1_476_- FIG00001518 26 5 27 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_171244_1_550_+ FIG00051439 50 11 52 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_171262_1_550_+ FIG00040817 13 5 15 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_171276_1_389_- FIG00000695 4 2 7 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_171284_405_550_+ FIG00009395 10 3 11 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_unique_171288_1_455_- FIG00000825 61 14 63 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_171300_1_550_+ FIG00011382 7 2 8 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_unique_171301_1_201_+ FIG00000263 23 5 25 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_171301_255_494_+ FIG00000271 31 7 32 LSU ribosomal protein L23p (L23Ae) Ribosome LSU bacterial 9 T2D_unique_171312_1_550_- FIG01307086 8 5 12 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_171315_176_550_+ FIG00000401 12 4 14 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_171317_189_550_+ FIG00023369 64 12 65 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_171319_1_550_+ FIG00000539 65 12 67 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_171371_1_130_- FIG00143531 4 3 6 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_unique_171378_301_550_- FIG00132787 6 2 7 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_171425_1_550_- FIG00006463 20 6 21 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_171458_24_209_+ FIG00025216 29 6 29 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_171461_1_209_- FIG00002968 3 2 4 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_171464_1_550_+ FIG00000287 23 5 25 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_171475_1_201_+ FIG00000243 6 3 8 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_171488_1_387_- FIG00000175 9 2 10 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_171510_1_346_+ FIG00000476 22 6 25 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_171572_260_550_- FIG00000449 46 9 47 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_171594_1_550_+ FIG00002541 92 14 93 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_171599_1_295_+ FIG00013638 68 11 69 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_171602_1_239_- FIG00016514 6 2 7 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_171613_36_550_+ FIG00763261 116 19 117 DNA replication protein DnaC DNA-replication 4 T2D_unique_171652_1_360_+ FIG00016514 66 10 67 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_171676_359_549_- FIG00141373 6 2 7 Regulatory protein SusR Cellulosome 1.x T2D_unique_171678_1_549_+ FIG00000367 14 5 20 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_171728_1_383_+ FIG01260980 49 8 51 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_171813_1_171_+ FIG00000404 14 3 15 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_171822_1_272_- FIG00002320 50 9 50 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_unique_171831_1_418_- FIG00046358 18 6 21 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_171845_1_413_+ FIG00000494 5 5 7 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_171857_1_299_+ FIG00003435 26 7 28 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_171863_391_549_+ FIG00003845 37 6 37 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_171878_1_549_+ FIG00000043 76 14 77 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_171885_1_549_- FIG00003174 12 4 15 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_171888_1_549_+ FIG00007957 57 14 59 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_171892_1_185_- FIG00000126 6 3 7 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_171894_282_549_+ FIG00001388 26 7 28 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_unique_171895_182_549_- FIG00059426 13 5 15 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_171905_118_549_+ FIG00000842 40 9 41 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_171922_202_549_- FIG00000476 65 11 66 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_171928_172_549_- FIG00001824 32 8 33 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_171953_1_549_- FIG00026918 52 10 53 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_171954_1_549_- FIG00168885 69 12 70 Cellobiose phosphorylase (EC 2.4.1.-) Beta-Glucoside Metabolism 2.bc T2D_unique_171957_273_512_- FIG00134889 5 3 6 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_171966_1_549_- FIG00000494 137 21 137 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_171983_1_549_- FIG00014000 114 18 114 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_172005_183_549_+ FIG00000301 45 10 47 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_172042_1_470_- FIG00000207 42 9 44 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_172089_1_549_+ FIG01304601 98 17 99 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_172109_1_549_- FIG00000380 53 12 54 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_172116_1_549_+ FIG00035175 127 20 128 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_172133_1_549_- FIG00000539 61 13 62 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_172153_1_548_+ FIG00036772 74 13 77 Arabinan endo-1,5-alpha-L-arabinosidase (EC 3.2.1.99) L-Arabinose utilization 1 T2D_unique_172192_1_548_- FIG00025086 16 7 22 Xanthine permease Purine Utilization 1 T2D_unique_172281_1_548_- FIG00080955 48 13 50 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_172286_132_548_+ FIG00080955 5 2 7 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_172296_1_548_- FIG01304383 109 18 110 Malate Na(+) symporter Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_172312_1_548_- FIG00138258 31 10 68 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_172314_1_548_- FIG00006997 14 5 16 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_172318_1_548_+ FIG00075702 11 5 13 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_172321_1_548_+ FIG00001834 15 6 17 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_172334_186_539_+ FIG00000770 42 8 43 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_172337_1_459_+ 68 13 83 Putative n-hydroxybenzoate hydroxylase Salicylate and gentisate catabolism 2 T2D_unique_172348_1_330_+ FIG00008778 77 11 77 Maltose operon transcriptional repressor MalR, LacI family Maltose and Maltodextrin Utilization 1.x T2D_unique_172371_93_548_- FIG00016514 29 5 32 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_172372_1_548_- FIG00001469 131 20 131 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_172390_1_548_+ FIG00000404 55 14 56 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_172391_1_548_+ FIG00002385 9 2 10 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_172447_1_548_+ FIG00018699 20 6 23 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_172449_1_380_- FIG00021289 16 5 17 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_172454_1_548_- FIG00016663 116 18 117 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_172468_1_330_+ FIG00009014 54 11 55 Anaerobic sulfite reductase subunit C (EC 1.8.1.-) Anaerobic respiratory reductases 3 T2D_unique_172468_348_548_+ FIG00059898 32 6 34 Assimilatory nitrate reductase large subunit (EC:1.7.99.4) Nitrate and nitrite ammonification 1 T2D_unique_172479_1_548_- FIG00021289 132 21 132 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_172515_1_188_+ FIG00018457 28 5 28 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_172515_199_548_+ FIG00012945 25 6 26 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_172518_1_141_- FIG00025216 27 4 27 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_172538_1_548_+ FIG00000834 80 15 82 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_172548_1_365_+ FIG00000235 23 4 25 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_172559_27_548_- FIG00016566 28 7 29 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_172580_149_548_- FIG00000822 22 7 24 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_172590_1_428_+ FIG00000131 28 7 32 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_172597_1_241_+ FIG00052605 3 2 4 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_172610_1_548_- FIG00010524 16 6 17 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_172671_1_547_- FIG00108342 62 16 63 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_172693_1_512_- FIG00002385 135 20 136 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_172710_263_520_+ FIG00000414 22 4 23 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_172712_1_140_- FIG00000289 6 2 7 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_172748_111_547_- FIG00058830 71 10 72 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_172750_14_397_- FIG00052605 57 10 66 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_172751_59_499_- FIG00002920 22 6 23 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_172772_1_319_- FIG00002968 4 3 7 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_172780_67_547_- FIG00000147 7 4 10 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_172785_1_308_+ FIG00002117 15 3 16 L-arabinose isomerase (EC 5.3.1.4) L-Arabinose utilization 1 T2D_unique_172792_1_547_- FIG01260980 17 5 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_172798_1_547_+ FIG00000303 127 20 128 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_172801_1_547_- FIG00003406 35 9 36 AmpG permease Recycling of Peptidoglycan Amino Acids 1 T2D_unique_172813_95_547_- FIG00000165 124 18 124 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_172866_1_477_- FIG00000897 53 11 55 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_172873_1_547_+ FIG00745599 34 9 48 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_172880_1_547_- FIG00059211 47 10 48 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_172910_1_538_+ FIG00048014 12 4 15 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_172913_1_547_+ FIG00000070 23 9 26 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_172939_278_547_- FIG00000194 56 9 57 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_172952_101_547_- FIG00000967 53 9 54 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_unique_172953_1_547_- FIG00004078 23 9 25 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_172963_1_547_+ FIG00002050 67 13 68 Urease alpha subunit (EC 3.5.1.5) Urease subunits 1.x T2D_unique_172969_1_547_+ FIG00133226 111 19 111 Dihydrolipoamide dehydrogenase of acetoin dehydrogenase (EC 1.8.1.4) Acetoin, butanediol metabolism 5 T2D_unique_172973_1_547_- FIG00000156 59 12 60 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_172984_1_198_+ FIG00000111 12 3 13 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_172996_232_547_+ FIG00561498 85 12 85 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_173011_26_547_+ FIG00000001 7 2 9 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_173014_1_547_- FIG00000343 22 7 24 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_173023_350_547_- FIG00000448 6 3 7 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_173027_1_547_- FIG00000426 9 4 15 Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY Bacterial Chemotaxis 9 T2D_unique_173066_130_547_+ FIG00000287 103 16 103 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_173072_1_547_+ FIG00002011 59 9 60 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_unique_173073_293_547_+ FIG00012468 54 8 54 Lactate-responsive regulator LldR in Firmicutes, GntR family Lactate utilization 3 T2D_unique_173081_1_547_- FIG00000343 45 11 53 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_173082_1_547_- FIG00000578 43 10 45 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_173118_1_383_- FIG00000103 10 2 11 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_173119_1_547_- FIG00000404 10 4 12 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_173125_1_547_- FIG00024930 22 4 23 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_173157_1_546_+ FIG00126843 6 4 7 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_173163_158_469_+ FIG00001011 27 5 29 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_173175_1_546_+ FIG00000446 14 5 16 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_173203_1_546_- FIG00003672 29 8 31 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_unique_173213_1_546_+ FIG00000402 38 10 41 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_173232_1_299_- FIG00046358 13 3 15 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_173247_1_546_- FIG00019454 15 6 16 NrfD protein Nitrate and nitrite ammonification 1 T2D_unique_173262_1_239_- FIG00846773 12 4 13 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_173270_1_546_- FIG00076285 17 4 20 Substrate-specific component STY3230 of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_173282_43_546_- FIG01304225 3 2 4 Phage tail fibers Phage tail fiber proteins 2 T2D_unique_173291_1_546_- FIG00000962 26 8 28 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_173298_1_457_- FIG00004502 117 18 117 5'-nucleotidase YjjG (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_173299_1_546_- FIG00000782 16 5 18 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_173302_106_546_- FIG00031731 9 4 11 CRISPR-associated RAMP protein, Csm4 family CRISPR-associated cluster 1 T2D_unique_173330_1_546_- FIG00000578 56 11 57 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_173332_1_546_+ FIG01318398 150 21 150 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_173341_153_546_+ FIG00134889 14 5 16 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_173367_1_546_- FIG00000139 15 7 17 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_173395_1_546_+ FIG00038920 25 6 26 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_173415_1_309_+ FIG00003465 86 12 86 Outer membrane protein A precursor Osmoregulation 1 T2D_unique_173443_1_132_- FIG01010650 8 2 9 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_173472_46_546_- FIG00013638 101 17 101 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_173518_1_546_- FIG00035175 17 4 18 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_173531_1_444_- FIG00042616 56 11 58 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_173535_1_546_- FIG00001088 6 3 7 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_173538_1_546_+ FIG00019251 26 7 28 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_173543_1_546_+ FIG00024930 41 11 44 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_173545_212_546_- FIG00046929 8 2 10 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_173566_282_546_- FIG00004428 50 9 51 6-phosphofructokinase class II (EC 2.7.1.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_173576_1_279_+ FIG00011114 30 6 30 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_173586_82_546_- FIG00745599 20 5 21 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_173620_216_545_+ FIG00000979 12 3 14 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_unique_173628_1_545_- FIG00000402 144 21 144 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_173643_376_545_+ FIG00455853 6 2 7 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_173648_1_453_+ FIG00000764 43 9 45 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_173653_1_545_- FIG00004078 35 6 36 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_173654_1_545_+ FIG00024401 25 5 26 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_173655_1_545_+ FIG00023369 72 15 73 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_173656_1_545_+ FIG00001366 25 10 30 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_173695_193_545_+ FIG00058830 94 14 95 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_173700_1_545_- FIG00080955 141 21 141 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_173736_1_545_- FIG00005283 103 19 104 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_173747_271_545_+ FIG00035175 17 5 18 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_173762_289_545_+ FIG00026758 7 2 9 Poly-gamma-glutamate synthase subunit PgsB/CapB (EC 6.3.2.-) Poly-gamma-glutamate biosynthesis 3 T2D_unique_173771_14_545_+ FIG00000089 44 15 45 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_173791_1_545_+ FIG00009450 5 3 8 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_173849_94_545_+ FIG00003472 39 9 41 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_173856_337_545_+ FIG00000448 8 2 8 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_173882_1_400_+ FIG00003535 118 16 118 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_173883_247_545_+ FIG00000089 55 10 56 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_173894_1_231_- FIG00018536 7 2 8 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_173914_126_545_+ FIG00051439 26 5 27 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_173921_1_545_+ FIG00057669 5 2 7 Putative CDP-glycerol:glycerophosphate glycerophosphotransferase (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_173931_1_524_+ FIG01031896 41 9 43 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_173968_285_545_+ FIG00000552 37 8 38 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_173969_1_545_- FIG01007502 3 3 5 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_174001_284_545_+ FIG00006868 17 5 20 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_174043_1_545_- FIG00060517 24 6 26 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_174055_1_545_- FIG00051439 141 21 141 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_174075_1_545_- FIG00000365 61 12 63 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_174084_1_544_- FIG01260980 3 3 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_174087_1_544_- FIG00016514 21 4 22 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_174100_1_544_+ FIG00000838 9 4 12 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_174116_1_544_- FIG00475203 26 7 28 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_174120_1_339_- FIG00000392 65 11 66 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_174122_38_544_+ FIG00451095 106 19 106 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_174125_33_544_- FIG00000205 57 11 58 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_174150_1_192_- FIG00042267 4 3 5 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_174157_301_544_- FIG00003495 58 9 58 Rhodanese-like domain protein Glutaredoxins 1 T2D_unique_174162_1_457_+ FIG00846773 95 16 96 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_174187_1_544_+ FIG00064110 64 16 68 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_174188_1_240_+ FIG00000143 43 7 43 Translation initiation factor 1 Translation initiation factors bacterial 1.111 T2D_unique_174212_408_544_+ FIG00099318 16 4 17 RNA polymerase sigma factor SigV Transcription initiation, bacterial sigma factors 1 T2D_unique_174234_191_544_- FIG00846773 14 4 15 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_174238_1_544_+ FIG00018457 3 2 5 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_174243_1_544_+ FIG00140898 121 17 122 periplasmic fructose-binding protein component of signal transduction system LevT Fructose and Mannose Inducible PTS 2 T2D_unique_174253_1_318_+ FIG00000070 19 4 20 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_174253_346_544_+ FIG00023369 24 6 25 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_174258_3_544_- FIG00000986 7 3 10 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_174267_1_544_- FIG00004078 95 16 96 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_174332_1_173_- FIG00001269 16 4 18 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_174347_1_544_+ FIG00002278 52 10 54 NrfC protein Nitrate and nitrite ammonification 1 T2D_unique_174354_1_353_- FIG00000131 23 6 25 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_174358_1_544_- FIG00006152 113 18 114 Putrescine carbamoyltransferase (EC 2.1.3.6) Polyamine Metabolism 2 T2D_unique_174376_133_544_+ FIG00000263 74 13 75 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_174384_1_284_- FIG00002311 72 11 72 Septation ring formation regulator EzrA CBSS-393130.3.peg.794 2 T2D_unique_174391_47_544_- FIG01304636 14 5 15 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_174397_1_544_- FIG00000402 47 8 48 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_174409_1_544_- FIG00001292 101 16 103 D-alanine aminotransferase (EC 2.6.1.21) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_174421_1_345_+ FIG00066425 85 13 86 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_174422_125_427_+ FIG00010508 9 3 11 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_174439_1_544_- FIG00001020 14 4 16 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_174452_1_426_+ FIG00000343 29 8 30 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_174453_1_544_- FIG00000139 23 5 25 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_174488_1_252_- FIG00045144 17 3 19 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_174493_1_408_- FIG00006092 8 3 10 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_174504_1_354_+ FIG00003433 5 2 7 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_174504_368_544_- FIG00002716 9 2 10 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_174541_1_267_- FIG00000899 18 4 19 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_174543_1_240_- FIG00003076 29 5 30 Lactam utilization protein LamB EC699-706 1 T2D_unique_174556_1_543_+ FIG00133219 10 4 12 Thiamin biosynthesis lipoprotein ApbE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_174562_1_543_- FIG00003378 40 11 42 [NiFe] hydrogenase metallocenter assembly protein HypE NiFe hydrogenase maturation 1 T2D_unique_174576_1_543_- FIG00018699 24 9 30 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_174580_1_543_- FIG01010650 24 7 26 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_174585_1_543_- FIG00000350 7 4 8 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_174595_1_543_- FIG00030585 6 5 8 Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_174596_1_326_- FIG00005283 30 8 31 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_174596_328_543_- FIG00005727 20 5 21 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_174601_383_543_- FIG00000163 5 2 6 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_174606_1_543_+ FIG00018396 147 21 147 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_174624_1_543_+ FIG00083946 58 11 59 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_174627_1_543_+ FIG00000147 69 15 71 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_174661_70_543_+ FIG00001550 37 8 39 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_174669_74_543_+ FIG00000764 77 14 79 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_174681_1_543_- FIG00133502 65 14 79 Formate hydrogenlyase subunit 4 Formate hydrogenase 3.1?? T2D_unique_174694_1_199_+ FIG00001407 9 3 10 FKBP-type peptidyl-prolyl cis-trans isomerase fklB (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_174710_14_543_- FIG00067248 23 4 24 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_174789_1_543_+ FIG00010454 9 5 11 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_174805_161_543_+ FIG00000117 20 7 21 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_174834_218_543_- FIG00055520 5 2 7 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_174845_1_493_+ FIG00136692 4 2 5 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_174865_1_543_+ FIG00000011 9 4 12 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_174950_1_543_- FIG00001088 24 6 27 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_174952_1_543_- FIG00020897 16 6 18 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_174999_42_543_+ FIG00007025 16 7 22 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_175051_1_128_+ FIG00031250 17 3 18 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_175051_278_542_+ FIG00004021 18 5 20 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_175073_1_244_+ FIG00719736 9 5 10 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_175101_14_542_+ FIG00007941 44 9 45 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_175114_1_542_+ FIG00000130 36 7 37 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_175166_1_542_+ FIG00000011 34 9 37 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_175195_1_374_- FIG00134060 42 11 43 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_175224_1_359_+ FIG00008708 12 3 14 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_175227_22_542_+ FIG00000421 31 8 34 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_175230_1_509_- FIG00000081 6 4 7 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_175231_1_353_- FIG00010600 26 6 29 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_175241_1_542_+ FIG00000043 79 14 80 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_175253_1_542_+ FIG00018457 3 4 5 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_175255_1_542_- FIG00018699 92 15 93 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_175265_316_542_+ FIG00002299 61 8 61 Ascorbate-specific PTS system, EIIB component (EC 2.7.1.69) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_175266_281_542_+ FIG00005172 10 3 11 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_175286_1_542_- FIG00000962 37 8 39 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_175306_13_542_- FIG00000146 51 10 54 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_175313_1_293_- FIG00133569 5 2 7 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_175374_358_542_- FIG00000114 7 2 9 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_175378_98_466_- FIG00093180 5 3 6 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_175390_1_542_+ FIG00229386 44 9 45 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_175404_185_542_- FIG00001132 6 2 7 LSU ribosomal protein L16p (L10e) Ribosome LSU bacterial 9 T2D_unique_175431_312_542_+ FIG00003955 58 9 58 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_175449_1_542_+ FIG00001166 69 14 71 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_175461_387_542_- FIG00000352 19 4 20 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_175476_1_542_- FIG00000681 20 5 23 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_unique_175492_1_397_+ FIG00000578 38 8 39 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_175505_213_542_+ FIG01304225 27 5 28 Phage tail fibers Phage tail fiber proteins 2 T2D_unique_175541_249_541_+ FIG00001882 59 11 59 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_175556_1_541_- FIG00003472 44 11 45 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_175574_1_541_+ FIG00038343 8 3 11 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_175599_1_488_+ FIG00002020 26 5 28 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_175647_189_541_+ FIG00135742 9 3 11 Ribonuclease HI-related protein Ribonuclease H 1.010 T2D_unique_175735_1_207_- FIG00000422 5 3 6 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_175778_137_541_- FIG00010524 12 4 15 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_175794_1_541_+ FIG00001670 40 8 42 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_175805_260_541_- FIG00846773 4 4 5 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_175817_1_416_+ FIG00013638 75 15 75 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_175825_1_268_+ FIG00000911 23 5 24 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_175828_323_541_+ FIG00001960 10 4 12 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_175854_125_541_- FIG00003251 96 16 97 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_175856_1_235_- FIG01007502 11 3 13 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_175914_351_541_- FIG00035701 47 7 47 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_175920_400_541_+ FIG00000308 5 2 6 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_175921_1_541_+ FIG00000080 61 16 62 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_175922_279_541_+ FIG00000449 44 9 45 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_175928_1_541_+ FIG00000482 54 13 56 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_175929_1_541_+ FIG00130344 94 16 95 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_175935_1_541_+ FIG00000402 11 8 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_175937_1_326_+ FIG00340292 8 2 9 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_175973_82_541_+ FIG00002920 25 6 27 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_175984_1_334_+ FIG01007502 37 6 38 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_175994_119_541_- FIG00138354 90 15 90 Alkanesulfonates transport system permease protein Alkanesulfonates Utilization 20 T2D_unique_176018_387_541_- FIG00000095 22 4 23 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_176049_1_541_- FIG00001960 75 11 77 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_176053_1_541_+ FIG00059211 75 15 76 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_176085_1_540_- FIG00000338 147 21 147 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_176150_1_540_- FIG00000116 8 2 10 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_176172_358_540_+ FIG00067248 13 4 20 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_176176_1_540_+ FIG00475203 13 6 15 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_176203_1_472_+ FIG00000620 98 15 98 Phosphoheptose isomerase (EC 5.3.1.-) CBSS-160492.1.peg.550 1 T2D_unique_176208_1_540_- FIG00003788 36 8 37 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_176234_1_540_- FIG00016566 58 11 59 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_176253_3_269_- FIG00000532 4 3 6 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_176257_176_540_+ FIG00067750 87 14 87 Metal-dependent hydrolases of the beta-lactamase superfamily II Beta-lactamase 1 T2D_unique_176298_1_540_+ FIG00023369 92 17 93 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_176314_1_455_+ FIG00000080 37 9 46 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_176323_1_540_+ FIG00020218 14 7 17 Fused spore maturation proteins A and B Spore Core Dehydration 1.1 T2D_unique_176328_1_540_- FIG00001653 28 8 31 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_176347_1_540_+ FIG00000139 16 5 18 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_176377_246_540_+ FIG00561003 7 2 8 putative glycosyltransferase protein CBSS-258594.1.peg.3339 1 T2D_unique_176378_1_233_+ FIG00001819 9 3 11 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_176422_1_412_- FIG00000070 3 3 5 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_176432_117_540_+ FIG00000351 3 3 5 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_176451_1_235_- FIG00000477 6 2 11 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_176458_1_185_- FIG00001824 5 2 6 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_176468_1_291_+ FIG00000578 74 11 74 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_176469_1_447_- FIG00002416 33 6 34 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_176473_1_540_+ FIG00043527 72 11 74 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_176496_1_313_+ FIG00024930 43 9 44 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_176508_1_540_- FIG00046929 25 8 27 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_176523_1_540_- FIG00000962 123 19 124 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_176527_1_540_+ FIG00075702 61 14 62 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_176550_1_540_- FIG00000441 24 6 25 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_176587_1_540_+ FIG00000812 27 10 61 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_176593_285_540_- FIG00000329 47 8 48 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_176595_1_540_- FIG00000842 41 10 43 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_176608_1_539_- FIG00018396 73 13 74 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_176615_1_539_- FIG00001088 4 5 10 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_176643_1_539_- FIG00001642 30 8 32 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_176650_347_539_+ FIG00001548 50 7 50 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_176679_1_539_+ FIG00000279 104 17 105 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_176687_1_539_- FIG00000948 14 3 15 Poly(A) polymerase (EC 2.7.7.19) Polyadenylation bacterial 2 T2D_unique_176696_1_539_- FIG00050243 13 4 20 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_176701_1_539_+ FIG00005698 61 13 64 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_176704_1_539_+ FIG00001548 11 4 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_176712_1_539_- FIG00000402 118 20 119 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_176741_1_539_+ FIG00000456 46 10 47 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_176757_1_204_+ FIG00000504 55 8 55 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_176764_1_539_- FIG00000782 8 3 10 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_176785_1_539_+ FIG00000962 39 11 40 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_176794_1_539_- FIG00046358 17 6 19 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_176801_112_539_+ FIG00009156 113 17 113 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_176897_409_539_+ FIG00001269 24 4 24 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_176909_102_539_- FIG00000477 5 4 6 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_176919_1_539_+ FIG00002416 143 21 143 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_176933_39_539_- FIG00001932 31 8 32 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_176937_1_539_- FIG00047414 143 21 143 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_176970_1_347_- FIG00453259 80 12 81 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_176983_178_539_+ FIG00000277 50 10 51 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_176987_1_539_+ FIG00000241 60 15 61 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_177001_1_539_- FIG00023369 86 14 88 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_177006_1_436_+ FIG00059211 9 4 11 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_177061_31_539_- FIG00006032 7 2 8 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_177063_1_539_+ FIG00017454 17 6 18 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_177074_79_539_- FIG00018396 30 10 31 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_177094_1_539_- FIG00000990 55 11 56 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_177096_1_288_+ FIG00001022 11 3 12 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_177103_1_538_+ FIG00000001 4 3 6 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_177114_1_298_+ FIG00002110 34 6 35 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_177127_1_345_+ FIG00038920 99 14 99 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_177129_1_538_+ FIG00000329 79 15 80 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_177137_170_538_- FIG00000358 14 6 21 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_177157_15_538_+ FIG00000126 38 11 39 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_177162_1_538_+ FIG00000185 15 6 18 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_177174_1_179_+ FIG00000121 29 4 30 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_177193_1_538_- FIG00000402 29 7 30 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_177207_40_538_- FIG00000380 13 4 14 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_177231_134_538_+ FIG00011622 3 3 5 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_177252_263_538_- FIG00000143 24 6 26 Translation initiation factor 1 Translation initiation factors bacterial 1.111 T2D_unique_177261_1_538_+ FIG00796613 35 6 36 Beta-phosphoglucomutase (EC 5.4.2.6) Maltose and Maltodextrin Utilization 1.x T2D_unique_177270_1_538_- FIG00846773 94 15 96 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_177317_1_515_+ FIG00001269 80 14 81 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_177332_287_538_+ FIG00001548 10 2 11 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_177333_1_538_- FIG00020613 82 16 84 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_177344_1_538_- FIG01560076 4 3 6 Glycosyl transferase, group 1 CBSS-258594.1.peg.3339 1 T2D_unique_177346_1_538_- FIG00025086 106 19 106 Xanthine permease Purine Utilization 1 T2D_unique_177357_1_538_- FIG01260980 13 4 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_177359_54_323_- FIG00015231 3 3 5 Inhibitor of pro-sigmaK processing BofA DNA processing cluster 1.1 T2D_unique_177362_249_538_- FIG00133292 11 4 12 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_177376_191_538_- FIG00062547 25 6 26 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_177379_81_538_+ FIG00003270 91 15 92 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_unique_177388_1_172_- FIG00001067 15 3 16 Rubrerythrin Oxidative stress 1.2 T2D_unique_177393_275_538_- FIG00001531 22 4 23 D-alanyl transfer protein DltB D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_177404_1_538_+ FIG01260980 134 20 135 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_177409_1_538_+ FIG00018369 30 12 32 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_177412_1_470_+ FIG00004688 70 12 70 Hypothetical, related to broad specificity phosphatases COG0406 CBSS-196164.1.peg.461 2 T2D_unique_177420_204_538_+ FIG00000899 20 4 21 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_177436_1_538_+ FIG00085033 136 21 136 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_177439_1_538_- FIG00003174 5 2 6 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_177461_1_538_- FIG01260980 4 4 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_177472_1_538_+ FIG00008778 147 22 147 Maltose operon transcriptional repressor MalR, LacI family Maltose and Maltodextrin Utilization 1.x T2D_unique_177488_1_538_+ FIG00000146 39 11 45 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_177516_1_202_+ FIG00005172 9 2 10 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_177541_246_538_- FIG00136692 33 6 35 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_177546_1_538_- FIG00000414 95 16 97 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_177554_1_281_- FIG00000962 50 7 51 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_177562_1_486_+ FIG00009395 51 11 52 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_unique_177571_57_509_+ FIG00002968 10 4 12 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_177592_1_538_- FIG00000210 3 3 6 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_177596_1_537_+ FIG01304530 6 2 8 Phage terminase, large subunit Phage head and packaging 1 T2D_unique_177614_1_383_- FIG00000482 8 4 13 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_177617_303_537_+ FIG00025086 56 9 56 Xanthine permease Purine Utilization 1 T2D_unique_177633_1_450_+ FIG00000113 126 18 126 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_177642_1_485_+ FIG00000023 84 16 86 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_unique_177660_1_537_- FIG00017454 59 12 60 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_177661_84_537_+ FIG00029916 112 17 112 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_177664_1_537_+ FIG00136692 89 16 90 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_177665_272_537_+ FIG00099318 6 2 8 RNA polymerase sigma factor SigV Transcription initiation, bacterial sigma factors 1 T2D_unique_177699_1_357_- FIG00002385 7 2 10 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_177716_8_433_- FIG00058189 78 12 78 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_unique_177734_1_506_- FIG00134889 23 8 25 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_177736_1_537_+ FIG01260980 25 9 26 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_177770_1_362_- FIG01290653 6 2 8 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_177794_397_537_- FIG00022300 38 5 38 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_177803_1_537_- FIG00018699 31 8 32 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_177807_1_537_+ FIG00138018 9 2 11 Alpha-glucosidase SusB (EC 3.2.1.20) Cellulosome 1.x T2D_unique_177824_1_537_+ FIG00001642 34 7 36 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_177827_1_537_- FIG00086697 4 2 6 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_177850_1_537_- FIG00000552 13 3 15 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_177851_1_537_- FIG00126843 87 14 88 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_177864_284_537_- FIG00002414 17 4 18 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_unique_177885_1_335_+ FIG00000168 84 13 84 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_177885_367_537_+ FIG00001133 19 3 20 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_unique_177886_220_537_- FIG01304052 26 5 26 Carbon starvation protein A paralog Carbon Starvation 1.21 T2D_unique_177948_1_537_+ FIG00002300 154 21 154 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_177979_1_537_- FIG00000116 30 9 33 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_177996_145_537_+ FIG00035175 53 11 54 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_178018_1_537_- FIG00006953 10 4 11 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_unique_178034_1_537_+ FIG00229257 155 21 155 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_178042_83_537_- FIG01955774 38 9 39 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_178054_1_537_+ FIG00000396 10 6 11 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_178072_1_537_- FIG00139579 14 4 16 Uncharacterized protein YtfM precursor Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_178076_284_537_+ FIG00001175 5 3 7 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_178083_128_537_+ FIG00000147 14 4 26 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_178091_1_163_+ FIG00002354 14 4 15 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_178094_1_537_- FIG00005172 135 20 135 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_178112_41_536_+ FIG00018224 26 7 28 Substrate-specific component MtsA of methionine-regulated ECF transporter ECF class transporters 345678 T2D_unique_178141_1_536_+ FIG00138004 20 6 25 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_178193_197_536_+ FIG01955809 80 13 80 Cytoplasmic copper homeostasis protein cutC Copper homeostasis: copper tolerance 3 T2D_unique_178206_192_536_- FIG00846773 3 3 5 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_178207_1_536_- FIG00000404 16 3 18 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_178227_1_536_+ FIG00000402 55 12 57 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_178242_1_500_+ FIG00000380 94 14 95 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_178244_36_536_+ FIG00006997 4 4 6 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_178256_1_536_- FIG00010600 12 3 14 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_178289_213_536_- FIG00000261 36 9 37 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_178293_1_516_+ FIG00008490 49 8 50 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_178294_1_326_+ FIG00001469 30 8 59 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_178310_123_536_- FIG00000624 9 2 10 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_178319_1_536_+ FIG00018699 30 8 33 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_178329_1_536_- FIG00561498 13 4 14 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_178338_106_536_+ FIG00026750 27 7 28 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_unique_178342_1_536_+ FIG00108342 50 13 52 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_178364_1_536_- FIG00006955 142 21 142 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_178374_1_536_+ FIG00000434 18 4 23 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_178381_146_536_- FIG00001052 21 5 23 ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) LOS core oligosaccharide biosynthesis 1.x T2D_unique_178383_1_536_+ FIG00000539 51 12 53 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_178388_1_512_+ FIG00000317 10 4 13 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_178408_1_436_+ FIG00001088 11 5 12 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_178438_1_536_+ FIG00013626 59 10 60 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_178453_1_536_- FIG00000556 16 4 18 2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase (EC 2.5.1.55) Chorismate Synthesis 1 T2D_unique_178466_1_535_+ FIG00026006 124 20 124 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_178468_1_487_+ FIG00000165 18 6 20 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_178473_1_531_+ FIG01260980 15 4 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_178479_1_288_+ FIG00017190 7 3 9 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_178496_1_536_- FIG00011659 21 8 23 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_178505_1_277_- FIG00000741 12 5 14 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_unique_178516_1_536_+ FIG00003894 7 6 10 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_178549_1_536_+ FIG00001548 14 6 15 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_178609_105_284_- FIG00000126 14 5 15 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_178620_123_536_+ FIG00003251 37 10 38 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_178630_1_535_- FIG00001583 5 3 6 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_178657_101_535_- FIG00000279 104 16 105 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_178685_342_535_+ FIG00003251 10 4 11 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_178695_1_535_- FIG00002020 46 11 47 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_178696_236_535_- FIG00000112 21 6 26 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_178698_1_535_+ FIG00026137 52 10 55 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_178699_1_535_- FIG00007039 6 2 8 Multiple sugar ABC transporter, membrane-spanning permease protein MsmG Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_178714_239_535_- FIG00000979 67 10 67 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_unique_178761_1_192_- FIG00002772 42 7 42 Phosphopantothenoylcysteine synthetase (EC 6.3.2.5) Coenzyme A Biosynthesis A.191 T2D_unique_178761_317_535_+ FIG00001635 8 3 9 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_178789_1_535_+ FIG00340292 3 3 7 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_178803_23_535_+ FIG00000352 92 16 93 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_178805_203_535_- FIG00000990 21 5 22 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_178807_1_535_+ FIG00052605 21 7 24 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_178831_325_535_- FIG00006691 18 4 19 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_178876_103_535_- FIG00000163 118 17 118 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_178887_1_535_+ FIG00000594 29 6 31 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_178894_142_535_- FIG00000001 61 10 63 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_178897_1_477_+ FIG00031250 7 4 10 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_178931_1_535_+ FIG01255877 56 12 62 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_178939_1_535_+ FIG01303775 87 15 87 GTP-binding protein related to HflX Hfl operon 1.111 T2D_unique_178957_1_535_+ FIG00016514 10 4 13 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_178958_1_355_+ FIG00000210 32 10 33 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_178997_1_535_- FIG00005022 5 3 8 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_179002_2_535_- FIG00561498 12 2 14 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_179015_341_535_+ FIG00000194 14 3 15 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_179038_1_535_+ FIG00001469 36 8 37 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_179059_260_535_- FIG00133292 4 3 6 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_179060_1_535_+ FIG00049915 42 9 43 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_179063_1_535_+ FIG00132586 66 13 66 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_179076_1_535_+ FIG00000494 8 4 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_179097_395_535_+ FIG01318274 3 2 5 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_179110_1_534_- FIG00000146 84 18 85 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_179151_1_381_- FIG00000038 77 13 78 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_179157_1_534_- FIG00132617 56 12 57 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_179159_1_534_- FIG00010285 92 18 93 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_179167_248_534_- FIG00007328 19 3 20 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_179184_95_534_- FIG00000207 9 3 17 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_179187_103_534_+ FIG00024930 15 5 16 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_179241_1_429_+ FIG00000494 4 2 6 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_179242_127_534_+ FIG00001105 16 8 18 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_unique_179250_111_534_- FIG00009156 6 2 7 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_179292_1_370_+ FIG00083946 31 7 33 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_179294_1_534_- FIG00000899 63 12 64 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_179333_1_308_- FIG00001067 30 6 31 Rubrerythrin Oxidative stress 1.2 T2D_unique_179339_1_344_+ FIG00000997 8 7 13 Protein RtcB RNA 3'-terminal phosphate cyclase 2 T2D_unique_179381_1_534_- FIG00006128 17 10 29 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_179386_1_168_+ FIG00002410 15 3 16 Recombinational DNA repair protein RecT (prophage associated) DNA repair, bacterial 3 T2D_unique_179405_1_534_+ FIG00001469 21 6 22 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_179406_233_534_- FIG00108342 5 2 7 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_179417_1_534_+ FIG00066643 7 4 9 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_179426_1_534_+ FIG00000097 20 4 22 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_179473_298_534_- FIG00088522 48 7 49 Melibiose carrier protein, Na+/melibiose symporter Melibiose Utilization A T2D_unique_179474_1_381_+ FIG00006165 18 4 19 Uracil-DNA glycosylase, family 4 Uracil-DNA glycosylase 1 T2D_unique_179521_366_534_+ FIG00000834 39 6 39 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_179538_1_190_+ FIG00031250 9 3 10 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_179563_1_453_+ FIG00095112 4 4 7 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) DNA-replication 4 T2D_unique_179576_123_534_- FIG00011622 96 15 96 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_179592_1_464_- FIG00835431 4 2 6 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_179606_125_534_+ FIG00000594 31 7 32 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_179650_1_287_- FIG00007049 65 10 65 Nickel transport system permease protein nikB2 (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_179650_299_533_- FIG00007431 66 9 66 Nickel ABC transporter, periplasmic nickel-binding protein nikA2 (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_179664_229_533_+ FIG00047414 52 10 53 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_179696_150_533_+ FIG00016514 29 6 30 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_179757_1_336_+ FIG00561498 4 2 5 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_179803_296_533_+ FIG00017160 8 2 9 Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_179819_1_462_+ FIG00000402 20 6 22 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_179875_1_533_+ FIG00000680 17 6 18 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_179902_263_533_+ FIG01255877 9 2 10 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_179912_1_416_- FIG00846773 69 12 70 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_179917_1_533_- FIG00000372 13 7 14 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_179923_1_287_- FIG00000143 21 4 22 Translation initiation factor 1 Translation initiation factors bacterial 1.111 T2D_unique_179937_1_533_- FIG00002049 7 4 9 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_180010_74_533_+ FIG01280345 110 17 110 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_180011_1_157_- FIG00000070 6 3 7 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_180015_1_533_+ FIG00028203 60 13 61 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_180016_231_533_- FIG00000040 6 2 7 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_180043_1_315_- FIG00136692 27 5 28 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_180058_1_533_- FIG00001649 13 5 15 N-methylhydantoinase A (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_180060_1_358_- FIG00035627 25 7 27 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_180130_310_533_+ FIG00000522 14 3 15 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_180182_1_291_+ FIG00012267 19 6 20 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_180216_1_292_+ FIG00000126 43 9 45 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_180218_1_532_- FIG00010844 12 3 14 Flavodoxin Flavodoxin 1 T2D_unique_180264_1_141_- FIG00000001 3 2 5 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_180279_1_532_- FIG00006336 63 9 64 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_180280_1_373_+ FIG00001198 5 2 9 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_180311_1_532_+ FIG00000838 17 4 18 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_180321_14_532_- FIG00009395 12 4 13 Substrate-specific component ThiW of predicted thiazole ECF transporter ECF class transporters 345678 T2D_unique_180341_1_291_- FIG00012945 15 2 16 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_180343_1_532_+ FIG00000504 145 21 145 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_180362_379_532_- FIG00003270 17 4 18 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_unique_180366_1_234_+ FIG00000097 30 5 31 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_180370_1_532_+ FIG01260980 20 9 21 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_180371_295_532_- FIG00019251 7 2 8 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_180381_1_532_+ FIG00000834 156 21 156 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_180421_293_532_+ FIG00019251 16 6 17 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_180437_90_532_+ FIG00005022 8 2 9 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_180454_1_532_- FIG00001647 8 2 10 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_180463_1_532_- FIG00001088 14 7 16 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_180473_1_334_- FIG00036983 29 7 30 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_180515_1_251_- FIG00004764 23 5 24 Ammonium transporter Ammonia assimilation 1 T2D_unique_180545_1_532_- FIG00042267 19 6 20 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_180546_1_443_+ FIG00000122 115 17 116 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_180571_334_532_+ FIG00000358 25 5 25 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_180575_1_190_+ FIG00010876 5 3 8 Two-component sensor kinase YesM (EC 2.7.3.-) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_180596_1_532_- FIG00010508 34 9 35 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_180605_1_532_- FIG00017454 62 11 63 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_180619_282_532_+ FIG00000103 42 9 43 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_180629_1_231_+ FIG00059211 8 3 9 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_180647_1_531_+ FIG00132617 5 5 15 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_180650_1_531_+ FIG00060517 36 10 38 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_180690_1_531_+ FIG00000401 73 15 75 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_180716_1_305_- FIG00136866 11 4 13 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_180746_360_531_- FIG00001653 18 3 19 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_180820_1_191_+ FIG00008507 11 4 12 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_180844_1_531_- FIG00000317 72 14 73 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_180919_170_531_- FIG00008556 5 2 6 L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_180931_1_531_+ FIG00000070 138 21 138 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_180945_1_531_- FIG00001706 12 3 15 Copper sensory histidine kinase CpxA Orphan regulatory proteins 1 T2D_unique_180946_197_424_+ FIG00000720 41 6 42 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_180950_1_531_+ FIG00007059 11 9 20 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_180974_382_531_+ FIG00000047 10 3 11 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_180986_269_531_- FIG00011114 40 9 42 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_180993_1_531_+ FIG00048014 113 19 114 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_181007_175_531_+ FIG00000224 19 4 21 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_181012_1_531_- FIG00022488 112 18 113 Gluconate permease D-gluconate and ketogluconates metabolism 1.3 T2D_unique_181021_136_531_- FIG01007502 19 6 20 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_181045_1_216_+ FIG00001642 6 2 7 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_181108_1_531_- FIG00019652 62 13 63 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_181139_1_531_+ FIG00009014 152 21 152 Anaerobic sulfite reductase subunit C (EC 1.8.1.-) Anaerobic respiratory reductases 3 T2D_unique_181160_310_530_- FIG00001065 9 2 10 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_181164_1_338_+ FIG00001583 81 13 81 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_181168_147_530_+ FIG00005587 3 2 4 Transcriptional regulator of rhamnose utilization, AraC family L-rhamnose utilization 1 T2D_unique_181169_1_530_+ FIG00008230 6 5 8 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_181213_1_282_+ FIG00000022 61 9 62 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_unique_181216_1_530_+ FIG00003949 13 4 15 Fucose permease L-fucose utilization 1 T2D_unique_181223_1_530_+ FIG00001548 23 5 25 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_181224_1_530_- FIG00041382 31 8 33 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_181233_1_223_+ FIG00000116 26 6 27 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_181238_1_530_- FIG00046929 132 20 132 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_181266_1_454_+ FIG00038920 84 12 87 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_181268_1_530_+ FIG00001548 42 9 44 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_181281_45_530_- FIG00000157 11 4 13 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_181297_1_451_- FIG00024930 13 4 14 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_181304_1_530_- FIG00052605 42 12 44 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_181320_1_312_- FIG00000001 17 6 19 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_181325_1_287_+ FIG00018369 9 3 10 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_181353_81_530_- FIG00001402 27 7 30 Helicase loader DnaI DNA-replication 4 T2D_unique_181358_1_530_+ FIG00002968 13 8 19 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_181360_1_530_- FIG00093180 12 6 13 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_181403_1_276_+ FIG00018369 24 5 25 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_181405_1_530_+ FIG00000242 30 9 33 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_181414_1_329_- FIG00000477 12 3 13 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_181415_1_530_- FIG00001198 58 10 59 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_181429_1_160_+ FIG00002328 15 4 16 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_181434_1_530_- FIG00001548 38 8 39 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_181441_1_530_+ FIG00000304 27 8 29 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_181442_1_530_+ FIG00040817 62 13 63 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_181456_1_530_+ FIG00000387 74 14 75 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_181478_1_530_+ FIG00001653 142 21 142 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_181498_1_530_+ FIG00000025 106 17 107 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_181517_83_530_- FIG00003844 56 11 57 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily F2 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_181520_1_246_+ FIG00140555 11 2 13 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_181528_275_530_- FIG00000402 24 5 25 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_181533_37_530_+ FIG00004413 36 9 38 Pantothenate kinase type II, eukaryotic (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_181538_1_530_+ FIG00001642 43 11 45 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_181544_1_530_- FIG00000571 14 5 15 Signal transduction histidine kinase CheA (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_unique_181555_61_530_+ FIG00020363 12 5 14 ABC-type tungstate transport system, periplasmic binding protein ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_181584_403_530_+ FIG00004014 7 2 8 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_181621_302_530_+ FIG00034392 49 8 49 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_181658_1_277_- FIG00079822 3 2 5 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_181667_1_530_- FIG00038920 17 5 19 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_181735_16_529_- FIG00000673 70 14 104 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_unique_181779_1_529_+ FIG00000001 94 15 95 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_181816_1_441_+ FIG00008348 98 17 98 Predicted transcriptional regulator of N-Acetylglucosamine utilization, GntR family Chitin and N-acetylglucosamine utilization 2 T2D_unique_181821_1_529_+ FIG00067681 126 20 127 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_181841_1_524_+ FIG00001687 10 3 11 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_181852_1_496_+ FIG00093180 14 6 17 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_181868_1_251_+ FIG00080955 12 3 13 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_181868_375_529_+ FIG00000017 11 5 12 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_181874_1_227_- FIG00000263 61 9 61 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_181892_369_529_- FIG00008507 31 5 32 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_181903_1_529_- FIG00021407 54 10 56 (R)-citramalate synthase (EC 2.3.1.182) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_181914_1_529_- FIG00001548 32 6 35 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_181927_1_529_+ FIG00000080 133 20 133 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_181939_1_280_- FIG00000097 20 4 21 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_181949_1_453_+ FIG00025216 35 9 37 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_181956_1_529_- FIG00007373 48 10 49 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_181973_1_529_- FIG00000025 34 7 35 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_181975_1_529_+ FIG00064110 66 16 68 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_181981_211_390_- FIG00002354 16 4 17 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_181992_39_529_- FIG00001203 38 10 44 Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_182012_1_194_+ FIG00018561 30 5 33 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_182018_270_529_+ FIG00018897 3 2 6 Sulfate transport system permease protein CysT Cysteine Biosynthesis 2.17 T2D_unique_182045_376_529_+ FIG00000672 27 5 27 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_182049_63_529_- FIG00007025 37 11 40 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_182118_1_529_+ FIG01260980 135 20 136 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_182127_1_253_+ FIG00453259 25 5 26 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_182156_1_529_+ FIG00019652 38 9 40 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_182157_1_529_- FIG00006699 8 3 9 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_unique_182161_1_529_- FIG00001547 10 3 12 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_182179_1_365_- FIG00006868 75 13 76 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_182182_1_529_- FIG00000038 40 7 41 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_182194_1_529_+ FIG00129616 35 12 37 GTP-binding protein EngA Universal GTPases 2 T2D_unique_182197_1_529_+ FIG00002470 40 8 41 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_182198_1_529_- FIG00000304 135 21 135 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_182202_1_410_- FIG00000036 48 10 49 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_182224_1_528_- FIG00001020 23 8 26 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_182225_1_528_+ FIG01260980 62 15 63 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_182239_22_528_- FIG00001499 127 19 128 GTP-binding protein YqeH, required for biogenesis of 30S ribosome subunit Universal GTPases 2 T2D_unique_182249_1_528_+ FIG00000139 122 20 122 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_182257_341_528_+ FIG00050603 31 5 32 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_182266_1_149_+ FIG00010844 3 2 4 Flavodoxin Flavodoxin 1 T2D_unique_182267_1_528_- FIG01318398 79 11 80 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_182290_1_528_+ FIG00043547 137 20 137 Lipoteichoic acid synthase LtaS Type IIa Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_182342_1_147_+ FIG00001518 14 3 15 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_182358_221_528_+ FIG00000159 31 8 32 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_182362_1_461_+ FIG00000023 23 6 25 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_unique_182371_1_528_+ FIG00012446 5 3 7 Spore germination protein YpeB Spore germination 1 T2D_unique_182374_1_528_- FIG00028203 3 2 4 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_182375_1_319_- FIG00000425 21 5 23 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_182417_1_528_- FIG00001522 36 9 37 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_182433_1_528_+ FIG00000114 23 8 25 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_182446_363_528_- FIG00090781 27 5 27 LSU ribosomal protein L14p (L23e) Ribosome LSU bacterial 9 T2D_unique_182473_230_528_+ FIG00001616 9 3 10 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_182508_130_528_+ FIG00007059 27 4 29 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_182514_1_528_- FIG01260980 21 8 23 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_182537_1_480_+ FIG00000047 27 9 34 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_182538_1_265_+ FIG00001406 30 6 31 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_182558_1_528_- FIG00059211 34 8 35 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_182565_1_528_- FIG00028203 32 8 33 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_182573_1_387_- FIG00005698 69 11 71 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_182588_392_528_- FIG00023268 3 2 4 DNA-binding protein HU-beta DNA structural proteins, bacterial 1.1100 T2D_unique_182605_1_528_+ FIG00018699 12 6 15 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_182607_67_528_- FIG00016663 115 18 116 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_182625_1_217_+ FIG01304043 8 2 9 Competence/damage-inducible protein CinA CBSS-257314.1.peg.676 4.x T2D_unique_182629_1_528_+ FIG00059211 102 18 104 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_182635_1_470_- FIG00000234 34 9 36 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_182685_1_505_+ FIG00031250 86 14 87 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_182694_263_528_+ FIG00008490 12 4 14 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_182703_1_528_- FIG00000477 91 15 92 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_182708_1_417_+ FIG00229386 41 7 44 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_182719_1_528_+ FIG00000397 11 3 13 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_182733_50_527_+ FIG00025748 132 18 132 Accessory colonization factor AcfD precursor Accessory colonization factor 2 T2D_unique_182795_1_527_+ FIG00000289 7 5 9 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_182811_1_527_- FIG00000476 14 5 16 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_182815_1_337_- FIG00000555 56 8 57 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_182817_1_527_- FIG00001548 51 9 52 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_182820_370_527_+ FIG00000624 21 4 22 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_182827_203_463_- FIG00000011 17 5 19 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_182832_147_527_+ FIG00000538 33 6 34 Uracil-DNA glycosylase, family 1 Uracil-DNA glycosylase 1 T2D_unique_182833_1_527_- FIG00029916 32 8 33 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_182846_1_527_+ FIG00034293 39 8 41 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_182848_52_527_+ FIG00000687 36 8 37 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_unique_182861_245_527_- FIG01124301 7 4 9 Arsenical resistance operon repressor Arsenic resistance 1 T2D_unique_182867_1_241_- FIG00003251 26 5 27 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_182867_332_527_- FIG00003251 40 7 40 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_182871_1_216_+ FIG00003955 9 3 11 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_182881_94_321_+ FIG00008490 8 3 9 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_182895_81_527_+ FIG00011906 91 15 92 LysR family transcriptional regulator STM2281 DNA-binding regulatory proteins, strays 1 T2D_unique_182903_1_527_- FIG00007328 50 10 52 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_182926_1_527_+ FIG01176807 11 5 13 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_182943_53_527_- FIG00000075 4 4 6 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_182945_1_161_- FIG00002020 13 3 14 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_182946_1_527_+ FIG00052730 38 10 40 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_182957_1_527_+ FIG01956356 15 4 17 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_182965_1_527_+ FIG00002470 6 3 8 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_182996_1_436_+ FIG00000376 14 4 16 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_183009_260_527_+ FIG00010844 21 6 22 Flavodoxin Flavodoxin 1 T2D_unique_183011_1_527_- FIG00000494 9 3 11 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_183017_1_527_- FIG00007079 121 19 122 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_183019_1_527_- FIG00001094 40 11 43 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_183028_1_404_+ FIG00000112 32 8 33 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_183032_1_344_- FIG00000476 8 2 9 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_183032_348_527_- FIG00028461 13 3 14 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_183053_377_527_+ FIG00139491 3 2 5 NAD-reducing hydrogenase subunit HoxE (EC 1.12.1.2) Hydrogenases 2 T2D_unique_183060_210_527_- FIG00009682 75 12 75 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_183065_96_527_+ FIG00022899 15 6 16 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_183075_208_527_+ FIG00036406 16 5 19 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_183091_77_527_+ FIG01955899 108 16 109 Cellobiose phosphotransferase system YdjC-like protein Beta-Glucoside Metabolism 2.bc T2D_unique_183101_1_527_+ FIG00014000 66 13 66 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_183104_1_527_+ FIG00010675 84 17 85 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_unique_183161_1_499_+ FIG00000038 43 9 44 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_183182_1_527_+ FIG00016514 66 11 67 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_183212_1_527_- FIG00007157 3 2 5 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_183260_1_526_- FIG00108342 10 3 12 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_183266_1_526_+ FIG00002110 76 15 78 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_183287_123_526_- FIG00341289 18 6 19 Prephenate dehydratase (EC 4.2.1.51) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_183310_120_526_+ FIG00000163 110 16 110 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_183319_36_526_+ FIG00001168 11 5 14 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_183363_1_526_+ FIG00000011 26 6 28 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_183368_1_526_+ FIG01260980 21 6 22 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_183399_1_526_- FIG00846773 91 15 93 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_183403_1_526_+ FIG00002354 18 7 27 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_183430_1_390_- FIG00032753 5 2 7 Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine ECF class transporters 345678 T2D_unique_183438_1_367_- FIG00001385 80 13 80 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_183442_1_526_+ FIG00000464 26 6 27 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_183468_1_314_- FIG00000367 21 6 23 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_183469_84_526_- FIG00006691 93 15 94 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_183480_206_526_+ FIG00000235 67 12 67 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_183508_1_526_- FIG01307369 137 19 137 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) Cellulosome 1.x T2D_unique_183509_285_526_+ FIG00074225 52 8 52 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_183537_1_526_- FIG00000013 12 5 13 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_183563_1_162_+ FIG00001088 40 6 40 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_183584_1_526_+ FIG00000877 122 19 122 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_183649_1_312_+ FIG00063189 37 8 38 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_183718_1_526_- FIG00000402 36 9 38 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_183736_1_485_- FIG00044622 122 19 122 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_183741_139_525_- FIG00000132 7 2 8 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_183747_1_525_+ FIG00035175 130 20 131 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_183773_1_520_+ FIG00021289 15 6 19 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_183775_277_525_+ FIG00000015 8 2 9 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_183786_1_525_+ FIG00135025 132 20 132 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_183792_1_525_+ FIG00000414 63 13 64 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_183811_1_525_+ FIG00013156 92 14 93 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_183839_1_525_- FIG00001548 41 10 46 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_183846_1_525_+ FIG00000825 5 3 6 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_183861_89_525_- FIG00048580 107 16 107 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_183898_1_272_- FIG00000738 71 10 71 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_183898_325_525_- FIG00000450 40 7 40 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_183913_179_525_+ FIG00134889 25 6 27 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_183953_1_525_- FIG00000552 3 2 4 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_183976_1_315_- FIG00006463 17 6 19 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_183980_1_396_+ FIG00561498 30 7 31 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_183985_1_525_- FIG00005243 145 20 145 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_184004_1_525_- FIG00000962 48 8 50 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_184005_1_453_- FIG00051439 22 5 23 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_184008_1_525_- FIG00017454 124 19 125 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_184010_1_525_- FIG00000280 36 9 38 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_184020_1_220_- FIG00007658 53 8 54 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_184025_155_445_- FIG00004334 28 5 29 CRISPR-associated protein Cas2 CRISPRs 1 T2D_unique_184043_1_525_+ FIG00060517 15 5 16 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_184088_1_525_+ FIG00049433 24 9 26 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_184105_1_525_+ FIG00023004 15 4 16 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_184136_1_435_+ FIG01239241 7 7 22 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_184146_1_525_- FIG00063189 74 16 88 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_184163_1_525_- FIG00001022 28 9 30 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_184170_1_165_+ FIG00000194 9 4 10 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_184237_1_431_+ FIG00005698 16 3 17 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_184242_1_525_+ FIG00060517 40 8 42 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_184251_266_525_+ FIG00000396 7 3 8 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_184257_1_336_- FIG00000258 34 8 35 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_184273_1_524_- FIG00048839 70 12 71 Alpha-N-acetylglucosaminidase (EC 3.2.1.50) Chitin and N-acetylglucosamine utilization 2 T2D_unique_184283_1_524_+ FIG00000038 12 3 13 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_184289_277_524_- FIG00451095 7 2 9 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_184291_352_524_- FIG00001189 10 2 11 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_184315_8_524_+ FIG00005860 13 5 14 SusD, outer membrane protein Cellulosome 1.x T2D_unique_184323_1_524_+ FIG00001822 5 4 8 Pantothenate:Na+ symporter (TC 2.A.21.1.1) Coenzyme A Biosynthesis A.191 T2D_unique_184324_1_524_- FIG00001269 61 15 62 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_184327_330_524_- FIG00010759 24 5 25 Putative dihydroxyacetone kinase (EC 2.7.1.29), ADP-binding subunit Dihydroxyacetone kinases 3 T2D_unique_184348_1_524_- FIG00000176 52 11 53 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_184358_199_524_+ FIG00000241 9 2 10 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_184361_24_524_- FIG00000717 122 19 124 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_184388_1_524_- FIG00059211 5 3 6 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_184399_1_524_- FIG00000595 28 6 30 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_184405_1_515_+ FIG00014000 85 17 85 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_184417_210_464_- FIG00000477 9 3 11 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_184437_1_524_+ FIG00029916 14 4 16 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_184452_1_325_+ FIG00067681 33 7 35 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_184478_1_300_+ FIG00000645 57 11 59 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_184498_1_524_+ FIG00003394 156 21 156 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_184528_1_229_- FIG00001129 34 6 35 Cobalt-precorrin-6 synthase, anaerobic Cobalamin synthesis 2 T2D_unique_184562_1_524_+ FIG00004170 79 15 81 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_184582_71_524_+ FIG00000494 22 6 25 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_184609_1_524_+ FIG00001904 137 20 137 Outer surface protein of unknown function, cellobiose operon Beta-Glucoside Metabolism 2.bc T2D_unique_184610_1_261_- FIG00019251 16 5 18 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_184616_1_495_+ FIG00043922 136 19 136 alginate biosynthesis protein AlgJ Alginate metabolism 4.xx T2D_unique_184658_323_524_+ FIG00132994 11 3 14 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_184668_246_524_+ FIG00004589 11 4 13 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_184680_1_524_+ FIG00002245 110 18 110 Glycerophosphoryl diester phosphodiesterase, periplasmic (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_184695_33_524_- FIG00000139 5 2 7 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_184807_1_524_- FIG00000025 99 16 100 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_184814_261_524_+ FIG00001182 23 6 25 [NiFe] hydrogenase nickel incorporation protein HypA NiFe hydrogenase maturation 1 T2D_unique_184831_1_423_- FIG00007960 43 9 44 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_184855_1_523_- FIG00000517 4 3 7 Iron-sulfur cluster-binding protein Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_184886_131_523_+ FIG00000412 33 5 34 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_184898_79_486_+ FIG00030042 94 15 94 Poly-gamma-glutamate synthase subunit PgsC/CapC (EC 6.3.2.-) Poly-gamma-glutamate biosynthesis 3 T2D_unique_184962_74_523_+ FIG00561498 71 12 72 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_184972_1_523_+ FIG01260980 9 5 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_185012_1_482_+ FIG00000552 6 4 8 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_185022_1_523_- FIG01260980 15 5 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_185030_350_523_- FIG00002541 21 4 22 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_185031_1_523_- FIG00000116 153 21 153 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_185036_1_200_+ FIG00061313 32 5 33 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_185037_1_295_- FIG00080955 58 10 58 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_185045_1_523_+ FIG00000283 47 11 49 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_185091_1_130_+ FIG00012067 16 3 16 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_185094_1_523_- FIG00016514 151 21 151 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_185100_1_523_+ FIG00006151 11 3 12 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_185101_330_523_- FIG00085033 11 3 12 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_185119_20_472_- FIG00000645 3 3 4 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_185122_1_523_+ FIG00451095 50 11 51 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_185145_1_523_- FIG00000080 51 10 55 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_185146_1_234_+ FIG00000128 16 3 17 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_185151_86_523_+ FIG00003788 108 15 108 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_185173_139_523_+ FIG00002130 93 15 93 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_185201_1_407_- FIG01260980 49 10 51 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_185303_1_523_- FIG00003460 32 7 33 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_185325_1_523_- FIG00000001 31 9 33 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_185338_1_523_+ FIG01260980 15 7 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_185344_1_522_- FIG00001269 73 12 74 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_185402_1_522_+ FIG00046929 20 8 22 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_185414_1_522_+ FIG00026918 79 14 80 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_185482_1_159_- FIG00000212 5 2 6 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_185482_168_522_- FIG00000224 7 3 10 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_185499_1_371_- FIG00000555 21 5 26 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_185506_1_418_+ FIG01304314 102 16 102 CRISPR-associated protein, Csd1 family CRISPRs 1 T2D_unique_185522_309_522_- FIG00018369 21 5 22 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_185541_1_522_- FIG00000102 69 15 70 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_185564_1_319_+ FIG00000159 56 10 57 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_185582_1_522_+ FIG00006955 4 2 6 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_185603_3_522_- FIG00000267 28 9 29 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_185605_1_304_- FIG00000377 25 5 26 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_185640_1_522_- FIG01260980 60 11 62 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_185678_1_435_+ FIG00075702 31 6 33 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_185684_1_223_+ FIG00000036 26 5 27 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_185691_1_522_- FIG00000317 136 20 136 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_185694_114_522_- FIG00016110 87 15 87 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_185713_1_522_+ FIG00000380 15 4 17 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_185742_1_522_- FIG01306622 103 16 104 O-succinylbenzoate synthase (EC 4.2.1.113) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_185759_1_152_+ FIG00000499 14 3 17 4-hydroxybenzoate polyprenyltransferase (EC 2.5.1.39) Ubiquinone Biosynthesis 2.x T2D_unique_185767_1_522_+ FIG00000139 119 18 120 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_185783_1_522_- FIG00001642 22 8 23 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_185807_1_168_+ FIG00023943 3 2 4 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_185810_1_522_- FIG00000101 128 20 128 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_185833_1_522_+ FIG00002847 39 10 41 HflK protein Hfl operon 1.111 T2D_unique_185839_239_522_- FIG00004453 31 7 32 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_185894_1_327_+ FIG00000897 7 2 9 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_185917_39_521_+ FIG00012845 91 16 92 YbbL ABC transporter ATP-binding protein Broadly distributed proteins not in subsystems 1 T2D_unique_185921_1_521_- FIG00000308 10 7 14 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_185926_1_232_+ FIG00000198 35 7 36 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_185937_1_521_- FIG00088067 125 19 125 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_185948_1_521_+ FIG00000445 57 10 70 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_185952_1_162_+ FIG00137739 28 4 28 Positive regulator of Tartrate dehydrogenase/decarboxylase/D-malic enzyme Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_185965_24_521_- FIG00052605 30 8 31 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_185967_1_387_+ FIG00000279 7 2 8 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_185971_1_507_- FIG00058189 45 8 47 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_unique_186014_1_306_- FIG00000482 11 3 12 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_186021_1_194_- FIG00000899 19 4 20 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_186047_1_130_- FIG00012067 8 2 9 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_186048_1_521_+ FIG01260980 157 21 157 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_186052_1_507_+ FIG00000641 8 4 10 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_186078_1_521_- FIG00001469 81 15 82 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_186101_1_521_- FIG00093180 9 2 11 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_186104_1_280_+ FIG01264307 62 10 62 FIG042796: Hypothetical protein EC699-706 1 T2D_unique_186115_269_521_+ FIG00005698 4 2 5 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_186146_13_521_- FIG01304043 4 2 8 Competence/damage-inducible protein CinA CBSS-257314.1.peg.676 4.x T2D_unique_186152_131_521_- FIG00001469 103 15 103 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_186159_258_521_- FIG00081580 4 2 5 Arsenic efflux pump protein Arsenic resistance 1 T2D_unique_186169_1_521_- FIG00001469 13 6 18 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_186182_1_456_+ FIG01276129 119 17 120 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_186191_1_160_- FIG00000043 15 2 16 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_186193_1_412_+ FIG00020897 31 8 33 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_186207_1_459_+ FIG00016514 33 8 34 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_186225_1_521_- FIG01007502 9 2 10 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_186245_80_521_+ FIG00003387 98 14 98 ABC transporter multidrug efflux pump, fused ATP-binding domains ATP-dependent efflux pump transporter Ybh 1 T2D_unique_186246_1_521_- FIG00059426 18 6 19 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_186276_1_521_+ FIG00000441 29 10 31 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_186294_1_159_+ FIG00002716 6 2 7 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_186294_226_521_+ FIG00003406 12 5 15 AmpG permease Recycling of Peptidoglycan Amino Acids 1 T2D_unique_186360_1_521_- FIG00475203 4 3 5 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_186388_281_439_- FIG00001968 12 3 13 PTS system, mannose-specific IIB component (EC 2.7.1.69) Sialic Acid Metabolism 1.x T2D_unique_186401_1_301_- FIG00000212 78 11 78 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_186411_143_521_+ FIG00000834 107 15 107 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_186423_1_430_+ FIG00719736 23 4 24 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_186430_1_520_+ FIG00000308 112 17 116 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_186452_1_520_- FIG00016768 121 20 121 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_186455_315_520_+ FIG00011468 8 3 9 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_186466_1_138_- FIG00008490 28 4 28 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_186477_1_520_- FIG00034851 16 7 17 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_186480_1_201_+ FIG00019251 33 7 40 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_186485_141_520_+ FIG00904859 95 14 95 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_unique_186501_1_520_- FIG00016514 12 4 15 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_186505_1_520_+ FIG00034293 10 3 12 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_186538_1_520_+ FIG00001548 42 9 45 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_186576_19_520_- FIG00001798 30 7 31 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_186606_1_360_+ FIG00013638 7 3 9 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_186617_1_520_+ FIG00044622 116 18 117 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_186647_1_433_+ FIG00007328 37 7 38 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_186666_1_520_- FIG00000476 3 2 5 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_186673_1_192_+ FIG00000365 31 5 31 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_186673_229_520_+ FIG00750555 3 2 5 Dimeric dUTPase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_186686_184_520_+ FIG00001548 20 3 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_186696_1_520_- FIG00000121 9 3 11 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_186700_1_520_+ FIG00001414 109 19 110 Cell division initiation protein DivIVA Cell Division Cluster 1.x T2D_unique_186704_23_520_- FIG00020363 136 19 136 ABC-type tungstate transport system, periplasmic binding protein ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_186711_389_520_- FIG00000372 8 2 9 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_186728_1_520_- FIG00135546 92 14 93 Predicted rhamnogalacturonan lyase in rhamnose utilization cluster L-rhamnose utilization 1 T2D_unique_186734_1_520_- FIG00004172 92 17 92 Response regulator of zinc sigma-54-dependent two-component system Zinc resistance 1.110 T2D_unique_186747_1_170_- FIG00037431 8 2 9 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_186755_1_520_+ FIG00001106 136 20 136 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_186769_1_520_- FIG00437351 17 7 18 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_unique_186780_1_469_+ FIG00000927 18 7 20 Methylmalonyl-CoA mutase (EC 5.4.99.2) Serine-glyoxylate cycle 1 T2D_unique_186781_1_520_+ FIG00048507 136 20 136 Catabolite control protein A HPr catabolite repression system 1 T2D_unique_186797_1_520_- FIG00002968 86 15 87 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_186805_92_520_- FIG00003530 76 14 77 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_186830_1_520_+ FIG01260980 54 14 56 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_186837_1_520_+ FIG00011272 24 7 26 Prolyl endopeptidase (EC 3.4.21.26) EC 3.4.21.- Serine endopeptidase 1 T2D_unique_186852_1_520_+ FIG01260980 129 18 129 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_186861_1_520_+ FIG00000085 38 10 39 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_186900_88_468_+ FIG00000621 8 2 10 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_186903_130_520_+ FIG00000139 12 4 13 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_186922_1_348_- FIG00046929 4 2 6 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_186928_277_520_- FIG01007502 27 5 29 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_186994_1_223_- FIG00007328 12 4 13 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_186996_1_519_+ FIG00122441 142 21 142 Two-component sensor kinase SA14-24 Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_186999_1_519_- FIG00451095 98 17 99 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_187005_1_181_- FIG00016132 13 3 14 putative esterase Alpha-Amylase locus in Streptocococcus 3 T2D_unique_187008_1_509_+ FIG00000001 19 6 22 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_187048_1_519_- FIG00000156 63 11 65 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_187068_1_312_+ FIG00000842 73 12 73 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_187068_316_507_+ FIG00000842 45 7 45 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_187087_1_519_+ FIG00010508 105 17 106 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_187097_30_519_- FIG00000402 119 18 120 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_187109_8_519_- FIG00003174 19 6 20 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_187119_1_519_+ FIG01260980 20 6 22 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_187134_1_519_- FIG00001548 41 7 42 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_187146_1_519_- FIG00000338 54 15 57 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_187187_1_155_+ FIG00000013 10 4 11 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_187198_1_519_+ FIG00001307 98 17 98 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_unique_187200_1_240_- FIG00000372 9 3 10 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_187219_1_203_- FIG00008507 3 2 5 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_187223_65_499_- FIG00000118 19 6 20 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_187262_1_519_- FIG00026750 30 8 33 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_unique_187285_1_519_- FIG00011622 10 5 11 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_187296_1_519_+ FIG00001824 112 18 114 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_187298_1_519_+ FIG01260980 37 9 39 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_187307_1_222_+ FIG00719736 34 6 37 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_187326_380_519_+ FIG00093180 13 3 16 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_187334_371_519_+ FIG00000288 6 2 7 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_187343_1_413_+ FIG00000402 6 4 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_187344_1_298_- FIG00000279 23 4 24 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_187344_368_519_- FIG00001656 28 5 28 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_unique_187346_1_519_+ FIG00006691 12 6 16 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_187348_1_519_- FIG00000001 40 10 42 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_187361_1_519_- FIG00846773 7 3 9 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_187376_1_519_+ FIG00074916 127 19 127 Acetolactate synthase, catabolic (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_187396_1_519_- FIG00451095 132 20 133 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_187412_1_415_- FIG00092725 33 7 35 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Anaerobic respiratory reductases 3 T2D_unique_187435_345_519_+ FIG00000421 16 5 18 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_187441_1_272_- FIG00026918 20 3 22 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_187453_1_519_+ FIG01260980 30 9 31 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_187455_1_206_+ FIG00002011 3 3 5 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_unique_187457_244_519_+ FIG00047414 58 9 58 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_187482_239_519_+ FIG00000015 4 3 6 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_187511_315_519_+ FIG01955899 5 2 6 Cellobiose phosphotransferase system YdjC-like protein Beta-Glucoside Metabolism 2.bc T2D_unique_187526_1_242_- FIG00062547 20 5 21 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_187535_1_519_+ FIG00000571 18 5 21 Signal transduction histidine kinase CheA (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_unique_187540_55_474_- FIG00001636 90 14 90 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_unique_187552_247_518_- FIG00000148 19 3 20 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_187559_1_518_- FIG01954097 8 5 10 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_187576_151_518_- FIG00000368 93 14 93 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_187601_1_518_- FIG00034392 27 8 29 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_187654_266_518_- FIG00000408 10 2 11 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_187685_1_518_+ FIG00004655 56 12 59 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_187696_211_518_+ FIG00013638 67 10 67 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_187699_1_518_- FIG00026918 44 10 46 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_187704_27_518_- FIG00134889 7 3 9 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_187709_1_518_+ FIG00006463 7 4 10 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_187736_1_441_+ FIG00000177 92 15 93 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_187737_67_518_+ FIG00003086 45 11 48 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_187746_1_518_+ FIG00139262 147 21 147 Poly(glycerol-phosphate) alpha-glucosyltransferase (EC 2.4.1.52) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_187756_1_518_- FIG00067681 67 11 69 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_187774_1_518_+ FIG00000402 130 19 130 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_187792_1_374_- FIG00000352 49 10 50 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_187813_1_518_+ FIG00000176 32 5 35 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_187854_22_267_- FIG00000747 68 10 68 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_187856_1_518_+ FIG00000672 33 10 35 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_187863_1_518_- FIG00000343 49 10 51 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_187865_1_318_- FIG00011272 23 5 24 Prolyl endopeptidase (EC 3.4.21.26) EC 3.4.21.- Serine endopeptidase 1 T2D_unique_187898_1_518_+ FIG00000391 17 5 18 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_187920_286_518_+ FIG00000517 5 2 7 Iron-sulfur cluster-binding protein Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_187925_1_518_+ FIG00000480 17 6 19 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_187930_1_518_- FIG00040528 36 10 37 Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282) Quinate degradation 3 T2D_unique_187943_1_518_- FIG00006691 100 18 100 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_187949_1_457_+ FIG00004037 97 16 98 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_187963_1_360_+ FIG00139192 14 6 21 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_188035_210_518_- FIG00031250 16 4 17 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_188053_340_518_- FIG01260980 8 2 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_188104_1_517_- FIG00000069 7 2 9 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_188125_1_282_- FIG00000402 22 6 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_188126_1_517_+ FIG00094176 148 21 148 Urocanate hydratase (EC 4.2.1.49) Hydantoin metabolism 4 T2D_unique_188141_375_517_+ FIG00000381 12 3 13 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_unique_188144_1_517_- FIG00001579 9 4 12 D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13) D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_188145_1_323_- FIG00109688 69 10 70 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_188167_103_366_- FIG00000273 4 2 5 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_unique_188182_1_517_- FIG00000494 20 6 21 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_188194_1_459_- FIG00003472 13 3 14 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_188196_1_517_+ FIG00001548 28 7 30 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_188226_1_517_+ FIG00000088 23 6 24 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_188243_259_517_+ FIG00044622 5 2 7 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_188247_1_517_- FIG00028461 117 18 119 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_188288_1_352_+ FIG00134889 10 4 13 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_188293_1_517_- FIG00000287 131 20 131 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_188304_1_517_- FIG00000793 135 20 135 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_188332_305_517_+ FIG00000333 31 6 32 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_188353_1_517_- FIG00051001 19 9 20 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Biotin biosynthesis 1X T2D_unique_188395_1_357_- FIG00087623 81 14 81 Glycosyltransferase LafA, responsible for the formation of Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_188395_359_517_- FIG00007147 22 3 22 Glycosyltransferase LafB, responsible for the formation of Gal-Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_188404_1_517_+ FIG00001469 48 12 50 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_188434_363_517_+ FIG00041819 35 6 35 N-acylglucosamine 2-epimerase (EC 5.1.3.8) Sialic Acid Metabolism 1.x T2D_unique_188474_1_369_+ FIG00113099 12 5 13 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities CBSS-89187.3.peg.2957 1 T2D_unique_188497_1_517_+ FIG00048014 123 19 124 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_188509_1_517_- FIG00030191 38 9 39 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_188529_1_517_- FIG00036983 126 18 127 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_188549_1_517_- FIG00000555 14 5 15 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_188556_1_282_- FIG00000260 46 9 47 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_188563_1_516_- FIG00046929 80 13 83 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_188564_1_314_+ FIG00000437 29 8 30 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_188569_216_516_- FIG00038726 4 4 6 Ferric siderophore transport system, periplasmic binding protein TonB Hemin transport system 1 T2D_unique_188570_1_516_+ FIG00000001 36 10 37 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_188580_1_516_- FIG00096593 137 20 137 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_188588_1_516_- FIG00002416 27 8 29 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_188589_1_516_+ FIG00010771 46 13 48 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_188601_1_516_+ FIG00075702 63 12 65 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_188604_264_516_+ FIG00018369 5 2 6 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_188633_8_139_+ FIG00002463 29 5 29 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_188635_1_421_+ FIG00099318 84 14 86 RNA polymerase sigma factor SigV Transcription initiation, bacterial sigma factors 1 T2D_unique_188636_1_516_- FIG00000250 7 3 9 L-lysine permease Lysine degradation 1.0 T2D_unique_188651_1_138_- FIG00001145 18 4 20 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_188679_1_516_+ FIG00000456 9 4 12 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_188724_221_516_+ FIG00006424 22 4 23 ADA regulatory protein DNA repair, bacterial 3 T2D_unique_188749_1_516_- FIG00006151 95 15 96 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_188784_1_516_+ FIG00046929 99 14 100 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_188786_1_516_- FIG00000043 104 17 105 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_188796_1_196_+ FIG00035175 24 4 24 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_188799_194_516_- FIG00007960 11 5 13 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_188829_280_516_+ FIG00719736 4 3 5 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_188841_1_479_- FIG01367215 6 2 8 predicted xylose isomerase Xylose utilization 1 T2D_unique_188849_23_516_+ FIG00846773 12 6 17 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_188854_307_516_- FIG00001712 15 3 16 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_188863_1_516_+ FIG00004764 28 8 30 Ammonium transporter Ammonia assimilation 1 T2D_unique_188867_1_380_- FIG00031969 67 10 68 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_188901_93_516_- FIG00000088 34 7 36 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_188909_1_367_- FIG00032749 26 5 27 Protein YicC CBSS-323097.3.peg.2594 1 T2D_unique_188914_1_516_- FIG00019212 8 4 10 Cobalt-precorrin-6x reductase (EC 1.3.1.54) Cobalamin synthesis 2 T2D_unique_188926_384_516_+ FIG00561498 15 3 15 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_188927_1_516_- FIG00135025 36 10 38 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_188991_1_516_+ FIG00016663 7 2 9 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_188999_147_516_+ FIG00008572 38 7 39 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_189091_1_516_+ FIG00003881 10 2 11 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_189097_1_319_+ FIG00000376 37 8 38 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_189124_377_515_- FIG01260980 23 5 24 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_189139_198_515_+ FIG00041038 66 11 67 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_189140_1_436_- FIG00032753 98 17 98 Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine ECF class transporters 345678 T2D_unique_189155_1_515_- FIG00000168 48 8 49 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_189162_1_515_+ FIG00000088 39 10 41 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_189170_1_464_+ FIG00000113 29 8 31 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_189180_1_368_+ FIG00041382 33 8 34 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_189185_1_515_+ FIG00000080 47 10 50 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_189201_1_182_+ FIG00005089 11 5 12 Spore cortex-lytic enzyme, lytic transglycosylase SleB Spore germination 1 T2D_unique_189203_133_515_+ FIG00014556 3 3 4 DNA sulfur modification protein DndD DNA phosphorothioation 1 T2D_unique_189221_1_243_+ FIG00001643 27 5 29 Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_189226_237_515_+ FIG00132787 4 4 6 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_189232_1_515_- FIG00001469 76 13 77 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_189244_1_203_+ FIG00022899 4 2 5 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_189289_37_515_+ FIG00001893 41 9 42 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_189294_1_327_- FIG00001548 93 13 93 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_189300_1_299_+ FIG00000206 31 7 36 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_189303_1_515_+ FIG00007957 3 4 6 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_189305_1_184_- FIG00000825 10 3 11 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_189308_1_515_- FIG00006542 19 8 21 FIG006542: Phosphoesterase CBSS-257314.1.peg.676 4.x T2D_unique_189313_1_317_+ FIG00000825 60 9 60 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_189317_1_394_+ FIG00009149 6 2 7 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_189318_1_515_+ FIG00000280 61 15 62 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_189342_69_515_- FIG00140053 102 16 103 PTS system, fructose- and mannose-inducible IIA component (EC 2.7.1.69) Fructose and Mannose Inducible PTS 2 T2D_unique_189344_1_515_+ FIG00001635 16 6 17 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_189348_1_515_+ FIG00008348 125 19 125 Predicted transcriptional regulator of N-Acetylglucosamine utilization, GntR family Chitin and N-acetylglucosamine utilization 2 T2D_unique_189350_241_515_+ FIG00003394 56 10 57 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_189352_303_515_- FIG00042616 6 3 7 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_189359_1_515_+ FIG00001561 22 6 23 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_189360_1_515_+ FIG00000287 39 11 40 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_189371_343_515_+ FIG00007086 9 2 10 Substrate-specific component CbiM of cobalt ECF transporter ECF class transporters 345678 T2D_unique_189387_1_515_- FIG00012945 110 19 110 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_189408_166_515_- FIG00047056 8 3 10 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_189434_115_515_- FIG00074225 6 4 8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_189445_9_515_- FIG00024930 39 8 40 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_189504_108_515_+ FIG00022976 54 12 55 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_189511_1_309_- FIG00059413 5 3 7 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL Dihydroxyacetone kinases 3 T2D_unique_189516_1_515_- FIG00000212 20 4 21 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_189534_1_219_+ FIG01266244 16 4 18 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_189568_1_515_- FIG00000380 42 10 44 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_189578_1_515_+ FIG00024930 40 11 41 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_189582_1_515_- FIG00000680 138 20 138 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_189590_1_515_+ FIG00048014 50 12 52 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_189591_1_515_+ FIG00543846 127 18 127 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_189596_1_515_- FIG00002034 101 16 102 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_189621_1_515_- FIG00000011 6 2 7 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_189622_1_228_+ FIG00001522 62 9 62 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_189634_1_515_- FIG00000450 113 19 113 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_189638_1_395_- FIG00000414 36 10 37 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_189669_50_514_- FIG00014849 26 5 27 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_189763_1_237_- FIG00067681 53 8 53 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_189763_303_514_- FIG00067681 36 6 37 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_189776_1_514_+ FIG00133515 12 3 14 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_189808_1_514_+ FIG00000414 134 20 134 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_189847_1_514_+ FIG01260980 70 11 71 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_189884_1_514_+ FIG00034392 112 18 115 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_189906_1_458_+ FIG00045144 61 13 63 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_189914_377_514_+ FIG00001550 10 3 11 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_189923_1_356_- FIG00340292 8 3 9 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_189924_1_514_- FIG00001166 58 11 60 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_189937_172_514_+ FIG00000356 84 13 84 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_189944_1_514_- FIG00000022 6 4 8 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_unique_189972_347_514_+ FIG00034392 34 5 34 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_189978_127_514_- FIG00080955 6 2 7 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_189980_1_350_+ FIG00023943 99 14 99 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_189992_1_514_+ FIG00000139 5 3 9 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_190040_1_382_- FIG00000824 76 13 77 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_190042_350_514_+ 9 3 10 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_190044_1_354_- FIG00000402 14 5 15 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_190056_1_136_- FIG00035175 3 2 4 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_190077_1_514_+ FIG00008941 58 11 59 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_190095_268_514_- FIG00018392 64 10 64 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_unique_190100_1_365_- FIG00000264 41 8 42 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_unique_190112_1_392_- FIG00000782 6 3 7 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_190124_195_514_+ FIG00074196 9 2 10 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_190127_1_514_+ FIG00002489 70 12 78 Spore germination protein GerKA Spore germination 1 T2D_unique_190154_157_514_- FIG00000858 34 8 35 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_unique_190181_1_229_- FIG00000260 17 5 18 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_190190_1_431_- FIG00000314 24 6 26 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_190193_128_514_- FIG00138538 18 7 19 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_190203_1_514_+ FIG01260980 7 3 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_190217_1_474_+ FIG00075970 109 18 109 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_190221_226_514_+ FIG00001198 18 5 19 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_190223_1_514_+ FIG00001198 65 11 66 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_190226_1_134_- FIG01304601 6 2 6 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_190226_203_514_- FIG00000782 26 6 28 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_190232_1_183_+ FIG00018457 3 2 4 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_190240_190_513_+ FIG00006700 6 3 7 RNA binding protein, contains ribosomal protein S1 domain Cell division-ribosomal stress proteins cluster 1 T2D_unique_190271_1_173_- FIG00010818 17 4 18 L-serine dehydratase, beta subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_190272_1_513_- FIG00010194 21 7 22 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_190280_1_513_- FIG00001088 12 3 14 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_190327_1_513_+ FIG00001469 16 4 18 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_190377_1_220_+ FIG00004014 19 5 20 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_190419_1_513_- FIG00005237 152 21 152 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_190430_331_513_+ FIG00000242 4 2 7 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_190454_1_513_+ FIG00041038 101 15 105 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_190519_77_513_+ FIG00002914 20 7 23 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_190528_309_513_- FIG00001676 5 2 6 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_190535_164_513_- FIG00010675 13 4 14 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_unique_190547_1_370_- FIG00000840 94 14 94 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_190563_1_513_+ FIG00010524 18 5 22 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_190577_67_438_+ FIG00000130 28 7 29 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_190582_1_365_- FIG00031250 46 10 48 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_190587_1_513_- FIG00074225 108 18 108 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_190590_271_513_- FIG00000139 25 6 27 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_190600_1_513_- FIG00000116 136 21 136 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_190604_1_513_- FIG00000268 48 12 49 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_190615_1_513_- FIG01239241 97 15 98 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_190621_1_513_+ FIG00000990 139 20 139 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_190654_1_513_- FIG00001088 11 4 16 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_190662_1_513_- FIG00017190 7 3 9 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_190678_1_513_- FIG00000032 21 7 43 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_190689_182_513_+ FIG00132839 40 8 41 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_190699_331_513_+ FIG00000421 21 5 22 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_190704_95_513_+ FIG00046929 20 6 22 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_190707_1_513_+ FIG00002470 27 6 28 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_190712_370_513_- FIG00000434 20 4 24 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_190742_1_417_- FIG01276112 11 5 14 Xylose ABC transporter, permease component Xylose utilization 1 T2D_unique_190747_136_513_- FIG00000986 63 11 64 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_190772_1_475_+ FIG00000395 22 7 23 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_190778_64_513_- FIG00000185 11 4 12 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_190790_284_513_+ FIG00020613 17 5 20 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_190800_1_512_+ FIG01306479 50 10 50 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_190812_1_512_+ FIG00138258 81 15 82 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_190814_1_512_+ FIG00023004 33 8 34 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_190827_1_512_- FIG00001809 135 19 135 S-formylglutathione hydrolase (EC 3.1.2.12) Glutathione-dependent pathway of formaldehyde detoxification 1 T2D_unique_190828_1_341_- FIG00088533 14 6 15 Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Cobalamin synthesis 2 T2D_unique_190858_247_512_+ FIG00000578 18 5 19 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_190864_1_440_- FIG00000474 3 3 5 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_190876_1_512_- FIG00000381 93 17 94 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2) Isoprenoid Biosynthesis 2.x T2D_unique_190900_1_512_- FIG00135469 25 5 27 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_190905_131_310_+ FIG00006632 20 4 21 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_unique_190917_171_512_- FIG00846773 75 11 75 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_190925_55_432_+ FIG00062547 65 10 67 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_190931_1_512_+ FIG00000345 119 18 120 Ferrochelatase, protoheme ferro-lyase (EC 4.99.1.1) Biogenesis of c-type cytochromes 1.1 T2D_unique_190957_335_512_+ FIG00001676 11 3 13 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_190963_1_512_- FIG00000824 142 20 142 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_190997_212_512_- FIG00023946 8 3 10 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_191023_1_512_+ FIG00046929 106 17 106 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_191031_1_512_+ FIG00074225 46 11 53 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_191063_1_512_+ FIG00066643 43 9 45 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_191073_1_247_+ FIG00000343 34 6 37 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_191083_1_512_- FIG00129130 13 6 14 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_191092_1_512_- FIG00001548 16 5 17 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_191133_94_261_- FIG00122134 39 6 39 Malolactic regulator Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_191141_147_512_- FIG01546819 5 2 6 TPP-requiring enzyme co-localized with putative O-antigen rfb gene cluster Acetoin, butanediol metabolism 5 T2D_unique_191152_1_512_+ FIG00001647 13 6 18 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_191203_1_512_- FIG00035175 145 20 145 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_191263_1_512_- FIG01260980 17 5 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_191333_1_512_- FIG00000011 123 18 124 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_191343_1_512_+ FIG00000402 10 3 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_191376_312_512_- FIG00066643 3 2 4 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_191382_1_345_+ FIG00093180 8 4 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_191406_71_511_+ FIG00001824 22 5 23 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_191407_1_511_+ FIG00001687 3 2 4 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_191413_1_511_- FIG00001022 3 3 5 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_191414_1_172_+ FIG00000191 25 5 26 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_191436_99_511_- FIG01304998 70 12 72 RND efflux system, membrane fusion protein CmeA Multidrug Resistance Efflux Pumps 1.12 T2D_unique_191467_1_511_- FIG00000156 24 7 27 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_191484_1_511_+ FIG00007339 135 19 135 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_191506_1_222_- FIG00000636 30 7 31 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_191508_1_511_- FIG00066575 8 2 11 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_191514_1_511_+ FIG00019251 10 5 13 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_191531_1_511_- FIG00002414 22 4 22 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_unique_191535_1_511_+ FIG00000672 73 13 76 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_191537_1_511_+ FIG01955774 7 2 8 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_191540_1_511_- FIG00009450 19 6 20 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_191558_1_212_- FIG00028461 20 4 20 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_191560_1_511_+ FIG00003535 144 20 144 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_191613_1_313_+ FIG00133219 6 3 9 Thiamin biosynthesis lipoprotein ApbE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_191625_1_140_- FIG00000539 4 2 5 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_191644_1_511_+ FIG00010508 50 12 51 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_191647_51_511_+ FIG00002803 11 5 13 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_191658_1_511_+ FIG00007694 5 4 6 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_191659_1_226_+ FIG00000578 8 2 9 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_191692_1_204_- FIG00132617 39 7 40 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_191698_1_511_- FIG00046929 126 20 126 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_191731_1_511_- FIG00000343 97 17 98 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_191783_1_511_- FIG00000858 106 16 108 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_unique_191791_1_511_- FIG00135554 10 5 12 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_191795_1_511_- FIG00000494 51 10 53 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_191805_223_511_- FIG00000065 74 11 74 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_191883_1_511_- FIG00001547 8 6 27 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_191898_1_511_- FIG00000069 24 4 24 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_191933_293_511_- FIG00000641 11 3 12 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_191937_1_511_- FIG00000372 86 13 87 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_191945_1_395_- FIG00001088 105 16 105 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_191950_1_266_- FIG00006997 15 2 16 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_191960_1_242_- FIG00026918 4 2 5 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_191961_18_422_- FIG00000985 22 4 23 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_192019_1_510_+ FIG00000116 23 6 26 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_192024_1_510_+ FIG00561498 41 10 43 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_192028_1_510_- FIG00001548 15 5 16 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_192035_335_510_+ FIG00000175 26 5 28 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_192079_1_510_- FIG00136692 128 20 128 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_192095_1_510_- FIG00229199 3 2 7 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_192116_339_510_+ FIG00000221 46 7 46 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_192117_1_510_+ FIG00000824 22 8 23 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_192139_1_270_+ FIG00038726 5 5 7 Ferric siderophore transport system, periplasmic binding protein TonB Hemin transport system 1 T2D_unique_192144_1_510_- FIG00005172 12 6 15 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_192173_1_341_- FIG00057709 3 2 4 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_192181_207_510_+ FIG00005728 80 11 80 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_192184_1_510_+ FIG00080955 25 8 27 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_192190_1_237_- FIG00135742 10 4 11 Ribonuclease HI-related protein Ribonuclease H 1.010 T2D_unique_192196_153_510_- FIG00031250 4 2 6 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_192199_316_510_+ FIG01318398 51 7 51 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_192248_1_510_- FIG00000372 96 15 97 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_192253_1_510_+ FIG00006151 56 13 57 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_192263_1_159_+ FIG00000223 36 5 36 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_192287_1_510_+ FIG00000721 6 3 8 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_192288_51_510_- FIG00085033 11 2 12 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_192289_1_510_- FIG00561498 65 12 68 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_192318_1_510_- FIG00002265 5 4 9 Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE Maltose and Maltodextrin Utilization 1.x T2D_unique_192359_280_510_- FIG00058189 5 2 6 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_unique_192364_1_510_- FIG00000936 125 19 125 Pantothenate kinase (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_192376_1_510_- FIG00016187 11 3 13 Arginine utilization protein RocB Arginine and Ornithine Degradation 1.34 T2D_unique_192380_1_510_- FIG00530360 129 19 130 DUF324 domain-containing protein CRISPR-associated cluster 1 T2D_unique_192385_1_510_- FIG00000036 34 7 36 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_192396_1_362_- FIG00000494 16 3 17 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_192399_1_289_+ FIG00060517 8 2 9 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_192426_1_510_- FIG00002300 39 8 42 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_192443_1_157_+ FIG00041038 4 3 5 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_192449_1_510_- FIG00035175 130 20 131 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_192460_277_510_- FIG00008294 3 2 4 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_192481_1_510_+ FIG00000114 24 6 25 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_192514_1_510_- FIG00009194 44 10 47 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_192521_39_510_- FIG00000258 58 12 59 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_192528_154_510_- FIG00719736 24 6 25 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_192534_1_171_+ FIG00026918 11 3 14 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_192539_248_510_- FIG00001440 39 6 41 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_192549_89_510_+ FIG00000391 8 2 9 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_192559_1_509_+ FIG00009194 14 5 15 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_192566_1_509_+ FIG00000212 131 20 131 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_192572_1_509_- FIG00032749 33 8 37 Protein YicC CBSS-323097.3.peg.2594 1 T2D_unique_192608_1_145_+ FIG00000191 23 4 24 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_192624_1_509_- FIG00229257 4 2 6 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_192651_140_403_+ FIG00000101 3 2 4 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_192655_1_299_- FIG00000139 7 2 8 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_192655_308_509_- FIG00000088 26 6 27 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_192679_1_509_- FIG00093180 118 17 118 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_192685_1_168_- FIG00001893 41 6 41 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_192721_1_509_+ FIG00051439 30 7 32 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_192741_1_430_+ FIG01016270 7 4 15 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_192775_1_258_- FIG00012067 14 5 16 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_192792_1_245_- FIG00000439 31 6 31 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_192794_1_509_- FIG00070513 72 15 73 phosphotransbutyrylase (EC 2.3.1.19) Acetyl-CoA fermentation to Butyrate A T2D_unique_192843_1_509_- FIG00000207 31 9 32 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_192848_1_292_+ FIG00001269 29 7 31 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_192852_13_509_- FIG00000641 14 4 17 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_192861_1_509_- FIG00000620 28 6 31 Phosphoheptose isomerase (EC 5.3.1.-) CBSS-160492.1.peg.550 1 T2D_unique_192885_1_145_- FIG00001469 3 2 4 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_192907_148_363_+ FIG01290653 18 5 18 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_192914_1_509_- FIG00000309 56 13 57 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_192937_1_509_- FIG01260980 34 8 35 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_192961_1_430_- FIG00005237 60 11 62 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_193011_1_509_+ FIG00000134 116 17 117 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_193012_104_397_- FIG00006940 46 9 49 Sugar phosphate isomerases/epimerases family protein YcjR Maltose and Maltodextrin Utilization 1.x T2D_unique_193015_1_326_- FIG00002049 63 10 63 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_193015_348_509_- FIG00455853 34 6 34 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_193048_197_509_+ FIG00000614 25 6 26 Ornithine cyclodeaminase (EC 4.3.1.12) Arginine and Ornithine Degradation 1.34 T2D_unique_193086_195_509_+ FIG00000038 51 9 52 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_193147_1_221_- FIG00000402 36 6 37 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_193151_1_508_- FIG00000352 80 15 81 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_193177_379_508_+ FIG00009682 12 4 13 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_193184_1_508_+ FIG00001076 54 13 55 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_193197_1_508_+ FIG00000672 43 10 45 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_193203_1_508_- FIG00000107 45 9 48 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_193210_1_508_- FIG01260980 33 10 34 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_193213_1_508_+ FIG00000011 10 5 13 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_193280_1_508_+ FIG01304601 117 19 117 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_193282_1_417_+ FIG00002194 29 7 31 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_193298_1_508_+ FIG00719736 51 10 52 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_193319_1_508_+ FIG00000343 15 5 17 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_193320_1_263_- FIG00000388 31 5 33 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_193320_264_508_- FIG00000897 5 2 7 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_193331_1_455_+ FIG00012692 22 4 24 Site-specific tyrosine recombinase Proteasome bacterial 1 T2D_unique_193345_1_508_+ FIG00002034 21 6 22 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_193353_1_137_- FIG00137847 20 3 20 Iron compound ABC uptake transporter ATP-binding protein Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_193354_1_508_- FIG01306479 8 5 9 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_193355_1_476_- FIG00011114 66 12 68 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_193364_1_369_- FIG00000494 8 4 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_193366_1_508_- FIG00007960 138 20 138 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_193381_288_508_- FIG01290653 13 4 15 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_193388_1_213_+ FIG00001036 32 5 33 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_193389_1_508_+ FIG00000450 9 2 10 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_193391_92_508_- FIG00015381 19 4 21 Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_193399_5_274_- FIG00000333 24 7 25 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_193422_1_508_- FIG00000709 40 11 57 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) Periplasmic disulfide interchange 1 T2D_unique_193433_1_160_- FIG00003756 40 6 40 Maltose-6'-phosphate glucosidase (EC 3.2.1.122) Maltose and Maltodextrin Utilization 1.x T2D_unique_193441_364_508_- FIG00000146 31 5 31 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_193448_1_508_- FIG00001824 74 14 75 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_193462_1_508_+ FIG00003506 140 20 140 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_193510_1_508_- FIG00000863 123 19 123 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_193567_1_505_+ FIG00000121 36 7 37 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_193573_1_198_+ FIG00002299 5 2 7 Ascorbate-specific PTS system, EIIB component (EC 2.7.1.69) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_193600_1_508_- FIG01260980 3 3 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_193623_59_508_- FIG00019251 21 7 27 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_193632_1_222_+ FIG00000433 12 5 16 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_193655_1_508_+ FIG00001029 129 18 131 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_193672_128_508_- FIG00000084 49 10 51 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_193683_36_507_- FIG00000464 50 11 51 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_193724_1_507_+ FIG00000402 10 7 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_193747_1_176_+ FIG00000086 12 3 13 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_193753_1_507_- FIG00003086 23 6 25 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_193754_1_507_+ FIG00000224 7 4 8 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_193771_82_507_- FIG00135554 94 16 95 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_193796_1_507_- FIG00000315 65 13 66 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_193797_1_507_- FIG00000121 81 15 82 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_193890_1_507_+ FIG00014596 126 18 126 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_193911_1_292_+ FIG00041382 83 12 83 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_193959_1_507_+ FIG00000122 112 18 113 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_193966_1_269_- FIG00003845 27 5 27 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_193967_1_507_+ FIG00000151 58 11 73 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_193992_1_208_- FIG00000445 33 6 34 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_193995_1_476_- FIG00000695 24 6 25 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_193998_97_507_- FIG00048580 21 6 22 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_194006_1_507_- FIG00000594 13 5 17 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_194011_1_378_+ FIG00049915 50 9 52 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_194016_1_377_+ FIG00006151 20 6 21 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_194018_1_507_+ FIG00521220 4 7 23 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_194023_1_359_+ FIG00002177 78 12 79 N-acetylglucosamine-6P-responsive transcriptional repressor NagC, ROK family Chitin and N-acetylglucosamine utilization 2 T2D_unique_194042_262_507_- FIG00076542 7 3 8 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_194046_1_507_+ FIG00001642 5 4 7 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_194068_122_507_+ FIG00000288 87 14 87 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_194079_1_507_+ FIG00000404 13 3 14 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_194090_51_507_- FIG00000350 6 4 8 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_194092_1_507_- FIG00001548 13 5 14 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_194096_190_507_- FIG00059426 71 11 71 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_194115_1_339_- FIG00004413 28 7 29 Pantothenate kinase type II, eukaryotic (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_194119_1_507_- FIG00000173 20 6 24 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_194138_153_507_+ FIG00011659 12 3 15 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_194153_377_507_+ FIG00000185 5 3 6 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_194154_1_338_+ FIG00022300 11 4 14 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_194171_1_397_+ FIG00000185 97 15 97 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_194205_118_507_- FIG00049915 37 9 38 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_194217_1_492_+ FIG00008370 135 19 135 Creatinine amidohydrolase (EC 3.5.2.10) Creatine and Creatinine Degradation 4.0 T2D_unique_194228_1_135_+ FIG00000352 24 4 25 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_194233_1_506_- FIG00138209 21 8 24 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_194285_120_506_+ FIG00003251 24 6 25 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_194291_1_506_+ FIG00004037 8 5 20 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_194302_1_506_+ FIG00000951 147 20 147 Proline iminopeptidase (EC 3.4.11.5) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_194308_1_506_+ FIG00561498 6 2 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_194313_1_336_- FIG00016836 84 13 84 Transcription termination protein NusB Transcription factors bacterial 1 T2D_unique_194318_90_506_+ FIG00000011 7 3 8 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_194339_162_506_+ FIG00001882 15 6 16 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_194359_1_257_- FIG00000277 71 10 71 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_194360_1_399_- FIG00003439 6 4 8 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_194374_1_506_+ FIG00000641 27 6 28 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_194381_1_449_+ FIG00000367 37 12 38 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_194386_1_506_+ FIG00002385 131 19 131 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_194402_1_506_- FIG00000147 45 12 46 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_194440_1_506_+ FIG00000380 15 4 17 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_194457_1_506_- FIG00003520 7 4 8 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_194472_1_342_+ FIG01303880 58 11 59 Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex (EC 1.8.1.4) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_194483_1_506_+ FIG00022976 7 5 16 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_194542_1_506_- FIG00006691 3 4 6 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_194543_1_367_- FIG00000364 89 13 91 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) Coenzyme A Biosynthesis A.191 T2D_unique_194558_16_506_- FIG00008591 6 3 7 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_194661_1_256_- FIG00000207 23 5 24 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_194670_1_506_+ FIG00000085 114 18 114 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_194686_1_506_- FIG00000834 131 20 131 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_194713_1_427_+ FIG00060517 33 8 35 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_194743_1_506_- FIG01583289 25 7 28 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_194748_73_506_- FIG00006764 32 9 34 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_194753_1_506_- FIG00034851 84 15 85 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_194756_1_224_+ FIG00001980 25 5 27 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_194768_1_506_+ FIG00002268 71 13 74 ATP-dependent DNA ligase (EC 6.5.1.1) clustered with Ku protein, LigD DNA Repair Base Excision 4 T2D_unique_194788_315_506_+ FIG00000146 12 4 14 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_194792_1_506_+ FIG00002968 3 4 7 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_194818_1_506_- FIG00146664 37 9 39 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_194824_218_506_- FIG00001687 72 10 72 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_194837_1_506_+ FIG00001106 76 13 77 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_194871_44_505_+ FIG01956071 20 5 21 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_unique_194875_130_505_+ FIG00000069 22 7 23 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_194896_1_505_- FIG00000001 78 15 79 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_194901_1_505_- FIG00001618 4 6 11 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_194905_1_505_- FIG00003394 117 20 117 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_194908_1_505_- FIG00120441 11 2 14 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_194913_1_505_- FIG00711303 12 3 13 Guanine-hypoxanthine permease Purine Utilization 1 T2D_unique_194939_1_505_+ FIG00000131 24 7 38 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_194963_1_432_+ FIG01296669 19 4 20 Diaminobutyrate-pyruvate aminotransferase (EC 2.6.1.46) Ectoine biosynthesis and regulation missing T2D_unique_194980_1_245_- FIG00116638 46 9 46 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_194985_23_505_+ FIG00000680 27 8 28 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_194994_1_231_+ FIG00026918 18 4 20 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_194994_245_505_+ FIG00000095 8 3 9 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_195004_1_366_+ FIG00000392 51 9 53 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_195007_325_505_+ FIG01290653 8 3 9 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_195009_1_350_+ FIG00012746 10 3 16 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_195013_1_505_- FIG00074225 17 6 19 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_195026_1_227_+ FIG00134889 57 9 57 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_195043_1_505_+ FIG00052605 127 20 127 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_195079_1_505_+ FIG00010442 132 19 132 Transmembrane component BL0694 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_195086_1_505_+ FIG00002034 9 3 11 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_195098_1_505_+ FIG00040890 143 20 143 tRNA-dependent lipid II-Ala--L-alanine ligase tRNA-dependent amino acid transfers 1 T2D_unique_195099_317_505_- FIG00007039 6 2 7 Multiple sugar ABC transporter, membrane-spanning permease protein MsmG Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_195102_1_345_+ FIG00000840 86 14 86 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_195110_328_505_+ FIG00051439 3 2 3 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_195114_1_287_+ FIG00135025 44 8 46 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_195126_1_505_+ FIG00001385 6 4 8 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_195131_150_505_+ FIG00021517 60 9 63 Cell division protein FtsQ Cell Division Cluster 1.x T2D_unique_195135_1_408_- FIG00003394 76 12 77 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_195137_1_505_+ FIG00018035 79 13 80 Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter ECF class transporters 345678 T2D_unique_195153_32_505_- FIG00459778 29 6 31 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_195169_1_215_- FIG00016566 8 3 10 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_195179_1_175_- FIG00000350 6 2 7 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_195182_1_505_- FIG00001469 10 2 12 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_195189_1_505_+ FIG00000402 94 16 95 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_195225_222_505_- FIG00000474 14 6 15 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_195230_1_505_+ FIG00002020 31 8 33 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_195243_1_226_- FIG00018865 26 5 27 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_195243_230_505_- FIG00002049 68 11 68 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_195268_1_505_+ FIG00041038 10 3 13 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_195272_1_505_+ FIG00003984 103 16 103 D-serine/D-alanine/glycine transporter Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_195305_1_480_- FIG00120441 55 10 56 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_195308_1_150_+ FIG00002541 34 6 34 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_195308_179_505_+ FIG00133325 80 12 80 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_195337_1_443_+ FIG01260980 16 5 17 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_195384_1_260_- FIG00000015 7 2 8 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_195399_367_505_+ FIG00000047 24 5 24 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_195401_1_505_+ FIG00018392 31 7 33 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_unique_195463_193_504_- FIG00001635 27 7 28 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_195479_1_504_- FIG00000480 73 14 74 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_195545_251_504_+ FIG00451095 35 7 37 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_195589_1_504_+ FIG00135025 18 8 20 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_195602_1_134_- FIG00037431 5 3 7 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_195635_1_276_+ FIG00001307 64 9 65 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_unique_195647_1_268_+ FIG00003751 7 3 8 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_195699_1_270_+ FIG00093180 6 2 8 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_195707_1_245_- FIG00000437 9 3 11 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_195714_1_504_- FIG00109688 21 8 22 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_195732_1_504_- FIG00000377 126 19 127 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_195733_227_504_- FIG00003439 28 5 30 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_195736_1_357_+ FIG00000205 11 4 13 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_195812_1_504_+ FIG01228918 15 7 21 ErfK/YbiS/YcfS/YnhG family protein Copper homeostasis 12 T2D_unique_195815_1_324_- FIG00000159 68 11 69 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_195845_156_504_- FIG00000182 75 13 75 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_195886_1_504_- FIG00041038 6 3 8 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_195887_1_454_+ FIG00001192 6 9 44 Paraquat-inducible protein B Hemin transport system 1 T2D_unique_195927_1_504_+ FIG00052300 45 11 46 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_195929_1_504_+ FIG00132839 69 13 70 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_195942_1_504_- FIG00001882 128 19 128 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_195974_1_504_- FIG00455853 75 16 76 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_196029_230_503_- FIG00000283 17 6 18 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_196031_254_503_+ FIG00002412 24 7 25 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_unique_196045_248_503_- FIG00132770 7 3 8 Prephenate and/or arogenate dehydrogenase (unknown specificity) (EC 1.3.1.12)(EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_196057_1_469_+ FIG00000147 19 8 23 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_196079_1_503_+ FIG00086220 5 3 6 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_196139_339_503_+ FIG00008507 8 2 9 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_196149_1_503_+ FIG00000343 139 20 139 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_196159_1_503_- FIG00060517 17 5 19 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_196163_1_503_+ FIG00621886 17 7 20 Putative arylsulfate sulfotransferase (EC 2.8.2.22) Biogenesis of c-type cytochromes 1.1 T2D_unique_196181_1_503_- FIG01260980 10 5 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_196204_1_187_- FIG00000159 16 5 17 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_196204_352_503_- FIG00000264 8 2 10 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_unique_196211_1_503_+ FIG00009894 134 20 134 Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine ECF class transporters 345678 T2D_unique_196236_1_352_- FIG00034704 90 13 90 UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase WaaW (EC 2.4.1.-) LOS core oligosaccharide biosynthesis 1.x T2D_unique_196239_1_503_+ FIG00018699 3 2 4 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_196272_1_228_- FIG00007714 35 5 35 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_196277_219_503_- FIG00453259 26 7 27 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_196289_1_503_- FIG00000539 10 2 11 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_196332_1_503_- FIG00000113 98 18 107 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_196337_1_503_+ FIG00001385 15 4 16 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_196341_1_503_- FIG00000140 64 12 65 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_196368_1_503_+ FIG00001062 24 6 25 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_unique_196378_1_503_+ FIG00006955 29 11 33 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_196385_1_503_+ FIG00451095 86 13 87 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_196389_1_503_- FIG00009194 115 16 116 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_196394_89_439_+ FIG00001385 11 5 13 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_196413_1_503_- FIG00000085 73 12 74 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_196417_1_493_+ FIG00000756 30 7 32 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_unique_196426_1_482_+ FIG00000298 121 19 121 GTP-binding protein EngB Universal GTPases 2 T2D_unique_196459_1_503_- FIG00001548 10 5 12 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_196475_1_503_+ FIG00001647 8 5 9 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_196481_1_503_- FIG00561498 32 7 33 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_196484_1_402_- FIG00000352 73 13 74 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_196521_1_206_+ FIG00135315 21 4 22 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_196527_1_503_- FIG00023004 4 2 10 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_196536_74_503_+ FIG00001020 10 6 12 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_196546_198_503_+ FIG00006235 13 5 14 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_unique_196562_1_503_+ FIG00001020 89 16 90 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_196576_1_503_- FIG01304229 118 18 118 MSM (multiple sugar metabolism) operon regulatory protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_196577_52_503_+ FIG00000263 58 11 60 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_196585_1_268_- FIG00075970 5 2 7 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_196588_1_434_- FIG00000177 70 14 70 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_196592_1_503_- 4 4 9 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_196610_1_503_+ FIG00000043 39 9 43 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_196613_1_502_- FIG00000111 136 20 136 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_196668_1_502_- FIG00000404 15 7 17 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_196675_1_502_- FIG00001548 68 11 70 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_196676_1_502_+ FIG00001635 29 9 33 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_196713_1_392_+ FIG00010600 17 4 18 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_196715_238_502_+ FIG00059124 8 2 9 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_196755_1_502_+ FIG00000025 66 14 67 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_196756_1_502_+ FIG00001547 5 3 9 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_196771_1_366_+ FIG00000221 34 6 35 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_196776_1_502_+ FIG00000421 38 9 39 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_196778_1_502_+ FIG00000365 93 16 94 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_196780_1_502_- FIG00000575 27 10 30 L-aspartate oxidase (EC 1.4.3.16) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_196790_329_502_- FIG00004021 11 4 12 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_196799_1_441_- FIG00073301 3 2 4 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_196800_145_502_- FIG00000089 22 7 24 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_196838_1_502_- FIG00000522 23 8 24 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_196841_1_502_- FIG00001676 27 6 28 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_196844_1_336_- FIG00000377 89 13 89 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_196857_1_502_- FIG00085033 13 5 14 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_196862_63_502_+ FIG00139491 96 16 96 NAD-reducing hydrogenase subunit HoxE (EC 1.12.1.2) Hydrogenases 2 T2D_unique_196889_1_502_+ FIG00018369 94 15 95 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_196896_81_502_- FIG00006699 14 3 16 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_unique_196902_92_433_+ FIG00000289 13 4 14 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_196907_38_502_- FIG00002746 92 15 94 Chromosome (plasmid) partitioning protein ParB Cell Division Subsystem including YidCD 1 T2D_unique_196929_1_502_+ FIG00016888 32 7 34 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_196932_1_449_- FIG00000040 74 14 76 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_196953_1_502_+ FIG00001145 122 18 122 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_196956_186_502_- FIG00024851 20 4 22 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_196957_1_502_- FIG00009564 137 20 137 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_196960_1_502_+ FIG01959790 10 5 13 Periplasmic aromatic aldehyde oxidoreductase, FAD binding subunit YagS Purine Utilization 1 T2D_unique_196972_208_502_+ FIG00009564 70 10 70 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_196977_1_502_- FIG00012037 17 4 20 heterodisulfide reductase, iron-sulfur binding subunit, putative Anaerobic respiratory reductases 3 T2D_unique_196998_1_442_+ FIG01954097 6 5 8 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_197043_1_502_+ FIG00000069 121 18 121 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_197045_1_502_+ FIG00000377 107 16 108 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_197060_1_502_+ FIG01307086 4 3 9 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_197065_1_502_- FIG00000456 29 7 31 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_197069_1_502_- FIG00138258 14 3 16 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_197082_1_502_- FIG00140555 54 10 58 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_197098_1_502_+ FIG00011468 5 4 8 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_197104_1_502_+ FIG00000377 17 5 18 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_197111_1_502_+ FIG00023369 18 8 20 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_197113_1_502_+ FIG00000404 27 6 28 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_197123_1_502_- FIG00011537 123 18 124 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_197135_1_502_- FIG00001548 9 4 11 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_197150_1_502_+ FIG00138468 23 6 25 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_197152_125_502_+ FIG00000081 92 14 92 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_197183_1_381_+ FIG00006868 7 4 8 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_197185_1_502_+ FIG00000402 123 19 123 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_197186_1_502_+ FIG00134342 19 6 21 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_197195_1_502_+ FIG00041038 4 3 6 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_197207_1_501_- FIG00005727 68 13 69 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_197237_1_501_+ FIG01260980 46 11 47 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_197271_1_490_+ FIG00000298 64 13 65 GTP-binding protein EngB Universal GTPases 2 T2D_unique_197302_1_501_- FIG00000040 12 6 24 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_197311_255_501_+ FIG00149566 37 6 37 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_197321_1_410_+ FIG00003460 3 2 5 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_197322_1_501_- FIG00561498 11 6 13 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_197334_1_501_- FIG00000601 31 9 32 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_197337_1_501_+ FIG00001113 3 4 4 Urease accessory protein UreD Urease subunits 1.x T2D_unique_197340_1_143_+ FIG00002914 31 5 31 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_197340_172_501_+ FIG00000552 84 13 84 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_197343_1_501_+ FIG00134135 41 9 43 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_197360_1_501_+ FIG00046929 3 4 8 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_197366_1_501_+ FIG00000741 7 4 9 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_unique_197394_1_378_+ FIG00000156 82 14 82 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_197396_1_501_- FIG00085740 66 11 67 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_197400_1_501_- FIG00001670 6 2 7 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_197403_1_248_- FIG00000738 25 6 27 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_197419_1_501_+ FIG00000065 142 20 142 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_197429_353_501_+ FIG00075702 36 5 36 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_197435_337_501_+ FIG00008490 5 2 6 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_197438_1_501_+ FIG01954097 3 4 8 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_197493_1_216_+ FIG00007957 5 3 7 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_197498_40_501_- FIG00003555 6 2 7 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_197517_1_352_+ FIG00001378 14 4 15 N-carbamoylputrescine amidase (3.5.1.53) Polyamine Metabolism 2 T2D_unique_197532_373_501_- FIG00000388 11 2 13 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_197566_1_501_+ FIG00003460 26 7 28 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_197579_1_501_+ FIG00000372 24 7 27 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_197585_181_501_+ FIG01318398 4 2 6 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_197614_27_501_- FIG00000584 45 11 46 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_197628_204_501_+ FIG00000263 32 8 33 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_197632_1_501_- FIG00016514 128 20 128 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_197642_281_501_- FIG00005797 29 6 29 Lipoteichoic acid synthase LtaS Type IIc Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_197687_1_501_- FIG00064110 53 13 54 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_197693_1_501_- FIG00070611 122 20 123 Phosphonate ABC transporter permease protein phnE1 (TC 3.A.1.9.1) ABC transporter alkylphosphonate (TC 3.A.1.9.1) 3 T2D_unique_197696_226_501_- FIG00134167 16 5 17 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_197698_1_501_- FIG00002034 115 18 116 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_197706_1_501_+ FIG00000377 30 8 31 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_197721_1_501_+ FIG00001469 77 15 78 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_197731_69_501_- FIG00000207 21 3 23 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_197757_1_501_+ FIG00000822 54 12 55 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_197760_1_501_- FIG00134889 27 5 29 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_197777_1_500_+ FIG00129130 31 10 33 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_197786_1_271_+ FIG00000085 69 10 70 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_197795_1_205_- FIG00000103 3 2 5 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_197800_322_500_- FIG00000863 18 4 19 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_197804_1_240_+ FIG00000721 5 2 6 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_197817_1_500_- FIG00038343 7 4 9 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_197830_1_345_- FIG00004037 76 11 77 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_197842_1_291_+ FIG00000269 20 5 22 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_197884_1_147_+ FIG00034392 5 4 7 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_197895_1_500_+ FIG00000011 5 5 8 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_197903_1_500_- FIG00002931 13 4 14 Anhydro-N-acetylmuramic acid kinase (EC 2.7.1.-) Recycling of Peptidoglycan Amino Sugars 1 T2D_unique_197909_1_281_- FIG00000080 12 3 14 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_197964_1_500_- FIG00000494 7 4 8 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_197991_1_500_+ FIG00000343 62 13 63 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_198014_1_500_+ FIG00025527 51 10 52 Pyruvate dehydrogenase E1 component beta subunit (EC 1.2.4.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_198027_1_282_- FIG00000025 7 3 9 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_198030_55_500_- FIG00001280 13 5 16 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_198032_1_500_- FIG00000111 64 14 66 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_198038_1_500_+ FIG00000364 109 18 109 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) Coenzyme A Biosynthesis A.191 T2D_unique_198050_1_264_- FIG00003435 35 6 37 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_198053_1_500_- FIG01007502 26 7 28 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_198057_1_500_- FIG00002574 17 6 20 2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37) Phosphonate metabolism 1 T2D_unique_198061_1_391_- FIG00623809 31 5 33 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_198082_1_500_+ FIG00134135 19 7 20 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_198099_1_344_- FIG00007957 31 8 33 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_198109_1_500_- FIG00001366 18 8 19 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_198122_1_500_- FIG00000812 139 20 139 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_198140_1_500_- FIG00000683 133 20 133 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Methionine Biosynthesis 8 T2D_unique_198148_1_199_- FIG00001124 40 7 40 Cystine ABC transporter, periplasmic cystine-binding protein FliY L-Cystine Uptake and Metabolism 6.0 T2D_unique_198163_365_500_+ FIG00000053 35 5 35 LSU ribosomal protein L33p Ribosome LSU bacterial 9 T2D_unique_198169_204_500_+ FIG00001414 5 3 7 Cell division initiation protein DivIVA Cell Division Cluster 1.x T2D_unique_198216_1_152_+ FIG00000539 15 3 15 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_198217_1_500_+ FIG00001528 3 2 8 Cobalt-precorrin-3b C17-methyltransferase Cobalamin synthesis 2 T2D_unique_198242_1_433_- FIG00011468 24 4 25 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_198254_1_500_- FIG00018176 142 20 142 Phospholipid-lipopolysaccharide ABC transporter N-linked Glycosylation in Bacteria 2.0 T2D_unique_198258_1_500_- FIG00001385 133 18 133 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_198259_1_426_+ FIG00000927 7 5 9 Methylmalonyl-CoA mutase (EC 5.4.99.2) Serine-glyoxylate cycle 1 T2D_unique_198291_318_500_- FIG00108342 8 2 9 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_198293_1_500_- FIG00058830 60 13 61 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_198324_1_500_- FIG00003002 126 19 126 HtrA protease/chaperone protein Periplasmic Stress Response 1.1 T2D_unique_198331_166_500_- FIG00000224 16 4 17 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_198334_1_157_+ FIG00012692 36 5 36 Site-specific tyrosine recombinase Proteasome bacterial 1 T2D_unique_198337_1_500_+ FIG00059211 4 3 6 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_198339_1_148_- FIG00000377 34 5 34 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_198373_1_499_+ FIG00041038 120 19 120 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_198392_1_325_+ FIG00000388 29 8 30 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_198426_1_499_+ FIG00000118 12 2 13 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_198433_113_499_- FIG00000897 97 15 97 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_198438_1_499_- FIG00000185 89 15 90 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_198443_1_499_+ FIG00067681 56 12 57 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_198451_1_499_- FIG00007694 4 3 5 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_198464_1_408_+ FIG00077620 29 9 31 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_198486_108_446_+ FIG00037431 81 12 81 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_198487_1_499_+ FIG00000032 92 15 94 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_198508_318_499_+ FIG00002273 22 5 22 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_198519_356_499_+ FIG00055520 9 3 10 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_198534_1_441_+ FIG01304601 108 17 108 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_198553_89_499_- FIG00000177 58 11 59 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_198567_74_499_+ FIG00153929 40 8 48 Duplicated ATPase component of energizing module of predicted pyridoxine-related ECF transporter ECF class transporters 345678 T2D_unique_198571_1_499_+ FIG00000350 12 6 14 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_198574_1_499_+ FIG00132839 76 14 77 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_198584_1_499_- FIG00052605 120 17 121 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_198603_1_499_+ FIG01260980 118 18 119 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_198620_1_499_- FIG00006691 81 14 82 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_198657_1_499_- FIG00455853 113 17 113 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_198663_355_499_- FIG00014000 27 5 27 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_198664_1_499_+ FIG00046929 131 19 131 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_198672_1_499_+ FIG00000606 4 4 7 Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_198677_1_499_+ FIG00003394 6 4 8 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_198684_1_499_+ FIG00000504 89 16 91 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_198688_1_224_- FIG00002354 14 4 16 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_198690_1_499_+ FIG00000085 14 7 16 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_198710_1_499_- FIG00000421 39 9 41 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_198721_1_499_- FIG00036772 49 11 51 Arabinan endo-1,5-alpha-L-arabinosidase (EC 3.2.1.99) L-Arabinose utilization 1 T2D_unique_198730_1_499_+ FIG00011468 91 17 93 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_198737_1_186_- FIG00000372 4 3 5 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_198746_1_499_+ FIG00000080 79 16 80 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_198774_1_499_- FIG00003715 139 20 139 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_198804_33_499_+ FIG00005243 118 17 118 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_198826_1_312_+ FIG00002049 13 4 14 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_198828_1_401_- FIG00028694 32 7 33 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_198843_273_499_+ FIG00000522 11 2 12 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_198848_1_177_- FIG00000680 45 7 45 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_198870_252_499_+ FIG00006151 8 3 9 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_198896_215_499_+ FIG00000551 15 3 16 L-serine dehydratase (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_198903_1_499_+ FIG01010650 20 6 22 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_198915_1_397_+ FIG01260980 18 6 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_198943_1_498_+ FIG00133209 129 20 129 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_198977_1_498_+ FIG00000157 94 14 95 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_199011_1_498_+ FIG00080955 121 18 121 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_199020_1_498_- FIG00002130 138 19 139 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_199021_1_498_+ FIG00000069 15 7 16 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_199088_1_498_+ FIG00041038 33 9 34 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_199092_1_498_+ FIG00000402 33 8 35 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_199126_1_498_+ FIG00003769 4 2 5 Stage III sporulation protein AE Sporulation Cluster III A 1.x T2D_unique_199135_1_498_+ FIG01304149 125 19 126 Glutathione S-transferase domain protein CBSS-89187.3.peg.2957 1 T2D_unique_199182_1_498_- FIG00001020 14 4 18 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_199191_1_282_+ FIG00001635 51 9 63 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_199207_1_498_- FIG00066643 16 4 18 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_199220_1_498_- FIG00000402 31 8 34 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_199221_1_498_- FIG01255877 89 14 90 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_199224_8_498_- FIG00029916 83 13 85 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_199226_263_498_+ FIG00005237 60 9 60 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_199237_1_498_- FIG01260980 121 19 122 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_199256_1_326_+ FIG00077620 23 5 25 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_199257_1_377_- FIG00000510 101 15 101 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_199269_1_225_- FIG00000301 28 7 29 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_199287_342_498_- FIG01010650 31 5 31 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_199293_229_498_- FIG00001188 27 6 28 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_199308_1_374_- FIG00000540 64 12 65 Holo-[acyl-carrier protein] synthase (EC 2.7.8.7) CBSS-176299.4.peg.1292 3 T2D_unique_199334_1_498_- FIG00003086 12 5 13 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_199349_1_492_+ FIG00001676 3 2 4 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_199366_1_183_- FIG01304043 36 5 36 Competence/damage-inducible protein CinA CBSS-257314.1.peg.676 4.x T2D_unique_199400_247_498_+ FIG00475203 71 10 71 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_199404_1_498_- FIG00006889 74 13 75 L-rhamnose isomerase (EC 5.3.1.14) L-rhamnose utilization 1 T2D_unique_199448_1_320_+ FIG00001667 4 3 6 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_199452_1_498_- FIG00000309 113 19 113 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_199467_1_255_+ FIG00000283 20 4 21 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_199500_1_167_- FIG00000114 5 2 6 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_199506_1_497_- FIG00000268 127 18 127 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_199512_1_224_+ FIG00000187 25 5 26 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_199512_241_497_+ FIG00000408 12 5 14 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_199526_1_497_- FIG00000147 10 3 13 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_199534_1_497_+ FIG00000244 108 17 109 Ketol-acid reductoisomerase (EC 1.1.1.86) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_199559_15_497_- FIG00001548 17 6 18 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_199595_1_497_+ FIG00002416 12 6 14 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_199617_1_411_+ FIG00719736 36 7 38 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_199625_142_497_- FIG00459040 18 5 20 Possible fucose ABC transporter, substrate-binding component L-fucose utilization 1 T2D_unique_199628_144_497_- FIG00001834 30 4 31 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_199632_70_497_+ FIG00024930 35 7 36 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_199644_1_497_- FIG00025216 80 15 81 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_199668_1_166_+ FIG00001067 38 5 38 Rubrerythrin Oxidative stress 1.2 T2D_unique_199701_146_497_+ FIG00000279 75 12 76 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_199713_1_446_+ FIG00059124 21 8 23 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48) LMPTP YfkJ cluster 93 T2D_unique_199714_1_254_- FIG00000645 27 6 29 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_199727_121_312_+ FIG00000266 32 6 32 LSU ribosomal protein L28p A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_199742_1_365_- FIG00000402 12 6 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_199761_1_497_+ FIG00001088 65 13 66 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_199766_1_497_+ FIG00000165 77 13 79 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_199770_155_497_+ FIG00001292 95 13 95 D-alanine aminotransferase (EC 2.6.1.21) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_199773_1_497_+ FIG00001385 145 20 145 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_199778_1_497_+ FIG00000897 43 9 45 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_199836_1_497_+ FIG00451095 29 9 30 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_199849_1_497_+ FIG00007079 95 14 97 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_199852_1_497_- FIG00003580 24 9 25 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_199876_1_252_+ FIG00000402 10 2 11 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_199879_366_497_+ FIG00052730 5 2 6 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_199890_98_497_+ FIG00130344 13 3 14 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_199897_1_309_- FIG00017615 70 12 70 Universal stress protein family Universal stress protein family 1 T2D_unique_199899_1_263_+ FIG00007508 15 3 16 Nitrite reductase probable [NAD(P)H] subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_unique_199909_1_497_- FIG00000494 48 11 49 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_199920_1_495_+ FIG00001067 132 20 132 Rubrerythrin Oxidative stress 1.2 T2D_unique_199939_1_497_+ FIG00005112 106 17 106 Trehalose synthase (EC 5.4.99.16) Trehalose Biosynthesis 1.2 T2D_unique_199949_1_497_- FIG00000095 25 6 27 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_199980_63_497_- FIG00132801 12 4 13 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_199982_1_497_- FIG00521220 4 4 7 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_199984_1_497_+ FIG00000280 80 14 81 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_199988_210_497_+ FIG00000241 26 5 27 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_200007_1_435_+ FIG00000659 23 5 25 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_200028_1_497_+ FIG00035175 124 19 125 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_200032_1_302_+ FIG00000863 10 4 11 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_200038_1_456_- FIG00000243 111 16 111 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_200045_114_497_+ FIG00085033 93 14 93 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_200046_1_497_- FIG01266244 88 16 89 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_200075_129_497_+ FIG01290653 8 2 9 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_200079_1_497_- FIG00000245 69 17 70 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_200081_1_497_- FIG00006235 64 13 65 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_unique_200088_1_339_+ FIG00018536 37 7 38 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_200097_1_313_+ FIG00000111 9 4 11 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_200113_1_497_- FIG00623809 51 12 52 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_200115_1_497_+ FIG00000309 16 5 17 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_200128_1_496_+ FIG00007157 32 7 35 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_200129_1_496_+ FIG00003090 55 11 56 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_unique_200130_1_363_- FIG00004410 17 5 19 Aspartate racemase (EC 5.1.1.13) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_200131_1_307_+ FIG00009956 5 3 7 RNA:NAD 2'-phosphotransferase tRNA splicing 1 T2D_unique_200135_1_244_+ FIG00127025 13 3 14 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_200180_1_484_+ FIG00001366 4 2 6 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_200206_1_287_- FIG00001076 36 6 37 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_200209_1_496_+ FIG00000121 30 8 33 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_200233_169_384_- FIG00000193 12 3 14 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_unique_200234_1_496_- FIG00018865 20 6 22 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_200235_73_496_- FIG00000897 7 3 9 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_200237_103_496_- FIG00000402 26 6 27 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_200253_105_496_+ FIG00054459 18 7 20 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_200256_1_454_+ FIG00044735 29 8 30 Aminopeptidase S (Leu, Val, Phe, Tyr preference) (EC 3.4.11.24) EC 3.4.11.- Aminopeptidases 1 T2D_unique_200260_1_496_+ FIG00000412 64 10 65 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_200270_1_496_- FIG00002744 11 6 12 Glycogen branching enzyme, GH-57-type, archaeal (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_200279_1_496_+ FIG00093180 9 4 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_200290_1_496_+ FIG00139192 35 9 37 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_200297_1_204_- FIG00051001 41 7 42 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Biotin biosynthesis 1X T2D_unique_200310_1_496_- FIG00030191 109 18 118 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_200314_1_397_- FIG00002049 67 12 67 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_200322_1_379_+ FIG00001676 4 2 6 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_200327_1_496_+ FIG01260980 18 10 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_200343_1_158_+ FIG00001819 6 3 7 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_200366_1_496_+ FIG00000402 34 8 35 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_200367_125_496_+ FIG00067681 52 9 53 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_200376_1_496_+ FIG00030191 86 16 87 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_200436_1_341_- FIG00130344 84 13 84 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_200467_1_496_- FIG00000380 38 8 39 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_200515_1_496_+ FIG00000402 16 5 18 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_200525_1_496_+ FIG00000710 12 7 39 Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_200536_1_489_+ FIG00475203 110 16 111 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_200571_1_496_- FIG00046929 6 2 8 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_200580_1_496_- FIG00021407 52 10 55 (R)-citramalate synthase (EC 2.3.1.182) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_200586_1_496_- FIG00229199 108 16 109 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_200587_1_221_+ FIG00000413 53 8 53 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_200600_95_496_+ FIG00000017 7 4 9 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_200613_1_496_+ FIG00000025 4 2 6 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_200624_1_496_+ FIG00023946 8 2 9 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_200636_1_439_+ FIG00002515 14 4 22 4-hydroxybenzoyl-CoA thioesterase family active site Ton and Tol transport systems 2 T2D_unique_200642_1_496_+ FIG01255877 43 9 45 Peptide chain release factor 2 Translation termination factors bacterial 1.13 T2D_unique_200667_1_335_- FIG00047509 28 6 29 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_200677_305_475_+ FIG00001489 28 5 29 ribosomal protein L7Ae family protein Transcription factors bacterial 1 T2D_unique_200693_28_330_- FIG00003012 20 6 21 His repressor CBSS-393121.3.peg.1913 1 T2D_unique_200695_1_496_+ FIG00561498 26 7 27 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_200699_1_496_- FIG00031250 35 9 37 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_200707_1_496_- FIG00132801 7 4 10 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_200728_1_436_+ FIG01954097 14 7 17 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_200731_1_496_- FIG00745599 36 8 37 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_200742_1_496_+ FIG00010771 123 18 123 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_200752_1_276_- FIG00000266 13 7 41 LSU ribosomal protein L28p A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_200768_1_495_- FIG00000268 143 20 143 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_200769_1_495_- FIG00000372 96 16 97 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_200770_1_495_- FIG00000039 26 5 29 Translation elongation factor Tu Translation elongation factors bacterial 1.1 T2D_unique_200785_1_495_+ FIG00000990 37 7 38 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_200793_1_248_- FIG00023943 52 9 52 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_200796_1_258_+ FIG00047509 7 2 8 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_200797_147_380_+ FIG00007751 26 4 27 Late competence protein ComC, processing protease Gram Positive Competence 3100 T2D_unique_200814_1_206_- FIG00719736 7 3 8 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_200858_1_495_- FIG00028694 32 8 34 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_200866_231_495_- FIG00000402 15 4 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_200867_1_396_- FIG00000477 31 6 32 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_200908_1_185_- FIG01260980 10 3 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_200949_248_495_+ FIG00085033 16 3 17 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_200950_1_495_- FIG00000402 12 7 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_200973_1_495_+ FIG00001548 20 7 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_200982_72_495_+ FIG00080231 23 6 25 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_200994_1_350_+ FIG00018865 9 7 11 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_200997_119_495_+ FIG00007586 4 3 6 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_201008_1_495_+ FIG01304601 124 19 124 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_201019_1_495_+ FIG00000441 24 8 27 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_201024_1_495_- FIG00001469 25 8 28 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_201030_1_463_+ FIG00132758 115 18 115 Beta-galactosidase large subunit (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_201070_182_495_- FIG00000224 11 2 12 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_201092_1_345_+ FIG01016270 8 3 10 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_201120_1_495_+ FIG01304530 9 3 11 Phage terminase, large subunit Phage head and packaging 1 T2D_unique_201137_200_495_+ FIG00005705 7 2 9 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_unique_201161_1_495_+ FIG00001882 125 18 125 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_201168_1_495_- FIG00041038 112 17 113 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_201193_1_239_- FIG00561498 18 3 19 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_201194_1_495_- FIG00000560 113 17 115 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_201198_1_469_- FIG00079740 14 5 16 Xyloside transporter XynT Xylose utilization 1 T2D_unique_201204_1_495_+ FIG00006151 29 5 31 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_201212_197_495_- FIG00001306 12 4 13 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_unique_201213_1_495_- FIG00011468 74 13 76 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_201235_1_495_+ FIG00004078 29 8 30 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_201274_87_495_+ FIG00000055 103 16 104 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_201328_19_186_+ FIG00003955 7 2 8 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_201333_93_350_- FIG00045144 9 4 11 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_201341_289_495_- FIG00000803 6 2 7 Rod shape-determining protein RodA Peptidoglycan Biosynthesis 1.9 T2D_unique_201345_1_375_- FIG00000412 12 4 14 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_201356_1_495_- FIG00059211 46 10 48 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_201382_50_494_- FIG00008778 16 5 20 Maltose operon transcriptional repressor MalR, LacI family Maltose and Maltodextrin Utilization 1.x T2D_unique_201396_328_494_- FIG00023004 14 3 15 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_201416_1_368_- FIG00001198 98 14 98 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_201417_1_494_+ FIG00000840 16 5 17 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_201421_1_494_+ FIG00001036 12 4 15 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_201442_1_166_+ FIG01304329 13 3 14 Chromosome (plasmid) partitioning protein ParA Cell Division Subsystem including YidCD 1 T2D_unique_201463_1_450_- FIG00000290 8 3 9 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_201480_1_373_- FIG00614545 14 4 15 Acylphosphate phosphohydrolase (EC 3.6.1.7), putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_201488_1_494_- FIG00044622 75 11 76 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_201492_229_494_- FIG00000194 22 5 23 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_201502_1_403_+ FIG00231261 6 4 9 Two-component response regulator, associated with ferric iron transporter, SPy1062 homolog Iron acquisition in Streptococcus 1 T2D_unique_201504_70_494_+ FIG00011622 4 2 5 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_201512_1_462_+ FIG00000015 5 4 6 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_201520_1_494_- FIG00000997 60 15 62 Protein RtcB RNA 3'-terminal phosphate cyclase 2 T2D_unique_201537_1_455_+ FIG00000065 65 11 66 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_201540_1_494_- FIG00003086 17 4 19 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_201548_183_494_- FIG00138182 7 2 9 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_201589_1_494_+ FIG00000480 14 4 15 5-nucleotidase SurE (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_201601_237_494_- FIG00000402 27 6 28 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_201603_1_494_- FIG00040817 5 2 7 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_201611_144_494_- FIG00009156 5 3 6 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_201614_1_494_+ FIG00075970 16 4 17 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_201647_1_494_- FIG00000080 76 14 77 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_201682_1_494_- FIG00000897 71 13 78 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_201683_1_494_+ FIG00000456 25 8 27 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_201685_134_494_+ FIG01954108 20 4 21 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Anaerobic respiratory reductases 3 T2D_unique_201723_1_372_- FIG00001695 75 11 79 D-serine dehydratase (EC 4.3.1.18) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_201729_1_494_+ FIG00002049 8 7 22 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_201740_1_459_- FIG00000081 114 17 114 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_201743_1_494_- FIG00001548 71 13 72 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_201749_311_494_- FIG00093180 48 7 48 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_201768_1_419_+ FIG00000025 4 3 5 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_201787_1_494_+ FIG00000156 3 2 5 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_201790_342_494_- FIG00001574 34 5 34 Alkylated DNA repair protein AlkB DNA repair, bacterial 3 T2D_unique_201792_1_494_- FIG00000114 120 17 120 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_201825_1_494_- FIG00010818 29 8 31 L-serine dehydratase, beta subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_201879_205_494_+ FIG00001616 25 6 27 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_201885_171_494_+ FIG00006463 7 3 8 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_201886_1_494_+ FIG00000242 128 20 128 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_201890_1_494_- FIG01260980 69 12 70 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_201907_1_365_+ FIG00000151 15 5 16 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_201929_1_494_+ FIG00008230 89 13 90 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_201964_1_424_- FIG00561498 12 3 14 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_201965_1_351_+ FIG00002344 4 2 6 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_201967_1_493_+ FIG00038456 16 7 22 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_201968_1_493_- FIG00000112 36 9 37 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_201981_1_493_+ FIG00000139 139 20 139 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_202001_1_131_+ FIG00006691 15 4 15 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_202001_150_493_+ FIG00002049 37 8 38 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_202015_1_493_- FIG00000865 68 10 69 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_202016_67_493_+ FIG00000812 27 6 28 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_202025_163_493_- FIG00000075 15 4 16 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_202088_1_345_+ FIG00133292 14 4 15 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_202116_1_493_- FIG00132586 26 8 27 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_202136_1_493_- FIG00000452 14 6 17 Chemotaxis protein methyltransferase CheR (EC 2.1.1.80) Bacterial Chemotaxis 9 T2D_unique_202151_1_493_- FIG00000866 146 20 146 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_202152_1_493_- FIG00041038 18 6 20 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_202167_1_493_- FIG00048014 14 6 15 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_202180_1_493_+ FIG00003251 24 8 27 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_202197_42_493_- FIG00077620 41 9 42 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_202202_1_371_+ FIG00002110 38 10 40 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_202217_1_493_+ FIG01260980 17 6 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_202219_7_493_- FIG00000025 17 8 36 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_202228_1_493_- FIG00108342 28 9 30 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_202229_1_493_- FIG00002034 13 4 14 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_202232_55_493_+ FIG01260980 95 14 98 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_202235_57_493_- FIG00000028 4 3 5 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_202240_134_493_+ FIG00093180 4 2 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_202249_1_461_+ FIG00000308 17 5 19 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_202251_86_493_- FIG00003394 15 5 17 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_202252_1_493_+ FIG00000081 130 19 130 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_202259_155_493_- FIG00001522 18 6 20 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_202266_1_493_+ FIG00000402 33 10 34 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_202279_1_262_- FIG00022300 9 3 10 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_202300_1_493_- FIG00008342 138 19 138 Anaerobic sulfite reductase subunit A Anaerobic respiratory reductases 3 T2D_unique_202327_8_388_- FIG00108342 21 5 23 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_202328_1_493_+ FIG00020613 48 10 49 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_202329_1_493_+ FIG00000245 115 19 115 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_202335_9_493_+ FIG00071708 6 3 8 CRISPR-associated protein Csm6 CRISPR-associated cluster 1 T2D_unique_202352_1_493_- FIG00000208 23 8 25 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_202356_1_493_+ FIG00003751 55 15 56 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_202360_45_493_+ FIG00001712 88 14 88 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_202404_332_493_- FIG00031969 5 3 7 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_202428_1_282_+ FIG00002148 8 4 9 Aspartate carbamoyltransferase regulatory chain (PyrI) De Novo Pyrimidine Synthesis 1 T2D_unique_202444_1_493_- FIG00011468 6 4 8 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_202453_195_493_+ FIG00000539 23 5 24 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_202461_1_493_+ FIG00000770 44 10 46 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_202481_1_380_- FIG00000205 90 15 90 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_202488_260_493_+ FIG00032749 13 3 14 Protein YicC CBSS-323097.3.peg.2594 1 T2D_unique_202492_184_493_+ FIG00000720 8 4 10 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_202500_85_493_- FIG00066425 3 2 5 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_202501_329_493_- FIG00000370 41 6 41 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_202512_342_493_+ FIG00000741 9 2 10 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_unique_202513_1_493_- FIG00132617 11 4 12 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_202531_310_493_+ FIG00018699 35 6 36 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_202555_1_493_- FIG00000877 133 19 134 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_202583_305_493_+ FIG00001522 17 3 18 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_202612_1_492_- FIG00000476 90 15 91 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_202625_190_492_- FIG00000308 26 4 27 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_202626_256_492_+ FIG00003788 17 4 19 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_202651_226_492_+ FIG00000112 55 10 55 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_202666_1_492_+ FIG00006649 134 19 135 Glutathione biosynthesis bifunctional protein gshF (EC 6.3.2.2)(EC 6.3.2.3) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_202680_1_168_+ FIG00002460 10 3 12 V-type ATP synthase subunit D (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_202686_1_492_- FIG00007586 94 17 95 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_202697_1_492_+ FIG00075702 58 16 64 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_202701_1_130_- FIG00041038 18 4 19 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_202701_196_492_- FIG00000775 4 2 5 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_202708_1_151_- FIG00133569 8 2 9 Segregation and condensation protein B Two cell division clusters relating to chromosome partitioning 1 T2D_unique_202714_251_492_- FIG00001882 28 5 28 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_202720_1_199_+ FIG00000184 36 7 36 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_202723_1_366_+ FIG00052300 6 3 8 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_202730_1_171_- FIG00020897 6 3 8 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_202737_1_492_- FIG00032753 124 19 125 Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine ECF class transporters 345678 T2D_unique_202746_1_492_- FIG00046929 77 13 78 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_202747_1_492_- FIG00002251 18 3 20 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_202755_253_492_+ FIG00018699 8 4 10 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_202758_61_492_- FIG00018396 11 5 17 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_202759_282_492_- FIG01310319 6 2 6 Exoenzymes regulatory protein AepA in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_202760_1_227_- FIG00000527 4 3 5 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_202771_1_143_- FIG00000261 10 2 13 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_202780_65_454_+ FIG00003460 25 5 26 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_202813_1_379_- FIG00052605 8 2 10 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_202824_234_428_+ FIG00046179 28 7 29 Lysine-arginine-ornithine-binding periplasmic protein precursor (TC 3.A.1.3.1) Arginine and Ornithine Degradation 1.34 T2D_unique_202828_1_248_- FIG00116638 7 4 8 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_202832_1_354_- FIG00035175 57 9 58 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_202870_1_492_- FIG00067681 137 19 137 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_202880_1_492_- FIG00134060 24 6 28 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_202885_1_384_+ FIG00017518 19 4 20 Alpha-L-arabinofuranosidase II precursor (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_202895_127_336_+ FIG00000578 8 3 9 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_202905_1_492_- FIG00000308 18 6 19 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_202928_1_473_+ FIG00001893 126 18 127 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_202941_1_492_+ FIG00001548 16 4 17 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_202969_39_492_+ FIG00011468 16 4 17 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_202977_1_492_- FIG00000038 122 19 122 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_202979_1_205_+ FIG00006764 4 2 5 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_202993_1_492_+ FIG00016566 22 7 23 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_202994_1_492_- FIG00000494 8 2 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_203018_153_492_- FIG00018865 18 6 19 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_203021_1_492_+ FIG00002620 115 19 115 Tyrosine-protein kinase transmembrane modulator EpsC Exopolysaccharide Biosynthesis 1.0 T2D_unique_203027_1_492_+ FIG00016685 15 4 17 Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter ECF class transporters 345678 T2D_unique_203041_179_492_+ FIG00019868 73 11 73 Maltose/maltodextrin ABC transporter, permease protein MalF Maltose and Maltodextrin Utilization 1.x T2D_unique_203045_1_492_+ FIG01304601 37 8 38 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_203050_1_262_+ FIG00001385 46 8 47 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_203054_1_492_- FIG00000147 38 10 39 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_203064_1_492_- FIG00000465 67 10 68 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_203074_1_492_- FIG00000116 7 2 8 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_203104_1_492_- FIG00009149 17 8 18 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_203106_1_164_- FIG00002914 3 2 4 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_203120_1_477_+ FIG00000139 83 13 85 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_203147_1_492_+ FIG00000268 96 17 97 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_203149_1_492_- FIG00140555 63 10 64 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_203153_355_492_- FIG00000234 8 3 8 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_203171_164_492_- FIG00034392 10 3 11 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_203194_1_382_- FIG00000402 8 3 9 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_203201_1_264_+ FIG00004014 5 3 9 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_203204_12_492_+ FIG00005243 36 5 40 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_203223_1_491_+ FIG00001915 73 13 75 Anaerobic glycerol-3-phosphate dehydrogenase subunit A (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_203225_1_491_+ FIG00023946 46 9 47 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_203227_1_491_- FIG00008736 7 3 10 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_203228_1_491_- FIG00003535 143 20 143 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_203245_1_491_- FIG00001269 55 12 56 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_203264_1_491_+ FIG01308794 23 5 24 Cyclic beta-1,2-glucan modification transmembrane protein Synthesis of osmoregulated periplasmic glucans 1.x T2D_unique_203294_188_491_+ FIG00080955 18 4 20 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_203319_80_491_- FIG00000139 54 11 55 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_203343_1_491_- FIG00002050 111 17 112 Urease alpha subunit (EC 3.5.1.5) Urease subunits 1.x T2D_unique_203350_1_491_+ FIG00000147 80 14 80 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_203354_78_491_- FIG00030688 82 12 83 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_203355_1_415_- FIG00000421 38 8 41 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_203360_24_491_- FIG00023004 6 4 8 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_203364_1_374_+ FIG00000494 6 3 8 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_203372_1_491_+ FIG00000552 32 7 34 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_203377_1_197_+ FIG00004014 10 3 12 RNA polymerase sporulation specific sigma factor SigE Transcription initiation, bacterial sigma factors 1 T2D_unique_203396_1_491_+ FIG00093180 47 11 48 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_203397_1_491_+ FIG00001932 38 7 40 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_203407_1_491_+ FIG00034392 21 6 22 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_203426_1_290_- FIG00000103 31 6 33 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_203453_1_491_- FIG00009910 16 5 18 Ribonuclease HI-related protein 3 Ribonuclease H 1.010 T2D_unique_203464_1_491_+ FIG00093180 73 14 74 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_203485_74_491_- FIG00016514 21 6 23 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_203513_1_491_+ FIG00000038 80 16 82 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_203558_1_483_- FIG00000474 64 13 66 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_203566_1_491_- FIG00451095 25 4 26 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_203585_112_491_+ FIG00719736 6 3 10 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_203617_1_491_+ FIG01304043 27 4 28 Competence/damage-inducible protein CinA CBSS-257314.1.peg.676 4.x T2D_unique_203620_1_254_+ FIG00135742 8 2 9 Ribonuclease HI-related protein Ribonuclease H 1.010 T2D_unique_203635_1_491_+ FIG00011659 44 11 45 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_203650_1_491_- FIG00134135 118 18 119 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_203655_257_491_- FIG00077620 9 4 10 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_203681_1_491_+ FIG00000116 33 9 34 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_203703_1_212_- FIG00093180 51 8 51 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_203737_1_491_+ FIG01176807 114 18 116 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_203739_1_224_- FIG00008591 12 3 12 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_203740_100_491_- FIG00010661 111 15 111 Alpha-L-Rha alpha-1,2-L-rhamnosyltransferase/alpha-L-Rha alpha-1,3-L- rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_203751_1_392_+ FIG00001054 66 12 67 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_203755_1_491_- FIG00561498 30 7 32 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_203757_1_424_+ FIG00001088 43 10 45 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_203770_1_491_+ FIG00000242 24 6 26 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_203799_1_491_- FIG00000147 64 10 65 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_203804_1_491_+ FIG00000156 37 8 38 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_203835_1_490_+ FIG00000578 137 20 137 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_203857_1_490_- FIG00041038 59 12 60 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_203885_1_490_- FIG00521220 7 4 8 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_203896_1_449_- FIG00006551 96 14 96 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_203901_1_348_- FIG00018536 45 9 47 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_203938_1_490_+ FIG00046902 6 3 7 Glutamine synthetase, clostridia type (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_204016_1_171_- FIG00051439 8 3 10 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_204047_127_490_+ FIG00000847 17 5 18 Allophanate hydrolase 2 subunit 1 (EC 3.5.1.54) EC699-706 1 T2D_unique_204113_1_490_- FIG00052605 12 5 20 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_204116_50_490_- FIG00001676 10 4 12 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_204120_1_490_- FIG00000252 19 4 21 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_204122_1_405_- FIG00042267 8 4 9 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_204158_1_490_+ FIG00013525 109 18 109 Stage III sporulation protein AH Sporulation Cluster III A 1.x T2D_unique_204175_1_490_- FIG00003174 30 8 32 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_204199_1_490_+ FIG00006235 84 14 85 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_unique_204201_1_490_+ FIG00000402 117 19 117 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_204206_75_490_- FIG01304818 26 8 27 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_204215_1_213_+ FIG00013638 5 2 7 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_204236_1_490_- FIG00002354 71 14 72 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_204237_1_490_+ FIG00001653 68 13 92 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_204239_1_490_+ FIG00000243 17 5 19 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_204248_202_490_+ FIG00000368 42 6 43 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_204251_174_490_+ FIG00003520 9 4 10 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_204253_1_490_- FIG00080955 33 10 35 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_204288_120_490_+ FIG00001712 4 3 5 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_204319_1_259_+ FIG00001088 21 5 21 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_204319_350_490_+ FIG00016663 4 2 5 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_204338_49_490_- FIG01709650 97 14 99 Amidases related to nicotinamidase NAD and NADP cofactor biosynthesis global E T2D_unique_204378_1_490_+ FIG00087623 11 3 13 Glycosyltransferase LafA, responsible for the formation of Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_204415_1_490_+ FIG00001819 86 15 87 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_204425_1_378_+ FIG00052605 21 6 24 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_204455_1_489_- FIG00136675 5 3 7 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_204463_1_462_+ FIG00000445 60 11 61 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_204480_1_489_- FIG01260980 136 19 136 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_204482_1_213_+ FIG01954097 17 5 18 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_204482_217_489_+ FIG00006691 16 4 17 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_204486_311_489_- FIG00002515 47 7 47 4-hydroxybenzoyl-CoA thioesterase family active site Ton and Tol transport systems 2 T2D_unique_204536_97_489_+ FIG00000659 31 7 32 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_204537_1_489_+ FIG00067681 83 14 84 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_204546_1_463_- FIG00007960 122 18 122 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_204583_256_489_- FIG00000085 62 8 62 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_204588_1_311_- FIG00002049 22 7 23 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_204588_326_489_- FIG00006691 12 2 12 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_204643_1_250_- FIG00133292 5 2 9 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_204661_1_290_- FIG00000280 18 7 20 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_204666_1_489_- FIG00004078 6 3 8 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_204668_176_466_+ FIG00006463 7 4 8 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_204669_1_476_- FIG00020185 97 16 97 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_204678_1_221_- FIG00000456 55 8 55 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_204686_195_489_+ FIG00000260 45 8 46 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_204716_1_478_+ FIG00000080 79 13 81 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_204719_156_489_+ FIG00002968 8 4 10 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_204737_1_489_+ FIG00001469 10 7 25 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_204739_1_279_- FIG00000047 20 5 21 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_204749_1_489_- FIG00004788 3 2 4 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_204755_1_489_+ FIG00000107 7 3 9 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_204759_43_489_- FIG00008708 4 3 6 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_204795_301_489_- FIG00000084 22 4 24 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_204806_1_489_- FIG00002050 62 14 63 Urease alpha subunit (EC 3.5.1.5) Urease subunits 1.x T2D_unique_204809_1_149_- FIG00000047 32 5 32 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_204834_1_489_- FIG00080231 19 5 21 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_204844_1_489_+ FIG00001088 116 18 116 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_204852_210_489_- FIG00132787 45 8 46 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_204863_1_258_+ FIG00000116 5 2 6 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_204878_1_489_- FIG01260980 21 7 23 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_204918_346_489_+ FIG00001530 35 5 35 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_204922_1_489_- FIG01007502 8 3 10 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_204923_1_489_+ FIG00000202 14 4 16 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_204937_1_489_+ FIG00038343 6 3 8 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_204943_321_489_+ FIG00001198 5 2 6 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_204945_1_489_- FIG00001882 9 6 13 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_204950_1_375_- FIG00000235 91 14 91 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_204973_136_489_- FIG01956497 46 8 56 Multiple sugar ABC transporter, membrane-spanning permease protein MsmG Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_204981_212_489_+ FIG00000203 64 10 64 SSU ribosomal protein S12p (S23e) Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_204986_1_489_+ FIG00001642 23 7 26 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_204992_1_489_+ FIG00011468 30 8 32 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_204996_339_489_+ FIG00086697 4 2 5 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_205001_1_162_+ FIG00000401 7 2 8 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_205001_164_489_+ FIG00002803 11 7 12 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_205006_1_340_+ FIG00038920 29 6 30 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_205033_1_489_+ FIG00001198 5 3 7 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_205036_1_489_- FIG00139192 22 9 23 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_205040_177_489_- FIG00000296 21 5 23 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_unique_205052_1_489_+ FIG00000455 134 19 134 Malate dehydrogenase (EC 1.1.1.37) Serine-glyoxylate cycle 1 T2D_unique_205059_1_488_- FIG00011468 14 5 17 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_205086_278_488_- FIG00000116 13 3 15 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_205116_198_488_- FIG00093180 8 2 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_205119_1_488_+ FIG00003788 10 5 12 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_205135_1_488_+ FIG00001548 11 5 12 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_205157_46_488_+ FIG00000695 16 4 17 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_205177_1_256_+ FIG00058998 22 7 23 Vancomycin response regulator VanR Resistance to Vancomycin X T2D_unique_205193_1_358_+ FIG00000065 9 3 10 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_205226_1_486_+ FIG00521220 4 3 6 O-antigen export system permease protein RfbD Rhamnose containing glycans 4.1 T2D_unique_205272_1_346_- FIG00001618 3 2 5 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_205292_1_488_- FIG00001189 90 15 91 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_205299_1_410_+ FIG00052730 8 3 10 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_205301_1_488_- FIG00059211 15 7 17 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_205303_1_488_+ FIG00059211 5 3 7 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_205336_39_488_+ FIG00000355 22 7 23 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_205342_1_478_+ FIG00000866 7 2 8 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_205347_280_488_+ FIG00001385 33 7 33 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_205366_67_488_- FIG00000351 19 5 20 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_205385_208_488_- FIG00013609 69 10 70 DNA-entry nuclease (Competence-specific nuclease) (EC 3.1.30.-) Gram Positive Competence 3100 T2D_unique_205392_1_488_+ FIG00026918 120 19 120 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_205413_1_488_- FIG00000584 78 12 79 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_205420_1_488_- FIG00018328 5 2 7 Glycosyl transferase, group 1 CBSS-258594.1.peg.3339 1 T2D_unique_205473_290_488_+ FIG00001039 56 8 56 Ribonucleotide reduction protein NrdI Ribonucleotide reduction 1 T2D_unique_205485_1_488_+ FIG00000128 54 10 55 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_205504_1_488_- FIG00000681 108 17 109 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_unique_205511_1_488_- FIG00028203 72 14 72 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_205512_267_488_- FIG00004655 7 4 8 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_205518_1_176_- FIG00001235 17 3 18 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (EC 3.1.1.-) Capsular heptose biosynthesis 1 T2D_unique_205551_1_488_+ FIG00008941 61 11 62 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_205568_1_488_- FIG00051957 5 2 6 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_205570_1_488_- FIG00000157 33 9 35 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_205571_1_266_- FIG00006463 3 3 5 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_205652_1_488_- FIG00132617 15 6 16 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_205655_267_488_+ FIG00006032 6 2 7 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_205666_150_488_+ FIG00005283 8 4 10 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_205681_1_488_+ FIG00000494 84 12 85 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_205686_1_488_- FIG00133143 55 12 56 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) Cysteine Biosynthesis 2.17 T2D_unique_205713_1_487_- FIG01956504 7 3 9 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_205716_1_487_- FIG00143531 7 4 14 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_unique_205729_1_487_- FIG00000494 3 4 5 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_205731_48_487_- FIG00000402 94 15 95 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_205790_1_357_+ FIG00022300 31 8 32 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_205794_1_278_+ FIG00000532 15 5 17 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_205798_1_487_+ FIG00001469 48 10 49 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_205800_1_487_- FIG00048014 58 12 81 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_205806_286_487_- FIG00117785 13 5 14 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_unique_205815_1_487_+ FIG00001712 123 18 123 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_205825_1_487_- FIG00002470 17 5 19 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_205851_1_487_+ FIG00020897 111 18 112 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_205855_20_487_- FIG00000011 128 19 128 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_205884_1_487_+ FIG00001548 45 9 47 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_205902_11_487_+ FIG00001504 28 8 29 Serine--glyoxylate aminotransferase (EC 2.6.1.45) Serine-glyoxylate cycle 1 T2D_unique_205903_1_422_- FIG00000479 12 2 13 Zinc uptake regulation protein ZUR Zinc regulated enzymes 1 T2D_unique_205914_1_487_- FIG00132617 22 7 23 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_205924_1_487_- FIG00000011 8 3 9 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_205949_1_487_- FIG00046929 21 6 23 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_206008_63_487_+ FIG00010414 121 17 121 ComF operon protein A, DNA transporter ATPase Gram Positive Competence 3100 T2D_unique_206018_1_487_+ FIG00024999 17 6 19 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Alkanesulfonate assimilation 9.? T2D_unique_206046_1_352_+ FIG00138468 4 3 6 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_206061_1_276_- FIG00013638 53 10 53 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_206117_1_487_+ FIG00046929 3 4 7 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_206119_1_487_- FIG00003435 121 18 122 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_206136_1_430_- FIG00016768 118 17 118 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_206176_191_487_- FIG00001499 79 12 79 GTP-binding protein YqeH, required for biogenesis of 30S ribosome subunit Universal GTPases 2 T2D_unique_206179_1_251_- FIG00000402 33 7 34 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_206181_52_487_+ FIG00023946 86 16 87 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_206199_32_187_- FIG00719736 30 5 30 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_206201_1_207_+ FIG00000205 21 6 22 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_206225_1_426_+ FIG00003460 120 17 120 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_206249_1_347_- FIG00012746 11 3 12 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_206254_301_487_+ FIG00134889 31 6 32 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_206264_1_487_- FIG00138523 13 6 20 Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-) Acetoin, butanediol metabolism 5 T2D_unique_206279_1_487_- FIG00451095 6 3 8 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_206314_1_281_+ FIG00044622 35 6 36 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_206351_122_487_- FIG00006092 29 7 31 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_206353_1_391_+ FIG00047056 86 14 86 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_206372_1_486_+ FIG01007502 6 3 8 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_206414_1_486_- FIG00000463 13 5 16 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_206417_1_365_- FIG00019251 28 6 31 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_206437_1_486_- FIG00001354 6 2 8 Hydroxylamine reductase (EC 1.7.-.-) Nitrosative stress 4 T2D_unique_206467_1_486_- FIG00011114 40 9 41 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_206472_1_486_+ FIG00029916 64 11 78 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_206479_1_486_+ FIG01304229 15 4 16 MSM (multiple sugar metabolism) operon regulatory protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_206502_1_486_+ FIG00001635 15 3 17 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_206509_97_486_- FIG00000269 105 15 105 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_206520_189_486_+ FIG00001210 27 6 29 [NiFe] hydrogenase nickel incorporation-associated protein HypB NiFe hydrogenase maturation 1 T2D_unique_206526_26_486_- FIG00015338 27 8 28 D-beta-hydroxybutyrate permease Polyhydroxybutyrate metabolism 5.6 T2D_unique_206528_1_486_- FIG00000088 5 2 8 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_206537_71_340_+ FIG00000385 7 2 8 Cell division protein FtsA Cell Division Cluster 1.x T2D_unique_206541_186_486_+ FIG00080231 8 2 11 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_206546_1_486_+ FIG00134830 61 11 63 Lysine 2,3-aminomutase (EC 5.4.3.2) Lysine degradation 1.0 T2D_unique_206549_60_401_- FIG00000219 75 12 76 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_206561_271_486_- FIG00000897 10 3 12 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_206606_1_211_+ FIG00000159 44 7 44 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_206643_1_486_+ FIG00561498 23 7 26 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_206649_222_486_+ FIG00007658 3 3 4 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_206659_27_486_- FIG01007502 10 7 12 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_206668_1_444_- FIG00002489 3 2 4 Spore germination protein GerKA Spore germination 1 T2D_unique_206689_1_486_+ FIG00001635 18 6 20 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_206701_1_349_- FIG00000151 97 14 97 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_206710_1_486_- FIG00010738 17 6 19 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_206719_1_486_+ FIG00059211 20 5 21 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_206732_1_486_- FIG00011423 125 19 125 Ferredoxin reductase Anaerobic respiratory reductases 3 T2D_unique_206745_1_486_+ FIG00000356 46 10 48 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_206746_1_440_+ FIG00000411 9 4 10 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_206747_1_178_- FIG00003596 6 2 7 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_206747_185_486_- FIG01031896 28 4 30 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_206748_1_486_- FIG00000352 91 16 92 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_206817_1_212_+ FIG00093180 58 8 58 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_206824_1_223_- FIG00011537 11 3 12 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_206833_308_486_+ FIG00000157 15 3 16 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_206842_1_486_+ FIG00006734 11 5 13 4-amino-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) acetyltrasferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_206852_223_486_- FIG00010844 29 5 30 Flavodoxin Flavodoxin 1 T2D_unique_206876_1_486_- FIG00000114 34 6 35 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_206901_1_356_- FIG00002716 6 2 7 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_206912_41_486_+ FIG00001105 26 10 27 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_unique_206917_1_486_+ FIG00064110 48 10 49 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_206919_1_486_- FIG00000320 8 4 9 Ubiquinone biosynthesis monooxygenase UbiB Ubiquinone Biosynthesis 2.x T2D_unique_206933_137_486_- FIG00000382 94 14 94 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_206940_1_486_- FIG00017431 112 18 112 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_unique_206974_1_368_- FIG00002252 14 4 17 Galactose/methyl galactoside ABC transport system, D-galactose-binding periplasmic protein MglB (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_206991_85_485_+ FIG00000621 11 6 13 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_206994_1_485_+ FIG00135469 16 4 17 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_207000_94_485_- FIG00026006 9 2 10 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_207007_1_239_- FIG00000184 23 4 24 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_207033_1_366_+ FIG00001179 22 6 24 Macrolide-specific efflux protein MacA Multidrug Resistance Efflux Pumps 1.12 T2D_unique_207049_1_485_- FIG00018699 72 14 98 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_207054_12_485_- FIG00000356 36 9 38 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_207055_1_421_- FIG00000025 5 4 6 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_207067_1_473_- FIG00002385 10 5 13 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_207082_65_485_- FIG00021644 21 5 24 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_207087_1_485_+ FIG00001546 51 11 52 Poly(glycerophosphate chain) D-alanine transfer protein DltD D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_207091_331_485_+ FIG00000659 35 6 35 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_207094_1_426_+ FIG00008907 118 17 119 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_207117_1_231_+ FIG00000370 18 4 19 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_207133_264_485_- FIG00001579 51 7 51 D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13) D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_207143_1_485_- FIG00000385 102 15 103 Cell division protein FtsA Cell Division Cluster 1.x T2D_unique_207149_110_485_- FIG00000717 5 4 7 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_207153_1_267_- FIG00018328 13 3 15 Glycosyl transferase, group 1 CBSS-258594.1.peg.3339 1 T2D_unique_207161_1_485_+ FIG00005547 6 4 8 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_unique_207167_1_485_+ FIG00022300 11 5 12 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_207175_67_485_+ FIG00060517 28 7 30 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_207213_1_485_+ FIG00002344 6 4 8 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_207220_300_485_+ FIG00000256 10 3 11 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_207252_243_485_+ FIG00005587 22 4 23 Transcriptional regulator of rhamnose utilization, AraC family L-rhamnose utilization 1 T2D_unique_207272_1_485_+ FIG00001583 9 3 10 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_207314_1_485_+ FIG00008294 136 19 136 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_207365_1_485_- FIG00132617 125 18 125 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_207368_1_485_+ FIG00018457 94 16 94 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_207370_1_485_- FIG00181043 135 19 135 Pullulanase (EC 3.2.1.41) Maltose and Maltodextrin Utilization 1.x T2D_unique_207373_1_485_+ FIG00028461 4 4 7 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_207400_1_485_- FIG00000126 79 16 90 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_207412_1_485_+ FIG00001029 115 17 115 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_207449_335_485_- FIG00017454 11 3 12 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_207452_1_485_- FIG00002689 116 19 117 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_207468_1_485_+ FIG00059211 37 10 39 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_207494_1_485_- FIG00041038 6 3 7 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_207517_1_485_+ FIG00046929 125 18 126 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_207528_1_355_- FIG00018457 7 3 8 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_207531_1_485_- FIG00001518 8 3 10 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_207575_1_341_- FIG00001474 70 12 71 Ribonuclease HIII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_207586_1_386_+ FIG00000449 34 7 36 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_207602_1_485_- FIG00000402 26 7 28 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_207628_1_485_- FIG00005992 127 19 127 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_207635_1_485_- FIG00001280 17 6 19 Selenocysteine-specific translation elongation factor Selenocysteine metabolism 1.1 T2D_unique_207652_39_485_- FIG00016110 91 14 92 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_207655_1_208_+ FIG00005728 10 3 11 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_207667_1_484_- FIG00000356 63 14 64 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_207686_1_314_+ FIG00016286 83 12 83 Ribosyl nicotinamide transporter, PnuC-like Cobalt-zinc-cadmium resistance 1.26 T2D_unique_207697_1_334_+ FIG00000273 17 5 18 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_unique_207703_1_412_+ FIG00126843 4 2 5 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_207728_212_484_- FIG00000301 25 6 26 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_207745_1_484_+ FIG00003174 21 7 22 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_207777_1_484_+ FIG00000260 20 7 22 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_207816_145_484_+ FIG01260980 3 2 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_207819_105_299_- FIG00084255 7 2 8 Stage III sporulation protein AC Sporulation Cluster III A 1.x T2D_unique_207827_1_484_+ FIG00000445 97 15 98 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_207833_1_175_+ FIG00000155 19 4 20 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_207842_1_484_+ FIG00001469 119 18 119 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_207846_1_484_+ FIG00000317 34 8 35 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_207938_1_484_- FIG00067681 13 6 15 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_207949_1_386_+ FIG00041038 8 3 9 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_207970_212_484_- FIG00000245 9 4 11 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_207978_1_484_- FIG00008941 118 18 119 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_207987_64_484_- FIG00064110 56 11 57 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_208027_1_481_+ FIG00001175 123 19 123 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_208037_45_365_+ FIG00005243 29 6 31 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_208052_1_424_+ FIG00133219 58 10 61 Thiamin biosynthesis lipoprotein ApbE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_208060_38_484_- FIG00010760 94 16 94 Sensor histidine kinase colocalized with HrtAB transporter Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_208070_1_270_+ FIG00000437 9 3 10 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_208075_225_484_+ FIG00000522 63 9 63 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_208086_104_484_- FIG00229257 86 13 91 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_208110_77_484_- FIG00010078 3 2 4 Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine ECF class transporters 345678 T2D_unique_208135_263_484_- FIG00000435 9 3 16 Exodeoxyribonuclease VII small subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_208140_1_374_- FIG00000163 20 3 21 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_208186_1_484_- FIG00000146 114 18 116 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_208189_1_484_+ FIG00071623 125 18 125 Naphthoate synthase (EC 4.1.3.36) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_208194_144_484_+ FIG00001505 54 9 56 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_208199_31_258_- FIG00001980 14 4 15 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_208202_234_484_- FIG01010650 17 4 18 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_208210_50_454_- FIG00001221 93 14 93 Alkanesulfonates-binding protein Alkanesulfonates Utilization 20 T2D_unique_208231_1_484_+ FIG00000111 56 11 57 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_208254_1_484_- FIG00000268 41 8 42 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_208297_1_334_+ FIG00045144 12 4 13 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_208310_1_484_+ FIG00000494 16 5 17 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_208342_1_483_+ FIG00041038 50 10 51 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_208354_166_483_+ FIG00000234 68 12 68 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_208361_1_483_+ FIG00075702 49 10 50 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_208384_106_483_- FIG00000151 23 6 24 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_208396_1_483_+ FIG00000320 51 12 52 Ubiquinone biosynthesis monooxygenase UbiB Ubiquinone Biosynthesis 2.x T2D_unique_208422_1_263_+ FIG00687285 24 4 25 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_unique_208445_1_483_+ FIG00021289 131 19 131 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_208463_1_401_+ FIG00000372 14 4 16 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_208478_66_483_+ FIG00002289 15 3 19 Soluble lytic murein transglycosylase precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_208480_1_483_- FIG00005237 6 2 7 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_208497_1_483_+ FIG00052730 56 10 57 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_208502_1_357_+ FIG00030688 53 10 54 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_208519_69_483_- FIG00000098 16 7 18 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_208539_1_303_- FIG00000141 15 5 16 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_208542_1_483_- FIG01955782 21 5 22 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_208618_1_483_- FIG00000287 51 10 52 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_208640_1_483_+ FIG00000134 48 11 49 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_208659_1_483_- FIG00000111 58 12 59 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_208663_1_483_+ FIG00021289 85 15 85 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_208678_1_483_+ FIG00000343 37 7 39 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_208682_1_483_- FIG00085182 81 15 82 NAD-dependent formate dehydrogenase alpha subunit Formate hydrogenase 3.1?? T2D_unique_208689_1_307_+ FIG00000312 39 9 40 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_208697_1_483_- FIG00067681 46 10 47 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_208704_1_409_+ FIG00091940 27 8 28 Histidine ammonia-lyase (EC 4.3.1.3) Histidine Degradation 1.100 T2D_unique_208727_1_250_+ FIG00001094 49 8 50 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_208727_255_483_+ FIG00017454 37 6 37 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_208739_43_483_- FIG00012067 17 6 19 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_208745_1_483_+ FIG00049915 41 10 43 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_208754_1_291_- FIG00001522 60 10 61 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_208754_355_483_- FIG00005022 31 5 31 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_208781_1_416_+ FIG01260980 14 6 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_208782_1_483_- FIG00000011 9 4 12 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_208801_1_483_+ FIG00000147 11 4 13 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_208810_1_129_+ FIG00000341 19 4 20 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_208817_1_483_- FIG00028203 71 15 73 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_208841_143_483_- FIG00133034 3 2 5 Excinuclease ABC subunit A paralog of unknown function DNA repair, UvrABC system 1 T2D_unique_208848_1_483_+ FIG00042267 40 9 41 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_208873_1_483_+ FIG00073301 9 2 10 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_208881_1_483_- FIG00000391 77 14 79 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_208936_1_483_+ FIG01304734 30 9 33 MreB-like protein (Mbl protein) Sporulation-related Hypotheticals 2.x T2D_unique_208943_1_483_+ FIG00066425 73 15 74 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_208983_1_482_+ FIG00002944 4 3 8 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_unique_208997_1_482_- FIG00000522 48 10 51 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_209032_1_482_+ FIG00001635 31 8 32 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_209046_180_482_- FIG00010771 63 10 63 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_209085_1_482_- FIG01260980 138 19 138 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_209097_1_482_- FIG00000279 34 7 36 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_209161_1_482_+ FIG00018865 79 14 79 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_209163_41_482_- FIG00503691 9 3 10 Cadmium-transporting ATPase (EC 3.6.3.3) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_209185_1_477_+ FIG00049915 92 16 93 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_209191_1_482_- FIG00028461 122 17 123 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_209203_1_482_- FIG00133227 114 19 115 N-acetylneuraminate lyase (EC 4.1.3.3) Sialic Acid Metabolism 1.x T2D_unique_209248_1_482_- FIG00028461 38 9 40 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_209291_1_482_+ FIG00043259 3 2 5 Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_209293_1_482_- FIG00000032 37 8 38 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_209304_1_482_+ FIG00000103 113 19 113 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_209323_86_482_- FIG00137767 28 7 30 Legionaminic acid biosynthesis protein PtmG Legionaminic Acid Biosynthesis 1.x T2D_unique_209345_1_190_+ FIG00000317 20 4 23 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_209347_1_306_+ FIG00000624 29 7 30 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_209358_1_237_+ FIG00002849 6 3 7 Putative predicted metal-dependent hydrolase Restriction-Modification System 3.x T2D_unique_209397_1_482_+ FIG00000268 55 10 57 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_209412_1_337_- FIG00003175 15 4 16 Pyruvate:ferredoxin oxidoreductase, beta subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_209419_1_482_+ FIG00005727 15 5 16 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_209424_1_482_+ FIG00000304 38 10 42 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_209481_1_482_- FIG00028461 17 8 18 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_209482_1_174_+ FIG00000301 29 4 30 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_209482_312_482_+ FIG00000333 47 6 47 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_209527_1_482_- FIG00002265 3 4 5 Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE Maltose and Maltodextrin Utilization 1.x T2D_unique_209536_282_482_- FIG00009229 39 7 39 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_209545_110_482_- FIG00000168 11 2 13 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_209548_284_482_+ FIG01260980 4 2 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_209565_104_482_- FIG00006889 51 8 53 L-rhamnose isomerase (EC 5.3.1.14) L-rhamnose utilization 1 T2D_unique_209587_258_482_- FIG00000269 15 4 17 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_209588_1_437_+ FIG00135025 121 17 121 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_209606_1_481_+ FIG00340292 11 3 12 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_209645_1_481_- FIG00000962 4 3 6 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_209646_1_435_- FIG00007328 6 3 9 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_209669_1_481_- FIG00080955 41 10 43 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_209676_1_481_+ FIG00001264 119 17 120 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_209683_1_481_- FIG01260980 15 6 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_209698_1_481_+ FIG00001269 43 11 45 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_209719_1_481_- FIG00049433 11 5 13 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_209726_80_481_+ FIG00000812 14 5 20 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_209728_280_481_- FIG00015476 18 3 19 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_unique_209768_292_481_+ FIG00014000 10 3 12 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_209774_1_481_- FIG00029758 123 19 123 N-carbamoyl-L-amino acid hydrolase (EC 3.5.1.87) Hydantoin metabolism 4 T2D_unique_209788_1_481_- FIG00026918 16 5 18 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_209792_1_481_- FIG00001882 122 19 124 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_209802_1_481_- FIG00138004 26 7 27 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_209808_1_481_- FIG00000990 37 9 38 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_209834_147_481_- FIG00000163 89 13 89 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_209873_1_481_- FIG00046929 120 19 120 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_209890_1_481_+ FIG01304275 9 4 11 Ferrichrome transport ATP-binding protein FhuC (TC 3.A.1.14.3) Hemin transport system 1 T2D_unique_209911_1_481_+ FIG00002049 20 9 21 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_209928_1_481_- FIG00023943 32 8 33 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_209929_112_481_- FIG00021644 25 5 27 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_209941_168_481_+ FIG00007339 82 12 82 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_209942_1_481_- FIG00000107 50 10 52 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_209960_1_481_- FIG00000084 44 8 46 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_209995_220_481_+ FIG01271998 59 9 59 Possible hypoxanthine oxidase XdhD (EC 1.-.-.-) Purine conversions 4.1118100 T2D_unique_210008_1_469_- FIG00139238 31 8 32 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_210010_1_481_- FIG00000309 26 9 28 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_210014_1_481_- FIG00000582 6 5 8 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_210021_66_481_- FIG00058830 120 17 120 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_210029_1_481_- FIG00000086 78 14 79 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_210032_1_481_+ FIG00074225 136 19 136 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_210034_195_481_+ FIG00041038 9 3 10 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_210038_140_481_+ FIG00003845 4 2 5 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_210065_28_324_- FIG00000494 28 6 29 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_210085_1_481_- FIG00058830 89 14 97 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_210087_1_233_- FIG00003435 23 5 25 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_210091_269_481_- FIG00028694 15 4 16 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_210106_353_481_- FIG00000557 7 3 8 FIG000557: hypothetical protein co-occurring with RecR DNA processing cluster 1.1 T2D_unique_210112_305_481_- FIG00000139 6 3 7 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_210124_1_481_+ FIG00007957 42 10 44 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_210151_1_196_- FIG00000377 23 4 24 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_210157_54_481_+ FIG00000376 73 12 73 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_210160_1_481_+ FIG00000402 25 7 26 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_210173_1_481_- FIG00000329 100 17 101 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_210201_42_481_- FIG00000555 47 9 48 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_210206_1_481_+ FIG00000439 89 15 89 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_210219_231_481_+ FIG00002541 8 2 9 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_210224_1_195_+ FIG00000147 11 5 12 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_210227_1_321_- FIG00000584 15 6 16 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_210237_1_481_+ FIG00002344 28 9 30 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_210238_1_190_- FIG00000660 47 7 48 Cystathionine gamma-synthase (EC 2.5.1.48) Methionine Biosynthesis 8 T2D_unique_210248_1_480_+ FIG00008230 81 13 83 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_210252_1_222_- FIG00000303 22 5 23 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_210252_227_480_+ FIG00004764 8 4 11 Ammonium transporter Ammonia assimilation 1 T2D_unique_210270_1_480_- FIG00001088 31 8 33 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_210302_151_480_- FIG00002914 64 11 65 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_210312_1_480_+ FIG00001469 9 5 10 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_210332_1_480_- FIG00019251 11 4 14 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_210365_113_480_- FIG00000028 95 14 95 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_210372_275_480_+ FIG00006463 15 3 17 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_210378_1_480_- FIG00048014 26 9 28 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_210385_1_480_- FIG00058830 116 17 118 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_210410_1_396_+ FIG00000343 54 10 57 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_210433_1_480_- FIG00000157 127 18 129 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_210439_122_480_+ FIG00000476 7 3 8 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_210467_1_480_+ FIG00000139 31 7 32 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_210468_1_341_- FIG00000402 91 14 91 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_210498_1_454_+ FIG01304043 5 4 8 Competence/damage-inducible protein CinA CBSS-257314.1.peg.676 4.x T2D_unique_210521_1_480_- FIG00046929 19 5 21 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_210588_1_480_+ FIG00035175 18 7 20 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_210633_1_326_+ FIG00001106 70 10 72 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_210653_277_480_+ FIG00000704 46 7 46 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_210664_1_444_+ FIG00004170 118 17 118 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_210666_1_480_- FIG00007059 23 5 26 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_210670_1_480_- FIG00002385 130 19 130 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_210688_1_417_+ FIG00000411 99 16 99 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_210722_298_480_+ FIG00000422 7 3 8 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_210742_1_480_- FIG00010194 97 16 98 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_210761_1_222_+ FIG00000149 18 4 20 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_210771_1_480_+ FIG00024930 95 16 96 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_210814_1_480_- FIG00028694 58 15 59 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_210820_1_480_- FIG00000055 35 8 36 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_210821_1_417_- FIG00000450 52 8 53 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_210827_127_480_- FIG00006151 77 12 77 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_210840_1_480_+ FIG00001548 58 11 59 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_210884_1_320_- FIG00000184 83 12 83 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_210893_334_480_- FIG00003751 15 2 15 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_210925_1_479_+ FIG01292786 20 6 22 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_210933_326_479_+ FIG00000402 12 3 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_210946_1_479_+ FIG01318398 112 17 116 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_210960_1_178_- FIG00002723 33 7 34 Ribonuclease E inhibitor RraB RNA processing and degradation, bacterial 1 T2D_unique_210963_1_479_- FIG00002300 9 2 10 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_210973_1_160_- FIG00019251 6 2 7 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_210975_1_479_- FIG01260980 42 9 44 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_211011_1_479_+ FIG00001548 3 2 5 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_211016_173_479_- FIG00028694 15 5 17 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_211046_1_479_+ FIG00031759 4 2 9 Periplasmic beta-glucosidase (EC 3.2.1.21) Beta-Glucoside Metabolism 2.bc T2D_unique_211116_1_479_- FIG00007941 11 5 12 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_211136_1_343_+ FIG00000522 79 13 79 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_211137_1_479_+ FIG00001882 25 8 26 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_211149_1_366_+ FIG00000437 26 7 27 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_211169_1_479_+ FIG00018536 5 2 6 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_211180_1_158_- FIG00026137 31 6 31 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_211228_99_479_+ FIG01307086 30 6 33 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_211283_1_199_+ FIG00017190 18 5 19 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_211314_1_479_- FIG00087875 37 7 38 Multidrug-efflux transporter, major facilitator superfamily (MFS) (TC 2.A.1) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_211320_1_264_- FIG00000304 13 6 14 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_211324_1_479_- FIG00018369 19 4 24 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_211380_1_479_- FIG00000168 15 7 17 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_211389_1_479_- FIG00001469 6 3 7 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_211397_301_479_+ FIG00000555 11 2 12 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_211398_1_479_- FIG00002163 40 8 41 Rhamnulose-1-phosphate aldolase (EC 4.1.2.19) L-rhamnose utilization 1 T2D_unique_211409_1_479_+ FIG00049915 64 13 65 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_211429_1_479_- FIG00093180 4 2 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_211446_1_479_+ FIG00004027 16 5 18 CoB--CoM heterodisulfide reductase subunit B (EC 1.8.98.1) Anaerobic respiratory reductases 3 T2D_unique_211454_1_175_- FIG00001269 18 4 19 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_211454_327_479_- FIG00038814 9 2 10 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_211476_1_443_+ FIG00000287 20 5 22 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_211501_1_479_- FIG00002385 11 4 13 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_211503_1_272_- FIG00010844 38 8 39 Flavodoxin Flavodoxin 1 T2D_unique_211507_1_479_- FIG00003433 123 19 123 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_211531_1_161_- FIG00001630 23 4 23 Alpha-aspartyl dipeptidase Peptidase E (EC 3.4.13.21) EC 3.4.13.- Dipeptidases 1 T2D_unique_211565_27_479_- FIG00000364 32 6 33 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) Coenzyme A Biosynthesis A.191 T2D_unique_211570_1_479_+ FIG01260980 139 19 139 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_211584_250_479_- FIG00019251 35 6 36 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_211589_172_479_- FIG00011114 13 3 15 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_211609_1_416_- FIG00001518 35 6 36 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_211614_98_478_- FIG01031896 103 15 103 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_211619_1_410_+ FIG00000283 7 4 9 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_211622_156_478_+ FIG00001237 40 8 42 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_211625_169_478_+ FIG01307086 60 10 60 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_211639_1_478_+ FIG00031723 10 4 13 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_unique_211643_1_296_- FIG00000131 16 4 17 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_211643_320_478_- FIG00075702 20 4 20 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_211656_97_478_+ FIG00009775 19 6 21 Glycosyl transferase, group 1 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_211662_1_209_+ FIG00000139 15 3 17 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_211677_1_478_+ FIG00060517 34 7 35 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_211730_1_478_+ FIG01318398 71 11 72 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_211760_1_478_+ FIG01260980 12 5 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_211803_127_478_+ FIG00001052 23 5 24 ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) LOS core oligosaccharide biosynthesis 1.x T2D_unique_211816_1_478_- FIG00019251 58 12 59 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_211828_1_349_+ FIG00000015 40 9 42 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_211837_1_478_+ FIG00001579 3 2 5 D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13) D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_211841_59_256_- FIG00000435 4 2 6 Exodeoxyribonuclease VII small subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_211841_295_478_- FIG00000323 5 3 6 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_211842_1_478_+ FIG00000422 29 8 30 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_211871_2_478_- FIG00007031 135 19 135 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase (EC 2.5.1.-) Chorismate Synthesis 1 T2D_unique_211898_1_478_+ FIG00132717 22 10 25 ATP-dependent protease La (EC 3.4.21.53) Type II Proteasome bacterial 1 T2D_unique_211903_1_478_+ FIG00035175 22 7 24 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_211905_1_291_- FIG00066425 21 4 23 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_211908_1_478_- FIG00000055 70 14 72 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_211928_1_164_- FIG00000711 39 6 39 Phosphoenolpyruvate carboxylase (EC 4.1.1.31) Serine-glyoxylate cycle 1 T2D_unique_211931_281_478_- FIG00002395 51 8 51 Cysteinyl-tRNA synthetase related protein CBSS-261594.1.peg.788 1 T2D_unique_211952_1_478_- FIG00561498 39 10 41 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_211970_1_360_- FIG00011423 12 3 14 Ferredoxin reductase Anaerobic respiratory reductases 3 T2D_unique_211976_1_478_+ FIG00066643 9 5 12 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_211992_1_478_+ FIG00003984 110 18 110 D-serine/D-alanine/glycine transporter Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_211994_1_247_+ FIG00001653 18 5 19 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_212017_1_478_+ FIG01260980 32 10 34 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_212020_1_138_- FIG00020613 22 5 22 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_212059_1_478_- FIG00002470 12 2 14 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_212077_1_221_- FIG00000038 19 4 20 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_212083_1_478_+ FIG00006542 4 5 6 FIG006542: Phosphoesterase CBSS-257314.1.peg.676 4.x T2D_unique_212086_1_383_+ FIG00000412 92 14 92 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_212098_1_478_- FIG00075970 10 4 12 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_212104_1_365_+ FIG00000494 16 4 17 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_212150_156_478_+ FIG00079822 20 6 22 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_212151_1_300_+ FIG00006463 3 2 4 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_212166_1_478_+ FIG00003555 10 4 11 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_212176_1_478_- FIG00005698 16 4 17 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_212191_1_478_- FIG00000111 92 14 93 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_212210_1_478_- FIG00009894 106 16 106 Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine ECF class transporters 345678 T2D_unique_212256_1_478_- FIG00000080 22 8 23 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_212281_1_477_+ FIG01280345 22 5 24 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_212295_1_477_+ FIG00561498 15 5 17 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_212300_1_477_+ FIG00028476 12 4 14 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_212320_1_477_- FIG00000210 32 10 34 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_212323_105_477_+ FIG00000040 54 9 55 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_212356_223_477_- FIG00051313 54 9 54 ATPase component NikO of energizing module of nickel ECF transporter ECF class transporters 345678 T2D_unique_212368_157_477_- FIG00000011 13 3 14 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_212402_210_477_- FIG00007658 19 6 20 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_212407_227_477_- FIG00018865 17 6 18 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_212451_76_477_+ FIG00007960 7 4 11 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_212474_1_477_- FIG00000243 20 6 21 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_212488_1_460_- FIG00048268 67 13 69 Membrane protein associated with methylmalonyl-CoA decarboxylase Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_212491_1_477_+ FIG00001548 38 8 40 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_212503_1_477_+ FIG00000555 22 6 27 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_212515_1_477_+ FIG00016566 5 3 7 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_212516_164_477_- FIG00037500 4 2 6 Phage minor capsid protein Phage head and packaging 1 T2D_unique_212518_1_477_- FIG00060517 11 5 14 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_212527_133_477_- FIG00016514 5 2 7 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_212528_1_271_- FIG00058830 14 4 14 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_212531_259_477_- FIG00018396 15 4 16 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_212561_158_477_- FIG01307086 63 9 63 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_212597_1_296_+ FIG00000314 6 3 8 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_212597_331_477_+ FIG00000352 15 4 17 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_212598_1_477_- FIG00138209 66 11 70 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_212608_32_433_+ FIG00001378 7 4 9 N-carbamoylputrescine amidase (3.5.1.53) Polyamine Metabolism 2 T2D_unique_212630_1_477_+ FIG00000402 11 4 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_212636_1_477_+ FIG00000280 101 16 103 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_212642_1_477_- FIG00003788 9 4 11 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_212654_1_426_+ FIG00001824 23 10 25 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_212662_1_342_+ FIG00000168 76 12 77 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_212669_34_477_- FIG00000017 98 14 98 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_212675_156_477_- FIG00091606 28 6 30 Methionine synthase activation domain (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_212705_1_477_- FIG00002561 124 18 124 RNA polymerase sporulation specific sigma factor SigH Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_212733_1_477_- FIG00000343 5 4 6 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_212754_1_477_+ FIG00138209 49 10 50 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_212785_1_477_- FIG00003894 13 5 15 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_212793_99_326_- FIG00138258 7 4 9 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_212793_331_477_+ FIG01304886 4 2 5 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_unique_212819_1_477_+ FIG00035175 20 6 22 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_212838_1_362_+ FIG00041038 9 3 10 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_212864_15_477_- FIG00031759 13 5 18 Periplasmic beta-glucosidase (EC 3.2.1.21) Beta-Glucoside Metabolism 2.bc T2D_unique_212874_1_477_+ FIG01260980 76 14 78 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_212881_1_477_- FIG00016110 16 7 18 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_212939_1_477_+ FIG00007079 6 4 8 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_212940_44_313_- FIG00229216 56 9 56 Diacylglycerol kinase (EC 2.7.1.107) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_212944_308_477_+ FIG00002011 24 5 25 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_unique_212958_262_477_- FIG00002470 13 3 14 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_212991_1_324_+ FIG00001020 22 6 23 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_212996_1_477_+ FIG00080231 120 17 120 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_213009_1_476_+ FIG00136692 30 6 31 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_213021_1_476_+ FIG00000763 4 3 6 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_213030_70_476_+ FIG00002968 38 10 40 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_213035_151_453_- FIG00000279 22 5 23 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_213044_196_476_+ FIG00001011 46 9 47 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_213074_1_476_- FIG00000111 108 17 109 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_213107_1_476_+ FIG00000001 34 9 37 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_213125_264_476_- FIG00000081 55 8 55 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_213138_1_476_+ FIG00000522 107 16 107 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_213145_1_476_+ FIG00006117 102 16 104 Agmatine/putrescine antiporter, associated with agmatine catabolism Polyamine Metabolism 2 T2D_unique_213148_1_376_+ FIG00018699 47 8 48 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_213151_348_476_- FIG00044622 12 3 12 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_213154_1_476_- FIG00001469 13 4 18 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_213174_1_476_+ FIG00000095 115 17 115 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_213175_1_302_+ FIG00016566 18 6 20 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_213177_1_476_- FIG00016286 9 3 11 Ribosyl nicotinamide transporter, PnuC-like Cobalt-zinc-cadmium resistance 1.26 T2D_unique_213183_116_476_+ FIG00000095 41 9 42 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_213185_251_476_+ FIG00000208 6 2 7 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_213186_64_476_- FIG00046929 24 7 25 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_213214_1_476_- FIG00041038 9 4 12 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_213240_1_476_+ FIG01260980 5 4 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_213269_1_201_+ FIG01312219 24 4 25 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_unique_213288_1_476_+ FIG00000075 20 7 22 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_213289_1_476_- FIG00000494 7 4 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_213296_98_476_+ FIG00000028 44 9 45 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_213327_1_476_- FIG00000842 62 13 65 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_213334_1_427_- FIG01297554 50 10 52 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_213340_1_230_- FIG00001635 9 2 10 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_213344_1_237_- FIG00521176 41 8 41 fructose response regulator of fruA and EII fructose/mannose Fructose and Mannose Inducible PTS 2 T2D_unique_213344_278_476_- FIG00139735 52 7 52 fructose sensor histidine kinase Fructose and Mannose Inducible PTS 2 T2D_unique_213375_73_476_+ FIG00181043 3 4 13 Pullulanase (EC 3.2.1.41) Maltose and Maltodextrin Utilization 1.x T2D_unique_213402_131_476_+ FIG00000532 28 6 29 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_213430_1_476_- FIG00138258 16 4 18 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_213459_1_476_- FIG00000861 127 18 127 Gluconokinase (EC 2.7.1.12) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_213461_1_476_+ FIG00000532 53 12 55 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_213470_1_433_- FIG00135554 10 4 14 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_213497_1_473_+ FIG00018176 3 2 4 Phospholipid-lipopolysaccharide ABC transporter N-linked Glycosylation in Bacteria 2.0 T2D_unique_213518_1_476_+ FIG00002541 115 18 116 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_213522_1_476_- FIG00001932 31 8 32 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_213532_1_476_+ FIG00051439 43 10 45 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_213538_1_284_+ FIG00085740 74 11 74 N-acetylhexosamine 1-kinase Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_213542_1_171_- FIG00000194 13 4 14 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_213556_1_186_- FIG00018699 37 6 37 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_213558_147_476_- FIG00028461 24 5 25 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_213560_1_476_+ FIG00001547 125 18 125 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_213567_1_378_- FIG00000163 6 4 8 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_213590_1_476_+ FIG00719736 26 10 27 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_213596_1_183_+ FIG00018396 27 5 28 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_213598_1_476_- FIG00088067 21 6 24 Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_213617_1_476_+ FIG00003086 17 6 18 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_213620_1_476_- FIG00000032 24 6 25 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_213627_1_476_- FIG00001384 128 18 128 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_213650_1_476_- FIG00945384 61 13 62 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_213666_1_476_- FIG01260980 60 10 61 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_213681_1_476_+ FIG00000594 60 12 62 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_213685_1_334_- FIG01266244 15 6 17 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_213702_1_475_+ FIG00132801 28 8 29 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_213733_182_475_+ FIG00010844 29 7 30 Flavodoxin Flavodoxin 1 T2D_unique_213741_1_475_+ FIG00092725 21 10 42 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Anaerobic respiratory reductases 3 T2D_unique_213796_1_475_+ FIG00016514 25 8 33 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_213830_290_475_- FIG00058830 10 2 11 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_213850_1_475_+ FIG00001469 117 18 117 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_213857_1_475_+ FIG00000043 114 18 114 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_213861_214_475_+ FIG00000025 64 10 64 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_213906_1_475_+ FIG00001088 13 4 15 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_213922_1_475_- FIG00060517 13 6 19 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_213960_1_257_+ FIG00000304 51 9 53 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_213982_1_450_+ FIG00140555 19 5 22 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_214038_1_202_- FIG00011468 5 4 7 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_214049_163_475_- FIG00016514 45 8 46 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_214063_1_475_- FIG00002992 17 6 25 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_214064_1_475_- FIG00019890 56 9 57 Predicted amino-acid acetyltransferase (EC 2.3.1.1) complementing ArgA function in Arginine Biosynthesis pathway Arginine Biosynthesis extended 1.0 T2D_unique_214084_1_247_+ FIG00003751 4 3 5 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_214089_317_475_- FIG00000095 21 4 22 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_214104_72_350_- FIG00018699 4 3 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_214110_1_475_+ FIG00000372 19 5 21 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_214122_1_475_+ FIG00000102 125 19 125 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_214137_76_318_- FIG00029916 42 8 43 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_214153_1_230_- FIG00000449 5 2 6 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_214164_1_475_- FIG00000575 15 4 17 L-aspartate oxidase (EC 1.4.3.16) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_214186_18_475_- FIG00000015 10 5 11 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_214255_1_475_+ FIG00137522 15 5 16 Glucosamine-6-phosphate deaminase [isomerizing], alternative (EC 3.5.99.6) Chitin and N-acetylglucosamine utilization 2 T2D_unique_214263_1_475_+ FIG00138741 46 10 47 Aldehyde dehydrogenase B (EC 1.2.1.22) Methylglyoxal Metabolism 3.x T2D_unique_214269_1_475_+ FIG00644514 37 8 38 Putative cytochrome C-type biogenesis protein Biogenesis of c-type cytochromes 1.1 T2D_unique_214299_1_475_+ FIG00000532 12 3 14 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_214344_270_475_+ FIG00005727 13 3 14 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_214354_233_475_- FIG00088533 42 8 44 Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Cobalamin synthesis 2 T2D_unique_214394_1_474_+ FIG00001834 7 5 9 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_214406_1_474_- FIG00085033 49 8 50 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_214417_1_450_+ FIG00000107 25 8 26 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_214430_1_474_+ FIG00001168 62 13 63 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_214432_1_340_- FIG00000211 79 12 79 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_214463_1_474_- FIG00001548 5 2 10 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_214464_115_474_+ FIG00037431 91 14 91 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_214471_1_474_+ FIG00451095 15 7 16 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_214487_1_425_+ FIG00091940 77 13 78 Histidine ammonia-lyase (EC 4.3.1.3) Histidine Degradation 1.100 T2D_unique_214532_1_474_+ FIG00007586 5 2 8 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_214535_1_474_+ FIG00002914 3 5 30 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_214551_66_224_+ FIG00000155 34 6 34 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_214558_163_474_- FIG00012067 62 10 63 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_214603_1_474_+ FIG00000309 18 5 20 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_214617_1_255_- FIG00000832 7 3 9 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_unique_214620_1_474_- FIG00000043 68 11 69 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_214655_47_474_- FIG00001366 14 7 15 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_214677_1_474_+ FIG01260980 36 9 38 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_214683_1_474_- FIG00000448 129 19 129 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_214689_1_474_- FIG01239241 4 4 7 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_214701_1_474_+ FIG00006764 20 4 23 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_214712_231_474_- FIG00005840 34 7 35 Phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_214723_1_474_+ FIG00047509 53 11 54 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_214724_1_474_- FIG00001687 122 17 122 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_214732_1_474_+ FIG00005022 19 6 27 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_214739_1_474_+ FIG00000777 15 5 16 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_214752_1_279_- FIG00000261 69 11 69 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_214767_321_474_- FIG00135315 6 3 7 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_214792_1_474_+ FIG00000402 9 3 10 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_214796_1_474_- FIG00016514 13 7 15 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_214798_1_474_- FIG00018457 90 15 91 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_214814_304_474_- FIG00009038 20 4 21 D,D-heptose 7-phosphate kinase Capsular heptose biosynthesis 1 T2D_unique_214815_17_474_- FIG01291525 19 10 64 Fibronectin-binding protein Streptococcus pyogenes recombinatorial zone 8 T2D_unique_214884_1_474_- FIG00000221 108 18 108 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_214885_1_474_+ FIG00132770 13 4 15 Prephenate and/or arogenate dehydrogenase (unknown specificity) (EC 1.3.1.12)(EC 1.3.1.43) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_214907_1_474_- FIG00076542 98 17 99 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_214923_214_474_- FIG00000402 10 3 11 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_214942_1_390_+ FIG00000312 58 11 59 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_214943_1_261_- FIG00001388 13 3 14 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_unique_214951_1_239_- FIG00000165 26 6 27 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_214964_1_338_+ FIG00007694 3 2 4 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_214982_86_474_+ FIG00002020 69 12 70 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_215005_1_474_- FIG00001054 25 7 27 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_215009_1_474_+ FIG00000301 37 9 39 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_215031_1_474_- FIG00006997 53 11 57 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_215071_1_473_- FIG00000464 28 8 30 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_215096_63_473_+ FIG00001385 26 6 28 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_215103_1_392_+ FIG00000088 12 4 14 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_215130_202_473_- FIG00019251 44 8 45 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_215165_1_473_- FIG00134889 47 10 49 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_215172_1_146_+ FIG00000343 11 2 12 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_215175_1_137_+ 30 5 30 ErfK/YbiS/YcfS/YnhG family protein Copper homeostasis 12 T2D_unique_215177_1_473_- FIG00000065 6 2 8 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_215197_235_473_- FIG00004453 11 3 12 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_215244_143_473_- FIG00000721 33 6 34 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_215274_219_473_+ FIG00000494 17 4 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_215283_1_473_- FIG00001469 33 10 35 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_215304_1_323_- FIG00181043 7 2 9 Pullulanase (EC 3.2.1.41) Maltose and Maltodextrin Utilization 1.x T2D_unique_215317_227_473_+ FIG00000583 63 9 63 RNA-binding protein Hfq Hfl operon 1.111 T2D_unique_215325_44_473_- FIG00846773 23 6 26 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_215347_52_473_- FIG00000793 52 12 53 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_215363_1_473_+ FIG00000132 13 3 14 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_215370_215_473_+ FIG00138182 18 4 20 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_215381_1_314_+ FIG00025213 69 12 69 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily A1 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_215389_1_473_+ FIG01260980 117 18 118 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_215410_1_473_- FIG00000387 86 15 87 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_215413_1_188_- FIG00001642 38 6 38 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_215426_7_473_- FIG00007514 8 4 9 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_215514_1_473_- FIG00001732 28 6 29 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_215518_1_473_- FIG00000047 36 7 38 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_215554_1_473_- FIG00687285 25 6 26 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_unique_215557_1_473_- FIG00000793 58 12 60 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_215573_1_473_+ FIG00050243 4 2 5 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_215603_1_359_- FIG01955902 66 10 67 Rubredoxin Rubrerythrin 2 T2D_unique_215610_1_430_+ FIG00000101 62 12 65 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_215654_188_473_- FIG00017465 49 10 50 3'-to-5' oligoribonuclease B, Bacillus type RNA processing and degradation, bacterial 1 T2D_unique_215685_1_473_- FIG00000113 39 9 41 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_215717_26_301_+ FIG00023268 31 8 31 DNA-binding protein HU-beta DNA structural proteins, bacterial 1.1100 T2D_unique_215722_77_322_- FIG00000013 42 7 42 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_215749_311_473_- FIG00059426 4 2 10 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_215755_28_472_+ FIG00000277 25 7 26 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_215757_249_472_+ FIG00008736 8 2 9 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_215777_1_404_- FIG00000402 22 7 23 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_215793_307_472_+ FIG00001388 10 3 12 Sugar/maltose fermentation stimulation protein homolog Fermentations: Mixed acid 1 T2D_unique_215811_198_472_+ FIG01289411 4 2 6 Lactose and galactose permease, GPH translocator family Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_215816_274_472_- FIG00067562 9 4 11 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_215841_199_472_+ FIG01260980 7 2 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_215849_1_472_+ FIG00001022 101 16 102 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_215850_188_472_+ FIG00099318 5 2 6 RNA polymerase sigma factor SigV Transcription initiation, bacterial sigma factors 1 T2D_unique_215863_1_472_+ FIG00006868 4 2 5 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_215884_1_472_- FIG00042616 119 18 119 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_215886_326_472_- FIG00000367 6 3 8 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_215900_1_472_+ FIG00031969 118 18 118 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_215911_281_472_- FIG00026918 13 3 14 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_215918_1_472_+ FIG00001401 24 8 26 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_215927_1_472_- FIG00009682 26 10 28 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_215997_1_472_+ FIG00000076 101 16 101 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_216030_1_472_- FIG00000086 89 14 90 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_216055_6_472_- FIG01260980 114 16 115 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_216065_58_472_- FIG00000510 5 4 7 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_216075_1_472_+ FIG00146664 30 10 31 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_216100_258_472_+ FIG00000404 34 7 35 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_216102_208_472_+ FIG00000405 30 7 32 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_216117_1_378_+ FIG00052730 8 3 10 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_216129_1_353_- FIG00000088 91 13 91 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_216174_121_472_- FIG00000377 90 14 90 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_216175_1_472_+ FIG01260980 3 3 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_216180_1_472_+ FIG00004568 3 2 5 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Alkanesulfonate assimilation 9.? T2D_unique_216191_1_472_+ FIG00000863 7 3 12 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_216196_1_472_+ FIG00000317 59 10 60 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_216203_1_316_+ FIG00001366 58 10 59 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_216212_89_472_- FIG00080231 20 5 21 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_216237_135_472_+ FIG00139150 5 2 6 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit B p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_216260_163_472_- FIG00000207 22 6 34 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_216275_1_466_+ FIG00000263 64 12 65 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_216295_1_192_+ FIG00010454 15 4 16 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_216358_1_238_+ FIG00002652 52 8 52 CDP-glycerol: N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_216369_1_472_+ FIG00024401 21 6 23 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_216379_1_472_+ FIG01956356 18 4 25 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_216380_251_472_- FIG00000043 31 6 31 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_216408_1_472_+ FIG00046929 3 5 11 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_216411_1_472_- FIG00003251 91 16 92 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_216420_1_472_- FIG00133325 12 4 17 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_216429_1_392_- FIG00598409 48 9 51 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_216431_177_472_- FIG00026918 31 6 33 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_216448_1_472_+ FIG00000824 42 9 44 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_216492_1_471_+ FIG00000101 76 13 77 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_216531_1_471_+ FIG00000157 119 18 119 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_216545_90_471_+ FIG00000452 16 5 17 Chemotaxis protein methyltransferase CheR (EC 2.1.1.80) Bacterial Chemotaxis 9 T2D_unique_216557_1_250_- FIG00000212 23 7 24 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_216562_189_377_- FIG00001798 8 2 9 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_216568_166_471_- FIG00000442 8 4 10 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_216598_1_345_+ FIG00001203 11 2 12 Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_216636_1_471_+ FIG00000258 88 15 89 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_216681_1_471_+ FIG00000402 95 14 95 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_216685_1_301_- FIG00000494 29 6 30 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_216692_1_393_- FIG00000038 4 3 6 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_216695_1_146_+ FIG00000402 5 2 6 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_216726_1_257_- FIG00001029 27 6 28 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_216747_1_275_+ FIG00000368 20 5 22 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_216750_1_471_+ FIG00000036 61 10 62 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_216767_1_294_+ FIG00133139 31 8 32 Superoxide dismutase [Fe] (EC 1.15.1.1) Oxidative stress 1.2 T2D_unique_216785_1_471_- FIG00000372 3 3 4 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_216814_1_471_- FIG00003769 118 18 119 Stage III sporulation protein AE Sporulation Cluster III A 1.x T2D_unique_216817_9_471_- FIG00000025 24 5 25 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_216851_1_211_- FIG00000148 20 6 21 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_216853_1_471_+ FIG00000522 6 3 7 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_216875_321_471_- FIG00013339 40 6 40 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_216880_1_194_- FIG00000411 49 7 49 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_216894_1_471_+ FIG00031250 37 9 40 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_216897_1_241_- FIG00093180 12 2 13 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_216906_1_471_- FIG01307369 133 19 133 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) Cellulosome 1.x T2D_unique_216915_273_471_+ FIG00719736 11 3 12 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_216919_1_471_- FIG00047414 15 5 17 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_216925_1_427_- FIG00001020 114 16 114 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_216929_1_471_- FIG00000680 67 12 68 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_216930_1_282_+ FIG00004917 63 10 63 Protein AraJ precursor L-Arabinose utilization 1 T2D_unique_216939_1_162_- FIG00000464 25 4 26 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_216939_247_471_- FIG00030191 39 7 39 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_216967_1_265_- FIG01304452 4 2 5 Serine protease (EC 3.4.21.-) CBSS-269801.1.peg.1715 1 T2D_unique_216974_56_471_+ FIG00013626 10 4 11 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_217011_1_471_- FIG00002194 124 18 124 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_217027_1_471_+ FIG00001188 27 6 28 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_217084_1_471_+ FIG00000156 13 4 15 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_217093_1_471_- FIG00719736 4 2 6 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_217127_1_341_- FIG00000877 31 8 32 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_217136_1_470_+ FIG00010600 23 5 24 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_217145_1_470_- FIG00001269 69 13 71 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_217180_1_470_- FIG00001548 14 2 16 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_217201_1_470_- FIG00093180 104 16 104 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_217202_1_325_+ FIG00136447 7 3 8 Hypothetical nudix hydrolase YeaB Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_217214_1_470_+ FIG00136193 57 12 59 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_217224_1_470_- FIG00133325 109 18 109 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_217229_1_470_+ FIG00000494 8 3 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_217235_1_343_+ FIG00020897 15 4 16 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_217271_1_470_+ FIG00132839 68 12 70 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_217283_1_386_+ FIG00000721 109 15 109 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_217331_1_426_- FIG00455853 3 3 10 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_217336_1_470_+ FIG00077620 31 7 32 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_217339_1_470_+ FIG00005111 31 6 33 Nitrogen regulatory protein P-II Ammonia assimilation 1 T2D_unique_217341_219_470_- FIG00031250 45 8 46 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_217343_1_429_+ FIG00006465 8 3 10 Nickel transport ATP-binding protein NikD (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_217345_1_470_- FIG00001384 7 5 8 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_217353_1_470_- FIG00001530 4 3 6 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_217356_1_470_- FIG00096593 126 18 126 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_217387_1_470_- FIG00002273 4 2 5 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_217423_1_438_+ FIG00011468 67 12 68 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_217451_1_470_+ FIG00000448 127 18 127 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_217455_1_470_+ FIG00135025 12 6 14 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_217459_169_470_- FIG00000309 13 4 14 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_217486_1_470_- FIG00042267 82 15 83 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_217488_1_470_+ FIG00001548 39 10 40 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_217489_1_470_- FIG00453259 35 9 36 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_217494_1_470_+ FIG00000087 45 11 46 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_217502_1_337_+ FIG00003251 10 4 12 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_217517_1_470_- FIG00003433 76 15 76 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_217533_1_470_- FIG01304601 8 2 9 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_217537_200_470_- FIG00064110 38 8 38 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_217588_1_158_- FIG00003788 5 4 6 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_217590_1_470_- FIG00001469 7 4 9 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_217593_79_470_- FIG00000445 6 4 8 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_217627_1_470_+ FIG00000777 9 3 11 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_217629_1_470_+ FIG00041038 9 3 11 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_217635_1_470_+ FIG00000539 55 11 56 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_217665_1_470_- FIG00003955 64 12 65 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_217687_1_228_- FIG00085033 4 3 9 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_217689_1_470_- FIG00085033 124 17 124 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_217714_1_280_- FIG00000370 57 9 57 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_217720_1_470_+ FIG00046929 129 18 129 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_217728_1_470_- FIG00034851 19 5 20 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_217730_123_470_- FIG00135469 8 5 9 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_217733_250_470_+ FIG00003520 5 3 6 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_217766_193_470_+ FIG00000672 22 6 23 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_217771_1_470_+ FIG00005022 36 8 37 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_217783_1_470_- FIG00031250 16 5 18 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_217795_1_470_+ FIG00001649 103 15 104 N-methylhydantoinase A (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_217820_331_470_+ FIG00000825 17 4 18 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_217824_1_469_- FIG00000463 47 9 49 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_217837_1_469_+ FIG00000069 15 5 16 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_217854_1_469_+ FIG00000188 5 2 8 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_217856_1_469_- FIG00451095 43 9 45 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_217863_1_469_- FIG01307086 20 5 22 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_217867_1_469_+ FIG00129616 41 11 42 GTP-binding protein EngA Universal GTPases 2 T2D_unique_217884_30_469_+ FIG00000383 28 5 29 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_217899_1_469_+ FIG00745599 57 12 58 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_217920_1_469_+ FIG00000356 122 19 122 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_217940_1_469_- FIG00000114 21 7 32 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_217948_1_456_+ FIG00093180 21 7 22 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_217970_1_469_+ FIG00070513 4 2 6 phosphotransbutyrylase (EC 2.3.1.19) Acetyl-CoA fermentation to Butyrate A T2D_unique_217986_11_469_- FIG00000840 46 8 47 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_217996_1_422_- FIG00000401 19 6 21 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_217997_1_469_+ FIG00007514 12 6 18 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_218021_1_228_- FIG00003460 49 8 49 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_218031_1_469_- FIG00006463 10 4 12 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_218040_144_469_+ FIG00001253 16 4 17 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_218045_1_469_- FIG00140555 9 4 12 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_218046_1_469_- FIG00000695 4 2 6 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_218047_1_469_+ FIG00000520 11 4 15 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_218058_1_469_+ FIG00000168 124 18 124 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_218068_194_469_+ FIG00010844 7 2 8 Flavodoxin Flavodoxin 1 T2D_unique_218123_1_300_+ FIG01955850 44 7 45 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_218124_1_469_- FIG00005243 3 3 8 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_218168_1_469_- FIG01260980 101 17 101 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_218190_1_469_- FIG00074225 3 3 4 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_218204_1_223_+ FIG00000141 20 5 21 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_218209_1_469_- FIG00005216 49 9 55 Sulfate permease Cysteine Biosynthesis 2.17 T2D_unique_218226_1_322_- FIG00042267 25 4 25 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_218227_38_469_- FIG00093180 15 4 16 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_218242_1_469_+ FIG00003433 104 15 104 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_218254_61_469_- FIG00000097 49 10 50 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_218257_1_377_+ FIG00000402 76 13 76 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_218266_1_469_- FIG00000434 28 7 29 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_218290_1_469_- FIG00000147 12 7 14 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_218294_1_469_- FIG00945384 9 3 11 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_218295_142_469_- FIG00614545 5 2 6 Acylphosphate phosphohydrolase (EC 3.6.1.7), putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_218299_1_322_+ FIG00000404 12 3 13 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_218300_136_469_- FIG00000260 5 2 6 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_218336_1_277_- FIG00000098 7 2 10 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_218356_137_469_+ FIG00001221 4 2 5 Alkanesulfonates-binding protein Alkanesulfonates Utilization 20 T2D_unique_218362_1_469_- FIG00000130 22 6 23 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_218383_1_469_+ FIG00067681 43 7 44 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_218387_1_130_+ FIG00000223 19 4 19 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_218397_233_469_- FIG00011622 56 9 56 Substrate-specific component ThiT of thiamin ECF transporter ECF class transporters 345678 T2D_unique_218400_32_469_- FIG00052730 117 17 118 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_218408_1_469_- FIG00029916 92 15 93 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_218413_172_469_+ FIG00045144 7 3 9 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_218423_1_469_+ FIG00002020 51 8 53 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_218469_1_469_+ FIG00001865 35 8 36 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_218473_1_381_- FIG00000370 83 13 84 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_218496_1_406_+ FIG00000986 62 11 63 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_218504_1_226_+ FIG00006463 39 8 39 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_218520_131_468_- FIG00001457 61 10 62 PTS system, galactitol-specific IIB component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_unique_218534_1_291_+ FIG00099318 38 8 40 RNA polymerase sigma factor SigV Transcription initiation, bacterial sigma factors 1 T2D_unique_218543_1_468_- FIG00000368 28 8 29 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_218550_1_468_+ FIG00005022 129 19 129 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_218552_1_154_- FIG00451095 6 2 7 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_218552_164_468_+ FIG00000387 24 6 25 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_218554_295_468_+ FIG00005022 35 6 35 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_218556_1_468_- FIG00003448 117 18 117 Anaerobic nitric oxide reductase flavorubredoxin Nitrosative stress 4 T2D_unique_218572_1_468_- FIG00060517 8 6 16 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_218593_1_468_- FIG00000402 134 19 134 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_218612_1_468_+ FIG00002130 101 16 102 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_218640_1_468_- FIG00062054 37 9 39 Putative glycosyltransferase protein CBSS-258594.1.peg.3339 1 T2D_unique_218642_1_468_- FIG00002020 120 18 120 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_218646_202_468_- FIG00034851 19 5 20 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_218657_1_257_- FIG00000377 31 5 32 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_218692_1_257_- FIG00023943 5 2 6 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_218719_1_468_- FIG00000453 37 7 38 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_218720_1_468_+ FIG00067681 137 19 137 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_218729_160_414_+ FIG00229257 29 5 30 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_218771_1_468_+ FIG00000476 35 9 36 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_218774_1_414_+ FIG00451095 26 7 27 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_218789_1_468_- FIG01260980 7 4 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_218795_56_468_- FIG00000269 106 16 106 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_218800_1_468_+ FIG00001712 22 7 43 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_218830_1_468_- FIG01290653 5 5 7 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_218838_1_411_- FIG00018699 29 8 32 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_218863_182_454_+ FIG01260980 9 2 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_218871_1_468_+ FIG00000425 25 9 29 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_218885_30_468_- FIG00135025 7 5 8 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_218904_1_222_+ FIG00000402 47 7 47 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_218941_1_468_- FIG00000877 45 10 46 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_218945_1_419_+ FIG00045144 62 14 63 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_218959_1_350_+ FIG00003955 21 6 24 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_218971_1_133_- FIG00002718 8 3 9 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_218972_29_322_+ FIG00005628 29 7 31 KH domain RNA binding protein YlqC KH domain RNA binding protein YlqC 1.11 T2D_unique_218978_124_468_+ FIG00052605 26 6 29 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_218995_292_468_+ FIG00021289 40 7 40 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_219031_154_468_+ FIG00001298 3 2 5 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_219034_169_468_- FIG00024546 5 3 6 Phosphonoacetaldehyde hydrolase (EC 3.11.1.1) Phosphonate metabolism 1 T2D_unique_219040_1_468_+ FIG00000402 122 17 122 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_219045_176_468_+ FIG00000835 32 6 34 NAD-dependent malic enzyme (EC 1.1.1.38) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_219048_1_354_+ FIG00017615 97 13 97 Universal stress protein family Universal stress protein family 1 T2D_unique_219122_18_468_+ FIG00000039 77 13 78 Translation elongation factor Tu Translation elongation factors bacterial 1.1 T2D_unique_219143_1_278_+ FIG00006997 59 9 60 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_219144_1_355_- FIG00002564 8 3 9 Polyphosphate glucokinase (EC 2.7.1.63) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_219182_1_468_+ FIG00000080 19 6 21 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_219202_1_467_+ FIG00001548 128 18 128 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_219207_1_300_+ FIG00126843 29 6 31 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_219221_1_467_+ FIG00000111 39 8 40 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_219240_77_467_+ FIG00066425 75 12 76 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_219250_185_467_+ FIG00009544 5 3 7 Late competence protein ComEA, DNA receptor Gram Positive Competence 3100 T2D_unique_219268_250_467_- FIG00001449 10 4 12 Xanthine phosphoribosyltransferase (EC 2.4.2.22) Xanthine Metabolism in Bacteria 1.0 T2D_unique_219289_165_467_- FIG00002719 64 10 64 Peptide chain release factor homolog Translation termination factors bacterial 1.13 T2D_unique_219342_1_467_+ FIG00001547 17 6 18 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_219371_85_467_+ FIG00000241 30 8 31 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_219410_44_467_+ FIG00003530 38 8 39 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_219422_54_467_- FIG00049097 23 5 24 Heavy metal RND efflux outer membrane protein, CzcC family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_219443_127_467_- FIG00002803 17 6 18 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_219444_173_467_- FIG00021644 5 2 7 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_219452_1_156_- FIG00009450 24 4 24 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_219452_219_467_- FIG00047414 63 9 63 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_219455_1_467_+ FIG00042267 6 6 19 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_219464_131_467_+ FIG00001198 8 2 9 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_219475_1_467_+ FIG00062547 68 10 70 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_219489_1_467_+ FIG00000494 17 5 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_219519_1_311_+ FIG00000116 18 4 19 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_219546_111_467_+ FIG00000131 78 11 79 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_219563_1_320_- FIG00138538 32 7 33 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_219565_160_467_+ FIG00000392 29 4 31 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_219568_104_467_+ FIG00007960 8 4 10 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_219586_1_467_+ FIG00000343 124 18 124 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_219587_1_467_- FIG01310319 5 2 6 Exoenzymes regulatory protein AepA in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_219588_1_467_+ FIG00006278 39 9 41 Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) CBSS-316057.3.peg.3521 1 T2D_unique_219590_1_430_+ FIG00000116 13 2 14 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_219591_1_467_- FIG00002560 106 17 107 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_219592_1_454_+ FIG01260980 37 8 38 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_219604_1_467_- FIG00133325 29 8 40 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_219620_183_467_+ FIG00138356 11 3 13 Translation initiation factor SUI1-related protein Translation initiation factors bacterial 1.111 T2D_unique_219656_1_467_- FIG00100472 5 2 7 Flavocytochrome c flavin subunit Flavocytochrome C 1 T2D_unique_219670_1_467_- FIG00000085 107 16 107 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_219675_1_381_- FIG00001548 8 3 9 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_219683_1_467_- FIG00046358 13 4 14 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_219689_1_467_+ FIG00000595 26 5 27 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_219695_1_467_- FIG00004078 15 3 16 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_219697_194_467_+ FIG00011537 59 10 59 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_219725_1_166_- FIG00000641 9 2 10 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_219731_1_467_- FIG00000521 8 4 9 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_unique_219741_1_399_- FIG00000112 13 4 14 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_219753_25_467_- FIG00003212 90 14 90 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_219766_1_384_+ FIG00093180 3 2 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_219768_211_467_- FIG00000402 4 2 6 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_219772_1_126_+ FIG00745599 11 3 12 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_219779_1_467_- FIG00003174 29 9 30 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_219781_1_164_+ FIG00000391 3 2 4 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_219820_1_467_- FIG00000112 59 12 61 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_219831_1_467_+ FIG00719736 60 10 61 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_219851_1_218_- FIG00071623 46 7 46 Naphthoate synthase (EC 4.1.3.36) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_219873_137_467_- FIG00000775 6 3 8 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_219889_1_286_- FIG00000659 12 4 13 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_219898_1_466_+ FIG00000080 20 8 24 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_219904_1_190_- FIG00001088 7 3 9 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_219918_1_466_+ FIG00073301 7 2 8 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_219956_1_466_- FIG00005587 18 5 19 Transcriptional regulator of rhamnose utilization, AraC family L-rhamnose utilization 1 T2D_unique_219965_1_466_- FIG00006165 12 5 13 Uracil-DNA glycosylase, family 4 Uracil-DNA glycosylase 1 T2D_unique_219971_1_465_+ FIG00001547 57 10 59 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_219978_1_143_- FIG00000113 25 4 26 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_219984_1_466_+ FIG00000101 42 9 44 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_220021_183_466_- FIG00003788 36 7 37 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_220025_1_357_- FIG00028476 11 4 13 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_220030_1_466_- FIG01260980 22 7 23 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_220078_1_466_+ FIG00000308 32 8 33 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_220093_1_393_+ FIG00000720 14 4 16 Cytidine deaminase (EC 3.5.4.5) Murein hydrolase regulation and cell death 1.2 T2D_unique_220094_1_365_- FIG00002799 4 2 6 Phosphoheptose isomerase 1 (EC 5.3.1.-) Capsular heptose biosynthesis 1 T2D_unique_220123_1_466_+ FIG00001548 69 13 91 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_220137_1_466_+ FIG01260980 12 5 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_220154_88_466_+ FIG00008591 42 8 44 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_220156_1_466_- FIG00041038 14 4 16 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_220159_1_466_+ FIG00018699 38 12 39 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_220164_1_466_+ FIG00002011 122 18 122 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_unique_220168_30_200_+ FIG00000325 7 3 8 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_220176_1_167_+ FIG00002805 22 4 23 Transcriptional regulatory protein RtcR RNA 3'-terminal phosphate cyclase 2 T2D_unique_220198_1_466_- FIG00071623 115 18 116 Naphthoate synthase (EC 4.1.3.36) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_220199_1_345_+ FIG00561498 92 13 92 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_220221_1_466_+ FIG00000539 42 10 44 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_220274_130_466_- FIG00503691 31 7 32 Cadmium-transporting ATPase (EC 3.6.3.3) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_220282_107_466_+ FIG00000224 12 3 14 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_220328_1_466_+ FIG00001548 7 2 9 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_220329_1_261_+ FIG00002416 5 2 6 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_220349_1_466_- FIG00001902 49 9 51 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_220412_1_466_+ FIG00000088 22 6 24 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_220415_179_466_- FIG00009156 10 4 11 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_220441_177_466_- FIG00000095 50 9 51 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_220445_1_466_+ FIG00001264 28 8 29 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_220450_1_150_+ FIG00000235 8 3 9 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_220454_255_466_- FIG00001088 16 4 17 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_220475_1_411_+ FIG00000088 102 16 102 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_220478_1_466_- FIG00719736 38 11 40 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_220480_1_307_+ FIG00000440 35 7 36 Pantoate--beta-alanine ligase (EC 6.3.2.1) Coenzyme A Biosynthesis A.191 T2D_unique_220486_1_466_+ FIG00003555 16 6 18 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_220501_1_466_- FIG00006997 115 18 115 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_220510_1_466_- FIG00029916 115 17 115 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_220523_170_466_- FIG00001067 21 5 22 Rubrerythrin Oxidative stress 1.2 T2D_unique_220534_1_369_+ FIG00000899 47 10 48 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_220543_1_466_- FIG00000134 132 18 132 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_220547_1_466_+ FIG00047056 26 8 28 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_220558_96_466_- FIG00004655 95 14 95 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_220559_1_306_+ FIG00002385 11 2 14 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_220562_308_466_+ FIG00000531 8 2 9 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_220579_1_422_+ FIG00028059 13 3 15 ATPase component CbiO of energizing module of cobalt ECF transporter ECF class transporters 345678 T2D_unique_220598_1_466_+ FIG00038814 84 14 85 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_220605_10_466_- FIG00000494 13 3 14 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_220608_1_466_- FIG00001642 126 18 126 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_220626_1_465_+ FIG00016061 3 3 5 L-lactate permease Lactate utilization 3 T2D_unique_220677_44_465_+ FIG00059211 3 3 5 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_220702_287_465_- FIG00001732 5 3 6 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_220722_1_465_- FIG00003212 96 16 98 D-glycero-D-manno-heptose 1-phosphate guanosyltransferase Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_220738_149_465_- FIG00018369 81 12 81 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_220774_1_443_- FIG00000289 23 7 28 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_220790_1_465_+ FIG00000402 23 5 24 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_220796_1_465_- FIG00086220 5 5 13 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_220831_1_438_+ FIG00000146 15 3 17 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_220884_1_465_+ FIG00003881 7 3 9 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_220898_1_465_- FIG00001548 14 3 16 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_220902_1_465_- FIG00000990 83 15 105 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_220912_1_465_+ FIG00003174 36 10 37 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_220915_1_465_+ FIG00003535 11 3 14 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_220922_295_465_+ FIG00000308 8 2 9 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_220930_1_369_+ FIG00000001 6 3 7 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_220968_1_465_- FIG00041382 71 11 80 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_220969_1_465_- FIG00000517 3 3 5 Iron-sulfur cluster-binding protein Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_220998_1_465_+ FIG00001902 16 6 18 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_221010_66_431_+ FIG00080955 31 8 32 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_221012_1_465_+ FIG00001166 5 3 7 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_221025_1_465_- FIG00455853 8 6 11 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_221029_95_445_+ FIG00004021 11 4 12 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_221032_1_453_+ FIG00001306 60 11 61 Ribosomal subunit interface protein Ribosome activity modulation 1 T2D_unique_221036_1_314_- FIG01260980 13 5 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_221039_297_465_+ FIG00080231 38 6 38 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_221046_1_465_+ FIG00000168 51 8 52 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_221071_1_400_- FIG00000140 19 8 21 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_221074_155_465_- FIG00001065 5 2 6 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_221084_1_465_- FIG00016514 28 5 29 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_221092_1_465_+ FIG01304430 6 3 7 putative ATP-dependent DNA helicase YjcD DNA repair, bacterial UvrD and related helicases 1 T2D_unique_221095_115_465_+ FIG00000173 78 13 78 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_221108_1_465_+ FIG00065780 17 4 19 Endo-1,4-beta-mannosidase Mannose Metabolism 2.0 T2D_unique_221119_1_465_+ FIG00000539 117 17 117 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_221124_317_465_+ FIG00138538 10 3 11 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_221137_141_465_+ FIG00004078 31 7 33 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_221151_1_465_- FIG00000038 73 13 74 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_221175_1_465_+ FIG00000911 9 3 10 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_221184_53_465_- FIG00000584 32 9 34 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_221197_1_288_- FIG00000303 70 11 70 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_221216_1_465_- FIG00002470 17 5 18 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_221240_1_465_- FIG00000116 18 6 20 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_221280_1_465_+ FIG00000459 12 5 14 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_221290_1_302_- FIG00000081 11 3 12 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_221294_1_465_- FIG00026137 118 18 118 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_221304_1_465_- FIG00000207 51 11 52 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_221340_1_378_- FIG00000177 83 14 84 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_221363_1_189_- FIG00001373 4 3 5 Na(+)-translocating NADH-quinone reductase subunit F (EC 1.6.5.-) Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_221378_1_464_- FIG00137972 115 17 115 Putative sucrose phosphorylase (EC 2.4.1.7) Maltose and Maltodextrin Utilization 1.x T2D_unique_221381_1_220_+ FIG00081563 51 8 51 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_221381_231_464_+ FIG00012267 23 6 36 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_221393_1_306_+ FIG00000522 52 9 53 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_221407_1_464_- FIG00000372 6 2 7 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_221413_1_174_- FIG00014000 24 6 25 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_221418_1_464_+ FIG00008507 27 6 28 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_221426_1_391_+ FIG00000990 14 4 16 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_221429_266_464_+ FIG00058830 12 3 14 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_221472_139_464_+ FIG00002161 88 13 88 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_unique_221478_277_464_+ FIG00095112 11 3 12 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) DNA-replication 4 T2D_unique_221482_1_464_- FIG00000504 80 15 82 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_221539_1_464_+ FIG00000130 14 4 15 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_221545_1_464_+ FIG00000402 81 14 82 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_221547_78_464_+ FIG00067681 15 7 24 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_221587_334_464_- FIG00001636 18 3 18 Maltose O-acetyltransferase (EC 2.3.1.79) Maltose and Maltodextrin Utilization 1.x T2D_unique_221601_1_244_+ FIG00001452 47 8 48 Transcriptional repressor of the fructose operon, DeoR family Fructose utilization 1 T2D_unique_221610_1_464_- FIG00003472 54 11 55 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_221621_1_464_+ FIG00000863 44 9 46 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_221655_1_464_+ FIG00074916 120 18 121 Acetolactate synthase, catabolic (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_221667_1_174_- FIG00000710 13 3 14 Alkyl hydroperoxide reductase protein C (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_221670_73_464_+ FIG00000145 91 14 92 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_221685_1_464_- FIG01260980 17 4 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_221705_1_464_- FIG00086697 6 4 17 Beta-1,3-glucosyltransferase LOS core oligosaccharide biosynthesis 1.x T2D_unique_221721_1_298_- FIG00139238 3 2 5 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_221736_181_464_- FIG00000652 18 5 19 Positive regulator of CheA protein activity (CheW) Bacterial Chemotaxis 9 T2D_unique_221759_9_392_+ FIG00014849 14 3 16 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_221763_1_464_+ FIG01260980 7 3 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_221828_190_464_- FIG00129616 12 3 13 GTP-binding protein EngA Universal GTPases 2 T2D_unique_221842_1_408_- FIG00035701 9 5 11 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_221857_1_222_- FIG00007714 44 7 44 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_221872_1_464_- FIG00001548 20 6 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_221894_1_464_- FIG00002870 35 5 36 L-fucose isomerase (EC 5.3.1.25) L-fucose utilization 1 T2D_unique_221928_290_464_+ FIG01318274 14 3 19 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_221936_232_464_+ FIG00000395 25 5 26 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_221942_1_464_+ FIG00000372 52 10 53 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_221952_1_409_- FIG00001577 18 5 21 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_221956_1_464_- FIG00000212 24 7 25 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_221959_16_464_+ FIG00016514 61 13 62 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_221964_29_464_- FIG01260980 82 13 83 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_221985_1_376_- FIG00000397 50 11 51 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_221994_1_373_- FIG00002968 47 7 48 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_221996_1_207_+ FIG00016110 36 5 37 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_222002_60_464_- FIG00003435 96 15 96 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_222027_1_464_- FIG00000387 111 17 111 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_222035_1_443_+ FIG00002839 3 3 5 MutS-related protein, family 1 DNA repair, bacterial MutL-MutS system 1 T2D_unique_222039_1_306_+ FIG00018369 40 7 41 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_222054_1_464_+ FIG00001547 13 4 14 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_222076_1_464_- FIG00139192 6 3 7 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_222094_1_463_+ FIG00138004 15 3 16 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_222099_179_463_+ FIG00044622 4 3 6 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_222131_1_463_+ FIG00000323 48 12 50 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_222143_1_157_- FIG00000756 8 3 10 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_unique_222155_1_463_- FIG01260980 6 3 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_222163_1_463_- FIG00019251 11 3 12 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_222169_184_463_- FIG00846773 58 10 58 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_222197_116_463_- FIG01260980 26 6 27 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_222213_1_463_- FIG00014079 102 15 103 HipA protein Persister Cells 1 T2D_unique_222253_1_401_- FIG00000260 36 10 37 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_unique_222263_273_463_+ FIG00134889 37 6 37 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_222268_1_463_+ FIG00000477 24 7 25 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_222274_54_463_+ FIG00000494 17 5 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_222277_1_463_- FIG00025216 16 7 17 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_222278_148_450_- FIG00066643 4 3 5 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_222290_1_371_+ FIG00001020 3 2 5 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_222303_1_463_- FIG00000043 111 17 112 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_222332_192_463_+ FIG00000163 18 4 21 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_222341_1_463_- FIG00010771 120 17 120 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_222362_1_182_- FIG00000101 23 4 24 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_222371_1_309_+ FIG00000464 14 5 16 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_222371_330_463_+ FIG00000047 10 3 12 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_222378_1_463_+ FIG00003894 29 9 33 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_222382_1_463_+ FIG00561498 15 3 16 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_222390_1_463_- FIG00012547 4 2 6 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) Biotin biosynthesis 1X T2D_unique_222401_273_463_+ FIG00002156 16 3 17 NG,NG-dimethylarginine dimethylaminohydrolase 1 (EC 3.5.3.18) Dimethylarginine metabolism 5 T2D_unique_222431_337_463_- FIG00000672 20 4 20 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_222437_1_463_+ FIG00000245 134 19 134 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_222439_1_463_- FIG00005283 46 12 48 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_222462_70_463_+ FIG00046929 101 14 101 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_222476_1_265_- FIG00022300 17 4 18 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_222505_290_463_+ FIG00000476 19 4 20 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_222528_1_289_+ FIG00000114 3 3 5 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_222532_1_463_- FIG01239241 5 2 7 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_222537_218_463_- FIG01955919 12 4 14 Thioredoxin Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_222542_1_181_- FIG00000011 6 3 7 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_222553_49_463_- FIG00000510 13 6 14 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_222565_1_463_- FIG00012531 3 3 5 TRAP-type transport system, small permease component, predicted N-acetylneuraminate transporter Sialic Acid Metabolism 1.x T2D_unique_222567_38_448_+ FIG00001980 37 9 38 Very-short-patch mismatch repair endonuclease (G-T specific) DNA repair, bacterial 3 T2D_unique_222604_1_164_+ FIG00034538 13 3 14 CRISPR-associated protein, Csm2 family CRISPR-associated cluster 1 T2D_unique_222604_176_463_+ FIG00006046 19 5 21 CRISPR-associated RAMP Csm3 CRISPR-associated cluster 1 T2D_unique_222614_1_463_- FIG00086220 12 5 14 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_222624_1_463_+ FIG00001237 11 4 12 Redox-sensitive transcriptional regulator (AT-rich DNA-binding protein) Oxidative stress 1.2 T2D_unique_222640_1_463_- FIG00000095 79 15 80 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_222665_1_459_+ FIG00561498 129 18 129 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_222696_52_463_- FIG00026137 105 16 105 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_222715_1_463_+ FIG00000764 33 6 35 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_222719_1_463_+ FIG00001548 4 2 5 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_222729_1_362_+ FIG01954097 25 5 28 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_222747_1_463_- FIG00000032 32 7 33 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_222761_1_463_+ FIG00109688 34 8 36 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_222764_1_463_+ FIG00000287 119 18 119 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_222782_292_463_+ FIG00000552 11 2 12 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_222784_1_151_- FIG00000040 36 6 36 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_222792_1_463_+ FIG01260980 94 16 95 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_222813_1_462_- FIG00002049 8 3 10 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_222821_240_462_+ FIG00134167 13 4 14 V-type ATP synthase subunit B (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_222827_23_462_- FIG00067681 34 7 37 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_222844_1_462_- FIG00001504 6 3 7 Serine--glyoxylate aminotransferase (EC 2.6.1.45) Serine-glyoxylate cycle 1 T2D_unique_222856_1_462_+ FIG00066643 4 2 5 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_222879_1_462_- FIG00028461 8 8 36 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_222944_258_462_+ FIG00001469 13 4 15 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_222969_38_462_- FIG00000396 3 2 5 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_223011_1_462_+ FIG00041038 17 5 19 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_223025_224_462_+ FIG00485890 14 2 15 FIG00820327: hypothetical protein Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_unique_223051_1_401_- FIG00002141 101 16 101 Competence protein CoiA Gram Positive Competence 3100 T2D_unique_223057_40_462_- FIG01260980 3 2 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_223060_1_462_+ FIG00138208 6 3 8 Glycolate dehydrogenase (EC 1.1.99.14), subunit GlcD Glycolate, glyoxylate interconversions ? T2D_unique_223066_1_144_+ FIG00132548 3 2 4 Thiol peroxidase, Bcp-type (EC 1.11.1.15) CBSS-316057.3.peg.3521 1 T2D_unique_223081_1_333_+ FIG00001577 34 6 37 LSU ribosomal protein L6p (L9e) Ribosome LSU bacterial 9 T2D_unique_223090_1_462_- FIG00000084 63 12 64 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_223108_1_462_+ FIG00009682 92 15 94 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_223109_137_462_+ FIG00005727 6 3 7 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_223117_1_462_+ FIG00000102 136 19 136 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_223134_3_462_- FIG00002239 124 17 125 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_223149_221_462_+ FIG00000659 62 9 62 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_223176_1_462_- FIG00001548 19 6 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_223208_1_462_- FIG00000402 108 17 108 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_223255_1_462_+ FIG00000695 20 5 22 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_223256_172_462_+ FIG00000198 36 8 37 LSU ribosomal protein L24p (L26e) Ribosome LSU bacterial 9 T2D_unique_223331_318_462_- FIG00001067 12 3 13 Rubrerythrin Oxidative stress 1.2 T2D_unique_223354_1_462_+ FIG00010600 9 3 11 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_223364_1_239_+ FIG00000168 10 3 11 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_223390_60_462_+ FIG00229386 22 4 24 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_223407_1_462_+ FIG00006418 111 18 111 ABC transporter, predicted N-acetylneuraminate transport system permease protein 2 Sialic Acid Metabolism 1.x T2D_unique_223423_308_462_+ FIG00106663 5 3 6 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_223429_1_462_- FIG00002020 131 18 131 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_223441_1_207_- FIG00001469 5 3 7 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_223441_248_462_+ FIG00006955 17 4 18 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_223471_1_462_+ FIG01288915 25 7 27 N-Ribosylnicotinamide phosphorylase (EC 2.4.2.1) NAD and NADP cofactor biosynthesis global E T2D_unique_223475_153_462_+ FIG00000164 52 8 53 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_unique_223480_1_462_- FIG00026750 29 7 31 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_unique_223486_1_462_- FIG00000539 58 11 59 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_223492_1_326_- FIG00088996 4 2 6 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_unique_223510_1_462_+ FIG00138004 15 4 19 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_223516_327_462_- FIG00000141 10 3 11 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_223550_1_175_- FIG00000594 6 3 8 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_223579_22_461_- FIG00000241 71 14 72 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_223583_1_207_- FIG00000043 25 6 26 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_223584_1_461_+ FIG00000107 94 15 95 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_223598_1_379_+ FIG00000532 28 9 29 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_223604_1_315_- FIG00019251 25 5 26 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_223617_107_295_- FIG00000645 10 2 12 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_223623_1_461_- FIG00041038 20 7 21 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_223642_1_461_+ FIG00001036 56 12 57 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_223643_1_187_+ FIG00139522 24 6 25 Predicted glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21), Actinobacterial type Glycogen metabolism 3 T2D_unique_223649_80_461_- FIG00561498 4 4 5 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_223662_1_461_+ FIG00136447 9 4 11 Hypothetical nudix hydrolase YeaB Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_223670_1_461_- FIG00001675 15 6 16 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_223675_1_461_- FIG00000402 3 2 4 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_223698_1_461_+ FIG00010262 34 9 36 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) EC699-706 1 T2D_unique_223719_1_461_+ FIG00000782 60 10 67 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_223726_1_224_- FIG00016768 10 4 11 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_223733_1_461_+ FIG00000494 27 5 28 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_223741_1_461_- FIG00000494 22 5 23 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_223752_1_461_- FIG00000085 31 8 32 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_223770_1_326_+ FIG00010675 6 4 11 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_unique_223789_10_264_- FIG00108342 19 4 21 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_223795_1_461_- FIG00133515 12 4 15 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_223812_152_461_+ FIG00001408 27 5 28 Rrf2 family transcriptional regulator Rrf2 family transcriptional regulators 4 T2D_unique_223847_1_461_- FIG00000477 134 18 134 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_223852_1_461_+ FIG00000404 3 2 6 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_223867_24_461_- FIG00000234 75 11 76 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_223878_172_461_+ FIG01956356 27 6 28 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_223888_1_461_+ FIG00001166 121 18 121 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_223899_168_461_- FIG00132967 73 11 73 Iron(III) dicitrate transport ATP-binding protein FecE (TC 3.A.1.14.1) Flavohaemoglobin 1 T2D_unique_223902_1_335_- FIG00121768 88 13 88 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_223914_266_461_- FIG00000401 35 7 35 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_223922_1_461_- FIG00001616 19 7 21 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_223929_273_461_+ FIG00001675 13 3 14 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_223933_1_444_+ FIG00010508 128 18 128 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_223935_1_461_+ FIG00002803 21 8 23 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_223951_1_461_+ FIG01304636 41 9 42 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_223954_47_461_- FIG00000015 24 8 26 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_223960_1_461_- FIG01260980 13 5 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_223984_1_147_+ FIG00044478 27 5 28 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_223993_38_461_+ FIG00016566 92 15 93 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_223994_1_461_+ FIG00085033 9 4 11 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_224017_1_461_+ FIG01260980 19 8 20 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_224029_1_461_- FIG00001547 129 18 129 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_224035_26_461_- FIG00001469 4 3 6 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_224054_36_461_- FIG00007514 5 2 6 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_224065_1_461_+ FIG00131476 22 8 24 RecD-like DNA helicase Atu2026 DNA repair, bacterial RecBCD pathway 3 T2D_unique_224066_1_461_+ FIG01304636 43 10 45 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_224101_1_296_+ FIG00000476 23 6 24 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_224109_1_461_- FIG00050854 112 17 113 Tricarboxylate transport protein TctC Tricarboxylate transport system 1.x T2D_unique_224128_1_461_- FIG00133229 30 9 31 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_224135_1_461_- FIG00051001 20 4 21 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Biotin biosynthesis 1X T2D_unique_224155_1_461_- FIG00000191 86 15 87 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_224178_1_461_- FIG00000277 10 3 11 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_224181_1_461_+ FIG00006463 121 18 121 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_224187_1_461_- FIG00130900 124 18 124 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_unique_224196_1_461_- FIG00093180 8 2 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_224202_1_461_- FIG00002252 89 16 89 Galactose/methyl galactoside ABC transport system, D-galactose-binding periplasmic protein MglB (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_224243_1_461_- FIG00139238 7 4 9 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_224269_1_461_+ FIG00041038 113 17 114 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_224275_1_442_+ FIG00018561 40 9 42 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_224282_1_461_- FIG00000268 76 13 77 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_224289_1_461_+ FIG00561498 131 18 131 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_224334_1_460_+ FIG00006151 32 10 33 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_224337_1_159_+ FIG00051439 14 4 15 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_224338_1_460_- FIG00024226 111 17 112 Ribose operon repressor D-ribose utilization A.123 T2D_unique_224353_1_460_+ FIG00000075 131 18 131 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_224367_1_460_+ FIG00000365 59 10 60 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_224378_1_290_- FIG00002239 25 5 26 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_224379_1_332_+ FIG00084105 32 7 33 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_224412_11_460_+ FIG00000636 107 17 108 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_224414_1_460_- FIG00041038 4 3 7 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_224415_72_460_- FIG00000333 12 5 15 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_224426_1_460_+ FIG00126843 126 18 126 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_224450_1_335_- FIG00047509 22 6 23 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_224490_1_460_+ FIG00028476 4 2 6 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_224492_1_460_+ FIG00073301 7 2 8 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_224512_1_460_- FIG00000636 37 11 40 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_224538_1_460_+ FIG00000332 39 8 41 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_224593_1_460_+ FIG00561498 73 10 76 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_224602_1_460_+ FIG00001547 8 3 12 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_224605_1_222_- FIG00001882 39 7 39 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_224605_225_460_- FIG00000704 54 8 54 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_224609_1_460_+ FIG00006691 95 16 96 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_224612_44_460_+ FIG00007957 18 6 20 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_224627_1_150_+ FIG00001076 8 3 9 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_224639_1_460_- FIG00554193 17 4 19 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_224646_1_460_+ FIG00002470 39 8 41 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_224652_1_416_+ FIG00000721 38 8 39 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_224659_1_460_+ FIG00109688 32 9 33 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_224663_1_199_+ FIG00121768 45 7 45 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_224668_1_460_+ FIG00001824 38 10 39 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_224679_1_268_+ FIG00080231 51 7 54 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_224746_1_460_- FIG00000111 41 10 42 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_224753_1_460_- FIG00138258 52 12 53 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_224757_1_429_+ FIG00945384 8 4 10 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_224758_17_460_+ FIG00031969 10 6 12 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_224777_1_460_+ FIG00138258 44 9 45 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_224778_1_460_+ FIG00134135 11 3 13 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_224836_1_460_+ FIG00076542 60 12 61 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_224839_1_460_+ FIG00000531 25 7 27 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_224861_98_460_+ FIG00010454 23 7 26 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_224882_31_460_- FIG00001676 87 14 88 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_224916_1_460_- FIG00029916 7 2 9 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_224934_1_294_+ FIG00000584 5 2 8 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_224938_1_460_- FIG00000383 38 10 39 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_224955_1_362_- FIG01955011 9 3 11 Hypothetical protein DUF454 Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_224981_1_460_+ FIG00002944 3 3 5 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_unique_224989_1_460_- FIG00000085 24 7 26 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_224992_1_460_+ FIG00000304 25 6 26 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_224999_1_226_+ FIG00000028 29 7 30 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_224999_256_460_+ FIG00000241 26 4 28 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_225023_65_459_- FIG00000474 4 4 7 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_225064_1_212_- FIG00455853 14 3 15 Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_225064_223_459_- FIG00945384 24 6 25 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_225099_94_459_+ FIG00000023 78 13 78 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_unique_225118_1_200_- FIG00000714 11 3 12 Membrane alanine aminopeptidase N (EC 3.4.11.2) EC 3.4.11.- Aminopeptidases 1 T2D_unique_225134_128_459_+ FIG00000088 47 8 48 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_225177_1_237_- FIG00000343 21 4 22 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_225184_200_459_+ FIG00023946 8 4 9 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_225188_1_459_+ FIG00080231 119 17 120 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_225199_252_459_- FIG00000252 31 5 31 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_225202_1_459_+ FIG00006128 100 17 101 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_225207_1_343_- FIG00000863 10 4 11 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_225238_1_201_+ FIG01955899 22 4 23 Cellobiose phosphotransferase system YdjC-like protein Beta-Glucoside Metabolism 2.bc T2D_unique_225257_277_459_- FIG00135469 3 2 6 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_225273_1_459_- FIG00008294 76 13 78 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_225280_1_459_- FIG00006764 18 4 19 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_225283_1_130_- FIG00008572 6 2 7 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_225298_1_225_+ FIG00126843 8 3 9 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_225307_1_459_- FIG00133870 51 12 78 Threonine dehydratase, catabolic (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_225361_1_459_+ FIG00018457 70 12 71 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_225383_1_459_- FIG00057709 116 18 116 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_225385_1_459_- FIG00000289 19 6 20 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_225386_1_459_+ FIG00026918 29 10 31 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_225405_1_459_- FIG00133209 23 6 24 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_225413_1_248_+ FIG00001469 46 7 47 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_225419_1_459_+ FIG00129616 66 13 68 GTP-binding protein EngA Universal GTPases 2 T2D_unique_225444_1_459_- FIG00000356 30 7 33 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_225448_1_410_+ FIG00453259 109 16 109 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_225475_1_459_+ FIG00000011 4 2 5 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_225483_1_459_+ FIG00000453 121 18 121 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_225495_49_282_- FIG00001385 14 4 16 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_225513_1_274_+ FIG00007514 60 9 67 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_225530_1_173_- FIG00006463 32 6 32 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_225541_1_459_+ FIG00000494 26 9 27 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_225575_1_459_- FIG00009210 110 16 111 FIG009210: peptidase, M16 family CBSS-257314.1.peg.676 4.x T2D_unique_225581_1_459_- FIG00000422 97 16 110 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_225598_1_459_- FIG00007059 97 15 98 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_225603_1_459_+ FIG00040890 112 17 112 tRNA-dependent lipid II-Ala--L-alanine ligase tRNA-dependent amino acid transfers 1 T2D_unique_225614_308_459_+ FIG00003086 8 2 9 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_225615_1_355_+ FIG00042627 5 2 7 Magnesium and cobalt efflux protein CorC Copper homeostasis: copper tolerance 3 T2D_unique_225617_70_459_+ FIG00000245 23 6 24 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_225621_1_445_+ FIG00623809 16 6 21 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_225627_1_459_- FIG00022300 18 5 20 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_225641_1_459_+ FIG00001474 131 19 131 Ribonuclease HIII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_225676_1_459_- FIG00000156 14 5 16 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_225708_1_410_+ FIG00006235 8 5 10 RND efflux system, outer membrane lipoprotein CmeC Multidrug Resistance Efflux Pumps 1.12 T2D_unique_225710_229_459_+ FIG00000812 3 3 5 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_225715_1_459_- FIG00006955 10 5 12 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_225729_49_459_- FIG00000261 73 12 74 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_225733_107_459_- FIG00000672 45 10 46 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_225742_37_458_+ FIG00133139 10 7 26 Superoxide dismutase [Fe] (EC 1.15.1.1) Oxidative stress 1.2 T2D_unique_225759_145_458_+ FIG00003535 74 11 74 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_225778_1_458_+ FIG00031250 74 11 75 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_225797_1_458_- FIG00016514 13 4 16 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_225814_226_458_+ FIG00000101 36 6 37 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_225830_68_458_+ FIG00003530 8 4 10 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_225836_1_458_+ FIG01260980 21 6 22 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_225838_1_458_+ FIG00000102 9 4 10 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_225842_1_163_- FIG00016566 8 2 9 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_225869_1_458_- FIG00008490 37 9 39 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_225872_1_458_+ FIG00000824 18 7 20 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_225873_1_458_+ FIG00001548 37 11 39 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_225930_1_447_+ FIG00451095 16 4 24 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_225939_1_369_+ FIG00394362 10 5 11 DNA for glycosyltransferase, lytic transglycosylase, dTDP-4-rhamnose reductase Rhamnose containing glycans 4.1 T2D_unique_225958_147_458_+ FIG00000277 25 7 26 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_225968_1_458_- FIG00001106 50 11 52 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_225973_1_458_+ FIG00000234 41 8 43 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_226084_1_458_- FIG00012945 99 17 99 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_226086_302_458_- FIG00008304 9 3 10 Aspartate 1-decarboxylase (EC 4.1.1.11) Coenzyme A Biosynthesis A.191 T2D_unique_226093_1_458_+ FIG00000402 25 7 26 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_226116_194_458_+ FIG00090765 58 10 58 Lactose and galactose permease, GPH translocator family Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_226121_1_458_+ FIG00046929 8 4 9 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_226148_1_458_+ FIG00000404 40 8 51 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_226208_1_458_+ FIG00000448 98 16 99 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_226211_1_458_- FIG00003972 6 2 7 FIGfam003972: membrane protein CBSS-269801.1.peg.1715 1 T2D_unique_226244_1_458_- FIG00028461 77 14 78 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_226254_1_458_- FIG00066643 8 3 10 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_226255_1_458_+ FIG00745599 42 9 43 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_226290_14_458_- FIG00025086 38 8 39 Xanthine permease Purine Utilization 1 T2D_unique_226292_1_320_- FIG00001088 80 12 80 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_226312_1_458_- FIG00002614 3 2 5 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_226325_1_458_+ FIG00000695 81 12 81 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_226394_1_458_- FIG00003881 108 16 109 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_226397_1_361_- FIG00000413 86 14 86 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_226405_1_458_+ FIG00000402 21 6 22 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_226416_1_458_+ FIG00000101 110 17 110 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_226422_1_234_+ FIG00017190 14 3 15 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_226433_1_458_- FIG00004233 66 11 67 DamX, an inner membrane protein involved in bile resistance Shikimate kinase containing cluster 1 T2D_unique_226516_1_401_- FIG00002049 3 3 4 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_226522_1_457_- FIG00146664 127 18 127 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_226525_1_286_+ FIG00000283 23 5 24 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_226538_1_307_+ FIG00004074 11 2 12 Ferredoxin-type protein NapG (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_226583_1_457_+ FIG00000578 13 4 14 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_226585_1_457_- FIG00004078 6 2 8 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_226593_1_457_+ FIG00018699 16 7 19 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_226600_223_457_+ FIG00139491 49 8 49 NAD-reducing hydrogenase subunit HoxE (EC 1.12.1.2) Hydrogenases 2 T2D_unique_226608_124_457_+ FIG00000770 60 10 61 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_226629_41_457_- FIG00067562 106 16 107 V-type ATP synthase subunit E (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_226634_1_457_- FIG00000001 100 16 100 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_226642_1_457_- FIG00073301 85 13 85 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_226655_95_457_- FIG00000112 7 4 9 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_226704_1_457_- FIG00002194 120 18 120 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_226709_119_457_- FIG00007586 3 2 4 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_226725_1_457_+ FIG00029916 14 4 15 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_226726_1_293_+ FIG00001264 12 3 13 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_226727_1_348_- FIG00133219 6 2 7 Thiamin biosynthesis lipoprotein ApbE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_226742_1_457_- FIG00000777 24 11 25 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_226744_1_457_- FIG00001932 5 3 6 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_226750_1_457_+ FIG01959389 11 3 12 PTS system, cellobiose-specific IIB component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_226753_165_457_- FIG00004528 44 8 45 Di-/tripeptide transporter Proton-dependent Peptide Transporters 1 T2D_unique_226781_1_409_+ FIG00134135 25 6 26 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_226794_1_296_- FIG00133219 17 3 19 Thiamin biosynthesis lipoprotein ApbE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_226812_1_457_- FIG00138538 3 2 5 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_226860_1_457_- FIG00003439 121 17 121 Spore maturation protein A Spore Core Dehydration 1.1 T2D_unique_226863_1_457_- FIG00000578 17 6 19 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_226869_120_457_+ FIG00018369 16 5 18 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_226888_1_229_- FIG00000555 26 5 28 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_226899_1_457_+ FIG00031969 124 18 124 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_226900_1_457_- FIG01260980 88 14 89 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_226924_74_445_+ FIG00091606 4 2 5 Methionine synthase activation domain (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_226927_102_457_+ FIG00024401 14 4 17 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_226969_1_310_+ FIG00079740 8 2 9 Xyloside transporter XynT Xylose utilization 1 T2D_unique_226975_1_457_+ FIG00029916 116 18 116 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_226987_1_457_+ FIG00000824 22 7 23 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_226997_214_457_+ FIG00000463 17 4 18 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_227000_1_457_+ FIG01260980 19 6 21 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_227036_1_457_+ FIG00002614 7 4 12 Chitin binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_227053_1_457_+ FIG00001819 116 18 116 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_227055_1_456_+ FIG00000148 38 10 39 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_227059_1_457_- FIG00001054 15 5 17 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_227070_1_457_- FIG00012349 6 4 11 Heme transporter analogous to IsdDEF, ATP-binding protein Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_227089_1_332_+ FIG00001385 20 6 21 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_227096_1_457_+ FIG00016110 10 3 12 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_227099_1_457_+ FIG00001548 32 7 33 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_227113_308_457_- FIG00120639 28 5 29 HTH-type transcriptional regulator IlvY Alanine biosynthesis A.123 T2D_unique_227128_1_457_- FIG00136866 108 17 109 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_227156_1_457_- FIG00010738 117 18 117 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_227157_1_457_- FIG00002463 76 15 78 Alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_227159_1_140_- FIG00000081 15 3 16 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_227197_131_457_- FIG00001198 92 13 92 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_227216_1_325_- FIG00000402 67 10 68 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_227219_173_456_+ FIG00000163 33 8 34 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_227236_1_177_+ FIG00139192 6 3 7 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_227236_195_456_+ FIG00049433 4 3 8 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_227247_1_456_- FIG00000372 24 5 26 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_227248_33_456_- FIG00015099 126 17 126 Similarity with glutathionylspermidine synthase (EC 6.3.1.8), group 2 Glutathionylspermidine and Trypanothione 9 T2D_unique_227262_179_456_+ FIG00002804 57 9 59 Homocysteine S-methyltransferase (EC 2.1.1.10) Methionine Biosynthesis 8 T2D_unique_227269_1_456_+ FIG00000128 5 2 6 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_227277_1_307_- FIG00011659 67 11 67 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_227277_324_456_- FIG00000962 22 4 22 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_227286_1_371_+ FIG01290653 3 2 4 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_227287_155_456_+ FIG00130900 12 4 13 Inner membrane protein translocase component YidC, short form OxaI-like Cell Division Subsystem including YidCD 1 T2D_unique_227292_1_237_+ FIG00000087 5 3 7 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_227301_1_450_+ FIG00007957 59 14 61 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_227342_1_281_- FIG00001548 27 5 28 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_227351_204_456_+ FIG00000028 8 2 9 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_227368_1_456_+ FIG00000782 21 6 23 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_227390_1_456_+ FIG00000422 125 18 125 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_227400_1_456_+ FIG00001530 21 5 24 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_227436_1_456_- FIG00001803 7 2 9 Polyferredoxin NapH (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_227455_230_456_+ FIG00000793 10 3 11 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_227487_56_456_+ FIG01260980 14 5 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_227492_1_456_+ FIG00075702 120 17 120 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_227511_1_240_+ FIG00007714 58 9 58 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_227515_1_456_- FIG00002344 48 9 50 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_227516_132_456_+ FIG00008907 13 4 14 Alpha-L-Rha alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_227526_44_456_- FIG00000672 30 8 41 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_227540_140_456_- FIG00084105 8 4 10 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_227561_1_438_+ FIG00000277 107 17 107 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_227570_1_456_- FIG00138258 121 17 121 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_227592_1_456_+ FIG00028461 24 7 25 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_227603_1_456_+ FIG00000087 114 17 114 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_227612_1_456_- FIG00000402 59 12 67 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_227619_1_456_- FIG00080231 43 10 45 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_227653_58_456_- FIG00003715 60 13 61 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_227697_289_456_+ FIG00076542 40 6 40 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_227698_1_456_+ FIG00000303 118 18 119 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_227711_1_456_- FIG00030688 92 16 94 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_227756_1_456_- FIG00000356 7 2 10 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_227764_1_456_- FIG00029916 4 3 6 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_227768_266_456_+ FIG00035175 3 2 4 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_227771_20_456_+ FIG00050603 129 17 129 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_227779_1_456_+ FIG00011537 8 3 11 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_227795_1_456_+ FIG01304636 27 8 30 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_227820_20_456_- FIG00000279 3 2 4 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_227829_1_406_- FIG00046929 83 13 84 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_227849_1_456_+ FIG01016270 39 9 42 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_227851_134_456_+ FIG00055520 55 10 55 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_227865_1_456_+ FIG00000376 4 2 5 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_227891_1_456_+ FIG00018699 7 3 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_227910_1_456_+ FIG00016514 65 11 67 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_227940_1_456_+ FIG00049433 4 3 8 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_227941_1_174_+ FIG00021289 21 5 22 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_227941_238_456_+ FIG00904859 35 6 36 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_unique_227950_1_134_- FIG00000404 23 4 23 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_227958_1_455_+ FIG00000056 119 18 119 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_227970_26_455_- FIG00000080 14 6 16 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_227971_1_219_+ FIG00000139 18 3 18 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_227991_1_455_+ FIG00001198 100 15 102 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_228020_1_455_+ FIG00011468 6 4 8 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_228031_1_455_- FIG00016514 43 11 45 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_228042_1_325_+ FIG00475203 73 10 74 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_228045_1_455_+ FIG01260980 8 2 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_228046_1_370_+ FIG00005727 11 4 13 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_228047_1_194_- FIG00009149 12 2 13 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_228056_185_455_+ FIG00003955 8 3 9 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_228090_1_455_- FIG00008941 74 13 75 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_228107_1_455_+ FIG00136692 43 7 45 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_228123_155_455_- FIG00000687 82 12 82 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_unique_228131_1_455_+ FIG00000532 29 8 31 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_228150_1_455_- FIG00003972 101 16 103 FIGfam003972: membrane protein CBSS-269801.1.peg.1715 1 T2D_unique_228170_1_455_+ FIG00001385 4 4 7 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_228189_1_455_- FIG00009544 5 2 7 Late competence protein ComEA, DNA receptor Gram Positive Competence 3100 T2D_unique_228198_1_382_- FIG01306479 19 5 21 TrmH family tRNA/rRNA methyltransferase YacO (EC 2.1.1.-) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_228201_1_455_+ FIG00000453 17 7 19 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_228237_222_455_+ FIG00000139 58 8 58 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_228259_1_164_+ FIG00001882 3 2 4 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_228260_1_455_+ FIG00011537 21 6 24 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_228267_1_455_+ FIG00034973 113 16 114 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_unique_228304_1_455_+ FIG00000134 24 5 26 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_228311_1_224_- FIG00000011 56 9 56 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_228319_267_455_+ FIG00000343 12 4 14 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_228325_1_455_+ FIG00001893 28 8 29 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_228338_1_209_- FIG00000404 36 8 37 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_228340_1_272_+ FIG00002716 29 5 30 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_228343_1_455_+ FIG00003251 69 12 69 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_228345_1_455_+ FIG00000015 27 8 29 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_228369_296_455_- FIG00000531 28 5 29 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_228371_1_455_- FIG00122145 9 4 11 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_228389_1_455_- FIG00001189 106 17 106 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_228392_1_455_- FIG00000043 67 12 68 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_228402_241_455_+ FIG00000032 8 2 9 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_228409_213_455_- FIG00000173 17 5 18 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_228429_218_455_+ FIG00000165 39 7 39 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_228440_1_455_- FIG00024851 58 12 59 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_228447_42_455_- FIG00000459 9 4 11 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_228458_1_455_+ FIG00034293 100 15 101 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_228460_1_455_+ FIG00000351 47 9 49 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_228464_1_262_- FIG00229386 23 4 24 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_228471_1_285_+ FIG00001675 65 10 65 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_228482_42_236_- FIG01303902 10 3 11 RNA polymerase sigma-70 factor Transcription initiation, bacterial sigma factors 1 T2D_unique_228502_1_455_- FIG00001189 33 9 35 Glycyl-tRNA synthetase (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_228529_1_455_- FIG00003474 8 4 9 Nucleoside permease NupC Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_228567_1_455_+ FIG00000131 13 5 15 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_228578_1_455_+ FIG00000139 15 3 17 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_228588_1_455_- FIG00846773 9 4 10 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_228632_267_455_- FIG00042616 8 2 9 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_228674_1_455_+ FIG00000085 118 17 118 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_228678_1_383_+ FIG00003175 99 15 99 Pyruvate:ferredoxin oxidoreductase, beta subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_228684_1_455_+ FIG00000308 128 18 128 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_228713_1_454_- FIG01260980 55 12 57 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_228767_1_454_+ FIG00000402 13 4 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_228782_1_454_- FIG00000146 41 11 43 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_228787_122_454_+ FIG00001385 15 5 16 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_228802_190_454_- FIG00229257 31 5 33 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_228803_182_454_- FIG00000985 49 8 50 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_228824_105_454_- FIG00075970 47 7 48 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_228841_1_454_+ FIG00059211 6 4 8 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_228859_135_454_- FIG00130344 11 2 13 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_228868_109_454_- FIG00005992 49 9 50 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_228878_1_454_- FIG00002194 125 18 125 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_228924_1_140_- FIG00028476 33 5 33 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_228937_1_383_- FIG00010738 6 3 9 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_228939_1_305_+ FIG00010844 21 5 22 Flavodoxin Flavodoxin 1 T2D_unique_229013_1_454_+ FIG00000897 34 6 36 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_229015_177_454_- FIG00001145 33 6 34 N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) Sialic Acid Metabolism 1.x T2D_unique_229017_1_454_+ FIG00000356 21 5 23 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_229018_1_316_+ FIG00036406 70 11 70 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_229026_1_454_- FIG00109688 131 18 131 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_229037_1_454_+ FIG00000449 27 7 28 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_229044_1_454_- FIG00000439 29 7 31 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_229055_1_454_+ FIG00004078 30 9 44 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_229069_1_410_- FIG00047509 42 9 43 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_229078_1_454_+ FIG00000113 37 10 39 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_229106_1_454_+ FIG00041038 28 8 30 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_229137_1_285_- FIG00126843 18 4 19 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_229138_1_454_- FIG00000165 19 5 21 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_229185_1_454_+ FIG00010908 9 2 10 CoB--CoM heterodisulfide reductase subunit C (EC 1.8.98.1) Anaerobic respiratory reductases 3 T2D_unique_229187_1_204_+ FIG00126843 11 2 12 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_229211_1_454_+ FIG00000273 17 3 18 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_unique_229229_1_454_+ FIG00000494 14 6 16 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_229238_1_454_- FIG00006463 60 12 60 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_229257_212_454_- FIG00000043 17 4 18 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_229272_62_406_- FIG00000134 29 6 31 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_229284_28_454_- FIG00000474 33 7 39 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_229286_1_407_- FIG00001548 20 5 22 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_229288_1_352_+ FIG00001088 19 5 20 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_229297_1_161_- FIG00080231 32 5 32 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_229308_1_454_+ FIG00018699 10 5 12 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_229328_260_454_+ FIG00000522 30 5 31 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_229357_1_454_+ FIG00001469 68 12 69 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_229374_1_454_+ FIG00075970 23 7 26 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_229387_1_454_- FIG00109688 10 4 12 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_229392_1_192_+ FIG00043259 12 3 14 Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_229392_257_454_+ FIG00001893 14 3 15 Inosose isomerase (EC 5.3.99.-) Inositol catabolism 5.x T2D_unique_229402_1_322_+ FIG00000474 20 6 21 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_229418_1_454_- FIG00006764 26 7 29 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_229430_180_454_- FIG00000356 3 2 4 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_229453_209_454_- FIG00001824 20 5 21 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_229463_1_453_- FIG00018457 4 2 6 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_229483_1_355_+ FIG00001522 25 6 27 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_229486_255_453_+ FIG00000408 31 5 32 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_229489_1_453_+ FIG00000289 104 16 105 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_229492_1_453_+ FIG00016566 17 5 19 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_229509_59_415_- FIG00009682 12 3 14 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_229513_1_453_+ FIG01307369 117 17 117 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) Cellulosome 1.x T2D_unique_229521_1_453_+ FIG00000173 35 8 36 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_229533_81_341_+ FIG00000301 25 6 27 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_229535_1_453_+ FIG00006092 107 18 107 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_unique_229545_1_453_+ FIG00001469 49 10 50 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_229584_162_453_+ FIG00000325 55 10 55 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_229589_1_453_+ FIG00000032 30 7 31 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_229614_1_453_+ FIG00000777 26 6 28 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_229621_1_324_- FIG00554193 5 4 7 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_229670_1_276_- FIG00000380 39 9 40 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_229700_83_453_- FIG00000762 57 10 58 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_229743_1_453_+ FIG00001548 22 6 24 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_229750_1_161_- FIG00031250 9 4 11 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_229759_181_414_+ FIG00035175 25 4 26 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_229771_1_453_- FIG00047056 87 15 89 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_229773_1_453_- FIG00007586 30 6 31 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_229781_1_453_+ FIG00080955 15 6 17 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_229800_1_453_- FIG00000967 100 14 101 Methylglyoxal synthase (EC 4.2.3.3) Methylglyoxal Metabolism 3.x T2D_unique_229810_1_259_+ FIG00059211 18 3 19 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_229819_1_453_+ FIG00059898 81 13 83 Assimilatory nitrate reductase large subunit (EC:1.7.99.4) Nitrate and nitrite ammonification 1 T2D_unique_229834_1_453_- FIG00002914 62 10 62 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_229861_1_393_+ FIG00000422 15 8 17 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_229870_1_453_- FIG00017190 9 4 11 Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family Zinc regulated enzymes 1 T2D_unique_229945_103_366_- FIG00000189 39 7 40 LSU ribosomal protein L27p CBSS-176279.3.peg.868 1.x T2D_unique_229962_1_453_- FIG00006336 130 18 130 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_229988_1_420_+ FIG00846773 17 6 18 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_229989_223_453_+ FIG00000001 56 9 56 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_230027_1_453_- FIG00000085 18 6 20 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_230031_1_453_- FIG00092725 29 9 31 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Anaerobic respiratory reductases 3 T2D_unique_230052_1_453_- FIG01260980 6 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_230106_1_347_- FIG00018699 8 3 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_230111_148_453_+ FIG00007339 86 12 86 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_230130_1_453_- FIG00000494 5 2 9 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_230161_1_453_+ FIG00126843 111 18 111 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_230168_1_221_- FIG00000013 29 6 30 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_230168_245_453_- FIG00047414 54 8 54 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_230180_1_453_- FIG00066643 97 14 99 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_230198_8_268_+ FIG00000433 7 2 8 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_230207_1_453_- FIG00018536 11 5 13 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_230211_247_453_+ FIG00134060 18 3 18 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_230219_43_453_+ FIG00015833 38 7 40 Oligosaccharide repeat unit polymerase Wzy Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_230223_1_453_- FIG01955818 39 10 40 Pyruvate:ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_230225_1_453_- FIG00000356 14 3 15 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_230245_81_452_- FIG00001385 72 11 73 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_230246_1_452_- FIG00000990 13 4 15 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_230253_1_358_- FIG00076542 6 3 8 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_230267_1_452_- FIG00133978 42 8 43 Ureidoglycolate dehydrogenase (EC 1.1.1.154) Allantoin Utilization X T2D_unique_230281_1_303_- FIG00001134 82 12 82 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_unique_230307_304_452_+ FIG00003535 3 2 4 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_230315_1_452_+ FIG00001642 15 6 16 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_230316_1_452_- FIG00018369 71 13 72 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_230327_1_452_- FIG00561498 3 2 4 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_230365_1_452_+ FIG00003520 31 8 32 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_230385_1_452_- FIG00000390 39 8 40 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_230398_1_452_+ FIG00014000 31 9 36 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_230402_1_452_+ FIG00003129 110 18 110 Galactose operon repressor, GalR-LacI family of transcriptional regulators Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_230416_237_452_- FIG00005840 44 6 44 Phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_230431_291_452_- FIG00000476 3 2 4 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_230441_1_183_- FIG00000433 26 5 27 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_230441_197_452_- FIG00136692 3 3 5 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_230445_1_452_+ FIG00000245 45 10 47 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_230515_1_452_- FIG00000087 27 5 30 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_230517_25_452_- FIG00000025 44 8 45 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_230519_1_452_- FIG00000659 126 18 126 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_230524_1_452_+ FIG00001550 34 6 35 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_230546_1_452_+ FIG00181043 114 17 115 Pullulanase (EC 3.2.1.41) Maltose and Maltodextrin Utilization 1.x T2D_unique_230548_13_452_- FIG00000388 24 10 26 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_230550_126_281_- FIG00000392 3 2 4 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_230571_76_452_- FIG00000741 20 6 21 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_unique_230593_1_452_+ FIG01959790 58 10 60 Periplasmic aromatic aldehyde oxidoreductase, FAD binding subunit YagS Purine Utilization 1 T2D_unique_230600_299_452_+ FIG00000624 17 4 18 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_230601_1_452_+ FIG00001548 45 11 46 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_230606_1_452_+ FIG00000187 75 15 76 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_230618_1_452_+ FIG00089870 122 18 122 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_unique_230631_1_452_+ FIG00004078 74 14 75 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_230646_1_397_+ FIG00005237 5 3 11 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_230677_52_452_- FIG00093180 14 6 15 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_230683_1_131_+ FIG00035175 6 2 7 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_230703_1_378_- FIG00000013 88 14 88 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_230734_1_452_- FIG00016514 11 5 13 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_230743_1_452_- FIG01260980 42 8 45 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_230758_1_201_+ FIG00023943 26 6 28 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_230758_256_452_- FIG00135315 34 7 35 Iojap protein Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_230784_1_452_+ FIG00000351 13 5 15 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_230801_1_452_- FIG00000578 42 9 43 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_230809_220_452_+ FIG01956356 16 6 17 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_230829_1_452_+ FIG00005797 86 14 87 Lipoteichoic acid synthase LtaS Type IIc Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_230838_265_452_- FIG00000402 4 2 6 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_230847_224_452_- FIG00000116 11 3 14 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_230901_1_257_+ FIG00000163 37 8 38 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_230916_1_330_+ FIG00001902 82 12 82 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_230917_221_452_+ FIG00010738 29 8 29 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_230925_1_452_+ FIG00000163 58 12 59 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_230928_1_452_+ FIG00000269 23 5 28 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_230977_43_452_+ FIG00126843 7 2 9 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_230994_27_452_- FIG00000022 18 4 19 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_unique_231013_1_452_+ FIG00000011 12 5 13 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_231035_200_451_- FIG00000494 11 3 13 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_231054_1_210_- FIG00000165 31 6 31 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_231061_1_451_+ FIG00018392 6 3 10 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_unique_231093_1_451_- FIG00003765 59 9 60 Low-affinity gluconate/H+ symporter GntU D-gluconate and ketogluconates metabolism 1.3 T2D_unique_231094_257_451_- FIG00003460 8 2 9 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_231102_1_271_- FIG00000430 24 5 25 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_unique_231113_1_159_+ FIG00004305 13 5 15 Outer membrane component of tripartite multidrug resistance system Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 1 T2D_unique_231121_1_451_- FIG00002541 17 6 30 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_231128_124_375_- FIG00008835 71 10 71 Programmed cell death antitoxin MazE MazEF toxin-antitoxing (programmed cell death) system 1 T2D_unique_231145_1_451_+ FIG00001437 21 6 23 Stringent starvation protein A Carbon Starvation 1.21 T2D_unique_231173_1_451_+ FIG00148704 119 18 120 tRNA-dependent lipid II--L-alanine ligase tRNA-dependent amino acid transfers 1 T2D_unique_231176_1_220_- FIG00006678 31 6 31 Nickel transport system permease protein NikC (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_231196_1_451_+ FIG00093180 10 5 11 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_231205_1_451_+ FIG00000147 37 9 38 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_231223_1_329_+ FIG00000641 6 3 7 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_231319_1_219_+ FIG00003520 59 8 59 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_231354_1_451_- FIG01007502 34 6 36 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_231373_1_242_- FIG00018699 8 2 10 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_231382_90_451_- FIG00057709 16 5 19 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_231396_1_451_- FIG00000121 10 3 15 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_231415_1_451_+ FIG00000402 42 9 44 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_231435_1_451_+ FIG00000402 112 18 112 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_231458_15_451_+ FIG00000413 48 10 50 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_231462_54_263_+ FIG00015729 22 4 24 LSU ribosomal protein L29p (L35e) Ribosome LSU bacterial 9 T2D_unique_231500_1_451_- FIG00005172 22 5 23 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_231513_1_451_- FIG00011468 3 2 4 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_231541_1_245_+ FIG00002968 8 2 9 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_231564_1_198_+ FIG01956356 25 5 27 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_231568_1_451_- FIG00004078 14 3 17 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_231588_1_451_- FIG00049433 22 7 24 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_231636_38_451_- FIG00007373 52 10 54 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_231649_1_451_- FIG00038343 5 3 6 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_231663_278_451_- FIG00002223 9 3 10 Flavodoxin 1 Flavodoxin 1 T2D_unique_231680_53_451_- FIG00001166 101 16 101 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_231687_1_451_- FIG00000147 121 18 121 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_231690_1_451_+ FIG00034293 72 11 73 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_231703_1_451_+ FIG00135554 25 8 26 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_231706_1_451_+ FIG00017454 27 7 29 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_231722_78_451_+ FIG00007957 4 3 6 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_231725_1_371_+ FIG00003555 4 3 6 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_231745_90_450_- FIG00047056 19 4 20 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_231755_1_450_- FIG00001656 30 8 32 RNA-binding protein Jag Cell Division Subsystem including YidCD 1 T2D_unique_231836_1_450_- FIG00018865 33 9 35 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_231854_213_450_+ FIG00000343 36 6 37 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_231881_1_450_- FIG00000224 3 5 19 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_231894_1_268_- FIG00029916 68 10 68 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_231921_1_371_- FIG01955899 91 14 91 Cellobiose phosphotransferase system YdjC-like protein Beta-Glucoside Metabolism 2.bc T2D_unique_231942_118_450_- FIG00016514 12 5 13 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_231944_1_415_+ FIG00000118 106 17 106 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_231966_1_450_+ FIG00002541 65 12 66 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_231975_1_450_+ FIG00005243 19 7 20 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_232014_1_450_- FIG00001643 32 9 33 Phosphoenolpyruvate carboxykinase [GTP] (EC 4.1.1.32) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_232025_1_450_+ 8 2 9 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_232029_1_450_+ FIG01260980 102 16 102 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_232054_35_450_- FIG00002416 16 5 17 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_232069_1_450_+ FIG00000402 18 7 20 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_232076_1_408_+ FIG00002265 13 4 15 Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE Maltose and Maltodextrin Utilization 1.x T2D_unique_232087_1_171_+ FIG00037273 35 6 35 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_unique_232090_1_450_+ FIG00005698 54 10 55 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_232098_1_450_+ FIG00002049 6 4 8 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_232101_86_450_+ FIG00000202 74 11 75 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_232139_1_450_- FIG00052943 110 17 111 Glycerol-3-phosphate transporter Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_232148_1_248_- FIG00000621 6 4 8 Iron-sulfur cluster regulator IscR Rrf2 family transcriptional regulators 4 T2D_unique_232153_1_192_+ FIG01304818 30 5 32 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_232163_223_450_- FIG00028694 23 5 24 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_232170_1_450_+ FIG00000245 46 12 47 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_232176_25_450_- FIG00000391 31 8 34 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_232205_1_450_- FIG00003506 52 11 53 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_232211_172_450_+ FIG00000212 25 6 26 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_232218_1_450_+ FIG01260980 8 3 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_232231_1_450_- FIG00067681 60 12 62 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_232259_1_450_+ FIG00054459 92 16 92 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_232270_1_450_- FIG00000979 4 2 6 Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) Cobalamin synthesis 2 T2D_unique_232279_1_450_- FIG00000777 32 8 35 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_232295_1_450_- FIG00010310 63 12 64 ATP-dependent DNA helicase pcrA (EC 3.6.1.-) CBSS-393121.3.peg.1913 1 T2D_unique_232342_1_450_- FIG00010771 17 7 23 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_232348_1_450_- FIG00001642 33 8 35 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_232350_1_450_+ FIG00000539 72 13 74 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_232362_1_251_- FIG00012746 52 9 52 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_232369_1_450_- FIG00000494 10 2 11 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_232387_1_420_+ FIG00026918 8 4 10 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_232417_255_450_+ FIG00598409 10 3 11 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_232428_128_450_+ FIG00008507 9 3 11 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_232445_223_450_+ FIG00066575 14 4 15 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_232458_1_450_+ FIG00000412 4 2 7 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_232473_1_450_- FIG01007502 67 14 68 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_232476_61_450_- FIG00003715 98 15 98 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_232494_48_449_+ FIG00001882 89 15 89 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_232508_1_449_- FIG00008490 15 3 17 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_232516_1_396_+ FIG00000325 25 7 27 COG0779: clustered with transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_232520_132_449_+ FIG00020897 5 4 6 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_232530_45_209_- FIG00136692 5 2 6 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_232538_1_449_+ FIG00000131 115 18 115 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_232542_1_449_- FIG00002857 49 11 50 Thiol peroxidase, Tpx-type (EC 1.11.1.15) Thioredoxin-disulfide reductase 2 T2D_unique_232560_1_449_- FIG00000636 70 13 71 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_232568_1_449_- FIG00130344 18 5 20 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_232597_162_449_+ FIG00009156 74 10 74 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_232603_1_449_+ FIG00000834 5 4 6 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_232605_1_449_+ FIG00008490 116 17 116 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_232640_1_449_+ FIG00054459 14 6 16 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_232646_36_449_- FIG00010675 5 2 7 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_unique_232661_1_205_+ FIG00002560 35 7 40 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_232661_216_449_+ FIG00005329 50 9 50 V-type ATP synthase subunit F (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_232687_1_320_- FIG00016555 21 7 22 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_232689_1_449_- FIG00007079 32 6 35 FIG007079: UPF0348 protein family CBSS-269801.1.peg.1715 1 T2D_unique_232741_1_449_- FIG00031723 8 2 9 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_unique_232748_1_423_+ FIG01304886 9 4 11 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_unique_232759_1_199_- FIG01260980 8 2 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_232822_1_299_+ FIG00020613 4 2 5 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_232830_1_449_+ FIG00001932 80 13 81 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_232849_1_449_+ FIG00000117 20 3 23 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_232855_1_449_- FIG01260980 29 8 30 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_232856_1_449_+ FIG00018396 117 17 117 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_232882_1_260_+ FIG00016110 42 8 43 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_232893_1_449_- FIG00001469 5 4 6 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_232895_1_449_- FIG00016663 104 15 104 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_232910_1_319_- FIG00086220 4 3 6 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_232958_1_155_- FIG00065780 7 2 9 Endo-1,4-beta-mannosidase Mannose Metabolism 2.0 T2D_unique_232970_1_449_- FIG00001548 17 6 20 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_232982_1_449_- FIG00022899 99 17 99 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_232986_1_449_- FIG00134830 45 10 46 Lysine 2,3-aminomutase (EC 5.4.3.2) Lysine degradation 1.0 T2D_unique_233011_1_449_+ FIG00000390 23 4 25 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_233035_212_449_- FIG00000659 43 8 46 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_233064_1_449_+ FIG00003387 74 14 75 ABC transporter multidrug efflux pump, fused ATP-binding domains ATP-dependent efflux pump transporter Ybh 1 T2D_unique_233066_1_209_- FIG00007957 13 5 28 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_233098_1_449_+ FIG00041382 32 6 33 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_233100_1_449_+ FIG00001732 14 3 15 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_233103_1_449_+ FIG00001088 12 4 14 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_233109_1_449_+ FIG00002311 117 17 118 Septation ring formation regulator EzrA CBSS-393130.3.peg.794 2 T2D_unique_233110_1_449_- FIG00138754 28 7 29 Uncharacterized protein YtfN Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_233151_1_449_- FIG00000863 123 17 123 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_233160_1_449_+ FIG00000173 62 12 63 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_233174_1_449_+ FIG00001824 15 5 19 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_233176_1_289_+ FIG00142848 59 10 59 Shikimate 5-dehydrogenase I gamma (EC 1.1.1.25) Chorismate Synthesis 1 T2D_unique_233186_1_354_+ FIG00000329 72 12 74 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_233194_1_449_- FIG00000402 5 4 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_233197_1_409_+ FIG00041038 19 6 20 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_233200_1_449_+ FIG00000269 61 11 62 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_233219_1_448_+ FIG00003433 4 2 5 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_233247_1_366_- FIG00007157 4 2 7 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_233252_1_449_+ FIG01291525 83 15 84 Fibronectin-binding protein Streptococcus pyogenes recombinatorial zone 8 T2D_unique_233292_132_449_- FIG00002161 58 11 59 MotA/TolQ/ExbB proton channel family protein Ton and Tol transport systems 2 T2D_unique_233327_1_214_- FIG00000116 9 2 10 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_233347_1_448_+ FIG00135546 46 8 47 Predicted rhamnogalacturonan lyase in rhamnose utilization cluster L-rhamnose utilization 1 T2D_unique_233352_1_223_- FIG00000187 28 5 29 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_233363_1_448_- FIG00018699 12 4 14 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_233374_26_280_- FIG00000840 5 3 7 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_233403_173_448_+ FIG00000040 24 4 25 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_233409_1_265_+ FIG00000372 17 4 18 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_233416_1_325_- FIG00001065 6 4 7 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_233428_1_448_+ FIG01304636 3 2 4 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_233431_1_192_+ FIG00000351 5 4 6 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_233440_1_448_+ FIG00000402 17 7 18 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_233444_162_448_+ FIG00117785 25 5 26 Guanine deaminase (EC 3.5.4.3) Purine Utilization 1 T2D_unique_233488_1_387_+ FIG00013638 6 2 7 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_233494_234_448_+ FIG00000601 54 8 54 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_233503_1_448_+ FIG00001818 113 17 114 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_233523_1_341_- FIG00001882 76 11 76 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_233565_1_448_+ FIG00002020 124 18 125 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_233570_56_448_- FIG00003596 68 11 69 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_233587_1_448_+ FIG00003406 30 9 32 AmpG permease Recycling of Peptidoglycan Amino Acids 1 T2D_unique_233595_1_448_- FIG00001469 21 6 23 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_233605_76_448_+ FIG00000812 16 5 17 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_233613_1_448_- FIG00001647 22 6 25 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_233619_1_448_- FIG01304329 46 10 50 Chromosome (plasmid) partitioning protein ParA Cell Division Subsystem including YidCD 1 T2D_unique_233627_17_331_+ FIG00000450 74 11 75 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_233675_1_448_+ FIG00001104 98 16 100 Arginine deiminase (EC 3.5.3.6) Arginine and Ornithine Degradation 1.34 T2D_unique_233680_1_448_+ FIG00001469 4 3 5 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_233681_1_448_+ FIG00000268 69 14 70 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_233685_1_250_+ FIG00000148 13 4 15 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_233707_1_335_+ FIG00000390 9 3 11 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_233712_1_448_- FIG00000317 8 3 10 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_233717_205_448_+ FIG00000206 45 7 46 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_233726_1_448_+ FIG01260980 61 10 62 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_233731_65_448_- FIG00000241 30 8 32 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_233756_1_448_+ FIG00007025 4 3 7 Multiple sugar ABC transporter, ATP-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_233818_1_193_- FIG00006868 18 4 19 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_233841_190_448_+ FIG00009265 54 9 55 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) Selenocysteine metabolism 1.1 T2D_unique_233851_1_448_- FIG00000659 46 11 48 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_233863_88_448_- FIG00003433 85 13 85 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_233881_1_448_- FIG00001294 3 2 5 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_unique_233917_167_448_- FIG00001401 5 3 6 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_233934_1_448_+ FIG00001548 94 15 95 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_233966_1_448_- FIG00018369 115 18 115 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_233972_1_448_- FIG00000822 99 16 99 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_233990_1_448_- FIG00086220 5 4 6 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_234050_1_159_- FIG00000085 38 6 38 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_234051_1_202_+ FIG00000141 26 6 27 LSU ribosomal protein L7/L12 (P1/P2) Ribosome LSU bacterial 9 T2D_unique_234053_1_289_- FIG00038920 9 3 10 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_234054_98_448_- FIG00005172 18 5 20 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_234064_1_299_+ FIG00001469 40 8 42 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_234068_1_448_- FIG00000402 24 9 25 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_234087_1_448_- FIG00043547 94 14 95 Lipoteichoic acid synthase LtaS Type IIa Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_234107_1_228_+ FIG00001294 48 8 49 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_unique_234197_1_447_+ FIG00138182 40 8 42 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_234207_261_447_- FIG00000032 44 7 44 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_234210_1_447_- FIG00138258 57 13 58 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_234216_289_447_+ FIG00028694 5 2 6 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_234227_278_447_+ FIG00020613 35 6 35 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_234231_27_447_+ FIG00004099 96 14 96 Regulatory protein RecX RecA and RecX 1 T2D_unique_234257_297_447_+ FIG00034973 18 3 19 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_unique_234263_1_447_- FIG00000070 10 6 15 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_234270_1_447_+ FIG00004078 108 16 109 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_234322_1_447_+ FIG00012945 92 15 93 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_234332_1_447_- FIG00000636 84 14 85 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_234334_1_447_- FIG00002194 120 17 120 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_234369_1_447_+ FIG01260980 42 9 43 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_234378_1_447_+ FIG00000402 25 6 27 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_234410_1_447_+ FIG00016663 3 2 5 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_234417_217_447_- FIG00004589 38 7 38 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_234465_1_379_- FIG00003086 65 11 66 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_234467_172_447_+ FIG00000277 21 6 23 Adenine phosphoribosyltransferase (EC 2.4.2.7) Stringent Response, (p)ppGpp metabolism 1 T2D_unique_234487_1_447_- FIG00000494 29 9 31 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_234493_1_447_+ FIG00000402 8 4 10 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_234494_1_338_+ FIG00001347 7 4 10 Chitinase (EC 3.2.1.14) Chitin and N-acetylglucosamine utilization 2 T2D_unique_234503_1_447_- FIG00024073 7 4 9 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_234521_1_140_- FIG00051439 4 2 5 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_234525_42_410_+ FIG00002153 98 14 98 Putative regulator of the mannose operon, ManO Mannose Metabolism 2.0 T2D_unique_234528_1_243_+ FIG00067300 6 2 7 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_234530_1_447_+ FIG00000315 18 5 19 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_234533_1_447_+ FIG00001548 37 7 38 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_234576_1_447_- FIG00000156 4 4 12 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_234601_1_447_- FIG00015338 7 4 9 D-beta-hydroxybutyrate permease Polyhydroxybutyrate metabolism 5.6 T2D_unique_234602_89_447_- FIG00013638 30 7 31 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_234608_1_447_+ FIG00001469 20 6 22 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_234612_1_447_- FIG00014990 85 13 86 Similar to ribosomal large subunit pseudouridine synthase D, Bacillus subtilis YjbO type CBSS-222523.1.peg.1311 1 T2D_unique_234614_1_447_- FIG00024930 35 8 36 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_234649_1_447_- FIG00077620 30 7 32 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_234657_1_240_- FIG00000402 15 4 18 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_234665_154_447_- FIG00000402 65 11 67 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_234669_1_447_+ FIG00080955 80 13 81 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_234670_1_447_+ FIG00475203 93 14 94 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_234680_82_447_+ FIG00002560 19 5 20 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_234691_1_241_- FIG00000659 13 4 14 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_234716_1_382_- FIG00001882 3 3 5 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_234731_1_447_+ FIG00000146 62 11 63 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_234776_1_447_+ FIG00000333 72 15 73 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_234780_53_447_+ FIG00001548 29 8 31 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_234789_1_447_+ FIG00000256 16 4 18 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_234796_76_393_+ FIG00001561 61 10 62 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_234806_1_447_+ FIG00000494 22 5 23 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_234828_1_300_+ FIG00010844 84 11 85 Flavodoxin Flavodoxin 1 T2D_unique_234833_1_447_- FIG01261528 25 5 26 Na+/H+ antiporter NhaD type Na(+) H(+) antiporter 1 T2D_unique_234854_1_447_- FIG00055715 54 12 56 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_234858_1_447_- FIG00134135 54 11 55 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_234879_1_447_+ FIG00008556 29 6 30 L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_234885_1_286_- FIG00006032 15 5 17 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_234900_1_447_+ FIG00138258 121 17 121 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_234935_1_446_- FIG00000185 128 17 128 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_234938_1_446_- FIG00041038 46 9 47 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_234948_1_446_+ FIG00000442 7 3 10 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_234950_1_446_+ FIG01307086 13 5 14 [FeFe]-hydrogenase maturation GTPase HydF FeFe hydrogenase maturation 1 T2D_unique_234974_1_446_- FIG00000402 73 14 73 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_234975_1_446_- FIG00000838 9 6 11 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_235001_1_311_+ FIG00000131 19 5 21 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_235002_1_446_- FIG00018699 121 17 121 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_235011_1_142_- FIG00010600 17 5 18 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_235030_1_446_+ FIG00000175 31 8 32 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_235037_188_446_+ FIG00000892 14 5 15 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (EC 3.6.1.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_235066_1_446_- FIG00005797 109 15 110 Lipoteichoic acid synthase LtaS Type IIc Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_235072_1_446_- FIG00003472 69 12 71 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_235128_172_446_- FIG00003174 7 3 9 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_235130_1_446_+ FIG00003410 114 17 114 Tagatose-6-phosphate kinase AgaZ (EC 2.7.1.144) N-Acetyl-Galactosamine and Galactosamine Utilization B.x T2D_unique_235136_1_446_+ FIG00000280 67 15 70 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_235151_1_446_+ FIG00035175 46 10 47 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_235166_1_446_+ FIG00000338 33 9 34 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_235167_1_446_+ FIG00016514 41 7 43 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_235168_1_446_+ FIG00000645 3 2 4 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_235179_1_418_+ FIG01304886 31 6 32 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_unique_235234_1_301_- FIG00846773 79 12 79 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_235239_1_446_+ FIG00000421 31 9 59 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_235248_1_446_+ FIG00041382 119 17 119 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_235282_31_446_+ FIG00000182 79 14 80 LSU ribosomal protein L11p (L12e) Ribosome LSU bacterial 9 T2D_unique_235293_1_446_+ FIG00451095 106 16 106 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_235298_1_446_+ FIG00000420 45 11 48 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_235331_1_290_+ FIG00031969 23 5 24 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_235339_1_446_+ FIG00024073 13 4 15 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_235341_1_446_+ FIG00001406 78 12 79 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_235358_1_446_- FIG00001882 104 16 104 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_235362_1_446_- FIG00000176 25 5 26 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_235392_1_194_- FIG01290653 25 4 25 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_235410_12_446_- FIG00001384 110 16 112 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_235416_1_250_- FIG00004229 40 7 41 Heptaprenyl diphosphate synthase component I (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_235417_1_446_+ FIG00016514 100 15 101 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_235430_1_446_+ FIG00000308 21 7 23 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_235439_1_446_+ FIG00000527 5 3 6 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_235456_1_360_+ FIG00846773 28 5 30 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_235458_1_306_+ FIG00073301 17 4 18 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_235470_1_323_- FIG00008490 67 10 68 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_235498_1_446_- FIG01260980 14 5 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_235500_1_207_+ FIG00001548 11 2 12 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_235544_1_446_- FIG00041038 20 6 22 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_235550_1_446_+ FIG00030688 67 11 68 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_235580_1_238_- FIG00001384 57 8 57 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_235585_1_446_- FIG00000838 28 8 29 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_235590_12_368_+ FIG00000200 55 10 56 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_unique_235606_1_446_- FIG00006691 87 14 89 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_235609_1_446_- FIG01583289 15 5 17 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_235618_1_240_+ FIG00000151 50 9 50 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_235635_1_317_+ FIG00006953 52 7 53 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_unique_235636_79_446_+ FIG00085033 4 3 6 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_235648_104_446_- FIG01955850 4 2 11 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_235658_56_446_- FIG00083946 52 9 53 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_235669_1_446_- FIG00001712 34 8 36 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_235678_1_446_+ FIG00000343 74 11 77 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_235724_252_446_- FIG00002300 3 2 4 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_235736_48_386_+ FIG00002974 52 9 54 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_235746_151_445_- FIG00138258 22 6 24 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_235747_1_445_- FIG00002020 50 10 52 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_235752_1_310_- FIG00058830 31 6 33 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_235762_1_445_+ FIG00000372 7 3 8 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_235769_16_445_+ FIG00001269 3 2 5 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_235792_1_185_- FIG00005992 21 5 22 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_235806_1_445_+ FIG00121768 115 17 115 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_235818_1_445_- FIG00018536 15 7 17 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_235829_1_294_- FIG00005329 75 11 75 V-type ATP synthase subunit F (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_235835_311_445_- FIG00000397 17 4 18 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_235840_1_445_+ FIG00003086 11 2 14 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_235849_1_445_- FIG00001088 30 8 34 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_235852_1_445_- FIG00002470 46 10 47 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_235856_1_445_- FIG00000001 7 3 10 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_235866_1_193_- FIG00000832 51 7 51 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_unique_235909_1_445_+ FIG00006151 62 13 62 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_235926_1_445_- FIG00130339 28 8 29 Cytochrome c heme lyase subunit CcmF Copper homeostasis 12 T2D_unique_235930_1_445_- FIG00028203 36 10 38 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_235938_1_445_- FIG00000208 10 3 12 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_235960_1_361_+ FIG00000387 23 5 25 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_235977_1_445_+ FIG00007147 126 18 126 Glycosyltransferase LafB, responsible for the formation of Gal-Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_235998_1_296_- FIG00000040 17 4 18 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_236007_1_445_- FIG00000990 6 3 11 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_236022_1_445_+ FIG00004037 13 6 15 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_236027_1_445_+ FIG00001548 60 13 61 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_236035_1_445_- FIG00001547 17 4 18 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_236049_1_445_+ FIG00021517 114 16 114 Cell division protein FtsQ Cell Division Cluster 1.x T2D_unique_236096_1_445_+ FIG00000441 17 3 18 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_236109_1_445_+ FIG00001750 37 10 38 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_236129_1_445_- FIG00000317 101 16 101 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_236131_1_445_- FIG01260980 30 9 32 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_236168_152_445_- FIG00019508 4 3 5 Phage major tail protein Phage tail proteins 2 4 T2D_unique_236184_287_445_+ FIG00846773 26 5 27 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_236187_1_445_- FIG00004037 16 4 17 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_236198_307_445_+ FIG00000084 17 4 19 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_236224_1_445_+ FIG00000372 39 9 41 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_236238_161_445_+ FIG00000070 29 7 30 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_236252_1_445_+ FIG00002265 47 9 49 Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE Maltose and Maltodextrin Utilization 1.x T2D_unique_236268_237_445_+ FIG00000283 22 4 23 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_236270_1_445_+ FIG00135554 15 4 16 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_236290_102_445_+ FIG00000402 40 9 41 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_236295_24_445_+ FIG00000456 22 7 24 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_236310_1_298_- FIG00048580 5 2 7 Hcp transcriptional regulator HcpR (Crp/Fnr family) Nitrosative stress 4 T2D_unique_236329_297_445_- FIG00000047 4 2 5 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_236335_1_445_+ FIG00000140 21 8 23 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_236343_1_445_- FIG00041038 5 3 7 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_236358_1_363_+ FIG00067248 49 10 52 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_236367_1_445_- FIG00007059 32 9 34 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_236368_1_445_+ FIG00001358 27 7 30 Error-prone, lesion bypass DNA polymerase V (UmuC) DNA repair, bacterial UmuCD system 3 T2D_unique_236412_1_445_+ FIG00066504 8 2 9 Glucarate dehydratase (EC 4.2.1.40) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_236435_1_157_- FIG00229257 3 2 4 Histidinol-phosphatase (EC 3.1.3.15) Histidine Biosynthesis 1 T2D_unique_236443_1_163_+ FIG00002839 27 4 27 MutS-related protein, family 1 DNA repair, bacterial MutL-MutS system 1 T2D_unique_236456_1_445_+ FIG00000118 43 10 45 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_236462_1_153_+ FIG00000146 3 3 4 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_236484_44_445_- FIG00006032 104 16 104 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_236491_1_445_+ FIG01260980 23 8 24 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_236562_1_444_- FIG00001025 40 9 42 Urease accessory protein UreF Urease subunits 1.x T2D_unique_236580_1_333_- FIG00006032 53 9 55 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_236582_1_444_- FIG00030688 11 4 12 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_236597_117_444_- FIG00000151 19 5 20 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_236599_1_376_- FIG00001548 56 10 57 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_236603_1_264_+ FIG00000367 4 3 7 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_236621_1_444_+ FIG00000156 101 17 101 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_236641_1_444_- FIG00001647 8 3 9 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_236644_1_444_+ FIG01260980 47 10 48 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_236647_222_444_- FIG00055520 3 2 4 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_236693_85_357_- FIG00000070 61 9 62 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_236696_1_444_+ FIG00008507 16 3 17 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_236697_1_277_- FIG00001667 5 2 6 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_236704_1_444_- FIG00002049 5 4 8 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_236712_71_444_+ FIG00046929 30 7 31 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_236748_1_314_+ FIG00019251 19 4 20 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_236800_1_444_- FIG00000185 36 6 39 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_236802_1_444_- FIG00007328 29 7 30 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_236838_1_176_- FIG00000583 8 2 9 RNA-binding protein Hfq Hfl operon 1.111 T2D_unique_236839_1_444_- FIG01260980 29 6 30 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_236849_187_444_+ FIG00000075 8 2 11 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_236875_1_444_+ FIG00000308 65 10 68 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_236888_295_444_+ FIG00000812 13 3 14 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_236907_1_444_- FIG00002761 10 4 11 DedA protein Uptake of selenate and selenite 1.1 T2D_unique_236914_1_444_+ FIG00000176 40 8 41 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_236931_1_386_+ FIG00013638 21 7 25 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_236971_1_444_+ FIG00000402 15 6 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_236983_1_234_- FIG00007960 38 8 40 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_236983_258_444_- FIG00003580 35 6 36 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_236987_1_444_- FIG00000289 14 5 15 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_236988_1_444_+ FIG00009194 114 17 115 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_236989_1_444_+ FIG00000343 41 11 42 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_237008_1_321_+ FIG00000392 82 13 82 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_237010_1_444_+ FIG00000165 63 12 64 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_237014_1_444_- FIG00058998 23 6 24 Vancomycin response regulator VanR Resistance to Vancomycin X T2D_unique_237023_113_444_+ FIG00007941 13 5 17 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_237024_1_444_- FIG00000080 50 11 51 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_237029_1_444_- FIG00003704 3 3 4 Xanthine-guanine phosphoribosyltransferase (EC 2.4.2.22) Purine conversions 4.1118100 T2D_unique_237048_1_444_- FIG00719736 21 4 24 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_237083_1_444_- FIG00475203 7 2 8 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_237139_1_444_- FIG00001550 44 8 45 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_237173_1_444_- FIG00020185 8 4 10 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_237184_275_444_- FIG00000040 17 4 17 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_237185_1_444_+ FIG00000175 37 10 38 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_237214_1_444_- FIG00051882 36 9 39 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Cobalamin synthesis 2 T2D_unique_237225_1_444_+ FIG00000539 78 14 79 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_237237_265_444_+ FIG00000401 10 3 11 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_237265_112_444_+ FIG01031896 11 5 13 Anti-sigma F factor (EC 2.7.11.1) SigmaB stress responce regulation 4.?x T2D_unique_237284_1_444_+ FIG00030191 113 17 113 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_237301_258_444_+ FIG00009229 6 2 8 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_237312_1_444_- FIG00000080 21 10 23 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_237314_1_201_- FIG01260980 4 3 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_237336_1_444_- FIG00016286 4 3 7 Ribosyl nicotinamide transporter, PnuC-like Cobalt-zinc-cadmium resistance 1.26 T2D_unique_237396_1_312_+ FIG00000985 9 4 10 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_237410_1_227_- FIG00011236 53 8 53 Phosphomevalonate kinase (EC 2.7.4.2) Isoprenoid Biosynthesis 2.x T2D_unique_237410_229_443_- FIG00001783 45 7 45 Diphosphomevalonate decarboxylase (EC 4.1.1.33) Isoprenoid Biosynthesis 2.x T2D_unique_237414_1_443_+ FIG00000477 122 17 122 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_237434_1_443_+ FIG01954244 4 2 6 putative polysialic acid transport protein Rhamnose containing glycans 4.1 T2D_unique_237458_300_443_- FIG00022300 17 3 18 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_237465_1_443_+ FIG00034293 119 17 119 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_237479_1_443_+ FIG00007495 20 6 22 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_237491_1_443_+ FIG00000047 49 11 50 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_237497_63_287_+ FIG00003435 23 4 24 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_237511_1_443_- FIG00012067 111 17 111 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_237529_1_443_+ FIG01304636 3 4 5 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_237531_1_443_+ FIG00001803 13 4 14 Polyferredoxin NapH (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_237582_19_443_- FIG00000439 5 3 6 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_237625_1_389_- FIG00000477 10 6 15 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_237646_1_443_+ FIG00018369 11 4 12 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_237650_1_443_- FIG00005283 46 9 47 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_237657_1_443_- FIG00000777 27 6 28 NADP-dependent malic enzyme (EC 1.1.1.40) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_237666_1_268_+ FIG00001505 9 3 10 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_237671_1_196_+ FIG00011468 22 5 23 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_237676_1_443_- FIG00051439 7 2 8 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_237683_19_443_+ FIG00001530 16 6 18 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_237715_1_443_+ FIG00007157 75 12 76 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_237741_1_443_+ FIG00000877 6 2 7 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_237744_1_443_+ FIG00010454 19 6 22 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_237752_1_443_- FIG00000573 10 4 11 3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_unique_237768_1_230_- FIG00136692 43 7 44 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_237771_133_443_- FIG00000047 68 10 68 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_237786_7_443_- FIG00052300 12 5 13 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_237801_1_443_- FIG00000422 97 15 97 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_237841_1_443_+ FIG00000145 38 9 40 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_237847_1_443_+ FIG00138468 47 8 48 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_237855_1_443_- FIG00000147 78 12 79 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_237881_1_443_+ FIG00035634 17 4 18 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_237882_1_146_- FIG00000402 6 2 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_237892_1_443_+ FIG00000146 69 14 70 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_237896_1_363_+ FIG00000241 14 4 15 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_237899_127_443_- FIG00598409 81 12 81 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_237908_1_443_+ FIG00001712 35 9 36 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_237932_1_443_+ FIG00055134 5 2 7 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily M (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_237943_1_188_- FIG00018396 13 3 14 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_237952_1_443_+ FIG00003174 18 4 21 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_237961_76_261_- FIG00006632 11 3 12 LSU ribosomal protein L32p Ribosome LSU bacterial 9 T2D_unique_237973_227_443_- FIG00001054 14 4 16 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_237992_1_443_+ FIG01955967 19 3 21 L-alanine-DL-glutamate epimerase Muconate lactonizing enzyme family 1 T2D_unique_237997_1_386_+ FIG00039969 98 15 98 CRISPR-associated protein, Csm5 family CRISPR-associated cluster 1 T2D_unique_238031_97_443_+ FIG00085033 66 11 66 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_238036_1_443_+ FIG00136036 77 14 97 Betaine reductase component B alpha subunit (EC 1.21.4.4) Glycine reductase, sarcosine reductase and betaine reductase 4 T2D_unique_238049_1_345_- FIG00008941 27 5 29 Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_238054_159_428_+ FIG00000207 5 2 6 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_238056_238_443_- FIG00000241 58 8 58 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_238059_1_443_+ FIG00037240 4 3 5 Alpha-N-arabinofuranosidase 2 (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_238063_1_191_- FIG00000296 16 3 17 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_unique_238063_213_443_- FIG00138538 15 4 16 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_238076_86_443_- FIG00002803 9 5 10 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_238078_1_443_- FIG00003251 103 16 103 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_238081_1_216_+ FIG00000166 23 6 24 LSU ribosomal protein L15p (L27Ae) Ribosome LSU bacterial 9 T2D_unique_238101_1_443_- FIG00028203 29 8 30 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_238102_1_443_- FIG00000866 21 7 24 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_238120_160_438_+ FIG00139238 22 4 26 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_238127_1_328_+ FIG00005860 13 4 14 SusD, outer membrane protein Cellulosome 1.x T2D_unique_238137_1_328_- FIG00052802 7 2 8 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_unique_238142_1_442_+ FIG01304636 86 15 102 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_238170_1_442_- FIG00000990 37 10 39 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_238177_1_442_+ FIG00000139 126 17 126 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_238189_1_442_- FIG00016888 21 6 22 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_238196_1_442_+ FIG01007502 4 2 6 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_238209_1_442_+ FIG00011468 9 3 11 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_238220_103_442_- FIG00000401 18 4 19 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_238228_174_442_+ FIG00001732 8 2 9 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_238231_1_442_+ FIG00000463 46 12 48 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_238233_1_442_+ FIG00000414 35 9 36 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_238247_1_243_+ FIG00000235 5 4 9 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_238259_1_442_+ FIG00058830 67 12 69 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_238268_1_442_- FIG00021289 37 9 39 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_238279_240_442_- FIG00139238 11 3 12 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_238320_1_442_+ FIG00000683 121 17 121 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) Methionine Biosynthesis 8 T2D_unique_238325_1_323_- FIG00001550 12 5 14 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_238328_1_442_- FIG00006997 10 3 11 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_238335_1_442_- FIG00000116 14 4 16 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_238350_1_442_+ FIG00018369 40 7 41 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_238377_160_442_+ FIG00000402 19 6 20 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_238393_1_442_+ FIG00945384 10 5 13 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_238408_1_442_+ FIG00000039 80 14 80 Translation elongation factor Tu Translation elongation factors bacterial 1.1 T2D_unique_238422_1_442_+ 5 6 11 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_238428_1_442_- FIG00000738 106 17 107 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_238431_20_442_- FIG00001029 108 15 109 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_238432_1_350_+ FIG00000111 74 12 75 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_238439_1_442_- FIG00038343 14 4 15 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_238462_275_442_- FIG00000812 34 5 35 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_238496_1_442_+ FIG00000383 9 6 11 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_238500_1_442_+ FIG00000442 4 2 6 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_238529_1_442_- FIG00001798 70 12 80 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_238537_1_129_+ FIG00047509 6 2 7 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_238543_1_442_+ FIG00006463 13 5 15 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_238557_1_442_+ FIG00038343 23 4 25 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_238563_1_442_+ FIG00135056 125 17 126 Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2) Anaerobic respiratory reductases 3 T2D_unique_238579_1_442_- FIG00675645 112 17 112 Acetaldehyde dehydrogenase, ethanolamine utilization cluster Fermentations: Mixed acid 1 T2D_unique_238582_1_442_+ FIG00002034 7 2 9 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_238587_288_442_- FIG00001203 5 2 6 Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit (EC 2.4.2.-) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_238602_315_442_+ FIG00018561 21 4 22 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_238620_1_408_+ FIG00000276 48 9 49 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_unique_238628_182_442_- FIG00763261 5 3 7 DNA replication protein DnaC DNA-replication 4 T2D_unique_238630_30_442_+ FIG00133325 13 3 15 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_238632_187_442_- FIG00000279 27 7 29 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_238656_1_263_+ FIG00000338 7 2 9 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_238658_312_442_+ FIG00020613 19 4 20 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_238680_125_442_- FIG00000211 22 5 23 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_238713_1_432_- FIG00000441 108 16 109 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_238737_1_442_- FIG00000465 6 3 9 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_238745_49_442_+ FIG00146516 19 5 21 Similar to Hydroxyacylglutathione hydrolase, but in an organism lacking glutathione biosynthesis Glutathione: Non-redox reactions 9 T2D_unique_238806_69_442_+ FIG01955809 21 6 23 Cytoplasmic copper homeostasis protein cutC Copper homeostasis: copper tolerance 3 T2D_unique_238811_1_394_- FIG00005283 41 9 43 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_238848_1_442_+ FIG00048839 78 15 79 Alpha-N-acetylglucosaminidase (EC 3.2.1.50) Chitin and N-acetylglucosamine utilization 2 T2D_unique_238853_1_328_- FIG00002354 37 8 38 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_238862_62_442_- FIG00002380 36 10 38 anti-sigma B factor RsbT SigmaB stress responce regulation 4.?x T2D_unique_238880_1_442_- FIG00000309 8 3 10 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_238886_1_150_+ FIG00000258 7 2 8 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_238899_1_442_+ FIG00022300 114 16 114 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_238902_1_442_- FIG00001469 8 3 9 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_238917_1_442_+ FIG00000793 79 13 80 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_238943_1_442_+ FIG00002416 20 5 21 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_238960_169_442_- FIG00003251 7 4 10 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_238973_1_441_- FIG00000312 3 3 5 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_238978_1_441_+ FIG00018369 53 11 55 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_239017_125_441_- FIG00051882 18 7 20 Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) Cobalamin synthesis 2 T2D_unique_239034_1_441_+ FIG00000165 72 14 74 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_239052_1_441_+ FIG00000243 17 3 19 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_239053_1_441_- FIG00080955 12 3 13 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_239073_1_441_- FIG00001088 88 14 88 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_239081_1_441_- FIG00000494 4 3 7 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_239085_1_441_- FIG00000552 127 18 127 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_239093_1_441_- FIG00001548 28 6 30 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_239117_49_441_- FIG00000732 47 10 50 Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11) Putative sugar ABC transporter (ytf cluster) 3.0 T2D_unique_239136_98_328_+ FIG00000636 27 6 28 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_239168_1_441_+ FIG00010285 29 7 35 Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_239177_130_441_+ FIG00003175 23 6 24 Pyruvate:ferredoxin oxidoreductase, beta subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_239229_1_441_+ FIG00945384 92 17 92 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_239246_1_441_- FIG00475203 8 2 9 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_239275_1_441_- FIG00000242 123 18 123 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_239306_1_345_+ FIG00000695 79 12 79 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_239335_1_441_+ FIG00005172 48 11 49 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_239339_1_441_+ FIG00002110 92 15 94 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_239344_1_441_+ FIG00000672 12 5 13 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_239367_26_441_- FIG00000267 100 16 100 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_239373_1_441_- FIG00028694 36 9 50 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_239383_1_441_- FIG00004788 114 17 114 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_239389_1_441_+ FIG00000084 50 10 51 Ornithine carbamoyltransferase (EC 2.1.3.3) Arginine Biosynthesis extended 1.0 T2D_unique_239396_1_233_- FIG00028461 10 3 11 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_239400_81_441_- FIG00000317 21 4 22 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_239409_1_224_- FIG00015082 9 3 11 Prevent host death protein, Phd antitoxin Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_239499_122_340_- FIG00000092 6 3 7 LSU ribosomal protein L31p Ribosome LSU bacterial 9 T2D_unique_239504_1_441_- FIG00019251 25 5 26 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_239508_17_441_+ FIG00000522 24 5 27 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_239513_1_441_+ FIG00000165 21 5 23 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_239527_1_441_+ FIG00004568 34 8 35 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Alkanesulfonate assimilation 9.? T2D_unique_239541_1_441_- FIG00048014 27 7 30 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_239550_137_441_+ FIG00000128 12 6 13 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_239552_1_178_+ FIG00001687 46 7 46 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_239563_1_441_+ FIG00000241 12 3 14 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_239583_1_357_- FIG00023946 3 2 5 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_239585_1_441_+ FIG00003506 21 8 24 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_239593_1_441_- FIG00135469 11 4 13 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_239616_1_441_+ FIG00000782 49 9 51 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_239623_1_441_- FIG00000962 110 17 110 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_239626_1_441_+ FIG00052730 27 8 28 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_239634_1_441_+ FIG00007957 57 9 59 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_239658_235_441_+ FIG00120441 33 5 34 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_239715_1_159_+ FIG00000404 32 6 33 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_239718_58_441_- FIG00002968 7 2 8 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_239728_1_441_- FIG00000336 42 10 43 Cytosol aminopeptidase PepA (EC 3.4.11.1) EC 3.4.11.- Aminopeptidases 1 T2D_unique_239737_1_441_+ FIG00037431 55 10 56 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_239739_118_440_- FIG00000578 6 2 8 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_239749_1_440_+ FIG00010262 11 3 12 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) EC699-706 1 T2D_unique_239777_133_440_+ FIG00044622 44 8 45 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_239836_1_144_- FIG00002560 30 5 30 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_239854_1_440_+ FIG00000032 122 17 122 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_239857_1_440_- FIG00052605 122 17 122 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_239896_144_440_- FIG00028694 14 5 15 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_239900_1_143_+ FIG00000368 4 2 5 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_239900_151_440_+ FIG00001932 50 8 51 Probable Co/Zn/Cd efflux system membrane fusion protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_239902_1_440_- FIG00000343 52 9 53 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_239925_1_440_+ FIG00024930 71 12 72 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_239929_1_440_+ FIG00051439 74 13 76 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_239949_46_440_- FIG00012945 83 12 83 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_239960_1_440_- FIG00000168 11 3 13 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_239977_227_440_- FIG00022300 37 6 38 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_239982_1_440_+ FIG01260980 9 5 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_239990_1_440_+ FIG00007941 20 7 22 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_239993_1_440_- FIG00014000 8 3 13 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_240017_1_440_- FIG00000287 32 6 34 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_240023_8_440_- FIG00132630 25 9 26 Ferric uptake regulation protein FUR Oxidative stress 1.2 T2D_unique_240031_1_440_- FIG00899307 62 14 64 Monofunctional biosynthetic peptidoglycan transglycosylase (EC 2.4.2.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_240098_102_440_+ FIG00000341 47 8 48 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_240110_1_374_- FIG00016555 25 4 26 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_240124_1_440_+ FIG01303740 11 4 12 Signal peptidase SipW (EC 3.4.21.89), required for TasA secretion CBSS-176299.4.peg.1292 3 T2D_unique_240152_1_440_- FIG00001358 114 17 114 Error-prone, lesion bypass DNA polymerase V (UmuC) DNA repair, bacterial UmuCD system 3 T2D_unique_240153_1_440_- FIG00000038 35 9 36 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_240155_1_440_- FIG00064110 85 14 85 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_240180_1_440_- FIG00229199 6 4 8 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_240191_1_440_- FIG00001469 20 5 22 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_240209_1_165_- FIG00018699 7 3 8 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_240212_1_440_- FIG00047414 15 4 17 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_240216_1_381_- FIG00001067 55 9 57 Rubrerythrin Oxidative stress 1.2 T2D_unique_240221_1_440_+ FIG01304601 35 8 37 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_240223_295_440_+ FIG00010844 9 2 10 Flavodoxin Flavodoxin 1 T2D_unique_240243_1_368_- FIG00121768 7 2 9 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_240336_1_440_+ FIG00052605 4 2 6 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_240343_1_440_+ FIG00001062 30 6 32 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_unique_240357_1_330_+ FIG00085033 13 4 14 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_240358_1_440_+ FIG00000504 19 4 21 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_240374_1_440_+ FIG00047414 46 10 47 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_240388_1_154_- FIG00229386 31 5 31 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_240394_1_440_+ FIG00133227 104 16 104 N-acetylneuraminate lyase (EC 4.1.3.3) Sialic Acid Metabolism 1.x T2D_unique_240421_1_440_- FIG00014000 18 6 28 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_240422_1_369_+ FIG00022300 51 10 52 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_240427_238_440_+ FIG00000011 45 7 45 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_240463_1_440_- FIG00007328 38 8 39 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_240478_1_437_+ FIG00001385 121 17 121 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_240488_153_440_- FIG00001550 9 4 10 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_240510_1_440_+ FIG00000333 61 13 62 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_240524_88_440_- FIG00146593 20 4 22 DegV family protein in cluster with TrmH family tRNA/rRNA methyltransferase YacO Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_240527_65_440_- FIG00000402 13 4 15 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_240531_135_440_+ FIG00034851 12 4 13 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_240568_1_440_+ FIG00132617 83 15 84 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_240577_1_440_- FIG00000156 23 5 25 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_240590_1_325_+ FIG00004788 4 3 6 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) Murein Hydrolases 3 T2D_unique_240594_1_440_- FIG00001548 37 6 38 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_240617_1_440_- FIG00000350 9 5 10 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_240635_1_439_- FIG00031250 24 8 25 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_240671_1_439_+ FIG00093180 74 12 75 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_240694_15_251_- FIG00080955 50 8 51 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_240702_1_376_+ FIG00001865 4 3 6 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_240729_116_439_- FIG00019652 70 11 71 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_240733_1_333_+ FIG00002968 12 4 13 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_240735_278_439_- FIG00001818 25 5 26 LSU ribosomal protein L3p (L3e) Ribosome LSU bacterial 9 T2D_unique_240740_1_439_+ FIG00132994 97 15 98 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_240766_1_439_- FIG00002804 112 17 112 Homocysteine S-methyltransferase (EC 2.1.1.10) Methionine Biosynthesis 8 T2D_unique_240774_1_149_- FIG00047414 24 4 25 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_240774_167_439_+ FIG00001618 15 4 16 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_240780_1_439_+ FIG00012945 16 4 17 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_240783_1_439_- FIG00038456 42 7 43 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_240867_1_439_+ FIG00044622 53 9 55 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_240880_197_439_- FIG00005647 11 3 14 Chemotaxis protein CheD Bacterial Chemotaxis 9 T2D_unique_240896_52_439_- FIG00008490 55 11 57 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_240897_1_439_- FIG00005529 4 2 6 Nitrate/nitrite transporter Nitrate and nitrite ammonification 1 T2D_unique_240898_1_439_+ FIG00060517 108 15 108 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_240922_148_439_- FIG00030688 5 3 7 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_240923_1_439_+ FIG00016514 58 11 59 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_240926_1_439_+ FIG00001608 45 9 48 Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NADP) (EC 1.2.1.9) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_240944_1_439_+ FIG00002385 10 4 11 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_240948_1_439_+ FIG00000455 43 9 44 Malate dehydrogenase (EC 1.1.1.37) Serine-glyoxylate cycle 1 T2D_unique_240983_1_439_+ FIG00000477 52 10 53 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_240995_159_439_- FIG00000317 42 7 43 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_241005_83_439_- FIG00076542 31 7 33 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_241010_1_439_- FIG00000762 106 16 106 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_241017_1_439_+ FIG00016566 5 3 6 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_241018_1_295_+ FIG00002914 10 3 12 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_241019_1_439_+ FIG00001642 114 16 114 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_241048_1_439_- FIG01304818 22 4 24 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_241057_1_439_+ FIG00040817 8 4 9 Sugar diacid utilization regulator SdaR D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_241063_155_439_+ FIG00000159 49 10 50 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_241064_284_439_+ FIG00002920 31 6 31 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_241068_1_439_+ FIG00000990 22 5 24 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_241083_1_439_- FIG00000624 61 11 63 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_241109_175_330_+ FIG00031250 4 3 5 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_241110_1_439_- FIG00003394 52 10 54 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_241130_1_439_+ FIG00007147 10 3 13 Glycosyltransferase LafB, responsible for the formation of Gal-Glc-DAG Polyglycerolphosphate lipoteichoic acid biosynthesis 1 T2D_unique_241138_279_439_- FIG00000471 10 3 12 LSU ribosomal protein L34p Cell Division Subsystem including YidCD 1 T2D_unique_241142_1_386_+ FIG00045144 57 12 59 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_241195_23_439_- FIG00000439 21 4 22 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_241260_300_439_+ FIG00002224 15 3 16 protein from nitrogen regulatory protein P-II (GLNB) family, ortholog YAAQ B. subtilis CBSS-393133.3.peg.2787 1 T2D_unique_241312_1_439_+ FIG00000717 42 7 43 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_241325_1_439_+ FIG00026918 122 18 122 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_241360_1_439_- FIG00038343 20 4 21 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_241371_63_439_- FIG00006128 3 2 4 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_241376_101_316_- FIG00013638 40 6 40 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_241381_1_439_+ FIG00001106 18 5 20 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_241394_1_439_- FIG00041038 104 15 105 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_241435_1_438_- FIG00000840 119 16 119 50S ribosomal subunit maturation GTPase RbgA (B. subtilis YlqF) Universal GTPases 2 T2D_unique_241440_267_438_- FIG00001675 17 4 18 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_241464_1_438_+ FIG00074196 15 5 17 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_241476_184_438_- FIG00002470 19 4 21 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_241491_132_438_+ FIG00000494 10 4 11 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_241497_160_438_+ FIG00001170 30 6 31 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_unique_241498_1_318_+ FIG00066425 5 3 6 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_241516_1_438_+ FIG00002344 32 7 33 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_241524_1_438_+ FIG00035627 126 17 126 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_241551_267_438_- FIG00000673 10 4 11 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_unique_241553_1_129_+ FIG01304818 13 3 14 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_241554_1_438_- FIG00023369 69 15 70 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_241562_219_438_- FIG00000552 42 8 42 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_241581_1_438_- FIG00109688 18 5 19 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_241595_48_438_- FIG00025216 60 11 62 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_241603_165_438_+ FIG00000001 9 3 11 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_241631_1_376_- FIG00000154 45 9 46 LSU ribosomal protein L17p Ribosome LSU bacterial 9 T2D_unique_241642_1_374_+ FIG00000036 19 7 20 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_241646_44_438_- FIG00133515 21 5 23 Dihydroorotate dehydrogenase electron transfer subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_241695_1_438_- FIG00016514 28 6 29 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_241698_1_378_+ FIG00001469 11 4 13 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_241711_1_438_+ FIG00003174 127 18 127 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_241731_1_438_+ FIG01260980 75 14 77 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_241746_1_438_- FIG00000402 116 17 116 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_241748_1_438_- FIG00000038 20 8 55 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_241750_1_438_+ FIG00049433 22 7 23 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_241765_1_332_- FIG00000368 88 12 88 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_241809_189_438_+ FIG01955774 67 10 67 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_241825_1_295_- FIG00001469 23 7 24 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_241836_1_347_+ FIG00132787 8 2 9 Prephenate dehydrogenase (EC 1.3.1.12) Phenylalanine and Tyrosine Branches from Chorismate 1 T2D_unique_241844_1_269_+ FIG00045144 65 10 65 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_241876_1_438_+ FIG00003788 114 17 114 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_241877_1_346_+ FIG00138171 16 5 17 Queuosine biosynthesis QueD, PTPS-I Zinc regulated enzymes 1 T2D_unique_241881_1_134_- FIG00007514 16 3 16 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_241898_27_438_+ FIG00000985 6 4 21 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_241910_257_438_- FIG00076542 14 5 15 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_241915_1_438_+ FIG00001902 15 4 16 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_241920_1_438_- FIG00063189 25 6 26 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_241927_274_438_+ FIG00000315 15 4 16 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_241936_1_438_+ FIG00043527 6 2 8 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_241940_1_438_- FIG00000680 4 2 6 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_241952_296_438_+ FIG00000811 10 2 10 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_241968_1_438_+ FIG00000477 14 5 16 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_241985_1_438_+ FIG00093180 23 8 24 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_241990_1_438_- FIG01304636 45 10 47 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_242003_1_438_+ FIG00018699 44 9 45 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_242018_1_438_- FIG00113099 20 6 21 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities CBSS-89187.3.peg.2957 1 T2D_unique_242021_1_341_- FIG00002541 38 8 39 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_242026_1_438_+ FIG00018369 5 2 7 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_242032_1_269_+ FIG00218417 43 7 43 probable beta-D-galactosidase Galactosylceramide and Sulfatide metabolism 7 T2D_unique_242054_1_438_+ FIG00000038 42 8 43 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_242088_1_438_+ FIG00052730 97 15 97 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_242121_1_438_- FIG00008294 90 16 90 Membrane-bound lytic murein transglycosylase D precursor (EC 3.2.1.-) Murein Hydrolases 3 T2D_unique_242134_1_438_+ FIG00000308 40 10 42 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_242136_16_438_- FIG00000101 55 11 56 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_242146_1_438_+ FIG00000539 39 10 56 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_242148_1_174_+ FIG00028203 42 6 42 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_242170_1_438_+ FIG00001548 45 9 48 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_242175_1_438_- FIG00075702 63 12 65 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_242182_125_438_+ FIG00052802 33 7 34 Agmatinase (EC 3.5.3.11) Polyamine Metabolism 2 T2D_unique_242212_1_183_+ FIG00000351 4 2 5 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_242219_236_437_+ FIG00020185 6 3 8 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_242224_1_324_+ FIG00000897 6 2 8 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_242262_1_437_+ FIG00000107 69 11 70 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_242276_1_437_+ FIG00000157 66 12 67 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_242277_1_362_- FIG00000111 73 12 74 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_242299_47_437_+ FIG00001505 36 9 37 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_242300_184_437_+ FIG00067248 30 6 31 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_242305_80_437_+ FIG00002410 10 3 12 Recombinational DNA repair protein RecT (prophage associated) DNA repair, bacterial 3 T2D_unique_242307_1_414_+ FIG00002490 93 16 93 Transcriptional regulator in cluster with unspecified monosaccharide ABC transport system CBSS-257314.1.peg.676 4.x T2D_unique_242308_1_437_+ FIG00000287 33 7 34 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_242383_1_355_+ FIG00084105 10 4 12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_242385_1_437_+ FIG00039528 9 4 11 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) Purine conversions 4.1118100 T2D_unique_242387_1_437_+ FIG00138004 99 14 101 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_242396_1_437_+ FIG00001088 78 13 83 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_242397_1_437_+ FIG00138182 9 6 12 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_242404_1_437_+ FIG01260980 92 14 92 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_242435_4_437_- FIG00002470 18 4 19 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_242439_218_437_+ FIG00000163 17 4 18 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_242472_1_437_+ FIG01260980 15 5 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_242519_1_181_+ FIG00229386 30 5 31 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_242519_217_437_+ FIG00018396 45 8 45 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_242622_1_437_+ FIG00041038 118 18 118 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_242644_1_225_+ FIG00009229 27 6 28 Heat shock protein 60 family co-chaperone GroES GroEL GroES 9 T2D_unique_242687_1_437_+ FIG00000055 123 17 123 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_242689_37_437_+ FIG00000811 21 7 23 ATP phosphoribosyltransferase (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_242711_1_437_+ FIG00000156 12 4 13 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_242719_1_418_+ FIG00133139 5 3 7 Superoxide dismutase [Fe] (EC 1.15.1.1) Oxidative stress 1.2 T2D_unique_242720_1_436_+ FIG00149566 72 15 73 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_242739_1_437_- FIG00000025 68 13 69 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_242750_1_360_+ FIG00031825 56 10 58 Hydrogen peroxide-inducible genes activator DNA-binding regulatory proteins, strays 1 T2D_unique_242776_1_437_- FIG00000022 8 4 9 Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25) Chorismate Synthesis 1 T2D_unique_242782_1_437_- FIG00000474 45 9 47 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_242796_1_352_+ FIG00001298 88 13 88 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_242799_1_209_- FIG00000122 15 3 17 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_242816_1_437_+ FIG00041038 24 6 25 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_242835_1_434_+ FIG00001469 88 12 89 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_242843_1_437_+ FIG00035701 16 6 19 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_242858_1_437_+ FIG00561498 30 9 31 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_242891_1_437_- FIG00561498 48 9 49 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_242918_1_437_- FIG00022300 108 16 108 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_242928_1_437_- FIG00000539 26 6 28 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_242934_274_437_+ FIG00005547 11 3 12 Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.-) CBSS-269801.1.peg.1715 1 T2D_unique_242935_114_437_+ FIG00133209 11 5 12 2-dehydro-3-deoxygluconate kinase (EC 2.7.1.45) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_242956_1_437_+ FIG00046358 80 12 81 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_242957_1_437_- FIG00000422 6 7 26 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_242960_1_437_+ FIG00091940 117 17 117 Histidine ammonia-lyase (EC 4.3.1.3) Histidine Degradation 1.100 T2D_unique_242966_1_437_+ FIG00000595 35 7 36 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_242977_42_437_- FIG00009450 13 4 14 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_243010_1_437_- FIG00000422 53 12 54 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_243021_1_437_- FIG00028694 55 11 56 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_243094_1_436_+ FIG00000101 63 13 64 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_243128_1_436_- FIG00021644 7 3 9 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_243137_1_191_- FIG00000624 20 4 21 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_243183_224_436_- FIG00000070 10 4 11 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_243197_1_295_- FIG00058830 3 3 5 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_243202_1_242_+ FIG00007941 31 8 32 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_243215_1_436_- FIG00024226 4 2 5 Ribose operon repressor D-ribose utilization A.123 T2D_unique_243223_1_436_- FIG00028476 83 13 83 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_243239_1_405_+ FIG00001298 48 8 49 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_243247_1_210_+ FIG00129130 19 4 20 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_243254_1_436_- FIG00009682 27 6 28 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_243291_1_436_+ FIG00093180 9 3 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_243294_191_436_+ FIG00001088 31 5 32 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_243303_1_178_- FIG00000303 21 4 22 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_243303_200_436_+ FIG01260980 8 2 9 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_243324_1_436_+ FIG00031969 101 16 101 capsular polysaccharide biosynthesis protein Rhamnose containing glycans 4.1 T2D_unique_243339_1_436_- FIG00000252 106 17 106 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) One-carbon metabolism by tetrahydropterines 5 T2D_unique_243340_1_142_+ FIG00009628 10 3 11 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_243358_1_436_- FIG01260980 56 13 69 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_243370_32_436_+ FIG00075970 17 5 20 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_243378_1_436_- FIG00000402 19 6 21 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_243399_1_436_- FIG00001555 19 3 21 Cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Putative oxidase COG2907 9 T2D_unique_243400_1_159_+ FIG00093180 8 2 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_243448_1_227_+ FIG00104848 10 2 12 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_243454_1_436_- FIG00000695 25 8 48 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_243461_119_436_- FIG00031250 36 8 38 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_243462_41_436_- FIG00133196 6 3 8 L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_243488_206_436_- FIG00000312 22 6 24 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_243505_115_436_+ FIG00012531 64 10 65 TRAP-type transport system, small permease component, predicted N-acetylneuraminate transporter Sialic Acid Metabolism 1.x T2D_unique_243534_1_292_+ FIG00001175 82 12 82 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_243540_1_436_- FIG00001269 72 11 73 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_243561_1_436_- FIG00000015 36 10 37 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_243568_259_436_+ FIG00846773 38 6 38 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_243647_1_436_+ FIG00000187 37 9 38 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_243699_1_436_- FIG00075970 19 7 23 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_243716_1_436_+ FIG00896278 3 2 4 Cys regulon transcriptional activator CysB DNA-binding regulatory proteins, strays 1 T2D_unique_243717_121_436_- FIG00018699 28 6 29 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_243726_1_436_+ FIG00000207 31 6 33 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_243732_1_436_+ FIG01239241 103 16 103 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_243752_1_436_+ FIG01260980 3 2 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_243755_1_366_+ FIG00000288 15 5 18 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_243758_1_168_+ FIG00001188 23 4 25 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_243758_255_436_- FIG00074196 17 3 18 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_243784_74_388_+ FIG00000504 7 2 9 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_243792_218_436_+ FIG00001882 47 8 47 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_243804_1_239_- FIG00130344 10 3 11 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_243805_8_436_- FIG00002588 53 12 79 Formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) One-carbon metabolism by tetrahydropterines 5 T2D_unique_243818_1_216_+ FIG00023268 24 5 25 DNA-binding protein HU-beta DNA structural proteins, bacterial 1.1100 T2D_unique_243829_1_436_- FIG00000582 25 5 26 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_243841_1_436_+ FIG00067248 28 8 30 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_243842_1_404_- FIG00059211 5 2 6 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_243846_1_436_- FIG00008591 14 4 16 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_243855_29_436_- FIG00000146 32 7 34 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_243862_1_436_- FIG00002066 16 6 18 Cytoplasmic alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_243876_1_436_+ FIG00010078 41 8 42 Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine ECF class transporters 345678 T2D_unique_243885_1_436_+ FIG00000585 71 13 72 Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_243887_86_436_- FIG00136522 93 14 93 Ribonuclease BN (EC 3.1.-.-) LMPTP YfkJ cluster 93 T2D_unique_243901_1_435_+ FIG00007039 3 2 5 Multiple sugar ABC transporter, membrane-spanning permease protein MsmG Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_243921_1_435_- FIG00000080 110 17 111 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_243925_1_435_- FIG00046929 66 12 67 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_243931_1_435_+ FIG00000372 9 3 11 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_243936_1_435_+ FIG00080231 19 6 21 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_243950_1_435_- FIG01955809 10 5 12 Cytoplasmic copper homeostasis protein cutC Copper homeostasis: copper tolerance 3 T2D_unique_243978_1_204_+ FIG00001022 46 8 46 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_243980_1_435_+ FIG00063189 11 6 14 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_243982_1_435_- FIG00004453 111 17 112 FIG004453: protein YceG like CBSS-323097.3.peg.2594 1 T2D_unique_243983_1_435_+ FIG00000242 45 10 46 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_244028_1_435_+ FIG00000117 97 14 98 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_244040_129_435_+ FIG00001179 5 3 6 Macrolide-specific efflux protein MacA Multidrug Resistance Efflux Pumps 1.12 T2D_unique_244056_1_206_- FIG00001561 12 3 13 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_244066_1_260_- FIG00000601 24 6 26 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_244115_1_435_- FIG00719736 54 11 55 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_244128_66_435_+ FIG00140555 6 2 7 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_244131_1_435_+ FIG01260980 121 17 121 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_244142_1_435_- FIG00048014 74 14 78 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_244154_1_435_- FIG00000085 30 8 31 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_244155_97_435_+ FIG00000235 36 9 38 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_244162_19_435_- FIG00008490 98 16 98 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_244181_1_255_+ FIG00038343 11 3 13 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_244188_1_270_+ FIG00042781 38 9 38 Indolepyruvate oxidoreductase subunit IorB (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_244198_1_161_- FIG00005283 38 6 38 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_244199_206_435_+ FIG00000103 10 2 11 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_244235_187_435_- FIG00001264 14 3 15 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_244263_1_435_- FIG00000065 48 9 49 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_244270_1_435_- FIG00000445 51 10 52 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_244272_1_220_- FIG00000402 7 2 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_244279_1_435_+ FIG00059211 13 5 15 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_244286_1_435_- FIG00000335 91 15 92 Twin-arginine translocation protein TatC Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_unique_244319_1_369_+ FIG00000151 16 4 17 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_244321_213_435_- FIG00000497 3 2 4 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB Biogenesis of cytochrome c oxidases 3 T2D_unique_244337_1_435_- FIG00001548 9 3 10 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_244354_1_435_+ FIG00000370 82 14 83 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_244359_1_255_+ FIG00001173 7 2 9 Nitrate/nitrite response regulator protein Nitrate and nitrite ammonification 1 T2D_unique_244363_1_435_- FIG00059211 38 9 40 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_244387_1_435_- FIG00000402 6 2 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_244415_1_435_- FIG00076542 113 17 113 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_244418_1_435_- FIG00000838 36 12 37 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_244431_1_341_- FIG00046929 18 4 20 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_244437_60_435_- FIG00000098 37 7 39 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_244465_1_435_- FIG00018396 17 6 19 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_244488_256_435_- FIG00000121 14 4 16 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_244493_1_435_- FIG00001548 87 14 88 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_244496_1_435_- FIG00004078 30 8 32 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_244512_117_435_- FIG00000532 5 2 6 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_244516_137_435_+ FIG00003090 83 12 83 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_unique_244517_1_435_+ FIG01303775 46 8 46 GTP-binding protein related to HflX Hfl operon 1.111 T2D_unique_244572_1_435_+ FIG00001712 49 10 50 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_244610_1_435_+ FIG00104848 6 3 9 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_244617_65_343_+ FIG00002412 9 5 11 DNA-binding protein HBsu DNA structural proteins, bacterial 1.1100 T2D_unique_244631_1_435_+ FIG00623809 36 8 37 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_244632_1_435_+ FIG00023369 23 8 34 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_244633_1_435_+ FIG00000065 87 14 89 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_244648_1_435_- FIG00001670 37 9 42 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_244651_1_128_- FIG00016888 7 2 8 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_244679_113_435_- FIG00000865 5 3 6 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_244691_1_435_- FIG00024401 121 17 121 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_244695_1_425_+ FIG00077620 21 6 23 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_244718_1_286_- FIG01176807 73 11 73 Xanthine dehydrogenase, FAD binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_244751_1_434_- FIG00032749 3 4 11 Protein YicC CBSS-323097.3.peg.2594 1 T2D_unique_244787_215_434_+ FIG00000396 21 4 22 Uracil phosphoribosyltransferase (EC 2.4.2.9) De Novo Pyrimidine Synthesis 1 T2D_unique_244791_50_434_- FIG00075970 18 5 20 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_244802_1_434_+ FIG00132839 7 2 9 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_244809_1_385_+ FIG00000015 37 7 38 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_244810_1_399_- FIG00132630 38 9 39 Ferric uptake regulation protein FUR Oxidative stress 1.2 T2D_unique_244812_1_434_- FIG00007960 17 5 18 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_244832_1_434_- FIG01304636 41 10 43 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_244836_1_434_+ FIG00000673 8 3 10 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_unique_244839_110_434_- FIG00001561 9 3 11 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_244857_147_434_- FIG00000312 61 10 63 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_244871_1_434_- FIG00000402 15 6 17 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_244880_1_231_+ FIG00049433 57 9 57 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_244882_1_139_+ FIG00000341 8 2 10 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_244939_1_388_+ FIG00000775 88 13 89 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_244940_1_230_- FIG00001076 30 6 31 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_244956_1_434_- FIG00744931 18 6 21 Phage tail assembly Phage tail proteins 2 4 T2D_unique_244962_1_434_+ FIG00038920 6 2 8 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_244984_1_282_- FIG00002914 6 2 9 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_244986_1_434_+ FIG00028203 71 14 74 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_244989_1_434_+ FIG00896278 12 5 19 Cys regulon transcriptional activator CysB DNA-binding regulatory proteins, strays 1 T2D_unique_244998_1_434_- FIG00024851 106 16 106 Transmembrane component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_245021_1_434_+ FIG00016566 12 4 15 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_unique_245040_186_434_+ FIG00719736 63 9 63 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_245056_1_319_- FIG00003530 72 11 73 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_245057_1_434_- FIG00003520 20 7 23 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_245058_1_434_- FIG00000210 88 15 89 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_245062_118_434_- FIG00010524 86 12 86 Aminobenzoyl-glutamate transport protein p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_245109_1_414_+ FIG00002344 52 10 52 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_245121_1_434_- FIG00038343 3 2 4 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_245125_98_434_- FIG00139192 18 6 20 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_245127_1_434_+ FIG00001054 25 8 26 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_245158_1_434_- FIG00009564 118 18 118 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_245160_1_434_+ FIG00561498 118 17 118 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_245161_1_230_- FIG01955782 18 4 19 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_245163_1_434_- FIG00000527 5 2 6 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_245176_1_434_- FIG00054459 30 10 31 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_245179_169_434_- FIG00002332 64 9 64 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_unique_245214_1_434_- FIG00109688 62 11 64 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_245224_1_434_+ FIG00035893 42 8 44 Nickel ABC transporter, periplasmic nickel-binding protein NikA (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_245238_260_434_- FIG00000911 12 4 14 NADH pyrophosphatase (EC 3.6.1.22) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_245247_1_434_- FIG00000210 15 4 18 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_245255_1_434_- FIG00561498 25 5 26 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_245293_1_434_- FIG00000080 112 16 112 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_245304_126_434_+ FIG00002216 46 9 47 Oligopeptidase A (EC 3.4.24.70) Protein degradation 1 T2D_unique_245310_148_434_- FIG00001491 5 3 6 Peroxide stress regulator PerR, FUR family Oxidative stress 1.2 T2D_unique_245326_1_206_- FIG00023946 9 2 11 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_245360_1_434_+ FIG00000132 41 8 43 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_245375_1_323_- FIG00135554 13 4 14 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_245377_1_434_- FIG00049915 36 9 38 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_245420_1_369_+ FIG00719736 34 9 35 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_245436_217_434_+ FIG00007514 6 2 7 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_245446_1_291_- FIG00064110 12 6 14 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_245466_1_126_- FIG00041038 13 2 14 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_245476_272_434_- FIG00001522 7 2 9 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_245494_1_153_+ FIG00001209 3 2 6 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_unique_245498_1_305_- FIG00028694 6 2 8 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_245500_1_424_+ FIG00003555 22 7 24 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_245505_1_434_+ FIG00000290 20 6 21 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_245513_255_434_+ FIG00000355 18 3 19 Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Cell division-ribosomal stress proteins cluster 1 T2D_unique_245533_46_434_- FIG00515041 72 13 73 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Alkanesulfonate assimilation 9.? T2D_unique_245536_1_434_+ FIG00002470 8 4 12 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_245549_84_434_- FIG00000208 79 12 79 Ribonuclease III (EC 3.1.26.3) CBSS-176299.4.peg.1292 3 T2D_unique_245557_80_434_+ FIG00000383 8 2 9 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_245562_273_434_- FIG00044478 3 2 4 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) Histidine Biosynthesis 1 T2D_unique_245566_1_434_- FIG00000812 37 8 38 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_245626_1_433_+ FIG00079740 11 4 13 Xyloside transporter XynT Xylose utilization 1 T2D_unique_245627_280_433_- FIG00000174 35 5 35 LSU ribosomal protein L5p (L11e) Ribosome LSU bacterial 9 T2D_unique_245649_1_433_+ FIG00000714 71 13 72 Membrane alanine aminopeptidase N (EC 3.4.11.2) EC 3.4.11.- Aminopeptidases 1 T2D_unique_245677_1_432_+ FIG00001264 112 16 113 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_245724_1_433_+ FIG00116638 86 15 86 Carboxynorspermidine decarboxylase, putative (EC 4.1.1.-) Polyamine Metabolism 2 T2D_unique_245749_1_180_- FIG00001676 8 2 9 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_245791_152_433_- FIG00000086 9 2 13 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_245794_1_433_- FIG00013347 16 5 18 Stage II sporulation protein related to metaloproteases (SpoIIQ) Sporulation-related Hypotheticals 2.x T2D_unique_245798_1_433_+ FIG00000584 11 8 30 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_245824_1_130_+ FIG00016836 5 3 6 Transcription termination protein NusB Transcription factors bacterial 1 T2D_unique_245824_141_433_+ FIG00000323 63 10 64 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_245834_1_407_+ FIG00000251 113 16 113 Nucleoside diphosphate kinase (EC 2.7.4.6) Purine conversions 4.1118100 T2D_unique_245843_1_185_- FIG00000323 11 3 12 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_245843_212_433_- FIG00016836 9 4 10 Transcription termination protein NusB Transcription factors bacterial 1 T2D_unique_245902_1_243_- FIG00002020 5 2 6 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_245925_1_433_- FIG00001469 118 17 118 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_245928_1_433_+ FIG00000402 44 8 45 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_245936_1_377_- FIG00028476 42 7 44 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_245969_1_433_- FIG00002416 7 3 12 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_245974_1_231_+ FIG00058830 64 9 64 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_246004_1_433_- FIG00745599 54 13 55 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_246009_1_433_- FIG00002974 41 9 43 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_246015_1_433_- FIG00000430 22 5 24 3-dehydroquinate dehydratase II (EC 4.2.1.10) Quinate degradation 3 T2D_unique_246027_1_433_- FIG00034851 8 4 10 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_246033_1_433_+ FIG00059413 106 16 106 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL Dihydroxyacetone kinases 3 T2D_unique_246064_150_433_+ FIG00004078 26 6 27 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_246068_1_433_+ FIG00093180 120 17 120 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_246079_1_323_+ FIG00025216 50 9 51 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_246085_1_433_- FIG00138468 58 10 59 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_246094_143_433_- FIG00000510 11 4 13 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_246139_1_153_+ FIG00000187 18 4 19 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_246152_1_433_+ FIG00001469 9 3 10 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_246165_256_433_- FIG00000390 41 7 41 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_246174_1_433_+ FIG00003174 11 5 12 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_246177_1_433_+ FIG00000242 107 17 107 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_246190_87_263_- FIG00132976 24 6 25 Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33) Acetoin, butanediol metabolism 5 T2D_unique_246204_1_433_- FIG00009194 44 10 45 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_246258_1_433_+ FIG00059211 8 4 9 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_246264_1_207_- FIG00002066 14 3 16 Cytoplasmic alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_246270_1_433_- FIG00024930 15 5 17 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_246273_1_433_+ FIG00000116 108 15 109 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_246274_1_433_- FIG00135469 41 6 44 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_246284_1_433_+ FIG00945384 87 15 87 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_246306_1_176_+ FIG00000504 48 7 48 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_246306_177_433_+ FIG00001253 56 9 56 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_246321_222_433_+ FIG00004651 6 2 7 Dipicolinate synthase subunit A (EC 4.2.1.52) Dipicolinate Synthesis 1 T2D_unique_246323_1_433_- FIG00001675 30 5 32 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_246368_1_433_+ FIG00001647 4 2 5 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_246376_42_433_- FIG01260980 18 4 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_246382_120_433_- FIG00046929 61 9 61 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_246457_1_433_+ FIG00002620 111 17 111 Tyrosine-protein kinase transmembrane modulator EpsC Exopolysaccharide Biosynthesis 1.0 T2D_unique_246467_1_432_- FIG00059211 11 5 14 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_246470_1_432_- FIG00003788 4 3 5 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_246484_1_432_- FIG00003381 10 4 12 L-cystine uptake protein TcyP L-Cystine Uptake and Metabolism 6.0 T2D_unique_246489_1_432_- FIG00046929 78 15 79 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_246493_1_432_- FIG00002268 5 4 7 ATP-dependent DNA ligase (EC 6.5.1.1) clustered with Ku protein, LigD DNA Repair Base Excision 4 T2D_unique_246513_1_432_- FIG00011659 98 15 98 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_246519_1_432_- FIG01304834 6 4 11 Fumarate hydratase class I, anaerobic (EC 4.2.1.2) Serine-glyoxylate cycle 1 T2D_unique_246534_88_432_- FIG00121768 5 2 6 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_246548_1_432_- FIG00093180 8 3 11 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_246571_1_432_+ FIG00001076 41 10 43 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_246596_181_432_- FIG00000159 48 9 49 LSU ribosomal protein L10p (P0) Ribosome LSU bacterial 9 T2D_unique_246603_1_324_- FIG00001011 90 13 90 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_246620_1_432_+ FIG00108342 18 4 20 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_246621_19_432_- FIG00451095 18 5 20 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_246646_1_267_- FIG00001676 12 3 13 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_246661_1_432_+ FIG00018457 7 4 9 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_246671_250_432_+ FIG00042616 34 6 34 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_246675_1_432_+ FIG00000812 9 3 11 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_246711_1_307_+ FIG01298199 37 7 38 Transmembrane component STY3231 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_246727_1_432_+ FIG00061313 11 6 12 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_246733_1_432_- FIG00025216 6 4 17 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_246737_113_432_+ FIG00062547 16 6 17 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_246742_1_432_+ FIG00038611 17 5 18 Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_unique_246752_1_432_+ FIG00003174 7 4 9 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_246754_1_432_- FIG00002803 6 4 8 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_246778_1_432_- FIG00122134 92 16 93 Malolactic regulator Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_246832_1_432_- FIG00000449 76 15 77 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_246857_131_432_+ FIG00000370 40 8 41 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_246862_1_432_- FIG00000793 22 4 23 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_246865_105_432_- FIG00031250 6 2 7 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_246875_1_432_+ FIG01260980 11 7 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_246912_278_432_+ FIG00719736 33 6 33 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_246925_1_432_- FIG00075970 83 14 83 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_246934_87_356_- FIG01954533 63 10 63 Phosphocarrier protein of PTS system Fructose utilization 1 T2D_unique_246937_198_432_- FIG00009156 8 2 9 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_246941_1_160_- FIG00000256 11 3 12 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_246963_1_432_+ FIG00000372 18 8 19 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_246964_1_432_+ FIG00003788 7 5 11 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_246977_1_432_+ FIG00009564 117 16 117 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_246994_16_432_- FIG00000211 103 16 103 LSU ribosomal protein L13p (L13Ae) Ribosome LSU bacterial 9 T2D_unique_247003_1_432_+ FIG00025216 38 8 39 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_247022_1_167_- FIG00000080 5 2 6 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_247042_1_432_- FIG00038814 48 9 49 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_247043_1_432_+ FIG00001469 26 7 28 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_247058_1_403_- FIG00000235 44 8 46 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_247079_1_432_+ FIG00130344 31 7 33 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_247098_1_432_- FIG00002470 8 3 9 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_247111_1_161_+ FIG00000370 15 4 16 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_247114_1_333_+ FIG01260980 9 4 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_247115_1_432_- FIG00000243 7 3 9 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_247136_1_432_+ FIG00041382 87 13 89 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_247146_1_432_+ FIG00000402 74 13 75 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_247148_1_252_+ FIG00051313 44 6 45 ATPase component NikO of energizing module of nickel ECF transporter ECF class transporters 345678 T2D_unique_247157_1_432_+ FIG01260980 5 4 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_247163_1_360_- FIG00001292 78 13 79 D-alanine aminotransferase (EC 2.6.1.21) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_247180_1_251_+ FIG00451095 59 9 60 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_247194_1_234_+ FIG00001505 18 5 19 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_247205_99_432_+ FIG00451095 57 10 59 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_247206_1_432_+ FIG00000089 29 8 30 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_247215_1_431_+ FIG00000402 8 4 11 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_247217_1_431_- FIG00051439 67 13 68 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_247220_21_431_- FIG00048507 60 11 61 Catabolite control protein A HPr catabolite repression system 1 T2D_unique_247228_154_431_- FIG00000812 67 10 67 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_247238_1_431_- FIG00000256 20 9 25 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_247249_1_431_+ FIG00001469 9 3 11 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_247260_1_431_- FIG00000314 4 2 7 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_247300_1_375_+ FIG00025216 28 8 29 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_247308_1_302_- FIG00000328 15 5 16 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_247331_1_431_+ FIG00018392 14 3 16 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_unique_247344_1_431_- FIG00007714 24 5 25 Maltose/maltodextrin ABC transporter, permease protein MalG Maltose and Maltodextrin Utilization 1.x T2D_unique_247362_1_156_+ FIG00000103 9 3 11 Heat shock protein GrpE Protein chaperones 2.0 T2D_unique_247367_1_431_- FIG00002034 18 4 20 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_247379_133_431_+ FIG00000367 62 10 63 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_247382_216_380_- FIG00016145 9 2 10 Arginine decarboxylase (EC 4.1.1.19) Polyamine Metabolism 2 T2D_unique_247410_1_431_+ FIG00006336 111 16 112 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_247432_1_431_- FIG00008230 4 2 7 Two-component sensor kinase yesM (EC 2.7.3.-), associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_247433_1_431_+ FIG00005698 4 4 5 Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) Acetyl-CoA fermentation to Butyrate A T2D_unique_247473_1_410_+ FIG01260980 114 16 114 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_247505_49_431_- FIG00000422 9 3 10 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_247533_1_431_- FIG00000356 46 10 49 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_247556_1_431_+ FIG00000422 20 5 21 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_247564_1_354_+ FIG00028203 14 6 17 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_247569_1_431_+ FIG00001642 14 4 15 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_247603_1_431_+ FIG00000494 13 4 14 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_247605_227_431_+ FIG00000372 3 2 4 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_247618_1_431_- FIG00000139 14 4 15 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_247636_1_347_+ FIG00122145 70 12 70 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_247647_1_354_+ FIG00000102 63 11 64 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_247659_1_431_+ FIG00023943 112 17 112 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_247664_1_279_+ FIG00020185 24 7 25 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_247664_281_431_+ FIG00006551 7 2 7 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_247672_1_431_- FIG00000861 116 17 116 Gluconokinase (EC 2.7.1.12) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_247679_152_431_- FIG00007039 3 2 4 Multiple sugar ABC transporter, membrane-spanning permease protein MsmG Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_247700_1_431_+ FIG00005487 29 7 30 Glutamine amidotransferase, class-II Ammonia assimilation 1 T2D_unique_247731_1_431_- FIG00001732 78 12 79 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_247746_1_431_+ FIG00010600 8 5 9 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_247758_216_431_- FIG00084105 6 2 7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_247767_1_243_- FIG00006945 32 7 33 Anaerobic sulfite reductase subunit B Anaerobic respiratory reductases 3 T2D_unique_247794_1_431_+ FIG00000476 78 13 78 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_247813_1_431_- FIG00006997 14 4 16 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_247821_1_221_- FIG00002194 5 2 6 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_247841_1_263_- FIG01290653 13 3 14 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_247860_1_431_+ FIG00001469 29 8 31 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_247963_1_431_+ FIG00002487 93 16 93 Heptaprenyl diphosphate synthase component II (EC 2.5.1.30) Isoprenoid scratch 1 T2D_unique_247968_1_296_- FIG00075702 25 6 26 Glycerol kinase (EC 2.7.1.30) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_248033_1_431_+ FIG00022300 33 10 34 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_248048_1_266_+ FIG00000433 74 10 74 Acetolactate synthase small subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_248060_1_431_- FIG00000056 66 14 67 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_248124_1_430_+ FIG00006699 37 8 39 CRISPR-associated protein, Csm1 family CRISPR-associated cluster 1 T2D_unique_248147_1_131_+ FIG00058830 30 5 30 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_248147_181_430_+ FIG00000043 65 10 65 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_248151_266_430_- FIG00127025 30 5 31 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_248152_1_427_+ FIG00022300 120 17 120 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_248158_1_430_+ FIG00140555 106 16 108 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_248164_67_430_+ FIG01007502 3 3 5 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_248171_1_430_+ FIG00060517 3 2 5 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_248172_1_430_- FIG00007957 98 16 98 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_248191_1_332_+ FIG00000145 68 10 71 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_248201_1_430_+ FIG00018699 6 4 7 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_248209_231_430_- FIG00000404 49 7 49 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_248248_1_430_+ FIG00006463 45 9 46 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_248254_218_430_- FIG00001642 8 3 9 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_248325_1_232_- FIG00001067 23 6 24 Rubrerythrin Oxidative stress 1.2 T2D_unique_248354_1_430_- FIG00000986 35 8 36 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_248387_1_408_+ FIG01280345 62 12 63 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_248409_193_430_- FIG00000402 6 2 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_248419_24_430_- FIG00000831 22 5 23 Na+/H+ antiporter NhaA type Na(+) H(+) antiporter 1 T2D_unique_248424_1_430_- FIG00000439 52 10 54 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_248426_1_430_- FIG00000139 31 8 32 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_248497_1_430_+ FIG00001548 9 3 13 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_248499_1_192_- FIG00001022 8 2 9 Phosphomannomutase (EC 5.4.2.8) Mannose Metabolism 2.0 T2D_unique_248503_2_430_- FIG00000056 63 13 65 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_248524_1_430_+ FIG00005022 39 9 40 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_248542_1_430_+ FIG00774823 35 7 36 Conservative hypothetical protein probably involved in hydantoin, pyrimidine utilization Hydantoin metabolism 4 T2D_unique_248565_122_310_+ FIG00000645 19 4 20 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_248583_1_430_+ FIG00000139 26 7 27 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_248596_1_430_+ FIG00051161 9 4 23 3'-phosphoadenosine 5'-phosphosulfate sulfurtransferase DndC DNA phosphorothioation 1 T2D_unique_248622_160_430_+ FIG00035175 24 5 35 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_248629_292_430_+ FIG00051439 20 3 21 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_248684_1_422_+ FIG00000659 6 2 7 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_248699_1_430_+ FIG00001469 8 4 10 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_248700_1_430_- FIG00024401 16 6 17 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_248703_1_430_- FIG00006463 3 4 5 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_248704_1_430_- FIG00086220 17 6 20 Oligo-1,6-glucosidase (EC 3.2.1.10) Maltose and Maltodextrin Utilization 1.x T2D_unique_248710_1_430_- FIG00007957 5 3 6 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_248721_1_430_- FIG00018699 102 16 103 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_248779_1_278_- FIG00001469 4 2 5 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_248782_251_430_- FIG00132994 7 2 8 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_248787_1_360_+ FIG00000080 12 4 14 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_248803_241_430_- FIG00002588 11 4 12 Formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) One-carbon metabolism by tetrahydropterines 5 T2D_unique_248810_1_231_- FIG01305829 45 7 46 N-Acetyl-D-glucosamine permease 2, possible Chitin and N-acetylglucosamine utilization 2 T2D_unique_248819_1_430_+ FIG01260980 40 6 42 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_248830_1_430_- FIG00004764 66 13 67 Ammonium transporter Ammonia assimilation 1 T2D_unique_248868_1_430_- FIG00047509 33 9 34 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_248869_1_373_+ FIG00000408 49 10 50 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_248873_1_430_- FIG00000494 75 12 76 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_248876_233_430_+ FIG00000442 48 7 48 Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_248908_1_430_- FIG00000116 13 3 15 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_248918_1_356_+ FIG00001470 82 13 82 Signal recognition particle associated protein Two cell division clusters relating to chromosome partitioning 1 T2D_unique_248932_1_430_+ FIG00000279 15 5 18 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_248936_1_246_+ FIG00002224 5 3 7 protein from nitrogen regulatory protein P-II (GLNB) family, ortholog YAAQ B. subtilis CBSS-393133.3.peg.2787 1 T2D_unique_248949_16_213_- FIG00134342 4 3 6 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_248949_245_429_+ FIG00021289 5 4 6 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_248956_1_429_+ FIG00475203 115 17 115 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_248957_1_429_- FIG00000350 19 6 20 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_248964_1_429_- FIG00000990 56 11 61 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_248971_142_429_- FIG00000131 42 8 43 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_248983_1_349_- FIG00126843 7 2 8 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_248995_123_429_- FIG00003769 5 2 6 Stage III sporulation protein AE Sporulation Cluster III A 1.x T2D_unique_249006_1_429_- FIG00001522 111 16 113 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_249008_1_429_+ FIG00007059 13 4 17 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_249020_123_429_+ FIG00132586 5 3 6 NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) Redox-dependent regulation of nucleus processes 2 T2D_unique_249022_180_429_+ FIG00001865 3 2 5 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_249023_1_429_- FIG00000402 13 7 18 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_249046_1_429_+ FIG00018369 109 17 109 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_249062_1_335_+ FIG00007137 28 7 29 Multiple sugar ABC transporter, substrate-binding protein Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_249072_1_184_- FIG00000522 31 6 31 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_249091_225_429_+ FIG00003435 15 4 16 High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_249104_1_429_+ FIG00000134 15 3 16 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_249106_1_429_+ FIG00022899 57 12 58 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_249127_1_429_- FIG01303822 89 14 89 Hypothetical protein VC0266 (sugar utilization related?) VC0266 1 T2D_unique_249128_1_291_+ FIG00000838 3 2 4 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_249138_92_429_- FIG00000173 26 6 27 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_249165_16_429_- FIG00000134 14 3 15 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_249178_1_429_- FIG00000522 73 14 74 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_249206_1_429_+ FIG00000332 107 16 107 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_249207_1_282_- FIG00001067 4 3 5 Rubrerythrin Oxidative stress 1.2 T2D_unique_249216_1_135_- FIG00003012 9 3 10 His repressor CBSS-393121.3.peg.1913 1 T2D_unique_249221_1_176_- FIG00003307 13 4 15 FIG003307: hypothetical protein CBSS-323097.3.peg.2594 1 T2D_unique_249221_218_429_- FIG00032749 15 5 16 Protein YicC CBSS-323097.3.peg.2594 1 T2D_unique_249252_1_429_- FIG01290653 6 4 10 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_249255_1_429_- FIG00000997 5 3 6 Protein RtcB RNA 3'-terminal phosphate cyclase 2 T2D_unique_249258_62_429_- FIG01322883 21 4 22 rhamnogalacturonan acetylesterase L-rhamnose utilization 1 T2D_unique_249265_1_429_- FIG00007658 97 16 98 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_249294_1_429_+ FIG00000070 3 2 5 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_249310_1_429_+ FIG00561498 7 4 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_249315_270_429_+ FIG00000139 17 4 18 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_249351_1_429_- FIG00011423 115 17 115 Ferredoxin reductase Anaerobic respiratory reductases 3 T2D_unique_249390_1_429_- FIG00002034 13 5 14 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_249394_1_429_+ FIG00009194 10 3 12 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_249412_1_132_- FIG00000531 14 3 15 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_249414_127_429_- FIG00000877 71 11 71 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_249437_1_429_+ FIG00000402 6 2 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_249465_1_429_- FIG00002620 3 2 5 Tyrosine-protein kinase transmembrane modulator EpsC Exopolysaccharide Biosynthesis 1.0 T2D_unique_249469_1_429_- FIG00000001 74 13 75 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_249482_1_429_+ FIG00000392 46 10 47 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_249515_1_429_- FIG00002470 117 17 117 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_249523_1_429_- FIG00026918 22 7 24 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_249556_1_429_+ FIG00093180 39 8 40 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_249569_1_429_- FIG01268363 9 4 11 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_249580_1_139_+ FIG00002332 37 5 37 Inositol-1-monophosphatase (EC 3.1.3.25) Inositol catabolism 5.x T2D_unique_249580_242_429_+ FIG00016412 32 7 32 Prokaryotic ubiquitin-like protein Pup Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_unique_249582_35_277_- FIG00000193 44 8 45 SSU ribosomal protein S16p KH domain RNA binding protein YlqC 1.11 T2D_unique_249591_1_150_- FIG00022300 9 4 10 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_249602_160_429_- FIG00010818 19 5 20 L-serine dehydratase, beta subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_249604_1_429_- FIG00000080 3 2 4 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_249618_1_429_- FIG00004170 25 6 28 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_249623_1_429_+ FIG00136692 105 17 105 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_249639_1_308_- FIG00060517 6 2 10 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_249648_1_429_- FIG00004078 67 12 68 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_249655_1_429_+ FIG00000560 101 15 102 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_249679_1_429_- FIG00012267 108 16 110 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_249685_198_429_+ FIG00000782 3 3 4 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_249691_37_429_- FIG01956071 3 4 5 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_unique_249693_182_429_+ FIG00051957 64 10 64 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_249721_1_429_- FIG01260980 17 6 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_249745_1_429_- FIG00066643 74 12 75 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_249756_1_213_+ FIG00005628 31 6 32 KH domain RNA binding protein YlqC KH domain RNA binding protein YlqC 1.11 T2D_unique_249766_1_429_+ FIG00026918 26 6 29 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_249775_234_429_+ FIG00000450 15 4 16 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_249789_1_428_+ FIG00008591 4 3 11 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_249803_1_428_- FIG00007941 75 12 75 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_249804_1_428_+ FIG00000962 93 14 95 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_249813_271_428_+ FIG00000762 20 4 20 Carbamate kinase (EC 2.7.2.2) Polyamine Metabolism 2 T2D_unique_249820_1_369_+ FIG00380575 8 3 9 Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12) Peptide methionine sulfoxide reductase 1 T2D_unique_249822_1_428_- FIG00043527 18 6 21 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_249841_1_428_- FIG00024401 103 16 103 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_249842_1_428_- FIG00016514 28 6 30 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_249861_1_428_+ FIG00018396 10 4 12 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_249864_1_428_- FIG00052867 13 4 14 Predicted rhamnose oligosaccharide ABC transport system, permease component 2 L-rhamnose utilization 1 T2D_unique_249913_1_428_+ FIG00034851 5 2 9 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_249941_1_428_+ FIG00000126 95 16 95 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_249960_1_428_- FIG00001635 3 4 7 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_249963_192_428_- FIG00000001 56 9 56 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_249967_1_207_+ FIG00004021 47 7 47 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_249974_1_428_- FIG00000102 50 11 53 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_249979_1_428_- FIG00007960 114 15 115 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_249997_1_428_- FIG00048014 39 9 41 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_250002_1_428_- FIG00000372 18 6 19 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_250016_1_428_- FIG00000446 104 16 104 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_250020_1_428_+ FIG00000842 109 17 109 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_250082_1_428_+ FIG00000838 32 5 33 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_250088_1_428_- FIG00080955 16 7 17 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_250093_1_257_+ FIG00064110 10 5 12 Cysteine synthase (EC 2.5.1.47) Methionine Biosynthesis 8 T2D_unique_250101_1_428_- FIG00000372 101 16 101 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_250114_1_428_+ FIG00093180 19 3 21 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_250120_1_428_- FIG01030833 15 4 17 dTDP-Rha:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase WbbL dTDP-rhamnose synthesis 2.0 T2D_unique_250135_1_206_- FIG00003949 26 5 27 Fucose permease L-fucose utilization 1 T2D_unique_250143_1_401_+ FIG00004169 88 14 89 Putative deoxyribose-specific ABC transporter, permease protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_250154_172_428_+ FIG00001414 16 4 18 Cell division initiation protein DivIVA Cell Division Cluster 1.x T2D_unique_250156_1_428_+ FIG00000140 104 15 105 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_250169_1_428_- FIG00028694 31 9 33 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_250175_1_428_+ FIG00001119 32 7 38 Glycerol-3-phosphate regulon repressor, DeoR family Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_250177_1_428_+ FIG00024073 121 17 121 Galactokinase (EC 2.7.1.6) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_250179_1_428_+ FIG00093180 70 10 71 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_250249_1_382_+ FIG00003631 94 15 94 Glutamate--cysteine ligase (EC 6.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_250273_1_428_- FIG00000156 68 12 69 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_250279_1_428_+ FIG00000494 43 9 45 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_250308_1_428_+ FIG00030191 21 6 22 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_250326_1_211_- FIG00001548 4 2 5 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_250402_1_428_+ FIG00022300 52 9 53 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_250410_1_428_+ FIG00038814 3 2 5 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_250417_1_428_+ FIG00008736 19 5 20 Predicted transcriptional regulator of pyridoxine metabolism Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_250432_1_428_+ FIG00051439 76 12 77 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_250451_127_428_- FIG00000155 12 5 14 SSU ribosomal protein S5p (S2e) Ribosomal protein S5p acylation 1 T2D_unique_250461_1_428_- FIG00000402 7 3 8 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_250473_1_428_- FIG00017431 20 6 22 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_unique_250484_1_428_- FIG00132617 37 9 37 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_250510_24_305_- FIG00132839 65 10 66 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_250534_1_416_- FIG00006463 95 15 95 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_250550_1_251_- FIG00000221 11 2 13 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_250582_1_428_- FIG00229199 10 4 12 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_250598_1_428_- FIG01260980 47 9 49 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_250612_1_179_+ FIG00136193 40 6 40 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_250622_1_223_- FIG00020613 7 2 8 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_250651_1_427_- FIG00133325 81 15 82 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_250655_1_321_- FIG00000402 32 6 33 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_250656_174_427_+ FIG00000645 12 4 13 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_250666_86_427_+ FIG00130344 26 6 27 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_250680_1_427_+ FIG00002034 16 5 17 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_250712_65_427_- FIG00016663 94 14 94 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_250721_1_427_- FIG00139192 35 9 36 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_250750_1_310_+ FIG00001401 75 11 75 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_250754_1_280_- FIG00000397 32 6 34 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_250763_1_427_- FIG00054459 46 10 48 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_250788_1_427_- FIG00048014 52 9 57 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_250799_1_427_- FIG00134486 10 7 15 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_250823_1_427_+ FIG00134135 51 9 53 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_250843_1_427_- FIG00031250 57 12 58 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_250852_147_427_+ FIG00001088 3 3 4 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_250857_1_427_+ FIG00003577 100 16 100 LysR family transcriptional regulator YneJ DNA-binding regulatory proteins, strays 1 T2D_unique_250865_1_427_- FIG00001518 7 3 9 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_250866_1_427_+ FIG00000308 26 8 27 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_250877_1_427_+ FIG00000241 68 14 69 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_250884_1_427_+ FIG00000117 105 17 106 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_250925_1_427_- FIG00009194 111 16 112 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_250930_1_427_+ FIG00001798 85 14 86 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_250975_6_137_- FIG00000539 10 2 10 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_250991_1_427_- FIG00000242 47 10 56 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_250992_1_427_+ FIG00000308 3 3 6 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_250997_1_427_+ FIG00048014 28 6 29 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_251008_1_427_- FIG00011382 7 4 9 Membrane proteins related to metalloendopeptidases CBSS-393121.3.peg.2760 1 T2D_unique_251010_143_427_+ FIG00000219 16 5 18 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_251025_1_427_+ FIG00057709 4 3 6 DNA polymerase III delta prime subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_251091_9_427_- FIG00000075 17 5 19 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_251094_1_427_+ FIG00073301 4 2 5 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_251117_1_427_+ FIG00003174 17 6 18 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_251126_1_196_+ FIG00133143 6 3 7 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) Cysteine Biosynthesis 2.17 T2D_unique_251159_221_427_+ FIG00002065 7 2 8 Glyoxylate carboligase (EC 4.1.1.47) Allantoin Utilization X T2D_unique_251173_1_427_+ FIG00000279 34 7 35 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_251182_1_228_- FIG00004743 9 3 11 Lactoylglutathione lyase (EC 4.4.1.5) Methylglyoxal Metabolism 3.x T2D_unique_251185_1_338_- FIG00003881 70 10 70 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_251189_244_427_- FIG00000176 29 5 30 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_251196_1_427_+ FIG00010844 86 16 88 Flavodoxin Flavodoxin 1 T2D_unique_251200_1_210_+ FIG00000434 43 8 45 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_251200_225_427_+ FIG00146664 47 7 47 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_251202_1_427_- FIG00003596 43 11 45 RNA polymerase sporulation specific sigma factor SigF Transcription initiation, bacterial sigma factors 1 T2D_unique_251209_1_427_+ FIG00006128 3 3 4 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_251221_1_427_+ FIG00047056 35 8 37 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_251232_1_427_+ FIG00007586 109 17 109 Multiple sugar ABC transporter, membrane-spanning permease protein MsmF Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_251294_1_427_+ FIG00229386 6 3 10 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_251316_35_427_+ FIG00000388 14 3 15 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_251320_1_235_- FIG00041038 4 2 6 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_251331_1_427_+ FIG00046929 16 7 21 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_251333_1_427_- FIG00000660 4 5 9 Cystathionine gamma-synthase (EC 2.5.1.48) Methionine Biosynthesis 8 T2D_unique_251342_1_427_+ FIG00093180 17 5 18 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_251392_1_427_+ FIG00001547 10 3 12 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_251405_285_427_+ FIG00000397 12 4 13 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_251431_1_328_+ FIG00020533 9 4 13 Sucrose permease, major facilitator superfamily Sucrose utilization 1.1x T2D_unique_251446_1_372_+ FIG00000194 67 11 68 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_251475_1_342_- FIG00138004 64 10 64 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_251495_1_426_+ FIG00125395 30 9 32 Teichoic acid translocation permease protein TagG Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_251504_146_426_+ FIG00000521 59 10 59 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_unique_251520_112_426_+ FIG00000412 6 2 7 DNA recombination and repair protein RecF Cell Division Subsystem including YidCD 1 T2D_unique_251524_1_265_- FIG00000107 38 7 39 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_251539_1_426_- FIG00058830 110 16 110 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_251540_134_426_+ FIG00022899 4 2 6 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_251581_1_408_+ FIG00047509 87 15 88 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_251588_1_426_- FIG00018369 41 10 42 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_251591_1_426_- FIG00016110 27 9 41 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_251617_119_426_- FIG00000175 14 3 15 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_251622_1_302_- FIG00001194 70 11 70 Rrf2 family transcriptional regulator, group III Rrf2 family transcriptional regulators 4 T2D_unique_251631_105_426_- FIG00021407 7 4 8 (R)-citramalate synthase (EC 2.3.1.182) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_251668_1_426_+ FIG00000075 9 4 10 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_251686_1_426_- FIG00041038 5 2 6 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_251693_207_426_+ FIG00000329 7 2 8 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_251705_1_426_- FIG00000933 37 8 38 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_unique_251732_1_426_+ FIG00132839 49 8 50 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_251777_1_426_- FIG00139192 12 4 14 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_251782_275_426_- FIG00006278 26 4 27 Glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42) CBSS-316057.3.peg.3521 1 T2D_unique_251791_1_426_- FIG00000414 9 3 10 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_251803_102_426_+ FIG00002216 6 3 8 Oligopeptidase A (EC 3.4.24.70) Protein degradation 1 T2D_unique_251809_1_426_- FIG00002689 17 5 18 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_251820_1_426_+ FIG00001469 20 5 22 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_251852_1_426_- FIG00001635 70 13 71 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_251853_21_426_- FIG00000402 36 6 37 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_251860_1_426_- FIG00138468 115 16 116 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_251880_1_195_+ FIG01280345 9 4 12 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_251888_1_426_- FIG00000043 104 17 105 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_251891_1_426_- FIG00003394 9 2 13 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_251900_1_185_- FIG00002560 37 6 37 V-type ATP synthase subunit C (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_251902_1_426_- FIG00000456 98 15 98 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_251934_1_426_- FIG00020370 4 4 7 Phage tape measure Phage tail proteins 2 4 T2D_unique_251945_1_426_+ FIG00000962 99 16 101 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_251947_1_256_+ FIG00000571 28 5 29 Signal transduction histidine kinase CheA (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_unique_251951_1_426_+ FIG00000356 16 7 18 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_251958_1_426_- FIG00007059 35 9 37 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_251964_1_426_- FIG00018699 21 8 22 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_251979_1_426_- FIG00000245 13 3 15 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_251990_250_426_- FIG01304636 35 7 35 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_252030_1_426_- FIG00022300 71 14 73 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_252130_1_309_+ FIG00340292 5 3 6 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_252131_1_426_- FIG00008656 114 16 114 Regulatory protein (induces abgABT, used to catabolize p-aminobenzoyl-glutamate) p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_252144_1_426_- FIG00719736 99 15 100 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_252165_1_399_+ FIG00093180 7 3 8 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_252184_1_205_+ FIG00138258 6 3 7 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_252187_256_426_- FIG00135469 12 2 13 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_252189_70_219_- FIG00002958 29 5 29 FIG002958: hypothetical protein Hypothetical Coupled to RecF 1 T2D_unique_252192_1_303_+ FIG00005022 26 4 28 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_252201_70_426_+ FIG01280345 32 7 33 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_252206_1_426_- FIG00059426 30 9 31 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_252221_1_426_- FIG00059211 45 7 46 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_252234_12_426_+ FIG00003086 5 3 7 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_252241_1_426_- FIG00138258 11 2 12 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_252246_1_426_- FIG00719736 91 14 91 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_252259_1_426_+ FIG00011537 103 16 103 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_252262_1_426_+ FIG00003949 74 12 75 Fucose permease L-fucose utilization 1 T2D_unique_252292_1_332_- FIG00001548 41 8 42 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_252296_28_426_+ FIG00005727 19 6 21 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_252309_1_227_+ FIG00016663 8 3 9 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_252341_130_426_- FIG00846773 19 6 20 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_252352_1_426_- FIG00000404 33 9 34 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_252354_1_426_+ FIG00003472 77 13 79 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_252355_1_338_- FIG00034392 14 6 16 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_252381_1_426_- FIG00000075 22 8 26 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_252400_1_425_+ FIG00140555 19 3 20 V-type ATP synthase subunit I (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_252408_1_425_+ FIG00001616 31 7 32 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_252417_1_425_+ FIG00029868 35 9 36 Epi-inositol hydrolase (EC 3.7.1.-) Inositol catabolism 5.x T2D_unique_252455_125_425_+ FIG00024546 12 4 13 Phosphonoacetaldehyde hydrolase (EC 3.11.1.1) Phosphonate metabolism 1 T2D_unique_252481_1_287_- FIG00000151 38 8 39 Peptidyl-tRNA hydrolase (EC 3.1.1.29) Cell division-ribosomal stress proteins cluster 1 T2D_unique_252533_1_425_+ FIG00001882 13 7 19 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_252541_1_425_+ FIG00561498 3 2 9 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_252545_1_425_+ FIG00138468 42 8 45 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_252550_1_425_- FIG00000185 78 14 79 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_252582_1_425_- FIG00010442 97 13 97 Transmembrane component BL0694 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_252596_1_425_- FIG00003997 114 16 114 Protein with similarity to RtcB Translation termination factors bacterial 1.13 T2D_unique_252598_24_425_- FIG00015468 86 14 86 Substrate-specific component PdxU of predicted pyridoxine ECF transporter ECF class transporters 345678 T2D_unique_252601_1_425_+ FIG00041038 71 13 73 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_252602_1_425_- FIG00000113 45 10 47 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_252609_1_229_+ FIG00000350 7 4 9 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_252643_1_425_+ FIG00000184 5 2 7 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_252664_288_425_+ FIG00089781 7 2 8 Possible alpha-xyloside ABC transporter, permease component Xylose utilization 1 T2D_unique_252667_1_425_+ FIG00060517 25 6 26 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_252675_1_425_- FIG01260980 113 16 113 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_252705_1_425_+ FIG00126843 106 16 106 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_252723_1_425_- FIG00000207 102 16 102 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_252756_1_425_- FIG00000990 18 5 20 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_252770_1_425_- FIG00109688 10 2 11 Glycogen debranching enzyme (EC 3.2.1.-) Glycogen metabolism 3 T2D_unique_252838_1_240_- FIG00000397 4 3 6 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_252841_1_374_+ FIG00007495 14 4 16 Spore maturation protein B Spore Core Dehydration 1.1 T2D_unique_252865_34_425_- FIG00049433 22 5 23 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_252870_1_425_- FIG00006128 99 13 100 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_252873_1_375_+ FIG00000421 26 8 27 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_252899_1_425_+ FIG00001865 69 12 71 Rhamnulokinase (EC 2.7.1.5) L-rhamnose utilization 1 T2D_unique_252900_1_425_+ FIG00000721 16 6 18 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_252903_1_126_- FIG00036983 14 4 15 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_252905_1_212_- FIG01304590 19 4 21 Uracil-xanthine permease Purine Utilization 1 T2D_unique_252913_1_253_- FIG00092649 21 5 23 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_252916_106_425_- FIG00000477 50 10 51 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_252958_1_279_- FIG00000476 10 2 11 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_252983_1_425_- FIG00042616 32 6 35 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_252989_1_425_+ FIG00000107 28 6 29 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_253000_1_425_- FIG00066575 7 4 8 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_253016_86_425_+ FIG01304886 3 3 5 Electron transfer flavoprotein, beta subunit Hemin transport system 1 T2D_unique_253018_1_413_+ FIG00093180 8 4 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_253019_115_425_- FIG00000402 12 3 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_253023_1_425_- FIG00007957 10 3 11 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_253029_1_128_- FIG00001188 7 2 8 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_253031_1_425_+ FIG00049336 101 16 101 Foldase protein PrsA precursor (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_253033_1_257_+ FIG00005103 10 2 12 LysR family transcriptional regulator YfiE DNA-binding regulatory proteins, strays 1 T2D_unique_253034_1_425_- FIG00000088 60 12 61 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_253040_1_425_+ FIG00138004 113 16 115 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_253058_1_425_+ FIG00001384 87 16 87 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_253072_152_425_- FIG00000782 3 3 4 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_253082_44_425_- FIG00000023 13 3 15 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_unique_253095_1_425_+ FIG00050854 6 6 8 Tricarboxylate transport protein TctC Tricarboxylate transport system 1.x T2D_unique_253145_1_425_- FIG00000824 11 4 12 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_253169_1_333_+ FIG00001505 19 7 21 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_253175_1_425_- FIG00132617 10 4 11 ATP-dependent protease La (EC 3.4.21.53) Type I Proteasome bacterial 1 T2D_unique_253178_1_425_- FIG00000242 98 16 98 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_253214_1_425_- FIG00022300 10 4 11 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_253220_1_309_+ FIG00001328 26 6 27 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_unique_253223_1_405_+ FIG00094401 56 10 56 Lacto-N-biose phosphorylase (EC 2.4.1.211) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_253273_1_425_- FIG00007157 19 6 20 Alpha-N-arabinofuranosidase (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_253276_1_294_- FIG00000387 68 11 68 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_253285_1_425_- FIG00046929 104 16 104 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_253290_18_425_+ FIG00000866 7 2 9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_253307_1_425_- FIG00001695 109 17 109 D-serine dehydratase (EC 4.3.1.18) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_253360_55_424_- FIG00000176 54 11 56 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_253369_1_424_- FIG01260980 16 4 19 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_253388_1_150_+ FIG00067248 32 5 32 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_253394_193_424_+ FIG00025086 48 9 48 Xanthine permease Purine Utilization 1 T2D_unique_253396_1_365_+ FIG00034392 14 5 15 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_253423_1_424_+ FIG00001469 31 7 32 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_253449_1_368_- FIG00058830 40 7 41 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_253453_1_321_+ FIG00002553 85 12 86 Starvation sensing protein RspA Carbon Starvation 1.21 T2D_unique_253491_195_424_- FIG00000184 11 4 13 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_253499_1_424_- FIG00001469 100 16 101 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_253507_197_424_+ FIG00029916 46 8 46 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_253532_1_228_+ FIG00000298 60 9 60 GTP-binding protein EngB Universal GTPases 2 T2D_unique_253539_1_424_+ FIG00121768 11 4 12 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_253601_1_215_- FIG00001750 19 4 20 Carbon starvation protein A Carbon Starvation 1.21 T2D_unique_253645_19_424_- FIG00136692 38 8 40 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_253646_1_332_+ FIG00000494 17 4 18 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_253656_1_339_- FIG00012067 75 13 75 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_253663_1_357_- FIG00000207 16 4 18 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_253699_1_424_+ FIG00000184 31 6 32 Putative deoxyribonuclease YcfH YcfH 3 T2D_unique_253714_1_333_- FIG00002944 80 12 80 Glycogen biosynthesis protein GlgD, glucose-1-phosphate adenylyltransferase family Glycogen metabolism 3 T2D_unique_253721_1_424_+ FIG00126843 64 11 65 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_253724_1_424_- FIG00001469 27 7 28 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_253745_1_424_+ FIG00006463 82 13 83 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_253753_1_424_- FIG00001687 7 5 8 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_253783_1_424_+ FIG00000477 14 5 16 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_253792_1_424_+ FIG00005022 107 16 108 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_253803_1_311_+ FIG00009544 5 3 6 Late competence protein ComEA, DNA receptor Gram Positive Competence 3100 T2D_unique_253809_78_424_+ FIG00000128 55 12 56 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_253820_1_424_- FIG01260980 9 4 11 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_253848_1_424_+ FIG00000521 42 8 43 rRNA small subunit methyltransferase, glucose inhibited division protein GidB Cell Division Subsystem including YidCD 1 T2D_unique_253853_1_424_+ FIG00001469 88 14 89 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_253883_1_424_- FIG00028203 71 11 72 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_253906_1_424_+ FIG00001076 9 2 12 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_253913_1_424_- FIG00009417 93 15 93 Gluconate permease, Bsu4004 homolog D-gluconate and ketogluconates metabolism 1.3 T2D_unique_253915_262_424_+ FIG00000258 29 5 29 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) Histidine Biosynthesis 1 T2D_unique_253931_266_424_+ FIG00002460 16 3 17 V-type ATP synthase subunit D (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_253945_1_424_- FIG00000721 21 6 22 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_253957_1_424_+ FIG00006868 8 4 12 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_253962_151_424_+ FIG00008572 4 3 7 Cadmium efflux system accessory protein Cadmium resistance 1 T2D_unique_253965_1_424_+ FIG00001134 69 11 71 DNA-3-methyladenine glycosylase II (EC 3.2.2.21) DNA Repair Base Excision 4 T2D_unique_253966_147_424_+ FIG00000770 27 7 28 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_253997_1_424_+ FIG00067248 92 16 92 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_254032_1_424_- FIG00010844 45 10 48 Flavodoxin Flavodoxin 1 T2D_unique_254039_1_372_- FIG00003751 4 6 10 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_254042_1_424_- FIG00067681 4 2 6 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_254045_1_424_- FIG00008507 15 6 16 Endopeptidase spore protease Gpr (EC 3.4.24.78) Small acid-soluble spore proteins 1 T2D_unique_254073_55_424_+ FIG00000040 36 8 38 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_254092_1_146_+ FIG00000376 8 2 9 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_254094_1_424_+ FIG00073301 21 5 22 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_254110_1_424_+ FIG00003955 43 9 46 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_unique_254115_1_424_+ FIG00138205 36 7 49 Uptake hydrogenase large subunit (EC 1.12.99.6) Hydrogenases 2 T2D_unique_254122_1_291_- FIG01016270 5 3 7 tRNA pseudouridine synthase B (EC 4.2.1.70) CBSS-138119.3.peg.2719 9 T2D_unique_254145_1_276_- FIG00077620 6 2 7 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_254191_1_214_- FIG00001548 61 8 61 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_254194_127_423_+ FIG00006700 3 2 6 RNA binding protein, contains ribosomal protein S1 domain Cell division-ribosomal stress proteins cluster 1 T2D_unique_254197_1_254_+ FIG00000680 52 9 52 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_254198_1_423_- FIG01304818 95 16 96 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_254254_1_250_- FIG00035627 20 5 21 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_254254_279_423_- FIG00003472 19 3 20 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_254263_1_423_+ FIG00000080 29 5 30 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_254298_1_423_+ FIG00046929 14 6 17 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_254324_1_423_- FIG01260980 69 12 70 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_254340_1_423_+ FIG00021289 15 4 16 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_254346_1_423_- FIG00001469 82 13 83 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_254353_1_423_- FIG00000243 16 5 17 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_254370_285_423_+ FIG00000055 20 4 22 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_254374_1_423_- FIG00067248 31 7 33 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_254384_1_423_+ FIG00041819 30 7 31 N-acylglucosamine 2-epimerase (EC 5.1.3.8) Sialic Acid Metabolism 1.x T2D_unique_254392_1_310_- FIG00000086 51 11 51 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_254394_273_423_+ FIG00000641 8 2 9 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_254401_1_423_+ FIG00000056 37 12 38 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_254407_52_411_+ FIG00000038 20 5 22 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_254411_1_423_- FIG00002011 80 15 81 Ferric iron ABC transporter, iron-binding protein Iron acquisition in Streptococcus 1 T2D_unique_254412_1_351_+ FIG00000080 22 7 24 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_254413_1_423_- FIG00008708 59 10 60 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_254421_190_423_+ FIG00002385 8 3 9 NPQTN specific sortase B Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_254433_1_423_- FIG00000032 4 2 5 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_254438_1_324_+ FIG00018699 56 9 57 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_254446_1_423_- FIG00001550 17 7 19 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_254454_1_423_+ FIG00020897 3 2 4 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_254457_1_423_- FIG00000402 100 16 100 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_254473_1_423_+ FIG00000308 17 5 18 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_254492_1_390_- FIG00000256 8 5 9 Shikimate kinase I (EC 2.7.1.71) Chorismate Synthesis 1 T2D_unique_254494_1_244_- FIG00005283 51 9 51 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_254510_157_423_- FIG00000122 30 7 31 Aspartate carbamoyltransferase (EC 2.1.3.2) De Novo Pyrimidine Synthesis 1 T2D_unique_254515_7_423_- FIG00080955 94 14 94 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_254530_1_423_- FIG00005705 14 5 15 Ferric iron ABC transporter, ATP-binding protein Iron acquisition in Streptococcus 1 T2D_unique_254555_1_214_- FIG00003715 4 2 6 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_254567_1_423_- FIG00000156 58 12 59 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_254571_1_423_+ FIG00010262 28 7 32 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) EC699-706 1 T2D_unique_254601_1_228_- FIG00013010 39 7 41 Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_254610_1_312_+ FIG00000402 6 3 7 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_254623_280_423_+ FIG00001548 17 4 17 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_254638_20_423_- FIG00092649 60 10 61 Ribonuclease P protein component (EC 3.1.26.5) Cell Division Subsystem including YidCD 1 T2D_unique_254642_12_423_+ FIG00020185 7 4 9 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_254650_1_423_- FIG00093180 37 8 39 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_254697_1_360_+ FIG00000279 8 3 9 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_254702_1_423_+ FIG00000402 12 6 15 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_254714_1_423_+ FIG00000372 15 5 16 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_254716_1_423_- FIG00004218 13 4 14 Evolved beta-D-galactosidase transcriptional repressor Lactose utilization 1.00 T2D_unique_254740_1_423_+ FIG00000422 83 15 84 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_254752_1_423_- FIG00139192 30 10 32 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_254767_1_423_- FIG00038343 29 6 31 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_254776_1_423_+ FIG00000594 43 8 45 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_254812_1_341_+ FIG00001188 53 9 54 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_254814_1_423_+ FIG00005487 111 17 111 Glutamine amidotransferase, class-II Ammonia assimilation 1 T2D_unique_254818_1_385_+ FIG00007960 42 7 43 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_254827_1_423_- FIG00052300 24 5 25 Zn-dependent hydrolase (beta-lactamase superfamily) Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_254833_1_199_- FIG00000175 12 3 13 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_254835_1_242_- FIG01124301 4 3 6 Arsenical resistance operon repressor Arsenic resistance 1 T2D_unique_254840_1_407_+ FIG00000097 32 6 33 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_254862_1_423_- FIG00000116 12 4 13 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_254876_126_423_+ FIG00138031 7 2 9 Iron compound ABC uptake transporter permease protein Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_254895_1_319_+ FIG00000397 78 12 78 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_254898_1_423_+ FIG00046929 9 5 10 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_254905_59_423_+ FIG00002803 55 9 56 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_254923_187_423_+ FIG00059211 3 2 4 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_254926_1_273_+ FIG00001181 56 10 56 Superoxide dismutase [Cu-Zn] precursor (EC 1.15.1.1) Oxidative stress 1.2 T2D_unique_254983_1_354_+ FIG00000126 16 7 17 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_255038_1_182_+ FIG00003535 19 4 21 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_255045_181_422_+ FIG00008077 63 9 63 Putative pheromone cAM373 precursor lipoprotein CamS Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_255048_70_422_- FIG00085033 61 10 62 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_255054_1_422_+ FIG00000504 56 9 57 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_255080_1_405_+ FIG00001088 111 16 111 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_255098_119_422_- FIG00005237 14 4 15 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_255124_1_305_- FIG00126843 3 3 5 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_255149_1_346_+ FIG00521176 3 3 11 fructose response regulator of fruA and EII fructose/mannose Fructose and Mannose Inducible PTS 2 T2D_unique_255191_1_422_- FIG00000877 57 10 60 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_255194_1_389_- FIG00000243 62 11 63 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_255197_219_422_+ FIG00002992 17 4 18 L-fuculokinase (EC 2.7.1.51) L-fucose utilization 1 T2D_unique_255224_1_422_+ FIG00026918 25 7 27 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_255243_1_422_- FIG00015381 8 3 10 Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter ECF class transporters 345678 T2D_unique_255268_98_422_+ FIG00001896 25 6 26 LSU ribosomal protein L25p Ribosome LSU bacterial 9 T2D_unique_255281_1_192_+ FIG00000504 22 4 23 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_255284_1_254_+ FIG00774823 31 6 32 Conservative hypothetical protein probably involved in hydantoin, pyrimidine utilization Hydantoin metabolism 4 T2D_unique_255297_1_422_+ FIG00011423 72 12 73 Ferredoxin reductase Anaerobic respiratory reductases 3 T2D_unique_255335_1_422_+ FIG00038920 22 6 24 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_255345_1_268_- FIG00025216 7 2 8 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_255352_1_422_+ FIG00000011 34 9 35 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_255375_95_422_+ FIG01007502 17 4 18 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_255377_1_422_+ FIG00138004 38 7 42 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_255409_1_372_- FIG00001960 7 3 8 FIG001960: FtsZ-interacting protein related to cell division Cell Division Cluster 1.x T2D_unique_255458_1_422_+ FIG00067681 37 10 40 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_255462_1_252_+ FIG00000164 39 7 40 Ribosome-binding factor A Translation initiation factors bacterial 1.111 T2D_unique_255464_1_422_- FIG00002300 31 8 33 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_255470_75_422_+ FIG00005237 23 8 25 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_255475_1_422_+ FIG00011468 12 4 14 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_255493_1_422_- FIG00018457 81 13 82 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_255507_1_422_+ FIG00016110 106 16 106 Xanthine/uracil/thiamine/ascorbate permease family protein Purine Utilization 1 T2D_unique_255524_136_422_+ FIG00004078 15 4 16 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_255532_1_380_+ FIG00040528 30 7 39 Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282) Quinate degradation 3 T2D_unique_255555_1_422_- FIG00000113 98 15 98 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_255560_67_422_+ FIG00002020 14 4 15 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_255561_1_222_+ FIG00030440 47 7 48 Mercuric resistance operon regulatory protein Mercury resistance operon 1 T2D_unique_255581_1_422_+ FIG00000672 16 5 19 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_255596_1_422_- FIG00003474 16 5 18 Nucleoside permease NupC Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_255600_182_422_- FIG00001582 19 5 20 Putative Nudix hydrolase YfcD (EC 3.6.-.-) Nudix proteins (nucleoside triphosphate hydrolases) 1 T2D_unique_255607_142_422_- FIG00001188 50 8 52 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_255620_1_422_+ FIG00016514 45 13 47 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_255640_1_422_- FIG00000402 97 14 97 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_255644_1_422_- FIG01260980 114 17 116 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_255654_1_422_+ FIG00104852 7 2 8 Predicted D-lactate dehydrogenase, Fe-S protein, FAD/FMN-containing Lactate utilization 3 T2D_unique_255676_1_329_- FIG00000056 72 12 72 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_255680_1_214_- FIG01303902 5 3 7 RNA polymerase sigma-70 factor Transcription initiation, bacterial sigma factors 1 T2D_unique_255686_1_422_- FIG00006463 78 12 79 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_255714_1_422_- FIG00006463 13 5 15 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_255739_1_422_+ FIG00000370 44 11 45 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_255741_1_422_- FIG00000102 112 16 112 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_255756_190_422_- FIG00001146 56 8 56 GTP cyclohydrolase I (EC 3.5.4.16) type 2 Zinc regulated enzymes 1 T2D_unique_255757_1_422_+ FIG00004220 6 2 7 Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5) Protein degradation 1 T2D_unique_255760_192_422_- FIG00037500 17 3 18 Phage minor capsid protein Phage head and packaging 1 T2D_unique_255766_1_217_+ FIG00000290 14 3 15 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_255769_1_254_- FIG00059211 18 5 19 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_255778_1_422_+ FIG00023369 57 12 58 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_255796_1_422_+ FIG00044622 7 3 9 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_255816_1_187_- FIG00001385 9 3 10 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_255855_271_422_+ FIG00133292 5 2 6 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_255871_1_422_- FIG00000402 14 4 16 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_255879_225_422_+ FIG00002020 44 7 45 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_255885_1_422_+ FIG00000404 22 7 24 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_255895_1_422_+ FIG00001548 18 8 19 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_255902_1_306_+ FIG00019652 26 7 27 Segregation and condensation protein A Two cell division clusters relating to chromosome partitioning 1 T2D_unique_255907_59_421_- FIG00005237 9 4 10 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_255918_1_421_+ FIG00847536 12 3 13 Phage (Mu-like) virion morphogenesis protein Phage head and packaging 1 T2D_unique_255926_1_335_+ FIG00000858 22 8 23 Adenosylhomocysteinase (EC 3.3.1.1) Methionine Degradation 3 T2D_unique_255938_68_421_+ FIG00000673 101 14 101 DNA-3-methyladenine glycosylase (EC 3.2.2.20) DNA Repair Base Excision 4 T2D_unique_255944_290_421_+ FIG01007502 6 2 7 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_255974_1_421_- FIG01583289 15 4 18 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_255976_1_421_+ FIG00016663 86 15 86 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_256034_143_421_- FIG00006474 4 5 5 PTS system, galactose-specific IIA component (EC 2.7.1.69) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_256049_139_421_+ FIG00719736 4 2 5 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_256065_1_421_+ FIG00000102 5 3 6 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_256099_1_172_- FIG00003530 9 3 10 Sucrose operon repressor ScrR, LacI family Sucrose utilization 1.1x T2D_unique_256103_1_235_- FIG00003520 9 3 10 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_256114_1_421_- FIG00135554 6 2 7 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_256148_44_421_- FIG00103661 98 14 98 Transcriptional regulator, MerR family, near polyamine transporter Polyamine Metabolism 2 T2D_unique_256180_1_403_+ FIG00023943 108 16 108 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_256184_6_421_+ FIG00001712 23 8 25 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_256191_1_421_- FIG00001518 102 16 102 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_256195_1_421_+ FIG00001198 3 2 4 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_256197_41_421_- FIG00001044 95 13 95 Respiratory nitrate reductase alpha chain (EC 1.7.99.4) Nitrate and nitrite ammonification 1 T2D_unique_256205_274_421_+ FIG01367215 12 3 13 predicted xylose isomerase Xylose utilization 1 T2D_unique_256222_73_421_- FIG00000402 10 3 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_256259_1_421_- FIG00000986 51 11 53 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_256262_1_421_+ FIG00000289 4 2 6 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_256267_1_421_+ FIG00000025 58 10 59 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_256298_1_421_+ FIG00136922 5 2 10 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_256326_1_258_+ FIG00139192 20 6 20 NAD-reducing hydrogenase subunit HoxF (EC 1.12.1.2) Hydrogenases 2 T2D_unique_256327_1_377_+ FIG00000118 11 3 13 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_256329_1_222_- FIG00000279 12 4 13 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_256332_1_421_- FIG00048839 8 2 10 Alpha-N-acetylglucosaminidase (EC 3.2.1.50) Chitin and N-acetylglucosamine utilization 2 T2D_unique_256333_1_179_- FIG00018369 23 4 24 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_256346_1_308_- FIG00001676 12 3 13 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_256370_134_421_- FIG00028694 63 10 63 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_256387_1_421_- FIG00001264 6 4 8 Phosphatidylserine decarboxylase (EC 4.1.1.65) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_256399_1_421_- FIG00000402 20 5 22 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_256409_222_421_+ FIG00615494 27 6 28 DNA-binding protein HU DNA structural proteins, bacterial 1.1100 T2D_unique_256418_1_421_+ FIG00013638 7 4 8 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_256426_1_406_+ FIG00001094 51 11 53 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_256442_1_421_+ FIG00104852 127 17 127 Predicted D-lactate dehydrogenase, Fe-S protein, FAD/FMN-containing Lactate utilization 3 T2D_unique_256443_92_421_+ FIG00004170 89 13 89 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_256461_34_421_- FIG00000985 4 3 6 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_256498_1_421_- FIG00096593 125 17 125 Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_256499_1_421_- FIG00011906 11 4 13 LysR family transcriptional regulator STM2281 DNA-binding regulatory proteins, strays 1 T2D_unique_256502_1_421_+ FIG00000863 118 17 118 L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) Cobalamin synthesis 2 T2D_unique_256504_1_358_- FIG00000822 20 4 21 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_256509_1_421_+ FIG01290653 75 14 75 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_256522_1_421_+ FIG00000584 6 2 8 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_256543_1_410_+ FIG00000089 79 13 80 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_256547_1_225_+ FIG00047414 37 7 38 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_256547_230_421_+ FIG00000013 9 2 10 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_256548_1_421_- FIG00000510 4 3 6 SOS-response repressor and protease LexA (EC 3.4.21.88) DNA repair, bacterial UmuCD system 3 T2D_unique_256562_1_411_+ FIG00051439 31 9 34 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_256570_1_421_+ FIG01260980 15 5 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_256574_1_151_- FIG00380575 29 5 29 Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12) Peptide methionine sulfoxide reductase 1 T2D_unique_256578_1_421_+ FIG00000356 33 8 35 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_256583_1_421_- FIG00001088 4 2 6 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_256621_1_345_+ FIG00149566 5 3 6 Xanthine dehydrogenase iron-sulfur subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_256651_1_421_- FIG01954097 80 13 80 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_256653_1_421_- FIG00001522 15 5 16 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_256663_1_421_- FIG00138209 36 10 38 Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_256666_1_421_+ FIG00035175 34 7 35 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_256668_9_421_- FIG00008490 103 16 103 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_256693_1_292_+ FIG00003460 10 3 11 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_256726_1_421_- FIG01260980 6 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_256781_1_421_+ FIG00000962 45 8 46 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_256789_1_421_+ FIG00003174 7 4 8 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_256800_1_421_+ FIG00093180 3 2 6 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_256802_84_421_+ FIG00017000 79 11 80 Programmed cell death toxin MazF MazEF toxin-antitoxing (programmed cell death) system 1 T2D_unique_256820_1_421_- FIG00026918 26 7 27 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_256827_229_421_+ FIG00003672 7 2 8 Stage III sporulation protein AA Sporulation Cluster III A 1.x T2D_unique_256828_1_421_- FIG00008490 29 6 31 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_256829_1_421_+ FIG00046358 117 17 117 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_256876_1_420_+ FIG00009628 28 7 30 Programmed cell death toxin YdcE Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_256879_1_420_+ FIG00000117 47 8 48 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_256889_152_420_- FIG00000402 11 4 13 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_256892_1_230_+ FIG00000210 7 2 9 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_256934_1_420_- FIG01260980 108 15 108 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_256942_1_339_- FIG00000219 43 8 44 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_256962_1_404_+ FIG00000343 17 4 18 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_257011_1_420_- FIG00132717 86 15 87 ATP-dependent protease La (EC 3.4.21.53) Type II Proteasome bacterial 1 T2D_unique_257057_1_420_+ FIG00006151 26 8 28 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_257062_1_395_+ FIG00002968 11 2 12 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_257063_1_420_+ FIG00000504 50 9 51 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_257068_1_146_+ FIG00028694 18 4 20 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_257073_1_397_+ FIG00945384 40 6 41 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_257081_56_420_+ FIG00134135 15 4 16 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_257082_100_420_+ FIG00001469 73 11 73 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_257122_212_420_+ FIG00000584 6 2 7 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_257141_1_285_- FIG00000408 5 5 6 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_257172_1_420_+ FIG00000146 48 11 49 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_257205_45_420_+ FIG00002026 26 6 27 Nucleotidase YfbR, HD superfamily Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_257238_232_420_+ FIG00001672 38 7 38 N-acetylglucosamine kinase of eukaryotic type (EC 2.7.1.59) Chitin and N-acetylglucosamine utilization 2 T2D_unique_257272_1_420_+ FIG00745599 36 7 37 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_257300_19_420_- FIG00049433 25 6 27 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_257345_1_420_+ FIG00000076 29 9 31 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_257351_1_420_+ FIG00002541 103 16 104 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_257373_161_420_- FIG00000422 28 6 29 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_257378_1_383_- FIG00000610 8 3 9 Flagellar motor switch protein FliG Bacterial Chemotaxis 9 T2D_unique_257385_1_420_- FIG00002803 6 4 10 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_257398_1_420_- FIG00002541 62 13 63 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_257414_1_420_- FIG00044622 51 10 52 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_257416_1_272_+ FIG00003465 6 4 8 Outer membrane protein A precursor Osmoregulation 1 T2D_unique_257450_84_420_- FIG00001904 79 11 80 Outer surface protein of unknown function, cellobiose operon Beta-Glucoside Metabolism 2.bc T2D_unique_257453_1_420_- FIG00000402 23 5 25 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_257463_1_372_+ FIG00000933 69 12 69 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) Cobalamin synthesis 2 T2D_unique_257487_1_420_+ FIG00001548 9 3 11 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_257499_134_420_+ FIG00000522 13 4 15 Phosphate acetyltransferase (EC 2.3.1.8) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_257518_234_420_- FIG00005727 14 4 16 Type III restriction-modification system methylation subunit (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_257520_104_420_+ FIG00002049 8 4 9 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_257526_1_420_+ FIG00007941 21 4 22 ABC transporter ATP-binding protein uup CBSS-393121.3.peg.2760 1 T2D_unique_257529_1_375_+ FIG00000482 10 3 12 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_257542_1_263_- FIG00028476 5 4 8 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_257548_1_420_- FIG00001522 83 14 85 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_257565_122_420_+ FIG00050854 62 10 62 Tricarboxylate transport protein TctC Tricarboxylate transport system 1.x T2D_unique_257597_1_420_- FIG00136692 92 14 93 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_257605_1_420_+ FIG00000350 87 14 88 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_257667_1_420_+ FIG00011537 59 9 61 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_257716_248_420_+ FIG00037240 8 3 8 Alpha-N-arabinofuranosidase 2 (EC 3.2.1.55) L-Arabinose utilization 1 T2D_unique_257736_1_419_- FIG00018699 97 16 98 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_257740_1_419_- FIG00000210 13 3 18 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_257779_1_419_- FIG00018396 29 6 30 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_257814_1_419_+ FIG01260980 16 5 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_257825_1_189_+ FIG00340292 7 2 8 Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter ECF class transporters 345678 T2D_unique_257833_1_383_+ FIG00051957 19 5 20 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_257834_88_419_- FIG00000380 34 7 35 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_257859_1_149_- FIG00016514 36 5 36 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_257861_1_419_+ FIG00000102 8 2 10 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_257873_14_419_+ FIG00000056 75 13 77 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_257874_1_419_- FIG00000107 49 8 51 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_257936_1_337_+ FIG00000040 72 12 74 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_257939_1_419_- FIG01954097 6 6 8 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_257973_1_264_+ FIG00000309 68 10 68 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_257975_1_419_+ FIG00000121 13 5 21 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_258024_1_215_+ FIG00000212 10 3 12 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_258026_1_419_+ FIG00000962 114 17 114 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_258030_104_419_+ FIG00001550 11 4 16 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_258036_123_419_- FIG00134486 23 5 23 Replicative DNA helicase (EC 3.6.1.-) [SA14-24] CBSS-262719.3.peg.410 1 T2D_unique_258045_224_419_- FIG00000578 24 5 26 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_258061_1_419_+ FIG00000309 9 4 10 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_258062_1_419_+ FIG00000043 39 9 40 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_258086_1_419_- FIG00846773 27 6 28 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_258091_199_419_+ FIG01260980 6 4 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_258104_1_419_- FIG00515041 8 4 11 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Alkanesulfonate assimilation 9.? T2D_unique_258108_1_419_+ FIG00049915 31 9 33 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_258118_1_419_+ FIG00000380 110 16 110 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_258133_1_419_+ FIG00047414 17 3 18 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_258135_1_419_- FIG00229199 8 5 10 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_258155_1_191_- FIG00003472 7 5 8 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_258212_215_419_+ FIG00000320 3 2 4 Ubiquinone biosynthesis monooxygenase UbiB Ubiquinone Biosynthesis 2.x T2D_unique_258218_1_419_+ FIG00000812 42 10 44 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_258225_1_419_- FIG00001882 13 6 17 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_258226_106_419_+ FIG00000606 58 10 60 Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_258248_66_419_+ FIG00002354 32 6 37 4-keto-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) aminotransferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_258251_1_419_+ FIG00554193 114 17 114 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_258255_1_419_- FIG00038456 80 14 81 Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_258273_1_270_- FIG00000202 29 8 29 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_258281_1_306_- FIG00136193 48 9 48 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_unique_258295_1_419_- FIG00001548 34 8 47 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_258303_144_419_+ FIG00000210 71 11 71 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_258304_1_324_- FIG00077620 54 10 55 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_258316_1_419_+ FIG00000356 12 4 13 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_258326_1_419_- FIG01261528 13 4 14 Na+/H+ antiporter NhaD type Na(+) H(+) antiporter 1 T2D_unique_258331_210_419_+ FIG00000367 4 2 5 ADP-ribose pyrophosphatase (EC 3.6.1.13) NAD and NADP cofactor biosynthesis global E T2D_unique_258337_1_419_+ FIG00041382 97 15 97 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_258340_1_419_+ FIG00140898 88 16 89 periplasmic fructose-binding protein component of signal transduction system LevT Fructose and Mannose Inducible PTS 2 T2D_unique_258365_1_320_- FIG00002376 57 8 58 Galactose-6-phosphate isomerase, LacB subunit (EC 5.3.1.26) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_258366_1_419_+ FIG00005237 61 10 63 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_258367_102_419_- FIG00006463 65 11 66 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_258406_1_419_+ FIG00001088 74 14 75 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_258407_1_419_+ FIG00135554 38 10 40 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_258422_158_419_- FIG00229386 17 5 19 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_258428_1_419_- FIG00000973 8 3 13 RNA polymerase sigma factor RpoE Transcription initiation, bacterial sigma factors 1 T2D_unique_258449_29_419_- FIG00001653 95 15 95 Fructokinase (EC 2.7.1.4) Fructose utilization 1 T2D_unique_258481_1_419_+ FIG00085033 18 5 20 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_258484_1_419_+ FIG00001036 106 16 107 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_258536_15_419_- FIG00763261 11 5 13 DNA replication protein DnaC DNA-replication 4 T2D_unique_258560_1_238_+ FIG00058830 44 7 45 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_258567_1_419_+ FIG00000121 15 4 16 Seryl-tRNA synthetase (EC 6.1.1.11) tRNA aminoacylation, Ser 1.00 T2D_unique_258569_1_419_+ FIG00005172 34 10 36 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_258588_1_419_- FIG00000087 51 9 67 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_258598_222_419_- FIG00000095 12 4 13 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_258609_1_249_- FIG01260980 26 7 28 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_258612_133_354_- FIG00001065 9 3 9 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_258619_1_418_+ FIG00000873 34 8 35 Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_unique_258622_1_418_- FIG00020613 95 15 96 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_258628_98_418_+ FIG00000402 83 12 83 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_258632_72_418_+ FIG00001188 32 7 33 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_258634_1_259_- FIG00138908 60 10 60 Flavin reductase (EC 1.5.1.30) Hemin transport system 1 T2D_unique_258635_1_418_- FIG00000107 76 14 77 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_258666_1_372_+ FIG00000405 104 15 104 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_258719_1_283_+ FIG00018699 15 4 16 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_258731_54_418_- FIG00002251 4 3 6 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_258755_1_418_+ FIG00003387 9 2 11 ABC transporter multidrug efflux pump, fused ATP-binding domains ATP-dependent efflux pump transporter Ybh 1 T2D_unique_258770_1_418_- FIG00012746 29 9 30 Glycine betaine transporter OpuD Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_258783_1_418_+ FIG00138258 13 4 14 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_258787_1_418_+ FIG00003535 108 16 108 Hydrolase (HAD superfamily) in cluster with DUF1447 Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_258849_153_418_+ FIG00080231 57 10 58 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_258864_1_418_- FIG00002574 50 9 51 2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37) Phosphonate metabolism 1 T2D_unique_258873_1_418_+ FIG00451095 101 14 104 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_258877_1_418_+ FIG00007957 23 7 26 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_258879_1_418_+ FIG00001469 120 17 120 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_258897_1_406_+ FIG00000290 10 5 11 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_258898_1_292_+ FIG00000132 27 5 29 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_258907_1_418_- FIG00000756 23 6 24 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_unique_258945_1_324_- FIG00001076 71 12 71 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_258952_63_418_+ FIG00000986 67 12 68 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_258963_1_418_- FIG01260980 7 2 8 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_258972_1_418_+ FIG00126843 35 7 36 Periplasmic [Fe] hydrogenase (EC 1.12.7.2) Hydrogenases 2 T2D_unique_258975_1_418_+ FIG00138258 28 7 30 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_259000_1_418_+ FIG00002914 10 7 13 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_259025_1_418_+ FIG00000116 5 3 6 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_259028_40_418_- FIG00711303 90 15 90 Guanine-hypoxanthine permease Purine Utilization 1 T2D_unique_259030_1_418_+ FIG00000132 73 15 74 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_259057_1_418_- FIG00088996 3 2 5 Substrate-specific component PanT of predicted pantothenate ECF transporter ECF class transporters 345678 T2D_unique_259098_112_418_+ FIG00001020 12 4 13 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_259101_141_418_- FIG00000081 6 2 8 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_259106_1_418_+ FIG00001530 10 4 11 Deblocking aminopeptidase (EC 3.4.11.-) Protein degradation 1 T2D_unique_259120_1_418_- FIG00000402 13 5 14 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_259128_1_184_- FIG00000721 50 7 51 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_259145_44_418_+ FIG00846773 6 2 9 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_259155_1_418_+ FIG00000040 80 12 81 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_259156_1_418_- FIG00031250 21 6 22 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_259180_1_418_+ FIG01304818 14 3 15 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_259192_1_326_+ FIG00052730 92 13 92 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_259205_1_320_+ FIG00019251 78 12 78 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_259234_1_407_+ FIG00000308 62 11 79 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_259236_1_418_- FIG00093180 8 2 10 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_259245_1_418_- FIG00055715 7 3 9 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_259249_1_418_+ FIG00049433 82 15 83 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_259255_1_418_+ FIG00000402 3 2 5 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_259265_1_379_+ FIG00000358 59 11 60 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_259353_1_418_+ FIG00000111 16 5 24 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_259355_1_418_- FIG00000011 13 5 15 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_259364_1_157_+ FIG00038814 4 2 5 RNA polymerase sigma factor RpoD Transcription initiation, bacterial sigma factors 1 T2D_unique_259370_1_418_+ FIG00138182 3 3 5 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_259383_1_418_+ FIG00006151 9 4 13 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_259387_1_418_- FIG00006128 13 5 15 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_259390_102_418_+ FIG00000245 91 12 91 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_259396_1_418_- FIG00000176 102 16 103 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_259429_1_418_- FIG00000446 65 11 73 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_259435_1_306_- FIG00000738 80 12 80 Phosphopentomutase (EC 5.4.2.7) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_259454_1_313_- FIG00000895 34 7 35 Alanine dehydrogenase (EC 1.4.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_259460_197_418_- FIG00000343 3 2 4 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_259479_1_276_- FIG00001440 21 6 23 L-serine dehydratase, alpha subunit (EC 4.3.1.17) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_259481_155_418_+ FIG00002320 46 9 47 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_unique_259511_1_365_+ FIG00113730 32 6 38 Alkanesulfonate monooxygenase (EC 1.14.14.5) Alkanesulfonates Utilization 20 T2D_unique_259517_1_317_- FIG00001401 6 3 8 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_259519_1_418_- FIG00066575 5 3 6 Exopolyphosphatase (EC 3.6.1.11) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_259530_107_417_+ FIG00001106 29 8 30 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_259553_1_417_- FIG00009564 105 16 105 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_259565_1_417_+ FIG00000437 16 4 18 Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_259572_1_417_- FIG00046929 51 9 57 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_259591_1_417_+ FIG00945384 7 3 10 Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_259610_1_417_+ FIG00028203 25 8 29 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_259632_1_358_+ FIG00077620 13 4 15 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_259640_144_417_- FIG00013626 7 4 9 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_259650_1_417_- FIG00000283 16 3 17 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_259665_1_417_+ FIG00000113 38 9 39 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_259677_1_417_+ FIG00054459 57 11 58 Phosphoglycerate kinase (EC 2.7.2.3) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_259687_1_417_+ FIG01260980 10 5 12 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_259701_1_417_+ FIG00018369 26 8 28 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_259711_1_417_- FIG00001166 68 13 68 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_259739_1_417_+ FIG00001719 29 7 32 Co-activator of prophage gene expression IbrB IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_259742_58_417_+ 24 8 51 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_259765_1_324_+ FIG00135554 19 4 20 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_259769_1_223_- FIG00000188 4 3 6 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_259794_1_417_+ FIG00000709 8 4 9 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) Periplasmic disulfide interchange 1 T2D_unique_259797_1_417_+ FIG00005022 34 9 35 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_259801_1_417_- FIG00002864 9 4 10 [Protein-PII] uridylyltransferase (EC 2.7.7.59) CBSS-312309.3.peg.1965 1 T2D_unique_259802_1_417_- FIG00133196 8 5 10 L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-) L-ascorbate utilization (and related gene clusters) 29 T2D_unique_259814_1_318_- FIG00000423 12 2 13 Dethiobiotin synthetase (EC 6.3.3.3) Biotin biosynthesis 1X T2D_unique_259815_1_417_+ FIG00129130 44 10 46 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_259816_1_417_+ FIG00000080 21 7 23 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_259830_250_417_- FIG00451095 43 6 43 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_259839_105_417_+ FIG00000370 7 3 10 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_259844_133_417_- FIG00000847 67 10 67 Allophanate hydrolase 2 subunit 1 (EC 3.5.1.54) EC699-706 1 T2D_unique_259850_1_417_+ FIG00006128 113 16 113 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_259851_1_417_+ FIG00000176 51 11 53 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_259854_20_417_+ FIG00005647 16 5 18 Chemotaxis protein CheD Bacterial Chemotaxis 9 T2D_unique_259859_122_417_+ FIG00000356 37 8 39 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_259869_1_417_- FIG00000402 58 12 62 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_259877_1_417_+ FIG00007957 86 15 86 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_259900_1_411_+ FIG00000130 25 6 27 Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_259905_1_363_- FIG00846773 15 3 16 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_259913_97_417_- FIG00561498 10 3 11 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_259936_1_417_+ FIG00001469 48 10 50 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_259947_1_417_- FIG00038920 15 4 16 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_259970_1_338_+ FIG00018865 15 5 17 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_259972_1_417_+ FIG00000842 48 11 50 D-lactate dehydrogenase (EC 1.1.1.28) Fermentations: Mixed acid 1 T2D_unique_259975_1_417_- FIG00001036 42 9 43 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_259976_191_417_+ FIG00001976 9 4 11 Glutamyl-tRNA(Gln) synthetase (EC 6.1.1.24) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_259979_25_417_+ FIG00000601 39 10 41 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) Histidine Biosynthesis 1 T2D_unique_259993_1_417_+ FIG00132801 71 13 71 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_260015_1_417_+ FIG00000595 74 12 76 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_260031_1_309_+ FIG00135025 4 3 5 Aldose 1-epimerase (EC 5.1.3.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_260058_1_417_- FIG00001298 9 4 10 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_260064_68_417_+ FIG00006953 51 9 52 Heteropolysaccharide repeat unit export protein Rhamnose containing glycans 4.1 T2D_unique_260071_1_417_- FIG00000116 100 16 100 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_260082_2_417_- FIG00037431 4 3 7 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_260116_1_417_- FIG00000187 61 12 62 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_260143_1_247_- FIG00028461 67 9 67 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_260182_1_417_- FIG00001882 100 16 101 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_260194_128_417_+ FIG00006336 79 11 79 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_260204_1_417_+ FIG00009682 67 11 68 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_260217_1_417_+ FIG00008708 88 15 88 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_260227_1_417_- FIG00001168 14 4 15 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_260230_1_294_+ FIG00019415 70 11 72 Putative activity regulator of membrane protease YbbK CBSS-316057.3.peg.659 1 T2D_unique_260287_1_417_- FIG00000392 47 11 49 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_260298_1_173_- FIG00000132 19 4 20 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_260299_1_417_+ FIG00000372 12 5 13 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_260303_1_417_- FIG00000146 13 5 14 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_260334_15_417_- FIG00108342 15 5 17 tRNA-i(6)A37 methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_260377_1_417_+ FIG00000308 111 16 111 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_260386_1_417_+ FIG00000212 32 8 33 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_260395_1_407_+ FIG00001803 17 5 21 Polyferredoxin NapH (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_260440_1_416_- FIG00000011 7 4 8 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_260458_1_416_- FIG00006691 5 2 8 Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_260470_1_152_+ FIG00134342 14 3 15 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_260470_207_416_- FIG00000338 8 3 10 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_260537_27_329_+ FIG00061832 40 6 41 Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) Sialic Acid Metabolism 1.x T2D_unique_260550_1_416_- FIG01260980 42 10 43 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_260552_1_416_+ FIG00034973 26 7 27 2-dehydropantoate 2-reductase (EC 1.1.1.169) Coenzyme A Biosynthesis A.191 T2D_unique_260559_5_298_+ FIG00059413 16 3 17 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), ADP-binding subunit DhaL Dihydroxyacetone kinases 3 T2D_unique_260565_1_416_+ FIG00000595 19 5 20 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_260572_1_416_+ FIG00067681 63 11 71 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_260614_1_416_- FIG00135546 37 8 38 Predicted rhamnogalacturonan lyase in rhamnose utilization cluster L-rhamnose utilization 1 T2D_unique_260620_1_416_- FIG00041382 67 11 68 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_260643_1_416_- FIG01260980 114 17 114 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_260649_1_416_- FIG01960451 76 13 77 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_260670_1_416_- FIG00134135 51 8 52 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_260673_1_416_+ FIG00018699 24 8 26 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_260679_106_416_+ FIG00000173 40 9 42 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) De Novo Pyrimidine Synthesis 1 T2D_unique_260680_209_416_+ FIG00013626 14 3 15 N-Acetyl-D-glucosamine ABC transport system, sugar-binding protein Chitin and N-acetylglucosamine utilization 2 T2D_unique_260687_136_416_- FIG00000425 27 5 30 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_260714_232_416_+ FIG00000070 18 5 19 Chaperone protein DnaJ Protein chaperones 2.0 T2D_unique_260725_1_416_- FIG00035175 54 11 55 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_260733_8_416_- FIG00000402 23 7 24 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_260761_74_416_+ FIG00017761 4 2 6 Biopolymer transport protein ExbD/TolR Ton and Tol transport systems 2 T2D_unique_260773_1_288_- FIG00000189 70 11 70 LSU ribosomal protein L27p CBSS-176279.3.peg.868 1.x T2D_unique_260779_1_416_- FIG00000001 62 10 63 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_260793_1_416_+ FIG00006336 62 9 64 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_260800_1_416_- FIG00004220 8 3 10 Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5) Protein degradation 1 T2D_unique_260816_1_416_+ FIG00001505 19 7 21 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_260834_1_416_+ FIG00132994 7 3 8 Glycerol dehydrogenase (EC 1.1.1.6) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_260855_1_374_- FIG00018536 34 8 36 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_260861_1_416_- FIG00093180 11 4 15 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_260885_62_416_- FIG01954097 7 4 10 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_260961_140_416_+ FIG00000111 8 2 11 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_260968_136_416_- FIG00008591 22 4 23 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_260971_1_416_- FIG00000287 83 15 84 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_260977_1_272_- FIG00138960 58 10 58 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_unique_261012_1_189_+ FIG00001059 27 5 28 TolA protein Ton and Tol transport systems 2 T2D_unique_261012_280_416_+ FIG00000114 35 5 35 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_261020_1_416_+ FIG00000113 35 11 36 Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_261052_1_416_- FIG00040528 12 4 13 Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282) Quinate degradation 3 T2D_unique_261054_1_416_+ FIG00000147 31 8 32 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_261062_1_416_+ FIG00000279 25 8 29 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_261065_1_221_+ FIG00003555 3 2 5 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_261066_1_416_+ FIG01296685 65 11 65 ATPase component STY3232 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_261085_1_360_+ FIG00000387 36 8 37 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_261086_1_294_+ FIG00000298 27 6 28 GTP-binding protein EngB Universal GTPases 2 T2D_unique_261089_136_416_+ FIG00004730 60 9 62 YbbM seven transmembrane helix protein Broadly distributed proteins not in subsystems 1 T2D_unique_261102_1_416_+ FIG00229199 81 14 81 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_261110_1_232_- FIG00000441 15 4 17 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_261123_1_279_- FIG00031250 54 10 55 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_261145_6_416_+ FIG01266244 60 12 64 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_261163_1_416_- FIG00006463 78 14 80 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_261166_1_416_+ FIG01260980 96 16 96 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_261171_1_395_+ FIG00000504 14 3 15 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_261176_1_416_- FIG01260980 98 16 99 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_261200_1_183_+ FIG00047414 6 2 7 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_261201_37_416_+ FIG01276220 48 9 49 Lysyl endopeptidase (EC 3.4.21.50) EC 3.4.21.- Serine endopeptidase 1 T2D_unique_261217_1_416_- FIG00001583 27 7 29 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_261225_1_416_- FIG00000224 72 13 73 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_261228_1_416_- FIG00000422 29 8 30 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_261257_1_146_+ FIG00009996 23 4 23 Alkaline phosphatase synthesis transcriptional regulatory protein PhoP High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_261268_1_416_- FIG00000401 11 3 13 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_261313_1_416_- FIG00003474 101 16 101 Nucleoside permease NupC Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_261332_1_137_+ FIG00008273 8 2 9 N-acetylneuraminate synthase (EC 2.5.1.56) Sialic Acid Metabolism 1.x T2D_unique_261349_1_416_- FIG00000793 101 15 101 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_261378_1_415_+ FIG01546819 19 4 22 TPP-requiring enzyme co-localized with putative O-antigen rfb gene cluster Acetoin, butanediol metabolism 5 T2D_unique_261383_1_415_- FIG00000290 15 5 16 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_261392_88_415_+ FIG01260980 3 3 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_261396_1_338_- FIG00002410 14 4 16 Recombinational DNA repair protein RecT (prophage associated) DNA repair, bacterial 3 T2D_unique_261398_29_256_- FIG00001229 7 2 8 Ribosome hibernation protein YhbH Ribosome activity modulation 1 T2D_unique_261401_1_415_+ FIG00000383 7 2 9 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_261454_1_415_+ FIG00093180 5 2 6 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_261482_1_415_+ FIG00003845 79 13 80 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_261533_1_415_- FIG00080955 6 3 8 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_261563_1_415_+ FIG00036983 119 16 119 Metallo-beta-lactamase family protein, RNA-specific Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_261575_174_415_- FIG00021347 3 2 4 Death on curing protein, Doc toxin Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_261581_274_415_+ FIG00055715 26 5 26 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_261593_167_415_- FIG00093180 35 5 36 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_261621_80_415_- FIG01260980 18 7 45 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_261639_1_415_+ FIG00000287 33 6 37 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_261656_1_415_+ FIG00014000 12 4 16 ATP-dependent Clp protease ATP-binding subunit ClpA Proteolysis in bacteria, ATP-dependent 3 T2D_unique_261662_1_227_- FIG00000584 6 2 7 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_261662_260_415_- FIG00000095 17 4 18 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_261677_1_341_- FIG01954554 7 2 8 Peptidyl-prolyl cis-trans isomerase ppiB (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_261683_1_415_- FIG00001401 113 16 114 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_261760_1_415_- FIG01958907 12 3 13 Phage terminase Phage head and packaging 1 T2D_unique_261778_1_391_+ FIG00002761 4 2 6 DedA protein Uptake of selenate and selenite 1.1 T2D_unique_261782_1_415_+ FIG00000423 24 8 26 Dethiobiotin synthetase (EC 6.3.3.3) Biotin biosynthesis 1X T2D_unique_261786_93_415_+ FIG00132548 40 10 41 Thiol peroxidase, Bcp-type (EC 1.11.1.15) CBSS-316057.3.peg.3521 1 T2D_unique_261792_1_415_+ FIG00000402 8 5 11 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_261799_87_415_- FIG00000283 14 5 16 DNA repair protein RadA DNA repair, bacterial 3 T2D_unique_261801_1_415_- FIG00002300 51 11 52 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_261833_267_415_+ FIG00075970 10 3 11 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_261837_1_415_+ FIG00000352 8 2 14 Holliday junction DNA helicase RuvB DNA-replication 4 T2D_unique_261847_1_415_+ FIG01260980 39 11 41 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_261854_1_415_+ FIG00000578 20 6 21 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_261867_1_415_+ FIG00459778 110 16 111 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_261870_96_415_+ FIG00000146 55 9 56 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_261871_1_391_- FIG00001616 94 13 94 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_261879_1_346_+ FIG00000782 11 3 12 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_261915_1_415_- FIG00000527 64 13 66 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_261925_1_284_- FIG00002689 22 6 24 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_261939_1_415_- FIG00001088 30 8 31 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_261968_1_161_+ FIG00000234 16 4 18 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_261977_1_415_- FIG00001712 27 7 29 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_261978_1_360_+ FIG00000015 9 5 18 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_262008_1_415_+ FIG00059211 107 15 107 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_262038_29_415_- FIG00059426 27 7 28 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_262043_1_415_+ FIG00041038 37 10 59 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_262045_186_415_- FIG00000210 3 2 4 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_262046_1_415_- FIG00001106 60 12 61 Homoserine O-succinyltransferase (EC 2.3.1.46) Methionine Biosynthesis 8 T2D_unique_262121_1_415_+ FIG00085033 17 5 18 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) Peptidoglycan Biosynthesis 1.9 T2D_unique_262137_1_415_+ FIG00135554 38 9 39 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_262138_1_415_+ FIG00052730 112 16 112 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_262187_73_415_- FIG00000001 26 7 28 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_262222_1_133_- FIG00001465 29 5 29 Ferredoxin-type protein NapF (periplasmic nitrate reductase) Nitrate and nitrite ammonification 1 T2D_unique_262226_1_222_- FIG01260980 50 8 51 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_262231_38_274_- FIG00002328 4 2 7 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_262232_1_415_- FIG00000032 13 4 15 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_262247_1_408_+ FIG00000131 46 10 47 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_262248_1_402_- FIG00001824 16 4 18 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_262252_1_415_- FIG00004078 50 8 52 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_262268_8_415_- FIG00000261 108 15 108 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) Coenzyme A Biosynthesis A.191 T2D_unique_262292_1_414_- FIG00041038 29 7 31 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_262305_1_414_- FIG00014596 10 3 12 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_262308_280_414_+ FIG00001670 15 3 15 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_262310_1_414_+ FIG00006151 9 3 11 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_262316_1_414_- FIG00049433 14 6 15 Periplasmic [Fe] hydrogenase large subunit (EC 1.12.7.2) Hydrogenases 2 T2D_unique_262349_1_414_- FIG00554193 8 5 10 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_262351_1_414_+ FIG00001067 7 4 16 Rubrerythrin Oxidative stress 1.2 T2D_unique_262372_1_414_+ FIG00002020 33 9 35 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_262407_1_387_+ FIG00000134 50 9 51 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_262411_1_414_- FIG00005559 66 10 67 L-proline glycine betaine ABC transport system permease protein ProW (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_262427_109_414_+ FIG01955782 40 7 41 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_262428_1_414_- FIG00009149 100 14 101 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_262434_47_414_- FIG00001469 9 4 11 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_262474_1_414_+ FIG00001175 15 4 17 Thiamin pyrophosphokinase (EC 2.7.6.2) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_262478_1_414_+ FIG00561498 33 6 35 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_262491_1_239_+ FIG00001819 17 4 18 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_262491_258_414_+ FIG00000202 15 3 16 Ribosome recycling factor Translation termination factors bacterial 1.13 T2D_unique_262494_187_414_- FIG00002344 4 2 5 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_262547_1_414_- FIG00046929 5 3 7 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_262562_1_414_- FIG00000539 15 4 17 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_262600_267_414_+ FIG00000146 6 3 7 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_262602_1_377_+ FIG00002414 25 7 26 Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) Cobalamin synthesis 2 T2D_unique_262625_1_233_+ FIG00001080 12 4 20 Membrane fusion component of tripartite multidrug resistance system Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 1 T2D_unique_262633_1_414_+ FIG00025086 68 12 68 Xanthine permease Purine Utilization 1 T2D_unique_262644_1_414_+ FIG00017431 107 16 107 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_unique_262649_1_414_+ FIG00004021 37 8 38 RNA polymerase sporulation specific sigma factor SigK Transcription initiation, bacterial sigma factors 1 T2D_unique_262651_1_198_+ FIG00018369 19 4 20 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_262660_1_414_+ FIG00000025 4 3 5 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_262690_1_414_- FIG00000571 84 15 85 Signal transduction histidine kinase CheA (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_unique_262697_1_414_- FIG00001719 25 7 28 Co-activator of prophage gene expression IbrB IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_262699_1_414_+ FIG00003433 10 2 11 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_262701_1_414_+ FIG00002541 10 3 12 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_262711_1_414_+ FIG00002049 11 3 13 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_262718_1_414_- FIG00000337 95 16 95 Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) Serine-glyoxylate cycle 1 T2D_unique_262725_132_414_+ FIG00007514 23 4 24 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_262732_1_414_- FIG00020613 39 8 41 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_262735_268_414_+ FIG00010738 9 2 10 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_262746_134_414_+ FIG00561498 36 7 37 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_262747_1_414_- FIG00000527 97 14 98 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_262748_1_390_+ FIG00000241 41 9 42 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_262761_129_414_+ FIG00139491 15 4 16 NAD-reducing hydrogenase subunit HoxE (EC 1.12.1.2) Hydrogenases 2 T2D_unique_262770_1_414_+ FIG00000764 11 2 12 Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) Cobalamin synthesis 2 T2D_unique_262788_1_414_+ FIG00093180 4 3 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_262805_1_238_- FIG00007316 34 7 36 Glycerol-3-phosphate ABC transporter, permease protein UgpA (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_262805_248_414_- FIG01955932 35 6 36 Maltose/maltodextrin transport ATP-binding protein MalK (EC 3.6.3.19) Maltose and Maltodextrin Utilization 1.x T2D_unique_262815_166_414_+ FIG00000149 22 5 24 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_262825_1_349_+ FIG00000175 9 2 10 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_262834_225_414_+ FIG00010738 6 2 8 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_262872_1_192_+ FIG00018865 6 3 7 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_262873_190_414_- FIG01260980 17 4 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_262898_1_414_+ FIG00021644 25 6 27 Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_262903_1_414_- FIG00000877 58 11 59 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_262915_1_414_- FIG00006764 39 8 40 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_262936_61_414_+ FIG00001065 89 13 89 Glucokinase (EC 2.7.1.2) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_262954_1_414_+ FIG00000721 3 3 5 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_262961_1_414_+ FIG00018699 18 7 19 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_262983_1_169_- FIG00000131 4 2 5 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_262984_1_164_- FIG00000445 19 3 20 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_263003_1_414_+ FIG00000097 9 2 10 Phosphatidate cytidylyltransferase (EC 2.7.7.41) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_263004_1_414_+ FIG00000877 95 14 95 Formate--tetrahydrofolate ligase (EC 6.3.4.3) One-carbon metabolism by tetrahydropterines 5 T2D_unique_263012_7_414_- FIG00000296 86 14 87 Glycine cleavage system H protein Glycine and Serine Utilization 1.12 T2D_unique_263021_1_352_- FIG00000578 12 3 13 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_263024_1_414_- FIG00000314 19 6 20 Holliday junction DNA helicase RuvA DNA-replication 4 T2D_unique_263035_1_414_+ FIG00041038 111 16 111 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_263039_1_201_+ FIG00001834 9 3 11 N-acetylmannosaminyltransferase (EC 2.4.1.187) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_263054_1_414_+ FIG00046929 27 9 29 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_263060_1_414_- FIG00000985 58 11 59 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_263065_1_341_- FIG00001555 95 13 96 Cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Putative oxidase COG2907 9 T2D_unique_263082_1_337_+ FIG00000532 4 2 5 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_263093_1_414_- FIG00022976 29 7 31 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_263104_1_241_+ FIG00000323 50 9 51 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_263110_1_272_+ FIG00000289 4 2 6 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_263114_1_414_+ FIG00088533 79 13 80 Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) Cobalamin synthesis 2 T2D_unique_263125_1_414_+ FIG00745599 21 5 22 Alpha-glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_263147_1_292_- FIG01292786 10 2 11 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_263163_1_414_+ FIG00138258 47 9 49 Dihydroxy-acid dehydratase (EC 4.2.1.9) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_263171_1_264_- FIG00003460 74 10 74 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_263181_1_234_- FIG00001882 24 5 24 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_263206_1_170_- FIG00002449 11 3 12 Manganese-dependent protein-tyrosine phosphatase (EC 3.1.3.48) Exopolysaccharide Biosynthesis 1.0 T2D_unique_263215_1_184_- FIG00002177 42 7 42 N-acetylglucosamine-6P-responsive transcriptional repressor NagC, ROK family Chitin and N-acetylglucosamine utilization 2 T2D_unique_263233_1_413_+ FIG00022300 5 3 6 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_263240_192_413_+ FIG00000185 27 5 28 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_263277_1_413_+ FIG00129130 42 11 43 NADP-specific glutamate dehydrogenase (EC 1.4.1.4) Glutamate dehydrogenases 1 T2D_unique_263287_1_413_+ FIG00000146 48 12 49 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_263294_1_413_- FIG00132717 7 3 9 ATP-dependent protease La (EC 3.4.21.53) Type II Proteasome bacterial 1 T2D_unique_263295_1_413_+ FIG00000303 58 12 60 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_unique_263296_1_413_+ FIG00001548 14 6 15 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_263300_1_413_- FIG00000235 40 9 42 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_263310_11_413_- FIG00011468 7 2 9 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_263359_1_413_- FIG00000387 10 3 11 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_263382_61_413_- FIG00002416 43 8 45 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_263403_1_413_- FIG00022631 14 6 19 Acetyl-coenzyme A synthetase (EC 6.2.1.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_263408_1_211_- FIG00000163 6 2 9 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_263410_1_413_+ FIG01304601 94 15 99 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_263438_1_413_+ FIG00050603 19 5 20 Branched-chain amino acid aminotransferase (EC 2.6.1.42) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_263473_1_413_- FIG00030688 12 5 14 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_263497_1_413_+ FIG00000185 8 3 11 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_263517_216_413_+ FIG00002328 5 3 6 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_263532_1_413_+ FIG00000308 114 16 114 3'-to-5' exoribonuclease RNase R RNA processing and degradation, bacterial 1 T2D_unique_263563_82_413_+ FIG00000317 21 4 22 DNA repair protein RecN DNA repair, bacterial 3 T2D_unique_263579_1_413_- FIG00136692 35 9 37 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_263591_1_413_+ FIG00000962 112 16 112 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_263600_1_413_- FIG00000494 8 5 10 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_263601_1_413_- FIG00000114 27 7 29 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_263605_1_413_+ FIG00000055 73 13 75 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_263614_1_413_+ FIG00000395 19 4 21 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_263617_1_413_- FIG00006151 93 14 94 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_263643_1_413_- FIG00001548 22 7 23 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_263645_1_413_- FIG01260980 98 14 98 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_263655_1_413_- FIG00129616 81 13 81 GTP-binding protein EngA Universal GTPases 2 T2D_unique_263666_49_413_+ FIG00002020 11 4 12 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_263668_1_305_- FIG00000203 78 12 78 SSU ribosomal protein S12p (S23e) Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_263708_1_413_+ FIG00002300 104 16 104 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_263741_1_413_+ FIG00005924 24 5 27 Excinuclease ABC subunit A paralog in greater Bacteroides group DNA repair, UvrABC system 1 T2D_unique_263766_1_413_- FIG00001712 5 3 7 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_263804_1_372_+ FIG01257503 27 7 28 Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27) Inositol catabolism 5.x T2D_unique_263844_1_413_- FIG00000011 108 15 108 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_263850_1_413_- FIG00014849 19 4 29 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_263861_1_219_+ FIG00002541 26 5 27 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_263884_1_413_+ FIG00001088 29 7 31 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_263903_1_413_+ FIG00005559 34 10 40 L-proline glycine betaine ABC transport system permease protein ProW (TC 3.A.1.12.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_263927_43_413_+ FIG00719736 7 3 8 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_263944_99_413_+ FIG00134342 47 8 48 Ribose 5-phosphate isomerase B (EC 5.3.1.6) Dihydroxyacetone kinases 3 T2D_unique_263950_1_413_- FIG00047414 64 11 65 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_263969_1_267_- FIG00018561 8 3 9 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_263974_176_413_- FIG00001298 4 2 5 COG1939: Ribonuclease III family protein Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_263998_1_413_+ FIG00000441 112 16 112 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_264012_1_413_+ FIG00000011 4 3 5 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_264021_1_142_+ FIG01260980 22 4 22 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_264034_1_413_+ FIG00000476 13 6 15 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_264044_1_390_+ FIG00134889 18 5 19 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_264046_1_413_+ FIG00229199 74 13 75 Cysteine desulfurase (EC 2.8.1.7), SufS subfamily Alanine biosynthesis A.123 T2D_unique_264088_1_413_+ FIG00134889 23 7 24 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_264102_158_413_- FIG00106663 66 10 66 DNA polymerase III delta subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_264130_146_413_- FIG00000011 6 3 7 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_264136_1_413_+ FIG00000477 5 2 7 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_264138_1_413_+ FIG00132839 108 16 108 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_264145_1_413_- FIG00000594 29 8 30 Chaperone protein HtpG Protein chaperones 2.0 T2D_unique_264159_1_413_- FIG00000146 51 10 53 Excinuclease ABC subunit B DNA repair, UvrABC system 1 T2D_unique_264160_84_413_+ FIG00041382 81 11 81 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_264161_1_413_+ FIG00002320 11 6 14 Dihydropyrimidinase (EC 3.5.2.2) Hydantoin metabolism 4 T2D_unique_264176_1_134_- FIG00002716 28 5 28 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_264176_139_413_- FIG01318398 62 10 62 Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acids Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_264226_1_413_- FIG00001406 27 5 29 Aspartate--ammonia ligase (EC 6.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_264233_1_413_+ FIG00001670 3 2 5 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_264249_1_413_+ FIG00000131 33 9 34 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_264251_1_413_- FIG00000659 28 9 29 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_264265_1_413_+ FIG00138741 72 13 72 Aldehyde dehydrogenase B (EC 1.2.1.22) Methylglyoxal Metabolism 3.x T2D_unique_264329_1_412_+ FIG00002034 5 2 7 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_264336_1_412_+ FIG00000402 58 11 59 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_264363_1_412_- FIG00453259 31 8 33 Sorbitol dehydrogenase (EC 1.1.1.14) Dihydroxyacetone kinases 3 T2D_unique_264368_1_412_- FIG00846773 101 15 101 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_264375_1_412_+ FIG00001166 3 2 4 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_264380_1_412_- FIG00003086 7 4 8 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_264389_1_412_- FIG00002541 29 7 31 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_264392_1_412_- FIG00000636 60 11 61 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_264395_1_220_+ FIG00035627 34 6 34 Glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_264423_1_233_- FIG00060517 8 2 9 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_264437_1_412_+ FIG00011537 36 11 39 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_264471_1_412_+ FIG00018561 52 11 53 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_264472_1_412_- FIG00561498 4 2 5 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_264488_242_412_+ FIG00000095 41 6 41 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_264491_1_227_+ FIG00013339 13 5 14 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_264539_1_412_+ FIG00002470 24 7 27 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_264554_1_395_+ FIG00080955 37 9 38 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_264584_1_333_+ FIG00017186 13 4 14 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK Dihydroxyacetone kinases 3 T2D_unique_264601_1_258_+ FIG00437351 3 2 4 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_unique_264610_1_412_+ FIG00598409 16 8 18 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_264627_1_412_+ FIG00001020 21 5 23 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_264670_1_412_- FIG00042616 9 4 10 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_264694_42_412_+ FIG00133002 22 6 23 Pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_264736_1_238_+ FIG00037431 12 3 13 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_264742_1_412_+ FIG00136692 27 7 29 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_264786_1_412_+ FIG00079822 42 8 43 Aspartate ammonia-lyase (EC 4.3.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_264791_1_412_+ FIG00002968 32 6 33 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_unique_264822_1_412_+ FIG00067681 9 4 10 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_264828_1_148_- FIG00067681 7 2 8 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_264873_1_412_- FIG00000156 60 11 61 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_264901_1_329_- FIG01266244 29 7 31 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_264909_203_412_- FIG00598409 4 2 5 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_264937_1_412_+ FIG00001548 8 3 10 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_264955_1_412_- FIG00561498 11 7 14 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_264970_48_412_+ FIG00000280 29 7 31 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_265007_1_294_- FIG00000494 39 6 41 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_265037_1_412_+ FIG00001054 90 14 90 Dihydroorotate dehydrogenase, catalytic subunit (EC 1.3.3.1) De Novo Pyrimidine Synthesis 1 T2D_unique_265043_34_412_+ FIG00047414 7 4 9 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_265053_22_412_+ FIG00000194 46 10 47 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_265057_153_412_- FIG00013638 3 2 4 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_265059_92_412_+ FIG00000423 9 2 10 Dethiobiotin synthetase (EC 6.3.3.3) Biotin biosynthesis 1X T2D_unique_265063_161_412_- FIG00002328 7 4 8 Acyl carrier protein Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_265064_1_234_- FIG01367215 5 2 6 predicted xylose isomerase Xylose utilization 1 T2D_unique_265073_1_412_+ FIG00146664 54 11 56 Predicted functional analog of homoserine kinase (EC 2.7.1.-) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_265079_1_412_+ FIG00000224 95 14 97 3-dehydroquinate synthase (EC 4.2.3.4) Chorismate Synthesis 1 T2D_unique_265080_1_266_- FIG00000865 69 10 69 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_265083_1_309_- FIG01260980 15 4 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_265093_1_288_+ FIG00001170 56 9 57 3-dehydroquinate dehydratase I (EC 4.2.1.10) Quinate degradation 3 T2D_unique_265094_1_325_- FIG00002974 6 4 8 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_265096_1_412_+ FIG00000191 33 9 36 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_265105_1_412_+ FIG00000328 11 3 12 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_265114_197_412_- FIG00038920 8 2 10 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_265120_116_412_+ FIG00000188 21 7 22 Peptide chain release factor 1 Translation termination factors bacterial 1.13 T2D_unique_265129_236_412_- FIG00002130 10 2 11 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_265141_1_412_- FIG00075970 17 5 19 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) Chorismate Synthesis 1 T2D_unique_265162_1_412_- FIG00000001 6 5 7 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_265167_1_313_+ FIG00000446 18 5 19 Phosphate:acyl-ACP acyltransferase PlsX Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_265169_1_412_- FIG00000085 42 9 43 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_265176_1_374_+ FIG00007508 11 4 15 Nitrite reductase probable [NAD(P)H] subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_unique_265177_186_412_- FIG00040528 7 4 8 Shikimate/quinate 5-dehydrogenase I beta (EC 1.1.1.282) Quinate degradation 3 T2D_unique_265181_1_412_- FIG00001548 30 8 31 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_265185_1_412_+ FIG01260980 17 4 18 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_265209_1_238_+ FIG01007502 58 9 58 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_265223_20_412_+ FIG00005022 75 14 77 ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_265224_1_162_+ FIG00001188 37 6 37 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_265233_116_412_- FIG00016836 8 3 10 Transcription termination protein NusB Transcription factors bacterial 1 T2D_unique_265255_1_411_- FIG00000140 106 16 106 DNA-directed RNA polymerase alpha subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_265286_1_273_+ FIG00139238 9 5 11 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_265292_106_411_- FIG00001561 16 5 18 Probable GTPase related to EngC Universal GTPases 2 T2D_unique_265295_1_411_- FIG00002488 84 15 84 Dihydroxyacetone kinase, ATP-dependent (EC 2.7.1.29) Dihydroxyacetone kinases 3 T2D_unique_265300_162_411_- FIG00001208 16 4 17 [NiFe] hydrogenase metallocenter assembly protein HypD NiFe hydrogenase maturation 1 T2D_unique_265315_1_339_- FIG00000131 24 4 25 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_265345_1_411_+ FIG00000242 15 4 16 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_265350_37_411_- FIG00000329 63 11 64 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_265369_1_411_+ FIG00061313 6 5 7 Replicative DNA helicase (EC 3.6.1.-) DNA-replication 4 T2D_unique_265370_1_411_+ FIG01260980 117 16 117 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_265379_1_310_+ FIG00000207 86 12 86 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_265383_57_411_- FIG00000517 11 4 12 Iron-sulfur cluster-binding protein Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_265392_1_411_- FIG00025216 16 4 18 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_265464_1_411_+ FIG00002049 82 14 82 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_265470_1_411_+ FIG00017306 10 4 11 Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61) Bacterial Chemotaxis 9 T2D_unique_265505_1_411_- FIG00006032 4 2 5 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_265514_1_127_+ FIG00003090 5 2 6 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases CBSS-258594.1.peg.3339 1 T2D_unique_265517_50_411_- FIG00846773 44 8 44 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_265518_1_337_+ FIG00000747 7 2 8 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_265529_1_356_+ FIG00000076 8 2 9 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_265554_1_411_+ FIG00048839 81 12 83 Alpha-N-acetylglucosaminidase (EC 3.2.1.50) Chitin and N-acetylglucosamine utilization 2 T2D_unique_265593_1_382_- FIG01956071 14 3 15 Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) NAD and NADP cofactor biosynthesis global E T2D_unique_265612_217_411_- FIG00000413 12 3 14 Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19) Mycobacterium virulence operon possibly involved in quinolinate biosynthesis 1 T2D_unique_265620_1_408_+ FIG00000101 40 9 43 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_265626_1_411_- FIG00000449 20 6 36 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1) Isoprenoid Biosynthesis 2.x T2D_unique_265655_253_411_+ FIG01290464 9 2 10 Flagellar motor switch protein FliM Bacterial Chemotaxis 9 T2D_unique_265660_1_411_+ FIG00001269 84 14 86 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_265679_1_218_+ FIG00000013 5 2 7 Hydroxyacylglutathione hydrolase (EC 3.1.2.6) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_265683_161_411_+ FIG00000388 65 10 65 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_265695_1_411_- FIG01260980 15 6 16 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_265700_1_389_+ FIG00035893 71 12 73 Nickel ABC transporter, periplasmic nickel-binding protein NikA (TC 3.A.1.5.3) Transport of Nickel and Cobalt 7 T2D_unique_265707_1_411_+ FIG00003472 40 8 43 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_265712_69_411_- FIG00001902 29 6 31 V-type ATP synthase subunit A (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_265722_114_411_+ FIG00023943 19 5 20 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_265740_1_411_- FIG00000350 88 13 88 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_265752_152_411_- FIG00000397 6 2 8 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_265755_1_411_- FIG00121768 15 4 16 Malate permease Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_265793_1_411_- FIG00024401 22 5 27 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_265812_1_240_+ FIG00000404 20 4 21 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_265820_1_411_+ FIG00049915 67 13 68 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_265823_1_411_+ FIG00000111 76 13 77 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_265833_1_388_+ FIG00561498 16 6 18 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_265839_1_411_- FIG00132976 96 15 96 Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33) Acetoin, butanediol metabolism 5 T2D_unique_265852_1_411_+ FIG00004170 32 10 35 HPr kinase/phosphorylase (EC 2.7.1.-) (EC 2.7.4.-) HPr catabolite repression system 1 T2D_unique_265889_1_411_- FIG00000825 63 12 64 Glutaminyl-tRNA synthetase (EC 6.1.1.18) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_265890_1_411_- FIG00000290 16 8 42 Endonuclease III (EC 4.2.99.18) DNA Repair Base Excision 4 T2D_unique_265903_110_411_- FIG00031250 76 12 76 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_265909_1_411_- FIG00003506 4 4 6 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_265910_95_411_+ FIG00066643 9 4 11 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_265926_1_368_+ FIG01260980 104 15 104 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_265930_1_411_+ FIG00000025 108 16 108 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_265936_1_411_- FIG00020040 80 14 86 Predicted nucleoside ABC transporter, permease 1 component Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_265956_1_128_- FIG00003751 13 3 13 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_265957_102_411_+ FIG00073301 83 12 83 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_266052_173_411_+ FIG00001094 16 4 17 Phenylacetate-coenzyme A ligase (EC 6.2.1.30) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_266060_1_174_- FIG00000368 7 2 8 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_266064_1_277_+ FIG00459778 17 4 19 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_266069_1_411_+ FIG00018392 41 10 43 Exopolysaccharide biosynthesis transcriptional activator EpsA Exopolysaccharide Biosynthesis 1.0 T2D_unique_266076_1_411_- FIG00041038 62 12 64 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_266077_1_411_+ FIG00048839 37 8 39 Alpha-N-acetylglucosaminidase (EC 3.2.1.50) Chitin and N-acetylglucosamine utilization 2 T2D_unique_266093_97_411_- FIG00000323 55 11 55 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) DNA repair, bacterial 3 T2D_unique_266101_1_385_+ FIG00000717 107 15 107 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) Glycogen metabolism 3 T2D_unique_266113_1_411_+ FIG00000112 63 14 64 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_266124_1_258_- FIG00010844 32 6 33 Flavodoxin Flavodoxin 1 T2D_unique_266126_1_411_- FIG00001385 18 6 21 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_266145_1_411_- FIG01304601 6 3 8 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_266147_1_411_+ FIG00000338 88 16 88 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_266154_202_411_- FIG00001687 18 4 19 Sarcosine oxidase alpha subunit (EC 1.5.3.1) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_266159_1_411_- FIG00010876 9 3 10 Two-component sensor kinase YesM (EC 2.7.3.-) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_266171_1_279_+ FIG00000205 40 8 41 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_266188_1_410_- FIG00001469 28 8 30 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_266195_1_410_- FIG00001469 11 3 12 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_266199_1_410_- FIG00080955 95 14 96 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_266202_1_250_+ FIG00229695 52 8 52 Histidine triad (HIT) nucleotide-binding protein, similarity with At5g48545 and yeast YDL125C (HNT1) CBSS-176279.3.peg.1262 1.x T2D_unique_266227_1_362_- FIG00000128 96 14 96 Serine acetyltransferase (EC 2.3.1.30) Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_266232_1_410_- FIG00133628 18 4 20 Nitric oxide reductase activation protein NorD Flavohaemoglobin 1 T2D_unique_266240_1_410_+ FIG00000636 78 13 79 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_266276_1_410_- FIG00022488 82 14 82 Gluconate permease D-gluconate and ketogluconates metabolism 1.3 T2D_unique_266294_1_410_- FIG00018369 117 16 117 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_266311_36_410_- FIG00002387 87 13 88 Phosphatidylglycerophosphatase B (EC 3.1.3.27) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_266320_63_410_- FIG00079521 69 11 70 TRAP dicarboxylate transporter, DctM subunit, unknown substrate 8 CBSS-49338.1.peg.459 1 T2D_unique_266333_1_410_- FIG00000365 59 10 61 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_266353_1_227_+ FIG00004078 33 6 34 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_266358_1_410_+ FIG00004078 13 4 17 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_266363_1_410_+ FIG00000206 20 7 21 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_266376_1_410_- FIG00000207 88 15 88 Cobalt-zinc-cadmium resistance protein Cobalt-zinc-cadmium resistance 1.26 T2D_unique_266393_1_298_+ FIG00001088 23 6 24 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_266394_1_217_- FIG00001670 21 5 23 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_266396_1_410_- FIG00006463 18 5 19 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_266397_1_251_+ FIG00000304 53 9 53 GTP-binding protein HflX Hfl operon 1.111 T2D_unique_266406_1_410_+ FIG00000382 88 14 89 Ribonucleotide reductase transcriptional regulator NrdR Ribonucleotide reduction 1 T2D_unique_266407_261_410_- FIG00000479 37 6 37 Zinc uptake regulation protein ZUR Zinc regulated enzymes 1 T2D_unique_266408_1_410_+ FIG00003580 19 3 22 Lipopolysaccharide cholinephosphotransferase LicD1 (EC 2.7.8.-) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_266471_1_410_+ FIG00009014 66 13 67 Anaerobic sulfite reductase subunit C (EC 1.8.1.-) Anaerobic respiratory reductases 3 T2D_unique_266492_1_410_- FIG00007328 14 5 16 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_266501_1_410_- FIG00093180 3 2 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_266529_1_410_+ FIG00041038 67 13 68 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_266538_1_257_- FIG00002344 13 4 15 FIG002344: Hydrolase (HAD superfamily) CBSS-257314.1.peg.676 4.x T2D_unique_266572_1_273_- FIG00013638 45 9 45 ATPase component of general energizing module of ECF transporters ECF class transporters 345678 T2D_unique_266588_1_410_- FIG00023943 103 15 103 DNA polymerase IV (EC 2.7.7.7) DNA repair, bacterial 3 T2D_unique_266594_1_410_- FIG00000147 30 9 32 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_266597_1_410_+ FIG00044622 106 15 107 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_266602_1_410_- FIG00001798 3 2 4 Co-activator of prophage gene expression IbrA IbrA and IbrB: co-activators of prophage gene expression 1 T2D_unique_266616_1_410_+ FIG00000114 104 15 104 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_266625_27_347_- FIG00000312 3 2 5 16S rRNA processing protein RimM KH domain RNA binding protein YlqC 1.11 T2D_unique_266629_1_410_+ FIG00000377 16 5 17 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_266630_1_168_+ FIG00000223 41 6 41 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_266633_1_356_+ FIG00000226 27 7 28 GTP cyclohydrolase I (EC 3.5.4.16) type 1 Zinc regulated enzymes 1 T2D_unique_266637_1_410_+ FIG00080231 27 7 28 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_266684_1_276_+ FIG00003555 30 5 31 Phosphoglycolate phosphatase (EC 3.1.3.18) 2-phosphoglycolate salvage 1 T2D_unique_266696_1_410_+ FIG00001029 10 4 13 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_266710_39_410_+ FIG00009450 52 9 53 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_266712_1_410_+ FIG00120441 14 5 17 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_266719_162_410_- FIG00561498 27 5 28 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_266723_1_410_+ FIG00001088 29 6 30 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_266727_44_410_- FIG00001346 54 10 55 Cystathionine gamma-lyase (EC 4.4.1.1) Methionine Degradation 3 T2D_unique_266736_1_410_- FIG00020897 9 3 10 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_266749_1_410_- FIG00846773 117 16 117 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_266767_1_410_+ FIG00000390 97 15 97 Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_266780_1_410_- FIG00001088 6 2 8 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_266783_1_164_- FIG00133292 8 3 9 Electron transport complex protein RnfB Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_266784_212_410_- FIG00074196 9 4 10 D-glycerate 2-kinase (EC 2.7.1.-) D-galactarate, D-glucarate and D-glycerate catabolism 1 T2D_unique_266795_1_410_+ FIG00008264 108 16 108 Osmotically activated L-carnitine/choline ABC transporter, substrate-binding protein OpuCC Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_266832_1_276_- FIG00000032 61 9 62 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_266842_1_410_+ FIG00000391 79 14 81 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_266846_1_410_+ FIG01260980 28 7 29 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_266849_1_410_- FIG01260980 20 3 21 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_266914_1_410_+ FIG00000899 25 5 26 Endonuclease IV (EC 3.1.21.2) DNA repair, bacterial 3 T2D_unique_266915_1_410_+ FIG00041038 14 5 16 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_266918_1_337_+ FIG00001758 88 13 88 Late competence protein ComGB, access of DNA to ComEA Gram Positive Competence 3100 T2D_unique_266931_1_180_+ FIG00000276 41 6 41 LSU ribosomal protein L21p CBSS-176279.3.peg.868 1.x T2D_unique_266942_1_410_+ FIG00000793 5 3 6 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_266962_1_299_- FIG00000242 34 8 34 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_266972_1_410_+ FIG00017454 10 3 12 Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8) Aromatic amino acid interconversions with aryl acids 1.4 T2D_unique_266991_1_285_+ FIG00002839 21 6 22 MutS-related protein, family 1 DNA repair, bacterial MutL-MutS system 1 T2D_unique_267004_1_282_- FIG00561498 72 11 72 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_267033_1_410_+ FIG00000111 17 4 19 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_267041_1_369_+ FIG00000348 49 9 50 Porphobilinogen synthase (EC 4.2.1.24) Zinc regulated enzymes 1 T2D_unique_267043_1_410_+ FIG00598409 20 5 22 Mannose-6-phosphate isomerase (EC 5.3.1.8) Mannose Metabolism 2.0 T2D_unique_267045_199_410_- FIG00000055 50 8 50 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_267084_1_410_- FIG00018369 5 2 6 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_267105_1_410_+ FIG00001209 12 4 13 [NiFe] hydrogenase metallocenter assembly protein HypF NiFe hydrogenase maturation 1 T2D_unique_267138_1_410_+ FIG00000086 87 14 89 Cysteinyl-tRNA synthetase (EC 6.1.1.16) Zinc regulated enzymes 1 T2D_unique_267141_9_410_- FIG00003129 86 13 87 Galactose operon repressor, GalR-LacI family of transcriptional regulators Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_267142_1_410_+ FIG00000441 95 15 96 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_267154_1_410_+ FIG00000578 9 2 10 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_267160_158_409_+ FIG00059426 8 5 9 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_267183_1_409_- FIG00018699 5 3 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_267184_98_409_- FIG00001269 13 3 14 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_267210_1_409_- FIG00000402 48 10 50 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_267212_1_409_+ FIG01260980 42 9 43 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_267234_220_409_- FIG01266244 11 2 13 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_267252_229_409_- FIG00000298 14 3 15 GTP-binding protein EngB Universal GTPases 2 T2D_unique_267253_1_177_- FIG00013156 9 3 10 Putative ABC transporter ATP-binding protein, spy1790 homolog Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_267260_1_409_+ FIG00002110 123 16 123 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I alpha (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_267285_1_409_+ FIG00003788 17 5 18 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_267303_1_409_- FIG00000168 51 8 52 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_267326_1_409_- FIG00000476 15 7 16 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_267347_1_409_- FIG00008490 52 10 53 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_267398_99_409_+ FIG00001642 3 3 5 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_267404_1_290_- FIG00005860 7 4 9 SusD, outer membrane protein Cellulosome 1.x T2D_unique_267422_1_130_+ FIG00000402 22 4 22 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_267423_1_409_+ FIG00036224 85 15 85 Sialidase (EC 3.2.1.18) Sialic Acid Metabolism 1.x T2D_unique_267430_1_251_+ FIG00000770 9 5 12 Arsenate reductase (EC 1.20.4.1) Arsenic resistance 1 T2D_unique_267446_1_180_- FIG00001133 46 7 46 COG2740: Predicted nucleic-acid-binding protein implicated in transcription termination Transcription factors bacterial 1 T2D_unique_267446_230_409_- FIG00000168 38 6 38 Transcription termination protein NusA Transcription factors bacterial 1 T2D_unique_267449_36_409_- FIG00003751 11 4 13 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_267458_1_409_+ FIG00006151 9 7 23 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_267459_1_409_+ FIG00045575 3 3 5 O-antigen export system, permease protein Rhamnose containing glycans 4.1 T2D_unique_267486_1_409_- FIG00001029 21 7 24 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_267497_41_409_- FIG00000234 86 14 86 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_267509_1_297_- FIG00846773 25 6 26 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_267521_221_409_- FIG00001497 44 7 44 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Cell division-ribosomal stress proteins cluster 1 T2D_unique_267529_64_409_+ FIG00031250 22 5 24 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_267554_1_409_- FIG00006764 9 3 11 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_267565_1_409_- FIG00000163 82 13 83 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_267569_1_409_+ FIG00002470 35 7 36 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_267578_1_409_+ FIG00059211 9 3 10 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_267580_61_399_+ FIG00014849 84 12 85 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_267608_1_409_+ FIG00000491 105 14 106 Queuosine Biosynthesis QueC ATPase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_267618_1_409_- FIG00000865 4 2 6 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) Histidine Biosynthesis 1 T2D_unique_267635_1_409_+ FIG00039969 11 3 12 CRISPR-associated protein, Csm5 family CRISPR-associated cluster 1 T2D_unique_267645_1_171_- FIG00006150 23 4 24 Nondeblocking aminopeptidase YpdE (X-X-[^PR]- specific) Protein degradation 1 T2D_unique_267654_1_409_+ FIG00000117 4 3 5 Adenylosuccinate lyase (EC 4.3.2.2) Purine conversions 4.1118100 T2D_unique_267675_1_409_- FIG00000709 31 6 32 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) Periplasmic disulfide interchange 1 T2D_unique_267690_1_301_- FIG00000402 20 5 21 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_267694_1_409_+ FIG00018369 39 10 40 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_267697_1_409_- FIG00063189 34 10 36 Translation elongation factor G Translation elongation factors bacterial 1.1 T2D_unique_267721_1_409_- FIG00000139 53 12 54 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_267725_1_164_- FIG00008348 35 5 35 Predicted transcriptional regulator of N-Acetylglucosamine utilization, GntR family Chitin and N-acetylglucosamine utilization 2 T2D_unique_267739_1_409_+ FIG00000241 69 12 70 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_267747_1_409_- FIG00133325 37 7 40 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_267757_1_409_- FIG00012945 7 4 8 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_267759_1_409_+ FIG00001548 12 5 14 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_267784_1_409_- FIG00046358 24 5 27 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_267812_1_409_- FIG00000383 55 10 56 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_267823_1_193_- FIG01260980 6 3 7 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_267843_99_409_+ FIG01290653 30 8 31 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_267851_230_409_- FIG00000102 22 5 24 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_267858_1_348_+ FIG00015476 46 9 47 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_unique_267862_1_409_- FIG00005728 3 2 4 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_267863_1_409_- FIG00004078 6 3 7 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_267867_1_409_+ FIG00008273 7 4 10 N-acetylneuraminate synthase (EC 2.5.1.56) Sialic Acid Metabolism 1.x T2D_unique_267891_1_409_+ FIG00080955 99 16 100 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_267904_1_409_+ FIG00004655 43 8 45 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_267917_254_409_- FIG00005283 11 4 12 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_267929_1_208_- FIG00001547 24 5 25 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_267929_213_409_- FIG00052730 38 6 39 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_267942_1_256_+ FIG00048014 3 3 5 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_267951_1_409_+ FIG00001712 27 6 28 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_267958_1_409_- FIG00000245 67 13 68 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_267960_1_361_+ FIG00122145 100 14 100 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_267963_1_409_+ FIG00000001 22 4 28 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_267965_1_396_+ FIG00002974 9 6 12 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_267966_261_409_+ FIG00000395 20 3 21 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_267977_1_336_+ FIG00000873 17 4 22 Nitrite reductase [NAD(P)H] large subunit (EC 1.7.1.4) Nitrate and nitrite ammonification 1 T2D_unique_268025_241_409_- FIG01292786 8 2 9 Aldehyde dehydrogenase (EC 1.2.1.3) Methylglyoxal Metabolism 3.x T2D_unique_268029_1_269_+ FIG00007797 46 9 46 mannose-specific adhesin FimH Type 1 pili (mannose-sensitive fimbriae) 1.x T2D_unique_268032_1_409_- FIG01303154 33 7 34 Ubiquinone/menaquinone biosynthesis methyltransferase UbiE (EC 2.1.1.-) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_268069_170_409_- FIG00001635 34 6 34 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_268079_1_409_+ FIG00000047 23 7 25 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_268084_1_409_+ FIG00083946 4 5 30 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_268089_1_269_+ FIG00000131 7 3 8 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_268090_1_409_+ FIG00006734 81 13 83 4-amino-6-deoxy-N-Acetyl-D-hexosaminyl-(Lipid carrier) acetyltrasferase N-linked Glycosylation in Bacteria 2.0 T2D_unique_268093_1_408_- FIG00001269 42 7 43 Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Methionine Degradation 3 T2D_unique_268100_1_408_+ FIG00000404 8 5 11 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_268130_1_408_+ FIG00003472 41 11 43 UDP-galactopyranose mutase (EC 5.4.99.9) LOS core oligosaccharide biosynthesis 1.x T2D_unique_268153_1_233_- FIG01960218 35 8 36 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_268163_1_408_- FIG00000075 107 16 107 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_268175_26_408_+ FIG00000043 27 6 28 Pyruvate kinase (EC 2.7.1.40) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_268184_178_408_- FIG00000504 27 5 28 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_268197_1_408_+ FIG00004589 56 11 56 Putative deoxyribose-specific ABC transporter, ATP-binding protein Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_268204_47_349_+ FIG01260980 13 5 14 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_268205_72_408_+ FIG00001548 5 2 7 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_268238_1_408_- FIG00007658 7 5 9 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_268273_1_372_+ FIG00012067 14 3 16 Substrate-specific component BioY of biotin ECF transporter ECF class transporters 345678 T2D_unique_268285_1_408_+ FIG00002130 85 12 90 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_268293_14_408_+ FIG00018369 28 7 30 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_268297_1_408_- FIG00000590 98 15 99 NAD synthetase (EC 6.3.1.5) NAD and NADP cofactor biosynthesis global E T2D_unique_268318_1_408_- FIG00137607 32 7 34 Proline racemase (EC 5.1.1.4) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_268319_1_307_- FIG00018561 4 2 6 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_268321_1_171_+ FIG00000584 29 6 29 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_268356_1_408_- FIG00000402 17 5 19 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_268358_1_408_- FIG01304601 107 16 107 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_268359_1_408_+ FIG00001469 5 2 6 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_268370_1_232_- FIG00006032 10 3 11 Cobalamin synthase Cobalamin synthesis 2 T2D_unique_268380_1_408_- FIG00018457 23 7 25 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_268396_1_408_+ FIG00001882 98 15 100 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_268400_1_334_- FIG00168885 53 10 54 Cellobiose phosphorylase (EC 2.4.1.-) Beta-Glucoside Metabolism 2.bc T2D_unique_268412_1_348_+ FIG00002974 6 3 7 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_268433_1_408_+ FIG00000139 16 4 17 Alanyl-tRNA synthetase (EC 6.1.1.7) tRNA aminoacylation, Ala 1.01 T2D_unique_268461_1_408_- FIG00000185 36 8 38 Excinuclease ABC subunit C DNA repair, UvrABC system 1 T2D_unique_268474_215_408_+ FIG00017186 39 6 39 Phosphoenolpyruvate-dihydroxyacetone phosphotransferase (EC 2.7.1.121), dihydroxyacetone binding subunit DhaK Dihydroxyacetone kinases 3 T2D_unique_268477_1_408_+ FIG00000107 13 5 16 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_268499_1_408_- FIG00000107 46 9 48 Adenylosuccinate synthetase (EC 6.3.4.4) Histidine Biosynthesis 1 T2D_unique_268502_1_408_+ FIG00029916 89 15 90 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_268504_1_218_+ FIG00000915 4 2 5 Hypothetical protein YaeJ with similarity to translation release factor Translation termination factors bacterial 1.13 T2D_unique_268510_1_317_+ FIG00001732 3 2 4 Aminopeptidase C (EC 3.4.22.40) Protein degradation 1 T2D_unique_268511_1_408_- FIG00002252 28 7 29 Galactose/methyl galactoside ABC transport system, D-galactose-binding periplasmic protein MglB (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_268516_1_408_- FIG00002541 8 3 9 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_268519_1_408_+ FIG00000287 43 8 45 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_268523_1_408_+ FIG00049915 94 15 94 GTP-binding and nucleic acid-binding protein YchF Universal GTPases 2 T2D_unique_268524_1_408_+ FIG00000387 53 11 55 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_268534_1_408_- FIG00046929 58 8 59 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_268542_1_408_- FIG00000532 32 7 33 UDP-glucose dehydrogenase (EC 1.1.1.22) Streptococcal Hyaluronic Acid Capsule 1 T2D_unique_268557_117_408_- FIG00000134 24 7 25 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_268570_13_408_- FIG00000235 28 7 30 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_268578_1_408_+ FIG00023004 111 16 111 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_268579_1_408_+ FIG00018369 74 12 75 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_268598_1_408_- FIG00041038 112 16 112 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_268608_1_282_- FIG00002857 28 6 29 Thiol peroxidase, Tpx-type (EC 1.11.1.15) Thioredoxin-disulfide reductase 2 T2D_unique_268609_1_408_- FIG00000476 6 4 7 Glycogen phosphorylase (EC 2.4.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_268619_1_408_- FIG00001384 9 4 14 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_268638_1_408_- FIG00029916 9 2 12 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_268661_1_335_- FIG00000032 15 4 18 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_268672_1_408_+ FIG00001548 22 5 23 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_268694_1_408_+ FIG00034293 80 14 81 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_268696_1_408_+ FIG01260980 119 16 119 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_268704_1_408_+ FIG00035175 22 5 23 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_268711_1_378_+ FIG00005243 31 6 32 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_268716_1_408_- FIG00000504 9 3 10 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_268717_1_408_+ FIG00002416 91 14 92 DinG family ATP-dependent helicase CPE1197 DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_268729_1_408_- FIG00018865 26 7 27 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_268738_1_408_+ FIG00005237 3 2 4 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_268742_1_408_+ FIG00000187 45 9 46 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) dTDP-rhamnose synthesis 2.0 T2D_unique_268743_1_408_+ FIG00030191 16 7 19 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_268744_1_408_+ FIG00018699 7 5 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_268755_1_408_+ FIG00000595 27 5 29 DNA recombination protein RmuC DNA repair, bacterial 3 T2D_unique_268757_1_408_+ FIG00000439 22 4 25 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_268766_1_408_- FIG00066643 118 16 118 Neopullulanase (EC 3.2.1.135) Maltose and Maltodextrin Utilization 1.x T2D_unique_268801_1_408_+ FIG00007960 8 2 10 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_268811_12_408_- FIG00000011 10 4 19 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_268840_82_408_+ FIG00000268 13 4 16 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_268842_1_408_- FIG00000288 56 9 57 Transcription elongation factor GreA Transcription factors bacterial 1 T2D_unique_268860_1_408_+ FIG00001549 111 16 112 Hypothetical protein DUF901, similar to C-terminal domain of ribosome protection-type Tc-resistance proteins Conserved gene cluster possibly involved in RNA metabolism 1 T2D_unique_268862_1_408_- FIG00001642 96 14 98 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_268890_1_155_- FIG00002239 34 5 34 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_268902_62_408_+ FIG00002239 32 8 33 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_268922_181_408_- FIG00024401 11 3 12 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10) Peptidoglycan Biosynthesis 1.9 T2D_unique_268924_1_237_- FIG00000445 14 2 15 Phosphoserine aminotransferase (EC 2.6.1.52) Serine Biosynthesis 2.x T2D_unique_268954_1_408_- FIG00044622 6 2 8 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_268957_1_266_- FIG00001822 5 2 6 Pantothenate:Na+ symporter (TC 2.A.21.1.1) Coenzyme A Biosynthesis A.191 T2D_unique_268962_1_408_- FIG00018369 63 12 64 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_268964_1_408_+ FIG00008591 31 6 32 N-Acetyl-D-glucosamine ABC transport system, permease protein 1 Chitin and N-acetylglucosamine utilization 2 T2D_unique_268966_1_408_+ FIG00047056 9 3 10 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) Peptidoglycan Biosynthesis 1.9 T2D_unique_268973_1_408_+ FIG01955818 121 16 121 Pyruvate:ferredoxin oxidoreductase, alpha subunit (EC 1.2.7.1) Pyruvate:ferredoxin oxidoreductase 3 T2D_unique_268976_217_408_+ FIG00000264 6 4 8 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_unique_268978_1_303_+ FIG00077620 69 10 69 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_268981_1_408_- FIG00006764 18 5 22 Rhamnogalacturonides degradation protein RhiN L-rhamnose utilization 1 T2D_unique_268985_1_408_- FIG00003086 29 5 30 Beta-xylosidase (EC 3.2.1.37) Xylose utilization 1 T2D_unique_269009_1_408_- FIG00060517 44 12 46 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_269024_1_408_+ FIG00000420 28 7 29 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_269045_1_408_- FIG00030688 29 7 30 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) dTDP-rhamnose synthesis 2.0 T2D_unique_269053_1_407_+ FIG00034293 45 9 46 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_269069_1_407_+ FIG00003715 86 14 86 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) N-linked Glycosylation in Bacteria 2.0 T2D_unique_269081_109_407_+ FIG00018699 8 3 9 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_269083_1_407_- FIG00000011 72 11 84 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_269145_1_407_+ FIG00135469 113 16 113 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_269146_70_407_- FIG00066425 28 7 29 DNA polymerase III beta subunit (EC 2.7.7.7) Cell Division Subsystem including YidCD 1 T2D_unique_269167_1_407_- FIG00001076 28 7 29 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_269181_113_407_- FIG01303895 59 10 60 GDP-mannose mannosyl hydrolase (EC 3.6.1.-) Mannose Metabolism 2.0 T2D_unique_269188_114_407_+ FIG00000897 4 2 5 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_269189_1_407_- FIG01260980 57 12 59 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_269193_202_407_+ FIG00044622 32 7 33 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_269198_276_407_+ FIG00008490 6 2 7 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_269237_1_407_- FIG00016818 5 2 7 Putative polyribitolphosphotransferase Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_269241_1_318_+ FIG00623809 52 9 52 Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_269246_1_407_+ FIG00001105 8 4 9 tRNA (cytosine34-2'-O-)-methyltransferase (EC 2.1.1.-) Glutaredoxins 1 T2D_unique_269260_1_407_+ FIG00000176 9 5 23 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_269268_1_407_- FIG00023004 27 6 28 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_269271_1_407_- FIG00001088 75 10 76 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_269280_30_407_- FIG00001401 16 7 17 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_269303_1_407_- FIG00004655 105 15 105 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_269314_264_407_+ FIG00001647 3 2 4 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_269316_1_336_+ FIG00001088 54 9 54 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_269384_1_407_+ FIG00046929 74 12 75 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_269388_1_407_+ FIG00000494 11 7 17 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_269391_1_407_+ FIG01260980 29 6 31 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_269398_112_407_+ FIG00001210 24 5 26 [NiFe] hydrogenase nickel incorporation-associated protein HypB NiFe hydrogenase maturation 1 T2D_unique_269401_1_186_- FIG00000439 30 5 31 Topoisomerase IV subunit B (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_269421_1_407_- FIG00002470 9 3 10 Probable poly(beta-D-mannuronate) O-acetylase (EC 2.3.1.-) Alginate metabolism 4.xx T2D_unique_269437_1_407_- FIG00000028 116 16 116 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_269443_1_299_+ FIG00003998 62 10 63 V-type ATP synthase subunit K (EC 3.6.3.14) V-Type ATP synthase 1 T2D_unique_269450_1_407_- FIG00000477 40 8 41 Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) Restriction-Modification System 3.x T2D_unique_269454_1_407_+ FIG00046929 14 5 15 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_269460_1_407_+ FIG00000028 26 7 28 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_269491_99_407_+ FIG01007502 22 7 24 Alcohol dehydrogenase (EC 1.1.1.1) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_269509_1_407_+ FIG00000402 9 4 12 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_269514_33_221_- FIG00002489 27 5 30 Spore germination protein GerKA Spore germination 1 T2D_unique_269516_1_407_+ FIG00000356 40 8 41 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_269521_1_407_- FIG00000356 12 2 13 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_269545_1_302_- FIG00059211 21 4 25 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_269548_1_246_- FIG01955809 15 4 16 Cytoplasmic copper homeostasis protein cutC Copper homeostasis: copper tolerance 3 T2D_unique_269567_1_407_+ FIG00136692 15 5 16 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_269574_1_407_- FIG00048014 11 3 13 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_269583_1_407_+ FIG00003756 114 16 114 Maltose-6'-phosphate glucosidase (EC 3.2.1.122) Maltose and Maltodextrin Utilization 1.x T2D_unique_269605_1_407_- FIG00000132 93 15 95 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_269612_226_407_+ FIG00000200 20 5 21 LSU ribosomal protein L18p (L5e) Ribosome LSU bacterial 9 T2D_unique_269613_139_402_+ FIG01956713 11 3 12 ABC-transporter (ATP-binding protein) -possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide Rhamnose containing glycans 4.1 T2D_unique_269637_1_407_- FIG00038343 8 5 10 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_269653_145_407_+ FIG00002974 22 6 24 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_269672_1_407_- FIG00000356 63 11 64 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_269715_1_407_+ FIG00031825 12 7 28 Hydrogen peroxide-inducible genes activator DNA-binding regulatory proteins, strays 1 T2D_unique_269718_1_407_- FIG00000112 5 3 8 Methionyl-tRNA formyltransferase (EC 2.1.2.9) CBSS-89187.3.peg.2957 1 T2D_unique_269719_1_355_- FIG00016663 13 3 21 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_269724_1_407_+ FIG00000822 18 7 20 LrgA-associated membrane protein LrgB Murein hydrolase regulation and cell death 1.2 T2D_unique_269740_1_407_+ FIG00000114 41 10 42 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_269742_1_387_+ 100 15 100 LSU m3Psi1915 methyltransferase RlmH NAD and NADP cofactor biosynthesis global E T2D_unique_269759_1_407_+ FIG00010600 25 5 26 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_269767_1_407_+ FIG00000606 105 15 105 Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) Ribonucleotide reduction 1 T2D_unique_269786_1_407_+ FIG00001635 78 12 78 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_269795_1_407_+ FIG00000212 22 5 23 Chorismate synthase (EC 4.2.3.5) Chorismate Synthesis 1 T2D_unique_269817_1_407_+ FIG00000380 14 3 16 DNA mismatch repair protein MutL DNA repair, bacterial MutL-MutS system 1 T2D_unique_269831_1_298_- FIG00000578 27 8 28 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_269833_1_407_- FIG01955844 3 2 4 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_269851_267_407_+ FIG00000087 26 4 27 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_269877_1_407_- FIG00043527 8 3 9 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_269878_1_407_- FIG00001469 102 15 102 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_269894_1_407_- FIG00001505 17 5 19 Electron transport complex protein RnfA Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_269899_1_267_+ FIG00140093 10 2 11 Putative arylsulfatase regulatory protein Alkanesulfonate assimilation 9.? T2D_unique_269900_1_407_+ FIG00000377 13 4 15 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_269908_1_407_+ FIG00012267 108 16 108 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_269935_1_407_+ FIG00060517 3 2 4 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_269945_1_407_- FIG00000287 17 5 18 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_269948_1_407_+ FIG00135469 17 6 18 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_269964_1_407_+ FIG00003520 4 3 6 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_269968_1_407_- FIG00000056 9 4 10 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_269974_1_407_- FIG00001537 6 2 10 Cytochrome c552 precursor (EC 1.7.2.2) Nitrate and nitrite ammonification 1 T2D_unique_270000_1_407_- FIG00135554 63 12 64 UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8) Peptidoglycan Biosynthesis 1.9 T2D_unique_270004_1_405_+ FIG00134060 24 6 26 Electron transport complex protein RnfE Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_270005_1_407_+ FIG00000402 22 4 24 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_270053_1_406_+ FIG00007957 9 3 10 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_270060_1_406_- FIG00000343 61 12 62 1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_270070_1_406_+ FIG00036406 78 14 79 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_270086_1_406_+ FIG00002920 86 14 87 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) Chorismate Synthesis 1 T2D_unique_270093_1_406_+ FIG00026918 106 16 106 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_270121_1_406_+ FIG00001667 3 4 6 Macrolide export ATP-binding/permease protein MacB (EC 3.6.3.-) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_270132_1_406_+ FIG00000636 49 12 50 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_270137_1_406_- FIG00067300 23 7 25 Nicotinamidase (EC 3.5.1.19) Redox-dependent regulation of nucleus processes 2 T2D_unique_270139_1_406_- FIG00022300 12 3 14 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_270153_158_406_- FIG00000206 63 9 63 Translation initiation factor 3 Translation initiation factors bacterial 1.111 T2D_unique_270154_1_315_+ FIG00000383 5 2 6 Acetylglutamate kinase (EC 2.7.2.8) Arginine Biosynthesis extended 1.0 T2D_unique_270162_1_406_- FIG00023004 79 13 79 Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1) Purine conversions 4.1118100 T2D_unique_270203_129_406_- FIG00618007 27 4 28 Thiol:disulfide oxidoreductase related to ResA CBSS-196164.1.peg.461 2 T2D_unique_270204_163_406_+ FIG00002620 11 3 12 Tyrosine-protein kinase transmembrane modulator EpsC Exopolysaccharide Biosynthesis 1.0 T2D_unique_270220_1_406_- FIG00006463 96 15 96 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_270227_1_406_+ FIG00022300 53 11 55 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_270282_1_406_+ FIG00000245 110 16 111 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_270287_1_315_- FIG00000687 55 9 56 Adenosine deaminase (EC 3.5.4.4) Purine conversions 4.1118100 T2D_unique_270293_39_406_+ FIG00904859 9 4 12 Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) Glutaredoxins 1 T2D_unique_270294_1_135_+ FIG00000268 24 4 24 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_270324_1_406_- FIG00010675 49 11 50 Formate efflux transporter (TC 2.A.44 family) Formate hydrogenase 3.1?? T2D_unique_270328_1_161_+ FIG00004037 41 6 41 Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_270328_170_406_+ FIG00003894 49 9 49 Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_270341_1_406_- FIG01955844 89 13 89 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_270344_1_406_+ FIG00001469 7 3 9 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_270355_1_406_- FIG00000793 116 16 116 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_270370_1_315_+ FIG00093180 4 2 6 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_270377_1_406_- FIG01304998 93 14 93 RND efflux system, membrane fusion protein CmeA Multidrug Resistance Efflux Pumps 1.12 T2D_unique_270382_138_406_+ FIG00000165 32 7 32 Translation elongation factor LepA Translation elongation factors bacterial 1.1 T2D_unique_270383_1_406_- FIG00051439 84 15 85 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_270425_1_406_- FIG00001583 10 3 13 FIG001583: hypothetical protein, contains S4-like RNA binding domain Cell Division Cluster 1.x T2D_unique_270443_1_265_+ FIG01260980 49 7 50 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_270444_1_406_- FIG00001712 24 8 26 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_270459_1_182_+ FIG00000408 10 2 11 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) Capsular heptose biosynthesis 1 T2D_unique_270462_1_406_+ FIG00004763 30 8 31 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_270502_1_319_- FIG00022300 54 9 55 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_270512_13_406_- FIG00066397 5 4 8 tRNA-dependent lipid II--amino acid ligase tRNA-dependent amino acid transfers 1 T2D_unique_270522_1_233_- FIG00003394 57 8 57 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_270531_1_406_- FIG00136922 55 9 56 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_270540_1_406_+ FIG00002818 3 2 4 Inner membrane protein translocase component YidC, long form Cell Division Subsystem including YidCD 1 T2D_unique_270547_1_406_- FIG00080955 81 13 82 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_270551_1_406_- FIG00003174 7 3 8 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_270583_1_406_+ FIG00019497 104 15 104 Beta-ureidopropionase (EC 3.5.1.6) Hydantoin metabolism 4 T2D_unique_270584_1_406_- FIG00038343 6 3 8 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_270604_1_406_+ FIG00000425 5 4 6 Topoisomerase IV subunit A (EC 5.99.1.-) DNA topoisomerases, Type II, ATP-dependent 1.100 T2D_unique_270614_1_406_+ FIG00000397 77 12 78 Glutamate racemase (EC 5.1.1.3) Peptidoglycan Biosynthesis 1.9 T2D_unique_270640_1_373_- FIG00002799 9 5 10 Phosphoheptose isomerase 1 (EC 5.3.1.-) Capsular heptose biosynthesis 1 T2D_unique_270647_1_222_- FIG00002803 3 3 4 Membrane-associated zinc metalloprotease Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_270651_1_406_- FIG00134889 110 16 110 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_270672_1_380_- FIG00001548 28 7 29 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_270680_1_180_+ FIG00055520 14 3 17 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_270702_1_406_- FIG00019251 4 3 6 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_270716_1_341_+ FIG01256546 6 3 8 Hypothetical sugar kinase in cluster with indigoidine synthase indA , PfkB family of kinases CBSS-176299.3.peg.235 3 T2D_unique_270745_1_406_+ FIG00000434 46 9 47 Homoserine dehydrogenase (EC 1.1.1.3) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_270758_68_406_- FIG00093180 4 3 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_270759_1_406_- FIG00000474 22 8 24 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_270767_1_406_- FIG00621886 4 4 6 Putative arylsulfate sulfotransferase (EC 2.8.2.22) Biogenesis of c-type cytochromes 1.1 T2D_unique_270778_1_406_+ FIG00021289 6 3 8 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_270797_1_406_+ FIG00020897 87 13 89 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_270799_186_406_+ FIG00000176 38 7 39 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_270807_1_406_- FIG00080231 33 7 34 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_270810_1_406_- FIG00005666 29 5 31 FIG005666: putative helicase Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 10.x T2D_unique_270812_1_406_- FIG01304149 99 16 99 Glutathione S-transferase domain protein CBSS-89187.3.peg.2957 1 T2D_unique_270813_216_406_- FIG00010600 18 5 20 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_270857_1_406_- FIG00000147 109 15 109 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_270859_241_406_+ FIG00062547 45 6 45 Superoxide reductase (EC 1.15.1.2) Oxidative stress 1.2 T2D_unique_270884_1_406_- FIG00000087 38 7 44 Histidyl-tRNA synthetase (EC 6.1.1.21) Histidine Biosynthesis 1 T2D_unique_270891_1_406_- FIG00010771 18 6 19 SusC, outer membrane protein involved in starch binding Cellulosome 1.x T2D_unique_270893_1_406_+ FIG00046929 6 2 8 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) Peptidoglycan Biosynthesis 1.9 T2D_unique_270915_1_406_- FIG00002251 16 4 17 Galactose/methyl galactoside ABC transport system, permease protein MglC (TC 3.A.1.2.3) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_270942_1_406_- FIG00001198 6 4 8 Choline-sulfatase (EC 3.1.6.6) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_270957_1_406_+ FIG00000376 6 4 8 L-asparaginase (EC 3.5.1.1) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_271006_1_405_+ FIG00014907 39 7 39 Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_271034_1_380_- FIG00000782 21 7 22 Exonuclease SbcD DNA repair, bacterial 3 T2D_unique_271061_42_405_- FIG00020363 4 3 5 ABC-type tungstate transport system, periplasmic binding protein ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_271078_1_405_- FIG00000368 48 9 49 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_271083_1_405_- FIG00000118 105 16 105 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_271086_1_405_+ FIG00000831 85 12 86 Na+/H+ antiporter NhaA type Na(+) H(+) antiporter 1 T2D_unique_271109_1_405_- FIG00003270 9 3 10 Arginine pathway regulatory protein ArgR, repressor of arg regulon Arginine Biosynthesis extended 1.0 T2D_unique_271120_1_405_- FIG00034851 37 11 43 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_271125_1_405_+ FIG00000111 70 12 71 Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) De Novo Pyrimidine Synthesis 1 T2D_unique_271132_1_405_+ FIG00001011 99 16 99 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_271157_1_405_- FIG00018396 38 8 47 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_271158_188_405_+ FIG00007134 49 7 49 FMN reductase (EC 1.5.1.29) Alkanesulfonates Utilization 20 T2D_unique_271167_30_179_+ FIG00015476 14 3 15 Stage III sporulation protein D Sporulation-related Hypotheticals 2.x T2D_unique_271171_1_405_+ FIG00000402 87 14 88 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_271194_1_405_- FIG00001347 7 3 9 Chitinase (EC 3.2.1.14) Chitin and N-acetylglucosamine utilization 2 T2D_unique_271223_211_405_- FIG00000244 26 6 27 Ketol-acid reductoisomerase (EC 1.1.1.86) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_271228_1_405_- FIG00093180 4 5 5 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_271237_1_405_- FIG00132976 39 10 40 Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33) Acetoin, butanediol metabolism 5 T2D_unique_271243_1_237_- FIG00001819 17 4 18 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_271249_1_324_- FIG00001522 24 4 25 Adenine deaminase (EC 3.5.4.2) Purine conversions 4.1118100 T2D_unique_271264_1_405_+ FIG00000088 35 6 36 Arginyl-tRNA synthetase (EC 6.1.1.19) tRNA aminoacylation, Arg 1.00 T2D_unique_271271_1_405_+ FIG00000089 7 2 8 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_271296_1_405_- FIG00451095 43 10 45 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_271305_1_405_+ FIG00000422 30 7 33 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_271308_1_405_- FIG00002742 74 14 75 Molybdenum transport ATP-binding protein ModC (TC 3.A.1.8.1) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_unique_271319_1_405_- FIG00000089 50 9 51 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_271343_1_405_+ FIG00076542 45 8 46 N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) Sialic Acid Metabolism 1.x T2D_unique_271357_212_405_- FIG00000081 29 5 30 Lipoprotein signal peptidase (EC 3.4.23.36) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_271371_1_405_+ FIG00130344 35 9 36 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_271385_1_405_+ FIG00041038 17 5 18 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_271386_1_405_- FIG00000832 24 6 28 Antiholin-like protein LrgA Murein hydrolase regulation and cell death 1.2 T2D_unique_271401_1_405_- FIG00134135 31 6 32 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_271415_1_318_+ FIG00000831 21 5 22 Na+/H+ antiporter NhaA type Na(+) H(+) antiporter 1 T2D_unique_271452_1_405_+ FIG00138960 107 15 107 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_unique_271459_1_343_+ FIG00000338 13 3 14 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) CBSS-196164.1.peg.461 2 T2D_unique_271463_1_318_+ FIG00122145 7 3 9 Ribosomal-protein-S18p-alanine acetyltransferase (EC 2.3.1.-) Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_271468_1_278_- FIG00018699 21 6 23 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_271473_1_405_- FIG00003757 5 4 6 L-arabinose transport ATP-binding protein AraG (TC 3.A.1.2.2) L-Arabinose utilization 1 T2D_unique_271485_1_405_- FIG00000636 65 12 66 Asparaginyl-tRNA synthetase (EC 6.1.1.22) tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_271492_178_405_- FIG00035175 30 5 30 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 1.1234 T2D_unique_271496_6_405_- FIG00000356 9 4 10 DNA mismatch repair protein MutS DNA repair, bacterial MutL-MutS system 1 T2D_unique_271497_1_405_- FIG00038343 7 2 9 Alfa-L-rhamnosidase (EC 3.2.1.40) L-rhamnose utilization 1 T2D_unique_271526_1_405_- FIG00846773 11 4 16 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_271554_1_405_- FIG00080955 83 15 84 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_271574_1_405_- FIG00004078 55 9 57 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_271581_1_405_- FIG00000482 19 6 21 UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) Sialic Acid Metabolism 1.x T2D_unique_271585_70_405_- FIG00000149 4 3 5 Phosphoserine phosphatase (EC 3.1.3.3) Serine Biosynthesis 2.x T2D_unique_271595_1_249_- FIG00000118 58 9 58 Enolase (EC 4.2.1.11) Serine-glyoxylate cycle 1 T2D_unique_271619_178_405_+ FIG00000028 52 8 52 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_271636_1_159_- FIG00035634 27 5 27 Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) DNA Repair Base Excision 4 T2D_unique_271636_172_405_- FIG00000404 60 9 60 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_271645_1_190_+ FIG00132726 44 7 44 PTS system, fructose-specific IIB component (EC 2.7.1.69) Fructose utilization 1 T2D_unique_271646_1_405_- FIG00000132 64 12 67 Aspartokinase (EC 2.7.2.4) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_271650_1_405_- FIG00001676 11 3 13 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_271654_1_186_+ FIG00719736 11 3 15 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_271678_1_312_- FIG00000401 49 9 50 1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC 1.1.1.267) Isoprenoid Biosynthesis 2.x T2D_unique_271681_1_405_+ FIG01260980 3 2 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_271682_1_405_+ 5 4 7 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_271694_241_405_+ FIG00133144 3 2 4 Muconate cycloisomerase (EC 5.5.1.1) Muconate lactonizing enzyme family 1 T2D_unique_271695_1_405_+ FIG00001402 8 3 9 Helicase loader DnaI DNA-replication 4 T2D_unique_271700_1_405_- FIG01956356 6 3 8 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) Mannose Metabolism 2.0 T2D_unique_271718_1_354_+ FIG00028203 37 9 38 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_271740_1_405_+ FIG00018561 98 15 98 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_271761_1_374_+ FIG00006151 25 5 26 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_271793_1_405_+ FIG00002541 4 3 6 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_271801_1_257_- FIG00000464 13 5 14 Ribosome small subunit-stimulated GTPase EngC A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_271819_268_405_- FIG00081563 29 5 29 N-acetylmannosamine kinase (EC 2.7.1.60) Sialic Acid Metabolism 1.x T2D_unique_271823_1_405_- FIG00080231 123 16 123 Ribosome protection-type tetracycline resistance related proteins, group 2 Translation elongation factor G family 4 T2D_unique_271833_31_405_- FIG00000402 4 2 5 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_271845_1_405_+ FIG00000015 46 7 48 Signal peptidase I (EC 3.4.21.89) Signal peptidase 3 T2D_unique_271865_1_405_- FIG00002268 91 14 91 ATP-dependent DNA ligase (EC 6.5.1.1) clustered with Ku protein, LigD DNA Repair Base Excision 4 T2D_unique_271886_1_333_+ FIG00103661 42 8 43 Transcriptional regulator, MerR family, near polyamine transporter Polyamine Metabolism 2 T2D_unique_271891_1_405_+ FIG00000372 58 11 59 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_271898_1_405_+ FIG00043723 103 14 103 Aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_271905_1_292_- FIG00000450 66 10 66 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_271964_1_405_- FIG01304601 112 16 112 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_271973_1_405_+ FIG00000405 47 9 49 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_271975_173_405_+ FIG00003881 11 3 13 RNA polymerase sporulation specific sigma factor SigG Transcription initiation, bacterial sigma factors 1 T2D_unique_271979_1_379_- FIG00000279 8 2 9 GTPase and tRNA-U34 5-formylation enzyme TrmE Cell Division Subsystem including YidCD 1 T2D_unique_271986_115_405_- FIG00000023 11 2 12 Transaldolase (EC 2.2.1.2) Fructose utilization 1 T2D_unique_272000_1_405_+ FIG00022300 4 3 6 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_272003_25_405_- FIG00051957 89 14 90 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_272005_1_405_- FIG00000453 61 10 63 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) One-carbon metabolism by tetrahydropterines 5 T2D_unique_272019_1_221_+ FIG00007041 6 3 8 Chemotaxis protein CheV (EC 2.7.3.-) Bacterial Chemotaxis 9 T2D_unique_272038_1_404_+ FIG00001670 101 16 101 Adenine-specific methyltransferase (EC 2.1.1.72) CBSS-257314.1.peg.752 1,x T2D_unique_272044_1_404_+ FIG00148704 85 13 86 tRNA-dependent lipid II--L-alanine ligase tRNA-dependent amino acid transfers 1 T2D_unique_272046_1_404_- FIG00007960 30 6 32 Glycosyltransferase CBSS-258594.1.peg.3339 1 T2D_unique_272048_1_404_+ FIG00009682 7 5 8 Phosphoglucosamine mutase (EC 5.4.2.10) Sialic Acid Metabolism 1.x T2D_unique_272061_1_404_- FIG00000474 13 5 15 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_272069_1_404_- FIG00000001 4 2 5 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_272075_1_404_+ FIG00000085 19 5 20 Isoleucyl-tRNA synthetase (EC 6.1.1.5) tRNA aminoacylation, Ile 1.00 T2D_unique_272088_1_404_+ FIG01260980 3 3 6 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_272089_1_257_- FIG00001489 3 2 4 ribosomal protein L7Ae family protein Transcription factors bacterial 1 T2D_unique_272102_1_404_- FIG00000494 13 5 15 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_272107_1_404_- FIG00001469 55 12 56 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_272117_1_404_+ FIG00000114 30 7 31 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_272140_1_290_- FIG00000491 6 2 7 Queuosine Biosynthesis QueC ATPase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_272142_1_404_+ FIG00080955 19 7 20 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_unique_272146_118_404_- FIG00001166 19 6 21 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_272148_1_404_- FIG00001548 20 3 21 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_272153_1_404_- FIG00000402 91 15 91 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_272190_1_130_+ FIG00000387 8 2 11 Nicotinate phosphoribosyltransferase (EC 2.4.2.11) Redox-dependent regulation of nucleus processes 2 T2D_unique_272190_148_404_+ FIG00000351 15 4 16 Glutamate 5-kinase (EC 2.7.2.11) Proline Synthesis 1 T2D_unique_272209_1_404_+ FIG00004078 5 5 6 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_272214_1_404_+ FIG00000114 68 12 70 Leucyl-tRNA synthetase (EC 6.1.1.4) tRNA aminoacylation, Leu 1.00 T2D_unique_272235_1_272_+ FIG00000069 14 4 15 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_272240_13_404_+ FIG00000552 22 4 24 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_272259_26_404_- FIG00001385 7 3 9 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_272270_235_404_+ FIG00000329 13 3 14 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_272296_1_404_+ FIG00143531 33 9 35 Penicillin-binding protein 2 (PBP-2) Peptidoglycan Biosynthesis 1.9 T2D_unique_272299_1_279_+ FIG00000089 21 6 22 Adenylate kinase (EC 2.7.4.3) Purine conversions 4.1118100 T2D_unique_272319_1_404_+ FIG00061131 3 2 9 Xylose ABC transporter, ATP-binding component Xylose utilization 1 T2D_unique_272321_1_404_- FIG00035701 85 14 86 Tyrosine-protein kinase EpsD (EC 2.7.10.2) Exopolysaccharide Biosynthesis 1.0 T2D_unique_272323_1_404_- FIG00046358 39 8 46 Transport ATP-binding protein CydC Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_272330_1_404_+ FIG00000402 14 7 16 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_272334_142_404_+ FIG00000219 62 10 62 LSU ribosomal protein L22p (L17e) Ribosome LSU bacterial 9 T2D_unique_272342_1_404_- FIG00002194 6 2 8 FIG146085: 3'-to-5' oligoribonuclease A, Bacillus type CBSS-138119.3.peg.2719 9 T2D_unique_272343_260_404_- FIG00136866 14 3 15 Electron transfer flavoprotein, alpha subunit Acetyl-CoA fermentation to Butyrate A T2D_unique_272347_1_404_- FIG01955782 86 14 86 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_272353_1_404_+ FIG00006997 34 6 37 Ferric iron ABC transporter, permease protein Iron acquisition in Streptococcus 1 T2D_unique_272405_1_404_+ FIG00129616 19 8 21 GTP-binding protein EngA Universal GTPases 2 T2D_unique_272413_1_404_+ FIG00000672 25 8 27 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_272442_231_404_+ FIG01290653 9 2 10 Phosphate regulon transcriptional regulatory protein PhoB (SphR) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_272452_1_404_- FIG01955782 101 14 101 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_272459_1_231_+ FIG00000047 11 3 12 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_272472_1_404_- FIG00000235 30 6 32 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_272474_1_404_+ FIG00001635 90 14 90 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_272545_1_217_+ FIG00000157 30 5 31 2-isopropylmalate synthase (EC 2.3.3.13) Branched-Chain Amino Acid Biosynthesis 8 T2D_unique_272548_1_404_- FIG00007328 34 7 35 Sortase A, LPXTG specific Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_272553_1_290_+ FIG00000221 50 8 51 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) Peptidoglycan Biosynthesis 1.9 T2D_unique_272556_1_404_+ FIG00000494 3 2 4 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_272566_1_404_- FIG00451095 16 4 17 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_272575_1_180_- FIG00002689 9 2 10 Electron transport complex protein RnfG Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_272577_1_404_- FIG00002020 28 7 29 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_272586_1_404_+ FIG00000056 67 13 69 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_272587_1_404_- FIG00024930 67 13 68 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_272613_182_404_+ FIG00001563 6 2 7 Preprotein translocase subunit SecG (TC 3.A.5.1.1) Murein hydrolase regulation and cell death 1.2 T2D_unique_272624_1_404_- FIG00001647 7 2 10 Maltodextrin glucosidase (EC 3.2.1.20) Maltose and Maltodextrin Utilization 1.x T2D_unique_272655_1_404_+ FIG00134135 3 2 4 Glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21) Glycogen metabolism 3 T2D_unique_272658_1_404_+ FIG00007514 10 3 12 Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) Polyamine Metabolism 2 T2D_unique_272661_1_404_+ FIG00000069 43 11 45 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_272671_112_404_+ FIG01266244 37 8 38 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_272679_1_404_+ FIG00001328 30 7 32 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein) (EC 1.4.4.2) Lipoic acid metabolism 5.0 T2D_unique_272693_218_404_+ FIG00000148 16 4 17 SSU ribosomal protein S4p (S9e) CBSS-393130.3.peg.794 2 T2D_unique_272695_1_404_- FIG00000025 18 5 20 Cell division protein FtsW cell division cluster containing FtsQ 1 T2D_unique_272698_1_248_+ FIG00045144 5 2 9 Methionine ABC transporter permease protein Methionine Degradation 3 T2D_unique_272702_1_404_+ FIG01260980 13 5 15 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_272706_1_170_- FIG00001029 18 4 19 Alkyl hydroperoxide reductase protein F (EC 1.6.4.-) Thioredoxin-disulfide reductase 2 T2D_unique_272732_1_341_- FIG01260980 80 13 81 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_272733_1_155_+ FIG00011114 6 2 7 Phosphate transport ATP-binding protein PstB (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_272743_102_404_+ FIG00001548 56 9 57 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_272757_1_404_- FIG00000147 68 11 69 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_272815_1_402_+ FIG00041038 52 9 54 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_272825_1_404_- FIG00005283 50 10 52 Putative DNA-binding protein in cluster with Type I restriction-modification system Restriction-Modification System 3.x T2D_unique_272859_1_404_+ FIG01260980 112 15 112 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_272862_1_404_+ FIG00133229 28 7 29 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) Allantoin Utilization X T2D_unique_272885_1_404_- FIG00437351 5 5 8 [FeFe]-hydrogenase maturation protein HydE FeFe hydrogenase maturation 1 T2D_unique_272901_1_404_- FIG00000793 51 12 54 Xylulose kinase (EC 2.7.1.17) Xylose utilization 1 T2D_unique_272932_1_404_+ FIG00028203 12 5 17 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_272943_1_404_+ FIG00000055 78 13 79 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_272969_1_404_+ FIG00011659 45 8 46 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_273015_1_403_- FIG00000835 15 5 19 NAD-dependent malic enzyme (EC 1.1.1.38) Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_273030_1_281_+ FIG00074225 3 2 5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) Isoprenoid Biosynthesis 2.x T2D_unique_273039_1_380_+ FIG00000897 79 13 84 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_273040_1_403_- FIG00002489 9 4 11 Spore germination protein GerKA Spore germination 1 T2D_unique_273050_1_403_+ FIG00006955 3 3 5 Tyrosine-protein kinase Wzc (EC 2.7.10.2) CBSS-258594.1.peg.3339 1 T2D_unique_273096_1_403_+ FIG00000289 31 6 32 tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) Polyadenylation bacterial 2 T2D_unique_273104_18_403_+ FIG00000098 48 8 49 Phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_273127_1_223_+ FIG00095112 5 3 7 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) DNA-replication 4 T2D_unique_273152_17_403_- FIG00000047 95 14 95 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_273156_98_403_- FIG00001819 23 7 24 Uridylate kinase (EC 2.7.4.-) CBSS-312309.3.peg.1965 1 T2D_unique_273207_1_403_+ FIG00000834 12 5 14 Phosphoenolpyruvate carboxykinase [ATP] (EC 4.1.1.49) Serine-glyoxylate cycle 1 T2D_unique_273212_1_403_- FIG00001188 9 3 10 Aminoacyl-histidine dipeptidase (Peptidase D) (EC 3.4.13.3) EC 3.4.13.- Dipeptidases 1 T2D_unique_273213_1_389_+ FIG00000263 92 14 92 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_273221_1_403_+ FIG00024930 48 10 49 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_273227_44_403_- FIG00006542 8 2 9 FIG006542: Phosphoesterase CBSS-257314.1.peg.676 4.x T2D_unique_273230_92_403_- FIG00031250 13 4 14 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_273258_1_403_+ FIG00000056 69 13 70 Heat shock protein 60 family chaperone GroEL GroEL GroES 9 T2D_unique_273289_1_403_- FIG00002020 49 9 50 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_273303_1_403_- FIG00006463 9 4 10 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_unique_273328_1_403_+ FIG00000404 38 9 40 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_273360_1_403_- FIG00000716 23 6 25 Homoserine O-acetyltransferase (EC 2.3.1.31) Methionine Biosynthesis 8 T2D_unique_273378_1_252_+ FIG00010600 11 3 12 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_273412_1_403_+ FIG00138960 108 16 108 Autolysis histidine kinase LytS Murein hydrolase regulation and cell death 1.2 T2D_unique_273447_1_403_- FIG00030191 72 12 73 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_273462_249_403_+ FIG00055520 34 6 34 Regulation of D-alanyl-lipoteichoic acid biosynthesis, DltR Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_273465_1_403_- FIG00000659 27 6 29 Purine nucleoside phosphorylase (EC 2.4.2.1) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_273481_1_403_+ FIG00000301 107 15 107 Argininosuccinate synthase (EC 6.3.4.5) Arginine Biosynthesis extended 1.0 T2D_unique_273491_1_403_+ FIG00002034 5 4 7 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_273502_1_403_- FIG00000223 5 3 7 LSU ribosomal protein L2p (L8e) Ribosome LSU bacterial 9 T2D_unique_273506_1_403_+ FIG00000448 9 3 10 Glycyl-tRNA synthetase beta chain (EC 6.1.1.14) tRNA aminoacylation, Gly 3 T2D_unique_273515_1_403_- FIG00041038 34 6 35 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_273517_1_403_+ FIG00000309 5 3 6 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_273542_62_403_- FIG00000368 67 11 70 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_273547_1_297_+ FIG00000328 15 7 17 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) DNA repair, bacterial 3 T2D_unique_273562_101_403_- FIG00846773 32 6 33 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_273578_1_344_+ FIG00058830 9 5 11 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_273583_1_403_+ FIG00003845 63 10 64 Transcriptional regulator, ArsR family cAMP signaling in bacteria 4.1007 T2D_unique_273593_1_403_- FIG00000721 20 6 22 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_273600_67_403_- FIG00000422 10 4 11 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_273601_70_285_- FIG00002141 53 8 54 Competence protein CoiA Gram Positive Competence 3100 T2D_unique_273605_1_403_- FIG00011659 12 3 14 Formate dehydrogenase-O, major subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_273614_1_403_- FIG00000402 3 3 5 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_273625_141_403_+ FIG00028476 64 9 64 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_273627_1_403_- FIG00001548 8 2 9 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_273632_1_403_- FIG00000147 42 10 44 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_273657_1_403_- FIG00000269 31 7 33 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_273659_83_403_+ FIG00002148 10 4 12 Aspartate carbamoyltransferase regulatory chain (PyrI) De Novo Pyrimidine Synthesis 1 T2D_unique_273672_1_403_+ FIG00000329 64 11 65 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_273683_1_403_+ FIG00010661 112 16 112 Alpha-L-Rha alpha-1,2-L-rhamnosyltransferase/alpha-L-Rha alpha-1,3-L- rhamnosyltransferase (EC 2.4.1.-) Rhamnose containing glycans 4.1 T2D_unique_273698_1_403_- FIG01960451 7 2 9 Cell wall surface anchor family protein Sortase 1.12 T2D_unique_273734_1_287_- FIG00002117 15 3 17 L-arabinose isomerase (EC 5.3.1.4) L-Arabinose utilization 1 T2D_unique_273737_1_403_- FIG00000415 101 15 101 Ribose 5-phosphate isomerase A (EC 5.3.1.6) Glycolate, glyoxylate interconversions ? T2D_unique_273746_1_403_- FIG00000402 41 8 42 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_273751_1_403_- FIG00000672 91 15 91 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_273753_36_403_- FIG00000205 59 10 60 LSU ribosomal protein L9p CBSS-262719.3.peg.410 1 T2D_unique_273759_138_403_+ FIG01583289 22 6 22 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) Inositol catabolism 5.x T2D_unique_273765_1_403_+ FIG00000131 106 16 106 Guanylate kinase (EC 2.7.4.8) CBSS-323097.3.peg.2594 1 T2D_unique_273771_1_379_+ FIG00023946 17 5 18 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_273778_156_403_- FIG00000474 6 3 8 Histidinol-phosphate aminotransferase (EC 2.6.1.9) Histidine Biosynthesis 1 T2D_unique_273800_1_403_+ FIG00001550 12 4 14 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_273803_1_403_+ FIG00002716 11 5 12 Ribosomal small subunit pseudouridine synthase A (EC 4.2.1.70) Pseudouridine Metabolism 9 T2D_unique_273809_1_256_+ FIG01266244 7 3 9 Ribosomal protein S12p Asp88 (E. coli) methylthiotransferase Ribosomal protein S12p Asp methylthiotransferase 1 T2D_unique_273817_1_403_+ FIG00001676 34 6 35 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_273825_1_207_- FIG00001882 8 2 8 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_273841_1_403_- FIG00022300 3 2 5 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_273842_1_403_+ FIG00008490 87 13 88 NAD-dependent protein deacetylase of SIR2 family Redox-dependent regulation of nucleus processes 2 T2D_unique_273848_1_403_- FIG00037431 6 3 7 DNA repair protein RadC DNA repair, bacterial 3 T2D_unique_273854_1_403_- FIG00000075 11 6 12 NAD kinase (EC 2.7.1.23) CBSS-222523.1.peg.1311 1 T2D_unique_273858_1_403_+ FIG00016514 18 5 20 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_273859_1_403_- FIG00000080 61 13 62 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_273870_164_403_+ FIG00000214 30 7 31 LSU ribosomal protein L19p Ribosome LSU bacterial 9 T2D_unique_273888_1_403_- FIG00026137 21 6 23 Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_273898_1_403_- FIG00021289 31 9 32 ATP-dependent DNA helicase RecG (EC 3.6.1.-) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_273901_1_403_+ FIG00000422 96 15 96 ATP-dependent DNA helicase RecQ DNA-replication 4 T2D_unique_273904_1_403_+ FIG00007658 20 5 22 Fumarylacetoacetate hydrolase family protein Salicylate and gentisate catabolism 2 T2D_unique_273920_75_403_- FIG00043527 81 13 81 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_273924_1_403_+ FIG00034293 26 7 28 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_273936_1_274_- FIG00000824 15 4 16 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_273946_1_403_+ FIG00012267 10 5 29 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_273953_1_236_+ FIG00001436 39 8 39 GlpG protein (membrane protein of glp regulon) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_273968_1_234_+ FIG00007339 10 2 12 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_unique_273982_1_402_- FIG00001579 100 16 100 D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13) D-Alanyl Lipoteichoic Acid Biosynthesis 2.0 T2D_unique_273990_1_402_- FIG00000402 52 10 53 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_273993_219_402_+ FIG00000036 41 6 41 Methionine aminopeptidase (EC 3.4.11.18) Translation termination factors bacterial 1.13 T2D_unique_273996_107_402_- FIG00022300 73 11 73 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_274001_1_402_+ FIG00000268 47 8 52 GTP-binding protein TypA/BipA Universal GTPases 2 T2D_unique_274028_1_246_+ FIG00000402 18 5 19 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_274033_1_402_+ FIG00048507 114 16 114 Catabolite control protein A HPr catabolite repression system 1 T2D_unique_274041_1_402_- FIG00003810 23 4 25 Arginase (EC 3.5.3.1) Arginine and Ornithine Degradation 1.34 T2D_unique_274045_1_402_+ FIG00002130 27 6 28 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_274048_1_402_- FIG00034851 10 5 11 RND efflux system, inner membrane transporter CmeB Multidrug Resistance Efflux Pumps 1.12 T2D_unique_274059_94_402_+ FIG00001088 51 8 52 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_274070_1_402_- FIG00000421 22 4 23 Diaminopimelate epimerase (EC 5.1.1.7) CBSS-84588.1.peg.1247 1 T2D_unique_274098_161_402_+ FIG00000309 12 3 13 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) Glutaredoxins 1 T2D_unique_274105_1_402_+ FIG00018201 114 16 114 HflC protein Hfl operon 1.111 T2D_unique_274142_1_402_- FIG00146581 78 12 79 Beta-galactosidase 3 Galactosylceramide and Sulfatide metabolism 7 T2D_unique_274151_1_402_+ FIG00001548 65 11 66 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_274160_1_402_+ FIG00000245 80 14 82 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_274163_61_402_- FIG00000011 12 3 13 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_274172_144_402_- FIG00001548 24 5 28 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_274199_1_402_+ FIG00000245 32 9 33 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_274202_1_173_- FIG00001550 7 2 9 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) CBSS-257314.1.peg.676 4.x T2D_unique_274213_1_402_+ FIG00137509 22 5 23 Alpha-amylase (Neopullulanase) SusA (EC 3.2.1.135) Cellulosome 1.x T2D_unique_274217_1_402_+ FIG00000895 49 13 52 Alanine dehydrogenase (EC 1.4.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_274223_1_402_- FIG00041038 11 3 13 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_274238_5_373_+ FIG00000450 17 6 18 Deoxyribose-phosphate aldolase (EC 4.1.2.4) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_274241_1_314_- FIG00000055 52 9 53 Tryptophanyl-tRNA synthetase (EC 6.1.1.2) tRNA aminoacylation, Trp 1.00 T2D_unique_274247_1_402_+ FIG00000395 32 7 34 A/G-specific adenine glycosylase (EC 3.2.2.-) CBSS-261594.1.peg.788 1 T2D_unique_274251_1_402_- FIG00132839 19 5 20 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_274254_1_402_- FIG00000402 85 14 86 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_274263_1_402_- FIG00001618 59 11 59 Oxaloacetate decarboxylase alpha chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_274269_1_266_+ FIG00018457 6 4 8 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_274321_32_402_- FIG00077620 5 3 6 Single-stranded DNA-binding protein DNA repair, bacterial UmuCD system 3 T2D_unique_274359_1_205_+ FIG00012945 4 3 6 Ribose ABC transport system, permease protein RbsC (TC 3.A.1.2.1) D-ribose utilization A.123 T2D_unique_274367_1_159_+ FIG00019890 32 5 33 Predicted amino-acid acetyltransferase (EC 2.3.1.1) complementing ArgA function in Arginine Biosynthesis pathway Arginine Biosynthesis extended 1.0 T2D_unique_274385_1_336_+ FIG00010738 5 5 6 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) Histidine Biosynthesis 1 T2D_unique_274403_1_402_- FIG00026918 6 3 7 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_274417_1_402_+ FIG00084105 27 8 28 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Isoprenoid Biosynthesis 2.x T2D_unique_274424_1_402_+ FIG00001347 16 3 18 Chitinase (EC 3.2.1.14) Chitin and N-acetylglucosamine utilization 2 T2D_unique_274429_1_402_- FIG00719736 27 5 29 Aspartate aminotransferase (EC 2.6.1.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_274460_1_402_+ FIG00041382 69 10 70 Anaerobic dehydrogenases, typically selenocysteine-containing Anaerobic respiratory reductases 3 T2D_unique_274472_104_402_+ FIG01955774 12 3 13 Prophage Clp protease-like protein cAMP signaling in bacteria 4.1007 T2D_unique_274495_24_402_- FIG00001366 20 7 22 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_274496_1_402_- FIG00000365 52 10 55 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_274537_1_402_- FIG00001401 4 3 7 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_274539_1_402_- FIG00000552 9 3 20 Cell division protein FtsX CBSS-393121.3.peg.2760 1 T2D_unique_274542_1_402_+ FIG00001469 6 5 8 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_274556_1_292_+ FIG00043527 10 4 11 Neuraminidase NanP Galactosylceramide and Sulfatide metabolism 7 T2D_unique_274575_119_402_+ FIG00001675 13 5 26 Oxaloacetate decarboxylase beta chain (EC 4.1.1.3) Na+ translocating decarboxylases and related biotin-dependent enzymes 1 T2D_unique_274578_1_361_+ FIG00001402 70 11 74 Helicase loader DnaI DNA-replication 4 T2D_unique_274585_1_402_+ FIG00000145 67 13 69 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_274610_1_402_+ FIG00000465 17 5 18 Lipoate-protein ligase A Dehydrogenase complexes 1.2100 T2D_unique_274640_1_402_+ FIG00034392 73 12 75 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) Peptidoglycan Biosynthesis 1.9 T2D_unique_274643_1_402_- FIG00009265 28 5 32 L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) Selenocysteine metabolism 1.1 T2D_unique_274670_1_270_- FIG00020613 19 4 21 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) Purine conversions 4.1118100 T2D_unique_274689_1_402_+ FIG00000350 3 2 4 D-alanine--D-alanine ligase (EC 6.3.2.4) Peptidoglycan Biosynthesis 1.9 T2D_unique_274700_1_379_- FIG00000641 20 5 21 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_unique_274702_1_402_+ FIG00061832 27 8 36 Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) Sialic Acid Metabolism 1.x T2D_unique_274718_1_402_- FIG00000504 93 15 94 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_274754_1_402_+ FIG00000391 99 15 99 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) Polyadenylation bacterial 2 T2D_unique_274772_1_242_+ FIG00000040 51 9 52 Serine hydroxymethyltransferase (EC 2.1.2.1) Serine Biosynthesis 2.x T2D_unique_274797_1_402_+ FIG00003788 27 7 28 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_274808_1_378_- FIG00026750 42 8 44 Predicted glucose transporter in maltodextrin utilization gene cluster Maltose and Maltodextrin Utilization 1.x T2D_unique_274809_1_264_- FIG00001062 58 8 59 Agmatine deiminase (EC 3.5.3.12) Polyamine Metabolism 2 T2D_unique_274811_1_402_- FIG00000102 59 10 60 Translation initiation factor 2 Translation initiation factors bacterial 1.111 T2D_unique_274820_44_402_+ FIG00138182 8 2 9 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_274842_1_402_+ FIG00451095 64 11 65 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_274844_1_402_- FIG00016514 13 4 14 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_274848_1_152_+ FIG00024930 9 2 10 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_274848_178_402_+ FIG00001968 14 2 15 PTS system, mannose-specific IIB component (EC 2.7.1.69) Sialic Acid Metabolism 1.x T2D_unique_274870_210_402_- FIG00081311 40 7 40 rubredoxin-oxygen oxidoreductase Rubrerythrin 2 T2D_unique_274888_1_402_+ FIG00000163 8 4 13 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_274890_1_283_+ FIG00002049 64 10 64 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_274904_56_402_- FIG00000234 41 8 42 RecA protein CBSS-257314.1.peg.676 4.x T2D_unique_274928_1_402_+ FIG01260980 67 12 68 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_274947_1_402_- FIG00002020 47 9 48 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_274950_236_402_- FIG00000329 7 2 8 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_274960_1_402_+ FIG00023369 65 13 66 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_274964_1_402_- FIG00023946 5 4 7 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_274982_1_146_- FIG00000263 19 4 20 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_275026_1_401_+ FIG00000986 39 9 40 L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) L-Arabinose utilization 1 T2D_unique_275083_211_401_+ FIG00001385 10 3 11 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_unique_275099_1_401_+ FIG00451095 11 6 16 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_275103_1_401_+ FIG00025216 85 14 85 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_275111_1_401_- FIG00554193 24 8 25 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_275122_1_401_+ FIG00003174 11 3 12 Alpha-xylosidase (EC 3.2.1.-) Xylose utilization 1 T2D_unique_275132_1_401_- FIG00001366 14 6 15 1-phosphofructokinase (EC 2.7.1.56) Fructose utilization 1 T2D_unique_275136_1_128_+ FIG00000273 5 3 6 Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) riboflavin to FAD 1 T2D_unique_275141_1_401_+ FIG00002049 13 5 14 Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7 T2D_unique_275166_46_401_- FIG00025213 7 2 9 Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr, subfamily A1 (as in PMID19099556) Cell envelope-associated LytR-CpsA-Psr transcriptional attenuators 1 T2D_unique_275167_208_401_+ FIG00005112 13 3 15 Trehalose synthase (EC 5.4.99.16) Trehalose Biosynthesis 1.2 T2D_unique_275184_231_401_- FIG00000531 18 4 19 Putative stomatin/prohibitin-family membrane protease subunit YbbK CBSS-316057.3.peg.659 1 T2D_unique_275188_1_401_+ FIG00005243 7 3 10 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_275191_1_401_+ FIG01954097 37 7 39 Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_275200_1_360_+ FIG00000404 104 14 104 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_275220_1_280_- FIG00000463 24 7 25 Quinolinate synthetase (EC 2.5.1.72) Cobalt-zinc-cadmium resistance 1.26 T2D_unique_275229_1_310_+ FIG00026044 17 4 18 Serine protease precursor MucD/AlgY associated with sigma factor RpoE Transcription initiation, bacterial sigma factors 1 T2D_unique_275255_1_401_- FIG00022976 8 5 12 Electron transport complex protein RnfD Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_275260_1_401_- FIG00127025 9 3 10 Substrate-specific component QueT (COG4708) of predicted queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_275281_1_401_+ FIG00000494 9 5 11 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_275283_1_401_+ FIG00000134 16 6 19 Threonine synthase (EC 4.2.3.1) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_275288_1_401_- FIG00028694 98 14 98 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) Fructose utilization 1 T2D_unique_275324_199_401_- FIG00000494 18 4 20 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_275331_1_401_- FIG00036406 17 6 19 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_275354_1_347_- FIG01304892 16 5 17 Betaine aldehyde dehydrogenase (EC 1.2.1.8) Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_275367_175_401_- FIG00000028 53 8 53 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) Proteasome bacterial 1 T2D_unique_275375_1_298_+ FIG00000226 46 8 47 GTP cyclohydrolase I (EC 3.5.4.16) type 1 Zinc regulated enzymes 1 T2D_unique_275385_1_401_- FIG00036406 5 2 9 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_275399_1_349_- FIG00001642 3 2 4 Alanine racemase (EC 5.1.1.1) Pyruvate Alanine Serine Interconversions 5.0 T2D_unique_275418_1_401_- FIG00010844 4 3 6 Flavodoxin Flavodoxin 1 T2D_unique_275421_1_401_- FIG00060517 112 16 112 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_275422_1_401_+ FIG00000441 29 7 30 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_275455_1_256_- FIG00000245 7 3 8 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_275482_1_242_- FIG00014903 16 4 17 Outer membrane receptor proteins, mostly Fe transport Hemin transport system 1 T2D_unique_275496_1_401_- FIG01304279 4 3 4 Di/tripeptide permease DtpT Proton-dependent Peptide Transporters 1 T2D_unique_275522_32_401_+ FIG00000680 23 5 25 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_275558_1_401_+ FIG00052730 9 3 11 ATP-dependent nuclease, subunit B ATP-dependent Nuclease 1 T2D_unique_275569_1_401_- FIG00007957 75 12 76 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_unique_275583_1_401_- FIG00000242 67 11 68 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_275608_1_242_- FIG00067248 8 3 10 Acetate kinase (EC 2.7.2.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_275618_1_401_+ FIG00001896 5 2 6 LSU ribosomal protein L25p Ribosome LSU bacterial 9 T2D_unique_275620_1_390_+ FIG00010600 44 10 45 Xaa-Pro aminopeptidase (EC 3.4.11.9) EC 3.4.11.- Aminopeptidases 1 T2D_unique_275626_1_401_+ FIG00051439 16 3 18 DNA ligase (EC 6.5.1.2) CBSS-393121.3.peg.1913 1 T2D_unique_275648_147_401_- FIG00002652 31 5 32 CDP-glycerol: N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_275668_1_401_+ FIG00006868 9 2 10 hypothetical protein BH3604 CBSS-393121.3.peg.2760 1 T2D_unique_275705_1_282_+ FIG00000402 39 7 40 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_275717_1_401_- FIG00000116 33 7 34 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_275735_1_401_+ FIG00004876 26 7 28 Acetaldehyde dehydrogenase, ethanolamine utilization cluster Fermentations: Mixed acid 1 T2D_unique_275752_1_253_- FIG00001168 6 3 7 Acetylornithine aminotransferase (EC 2.6.1.11) Arginine Biosynthesis extended 1.0 T2D_unique_275756_1_306_+ FIG01312219 11 5 12 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase (EC 4.2.1.-) Acetoin, butanediol metabolism 5 T2D_unique_275767_1_365_+ FIG00001067 54 11 55 Rubrerythrin Oxidative stress 1.2 T2D_unique_275779_1_296_+ FIG00018176 26 6 27 Phospholipid-lipopolysaccharide ABC transporter N-linked Glycosylation in Bacteria 2.0 T2D_unique_275780_1_401_+ FIG00047509 34 7 36 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_275786_1_334_+ FIG00134889 15 3 16 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_275789_1_401_+ FIG00006128 102 16 102 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_275796_1_322_- FIG00052605 13 8 27 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_275822_1_401_- FIG00006128 7 2 9 Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_unique_275830_232_401_+ FIG00016061 25 5 25 L-lactate permease Lactate utilization 3 T2D_unique_275842_1_401_+ FIG00003757 5 2 6 L-arabinose transport ATP-binding protein AraG (TC 3.A.1.2.2) L-Arabinose utilization 1 T2D_unique_275872_1_401_+ FIG01955844 11 3 13 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_275903_1_164_+ FIG00008752 23 4 23 ComF operon protein C Gram Positive Competence 3100 T2D_unique_275936_252_401_+ FIG00000645 21 4 22 Glucosamine-6-phosphate deaminase (EC 3.5.99.6) Sialic Acid Metabolism 1.x T2D_unique_275942_84_401_+ FIG00006551 55 11 55 Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_275944_169_401_+ FIG00000032 11 2 13 Dihydroorotase (EC 3.5.2.3) De Novo Pyrimidine Synthesis 1 T2D_unique_275976_1_401_+ FIG00000264 61 13 62 LSU ribosomal protein L1p (L10Ae) Ribosome LSU bacterial 9 T2D_unique_275977_1_401_- FIG00007373 108 15 109 Two-component response regulator yesN, associated with MetSO reductase Peptide methionine sulfoxide reductase 1 T2D_unique_275992_1_401_+ FIG00041038 34 9 37 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_276008_1_401_- FIG00000358 28 7 29 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) Arginine Biosynthesis extended 1.0 T2D_unique_276012_10_201_- FIG00002761 36 7 37 DedA protein Uptake of selenate and selenite 1.1 T2D_unique_276016_214_401_- FIG00001036 24 5 25 Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF, TadA subfamily Widespread colonization island 2 T2D_unique_276017_1_401_+ FIG00000962 114 16 114 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) Purine Utilization 1 T2D_unique_276018_1_401_- FIG00058830 33 7 36 6-phosphofructokinase (EC 2.7.1.11) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_276029_1_197_- FIG00138538 49 7 49 Aminomethyltransferase (glycine cleavage system T protein) (EC 2.1.2.10) Glycine and Serine Utilization 1.12 T2D_unique_276058_89_400_+ FIG00132666 75 11 75 Hypothetical similar to thiamin biosynthesis lipoprotein ApbE Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_276067_1_400_- FIG00001396 106 16 106 Alpha-acetolactate decarboxylase (EC 4.1.1.5) Acetoin, butanediol metabolism 5 T2D_unique_276083_42_400_+ FIG00014849 6 3 7 Hydrolase (HAD superfamily), YqeK NAD and NADP cofactor biosynthesis global E T2D_unique_276117_1_400_+ FIG00000069 3 4 5 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_276120_113_400_+ FIG00001080 4 2 6 Membrane fusion component of tripartite multidrug resistance system Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 1 T2D_unique_276123_1_400_+ FIG00000695 110 16 110 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_276156_1_343_- FIG00016836 9 3 11 Transcription termination protein NusB Transcription factors bacterial 1 T2D_unique_276170_110_400_- FIG00000897 5 2 6 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_unique_276205_1_400_- FIG00000368 49 10 61 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) dTDP-rhamnose synthesis 2.0 T2D_unique_276210_1_288_- FIG00000456 9 4 10 Glycerate kinase (EC 2.7.1.31) Allantoin Utilization X T2D_unique_276222_1_400_+ FIG00000175 10 4 11 Thymidylate kinase (EC 2.7.4.9) CBSS-393133.3.peg.2787 1 T2D_unique_276239_112_400_- FIG00000017 15 4 16 Peptide deformylase (EC 3.5.1.88) CBSS-89187.3.peg.2957 1 T2D_unique_276244_1_400_+ FIG00018035 85 13 85 Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter ECF class transporters 345678 T2D_unique_276253_93_400_+ FIG00011468 16 6 18 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_276256_1_400_- FIG01297554 29 7 31 Ferredoxin 3 fused to uncharacterized domain Nitrosative stress 4 T2D_unique_276265_1_400_+ FIG00052605 58 12 59 Cardiolipin synthetase (EC 2.7.8.-) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_276282_136_400_+ FIG00000555 6 3 8 Undecaprenyl-diphosphatase (EC 3.6.1.27) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_276284_156_400_- FIG00010844 54 9 54 Flavodoxin Flavodoxin 1 T2D_unique_276313_1_400_- FIG00000866 8 3 10 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9) Menaquinone and Phylloquinone Biosynthesis 2.x T2D_unique_276318_266_400_+ FIG00002914 5 2 6 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_276335_95_400_- FIG00000065 66 11 67 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_276344_1_400_- FIG00009564 97 15 97 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_276353_1_400_- FIG00020576 29 8 42 Predicted nucleoside ABC transporter, ATP-binding component Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_276358_1_400_- FIG00018561 70 11 72 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_276364_1_400_+ FIG00001076 27 8 41 Pyruvate,phosphate dikinase (EC 2.7.9.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_276366_1_400_+ FIG00000578 29 5 30 DNA topoisomerase III (EC 5.99.1.2) DNA processing cluster 1.1 T2D_unique_276368_1_400_- FIG00059211 5 3 7 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_276379_1_400_+ FIG00028476 13 5 15 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_276385_1_400_+ FIG00000372 15 6 16 ATP-dependent DNA helicase UvrD/PcrA CBSS-393121.3.peg.1913 1 T2D_unique_276393_1_400_+ FIG00001824 14 4 15 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_276404_1_400_+ FIG00059211 15 4 17 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_276423_1_400_- FIG00000080 85 14 86 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_276441_1_400_- FIG00001758 23 4 24 Late competence protein ComGB, access of DNA to ComEA Gram Positive Competence 3100 T2D_unique_276450_1_400_- FIG00093180 102 16 103 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_276495_1_400_+ FIG00000011 19 5 20 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_276498_166_400_+ FIG00000377 27 5 28 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_276512_1_400_- FIG00000680 26 5 27 DinG family ATP-dependent helicase YoaA DNA repair, bacterial DinG and relatives 1.0101 T2D_unique_276525_1_400_+ FIG00000011 46 11 48 Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) Peptidoglycan Biosynthesis 1.9 T2D_unique_276534_1_400_+ FIG00000721 4 2 5 Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) Formate hydrogenase 3.1?? T2D_unique_276547_1_234_+ FIG00138468 14 3 16 Cobyrinic acid A,C-diamide synthase Cobalamin synthesis 2 T2D_unique_276553_201_344_+ FIG00001067 3 2 4 Rubrerythrin Oxidative stress 1.2 T2D_unique_276573_1_400_+ FIG00137450 15 4 16 hypothetical protein PA3071 CBSS-345072.3.peg.1318 1 T2D_unique_276582_1_400_+ FIG00020185 13 4 14 Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_276587_1_400_+ FIG00003251 55 11 56 Uracil permease De Novo Pyrimidine Synthesis 1 T2D_unique_276592_1_350_+ FIG01955782 29 6 30 Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.-) Teichuronic acid biosynthesis 9 T2D_unique_276603_150_400_+ FIG00010508 48 8 48 Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_276626_59_400_- FIG00000116 35 7 36 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) tRNA aminoacylation, Phe 1.00 T2D_unique_276635_1_400_- FIG00132839 29 5 30 Glutamine synthetase type III, GlnN (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_276643_1_400_- FIG00000156 9 3 10 DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_276657_94_400_+ FIG00019251 14 4 15 DNA primase (EC 2.7.7.-) DNA-replication 4 T2D_unique_276658_1_400_+ FIG00000069 28 6 28 Prolyl-tRNA synthetase (EC 6.1.1.15) Proline, 4-hydroxyproline uptake and utilization 8 T2D_unique_276664_1_400_- FIG00002541 51 11 53 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_276667_75_400_+ FIG00000459 9 4 10 Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_276668_112_400_+ FIG00008708 7 3 10 NADH dehydrogenase (EC 1.6.99.3) Respiratory dehydrogenases 1 1.129 T2D_unique_276671_1_400_+ FIG00000147 44 11 45 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_276682_1_400_+ FIG00009156 13 4 15 Substrate-specific component RibU of riboflavin ECF transporter ECF class transporters 345678 T2D_unique_276695_1_400_- FIG00000242 28 6 37 DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6) RNA polymerase bacterial 1.000 T2D_unique_276744_1_400_- FIG00006940 43 9 45 Sugar phosphate isomerases/epimerases family protein YcjR Maltose and Maltodextrin Utilization 1.x T2D_unique_276761_1_400_+ FIG00000402 106 16 106 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_276768_1_341_+ FIG00029758 97 13 97 N-carbamoyl-L-amino acid hydrolase (EC 3.5.1.87) Hydantoin metabolism 4 T2D_unique_276783_156_400_+ FIG00139238 11 4 13 Galactoside O-acetyltransferase (EC 2.3.1.18) Lactose utilization 1.00 T2D_unique_276803_1_140_- FIG00004763 30 5 30 Alpha-amylase (EC 3.2.1.1) Maltose and Maltodextrin Utilization 1.x T2D_unique_276844_1_400_+ FIG00000191 30 7 32 Translation elongation factor Ts Translation elongation factors bacterial 1.1 T2D_unique_276849_1_400_+ FIG00001518 8 3 10 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Purine Utilization 1 T2D_unique_276889_1_400_- FIG00001997 8 5 10 Methionine gamma-lyase (EC 4.4.1.11) Methionine Degradation 3 T2D_unique_276894_1_400_- FIG00001635 25 6 26 Translation elongation factor G-related protein Translation elongation factors bacterial 1.1 T2D_unique_276908_200_400_- FIG00130344 37 7 38 Citrate synthase (si) (EC 2.3.3.1) Serine-glyoxylate cycle 1 T2D_unique_276920_1_192_+ FIG00001253 4 2 5 G:T/U mismatch-specific uracil/thymine DNA-glycosylase Uracil-DNA glycosylase 1 T2D_unique_276926_1_400_- FIG00000695 9 3 10 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) Coenzyme A Biosynthesis A.191 T2D_unique_276929_1_400_- FIG00000076 6 3 8 Triosephosphate isomerase (EC 5.3.1.1) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_276944_1_381_+ FIG00003751 4 2 6 Chaperonin (heat shock protein 33) Streptococcus pyogenes recombinatorial zone 8 T2D_unique_276977_1_399_+ FIG00000241 25 8 26 ATP-dependent Clp protease ATP-binding subunit ClpX Proteasome bacterial 1 T2D_unique_276990_92_400_- FIG00000176 32 7 34 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_276995_1_400_+ FIG00083946 11 2 12 Phosphate transport system permease protein PstA (TC 3.A.1.7.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_276998_4_400_- FIG00042267 77 13 77 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) Purine conversions 4.1118100 T2D_unique_277005_1_400_- FIG00001822 60 12 61 Pantothenate:Na+ symporter (TC 2.A.21.1.1) Coenzyme A Biosynthesis A.191 T2D_unique_277008_1_400_- FIG00139150 83 13 85 Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit B p-Aminobenzoyl-Glutamate Utilization 1 T2D_unique_277014_1_400_- FIG00047509 67 14 68 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_277017_1_400_+ FIG00000263 53 10 56 LSU ribosomal protein L4p (L1e) Ribosome LSU bacterial 9 T2D_unique_277018_1_400_+ FIG01260980 34 8 36 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_277024_1_287_- FIG00000402 58 9 59 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_277031_1_387_+ FIG00001712 6 2 8 Transcription accessory protein (S1 RNA-binding domain) CBSS-243265.1.peg.198 1 T2D_unique_277045_117_400_- FIG00000560 25 6 26 Peptide chain release factor 3 Translation termination factors bacterial 1.13 T2D_unique_277081_1_399_- FIG00000402 34 8 37 Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps Multidrug Resistance Efflux Pumps 1.12 T2D_unique_277097_93_399_+ FIG00001020 81 12 81 Pyridoxal kinase (EC 2.7.1.35) Pyridoxin (Vitamin B6) Biosynthesis 2.0 T2D_unique_277105_1_399_- FIG00000997 63 12 64 Protein RtcB RNA 3'-terminal phosphate cyclase 2 T2D_unique_277106_1_399_- FIG00001548 8 2 9 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_277117_1_144_+ FIG00007395 34 5 34 Cation efflux system protein CusF precursor Cobalt-zinc-cadmium resistance 1.26 T2D_unique_277168_1_399_- FIG00009564 106 15 106 Late competence protein ComEC, DNA transport Gram Positive Competence 3100 T2D_unique_277188_1_399_- FIG00011537 95 15 96 Phosphoesterase, DHH family protein CBSS-262719.3.peg.410 1 T2D_unique_277190_1_399_- FIG00000370 27 8 30 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_277199_1_399_+ FIG00000147 33 6 34 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_277209_1_344_+ FIG00000824 13 4 14 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Cobalamin synthesis 2 T2D_unique_277216_160_399_+ FIG00120441 61 9 61 CRISPR-associated protein, Csn1 family CRISPRs 1 T2D_unique_277218_1_399_+ FIG00002300 9 4 11 Ribulokinase (EC 2.7.1.16) L-Arabinose utilization 1 T2D_unique_277224_1_399_+ FIG01304818 35 7 36 GTP-binding protein Era CBSS-176299.4.peg.1292 3 T2D_unique_277234_1_399_- FIG00001469 21 5 23 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_277253_1_399_+ FIG00000329 26 6 29 S-adenosylmethionine synthetase (EC 2.5.1.6) Methionine Degradation 3 T2D_unique_277254_27_399_+ FIG00000163 18 4 19 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158) Peptidoglycan Biosynthesis 1.9 T2D_unique_277281_1_399_- FIG00060294 99 15 99 ABC transport system, permease component YbhS ATP-dependent efflux pump transporter Ybh 1 T2D_unique_277302_1_399_- FIG00000370 31 6 32 Fructose-bisphosphate aldolase class II (EC 4.1.2.13) Glycolysis and Gluconeogenesis 1.1181 T2D_unique_277309_1_399_+ FIG00000001 7 6 19 Cysteine desulfurase (EC 2.8.1.7) Alanine biosynthesis A.123 T2D_unique_277329_1_399_- FIG00028461 3 2 4 4-alpha-glucanotransferase (amylomaltase) (EC 2.4.1.25) Maltose and Maltodextrin Utilization 1.x T2D_unique_277340_56_399_- FIG00009782 50 9 52 Putative dihydroxyacetone kinase (EC 2.7.1.29), dihydroxyacetone binding subunit Dihydroxyacetone kinases 3 T2D_unique_277357_1_399_- FIG01304601 36 11 37 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_277367_1_399_+ FIG00044622 22 4 24 Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Ribonucleotide reduction 1 T2D_unique_277391_1_399_+ FIG00000080 39 9 40 DNA gyrase subunit A (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_277397_190_399_+ FIG00001616 18 5 19 Isopentenyl-diphosphate delta-isomerase (EC 5.3.3.2) Isoprenoid Biosynthesis 2.x T2D_unique_277412_1_399_+ FIG00001882 25 10 29 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_277414_1_399_+ FIG01260980 3 2 5 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_277428_62_399_- FIG00000176 56 10 57 CTP synthase (EC 6.3.4.2) EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_277443_1_399_+ FIG00031723 14 4 16 Cyclic beta-1,2-glucan synthase (EC 2.4.1.-) Synthesis of osmoregulated periplasmic glucans 1.x T2D_unique_277447_185_399_- FIG00561498 11 5 12 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_277519_1_399_- FIG00000985 96 14 97 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-) Lipoprotein Biosynthesis 1 T2D_unique_277522_58_399_- FIG01304636 9 4 11 NADH-dependent butanol dehydrogenase A (EC 1.1.1.-) Butanol Biosynthesis 3 T2D_unique_277533_1_399_+ FIG00037273 18 3 20 SSU ribosomal protein S2p (SAe) CBSS-312309.3.peg.1965 1 T2D_unique_277546_1_399_- FIG00022140 24 5 26 Peptidase, M23/M37 family CBSS-393121.3.peg.2760 1 T2D_unique_277553_1_340_- FIG00493440 31 5 32 Exodeoxyribonuclease V gamma chain (EC 3.1.11.5) DNA repair, bacterial RecBCD pathway 3 T2D_unique_277559_1_399_+ FIG00038920 21 4 23 Alpha-L-fucosidase (EC 3.2.1.51) L-fucose utilization 1 T2D_unique_277574_1_177_+ FIG00084255 24 5 25 Stage III sporulation protein AC Sporulation Cluster III A 1.x T2D_unique_277589_1_399_+ FIG00024930 36 8 37 1,4-alpha-glucan (glycogen) branching enzyme, GH-13-type (EC 2.4.1.18) Glycogen metabolism 3 T2D_unique_277598_195_399_+ FIG00005237 32 6 32 GTP pyrophosphokinase (EC 2.7.6.5) CBSS-222523.1.peg.1311 1 T2D_unique_277611_1_399_+ FIG00010454 14 4 15 Tricarboxylate transport membrane protein TctA CBSS-49338.1.peg.459 1 T2D_unique_277627_1_399_+ FIG00000194 103 15 103 tmRNA-binding protein SmpB Translation termination factors bacterial 1.13 T2D_unique_277641_1_331_+ FIG00138004 20 5 21 Sucrose phosphorylase (EC 2.4.1.7) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_277651_1_399_+ FIG00018328 18 5 25 Glycosyl transferase, group 1 CBSS-258594.1.peg.3339 1 T2D_unique_277654_1_399_- FIG00000147 23 7 24 Excinuclease ABC subunit A DNA repair, UvrABC system 1 T2D_unique_277672_1_399_+ FIG00028203 9 5 11 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_277680_1_399_- FIG01239241 62 11 63 oxidoreductase of aldo/keto reductase family, subgroup 1 D-gluconate and ketogluconates metabolism 1.3 T2D_unique_277682_1_399_- FIG00561498 67 11 67 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_277705_1_399_+ FIG00034293 51 8 52 Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) CBSS-393121.3.peg.2760 1 T2D_unique_277725_258_399_+ FIG00000177 7 2 8 Translation elongation factor P Translation elongation factors bacterial 1.1 T2D_unique_277726_259_399_+ FIG00010262 31 5 31 Allophanate hydrolase 2 subunit 2 (EC 3.5.1.54) EC699-706 1 T2D_unique_277730_1_288_- FIG00009149 22 7 24 Butyryl-CoA dehydrogenase (EC 1.3.99.2) Acetyl-CoA fermentation to Butyrate A T2D_unique_277747_1_399_- FIG00000126 27 6 28 Ribonuclease HII (EC 3.1.26.4) Ribonuclease H 1.010 T2D_unique_277755_1_302_+ FIG00012267 78 12 78 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_277757_1_399_- FIG00000101 15 4 18 Threonyl-tRNA synthetase (EC 6.1.1.3) tRNA aminoacylation, Thr 1.00 T2D_unique_277792_1_251_- FIG00000038 8 3 9 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_277797_1_399_+ FIG00047414 11 5 12 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I Stringent Response, (p)ppGpp metabolism 1 T2D_unique_277825_1_399_- FIG00000392 62 11 63 Transcription termination factor Rho Transcription factors bacterial 1 T2D_unique_277828_1_399_+ FIG00022996 16 6 17 Aconitate hydratase (EC 4.2.1.3) Serine-glyoxylate cycle 1 T2D_unique_277832_1_292_+ FIG00007694 6 2 8 Butyrate kinase (EC 2.7.2.7) Acetyl-CoA fermentation to Butyrate A T2D_unique_277844_1_399_+ FIG00009194 36 8 37 Alpha-mannosidase (EC 3.2.1.24) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_277849_177_399_- FIG00022031 20 4 21 L-fucose mutarotase L-fucose utilization 1 T2D_unique_277850_1_399_+ FIG00000245 9 2 10 Glucose-6-phosphate isomerase (EC 5.3.1.9) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_unique_277861_1_399_- FIG00000038 100 15 100 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) Sialic Acid Metabolism 1.x T2D_unique_277863_1_399_+ FIG00004502 82 14 83 5'-nucleotidase YjjG (EC 3.1.3.5) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_277868_1_177_+ FIG00000377 46 7 46 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_277869_1_399_+ FIG00001469 109 15 109 Beta-glucosidase (EC 3.2.1.21) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_277897_72_399_- FIG01298199 85 13 85 Transmembrane component STY3231 of energizing module of queuosine-regulated ECF transporter ECF class transporters 345678 T2D_unique_277927_1_399_+ FIG00000504 13 3 15 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_277931_1_399_+ FIG00042616 23 6 25 Dihydroxyacetone kinase family protein A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_277933_1_190_+ FIG00002022 17 4 18 Nucleotide excision repair protein, with UvrB/UvrC motif Proteolysis in bacteria, ATP-dependent 3 T2D_unique_277934_14_399_- FIG00016514 10 2 11 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_277940_1_399_- FIG00000441 10 2 12 Chromosomal replication initiator protein DnaA Cell Division Subsystem including YidCD 1 T2D_unique_277942_229_399_+ FIG00002034 12 3 13 CRISPR-associated helicase Cas3 CRISPRs 1 T2D_unique_277946_1_399_+ FIG00000365 26 7 29 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) Proline Synthesis 1 T2D_unique_277947_1_399_+ FIG00079521 74 13 74 TRAP dicarboxylate transporter, DctM subunit, unknown substrate 8 CBSS-49338.1.peg.459 1 T2D_unique_277985_1_399_+ FIG00040843 22 6 24 Hexuronate transporter Alginate metabolism 4.xx T2D_unique_277991_110_399_+ FIG00004528 39 8 39 Di-/tripeptide transporter Proton-dependent Peptide Transporters 1 T2D_unique_278017_139_399_+ FIG00000404 10 4 11 DNA polymerase I (EC 2.7.7.7) DNA Repair Base Excision 4 T2D_unique_278022_1_262_+ FIG00001824 17 7 18 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_278060_63_399_- FIG00554193 30 6 31 Tripeptide aminopeptidase (EC 3.4.11.4) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_r2_2558_945_1133_+ FIG00016566 11 3 12 Arylsulfatase (EC 3.1.6.1) Galactosylceramide and Sulfatide metabolism 7 T2D_r2_6436_2905_3039_+ FIG00003955 17 3 17 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC Cell Division Cluster 1.x T2D_r2_8883_1_187_+ FIG00133325 41 7 41 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_r2_14229_1_547_- FIG00133583 100 18 101 Predicted cobalt transporter in sulfate-reducing delta-proteobacteria Transport of Nickel and Cobalt 7 T2D_r2_15383_905_1180_- FIG00016836 24 5 25 Transcription termination protein NusB Transcription factors bacterial 1 T2D_r2_18309_1_126_+ FIG00031250 6 2 7 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_r2_24582_1017_1485_+ FIG00002968 34 7 36 Undecaprenyl-phosphate galactosephosphotransferase (EC 2.7.8.6) CBSS-258594.1.peg.3339 1 T2D_r2_25370_1154_1294_+ FIG00001307 27 5 27 PTS system, galactitol-specific IIC component (EC 2.7.1.69) D-Tagatose and Galactitol Utilization 1.x T2D_r2_25471_785_1087_+ FIG00022631 49 8 51 Acetyl-coenzyme A synthetase (EC 6.2.1.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_25995_1_205_- FIG00023463 48 7 48 heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta Anaerobic respiratory reductases 3 T2D_r2_32679_985_1256_- FIG00023463 66 10 69 heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta Anaerobic respiratory reductases 3 T2D_r2_33819_1076_1231_+ FIG00132717 38 6 38 ATP-dependent protease La (EC 3.4.21.53) Type II Proteasome bacterial 1 T2D_r2_35777_795_1064_+ FIG00004730 44 7 45 YbbM seven transmembrane helix protein Broadly distributed proteins not in subsystems 1 T2D_r2_38193_1_132_- FIG00000260 27 4 27 rRNA small subunit methyltransferase I CBSS-160492.1.peg.550 1 T2D_r2_39881_1_300_- FIG00036406 67 10 68 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_r2_40645_1_276_- FIG00001059 66 11 67 TolA protein Ton and Tol transport systems 2 T2D_r2_43309_1_412_- FIG00001385 93 14 94 N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) Zinc regulated enzymes 1 T2D_r2_43315_849_1010_+ FIG00000741 37 5 37 2-amino-3-ketobutyrate coenzyme A ligase (EC 2.3.1.29) Glycine and Serine Utilization 1.12 T2D_r2_49191_526_978_+ FIG00138308 108 17 109 Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG Lactate utilization 3 T2D_r2_51980_1_204_- FIG00000641 39 7 39 Cob(I)alamin adenosyltransferase (EC 2.5.1.17) Cobalamin synthesis 2 T2D_r2_53001_413_932_+ FIG00017431 130 19 130 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_r2_53405_357_914_- FIG00017431 79 14 83 Serine phosphatase RsbU, regulator of sigma subunit SigmaB stress responce regulation 4.?x T2D_r2_53904_582_921_- FIG00095599 85 12 87 formate dehydrogenase formation protein FdhE Formate hydrogenase 3.1?? T2D_r2_56212_1_168_+ FIG00000539 28 5 29 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) Ammonia assimilation 1 T2D_r2_59351_1_139_- FIG00000303 36 5 36 Histidinol dehydrogenase (EC 1.1.1.23) Histidine Biosynthesis 1 T2D_r2_63337_1_143_- FIG00047509 27 5 27 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_r2_65473_596_810_+ FIG00006463 9 3 10 TRAP-type C4-dicarboxylate transport system, large permease component CBSS-49338.1.peg.459 1 T2D_r2_65980_1_200_+ FIG00136922 51 7 51 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_75091_405_599_+ FIG00060542 5 2 6 Heme biosynthesis protein related to NirD and NirG Heme biosynthesis orphans 3 T2D_r2_81885_54_206_- FIG00229393 30 5 30 Predicted regulator of methionine metabolism, ArsR family Methionine Biosynthesis 8 T2D_r2_86592_1_257_+ FIG00009450 32 6 34 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_r2_87489_98_659_+ FIG01278337 105 16 105 Cytochrome c family protein Copper homeostasis 12 T2D_r2_89773_1_551_- FIG00474174 27 7 29 Tungsten-containing aldehyde:ferredoxin oxidoreductase (EC 1.2.7.5) ABC transporter tungstate (TC 3.A.1.6.2) 1 T2D_r2_92353_1_562_+ FIG00000789 35 8 38 Phosphoenolpyruvate synthase (EC 2.7.9.2) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_95059_1_620_+ FIG00136922 173 25 173 Succinate dehydrogenase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_95591_1_618_+ FIG00010536 154 24 154 HemX protein, negative effector of steady-state concentration of glutamyl-tRNA reductase CBSS-196164.1.peg.461 2 T2D_r2_96416_1_149_+ FIG00000897 23 4 23 Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4) Ribonucleotide reduction 1 T2D_r2_98069_1_606_+ FIG00000789 7 3 9 Phosphoenolpyruvate synthase (EC 2.7.9.2) Glycolysis and Gluconeogenesis, including Archaeal enzymes 1999 T2D_r2_102995_1_412_- FIG00033697 104 16 104 Nitric-oxide reductase (EC 1.7.99.7), quinol-dependent Nitrosative stress 4 T2D_r2_105085_429_576_+ FIG00000103 35 5 35 Heat shock protein GrpE Protein chaperones 2.0 T2D_r2_108160_362_564_- FIG01260980 3 2 4 TonB-dependent receptor Ton and Tol transport systems 2 T2D_r2_112208_1_323_- FIG00004568 54 8 55 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Alkanesulfonate assimilation 9.? T2D_r2_112377_1_549_- FIG00095599 141 21 141 formate dehydrogenase formation protein FdhE Formate hydrogenase 3.1?? T2D_r2_114086_337_543_+ FIG00018699 49 7 49 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_114918_283_540_- FIG00561003 66 10 66 putative glycosyltransferase protein CBSS-258594.1.peg.3339 1 T2D_r2_116390_1_535_- FIG00000287 128 19 129 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_r2_117650_306_531_- FIG00003573 42 7 43 FIG003573: hypothetical protein CBSS-262719.3.peg.410 1 T2D_r2_120909_1_258_- FIG00023463 63 10 63 heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta Anaerobic respiratory reductases 3 T2D_r2_121585_1_519_+ FIG00067681 124 20 125 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_122664_1_188_- FIG00012347 43 7 43 Heterodisulfide reductase, cytochrome reductase subunit Anaerobic respiratory reductases 3 T2D_r2_126224_1_127_+ FIG00006092 11 2 12 RNA polymerase sigma-54 factor RpoN Transcription initiation, bacterial sigma factors 1 T2D_r2_126838_368_504_+ FIG00022899 20 4 21 Threonine dehydratase (EC 4.3.1.19) Branched-Chain Amino Acid Biosynthesis 8 T2D_r2_133773_314_486_+ FIG00080955 23 4 23 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_137797_154_475_- FIG00136193 58 11 58 Dihydrolipoamide dehydrogenase (EC 1.8.1.4) Dehydrogenase complexes 1.2100 T2D_r2_138205_1_474_- FIG00080955 108 17 108 Helicase PriA essential for oriC/DnaA-independent DNA replication DNA-replication 4 T2D_r2_140723_1_227_- FIG00016768 56 8 56 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_r2_141028_229_468_+ FIG00043470 63 9 63 Acetyl-CoA synthetase (ADP-forming) alpha chain (EC 6.2.1.13) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_r2_142019_1_273_- FIG00009770 69 10 69 Transcriptional regulator BkdR of isoleucine and valine catabolism operon Dehydrogenase complexes 1.2100 T2D_r2_143726_306_461_- FIG00002129 39 6 39 Threonine kinase in B12 biosynthesis Cobalamin synthesis 2 T2D_r2_144687_185_459_- FIG00001059 73 11 73 TolA protein Ton and Tol transport systems 2 T2D_r2_147075_1_454_+ FIG00018699 74 14 75 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_r2_154039_210_438_+ FIG00001401 4 3 6 Gluconate dehydratase (EC 4.2.1.39) D-gluconate and ketogluconates metabolism 1.3 T2D_r2_156675_281_432_- FIG00000997 38 6 38 Protein RtcB RNA 3'-terminal phosphate cyclase 2 T2D_r2_158576_1_135_+ FIG00007339 27 5 27 transcriptional regulator, Crp/Fnr family Oxidative stress 1.2 T2D_r2_158986_1_134_- FIG00207095 23 5 23 Membrane fusion protein of RND family multidrug efflux pump Multidrug Resistance Efflux Pumps 1.12 T2D_r2_159670_120_426_+ FIG00067681 64 11 65 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_r2_160051_124_425_- FIG00055715 67 11 67 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_r2_164002_177_416_+ FIG00340411 3 2 4 Putative tricarboxylic transport TctC CBSS-49338.1.peg.459 1 T2D_r2_165084_256_414_- FIG00543846 38 6 38 Dolichol-phosphate mannosyltransferase (EC 2.4.1.83) in lipid-linked oligosaccharide synthesis cluster Lipid-linked oligosaccharide synthesis related cluster 1.x T2D_r2_165926_281_412_+ FIG00000298 25 5 25 GTP-binding protein EngB Universal GTPases 2 T2D_r2_166061_2_412_- FIG00000333 6 3 7 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_r2_169173_258_406_- FIG00014907 25 5 25 Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2) ABC transporter dipeptide (TC 3.A.1.5.2) 1 T2D_r2_169718_1_170_+ FIG00048014 44 6 44 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_r2_170361_1_294_+ FIG00229393 7 4 9 Predicted regulator of methionine metabolism, ArsR family Methionine Biosynthesis 8 T2D_r2_170500_1_403_- FIG00029916 100 15 101 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_r2_171032_1_402_- FIG00002273 54 14 55 N-methylhydantoinase (ATP-hydrolyzing) (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_r2_171848_1_401_- FIG00846773 87 14 87 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_r4_24927_262_514_+ FIG00020370 63 10 63 Phage tape measure Phage tail proteins 2 4 T2D_unique_94_1955_2101_- FIG00028203 27 4 27 DNA gyrase subunit B (EC 5.99.1.3) Cell Division Subsystem including YidCD 1 T2D_unique_116_42779_42943_+ FIG00012267 34 5 35 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_371_11805_11942_- FIG00000812 29 5 29 L-lactate dehydrogenase (EC 1.1.1.27) Fermentations: Mixed acid 1 T2D_unique_1900_7610_7873_+ FIG00001232 3 2 5 AMP nucleosidase (EC 3.2.2.4) Purine conversions 4.1118100 T2D_unique_1962_9355_9516_+ FIG00041038 35 5 36 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_2077_8986_9161_+ FIG00039112 44 6 44 Putative uncharacterized protein in cluster with two glycosyl transferases Exopolysaccharide Biosynthesis 1.0 T2D_unique_4315_1_208_- FIG00001863 40 6 42 YlxP-like protein NusA-TFII Cluster 4 T2D_unique_4513_3111_3422_+ FIG00021347 9 4 11 Death on curing protein, Doc toxin Phd-Doc, YdcE-YdcD toxin-antitoxin (programmed cell death) systems 1.2x T2D_unique_9689_3020_3228_+ FIG00687285 50 8 50 Outer membrane protein/protective antigen OMA87 CBSS-316057.3.peg.659 1 T2D_unique_12104_1_247_- FIG00000047 20 3 21 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_16174_1_127_+ FIG00028476 27 5 27 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_20660_1_439_+ FIG00011468 60 10 62 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_21060_1858_2000_+ FIG00137824 32 5 33 Iron compound ABC uptake transporter substrate-binding protein PiuA Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_21505_1761_1976_- FIG00000269 41 6 42 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_24300_1_167_- FIG00846773 43 6 43 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_26449_902_1081_+ FIG00133325 20 3 21 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Proline Synthesis 1 T2D_unique_30397_887_1036_+ FIG00019881 11 2 12 Cell surface protein Shp, transfers heme from hemoglobin to apo-SiaA/HtsA Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_31167_1449_1583_+ FIG00003284 24 4 24 Colicin I receptor precursor Ton and Tol transport systems 2 T2D_unique_31908_1039_1269_+ FIG00001824 64 9 64 Teichoic acid export ATP-binding protein TagH (EC 3.6.3.40) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_32190_1_130_- FIG00003520 11 2 12 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_33278_958_1521_- FIG00011468 105 18 108 Phage tail length tape-measure protein Phage tail proteins 2 4 T2D_unique_33575_1296_1513_- FIG00006336 56 8 56 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_34187_1_250_+ FIG00002130 46 7 46 Glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein (TC 3.A.1.1.3) Glycerol and Glycerol-3-phosphate Uptake and Utilization 2.13 T2D_unique_34202_1315_1497_+ FIG00104848 44 7 44 Phosphate transport system regulatory protein PhoU High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_35407_1291_1467_+ FIG00000287 24 4 25 Cell division protein FtsK Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_44577_1_181_- FIG00000269 32 5 32 Transcription antitermination protein NusG Transcription factors bacterial 1 T2D_unique_44756_1_134_+ FIG00000414 18 4 18 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) DNA processing cluster 1.1 T2D_unique_48230_1075_1217_+ FIG00050243 30 5 30 Alanyl-tRNA synthetase family protein tRNA aminoacylation, Ala 1.01 T2D_unique_49270_1_177_+ FIG00053889 41 7 41 Pyruvate dehydrogenase E1 component alpha subunit (EC 1.2.4.1) Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_49887_1034_1192_+ FIG00001904 41 6 41 Outer surface protein of unknown function, cellobiose operon Beta-Glucoside Metabolism 2.bc T2D_unique_51259_994_1173_- FIG00001294 27 5 28 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_unique_51788_1029_1165_+ FIG00005728 23 4 24 Methyl-accepting chemotaxis protein I (serine chemoreceptor protein) Bacterial Chemotaxis 9 T2D_unique_53420_692_1126_+ FIG01304601 76 12 77 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_53759_993_1139_- FIG00138308 30 5 30 Predicted L-lactate dehydrogenase, hypothetical protein subunit YkgG Lactate utilization 3 T2D_unique_54055_1005_1135_+ FIG01260980 28 5 28 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_54293_778_1014_+ FIG00037500 56 8 56 Phage minor capsid protein Phage head and packaging 1 T2D_unique_58986_703_888_+ FIG00064154 4 2 5 ParE toxin protein Toxin-antitoxin systems (other than RelBE and MazEF) 1 T2D_unique_62195_1_145_+ FIG00000681 38 5 38 Beta-lactamase class C and other penicillin binding proteins Beta-lactamase 1 T2D_unique_62638_431_571_- FIG00000756 36 5 36 Ribosomal-protein-S5p-alanine acetyltransferase Ribosomal protein S5p acylation 1 T2D_unique_62693_1_145_+ FIG00026918 19 3 20 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_62977_789_968_- FIG00008778 48 7 48 Maltose operon transcriptional repressor MalR, LacI family Maltose and Maltodextrin Utilization 1.x T2D_unique_64312_581_1020_- FIG00020897 95 14 96 Acetylornithine deacetylase (EC 3.5.1.16) Arginine Biosynthesis extended 1.0 T2D_unique_65271_878_1010_- FIG00016663 8 2 9 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_66296_553_1001_- FIG00005710 124 18 125 Beta-lactamase class A Beta-lactamase 1 T2D_unique_67482_1_177_+ FIG00000838 44 7 44 Trk system potassium uptake protein TrkA Bacterial RNA-metabolizing Zn-dependent hydrolases 1 T2D_unique_68552_1_306_- FIG00025759 5 2 6 Orotate phosphoribosyltransferase (EC 2.4.2.10) De Novo Pyrimidine Synthesis 1 T2D_unique_69912_1_478_- FIG00001450 123 18 123 Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34) Isoprenoid Biosynthesis 2.x T2D_unique_70090_714_968_+ FIG00013339 58 9 58 Protein of unknown function DUF208 tRNA aminoacylation, Glu and Gln 3.01 T2D_unique_70934_1_302_- FIG00030191 48 7 49 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_72453_1_260_+ FIG00018396 46 8 48 Thioredoxin reductase (EC 1.8.1.9) Thioredoxin-disulfide reductase 2 T2D_unique_78374_636_904_- FIG00051957 70 10 70 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_80234_4_246_- FIG00138182 8 3 9 Beta-mannosidase (EC 3.2.1.25) Mannose Metabolism 2.0 T2D_unique_82895_211_378_- FIG00023946 46 6 46 CRISPR-associated protein Cas1 CRISPRs 1 T2D_unique_86444_1_147_- FIG00051957 32 5 32 Substrate-specific component FolT of folate ECF transporter ECF class transporters 345678 T2D_unique_89540_1_161_+ FIG00001408 9 2 10 Rrf2 family transcriptional regulator Rrf2 family transcriptional regulators 4 T2D_unique_92771_542_697_- FIG00000411 7 2 8 Biotin carboxyl carrier protein of acetyl-CoA carboxylase EC 6.3.4.- Ligases that form carbon-nitrogen bonds 1 T2D_unique_93216_143_418_- FIG00003587 27 4 28 Radical SAM domain heme biosynthesis protein Heme biosynthesis orphans 3 T2D_unique_94766_1_212_+ FIG00015833 55 8 55 Oligosaccharide repeat unit polymerase Wzy Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_94910_34_174_- FIG00002311 9 3 10 Septation ring formation regulator EzrA CBSS-393130.3.peg.794 2 T2D_unique_94976_660_802_+ FIG00018536 6 2 7 Electron transport complex protein RnfC Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 7 T2D_unique_96038_551_797_- FIG00001882 52 8 52 6-phospho-beta-glucosidase (EC 3.2.1.86) Beta-Glucoside Metabolism 2.bc T2D_unique_97069_412_609_+ FIG00000861 50 7 50 Gluconokinase (EC 2.7.1.12) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_101518_575_770_+ FIG00000504 8 2 9 Polyphosphate kinase (EC 2.7.4.1) High affinity phosphate transporter and control of PHO regulon 1 T2D_unique_104543_209_349_- FIG01260980 9 2 10 TonB-dependent receptor Ton and Tol transport systems 2 T2D_unique_106569_152_397_- FIG00059211 42 8 43 RecD-like DNA helicase YrrC DNA repair, bacterial RecBCD pathway 3 T2D_unique_107503_587_742_- FIG00049336 36 5 36 Foldase protein PrsA precursor (EC 5.2.1.8) Peptidyl-prolyl cis-trans isomerase 1 T2D_unique_107828_433_741_- FIG00002652 80 12 80 CDP-glycerol: N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_110219_1_180_+ FIG00001676 35 5 36 Ferredoxin Soluble cytochromes and functionally related electron carriers 3.4 T2D_unique_110248_358_731_- FIG00000333 99 14 99 Argininosuccinate lyase (EC 4.3.2.1) Arginine Biosynthesis extended 1.0 T2D_unique_111161_1_210_- FIG00004078 22 4 23 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_112441_427_722_- FIG00000747 34 7 35 Beta-lactamase (EC 3.5.2.6) Beta-lactamase 1 T2D_unique_113267_190_435_- FIG00030191 59 9 59 Serine/threonine protein kinase PrkC, regulator of stationary phase A Gram-positive cluster that relates ribosomal protein L28P to a set of uncharacterized proteins 1 T2D_unique_113696_1_315_+ FIG01304601 73 11 73 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_117329_571_702_+ FIG00005172 27 5 27 Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_117620_556_701_+ FIG00093180 13 4 13 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_120613_1_175_- FIG00047509 34 6 34 Methionine ABC transporter substrate-binding protein Methionine Degradation 3 T2D_unique_122912_297_682_- FIG00000315 35 6 36 DNA recombination and repair protein RecO CBSS-176299.4.peg.1292 3 T2D_unique_123573_353_680_+ FIG00018699 67 11 68 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Biotin biosynthesis 1X T2D_unique_125743_362_672_+ FIG00002541 81 12 81 Pyruvate formate-lyase (EC 2.3.1.54) Formate hydrogenase 3.1?? T2D_unique_127693_1_127_+ FIG00134889 23 3 23 Glutamine synthetase type I (EC 6.3.1.2) Peptidoglycan Biosynthesis 1.9 T2D_unique_128623_1_135_- FIG00091606 15 2 15 Methionine synthase activation domain (EC 2.1.1.13) Methionine Biosynthesis 8 T2D_unique_129575_62_196_+ FIG00012267 7 2 9 Sialic acid utilization regulator, RpiR family Sialic Acid Metabolism 1.x T2D_unique_135111_126_434_+ FIG00139343 11 2 12 Iron compound ABC uptake transporter substrate-binding protein Heme, hemin uptake and utilization systems in GramPositives 6 T2D_unique_135508_498_641_+ FIG00007059 12 3 13 Acriflavin resistance protein Multidrug Resistance Efflux Pumps 1.12 T2D_unique_137445_469_635_- FIG00007915 37 5 37 Glyoxalase family protein Serine-glyoxylate cycle 1 T2D_unique_137955_1_147_- 33 5 33 Late competence protein ComGB, access of DNA to ComEA Gram Positive Competence 3100 T2D_unique_140632_1_203_- FIG00475203 25 5 27 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_141097_1_140_- FIG00006336 36 5 36 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_141349_412_624_+ FIG00031250 53 8 53 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) Serine Biosynthesis 2.x T2D_unique_141518_1_623_- FIG00002013 27 7 28 N-methylhydantoinase B (EC 3.5.2.14) Creatine and Creatinine Degradation 4.0 T2D_unique_143110_1_203_- FIG00013534 52 7 52 Substrate-specific component BL0695 of predicted ECF transporter ECF class transporters 345678 T2D_unique_143649_64_231_+ FIG00846773 28 6 28 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_143747_489_617_+ FIG00026918 7 2 8 Chromosome partition protein smc Two cell division clusters relating to chromosome partitioning 1 T2D_unique_145271_1_612_+ FIG00009450 172 24 173 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_145525_483_612_+ FIG00000377 13 3 14 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) Isoprenoid Biosynthesis 2.x T2D_unique_146130_1_297_+ FIG01956146 74 11 74 CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (EC 2.7.8.12) Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_146373_1_252_- FIG00000548 57 9 57 3-polyprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_unique_146616_1_338_- FIG00003788 91 13 91 Glycosyl transferase, group 2 family protein Exopolysaccharide Biosynthesis 1.0 T2D_unique_147697_1_128_+ FIG00055715 20 3 20 Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 1 T2D_unique_149241_264_602_+ FIG00005992 15 3 17 Gamma-glutamyltranspeptidase (EC 2.3.2.2) Glutathione: Biosynthesis and gamma-glutamyl cycle 3 T2D_unique_149510_1_413_- FIG00008812 15 4 17 Formate dehydrogenase -O, gamma subunit (EC 1.2.1.2) Formate hydrogenase 3.1?? T2D_unique_149740_1_137_- FIG00132801 13 3 14 Sensor histidine kinase VanS (EC 2.7.3.-) Resistance to Vancomycin X T2D_unique_149960_1_600_+ FIG00001548 3 2 4 Beta-galactosidase (EC 3.2.1.23) Lactose and Galactose Uptake and Utilization 1.0 T2D_unique_150976_453_597_+ FIG00001088 21 5 22 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_151342_1_352_+ FIG00000494 7 3 8 Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_153613_1_149_+ FIG00016555 24 5 24 O-antigen flippase Wzx Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_156097_1_237_- FIG00000861 60 9 60 Gluconokinase (EC 2.7.1.12) D-gluconate and ketogluconates metabolism 1.3 T2D_unique_158751_438_578_- FIG00005710 30 5 30 Beta-lactamase class A Beta-lactamase 1 T2D_unique_161442_350_572_+ FIG00003201 4 4 6 Fumarate reductase cytochrome b subunit Succinate dehydrogenase 5 T2D_unique_162659_393_569_- FIG00000210 7 2 8 SSU ribosomal protein S1p Cell division-ribosomal stress proteins cluster 1 T2D_unique_170479_1_291_- FIG00087875 23 3 24 Multidrug-efflux transporter, major facilitator superfamily (MFS) (TC 2.A.1) Multidrug Resistance Efflux Pumps 1.12 T2D_unique_170850_1_150_+ FIG00000267 7 3 8 Dephospho-CoA kinase (EC 2.7.1.24) Coenzyme A Biosynthesis A.191 T2D_unique_174034_338_545_- FIG00132673 21 4 22 Glycerol-1-phosphate dehydrogenase [NAD(P)] (EC 1.1.1.261) Glycerolipid and Glycerophospholipid Metabolism in Bacteria 1.x T2D_unique_174949_345_543_+ FIG00000065 31 5 32 Exodeoxyribonuclease III (EC 3.1.11.2) DNA repair, bacterial 3 T2D_unique_175198_1_135_- FIG00018369 27 5 27 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_177068_163_539_+ FIG00009450 98 15 98 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_177274_1_507_- FIG00015833 129 19 129 Oligosaccharide repeat unit polymerase Wzy Capsular Polysaccharides Biosynthesis and Assembly 4.0 T2D_unique_179524_287_534_+ FIG00019508 28 6 30 Phage major tail protein Phage tail proteins 2 4 T2D_unique_183509_1_175_+ FIG00025216 16 3 17 ClpB protein Proteolysis in bacteria, ATP-dependent 3 T2D_unique_184020_353_525_- FIG00614545 26 4 26 Acylphosphate phosphohydrolase (EC 3.6.1.7), putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_185103_345_523_+ FIG00013609 41 6 41 DNA-entry nuclease (Competence-specific nuclease) (EC 3.1.30.-) Gram Positive Competence 3100 T2D_unique_185413_173_522_+ FIG01304601 54 9 55 Exonuclease SbcC DNA repair, bacterial 3 T2D_unique_186191_164_382_- FIG00041038 49 7 49 DNA polymerase III alpha subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_186279_362_521_- FIG00058189 38 5 38 Substrate-specific component PdxU2 of predicted pyridoxin-related ECF transporter ECF class transporters 345678 T2D_unique_186715_1_152_+ FIG00017458 17 3 18 Sensor histidine kinase VncS Streptococcus pneumoniae Vancomycin Tolerance Locus 3 T2D_unique_187957_1_129_+ FIG00016663 33 5 33 TRAP-type C4-dicarboxylate transport system, periplasmic component CBSS-49338.1.peg.459 1 T2D_unique_191246_381_512_- FIG00003394 11 2 11 5'-nucleotidase (EC 3.1.3.5) Purine conversions 4.1118100 T2D_unique_191313_329_512_+ FIG00060517 50 7 50 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_193266_1_130_- FIG00122134 34 5 34 Malolactic regulator Pyruvate metabolism I: anaplerotic reactions, PEP 1 T2D_unique_194359_316_506_- FIG00060517 38 7 38 Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) DNA Repair Base Excision 4 T2D_unique_196843_113_502_- FIG00001547 85 12 86 ATP-dependent nuclease, subunit A ATP-dependent Nuclease 1 T2D_unique_200829_1_495_- FIG00003201 16 3 17 Fumarate reductase cytochrome b subunit Succinate dehydrogenase 5 T2D_unique_201692_245_494_+ FIG00004078 24 4 25 Alpha-1,2-mannosidase Mannose Metabolism 2.0 T2D_unique_202470_1_318_+ FIG00004655 86 12 86 Polysaccharide deacetylase Polysaccharide deacetylases 2.1 T2D_unique_203748_282_491_+ FIG00000582 5 2 7 Homoserine kinase (EC 2.7.1.39) Threonine and Homoserine Biosynthesis 1.1 T2D_unique_209459_238_482_+ FIG00002020 64 9 64 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_210407_75_480_- FIG00008077 110 16 110 Putative pheromone cAM373 precursor lipoprotein CamS Sex pheromones in Enterococcus faecalis and other Firmicutes 1 T2D_unique_211094_217_479_- FIG00134368 63 9 64 Cytosine deaminase (EC 3.5.4.1) Creatine and Creatinine Degradation 4.0 T2D_unique_213897_236_475_- FIG00023369 36 8 37 Chaperone protein DnaK Protein chaperones 2.0 T2D_unique_214016_318_475_- FIG00007256 26 5 26 FIG139598: Potential ribosomal protein CBSS-176279.3.peg.868 1.x T2D_unique_217004_1_165_+ FIG00001011 12 2 13 Beta-glucoside bgl operon antiterminator, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_220195_1_214_- FIG00846773 46 8 46 Permease of the drug/metabolite transporter (DMT) superfamily Cobalt-zinc-cadmium resistance 1.26 T2D_unique_225241_1_459_- FIG00020643 112 17 112 Cell wall surface anchor family protein, FPXTG motif Sortase 1.12 T2D_unique_225303_1_158_+ FIG00074916 21 5 23 Acetolactate synthase, catabolic (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_226027_1_126_+ FIG00004744 24 5 24 Rare lipoprotein A precursor Peptidoglycan Biosynthesis 1.9 T2D_unique_227008_40_342_- FIG00010310 7 3 9 ATP-dependent DNA helicase pcrA (EC 3.6.1.-) CBSS-393121.3.peg.1913 1 T2D_unique_228025_1_402_+ FIG00000584 110 16 110 Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) Housecleaning nucleoside triphosphate pyrophosphatases 1 T2D_unique_228924_155_454_- FIG00000527 88 12 88 Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1) Purine conversions 4.1118100 T2D_unique_229382_1_171_- FIG00001088 22 4 23 Beta-hexosaminidase (EC 3.2.1.52) Chitin and N-acetylglucosamine utilization 2 T2D_unique_232078_285_450_- FIG00000548 6 2 8 3-polyprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.-) Ubiquinone Biosynthesis 2.x T2D_unique_232162_109_237_- FIG00000145 25 4 25 Cell division protein FtsZ (EC 3.4.24.-) Cell Division Cluster 1.x T2D_unique_235357_1_252_+ FIG00002847 13 4 14 HflK protein Hfl operon 1.111 T2D_unique_236700_1_444_- FIG00030585 8 3 10 Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 1 T2D_unique_237738_176_443_+ FIG00003520 9 3 10 Phage tail fiber protein Phage tail fiber proteins 2 T2D_unique_239605_1_177_- FIG00011057 9 2 11 Deoxyribonucleoside regulator DeoR (transcriptional repressor) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_240496_166_440_- FIG00071708 61 9 61 CRISPR-associated protein Csm6 CRISPR-associated cluster 1 T2D_unique_241213_50_439_+ FIG00130339 11 2 12 Cytochrome c heme lyase subunit CcmF Copper homeostasis 12 T2D_unique_243735_255_436_+ FIG00067681 28 5 28 Transcription-repair coupling factor Transcription factors bacterial 1 T2D_unique_244516_1_131_+ FIG00016514 20 4 21 Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) Restriction-Modification System 3.x T2D_unique_244559_282_435_- FIG00059426 36 6 36 Cytoplasmic axial filament protein CafA and Ribonuclease G (EC 3.1.4.-) RNA processing and degradation, bacterial 1 T2D_unique_246139_164_433_+ FIG00022300 48 9 49 UDP-glucose 4-epimerase (EC 5.1.3.2) Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway 2.0 T2D_unique_246149_186_433_- FIG00475203 6 2 8 Endo-1,4-beta-xylanase A precursor (EC 3.2.1.8) Xylose utilization 1 T2D_unique_246165_1_237_- FIG01010650 15 2 15 Transport ATP-binding protein CydD Terminal cytochrome d ubiquinol oxidases 1 T2D_unique_246785_1_168_+ FIG00000423 39 6 39 Dethiobiotin synthetase (EC 6.3.3.3) Biotin biosynthesis 1X T2D_unique_247339_204_431_- FIG00003506 6 2 8 Cytosine/purine/uracil/thiamine/allantoin permease family protein Purine Utilization 1 T2D_unique_248011_1_377_+ FIG00744931 42 9 43 Phage tail assembly Phage tail proteins 2 4 T2D_unique_249934_1_428_+ FIG00003460 10 3 11 Transcriptional regulator, MerR family Cobalt-zinc-cadmium resistance 1.26 T2D_unique_250052_1_163_- FIG00014596 45 6 45 Cobalamin biosynthesis protein CbiG Cobalamin synthesis 2 T2D_unique_251079_1_131_- FIG00000095 29 5 29 Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) Universal GTPases 2 T2D_unique_251179_281_427_+ FIG00001166 17 3 19 Arginine/ornithine antiporter ArcD Polyamine Metabolism 2 T2D_unique_254735_1_344_+ FIG00135469 72 11 73 Aminopeptidase YpdF (MP-, MA-, MS-, AP-, NP- specific) Protein degradation 1 T2D_unique_255466_52_422_- FIG00093180 34 6 36 Choline binding protein A Choline and Betaine Uptake and Betaine Biosynthesis 3.0 T2D_unique_255755_1_422_+ FIG00029916 117 17 117 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) Beta-Glucoside Metabolism 2.bc T2D_unique_257124_1_420_+ FIG00009450 49 8 49 Peptidoglycan N-acetylglucosamine deacetylase (EC 3.5.1.-) Polysaccharide deacetylases 2.1 T2D_unique_258317_1_419_+ FIG00136692 108 16 108 Acetolactate synthase large subunit (EC 2.2.1.6) Acetoin, butanediol metabolism 5 T2D_unique_259123_1_179_- FIG00002974 44 7 44 Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8) Nucleoside triphosphate pyrophosphohydrolase MazG 1.100 T2D_unique_259493_214_418_- FIG00006151 13 2 14 Methionine ABC transporter ATP-binding protein Methionine Degradation 3 T2D_unique_261213_1_416_- FIG00048014 4 3 6 Fumarate reductase flavoprotein subunit (EC 1.3.99.1) Succinate dehydrogenase 5 T2D_unique_264393_23_385_+ FIG00013609 13 3 14 DNA-entry nuclease (Competence-specific nuclease) (EC 3.1.30.-) Gram Positive Competence 3100 T2D_unique_265298_235_411_- FIG00016768 19 4 20 TRAP-type uncharacterized transport system, fused permease component CBSS-49338.1.peg.459 1 T2D_unique_268112_1_408_- FIG00006336 100 15 100 Transcriptional antiterminator of lichenan operon, BglG family Beta-Glucoside Metabolism 2.bc T2D_unique_268644_46_408_- FIG00001294 85 14 85 Adenylate cyclase (EC 4.6.1.1) CBSS-222523.1.peg.1311 1 T2D_unique_269318_1_169_+ FIG00023690 6 2 7 DNA polymerase III chi subunit (EC 2.7.7.7) DNA-replication 4 T2D_unique_270164_1_406_+ FIG00006962 100 16 101 NAD-reducing hydrogenase subunit HoxY (EC 1.12.1.2) Hydrogenases 2 T2D_unique_270273_275_406_+ FIG00028476 11 3 14 Ribokinase (EC 2.7.1.15) Deoxyribose and Deoxynucleoside Catabolism 2.0 T2D_unique_270464_1_406_- FIG00002020 109 15 109 Alpha-galactosidase (EC 3.2.1.22) Fructooligosaccharides(FOS) and Raffinose Utilization 1.0 T2D_unique_271693_1_185_- FIG00561498 40 6 40 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_272261_1_225_- FIG00001093 27 6 28 Electron transfer flavoprotein-ubiquinone oxidoreductase (EC 1.5.5.1) Acetyl-CoA fermentation to Butyrate A T2D_unique_273098_50_403_- FIG01278268 66 11 66 Teichoic acid biosynthesis protein Teichoic and lipoteichoic acids biosynthesis 9.104 T2D_unique_273240_1_403_+ FIG00018369 6 2 8 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_273877_1_403_- FIG00018369 74 12 75 Cell division protein FtsH (EC 3.4.24.-) Cell division-ribosomal stress proteins cluster 1 T2D_unique_274616_22_402_- FIG00000313 3 2 5 Catalase (EC 1.11.1.6) Oxidative stress 1.2 T2D_unique_274818_238_402_+ FIG00561498 38 5 38 D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) Murein Hydrolases 3 T2D_unique_274895_1_158_- FIG00003433 28 5 29 Vancomycin B-type resistance protein VanW Resistance to Vancomycin X T2D_unique_275723_246_401_+ FIG00000990 13 2 14 Recombination inhibitory protein MutS2 DNA repair, bacterial MutL-MutS system 1 T2D_unique_275865_1_160_+ FIG00013366 18 3 19 ADP-heptose--lipooligosaccharide heptosyltransferase II (EC 2.4.1.-) LOS core oligosaccharide biosynthesis 1.x T2D_unique_276692_1_202_+ FIG00089870 15 3 16 Family 13 glycosyl hydrolase, row 724 Sucrose utilization 1.1x T2D_unique_276729_1_400_+ FIG00018865 3 3 4 Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) ABC transporter oligopeptide (TC 3.A.1.5.1) 7